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Research Report 2014 Research Report 2014 Research Report 2014 Table of Contents Inhalt II Table of Contents Inhalt VIII Introduction by the Scientific Director Vorwort des Wissenschaftlichen Vorstands XII Editorial Remarks Redaktionelle Hinweise 1 Cardiovascular and Metabolic Disease Coordinator: Norbert Hübner 4 Mathematical Cell Physiology Martin Falcke 6 Neuromuscular and Cardiovascular Cell Biology Michael Gotthardt 8 Angiogenesis and Cardiovascular Pathology Ferdinand le Noble 10 Molecular Muscle Physiology Ingo Morano 14 Electrochemical Signaling in Development and Disease Daniela Panáková 16 Anchored Signalling Walter Rosenthal, Enno Klußmann 20 Experimental and Translational Kidney Research Kai Schmidt-Ott 22 Zebrafish Cardiovascular Developmental Genetics Salim Seyfried 24 Molecular and Cellular Basis of Embryonic Development Francesca M. Spagnoli 26 Molecular Cardiovascular Research Thomas Willnow 30 Mathematical Modelling of Cellular Processes Jana Wolf 32 Cardiovascular Hormones Michael Bader 36 Genetics and Genomics of Cardiovascular Diseases Norbert Hübner 40 Mobile DNA Zsuzsanna Izsvak 42 Molecular Genetics of Chronic Inflammation and Allergic Disease Young-Ae Lee 44 Hypertension Genetics, Regulators, and Environment Friedrich C. Luft 48 Ultrahigh Field Magnetic Resonance (UHF-MR) Thoralf Niendorf 52 Cell Signalling and Mass Spectrometry Matthias Selbach 54 Cardiovascular Molecular Genetics Ludwig Thierfelder II MDC Research Report 2014 TABLE OF CONTENTS Table of Contents Inhalt 58 Molecular Epidemiology Tobias Pischon 62 microRNA and Molecular Mechanisms of Metabolic Diseases Matthew N. Poy 64 Genetics of Metabolic and Reproductive Disorders Mathias Treier 69 Cancer Research Coordinator: Claus Scheidereit 72 Computational Biology and Data Mining Miguel Andrade 74 Signal Transduction in Development and Cancer Walter Birchmeier 78 Molecular Immunology and Gene Therapy Thomas Blankenstein 82 Clinical and Molecular Oncology Peter Daniel 84 Structure and Function of Membrane-associated GTPases Oliver Daumke 88 Haematoloy, Oncology and Tumorimmunology Bernd Dörken 92 Experimental Pharmacology Iduna Fichtner 96 Macromolecular Structure and Interaction Udo Heinemann 100 Cell Differentiation and Tumorigenesis Achim Leutz 104 Molecular Tumor Genetics and Immunogenetics Martin Lipp 108 Molecular Immunotherapy Antonio Pezzutto 110 Immune Regulation and Cancer Klaus Rajewsky 114 Spatio-temporal Control of Rho GTPase Signaling Oliver Rocks 116 Signal Transduction in Tumor Cells Claus Scheidereit 120 Cancer Genetics and Cellular Stress Responses Clemens A. Schmitt 122 Stem Cell and Macrophage Biology Michael Sieweke 124 Intracellular Proteolysis Thomas Sommer 128 Molecular Cell Biology and Gene Therapy Wolfgang Uckert MDC Research Report 2014 III TABLE OF CONTENTS 131 Diseases of the Nervous System Coordinator: Carmen Birchmeier 134 Developmental Biology / Signal Transduction Carmen Birchmeier 138 Physiology and Pathology of Ion Transport Thomas J. Jentsch 142 Developmental Neurobiology Fritz G. Rathjen 146 Molecular Physiology of Somatic Sensation Gary Lewin 150 RNA Editing and Hyperexcitability Disorders Jochen Meier 152 Signaling and Transport Processes Björn Christian Schroeder 154 Neural Circuits and Behaviour James Poulet 156 Cellular Neurosciences Helmut Kettenmann 160 Proteomics and Molecular Mechanisms of Neurodegenerative Diseases Erich Wanker 164 Molecular Pathways in Cortical Development Annette Hammes 166 Cellular Sensing of the Physical Environment Kathryn Poole 169 Berlin Institute for Medical Systems Biology Coordinator: Nikolaus Rajewsky 172 Non-coding RNAs and Mechanisms of Cytoplasmic Gene Regulation Marina Chekulaeva 174 Novel Sequencing Technology, Functional and Medical Genomics Wei Chen 176 Metabolic Regulation Stefan Kempa 178 RNA Biology and Posttranscriptional Regulation Markus Landthaler 180 Signaling Dynamics in Single Cells Alexander Loewer 182 Evolutionary Modeling and Inference in Computational Systems Biology Benedikt Obermayer 184 Computational Regulatory Genomics Uwe Ohler 188 Epigenetic Regulation and Chromatin Architecture Ana Pombo IV MDC Research Report 2014 TABLE OF CONTENTS 192 Systems Biology of Gene Regulatory Elements Nikolaus Rajewsky 196 Gene Regulation and Cell Fate Decision in C. elegans Baris Tursun 198 Systems Biology of Neural Tissue Differentiation Robert P. Zinzen 201 The Experimental and Clinical Research Center (ECRC) Coordinator: Friedrich C. Luft 206 Muscle Research Unit and Outpatient Clinic for Muscle Disorders of the Charité Simone Spuler 208 Nephrology and Inflammatory Vascular Diseases Ralph Kettritz 210 Cardiac MRI Jeanette Schulz-Menger 212 Registry Diabetic Nephropathy / Blood Vessel Function and Target-Organ Damage Maik Gollasch 214 Cardiovascular Genetics