NEW BUILDING IN THE PHD PROGRAM, SYSTEMS BIOLOGY CENTER OF BERLIN PARTNERS & ACTIVITIES AT THE MDC The Berlin Institute for Medical Systems Biology at the Max Delbrück Center for Molecular Medicine Berlin-Buch

For further information contact Grietje Krabbe: [email protected]

Every Wednesday, From 09:30 to 10:30 AM MDC.C Conference Center, Dendrite 2/3 Robert-Rössle-Str. 10, 13125 Berlin COMPUTATIONAL FRIDAY 06 FEBRUARY AT 12 NOON DENDRIT 2-3 A HANDS-ON COURSE ON DATA ANALYSIS Student Seminar Systems Biology in Systems Biology Lectures

Every second Proteins & Proteomics Friday systems Friday 05 SeptemBer at 12 noon dendrit 2-3 biology students Date Speaker Topics LECTURERS / INSTRUCTORS I Berlin present their Djordje 28 October 2015 Matthias Selbach, MDC Shotgun proteomics: an introduction 18-24 OCT 2015 FRIDAY 10 APRIL 12 NOON DENDRIT 2-3 ALTUNA AKALIN work in Vasiljevic Proteome meets genome: dynamics of chromatin 8 Berlin Summer Meeting Germany I Berlin Institute Jeroen Krijgsveldt, EMBL progress. (Selbach lab) 04 November 2015 composition in embryonic stem cells Max Delbrück Center, Berlin Institute for Medical Systems Biology for Medical Systems Biology, 11 November 2015 Oliver Daumke, MDC Structure-function studies in dynamin superfamily proteins For further information contact Jennifer Stewart: [email protected] Bioinformatic Analysis of Proteomic Data using Max Delbrück Center Student Seminar in Stefanie 18 November 2015 Knut Reinert, FU Berlin RICHARD BONNEAU OpenMS and KNIME , Seelk Every Wednesday, from 09:30 to 10:30 AM 25 November 2015 Mathias Dreger, Caprotech Capture Compound Mass Spectrometry:Student A Chemoproteo- Seminar in New York, USA Application Deadline (Tursun lab) mic approach to profile small molecule-protein interactions 30 July 2015 Systems Biology MDC.C Conference Center, MDC Berlin-Buch 02 December 2015 Marcus Bantscheff, Cellzome Drug action in the context of the proteome UWE OHLER Cell-type specific Max Delbrück Center, Robert-Rössle-Str. 10, 13125 Berlin 09 December 2015 Ulrich Stelzl, MPI Molecular Genetics Protein-protein interaction networks protein-protein Systems Biology Berlin Institute for Medical Systems Biology Every interactions in C. A central role NIKOLAUS RAJEWSKY COURSE MODULES second elegans Quantitative Phosphoproteomics to delineate cell 06 January 2016 Jesper Olsen, CPR Copenhagen signaling pathways Every Max Delbrück Center, Friday systems of the histone Berlin Institute for Medical Systems Biology · Introduction to R & Bioconductor biology students 13 January 2016 Phillip Selenko, FMP NMR second · Statistics and Exploratory Data analysis chaperone Lin-53 MARK ROBINSON Lea 20 January 2016 Michiel Vermeulen, University Nijmegen Quantitative interaction proteomics for epigenetics Friday systems · Introduction to Next-gen sequencing present their (Rbbp4/7) in muscle University of Zurich, daempfling Systems Biology · RNA-seq analysis work in 27 January 2016 Erich Wanker, MDC Neuroproteomics biology students Zurich, Switzerland · ChIP-seq analysis (Zinzen lab) homeostasis and present their MODEL ORGANISMS progress. 03 February 2016 Anne-Claude Gavin, EMBL Protein Metabolite Interactions Fabian · Data integration and visualization aging regulation NICHOLAS D. SOCCI Targeted Proteomics / Proteomics of the Ubiquitine work in MEET 10 February 2016 Gunnar Dittmar, MDC Konrath Memorial Sloan Kettering Cancer Center, Proteasome System progress. Christin Lectures (Wolf lab) New York, USA Zasada (Kempa lab) A global analysis Alexander of early nervous Glahs RNA Biology (Zinzen lab) system specification by Dynamical key neural transcription Date & Venue Speaker Topics modelling of