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Spring 2021 Bulletin
Advancing Access to Civil Justice STEPS TOWARD INTERNATIONAL CLIMATE GOVERNANCE Featuring William Nordhaus, Pinelopi Goldberg, and Scott Barrett HONORING WILLIAM LABOV, RUTH LEHMANN , AND GERTRUD SCHÜPBACH SPRING 2021 SELECT UPCOMING VIRTUAL EVENTS May 6 A Conversation with Architect 27 Reflections on a Full, Consequential, Jeanne Gang and Lucky Life: Science, Leadership, Featuring: Jeanne Gang and Education Featuring: Walter E. Massey (left) in conversation with Don Randel (right) June 14 Lessons Learned from Reckoning with Organizational History Featuring: John J. DeGioia, Brent Leggs, Susan Goldberg, Claudia Rankine, and Ben Vinson 13 Finding a Shared Narrative Hosted by the Library of Congress Featuring: Danielle Allen, winner of the Library’s 2020 Kluge Prize Above: “Our Common Purpose” featuring the Juneteenth flag with one star. Artist: Rodrigo Corral For a full and up-to-date listing of upcoming events, please visit amacad.org/events. SPRING 2021 CONTENTS Flooding beside the Russian River on Westside Road in Healdsburg, Sonoma County, California; February 27, 2019. Features 16 Steps Toward International 38 Honoring Ruth Lehmann and Gertrud Climate Governance Schüpbach with the Francis Amory Prize William Nordhaus, Pinelopi Goldberg, and Scott Barrett Ruth Lehmann and Gertrud Schüpbach 30 Honoring William Labov with the Talcott Parsons Prize William Labov CONTENTS 5 Among the contributors to the Dædalus issue on “Immigration, Nativism & Race” (left to right): Douglas S. Massey (guest editor), Christopher Sebastian Parker, and Cecilia Menjívar Our Work 5 Dædalus Explores Immigration, Nativism & Race in the United States 7 Advancing Civil Justice Access in the 21st Century 7 10 New Reports on the Earnings & Job Outcomes of College Graduates 14 Our Common Purpose in Communities Across the Country Members 53 In Memoriam: Louis W. -
RECENT ADVANCES in BIOLOGY, BIOPHYSICS, BIOENGINEERING and COMPUTATIONAL CHEMISTRY
RECENT ADVANCES in BIOLOGY, BIOPHYSICS, BIOENGINEERING and COMPUTATIONAL CHEMISTRY Proceedings of the 5th WSEAS International Conference on CELLULAR and MOLECULAR BIOLOGY, BIOPHYSICS and BIOENGINEERING (BIO '09) Proceedings of the 3rd WSEAS International Conference on COMPUTATIONAL CHEMISTRY (COMPUCHEM '09) Puerto De La Cruz, Tenerife, Canary Islands, Spain December 14-16, 2009 Recent Advances in Biology and Biomedicine A Series of Reference Books and Textbooks Published by WSEAS Press ISSN: 1790-5125 www.wseas.org ISBN: 978-960-474-141-0 RECENT ADVANCES in BIOLOGY, BIOPHYSICS, BIOENGINEERING and COMPUTATIONAL CHEMISTRY Proceedings of the 5th WSEAS International Conference on CELLULAR and MOLECULAR BIOLOGY, BIOPHYSICS and BIOENGINEERING (BIO '09) Proceedings of the 3rd WSEAS International Conference on COMPUTATIONAL CHEMISTRY (COMPUCHEM '09) Puerto De La Cruz, Tenerife, Canary Islands, Spain December 14-16, 2009 Recent Advances in Biology and Biomedicine A Series of Reference Books and Textbooks Published by WSEAS Press www.wseas.org Copyright © 2009, by WSEAS Press All the copyright of the present book belongs to the World Scientific and Engineering Academy and Society Press. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the Editor of World Scientific and Engineering Academy and Society Press. All papers of the present volume were peer reviewed -
Lates Niloticus) Ecological Risk Screening Summary
U.S. Fish and Wildlife Service Nile Perch (Lates niloticus) Ecological Risk Screening Summary Web Version – September 2014 Photo: © Biopix: N Sloth 1 Native Range, and Status in the United States Native Range From Schofield (2011): “Much of central, western and eastern Africa: Nile River (below Murchison Falls), as well as the Congo, Niger, Volga, Senegal rivers and lakes Chad and Turkana (Greenwood 1966 [cited by Schofield (2011) but not accessed for this report]). Also present in the brackish Lake Mariot near Alexandria, Egypt.” Lates niloticus Ecological Risk Screening Summary U.S. Fish and Wildlife Service – Web Version - 8/14/2012 Status in the