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Annual Report 2010 © Copyright 2011 Centre for Genomic Regulation Annual Report 2010 © Copyright 2011 Produced by: Department of Communication & Public Relations Centre for Genomic Regulation (CRG) Dr. Aiguader, 88 08003 Barcelona, Spain www.crg.eu Texts and graphics: CRG Researchers, Department of Communication and Public Relations Graphic Design: Genoma ArtStudio SCP (www.genoma-artstudio.com) Photography: Ivan Martí Printing: Novoprint, S.A. Legal deposit: B-24966-2011 CONTENTS CRG Scientific Structure 6 CRG Core Facilities Structure 8 CRG Management Structure 10 CRG Scientific Advisory Board (SAB) 12 CRG Business Board 13 Year Retrospect by the Director of the CRG: Miguel Beato 14 Research Programmes Gene Regulation 16 > Chromatin and gene expression 18 > Regulation of alternative pre-mRNA splicing during cell differentiation, development and disease 22 > Regulation of protein synthesis in eukaryotes 26 > Translational control of gene expression 29 Differentiation and Cancer 34 > Hematopoietic differentiation and stem cell biology 36 > Reprogramming and regeneration 40 > Epigenetics events in cancer 43 > Epithelial homeostasis and cancer 48 > Mechanisms of cancer and aging 51 Genes and Disease 54 > Genetic causes of disease 56 > Gene therapy 65 > Gene Function and murine models of disease 69 > Neurobehavioral phenotyping of mouse models of disease 73 > Genomic and epigenomic variation in disease 77 Bioinformatics and Genomics 82 > Bioinformatics and genomics 84 > Comparative bioinformatics 92 > Comparative genomics 96 > Evolutionary genomics 101 > Gene function and evolution 105 Cell and Developmental Biology 110 > Intracellular compartmentation 112 > Microtubule function and cell division 118 > Sensory cell biology and organogenesis 122 > Coordination of cytokinesis with chromosome segregation 126 > Biomechanics of morphogenesis 129 > Organelle biogenesis and homeostasis 132 136 Systems Biology 138 > Design of biological systems 142 > Systems analysis of development 146 > Gene network engineering 150 > Genetic systems 154 > Sensory systems and behaviour 158 > Comparative analysis of developmental systems 163 > Antibody Project 164 Core Facilities Core Facilities: > Genomics Unit 166 Genotyping Unit 173 Ultrasequencing Unit 176 Microarrays Unit 180 > CRG/UPF Proteomics Unit 183 > CRG/UPF Advanced Light Microscopy Unit 186 > High-Throughput Screening Unit 189 > Bioinformatics Unit 192 > CRG/UPF FACS Unit In-house Services: 196 > Histology Service 199 > Protein Expression Service 202 CRG Transversal Institutional Project Highlights: 205 > Gene Regulation Programme: “New functions for new genes: non-coding RNAs get into the action” 206 > Differentiation and Cancer Programme: “To be or not to be, that is the question”: the role of the ZRF1 gene in embryonic development and carcinogenesis” 207 > Genes and Disease Programme: “A new mechanism involved in the regulation of stem cells in the adult brain” 208 > Bionformatics and Genomics Programme: “Big bang in the protein universe” 209 > Cell and Developmental Biology Programme: “A new secretory pathway for proteins” 210 > Systems Biology Programme: “New success for