DNA Multiparticle cryo-electron microscopy of factors in Drosophila 22-04-15 Axon 2 Christian Spahn Charité From pSIRM to macromolecular machines: the ribosome as an example damage-dependent Spatiotemporal melanogaster Gunter Meister University of RNA binding proteins as modulators of coding and MARS - quantifying 29-04-15 Dendrit 2-3 NF-kappaB activation Regensburg noncoding RNA pathways analysis of http://compgen2015.mdc-berlin.de stem cell and cancer All are most welcome to attend Ribosomal decoding fidelity and tautomerism of nucleic 06-05-15 Axon 2 Eric Westhof IBMC/CNRS Strasbourg acid bases chromatin states TOPIC 2015: Localization of cellular processes metabolism For further information contact Jennifer Stewart: [email protected] 13-05-15 Dendrit 2-3 Niels Gehring Messenger RNA quality control in health and disease in the developing at the MDC Berlin-Buch 20-05-15 Axon 2 Nikolaus Rajewsky MDC/BIMSB Regulatory Drosophila nervous mRNA/endomembrane co-trafficking from yeast to June 4-6 2015, 27-05-15 Dendrit 2-3 Julien Betune Heidelberg University system Steven Altschuler, University of California, San Francisco, USA mammals Gary Bassell, Emory University School of Medicine, Atlanta, USA Regulatory RNAs in the pathogenic Kerstin Bystricky, CNRS Toulouse, France Berlin, Germany Cynthia Sharma University of 03-06-15 Dendrit 2-3 Epsilonproteobacteria, Helicobacter pylori and Würzburg Lionel Christiaen, New York University, New York, USA Campylobacter jejun Xavier Darzacq, University of California, Berkeley, USA Alexander Loewer, Nikolaus Rajewsky, Stephen Small, Robert Zinzen Alternative splicing in four dimensions: how, where, Anne Ephrussi, EMBL Heidelberg, Germany, Location: Umweltforum, Pufendorfstr. 11, 10249 Berlin 10-06-15 Dendrit 2-3 Florian Heyd FUB Luca Giorgetti, Friedrich Miescher Institute, Basel, Switzerland Contact: when and why? Christine Mayr, Memorial Sloan-Kettering Cancer Center, New York, USA Max Delbrück Center for Molecular Medicine Medical systems biology research requires a critical mass of disciplines, Regulation of gene expression by RNA-binding Dierk Niessing, Helmholtz Center Muenchen, Germany 17-06-15 Axon 2 Markus Landthaler MDC/BIMSB Berlin, Germany, phone (+) 49 30 9406 2999 / 3720 proteins Mats Nilsson, Stockholm University, Sweden Ana Pombo, BIMSB at the MDC, Berlin, Germany miRNA repression in mammalian cells: structural LIMITED SPACE AVAILABLE ! 24-06-15 Dendrit 2-3 Witek Filipowicz FMI Basel insights into the mechanism and a role of miRNAs in Antonella Riccio, University College London, UK Joel Richter, University of Massachusetts Medical School, Worcester, USA Abstract submission deadline: March 30, 2015 development and function of mouse retina All are most welcome to attend Silvia Santos, Imperial College London, UK Ralf-Peter Jansen University of Fees (in Euro) 08-07-15 Dendrit 2-3 Cooperation of membrane and mRNA transport Stephen J. Small, New York University, New York, USA For further information contact Jennifer Stewart: [email protected] Tübingen Early registration (until April 15, 2015) 150 Late registration (after April 15, 2015) 250 Transcriptome characterization: past, All are most welcome to attend Students 80 15-07-15 Dendrit 2-3 Wei Chen MDC/BIMSB technologies, experts and collaborations in close proximity, and with easy access present and future For further information contact Jennifer Stewart: [email protected] Campus Charité

Straßenniveau Hannoversche Straße 34.16m ü NHN to a wide range of collaborators. The construction of a new building for BIMSB will BIMSB researchers apply quantitative experimental and theoretical approaches to model systems suitable for high-

