DOCSLIB.ORG

Shizuka Uchida, Ph.D. Associate Professor of Medicine

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Shizuka Uchida, Ph.D. Associate Professor of Medicine Shizuka Uchida, Ph.D. Associate Professor of Medicine Cardiovascular Innovation Institute University of Louisville 302 E Muhammad Ali Blvd Louisville, KY 40202, United States Phone: 502-854-0570 Fax: 502-852-7195 E-mail: [email protected] EDUCATION 05/98 B.S. in Biology (cum laude), Creighton University, Omaha, Nebraska 09/03 M.S. in Bioinformatics, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan 03/07 Ph.D. in Molecular Biology, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan ACADEMIC APPOINTMENTS 08/16 – pres. Associate Professor of Medicine Cardiovascular Innovative Institute University of Louisville Louisville, Kentucky U.S.A. 08/12 – 12/16 Independent Junior Group Leader (equivalent to Assistant Professor) Institute of Cardiovascular Regeneration Centre for Molecular Medicine Goethe University Frankfurt Frankfurt am Main Germany OTHER POSITIONS AND EMPLOYMENT 08/96 – 05/97 Resident Advisor, Creighton University, Omaha, Nebraska 06/98 – 08/01 General Manager, Tsukasa, Inc., Hiroshima, Hiroshima, Japan 04/04 – 03/06 Bioinformatics Engineer, World Fusion Co., Ltd., Ningyo-cho, Tokyo, Japan 04/06 – 03/10 Post Doctoral Fellow, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany 04/10 – 07/12 Group Leader, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany PROFESSIONAL MEMBERSHIPS AND ACTIVITIES 04/04 – 03/06 Member, Molecular Biology Society of Japan 04/04 – 03/06 Member, Japanese Society for Bioinformatics 10/15 – pres. Member, International Society for Computational Biology 08/16 – pres. Member, American Heart Association Editorial Boards 03/17 – pres. Review Editor for Frontiers in Cardiovascular Medicine Shizuka Uchida, 04/17/2018 Page 2 of 18 Manuscript Peer Review Ad hoc Reviewer: 3Biotech, Aging, American Journal of Physiology-Cell Physiology, American Journal of Physiology-Heart and Circulatory Physiology, Antioxidants and Redox Signaling, Atherosclerosis, Bioinformatics, Biomedicine & Pharmacotherapy, BMC Developmental Biology, BMC Bioinformatics, Briefings in Bioinformatics, Cell Biology International, Cellular Physiology and Biochemistry, Cells, Circulation Research, Current Bioinformatics, Database, EMBO Molecular Medicine, European Heart Journal, FEBS Journal, FEBS Open Bio, Frontiers in Cardiovascular Medicine, Frontiers in Genetics, Frontiers in Neuroscience, Frontiers in Physiology, Gene, Gene Expression Patterns, Genes, Genome Biology, International Journal of Molecular Sciences, International Journal of Developmental Neuroscience, Journal of Clinical Investigation, JCI Insight, Journal of Clinical Medicine, Journal of Molecular and Cellular Cardiology, Journal of Cell Biology, Journal of Cellular Biochemistry, Mechanisms of Development, Mediators of Inflammation, Molecular Genetics and Genomics, Nucleic Acids Research, Nature Reviews Genetics, Non-Coding RNA, Oncotarget, Physiological Genomics, PLoS ONE, Scientific Journal of Musculoskeletal Disorders, Scientific Reports, Tumor Biology Grant Peer Review 09/15 Research grant application from the German Research Foundation (DFG), Germany 02/16 Research grant application from the German Research Foundation (DFG), Germany 12/16 Research grant application from the German Research Foundation (DFG), Germany 10/17 Research grant application from the German Research Foundation (DFG), Germany 10/17 Research grant application from the Netherlands Organisation for Scientific Research (NWO), Netherlands 11/17 Research grant applications from the National Center of Science and Technology Evaluation (JSC), Kazakhstan 01/18 Fellowship program applications (GTOE Clinical committee) from