computational biology: new discoveries about the limb development ” 212 Appendix 1: > IX CRG Annual Symposium: “Medical Genome Sequencing: Understanding the Genomes of Disease” 214 Appendix 2: > PRBB-CRG Sessions and Programme & Core Facilities Seminars 220 Appendix 3: > Funding 223 Appendix 4: > Personnel Evolution 226 Appendix 5: > Press Clipping SCIENTIFIC STRUCTURE BOARD OF TRUSTEES INTERNATIONAL COLLABORATION DIRECTOR & SPONSORSHIP OFFICE Miguel Beato Michela Bertero DEPUTY DIRECTOR Luis Serrano SCIENTIFIC FACULTY BOARD SCIENTIFIC BUSINESS BOARD ADVISORY BOARD EXECUTIVE BOARD COMMITTEE GENE BIOINFORMATICS CELL AND SYSTEMS DIFFERENTIATION GENES REGULATION AND GENOMICS DEV. BIOLOGY BIOLOGY AND CANCER AND DISEASE MIGUEL BEATO RODERIC GUIGÓ VIVEK MALHOTRA LUIS SERRANO THOMAS GRAF XAVIER ESTIVILL Coordinator Coordinator Coordinator Coordinator Coordinator Coordinator INTRACELLULAR HEMATOPOIETIC CHROMATIN AND BIOINFORMATICS DESIGN OF COMPARTMENTATION DIFFERENTIATION AND GENE EXPRESSION AND GENOMICS BIOLOGICAL SYSTEMS GENETIC CAUSES STEM CELL BIOLOGY OF DISEASE RODERIC GUIGÓ VIVEK MALHOTRA LUIS SERRANO MIGUEL BEATO Group Leader THOMAS GRAF Group Leader Group Leader Group Leader XAVIER ESTIVILL Group Leader Group Leader REGULATION MICROTUBULES COMPARATIVE SYSTEMS ANALYSIS REPROGRAMMING OF ALTERNATIVE FUNCTION AND CELL GENE THERAPY BIOINFORMATICS OF DEVELOPMENT & REGENERATION PRE-MRNA SPLICING DIVISION CRISTINA FILLAT CEDRIC NOTREDAME JAMES SHARPE MARIA PIA COSMA Group Leader JUAN VALCÁRCEL Group Leader ISABELLE VERNOS Group Leader Group Leader Group Leader Group Leader NEUROBEHAVIORAL TRANSLATIONAL COMPARATIVE SENSORY CELL BIOLOGY GENE NETWORK PHENOTYPING OF CONTROL OF GENE EPIGENETICS EVENTS GENOMICS AND ORGANOGENESIS ENGINEERING IN CANCER MOUSE MODELS EXPRESSION OF DISEASE TONI GABALDÓN HERNAN LOPEZ-SCHIER MARK ISALAN RAÚL MÉNDEZ LUCIANO DI CROCE Group Leader Group Leader Group Leader Group Leader MARA DIERSSEN Group Leader Group Leader EPITHELIAL GENE FUNCTION REGULATION OF CYTOKINESIS AND HOMEOSTASIS AND MURINE MODELS PROTEIN SYNTHESIS EVOLUTIONARY GENETIC SYSTEMS GENOMICS CHROMOSOME SEGRE- AND CANCER OF DISEASE IN EUKARYOTES GATION BEN LEHNER FYODOR KONDRASHOV Group Leader SALVADOR SUSANA DE LA LUNA FÁTIMA GEBAUER MANUEL MENDOZA Group Leader Group Leader AZNAR-BENITAH MARIONA ARBONÉS Group Leader Group Leader Group Leaders GENE FUNCTION BIOMECHANICS SENSORY SYSTEMS MECHANISMS OF GENOMIC & EPIGENOMIC & EVOLUTION OF MORPHOGENESIS AND BEHAVIOUR CANCER AND AGING VARIATION IN DISEASE GIAN GAETANO JÉRÔME SOLON STEPHAN OSSOWSKI Group Leader MATTHIEU LOUIS BILL KEYES TARTAGLIA Group Leader Group Leader Group Leader Group Leader ORGANELLE COMPARATIVE BIOGENESIS ANALYSIS OF & HOMEOSTASIS DEVELOPMENTAL SYSTEMS PEDRO CARVALHO Group Leader JOHANNES JÄGER Group Leader CORE FACILITIES STRUCTURE BOARD OF TRUSTEES DIRECTOR CEO Miguel Beato Marian Marrodan CORE FACILITIES Doris Meder Director GENOMICS UNIT PROTEIN HISTOLOGY PROTEOMICS FACS UNIT ADVANCED LIGHT BIOINFORMATICS HTS/ROBOTICS MICROSCOPY EXPRESSION (In-House Service) UNIT (CRG/UPF) (CRG/UPF) UNIT UNIT (In-House Service) UNIT (CRG/UPF) GENOTYPING UNIT SALVADOR HENRIK MOLINA ÒSCAR FORNAS (UPF) GUGLIELMO ROMA DORIS MEDER MICHELA