Silke Rickert-Sperling 216 Endocrinology, Diabetes and Nutritional Medicine Joachim Spranger 218 Hypertension-induced Target Organ Damage Dominik N. Müller, Ralf Dechend 220 Translational Oncology of Solid Tumors Ulrike Stein 223 Technology Platforms 226 Advanced Light Microscopy Anje Sporbert 228 BIMSB Bioinformatics Altuna Akalin 230 BIMSB Genomics Wei Chen 232 BIMSB Proteomics & Metabolomics Stefan Kempa 234 Electron Microscopy Bettina Purfürst 236 Interactomics Erich Wanker 238 Magnetic Resonance (Berlin Ultrahigh Field Facility, B.U.F.F.) Thoralf Niendorf MDC Research Report 2014 V TABLE OF CONTENTS 240 Mass Spectrometry Gunnar Dittmar 242 Pathophysiology Arnd Heuser 244 Preparative Flow Cytometry Hans-Peter Rahn 246 Transgenics Ralf Kühn 249 Technology Transfer 252 Enabling Technologies for Drug Discovery in Alzheimer’s and Further Protein Misfolding Diseases Annett Böddrich 252 Development of inhibitors of intracellular protein-protein interactions for the treatment of heart failure Adeeb Eldahshan 253 Exploitation of novel transduction targets for pain relief Christiane Wetzel and Gary R. Lewin 253 Development of novel compounds that inhibit growth of prostate cancer cells David Miles Carter 254 Alternative Splicing as a Therapeutic Target for Cardiac Disease Michael Radke 257 Academics Akademische Aktivitäten 258 International PhD Program Internationales Doktorandenprogramm 261 MDC Postdoctoral Program 262 MDC International 264 Appointments Berufungen 268 Awards Preise 269 European Research Council (ERC) Grants 270 Third-party Funding 2012-2013 Drittmittelprojekte 272 Conferences and Scientific Meetings Kongresse und wissenschaftliche Tagungen 274 Seminars 2012-2013 VI MDC Research Report 2014 TABLE OF CONTENTS 281 Annex Anhang 282 Helmholtz Association Helmholtz-Gemeinschaft 286 Berlin Institute of Health (BIH) Berliner Institut für Gesundheitsforschung 290 German Centre for Cardiovascular Research Deutsches Zentrum für Herz-Kreislauf-Forschung 291 EU-Life 292 Biotechnology Park with Innovation and Founding Center Biotechnologiepark mit Innovations- und Gründerzentrum 296 Health Care Industry Cluster Cluster Gesundheitswirtschaft 298 Press Department Pressestelle 300 Communications Department Kommunikationsabteilung 302 Organization Chart Organigramm 304 Organizational Structure Organisationsstruktur 310 Publications 312 Facts and Figures Kennzahlen 316 Index 327 Campus Map MDC Research Report 2014 VII Introduction by the Scientific Director Vorwort des Wissenschaftlichen Vorstands his research report looks back to two ieser Forschungsbericht blickt auf zwei eventful years at the Max Delbrück Cen- ereignisreiche Jahre am Max-Delbrück- Tter. We have not only launched the Berlin DCentrum zurück. So haben wir nicht nur Institute of Health, but also have co-founded das Berliner Institut für Gesundheitsforschung/ the German Centre for Cardiovascular Research Berlin Institute of Health auf den Weg gebracht, (DZHK). In 2012, we celebrated our 20-year sondern auch das Deutsche Zentrum für Herz- anniversary and we have set the course for the Kreislauf-Forschung mitgegründet. Wir haben site in the heart of Berlin. wir haben die Weichen dafür gestellt, dass das MDC to open for the first time a second major MDC2012 erstmalsunser 20-jähriges einen zweiten Bestehen großen gefeiert Standort und im Herzen Berlins eröffnen wird. changes in many respects. In the coming two years,With all laws this, will the come MDC into looks effect ahead that willto major regu- Das MDC steht damit in vielerlei Hinsicht vor late the establishment of the Berlin Institute großen Veränderungen. In den kommenden of Health as a new public body and which thus beiden Jahren werden Gesetze auf den Weg will regulate also the future of our center. The gebracht, die die Gründung des Berliner Insti- MDC and the Charité – Universitätsmedizin tuts für Gesundheitsforschung als neue Körper- Berlin will both become member institutions schaft des öffentlichen Rechts und damit auch of the Berlin Institute of Health (BIH). This die Zukunft unseres Zentrums regeln. Das MDC way, we will institutionalize our partnership und die Charité – Universitätsmedizin Berlin with the Charité that we have been maintain- - ing since our founding in 1992. At the same lin Institute of Health (BIH) werden. Auf diese time, both parts of the new institute will main- Wwerdeneise institutionalisieren jeweils Gliedkörperschaften wir die seit des unserer Ber tain their respective identities and their very Gründung 1992 bestehende Partnerschaft mit own range of tasks. In the case of the MDC, der Charité. Beide Teile des neuen Instituts these tasks are biomedical basic research and disease-oriented research that is embedded ihre ureigenen Aufgaben behalten. Im Falle into the strategic research
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