the American Heart Association (AHA) HONORS AND AWARDS 08/94 – 05/98 Lynn Scholarship, Creighton University, Omaha, Nebraska 08/03 – 12/03 Grosscurth Scholarship/University Fellowship, University of Louisville, Louisville, Kentucky 04/04 – 03/07 Tuition Fee Exemption Award for Excellent Students, Japan Advanced Institute of Science and Technology, Ishikawa, Japan 04/06 – 03/07 Foreign Study Grant, Mochida Memorial Foundation for Medical and Pharmaceutical Research, Tokyo, Japan 04/06 – 03/08 Research Fellowship for Young Scientists (DC2), Japan Society for the Promotion of Science, Tokyo, Japan (Declined for studying abroad at the Max Planck Institute for Heart and Lung Research) 03/06 – 03/08 Scholarship Program for College and Graduate Students Studying Abroad, Yoshida Scholarship Foundation, Tokyo, Japan 06/2011 Poster award, 2nd International Symposium of the Excellence Cluster Cardio Pulmonary System (ECCPS) (June 16- 18, 2011), Bad Nauheim, Germany 11/2015 Most downloaded review article from Circulation Research, AHA Scientific Sessions 2015 (November 10, 2015), Orlando, Florida EDUCATIONAL ACTIVITIES To Graduate Students 04/04 – 03/06 Teaching Assistant for molecular biology courses, Japan Advanced Institute of Science and Technology, Ishikawa, Japan 04/04 – 03/06 English Instructor, Japan Advanced Institute of Science and Technology, Ishikawa, Japan 04/08 – 07/12 Thesis/Dissertation Mentor for two diploma students in bioinformatics and six PhD students in developmental biology, cell biology, genetics and molecular biology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany Shizuka Uchida, 04/17/2018 Page 3 of 18 08/12 – pres. Thesis/Dissertation Mentor for one bachelor student and one master student in bioinformatics and five PhD students in bioinformatics and cardiovascular biology, Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany 11/14 Instructor, Moderne Methoden (Vorlesung und Seminar—Next Generation Sequencing), Molecular Medicine Master of Science program, Goethe University Frankfurt, Frankfurt am Main, Germany 11/14 Instructor, Frankfurter Forschung (Vorlesung und Seminar), Molecular Medicine Master of Science program, Goethe University Frankfurt, Frankfurt am Main, Germany 10/15 Instructor, Moderne Methoden (Vorlesung und Seminar—Next Generation Sequencing), Molecular Medicine Master of Science program, Goethe University Frankfurt, Frankfurt am Main, Germany 11/15 Instructor, Frankfurter Forschung (Vorlesung und Seminar), Molecular Medicine Master of Science program, Goethe University Frankfurt, Frankfurt am Main, Germany To Professionals 03/14 Instructor, SFB834 Workshop for Bioinformatics (bioinformatics analysis of microarrays and next generation sequencing data) 02/15 Instructor, SFB834 Workshop for Bioinformatics (bioinformatics analysis of microarrays and next generation sequencing data) 11/15 Instructor, SFB834 Workshop for Bioinformatics (Understanding the set of interesting genes that you identified via DAVID and NetworkAnalyst) 12/15 Instructor, SFB834 Workshop for Bioinformatics (Making a heatmap and performing clustering via MeV) GRANTS AND CONTRACTS Research Grants Current 1. 04/18 – 03/23 Co-Investigator, “The Role of Cariomyogenic Lineage Commitment in Cardiac Mesenchymal Cell- Mediated Extracellular Vesicle Signaling and Cardiac Repair, NIH-NHLBI, R01 HL141081 (PI: Moore) Direct Cost: $42,473 2. 09/17 – 08/22 Co-Investigator, “Protection of ischemic myocardium”, NIH-NHLBI, P01 HL078825 (PI: Bolli) Direct Cost: $33,469 3. 01/17 – 12/21 Co-PI, “Gibbs Lung Research Program”, GSG III Foundation, Louisville Direct Cost: $1,050,000 Past 1. 03/06 – 03/08 PI, “Elucidating the cardiomyocyte differentiation mechanisms of adult stem cells and their applications”, Yoshida Scholarship Foundation (Tokyo, Japan) Direct Cost: ¥2,500,000 2. 