From Data Acquisition to Motif Visualization
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In Silico Docking Analysis of CCL28 (CC Motif Chemokine Ligand
F1000Research 2019, 8:313 Last updated: 21 SEP 2021 RESEARCH ARTICLE In silico docking analysis of CCL28 (C-C motif chemokine ligand 28) and astragalin as the potential inhibitor of rheumatoid arthritis [version 1; peer review: 1 approved, 1 approved with reservations] Sadaf Noor, Syeda Tahira Qousain, Syed Aun Muhammad Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Punjab, 60800, Pakistan v1 First published: 20 Mar 2019, 8:313 Open Peer Review https://doi.org/10.12688/f1000research.18541.1 Latest published: 20 Mar 2019, 8:313 https://doi.org/10.12688/f1000research.18541.1 Reviewer Status Invited Reviewers Abstract Background: Rheumatoid arthritis is an inflammatory and chronic 1 2 disease of the joints affecting 1% of the world’s population. Women are three times more likely to be affected than men. Many drugs are version 1 being used for the treatment of rheumatoid arthritis but they often 20 Mar 2019 report report have severe side effects. C-C motif chemokine ligand 28 (CCL28) recruits leukocytes and other proinflammatory factors to the site of 1. Ihsan Ul Haq, Quaid-i-Azam University, joint inflammation. The purpose of the present research is the computational evaluation of astragalin, a natural flavonoid extracted Islamabad, Pakistan from black tea, as an inhibitor of CCL28 by in silico docking. 2. Sagarika Biswas, Institute of Genomics and Methods: The three-dimensional structure of CCL28 to act as a molecular target was obtained from the Protein Data Bank (PDB ID: Integrative Biology, New Delhi, India 6CWS). The quality of the CCL28 structure was assessed using Phyre2 and Molecular Operating Environment (MOE) software was used for Any reports and responses or comments on the binding affinity analysis. -
IP Log for Eclipse.Platform Release 4.0, July 2010 Licenses
IP Log for eclipse.platform Release 4.0, July 2010 Licenses • Eclipse Public License v1.0 Third-Party Code CQ Third-Party Code License Use ICU4J (core and extended ICU4J License (X License, 1065 function) and ICU4J MIT Style) Replacement plug-in Version: 3.6 ICU4J License (X License, 1116 ICU4J Version: 3.4.5.20061213 MIT Style) 1153 JSch 0.1.31 Version: 0.1.31 New BSD license Apache Lucene Version: 1.9.1 243 (Core+Contrib Analyzers Apache License, 2.0 Analysis Src) 257 APT Version: 1 New BSD license Mozilla Public License 1.1 (MPL), MIT Style with No 262 Cairo Version: 1.0.2 Endorsement Clause, Historical Permissive Notice & Disclaimer ICU4J License (X License, 280 ICU4J Version: 3.4 MIT Style) ICU4J License (X License, 281 ICU4J Version: 3.4.3 MIT Style) 293 jsch Version: 0.1.28 New BSD license 308 PNG unload Version: 1 MIT license 1232 Apache Ant Version: 1.7.0 Apache License, 2.0 ICU4J and ICU4J Replacement ICU4J License (X License, 1367 Version: 3.6.1 MIT Style) Olsen time zone data Version: 1368 Public Domain 2007e Work derived from IJG JPEG 1596 IJG License Version: Release 6b,337 unmodified 1826 JSch 0.1.35 New BSD license source & binary ICU4J and ICU4J replacement MIT License with "no unmodified 1919 Version: 3.8.1 edorsement" clause source & binary unmodified 2014 jsch Version: 0.1.37 New BSD license source & binary XHTML DTDs Version: unmodified 2044 W3C Document License Versions 1.0 and 1.1 (PB CQ331) source org.apache.ant Version: 1.6.5 2404 (ATO CQ1013) (using Orbit Apache License, 2.0 CQ2209) org.apache.lucene Version: 1.4.3 2405 (Core Source Only) (ATO Apache License, 2.0 CQ1014) (using Orbit CQ2210) Junit Version: 3.8.2 (ATO 2406 Common Public License 1.0 CQ299) (using Orbit CQ2206) Historical support for Java SSH modified 2410 Applet + Blowfish Version - v. -
The GNOME Desktop Environment