BERTERO Unit Leader TIMO ZIMMERMANN AZNAR-BENITAH Unit Leader Unit Leader Unit Manager MAGDA MONTFORT Manager Manager Unit Leader Unit Manager ............................... MICROARRAYS UNIT ANNA FERRER Unit Manager ............................... ULTRASEQUEN- CING UNIT HEINZ HIMMELBAUER Unit Leader . Annual Report 2010 .9 MANAGEMENT STRUCTURE BOARD OF TRUSTEES CONTROLLER Jordi Murlà DIRECTOR ASSISTANT DIRECTOR CEO Reyes Perza Miguel Beato Marian Marrodán CEO ASSISTANT Ester Montava COMMUNICATION FINANCES AND HUMAN GENERAL TECHNOLOGY SECRETARIAT LEGAL GRANTS RESEARCH ICT AND PUBLIC OFFICE RESOURCES SERVICES TRANSFER & RECEPTION DEPARTMENT EVA DEL PINTO DAVID CAMARGO RELATIONS BRUNA VIVES DAVID ORDAZ JOSEP QUERALT XAVIER RÚBIES ESTER MONTAVA CRISTINA CASAUS GLORIA LLIGADAS EUROPEAN & HELPDESK HR-PERSONNEL INTERNATIONAL PRESS OFFICER MANAGEMENT ENGINEERING FUNDING ISMAEL DE MINGO & SCIENCE PROJECT MANAGER SECRETARIAT LEGAL DEPT. SUPPORT DISSEMINATION SUPPORT DIEGO MELLIBOVSKY GLORIA FREIXAS SILVIA TÓRTOLA BRUNA VIVES JORDI PAIRÓ MARC GONZÁLEZ LAIA CENDRÓS BARBARA FERREIRA ACCOUNTING CLARA LÓPEZ XAVIER COSMES MAGALÍ BARTOMEUS GEMMA PÉREZ ENRIC GUMMÀ RUT CARBONELL MARÍA ROZAS ROMINA GARRIDO ANNA PAYTUVÍ ALBA SHAW VERÓNICA JAREÑO HR-FELLOWSHIP NATIONAL FUNDING SYSTEMS LAURA FLORES AND STUDENTS ARCHITECTURE SCIENCE TT TECHNICIAN ARANTXA FERRER MANAGEMENT DISSEMINATION EVA NAVARRETE YANN DUBLANCHE PURCHASING MARC ELIAS MARTA SALLÉS NURIA JANÉ AND LOGISTICS ANNICK LABEEUW MARC GONZÁLEZ SERGI REPULLO MIREIA PÉREZ MONTSERRAT ESTAPÉ CORE FACILITIES DAVID RODRÍGUEZ ERP TECHNICAL ADMINISTRATION CONFERENCES ACADEMIC AFFAIRS PROJECT HR SUPPORT RECEPTION JAUME BACARDIT & EVENTS IMMA FALERO JOSE ARCO BÁRBARA FERREIRA ISABEL JURADO JUAN CARLOS BLANKA WYSOCKA GÓMEZ WEB CONTROL DEVELOPMENT SCIENTIFIC AND PROJECTS AREA EQUIPMENTS JUSTIFICATON DAVID CASTILLO NICOLA COLLU IGNASI PLA GEMMA SALVADÓ MARIANA MORLANS STEFAN PONISCH ENRIC GUMMÀ EVA DEL PINTO BdG CLUSTER JOAN CONANGLA SYSTEM MAINTENANCE OLGA JUDERÍAS ADMINISTRATION ÒSCAR GONZÁLEZ JOSEP QUERALT JUDITH FLO WORKING RISKS / SYSTEMS RADIOACTIVITY / ADMINISTRATION WASTES DAVID CAMARGO SONIA ALCÁZAR MªJOSÉ ROMA EiPMC ARANTXA VENTURA ELISABETH MUÑOZ MARTA POU SCIENTIFIC ADVISORY BOARD (SAB) Chairman Dr. Kai Simons Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany Members Dr. Stylianos Emmanuel Antonarakis Medical Genetics, University of Geneva, Geneva, Switzerland Dr. Michael Ashburner European Bioinformatics Institute-EMBL Outstation, Department of Genetics, University of Cambridge, Cambridge, United Kingdom Dr. Peer Bork Structural & Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany Dr. Tim Hunt Cancer Research UK, Hearts, United Kingdom Dr. Walter Kolch Systems Biology Ireland & Conway Institute, University College, Dublin, Ireland Dr. Tony Kouzarides The Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, United Kingdom Dr. Iain Mattaj European Molecular Biology Laboratory (EMBL), Heidelberg, Germany Dr. Joan Modolell Center of Molecular Biology “Severo Ochoa”, CSIC & Autonomous University of Madrid, Madrid, Spain Dr. Wolf Reik Babraham Institute Cambridge, Department
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