01/08 – 12/09 Co-PI with Dr. Tibor Ziegelhöffer (Kerckhoff-Klinik, Bad Nauheim, Germany), “Searching for Heart Failure Biomarkers: systems biology approach”, Kerckhoff Foundation (Bad Nauheim, Germany) Direct Cost: €21,000 3. 01/10 – 12/11 PI, “Characterization and induction of cardiac stem cells into functional cardiomyocytes”, Shizuka Uchida, 04/17/2018 Page 4 of 18 Excellence Cluster Cardio-Pulmonary System (Gießen, Germany) Direct Cost: €80,000 4. 01/11 – 12/12 PI, “Elucidation of stemness and differentiation of adult stem cells”, LOEWE Center for Cell and Gene Therapy (State of Hessen, Germany) Direct Cost: €40,000 5. 01/12 – 12/13 Project Scientist, “The fates of bronchioalveolar stem cells (BASCs) and other putative lung adult stem cells using cellular lineage tracing”, Universities of Giessen and Marburg Lung Center (UGMLC)(State of Hessen, Germany) Direct Cost: €100,000 6. 01/12 – 12/13 PI, “Uncovering the heterogeneity of Sca1-positive adult stem cells during the ageing process”, LOEWE Center for Cell and Gene Therapy (State of Hessen, Germany) Direct Cost: €80,000 7. 01/13 – 12/13 Co-PI with Prof. Stefanie Dimmeler (Goethe University Frankfurt, Frankfurt am Main, Germany) and Prof. Edgar Wingender (University of Göttingen, Göttingen, Germany), “Integration of comprehensive transcriptomes to decipher processes controlling cardiogenesis”, German Centre for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf- Forschung e. V. (DZHK))(Partner side Rhein-Main, Germany) Direct Cost: €35,700 8. 01/14 – 12/14 Co-PI with Prof. Edgar Wingender and Prof. Wolfram-Hubertus Zimmermann (University of Göttingen, Göttingen, Germany), “Elucidating the interactions among genes and noncoding RNAs controlling cardiogenesis”, German Centre for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung e. V. (DZHK))(Partner side Rhein-Main, Germany), Direct Cost: €20,000 9. 01/13 – 12/13 Co-PI with Prof. Edgar Wingender and
Load more

Recommended publications
  • Press Release
    Press Release No. 30/December 14, 2011 Press2011_Leibniz-Prize_Nikolaus_Rajewsky Nikolaus Rajewsky of the MDC to Receive the Leibniz Prize – the Highest Honor Awarded in German Research Professor Nikolaus Rajewsky of the Max Delbrück Center for Molecular Medicine (MDC) Berlin is to receive Germany’s most prestigious research award, the Gottfried Wilhelm Leibniz Prize. The announcement was made by the German Research Foundation (DFG) on Thursday, December 8, 2011. This is the second time the prize will go to the MDC. In 2002 Professor Carmen Birchmeier received the award. In 2012 the prize will be awarded to a total of eleven scientists: two women and nine men were selected from among 131 nominations. The Leibniz Prizes, each endowed with up to 2.5 million euros, will be presented in an award ceremony in Berlin on February 27, 2012. Nikolaus Rajewsky is Professor of Systems Biology at the MDC and the Charité and Scientific Director of the “Berlin Institute for Medical Systems Biology” (BIMSB) at the MDC. Systems biology combines molecular biology, biochemistry, mathematics and physics in order to quantitatively capture and predict complex processes of life. Professor Rajewsky’s research activities focus mainly on microRNAs, a group of genes discovered only a few years ago. As Nikolaus Rajewsky has demonstrated experimentally and with the aid of bioinformatics, microRNAs play an important role in the regulation of genes, including those that play a crucial role in the development of diseases. This discovery opens up a huge field of potential applications, including target structures for novel therapy approaches. In addition, Professor Rajewsky and his group have also made important methodological and technological advances.
