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CDB 2003Annual Report ISSN 1349-0494 RIKEN Center for Developmental Biology RIKEN Center for Developmental Biology 2003 Annual Report 2003 Annual Report http://www.cdb.riken.jp CENTER FOR DEVELOPMENTAL BIOLOGY (CDB) 2-2-3 MINATOJIMA-MINAMIMACHI, CHUO-KU KOBE, 650-0047 JAPAN PHONE: +81-78-306-0111 FAX: +81-78-306-0101 EMAIL: [email protected] Production Text Douglas Sipp Content Development Naoki Namba Douglas Sipp Design TRAIS K. K. Photography Yutaka Doi On The Cover Terminal branch of the Drosophila trachea. A single terminal cell labeled with GFP (green) with a large polyploid nucleus (purple) spreads numerous cytoplasmic tubules with intracellular lumen (tracheole) over the surface of the larval gut. PHOTO: Shigeo Hayashi All contents copyright (c) RIKEN Center for Developmental Biology, 2004. Printed in Japan Printed on 100% Recycled Paper Contents ■ Organization ……………………………………………………… 1 ■ Message from the ……………………………………… Director 2/3 ■ 2003 Highlights …………………………………………………… 4/5 RIKEN Core Program ■ Evolutionary Regeneration Biology (Kiyokazu Agata) 8/9 Center for Developmental Biology ■ Vertebrate Body Plan (Shinichi Aizawa) 10/11 ■ Morphogenetic Signaling (Shigeo Hayashi) 12/13 ■ Cell Asymmetry (Fumio Matsuzaki) 14/15 ■ Stem Cell Biology (Shin-ichi Nishikawa) 16/17 Deputy Directors ■ Organogenesis and Neurogenesis (Yoshiki Sasai) 18/19 Shin-ichi Nishikawa Shinichi Aizawa ■ Cell Adhesion and Tissue Patterning (Masatoshi Takeichi) 20/21 Director Masatoshi Takeichi Creative Research Promoting Program Institutional Review Board ■ Stem Cell Translational Research (Takayuki Asahara) 24/25 ■ Neuronal Differentiation and Regeneration (Hideki Enomoto) 26/27 Advisory Council ■ Neural Network Development (Chihiro Hama) 28/29 Igor Dawid, Chair ■ Vertebrate Axis Formation (Masahiko Hibi) 30/31 Laboratory of Molecular Genetics National Institute of Child Health and Human Development, NIH (USA) ■ Positional Information (Shigeru Kondo) 32/33 William Chia Evolutionary Morphology (Shigeru Kuratani) 34/35 MRC Center for Developmental Neurobiology (UK) ■ Elaine Fuchs ■ Sensory Development (Raj Ladher) 36/37 Howard Hughes Medical Institute Rockefeller University (USA) ■ Germline Development (Akira Nakamura) 38/39 Hajime Fujisawa ■ Chromatin Dynamics (Jun-ichi Nakayama) 40/41 Division of Biological Science Nagoya University Graduate School of Science (Japan) ■ Cell Migration (Kiyoji Nishiwaki) 42/43 Peter Gruss Department of Molecular Cell Biology ■ Pluripotent Cell Studies (Hitoshi Niwa) 44/45 Max Planck Institute for Biophysical Chemistry (Germany) ■ Mammalian Epigenetic Studies (Masaki Okano) 46/47 Yoshiki Hotta National Institute of Genetics (Japan) ■ Mammalian Molecular Embryology (Tony Perry) 48/49 Yoichi Nabeshima ■ Embryonic Induction (Hiroshi Sasaki) 50/51 Department of Pathology and Tumor Biology Kyoto University Graduate School of Medicine (Japan) ■ Cell Fate Decision (Hitoshi Sawa) 52/53 Tatsutoshi Nakahata Department of Pediatrics ■ Developmental Genomics (Asako Sugimoto) 54/55 Kyoto University Graduate School of Medicine (Japan) ■ Body Patterning (Yoshiko Takahashi) 56/57 Austin Smith Center for Genome Research 58/59 University of Edinburgh (UK) ■ Genomic Reprogramming (Teruhiko Wakayama) Yoshimi Takai 2003 New Faces Department of Molecular Biology and Biochemistry Osaka University Graduate School/Faculty of Medicine ■ Mammalian Germ Cell Biology (Mitinori Saitou) 60 ■ Systems Biology (Hiroki R. Ueda) 61 Supporting Laboratories ■ Cellular Morphogenesis (Shigenobu Yonemura) 64/65 ■ Animal Resources and Genetic Engineering (Shinichi Aizawa) / Sequencing Lab 66/67 r e ■ Animal Facility & Research Aquarium 68 h d a L j a ■ Budget & Staff ……………………………………………………… 70 R : O ■ Collaborations & Affiliations ……………………………………… 71 T O H ■ Leading Project in ……………………… Regenerative Medicine 72/73 P . k ic ■ Seminars ……………………………………………………… 74/75 h c e th ■ CDB Symposium ……………………………………………………… 76 f o r a e le d id M RIKEN CDB 2003 Annual Report 1 Contents ■ Organization ……………………………………………………… 1 ■ Message from the ……………………………………… Director 2/3 ■ 2003 Highlights …………………………………………………… 4/5 RIKEN Core Program ■ Evolutionary Regeneration Biology (Kiyokazu Agata) 8/9 Center for Developmental Biology ■ Vertebrate Body Plan (Shinichi Aizawa) 10/11 ■ Morphogenetic Signaling (Shigeo Hayashi) 12/13 ■ Cell Asymmetry (Fumio Matsuzaki) 14/15 ■ Stem Cell Biology (Shin-ichi Nishikawa) 16/17 Deputy Directors ■ Organogenesis and Neurogenesis (Yoshiki Sasai) 18/19 Shin-ichi Nishikawa Shinichi Aizawa ■ Cell Adhesion and Tissue Patterning (Masatoshi Takeichi) 20/21 Director Masatoshi Takeichi Creative Research Promoting Program Institutional Review Board ■ Stem Cell Translational Research (Takayuki Asahara) 24/25 ■ Neuronal Differentiation and Regeneration (Hideki Enomoto) 