The GNOME desktop environment Miguel de Icaza ([email protected]) Instituto de Ciencias Nucleares, UNAM Elliot Lee ([email protected]) Federico Mena ([email protected]) Instituto de Ciencias Nucleares, UNAM Tom Tromey ([email protected]) April 27, 1998 Abstract We present an overview of the free GNU Network Object Model Environment (GNOME). GNOME is a suite of X11 GUI applications that provides joy to users and hackers alike. It has been designed for extensibility and automation by using CORBA and scripting languages throughout the code. GNOME is licensed under the terms of the GNU GPL and the GNU LGPL and has been developed on the Internet by a loosely-coupled team of programmers. 1 Motivation Free operating systems1 are excellent at providing server-class services, and so are often the ideal choice for a server machine. However, the lack of a consistent user interface and of consumer-targeted applications has prevented free operating systems from reaching the vast majority of users — the desktop users. As such, the benefits of free software have only been enjoyed by the technically savvy computer user community. Most users are still locked into proprietary solutions for their desktop environments. By using GNOME, free operating systems will have a complete, user-friendly desktop which will provide users with powerful and easy-to-use graphical applications. Many people have suggested that the cause for the lack of free user-oriented appli- cations is that these do not provide enough excitement to hackers, as opposed to system- level programming. Since most of the GNOME code had to be written by hackers, we kept them happy: the magic recipe here is to design GNOME around an adrenaline response by trying to use exciting models and ideas in the applications. -
A Highly Interactive Expert System for Outside Plant Engineering
From: IAAI-93 Proceedings. Copyright © 1993, AAAI (www.aaai.org). All rights reserved. OPERA: A Highly Interactive Expert System for Outside Plant Engineering Gary Lazarus, Lien ‘Ihn and Marty Baade Expert Systems Laboratory NYNEX Science & Technology 500 Westchester Avenue White Plains, NY 10604 [email protected] Abstract system that contains more engineering expertise than OPERA is an expert system developed at the Expert any single engineer in the telephone companies. Systems Laboratory at NYNEX Science & Technology to As is the case in most high technology fields, assist outside plant telecommunications engineers in the outside plant engineers routinely see new products, or planning and implementation of sophisticated electronic refinements and enhancements to existing ones. The equipment. The engineer communicates with the system via underlying first order principles of engineering are intelligent documents that are schematic in their design and complex and not necessarily fully understood by all dynamic in their operation to facilitate the conveyance of necessary and sufficient information. Expertise from the top engineers charged with the responsibility of turning up experts in the company was culled and built into the system working systems. Engineers who immerse themselves in to create an expert system that surpasses the engineering the latest technology can perform very well. But, the knowledge of any single engineer in the company. The effort required to maintain that ability is significant. domain and project objectives are discussed, the system OPERA (Outside Plant Engineering and Resource architecture and development, testing, deployment and Administration), therefore, must provide a reasoning maintenance issues are presented and the use of artificial mechanism that emulates the best engineers and be intelligence techniques is justified. -
Program Book
Pacific Symposium on Biocomputing 2016 January 4-8, 2016 Big Island of Hawaii Program Book PACIFIC SYMPOSIUM ON BIOCOMPUTING 2016 Big Island of Hawaii, January 4-8, 2016 Welcome to PSB 2016! We have prepared this program book to give you quick access to information you need for PSB 2016. Enclosed you will find • Logistics information • Menus for PSB hosted meals • Full conference schedule • Call for Session and Workshop Proposals for PSB 2017 • Poster/abstract titles and authors • Participant List Conference materials are also available online at http://psb.stanford.edu/conference-materials/. PSB 2016 gratefully acknowledges the support the Institute for Computational Biology, a collaborative effort of Case Western Reserve University, the Cleveland Clinic Foundation, and University Hospitals; the National Institutes of Health (NIH), the National Science Foundation (NSF); and the International Society for