    [Show full text]
  • German Immunologist Receives Ernst Schering Prize
    PRESSEINFORMATION Retired in Germany, successful at Harvard: German immunologist receives Ernst Schering Prize Klaus Rajewsky receives the Ernst Schering Prize 2008 for his outstanding research in the area of analysis, development, activation and differentiation of B-lymphocytes. Berlin, 7th of October 2008 Today Professor Klaus Rajewsky from the Immune Disease Institute of Harvard Medical School, Boston, USA receives the Ernst Schering Prize 2008 for his pioneering work in the area of B-cell-biology. With his research he has significantly contributed to our understanding of B-lymphocytes as well as the development of certain lymphatic cancers, the so called lymphomas. Since his discovery that B-cells from germinal centres are the tumour cells of Hodgkin’s Lymphoma, Rajewksy and his team have been working on reconstructing the pathogenic course of the disease in a mouse model. Using the technology of conditional gene targeting, which was developed by Rajewsky, they aim to reveal the genetic background of the disease. The 50.000 Euro Ernst Schering Prize will be awarded to the laureate during a ceremony in Berlin. By awarding the Ernst Schering Prize to Klaus Rajewsky the Schering Foundation wishes to draw attention to the loss of outstanding German researchers due to strict retirement regulations in the German academic system. Rajewsky, who was forced to retire as an active researcher after almost thirty years at the University of Cologne, took up professorship at the University of Harvard, where he still heads a successful and productive research group. “The German retirement regulations would have resulted in shaky financial conditions for my group in Cologne”, Rajewsky recalls.
    [Show full text]
  • Genetic Determinants of the Development and Evolution of Drosophila Pigmentation
    Genetic Determinants of the Development and Evolution of Drosophila Pigmentation By Abigail M. Lamb A disseratation submitted in partial fulfillment Of the requirements for the degree of Doctor of Philosophy (Molecular, Cellular, and Developmental Biology) In the University of Michigan 2021 Doctoral Committee: Professor Patricia Wittkopp, Chair Associate Professor Scott Barolo Associate Professor Laura Buttitta Professor Kenneth Cadigan Abigail M. Lamb [email protected] ORCID iD: 0000-0001-5184-4180 Dedication To everyone who started graduate school but, for any reason, didn’t continue to the point of dissertation defense. I was lucky to have the support I had, otherwise I would not have made it to this point. I have seen too many wonderful, talented people pushed out of academic science, and they deserved so much better than what they experienced. ii Acknowledgments I would first like to thank Trisha Wittkopp, not only for her scientific and professional mentorship, but especially for her support, kindness, and understanding during (possibly too many) years of struggle and success – both at the bench and in life. Going to college in the first place felt like a stretch goal given the circumstances of my early life, and graduate school even now somehow sounds impossibly unlikely, even as I complete my dissertation. I truly believe that my ability to succeed in graduate school was dependent on finding an environment and culture where I could thrive, and the Wittkopp Lab became Home to an extent that is difficult to describe. For fear of forgetting someone, I will not attempt to individually name all of the many, many labmates I spent time with both in and out of the lab.
    [Show full text]
  • MDC-NYU Phd Exchange Program in Medical Systems Biology
    MDC-NYU PhD Exchange Program in Medical Systems Biology Basic information Keywords: Medical Systems Biology │ Computational Biology │ Mathematical Modeling│ Developmental Biology │ RNA Biology │ Gene Regulation │ -Omics Technologies │ Imaging Technologies Program director(s): Prof.Nikolaus Rajewsky (Berlin) and Prof. Stephen J. Small (New York) Program coordinators: Dr Jutta Steinkötter (management) and Dr Grietje Krabbe (administration). Enquiries to [email protected] Program weblink: www.mdc-berlin.de/bimsb Detailed program information Program summary description: The Berlin Institute for Medical Systems Biology offers an exceptional PhD Exchange Program to support interdisciplinary research projects and international PhD education. PhD topics are structured as collaborative projects between the Center for Genomics and Systems Biology at New York University and the Berlin Institute for Medical Systems Biology at the MDC. A Principal Investigator from each institution supervises each student, students who are expected to divide their time between Berlin and New York, taking advantage of complimentary research and training expertise. Resources are available for travel from Berlin to New York for short and long term working periods as well as for course and conference participation. The regular guidance of an international PhD Committee supports the creation of individual research and training portfolios. Systems medicine and/or translational highlights: extensive bioinformatics; training in and access to BIMSB and BIH state of the art genomic, transcriptomic, proteomic and metabolomics technologies; major national and international collaborations e.g. Charité and MRC Clinical Sciences Center London. Primary funding source: Helmholtz Association Program start date: 02/2009 Number of students recruited per year (estimated): 2-3 Number of program funded positions/places (excluding third party funding): up to 10 Duration of program: 3-4 years Scientific training Lecture series: Each semester Systems Biology Lectures tackle a new topic in the field.