+34.15m Bundesministerium für Bildung und Forschung

IV Haus 12 III make it the MDC’s first institutional expansion into the center of Berlin, supporting versenkbare Hauptbahnhof Poller throughput analyses on multiple levels. Model organisms such as Drosophila, nematodes and flatworms, zebrafish and cell BIMSB is fostering and maintaining institutional collaborations with national +34.20m

+34.15m

+34.05m II Bodendecker even closer interactions with major academic and medical institutions in the city aun

+33.95m +34.15m s z Mosaikp aster and international research institutes, universities, and other organizations to Mastleuchten culture are employed as they are particularly amenable to systems wide investigations. Strategies to translate BIMSB research

Sicherhei t I Zufahrt Feuerwehr Asphalt +34.05m Plattenbelag, befahrbar Mosaikp aster

Rasen +34.05m

Aufstell äche +34.48m Feuerwehr Haus 25 und OK Traufe=+28.20m and region. The new building offers open research space for 25 research teams, BIMSB +34.48m Vegetationsinseln mit facilitate joint research projects, staff exchange, access to innovative technologies, and +34.25m OK Dach=+24.30m Sitzelementen to more disease relevant model organisms are undertaken in collaboration with MDC teams working on disease mechanisms or

omatisches Luftansaugbauwerk, u t A Schiebe t versetzt Müllstandort, versetzt 2 Stellplätze +34.25m 9 Fahrradbügel, versetzt

OK Dach=+28.20m +34.40m

Mosaikp aster +34.48m

Stickstotank BIMSB Haupteingang +34.48m and state-of-the-art technologies, as well as communication & conference space. OK Absturzsicherung=+14.20m OK Attika=+13.10m development of joint training activities. IV and other MDC technology platforms. Gas aschen - 50 Fahrradstellplätze lager +11.98m

Müllentsorgung

OK Terrasse=+12.98m Plattenbelag Anlieferung HU Forschungssporthalle Rettungsweg 6 Stufen 17/35

+34.50m Einfriedungsmauer +34.40m +34.25m +11.98m BIMSB research groups will relocate to the central historical Campus Nord of the III Anbindung +34.49m Haus 25 As a core activity, BIMSB has launched an international PhD exchange program 2 Behinderten - stellplätze Schotterrasen +34.95m

Rasen Blockstufe II

HU Haus 25 +34.90m +34.48m Bundeskanzleramt +34.25m

±0.00=34.50m üNN HUB in 2018. Construction has started in March 2015. +34.90m between the MDC and New York University (NYU) to educate the next generation of

Berlin Institute for Medical Systems Biology Levin Monsigny Landschaftsarchitekten GmbH Bauherr: MDC Max-Delbrück-Centrum für Molekulare Medizin Brunnenstraße 181, 10119 Berlin, Telefon: +49 30 44 05 31 84 Gestaltungsplan, Entwurf G E LA03, Stand 28.05.2014, ohne Maßstab E-Mail:F [email protected] raße systems biologists. Ten BIMSB PhD students are able to spend up to two years working

Picture courtesy for background image: Google Maps Picture courtesy of Thomas Willnow Lab and studying at the Center for Genomics and Systems Biology at New York University. Both institutes have a strong reputation in systems biology and students can take advantage of state-of-the-art technology platforms and a training program of specialist CONTACT BIMSB courses and personal development opportunities. More international exchange is foreseen to develop with the MRC CSC (Medical Research Council, Clinical Science Nikolaus Rajewsky, Head of the Berlin Institute for Phone 49 (0) 30 9406 3034 Center) in London. Medical Systems Biology at the MDC Email [email protected] Communication, conferences and training events such as the annual Berlin Summer Jutta Steinkötter, BIMSB Management Address Robert-Rössle-Str. 10, 13125 Berlin, Germany Meeting contribute to a worldwide scientific exchange and network. BIMSB organizes Nadine Ewald, Administrative Assistant Internet www.mdc-berlin.de/en/bimsb lectures together with Berlin’s universities and Summer Schools for interdisciplinary Grietje Krabbe, Graduate Program systems biology education of young researchers. FOUNDING&FUNDING GROUP LEADERS INNOVATIONS &

Medical systems biology research combines various disciplines, technologies and experts. BIMSB group leaders are international scientists, recognized leaders in their field and expert in innovative technologies. Additional to various intra- TECHNOLOGIES institutional collaborations, resulting in a number of shared publications, BIMSB group leaders expand their interactions to regional partners from the Charité, Humboldt University Berlin (HU), Free University Berlin (FU), Max Planck and Leibniz Institutes and international partners such as New York University and MRC CSC London.