26/27 Advisory Council ■ Neural Network Development (Chihiro Hama) 28/29 Igor Dawid, Chair ■ Vertebrate Axis Formation (Masahiko Hibi) 30/31 Laboratory of Molecular Genetics National Institute of Child Health and Human Development, NIH (USA) ■ Positional Information (Shigeru Kondo) 32/33 William Chia Evolutionary Morphology (Shigeru Kuratani) 34/35 MRC Center for Developmental Neurobiology (UK) ■ Elaine Fuchs ■ Sensory Development (Raj Ladher) 36/37 Howard Hughes Medical Institute Rockefeller University (USA) ■ Germline Development (Akira Nakamura) 38/39 Hajime Fujisawa ■ Chromatin Dynamics (Jun-ichi Nakayama) 40/41 Division of Biological Science Nagoya University Graduate School of Science (Japan) ■ Cell Migration (Kiyoji Nishiwaki) 42/43 Peter Gruss Department of Molecular Cell Biology ■ Pluripotent Cell Studies (Hitoshi Niwa) 44/45 Max Planck Institute for Biophysical Chemistry (Germany) ■ Mammalian Epigenetic Studies (Masaki Okano) 46/47 Yoshiki Hotta National Institute of Genetics (Japan) ■ Mammalian Molecular Embryology (Tony Perry) 48/49 Yoichi Nabeshima ■ Embryonic Induction (Hiroshi Sasaki) 50/51 Department of Pathology and Tumor Biology Kyoto University Graduate School of Medicine (Japan) ■ Cell Fate Decision (Hitoshi Sawa) 52/53 Tatsutoshi Nakahata Department of Pediatrics ■ Developmental Genomics (Asako Sugimoto) 54/55 Kyoto University Graduate School of Medicine (Japan) ■ Body Patterning (Yoshiko Takahashi) 56/57 Austin Smith Center for Genome Research 58/59 University of Edinburgh (UK) ■ Genomic Reprogramming (Teruhiko Wakayama) Yoshimi Takai 2003 New Faces Department of Molecular Biology and Biochemistry Osaka University Graduate School/Faculty of Medicine ■ Mammalian Germ Cell Biology (Mitinori Saitou) 60 ■ Systems Biology (Hiroki R. Ueda) 61 Supporting Laboratories ■ Cellular Morphogenesis (Shigenobu Yonemura) 64/65 ■ Animal Resources and Genetic Engineering (Shinichi Aizawa) / Sequencing Lab 66/67 r e ■ Animal Facility & Research Aquarium 68 h d a L j a ■ Budget & Staff ……………………………………………………… 70 R : O ■ Collaborations & Affiliations ……………………………………… 71 T O H ■ Leading Project in ……………………… Regenerative Medicine 72/73 P . k ic ■ Seminars ……………………………………………………… 74/75 h c e th ■ CDB Symposium ……………………………………………………… 76 f o r a e le d id M RIKEN CDB 2003 Annual Report 1 Center for Developmental Biology Message from the Director Masatoshi Takeichi Director, CDB The days leading up to the year's end tend to be chaotic, but they also provide one with a valuable Domestically, Japan saw increased stimulus to look back on milestones passed and ahead to new objectives. As 2003 comes to a attention to a number of related issues and close, it's good to be able to take stock of the achievements made by researchers at the RIKEN Cen- research fields. The national government ter for Developmental Biology, the challenges we face in the years ahead, and the state of our rapid- unveiled plans for the Leading Projects, initiatives set ly evolving science. This year has seen the emergence of news and civic issues that have placed up to fund mid-term research into a number of key areas the fields of developmental biology, regeneration and regenerative medicine frequently in the identified as having the potential to improve public health, wel- spotlight and sometimes at the center of controversy on the world stage, a position accompanied by fare and economic well-being. As the largest center for the study of all the advantages and drawbacks that public prominence entails. developmental biology in Japan, the CDB received funding to carry out Leading Project research into potential applications for stem cells in regen- For us at the CDB, the year began in March with the unqualified (and uncontroversial) success of erative medicine. Embryonic stem cells also featured in the national news our first annual symposium on The Origin and Formation of Multicellular Systems, a three-day meet- this year, which saw the first establishment of a new line of human ES cells by ing of more than 200 distinguished speakers, poster presenters and attendees who gathered to dis- a Japanese laboratory in Kyoto University. ES cells represent a biological cuss metazoan biology, from its single-celled forebears to its greatest evolutionary achievement in resource of potentially revolutionary importance, but whose study demands careful the formation of neural networks comprising billions of cells. We look forward to hosting more such consideration and ethical restraint. The use of human ES cells is for biomedical meetings on a yearly basis, beginning with our next symposium, on Developmental Remodeling, in research is permitted in Japan, and in 2003 a number of CDB labs applied for permis- March of 2004, which will be held on the CDB campus in an auditorium
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