    [Show full text]
  • Computational Identification of Microrna Targets Nikolaus Rajewsky* and Nicholas D Socci†‡
    This information has not been peer-reviewed. Responsibility for the findings rests solely with the author(s). comment Deposited research article Computational identification of microRNA targets Nikolaus Rajewsky* and Nicholas D Socci†‡ Addresses: * Department of Biology, New York University 1009 Main Building, 100 Washington Square East, New York, NY 10003-6688, reviews USA. †Department of Pathology, and Seaver Foundation for Bioinformatics, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA. ‡Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. Correspondence: Nikolaus Rajewsky. E-mail: [email protected] Posted: 14 January 2004 Received: 12 January 2004 Genome Biology 2004, 5:P5 reports The electronic version of this article is the complete one and can be This is the first version of this article to be made available publicly, and no found online at http://genomebiology.com/2004/5/2/P5 other version is available at present. © 2004 BioMed Central Ltd deposited research refereed research .deposited research AS A SERVICE TO THE RESEARCH COMMUNITY, GENOME BIOLOGY PROVIDES A 'PREPRINT' DEPOSITORY TO WHICH ANY ORIGINAL RESEARCH CAN BE SUBMITTED AND WHICH ALL INDIVIDUALS CAN ACCESS interactions FREE OF CHARGE. ANY ARTICLE CAN BE SUBMITTED BY AUTHORS, WHO HAVE SOLE RESPONSIBILITY FOR THE ARTICLE'S CONTENT. THE ONLY SCREENING IS TO ENSURE RELEVANCE OF THE PREPRINT TO GENOME BIOLOGY'S SCOPE AND TO AVOID ABUSIVE, LIBELLOUS OR INDECENT ARTICLES. ARTICLES IN THIS SECTION OF THE JOURNAL HAVE NOT BEEN PEER-REVIEWED. EACH PREPRINT HAS A PERMANENT URL, BY WHICH IT CAN BE CITED. RESEARCH SUBMITTED TO THE PREPRINT DEPOSITORY MAY BE SIMULTANEOUSLY OR SUBSEQUENTLY SUBMITTED TO information GENOME BIOLOGY OR ANY OTHER PUBLICATION FOR PEER REVIEW; THE ONLY REQUIREMENT IS AN EXPLICIT CITATION OF, AND LINK TO, THE PREPRINT IN ANY VERSION OF THE ARTICLE THAT IS EVENTUALLY PUBLISHED.