United States From Schofield (2011): “Scientists from Texas traveled to Tanzania in 1974-1975 to investigate the introduction potential of Lates spp. into Texas reservoirs (Thompson et al. 1977 [cited by Schofield (2011) but not accessed for this report]). Temperature tolerance and trophic dynamics were studied for three species (L. angustifrons, L. microlepis and L. mariae). Subsequently, several individuals of these three species were shipped to Heart of the Hills Research Station (HOHRS) in Ingram, Texas in 1975 (Rutledge and Lyons 1976 [cited by Schofield (2011) but not accessed for this report]). Also in 1975, Nile perch (L. niloticus) were transferred from Lake Turkana, Kenya, to HOHRS. All fishes were held in indoor, closed-circulating systems (Rutledge and Lyons 1976).” “From 1978 to 1985, Lates spp. was released into various Texas reservoirs (Howells and Garrett 1992 [cited by Schofield (2011) but not accessed for this report]). Almost 70,000 Lates spp. larvae were stocked into Victor Braunig (Bexar Co.), Coleto Creek (Goliad Co.) and Fairfield (Freestone Co.) reservoirs between 1978 and 1984. -
Applied Category Theory for Genomics – an Initiative
Applied Category Theory for Genomics { An Initiative Yanying Wu1,2 1Centre for Neural Circuits and Behaviour, University of Oxford, UK 2Department of Physiology, Anatomy and Genetics, University of Oxford, UK 06 Sept, 2020 Abstract The ultimate secret of all lives on earth is hidden in their genomes { a totality of DNA sequences. We currently know the whole genome sequence of many organisms, while our understanding of the genome architecture on a systematic level remains rudimentary. Applied category theory opens a promising way to integrate the humongous amount of heterogeneous informations in genomics, to advance our knowledge regarding genome organization, and to provide us with a deep and holistic view of our own genomes. In this work we explain why applied category theory carries such a hope, and we move on to show how it could actually do so, albeit in baby steps. The manuscript intends to be readable to both mathematicians and biologists, therefore no prior knowledge is required from either side. arXiv:2009.02822v1 [q-bio.GN] 6 Sep 2020 1 Introduction DNA, the genetic material of all living beings on this planet, holds the secret of life. The complete set of DNA sequences in an organism constitutes its genome { the blueprint and instruction manual of that organism, be it a human or fly [1]. Therefore, genomics, which studies the contents and meaning of genomes, has been standing in the central stage of scientific research since its birth. The twentieth century witnessed three milestones of genomics research [1]. It began with the discovery of Mendel's laws of inheritance [2], sparked a climax in the middle with the reveal of DNA double helix structure [3], and ended with the accomplishment of a first draft of complete human genome sequences [4]. -
Research Development Innovation 2013/2014 Report
Centro Nacional de Biotecnología Campus de Cantoblanco RESEARCH Darwin 3, Madrid 28049, Spain Tel.: [+ 34] 91 585 4500 / Fax: [+ 34] 91 585 4506 DEVELOPMENT www.cnb.csic.es INNOVATION 2013/2014 REPORT INDEX Welcome to the CNB ................................................................................................................................................. 9 Carmen Castresana 1 / Plant Molecular Genetics 13 Genetic and molecular basis of naturally-occurring variation in plant development .............................................. 14 Carlos Alonso-Blanco Plant immunity strategies against microbial pathogen infection .............................................................................. 15 Carmen Castresana Genetic control of shoot branching patterns in plants ............................................................................................. 16 Pilar Cubas Plant-pathogen interaction in viral infections ........................................................................................................... 17 Juan Antonio García / Carmen Simón Genes involved in root architecture and in arsenic phytoremediation .................................................................... 18 Antonio Leyva Tejada Regulation of gene activity in plants: the phosphate starvation rescue system ...................................................... 19 Javier Paz-Ares Light signalling and day length control of potato tuber formation ........................................................................... 20 Salomé -