Altuna Akalin Marina Chekulaeva Wei Chen Scientific Non-coding RNAs Functional Genomics Bioinformatics and Mechanisms of & Scientific Genomics Platform Cytoplasmic Gene Platform Regulation The Berlin Institute for Medical Systems Biology (BIMSB) is the Systems Biology program of the Max Delbrück Center for Molecular Medicine (MDC). Launched in 2008 with start-up grants from the BMBF and the Senate of Berlin (until 2013), BIMSB now receives MDC institutional funding. BIMSB’s successive international recruitments of BIMSB combines high-throughput technologies and innovative methodologies with Junior and Senior group leaders will reach a total of up to 25 research teams, including Jan-Phillipp Junker Stefan Kempa Markus Landthaler Irmtraud Meyer Quantitative Biology Integrative RNA Biology and RNA Structure scientific expertise in genome, transcriptome, proteome, metabolome and image Proteomics and technology platforms. The teams competed successfully for third party funding from of Developmental Posttranscriptional Modelling analysis as well as bioinformatics in a unique research environment of the MDC and Pattern Formation Metabolomics Regulation local, national and international science funding agencies. Platform partners in Berlin. BIMSB is focused on the elucidation of gene regulatory networks and their impact on BIMSB Technology Platforms currently comprise newest Illumina Sequencing technolo- molecular and cellular mechanisms. This area lies at the heart of today’s biological gy along with a Single Molecule Real Time Platform (Pacific Biosciences), as well as single and biomedical research on health and disease. BIMSB integrates experimental and cell sequencing. Mass spectrometry is represented with ample capacities for quantitative computational research approaches with the central themes of MDC research and proteome and metabolome analysis and automation. Data are processed, analyzed and Uwe Ohler Ana Pombo Stephan Preibisch other partner institutions in Berlin. Computational Epigenetic Microscopy, Image integrated with state-of-the-art computer clusters and -dynamics. Capacities and areas Regulatory Regulation and Analysis and Modeling of technologies are expected to expand with the recruitment of more groups. Genomics Chromatin of Developing SCIENTIFIC MISSION Architecture Organisms The unique potential of BIMSB is not only the application of high-end technologies but also the combination of cutting-edge methodologies such as PAR-CLIP (photo­ activatable-ribonucleoside-enhanced-crosslinking and immunoprecipitation), sorting The overall scientific BIMSB mission is to integrate different levels of gene regulation to better understand how phenotypes of cells and even whole organisms, SILAC (stable isotope labeling by amino acids in in health and disease are linked to genotypes. These levels of gene regulation include chromatin and epigenetic changes culture cells), and Genome architecture mapping, with computational analysis and Robert Zinzen Nikolaus Rajewsky Baris Tursun and (post)transcriptional as well as (post)translational regulation. BIMSB researchers apply quantitative experimental and Systems Biology Systems Biology of Gene Regulation mathematical modelling. Data from the various biological and experimental systems of Neural Tissue theoretical approaches to model systems suitable for multi-level high-throughput analyses as well as targeted approaches. Gene Regulatory and Cell Fate Differentiation are integrated into sophisticated BIMSB databases. In addition we recently established Elements Decision in Drosophila, nematodes, zebrafish, and mammalian systems are instrumental to the BIMSB mission. Major research C. elegans single molecule imaging and live imaging technologies using high-end light-sheet projects address basic cell biology, development, regeneration, stem cell biology, metabolism, genetic variability linked to microscopy. With this BIMSB research helps developing new tools to deepen our cancer as well as cardiovascular and neurological diseases. insights in life – literally speaking.