    [Show full text]
  • STOA Workshop Breakfast Artificial Intelligence for Early Diagnosis and Treatment Participants’ Booklet
    STOA workshop breakfast Artificial intelligence for early diagnosis and treatment Participants’ booklet EPRS | European Parliamentary Research Service Scientific Foresight Unit (STOA) PE 624.295 – February 2019 ARTIFICIAL INTELLIGENCE FOR EARLY DIAGNOSIS AND TREATMENT 07 February 2019, 8:00-9:00 Altiero Spinelli building, room 7F387 European Parliament, Brussels 1 Prepared by Gianluca Quaglio, STOA Secretariat. Available at: http://www.europarl.europa.eu/stoa/en/events/20181002WKS01941/innovative-solutions- for-research-in-hea 2 Table of Contents 1. Programme __________________________________________________________________ 4 2. Introduction _________________________________________________________________ 5 3. About LifeTime_______________________________________________________________ 7 4. Welcome ____________________________________________________________________ 8 4.1. Paul RÜBIG, MEP and STOA First Vice-Chair ______________________________________ 8 5. Speakers ____________________________________________________________________ 9 5.1. Wolfgang BURTSCHER, DG Research, European Commission ________________________ 9 5.2. Amos TANAY, Weizmann Institute, Rehovot, Israel _______________________________ 10 5.3. Marc A. MARTI-RENOM, Catalan Institution for Research and Advanced Studies and National Center for Genomic Analysis, Barcelona, Spain. _____________________________________ 11 5.4. Angelika EGGERT, Charité-Universitätsmedizin Berlin._____________________________ 12 5.5. Nikolaus RAJEWSKY, Max Delbrück Center for Molecular Medicine
    [Show full text]
  • CV Nikolaus Rajewsky
    Curriculum Vitae Prof. Dr. Nikolaus Rajewsky Name: Nikolaus Rajewsky Geboren: 1968 Foto: David Ausserhofer/MDC Forschungsschwerpunkte: Genregulation, RNA-Biologie, Einzellzell-Analyse, molekulare Mechanismen der Krankheitsentstehung Nikolaus Rajewsky ist Systembiologe. Schwerpunkt seiner Forschung ist die Einzelzell-Analyse. Er möchte verstehen, was in den menschlichen Zellen während einer Erkrankung geschieht, um schon die ersten Veränderungen in der Zelle zu erkennen und gezielt zu behandeln. Ziel ist eine maßgeschneiderte Medizin. Für seine Forschung entwickelt er neue Computerprogramme und Analysemethoden. Akademischer und beruflicher Werdegang seit 2008 (Gründungs-)Direktor des „Berlin Institute for Medical Systems Biology“ (BIMSB) seit 2006 Professor am Max-Delbrück-Centrum für Molekulare Medizin (MDC) in der Helmholtz-Gemeinschaft 2003 - 2006 Assistenzprofessur, Department of Biology und Courant Institute for Mathematical Sciences, New York University, New York City, USA 1999 - 2002 Postdoc für Computerbiologie, Rockefeller University, New York City, USA 1998 Postdoc für mathematische statistische Physik, Rutgers, The State University of New Jersey, USA 1997 Promotion in Theoretischer Physik, Universität zu Köln 1996 Künstlerische Reifeprüfung, Folkwang Universität der Künste, Essen 1995 Diplom in Theoretischer Physik, Universität zu Köln 1991 - 1996 Studium Klavier, Folkwang Universität der Künste, Essen 1988 - 1995 Studium Mathematik und Theoretische Physik, Universität zu Köln Nationale Akademie der Wissenschaften Leopoldina
    [Show full text]
  • Top Authors in Simulation - Microsoft …
    26/09/2010 Top authors in Simulation - Microsoft … Advanced Search Top authors in Simulation Filter: Simulation All Years Author In Domain Author Publication Citations Conference Richard M. Fujimoto Georgia Institute of Technology Journal 1 Publications: 210 | Citations: 3939 | G-Index: 56 | H-Index: 29 1578 Organization Averill M. Law 2 Publications: 102 | Citations: 2657 | G-Index: 51 | H-Index: 17 942 W. David Kelton University of Cincinnati 3 Publications: 86 | Citations: 2605 | G-Index: 50 | H-Index: 15 896 Barry L. Nelson Purdue University 4 Publications: 158 | Citations: 1772 | G-Index: 38 | H-Index: 20 852 Bernard Zeigler University of Arizona 5 Publications: 200 | Citations: 2401 | G-Index: 45 | H-Index: 18 792 David M. Nicol University of Illinois Urbana Champaign 6 Publications: 229 | Citations: 2706 | G-Index: 43 | H-Index: 25 697 David R. Jefferson University of California Los Angeles 7 Publications: 54 | Citations: 2024 | G-Index: 44 | H-Index: 22 681 Philip Heidelberger IBM 8 Publications: 116 | Citations: 2201 | G-Index: 43 | H-Index: 25 603 James R. Wilson Rochester Institute of Technology 9 Publications: 194 | Citations: 1113 | G-Index: 24 | H-Index: 18 586 Lee W. Schruben University of California Berkeley 10 Publications: 102 | Citations: 862 | G-Index: 25 | H-Index: 16 544 Peter W. Glynn Publications: 183 | Citations: 2291 | G-Index: 41 | H-Index: 23 11 527 Stanford University Robert Sargent Publications: 101 | Citations: 1136 | G-Index: 30 | H-Index: 19 12 521 Syracuse University …microsoft.com/…/author_category_2… 1/35 26/09/2010 Top authors in Simulation - Microsoft … Osman Balci Publications: 78 | Citations: 782 | G-Index: 23 | H-Index: 16 13 454 Virginia Polytechnic Institute and State University Jayadev Misra Publications: 136 | Citations: 3325 | G-Index: 56 | H-Index: 26 14 453 University of Texas Austin Rajive Bagrodia Publications: 175 | Citations: 3160 | G-Index: 51 | H-Index: 24 15 435 University of California Los Angeles Richard E.