Kinesin-4 KIF21B Limits Microtubule Growth to Allow Rapid Centrosome
RESEARCH ARTICLE Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells Peter Jan Hooikaas1†, Hugo GJ Damstra1†, Oane J Gros1, Wilhelmina E van Riel1‡, Maud Martin1§, Yesper TH Smits2, Jorg van Loosdregt2, Lukas C Kapitein1, Florian Berger1*, Anna Akhmanova1* 1Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands; 2Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands Abstract When a T cell and an antigen-presenting cell form an immunological synapse, rapid dynein-driven translocation of the centrosome toward the contact site leads to reorganization of microtubules and associated organelles. Currently, little is known about how the regulation of *For correspondence: microtubule dynamics contributes to this process. Here, we show that the knockout of KIF21B, a [email protected] (FB); kinesin-4 linked to autoimmune disorders, causes microtubule overgrowth and perturbs [email protected] (AA) centrosome translocation. KIF21B restricts microtubule length by inducing microtubule pausing typically followed by catastrophe. Catastrophe induction with vinblastine prevented microtubule †These authors contributed overgrowth and was sufficient to rescue centrosome polarization in KIF21B-knockout cells. equally to this work Biophysical simulations showed that a relatively small number of KIF21B molecules can restrict ‡ Present address: Netherlands mirotubule length and promote an imbalance -
Female Fellows of the Royal Society
Female Fellows of the Royal Society Professor Jan Anderson FRS [1996] Professor Ruth Lynden-Bell FRS [2006] Professor Judith Armitage FRS [2013] Dr Mary Lyon FRS [1973] Professor Frances Ashcroft FMedSci FRS [1999] Professor Georgina Mace CBE FRS [2002] Professor Gillian Bates FMedSci FRS [2007] Professor Trudy Mackay FRS [2006] Professor Jean Beggs CBE FRS [1998] Professor Enid MacRobbie FRS [1991] Dame Jocelyn Bell Burnell DBE FRS [2003] Dr Philippa Marrack FMedSci FRS [1997] Dame Valerie Beral DBE FMedSci FRS [2006] Professor Dusa McDuff FRS [1994] Dr Mariann Bienz FMedSci FRS [2003] Professor Angela McLean FRS [2009] Professor Elizabeth Blackburn AC FRS [1992] Professor Anne Mills FMedSci FRS [2013] Professor Andrea Brand FMedSci FRS [2010] Professor Brenda Milner CC FRS [1979] Professor Eleanor Burbidge FRS [1964] Dr Anne O'Garra FMedSci FRS [2008] Professor Eleanor Campbell FRS [2010] Dame Bridget Ogilvie AC DBE FMedSci FRS [2003] Professor Doreen Cantrell FMedSci FRS [2011] Baroness Onora O'Neill * CBE FBA FMedSci FRS [2007] Professor Lorna Casselton CBE FRS [1999] Dame Linda Partridge DBE FMedSci FRS [1996] Professor Deborah Charlesworth FRS [2005] Dr Barbara Pearse FRS [1988] Professor Jennifer Clack FRS [2009] Professor Fiona Powrie FRS [2011] Professor Nicola Clayton FRS [2010] Professor Susan Rees FRS [2002] Professor Suzanne Cory AC FRS [1992] Professor Daniela Rhodes FRS [2007] Dame Kay Davies DBE FMedSci FRS [2003] Professor Elizabeth Robertson FRS [2003] Professor Caroline Dean OBE FRS [2004] Dame Carol Robinson DBE FMedSci -
Beendigung Der Entzündungsreaktion Durch Interleukin-9 Sezernierende