Computational Biology (ISCB). If you or your institution are interested in sponsoring, PSB, please contact Tiffany Murray at [email protected] If you have any questions, the PSB registration staff (Tiffany Murray, Georgia Hansen, Brant Hansen, Kasey Miller, and BJ Morrison-McKay) are happy to help you. Aloha! Russ Altman Keith Dunker Larry Hunter Teri Klein Maryln Ritchie The PSB 2016 Organizers PACIFIC SYMPOSIUM ON BIOCOMPUTING 2016 Big Island of Hawaii, January 4-8, 2016 SPEAKER INFORMATION Oral presentations of accepted proceedings papers will take place in Salon 2 & 3. Speakers are allotted 10 minutes for presentation and 5 minutes for questions for a total of 15 minutes. Instructions for uploading talks were sent to authors with oral presentations. If you need assistance with this, please see Tiffany Murray or another PSB staff member. -
Conference Proceedingssmall
1 COMMITTEES Steering Committee Phil Bourne - University of California, San Diego Eric Davidson - California Institute of Technology Steven Salzberg - The Institute for Genomic Research John Wooley - University of California San Diego, San Diego Supercomputer Center Organizing Committee Pat Blauvelt – LSS Membership Director Karen Hauge – Palo Alto Medical Foundation, Local Arangements Kass Goldfein - Finance Consultant AlishaHolloway – The J. David Gladstone Institutes, Tutorial Chair Sami Khuri – San Jose State University, Poster Chair Ann Loraine – University of North Carolina at Charlotte, CSB Publication Chair Fenglou Mao – University of Georgia, On-Line Registration and Refereeing Website Peter Markstein – in silico Labs, Program Co-Chair Vicky Markstein - Life Sciences Society, Conference Chair, LSS President Jean Tsukamoto - Graphics Design Bill Wang - Sun Microsystems Inc, LSS Information Technology Director Ying Xu – University of Georgia, Program Co-Chair Program Committee Tatsuya Akutsu – Kyoto University Chris Bailey-Kellogg – Dartmouth College Pierre Baldi – University of California Irvine Liming Cai – University of Georgia Bill Cannon – Pacific Northwest National Laboratory Jake Chen – Indiana University Bhaskar DasGupta – University of Illinois Chicago Andrey Gorin – Oak Ridge National Laboratory Matt Hibbs – Princeton University Wen-Lian Hsu – Academia Sinica Tamer Kahveci – University of Florida Carl Kingsford – University of Maryland Christina Leslie – Memorial Sloan-Kettering Cancer Center Jing Li – Case Western Reserve -
Testing X/Motif Applications
TTeessttiinngg XX//MMoottiiff AApppplliiccaattiioonnss Achieving Quality Goals Through Automated GUI Testing Integrated Computer Solutions Incorporated The User Interface Company™ Phone: 617.621.0060 Email: [email protected] www.ics.com Automated Testing of X-Window Applications Choosing the Ideal Tool for Automated GUI Testing Table of Contents Overview............................................................................................................................. 3 The importance of GUI testing ........................................................................................... 3 Exploratory testing.......................................................................................................... 3 Regression testing ........................................................................................................... 3 Boundary testing ............................................................................................................. 4 Stress testing ................................................................................................................... 4 GUI Testing Tools .............................................................................................................. 4 Developing initial GUI tests ............................................................................................... 5 Using a GUI test tool during exploration............................................................................ 6 Basic scripting.................................................................................................................... -
Decwindows Motif for Openvms Installation Guide