    [Show full text]
  • Microrna Target Predictions Across Seven Drosophila Species and Comparison to Mammalian Targets
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by PubMed Central microRNA Target Predictions across Seven Drosophila Species and Comparison to Mammalian Targets Dominic Gru¨ n, Yi-Lu Wang, David Langenberger, Kristin C. Gunsalus, Nikolaus Rajewsky* Center for Comparative Functional Genomics, Department of Biology, New York University, New York, New York, United States of America microRNAs are small noncoding genes that regulate the protein production of genes by binding to partially complementary sites in the mRNAs of targeted genes. Here, using our algorithm PicTar, we exploit cross-species comparisons to predict, on average, 54 targeted genes per microRNA above noise in Drosophila melanogaster. Analysis of the functional annotation of target genes furthermore suggests specific biological functions for many microRNAs. We also predict combinatorial targets for clustered microRNAs and find that some clustered microRNAs are likely to coordinately regulate target genes. Furthermore, we compare microRNA regulation between insects and vertebrates. We find that the widespread extent of gene regulation by microRNAs is comparable between flies and mammals but that certain microRNAs may function in clade-specific modes of gene regulation. One of these microRNAs (miR-210) is predicted to contribute to the regulation of fly oogenesis. We also list specific regulatory relationships that appear to be conserved between flies and mammals. Our findings provide the most extensive microRNA target predictions in Drosophila to date, suggest specific functional roles for most microRNAs, indicate the existence of coordinate gene regulation executed by clustered microRNAs, and shed light on the evolution of microRNA function across large evolutionary distances.
    [Show full text]
  • Nikolaus Rajewsky Max Delbrück Center for Molecular Medicine (MDC) Berlin Institute for Medical Systems Biology (BIMSB) Robert-Rössle-Str
    Nikolaus Rajewsky Max Delbrück Center for Molecular Medicine (MDC) Berlin Institute for Medical Systems Biology (BIMSB) Robert-Rössle-Str. 10 D-13125 Berlin Phone: +49 (0)30 94062999 Email: rajewsky(at)mdc-berlin.de Curriculum vitae Since 2008 Scientific Director, BIMSB, MDC, Berlin Since 2006 Full professor (W3) for Systems Biology, Charité (MDC), Berlin 2003 – 2006 Assistant professor, Department of Biology and Courant Institute for Mathematical Sciences, New York University (tenure track) 1999 – 2002 Postdoctoral fellow, The Rockefeller University, New York, US 1998 – 1999 Postdoctoral fellow, Rutgers University, New Brunswick, US 1995 – 1997 PhD in Theoretical Physics, Universität zu Köln 1994 – 1995 Diploma in Theoretical Physics, Universität zu Köln Research fields Our group combines theoretical/computational and experimental methods to understand gene regulation in animals with major focus on: § Post-transcriptional gene regulation by small RNAs (for example microRNAs) and RNA binding proteins § Interdisciplinary approaches employing techniques from molecular biology and biochemistry on different model organisms § Analysis with tools and concepts from bioinformatics, statistics, and physics Activities in the scientific community, honors, awards 2017 Coordinator, Marie Skłodowska-Curie Innovative Training Networks, European Commission (3.5 million Euros) 2016, 2017 Visiting professor for research activities, Sapienza – University of Rome, IT 2014 Honorary PhD in Human Genetics and Medical Biology, Sapienza – University of Rome,
    [Show full text]
  • Systems Biology at the Max Delbrück Center for Molecular Medicine Berlin-Buch