Beendigung der Entz¨undungsreaktion durch Interleukin-9 sezernierende angeborene Lymphozyten Der Naturwissenschaftlichen Fakult¨at der Friedrich-Alexander-Universit¨at Erlangen-Nurnberg¨ zur Erlangung des Doktorgrades Dr. rer. nat. vorgelegt von Simon Rauber Als Dissertation genehmigt von der Naturwissenschaftlichen Fakult¨at der Friedrich-Alexander-Universit¨at Erlangen-Nurnberg¨ Tag der mundlichen¨ Prufung:¨ 02. 05. 2919 Vorsitzender des Promotionsorgans: Prof. Dr. Georg Kreimer Gutachter: Prof. Dr. Steffen Backert Prof. Dr. Georg Schett Resolution of inflammation by interleukin-9 producing innate lymphoid cells To the Faculty of Natural Sciences of the Friedrich-Alexander-University Erlangen-Nuremberg for the obtainment of the academic degree doctor rerum naturalium (Dr. rer. nat.) submitted by Simon Rauber Approved by the Faculty of Natural Sciences of the Friedrich-Alexander-University Erlangen-Nuremberg Date of oral examination: 02. 05. 2019 Chairman of examination board: Prof. Dr. Georg Kreimer Referees: Prof. Dr. Steffen Backert Prof. Dr. Georg Schett Table of contents 1 Deutsche Kurzfassung1 2 English abstract3 3 Introduction 5 3.1 Innate lymphoid cells and the bridge between primary and adaptive immune response6 3.1.1 The discovery . .7 3.1.2 The classification of innate lymphoid cells and their integration into the im- mune system . 11 3.1.3 Are innate lymphoid cells only innate mirrors or fully-fledged immune cells . 12 3.2 The interleukin-9 . 15 3.2.1 The cellular source of interleukin-9 . 15 3.2.2 The immune-modulatory capacities of interleukin-9 . 17 3.2.2.1 Interleukin-9 in infection, tumour and allergy . 18 3.2.2.2 Interleukin-9 in autoimmune diseases . -
REPORTER No 6396 W E D N E S D Ay 23 S E P T E M B E R 2015 V O L C X Lv I N O 1
CAMBRIDGE UNIVERSITY REPORTER NO 6396 W ED N E S D AY 23 S EPTEMBER 2015 V OL CXLV I N O 1 CONTENTS Notices Notices by Faculty Boards, etc. Calendar 2 Natural Sciences Tripos, Part II (Biological Notice of a Discussion on Tuesday, 13 October and Biomedical Sciences), 2015–16 11 2015 2 Natural Sciences Tripos, Part III (Experimental Preacher at Mere’s Commemoration in 2016 2 and Theoretical Physics) and Master of Nomination of the Proctors and Deputy Advanced Studies in Physics, 2015–16 12 Proctors for 2015–16 2 Form and conduct of examinations, 2016 Annual Reports 2 Asian and Middle Eastern Studies Tripos, Examination results statistics 2 Part II, 2016: correction 13 Vacancies, appointments, etc. Obituaries Electors to the Professorship of Comparative Obituary Notices 14 Philology 3 Graces Electors to the Professorship of Immunology 3 Grace submitted to the Regent House on Electors to the Sir Patrick Sheehy 23 September 2015 14 Professorship of International Relations 3 Acta Electors to the Professorship of Medieval History 4 Approval of Grace submitted to the Regent Electors to the William Wyse Professorship of House on 29 July 2015 14 Social Anthropology 4 Vacancies in the University 4 End of the Official Part of the ‘Reporter’ Elections, appointments, reappointment, and College Notices grants of title 5 Elections 15 Awards, etc. Vacancies 16 Scholarships and Prizes, etc. awarded 7 Other Notices 17 Events, courses, etc. Notice by the University Bellringer 17 Announcement of lectures, seminars, etc. 8 External Notices Notices by the General Board University of Oxford 17 Regulations for the University Library 9 The Cambridge Humanities Research Grants Scheme 9 Regulations for examinations Classical Tripos, Part II 10 Modern and Medieval Languages Tripos, Part IB 10 Bachelor of Theology for Ministry 10 PLISUB HED BY AUTHORITY 2 CAMBRIDGE UNIVERSITY REPORTER 23 September 2015 NOTICES Calendar 1 October, Thursday. -
Pipsqueak, an Early Acting Member of the Posterior Group of Genes, Affects Vasa Level and Germ Cell-Somatic Cell Interaction in the Developing Egg Chamber
Development 119, 1187-1202 (1993) 1187 Printed in Great Britain © The Company of Biologists Limited 1993 pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber Vivian Siegel*, Thomas A. Jongens, Lily Yeh Jan and Yuh Nung Jan Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94143-0724, USA *Author for correspondence SUMMARY We have identified a new member of the posterior group through vasa; molecular studies indicate that pipsqueak of genes, which we call pipsqueak. We show that affects vasa level in the ovary. We compare vasa and pipsqueak acts after the establishment of the oskar pipsqueak mutant phenotypes in order to determine posterior anchor but before the localization of vasa whether pipsqueak acts