VSI OpenVMS DECwindows Motif for OpenVMS Installation Guide Document Number: DO-DDWINS-01A Publication Date: October 2019 Revision Update Information: This is a new manual. Operating System and Version: VSI OpenVMS Integrity Version 8.4-1H1 VSI OpenVMS Alpha Version 8.4-2L1 Software Version: DECwindows Motif for OpenVMS Version 1.7F VMS Software, Inc., (VSI) Bolton, Massachusetts, USA DECwindows Motif for OpenVMS Installation Guide Copyright © 2019 VMS Software, Inc. (VSI), Bolton, Massachusetts, USA Legal Notice Confidential computer software. Valid license from VSI required for possession, use or copying. Consistent with FAR 12.211 and 12.212, Commercial Computer Software, Computer Software Documentation, and Technical Data for Commercial Items are licensed to the U.S. Government under vendor's standard commercial license. The information contained herein is subject to change without notice. The only warranties for VSI products and services are set forth in the express warranty statements accompanying such products and services. Nothing herein should be construed as constituting an additional warranty. VSI shall not be liable for technical or editorial errors or omissions contained herein. HPE, HPE Integrity, HPE Alpha, and HPE Proliant are trademarks or registered trademarks of Hewlett Packard Enterprise. The VSI OpenVMS documentation set is available on DVD. ii DECwindows Motif for OpenVMS Installation Guide Preface .................................................................................................................................... -
Press Release
Press Release No. 30/December 14, 2011 Press2011_Leibniz-Prize_Nikolaus_Rajewsky Nikolaus Rajewsky of the MDC to Receive the Leibniz Prize – the Highest Honor Awarded in German Research Professor Nikolaus Rajewsky of the Max Delbrück Center for Molecular Medicine (MDC) Berlin is to receive Germany’s most prestigious research award, the Gottfried Wilhelm Leibniz Prize. The announcement was made by the German Research Foundation (DFG) on Thursday, December 8, 2011. This is the second time the prize will go to the MDC. In 2002 Professor Carmen Birchmeier received the award. In 2012 the prize will be awarded to a total of eleven scientists: two women and nine men were selected from among 131 nominations. The Leibniz Prizes, each endowed with up to 2.5 million euros, will be presented in an award ceremony in Berlin on February 27, 2012. Nikolaus Rajewsky is Professor of Systems Biology at the MDC and the Charité and Scientific Director of the “Berlin Institute for Medical Systems Biology” (BIMSB) at the MDC. Systems biology combines molecular biology, biochemistry, mathematics and physics in order to quantitatively capture and predict complex processes of life. Professor Rajewsky’s research activities focus mainly on microRNAs, a group of genes discovered only a few years ago. As Nikolaus Rajewsky has demonstrated experimentally and with the aid of bioinformatics, microRNAs play an important role in the regulation of genes, including those that play a crucial role in the development of diseases. This discovery opens up a huge field of potential applications, including target structures for novel therapy approaches. In addition, Professor Rajewsky and his group have also made important methodological and technological advances. -
Pacific Symposium on Biocomputing 2020 January 3-7, 2020 Big Island of Hawaii
Pacific Symposium on Biocomputing 2020 January 3-7, 2020 Big Island of Hawaii Program Book PACIFIC SYMPOSIUM ON BIOCOMPUTING 2020 Big Island of Hawaii, January 3-7, 2020 Welcome to PSB 2020! We have prepared this program book to give you quick access to information you need for PSB 2020. Enclosed you will find: • Logistics information • Medical services information • Full conference schedule (see website for the latest version) • Agendas for workshops and JBrowse demo • Call for Session and Workshop Proposals for PSB 2021 • Poster/abstract titles and author index • Participant list The latest conference materials are available online at http://psb.stanford.edu/conference-materials/. PSB 2020 gratefully acknowledges the support of the Cleveland Institute for Computational Biology; UPenn Institute for Biomedical Informatics; Variant Bio; Penn Center for Precision Medicine, Penn