    NEW BUILDING IN THE PHD PROGRAM, SYSTEMS BIOLOGY CENTER OF BERLIN PARTNERS & ACTIVITIES AT THE MDC The Berlin Institute for Medical Systems Biology at the Max Delbrück Center for Molecular Medicine Berlin-Buch For further information contact Grietje Krabbe: [email protected] Every Wednesday, From 09:30 to 10:30 AM MDC.C Conference Center, Dendrite 2/3 Robert-Rössle-Str. 10, 13125 Berlin COMPUTATIONAL FRIDAY 06 FEBRUARY AT 12 NOON DENDRIT 2-3 A HANDS-ON COURSE ON GENOMICS DATA ANALYSIS Student Seminar Systems Biology in Systems Biology Lectures Every second Proteins & Proteomics Friday systems Friday 05 SeptemBer at 12 noon dendrit 2-3 biology students Date Speaker Topics LECTURERS / INSTRUCTORS I Berlin present their Djordje 28 October 2015 Matthias Selbach, MDC Shotgun proteomics: an introduction 18-24 OCT 2015 FRIDAY 10 APRIL 12 NOON DENDRIT 2-3 ALTUNA AKALIN work in Vasiljevic Proteome meets genome: dynamics of chromatin 8 Berlin Summer Meeting Germany I Berlin Institute Jeroen Krijgsveldt, EMBL progress. (Selbach lab) 04 November 2015 composition in embryonic stem cells Max Delbrück Center, Berlin Institute for Medical Systems Biology for Medical Systems Biology, 11 November 2015 Oliver Daumke, MDC Structure-function studies in dynamin superfamily proteins For further information contact Jennifer Stewart: [email protected] Bioinformatic Analysis of Proteomic Data using Max Delbrück Center Student Seminar in Stefanie 18 November 2015 Knut Reinert, FU Berlin RICHARD BONNEAU OpenMS and KNIME New York University, Seelk Every Wednesday, from 09:30 to 10:30 AM 25 November 2015 Mathias Dreger, Caprotech Capture Compound Mass Spectrometry:Student A Chemoproteo- Seminar in New York, USA Application Deadline (Tursun lab) mic approach to profile small molecule-protein interactions 30 July 2015 Systems Biology MDC.C Conference Center, MDC Berlin-Buch 02 December 2015 Marcus Bantscheff, Cellzome Drug action in the context of the proteome UWE OHLER Cell-type specific Max Delbrück Center, Robert-Rössle-Str.
    [Show full text]
  • 13.4 Jobs Career View MH
    CAREER VIEW NATURE|Vol 440|13 April 2006 MOVERS SCIENTISTS & SOCIETIES Nikolaus Rajewsky, head of bioinformatics Mass uprising of women in science research, Max Delbrück Center, Berlin, Germany How do you revive a dormant chapter promoting the advancement of women. of a national organization? The Boston We are currently trying to organize 2003–06: Assistant professor, chapter of the Association of Women in a series of leadership workshops for Center for Comparative Science (AWIS) had some unintentional undergraduates, graduates and Functional Genomics, New help. A now-infamous speech last year postdocs that will target ‘soft’ skills, York University. by Harvard University president Larry such as communication, leadership and 2002–03: Research assistant Summers, calling women’s scientific interviewing. Although necessary to professor, Rockefeller capabilities into question, brought in succeed in any career, these are not University, New York. many new members. usually introduced in academic courses. 1999–2002: Postdoc, AWIS was founded in 1971, dedicated MASS AWIS will also be establishing Rockefeller University, to promoting women’s full participation programmes and organizing mentors/ New York. in all scientific fields through education, volunteers to introduce the excitement 1998–99: Postdoc, Rutgers mentoring and job opportunities. AWIS of scientific discovery to school-age University, New Jersey. also serves as a political voice for girls. Every chapter event serves as a women in science, through testimonies valuable networking and mentoring “What field of science you belong to depends on what on Capitol Hill and participation in a resource for our members and guests. questions you’re asking,” says Nikolaus Rajewsky, who is number of coalitions.
    [Show full text]