solely through vasa, and present protein during oogenesis. Characterization of multiple a model for the role of pipsqueak in posterior pattern alleles at the pipsqueak locus shows that pipsqueak, like formation. vasa, is required for early stages of oogenesis, including but not limited to formation of the egg chamber and pro- gression through Stage 6 of oogenesis. Genetic interac- Key words: Drosophila, oogenesis, posterior pattern formation, tion studies suggest that pipsqueak acts at least partially pipsqueak, vasa INTRODUCTION known collectively as posterior group genes of the grand- childless class, all seem to affect the formation of electron Pattern formation along the anteroposterior axis of the dense particles called polar granules, which are thought to Drosophila melanogaster embryo is initiated prior to fertil- consist of both protein and RNA, and which are localized to ization. -
Ecological Assessments in the B+WISER Sites
Ecological Assessments in the B+WISER Sites (Northern Sierra Madre Natural Park, Upper Marikina-Kaliwa Forest Reserve, Bago River Watershed and Forest Reserve, Naujan Lake National Park and Subwatersheds, Mt. Kitanglad Range Natural Park and Mt. Apo Natural Park) Philippines Biodiversity & Watersheds Improved for Stronger Economy & Ecosystem Resilience (B+WISER) 23 March 2015 This publication was produced for review by the United States Agency for International Development. It was prepared by Chemonics International Inc. The Biodiversity and Watersheds Improved for Stronger Economy and Ecosystem Resilience Program is funded by the USAID, Contract No. AID-492-C-13-00002 and implemented by Chemonics International in association with: Fauna and Flora International (FFI) Haribon Foundation World Agroforestry Center (ICRAF) The author’s views expressed in this publication do not necessarily reflect the views of the United States Agency for International Development or the United States Government. Ecological Assessments in the B+WISER Sites Philippines Biodiversity and Watersheds Improved for Stronger Economy and Ecosystem Resilience (B+WISER) Program Implemented with: Department of Environment and Natural Resources Other National Government Agencies Local Government Units and Agencies Supported by: United States Agency for International Development Contract No.: AID-492-C-13-00002 Managed by: Chemonics International Inc. in partnership with Fauna and Flora International (FFI) Haribon Foundation World Agroforestry Center (ICRAF) 23 March -
Annual Report 2010 © Copyright 2011
Centre for Genomic Regulation Annual Report 2010 © Copyright 2011 Produced by: Department of Communication & Public Relations Centre for Genomic Regulation (CRG) Dr. Aiguader, 88 08003 Barcelona, Spain www.crg.eu Texts and graphics: CRG Researchers, Department of Communication and Public Relations Graphic Design: Genoma ArtStudio SCP (www.genoma-artstudio.com) Photography: Ivan Martí Printing: Novoprint, S.A. Legal deposit: B-24966-2011 CONTENTS CRG Scientific Structure 6 CRG Core Facilities Structure 8 CRG Management Structure 10 CRG Scientific Advisory Board (SAB) 12 CRG Business Board 13 Year Retrospect by the Director of the CRG: Miguel Beato 14 Research Programmes Gene Regulation 16 > Chromatin and gene expression 18 > Regulation of alternative pre-mRNA splicing during cell differentiation, development and disease 22 > Regulation of protein synthesis in eukaryotes 26 > Translational control of gene expression 29 Differentiation and Cancer 34 > Hematopoietic differentiation and stem cell biology 36 > Reprogramming and regeneration 40 > Epigenetics events in cancer 43 > Epithelial homeostasis and cancer 48 > Mechanisms of cancer and aging 51 Genes and Disease 54 > Genetic causes of disease 56 > Gene therapy 65 > Gene Function and murine models of disease 69 > Neurobehavioral phenotyping of mouse models of disease 73 > Genomic and epigenomic variation in disease 77 Bioinformatics and Genomics 82 > Bioinformatics and genomics 84 > Comparative bioinformatics 92 > Comparative genomics 96 > Evolutionary genomics 101 > Gene function and evolution