Medicine; Cipherome; Translational Bioinformatics Conference (TBC); the National Institutes of Health (NIH); and the International Society for Computational Biology (ISCB). If you or your institution are interested in sponsoring, PSB, please contact Tiffany Murray at [email protected] If you have any questions, the PSB registration staff (Tiffany Murray, Kasey Miller, BJ Morrison-McKay, and Cindy Paulazzo) are happy to help you. Aloha! Russ Altman Keith Dunker Larry Hunter Teri Klein Maryln Ritchie The PSB 2020 Organizers PACIFIC SYMPOSIUM ON BIOCOMPUTING 2020 Big Island of Hawaii, January 3-7, 2020 SPEAKER INFORMATION Oral presentations of accepted proceedings papers will take place in Salon 2 & 3. Speakers are allotted 10 minutes for presentation and 5 minutes for questions for a total of 15 minutes. Instructions for uploading talks were sent to authors with oral presentations. -
Daniel Aalberts Scott Aa
PLOS Computational Biology would like to thank all those who reviewed on behalf of the journal in 2015: Daniel Aalberts Jeff Alstott Benjamin Audit Scott Aaronson Christian Althaus Charles Auffray Henry Abarbanel Benjamin Althouse Jean-Christophe Augustin James Abbas Russ Altman Robert Austin Craig Abbey Eduardo Altmann Bruno Averbeck Hermann Aberle Philipp Altrock Ferhat Ay Robert Abramovitch Vikram Alva Nihat Ay Josep Abril Francisco Alvarez-Leefmans Francisco Azuaje Luigi Acerbi Rommie Amaro Marc Baaden Orlando Acevedo Ettore Ambrosini M. Madan Babu Christoph Adami Bagrat Amirikian Mohan Babu Frederick Adler Uri Amit Marco Bacci Boris Adryan Alexander Anderson Stephen Baccus Tinri Aegerter-Wilmsen Noemi Andor Omar Bagasra Vera Afreixo Isabelle Andre Marc Baguelin Ashutosh Agarwal R. David Andrew Timothy Bailey Ira Agrawal Steven Andrews Wyeth Bair Jacobo Aguirre Ioan Andricioaei Chris Bakal Alaa Ahmed Ioannis Androulakis Joseph Bak-Coleman Hasan Ahmed Iris Antes Adam Baker Natalie Ahn Maciek Antoniewicz Douglas Bakkum Thomas Akam Haroon Anwar Gabor Balazsi Ilya Akberdin Stefano Anzellotti Nilesh Banavali Eyal Akiva Miguel Aon Rahul Banerjee Sahar Akram Lucy Aplin Edward Banigan Tomas Alarcon Kevin Aquino Martin Banks Larissa Albantakis Leonardo Arbiza Mukul Bansal Reka Albert Murat Arcak Shweta Bansal Martí Aldea Gil Ariel Wolfgang Banzhaf Bree Aldridge Nimalan Arinaminpathy Lei Bao Helen Alexander Jeffrey Arle Gyorgy Barabas Alexander Alexeev Alain Arneodo Omri Barak Leonidas Alexopoulos Markus Arnoldini Matteo Barberis Emil Alexov -
German Immunologist Receives Ernst Schering Prize
PRESSEINFORMATION Retired in Germany, successful at Harvard: German immunologist receives Ernst Schering Prize Klaus Rajewsky receives the Ernst Schering Prize 2008 for his outstanding research in the area of analysis, development, activation and differentiation of B-lymphocytes. Berlin, 7th of October 2008 Today Professor Klaus Rajewsky from the Immune Disease Institute of Harvard Medical School, Boston, USA receives the Ernst Schering Prize 2008 for his pioneering work in the area of B-cell-biology. With his research he has significantly contributed to our understanding of B-lymphocytes as well as the development of certain lymphatic cancers, the so called lymphomas. Since his discovery that B-cells from germinal centres are the tumour cells of Hodgkin’s Lymphoma, Rajewksy and his team have been working on reconstructing the pathogenic course of the disease in a mouse model. Using the technology of conditional gene targeting, which was developed by Rajewsky, they aim to reveal the genetic background of the disease. The 50.000 Euro Ernst Schering Prize will be awarded to the laureate during a ceremony in Berlin. By awarding the Ernst Schering Prize to Klaus Rajewsky the Schering Foundation wishes to draw attention to the loss of outstanding German researchers due to strict retirement regulations in the German academic system. Rajewsky, who was forced to retire as an active researcher after almost thirty years at the University of Cologne, took up professorship at the University of Harvard, where he still heads a successful and productive research group. “The German retirement regulations would have resulted in shaky financial conditions for my group in Cologne”, Rajewsky recalls.