INDEX

Abreu, B. E., Richards, A. B., Weaver, L. Azide, effect of, on carotid chemoreceptor C., Burch, G. R., Bunde, C. A., Bock- activity, 46 stahler, E. R., and Wright, D. L. Pharmacologic properties of 4-alkoxy- BAL, see Dimercaprol $-(1-piperidyl)propiophenones, 419 Barbiturates, effect on actions of, of several Acetazoleamide, anticonvulsant potency in analgetic agents, 21 mice, and mechanism, 251 Barbituric acid: 5-ethyl,5(1-methyl,2- Acheson, G. H., see Kahn, J. B., Jr., 305 carboxyethyl), determination in urine, Adrenal cortex, effect of DDD derivatives metabolite of butabarbital, 275 on, 408 5-ethyl,5(1-methyl, 2-carboxyethyl), Adrenal gland, ascorbic acid, and thyroid, ethyl ester derivative, 275 144 Barsoum, H. Colchicine and spermatogene- Adrenergic blockade, effect on responses to sis, 319 sympathomimetic amines, 323 Bass, A. D., see Diermeier, H. F., 240 Agarwal, S. L., see Timiras, P. 5., 154 Benzoquinonium, substitution in, and ac- Alcohol, see Ethanol tivity of, 106 Alloxan, effect on liver DNA, 240 Bergner, A. D., see Murtha, E. F., 291 Alseroxylon, vasomotor effects, 464 Bhargava, K. P., and Borison, H. L. Effects Ammonium chloride, anticonvulsant po- of Rauwolfia alkaloids on hypothalamic, tency in mice, 251 medullary and spinal vasoregulatory Amphetamine, effects upon tracking be- systems, 464 havior, 480 Bioassay, of reserpine, pigeon emesis, 55 Anderson, H. L., Jr., see Ellis, 5., 120 Bockstahler, E. R., see Abreu, B. E., 419 Anesthetics, effects of on myocardium, 206 Borison, H. L., see Bbargava, K. P., 464 general, hydroxydione, 432 Boxill, G. C., and Brown, R. V. Blood pres- local, series of diamino propionic acid sure responses to epinephrine in dogs anilides, 246 with certain humoral backgrounds, I Anhydrochiortetracycline, effect of Brain stem, arousal, drugs on, 449 metallic cations on, 61 Brill, I. C., see Lahti, R. E., 268 Anilides, diamino propionic acid, as local Brodie, B. B., see Fouts, J. R., 68 anesthetics, 246 Brown, B., Schaffarzick, R. W., and Dreis- Anticholinesterase agents, bis-quaternary bach, R. H. Anticonvulsant properties oxamides, 185 of certain secondary and tertiary alco- Anticonvulsant drugs, carbinols as, 230 hols, 230 see Nikethamide Brown, R. V., see Boxill, G. C., 1 Arnold, A., see Lands, A. M., 185 Bunde, C. A., see Abreu, B. E., 419 Arora, S. B., and Sharma, V. N. Local anes- Burch, G. R., see Abreu, B. E., 419 thetic and pharmacologic properties of Butabarbit.al, determination in plasma and 4n-butoxy fl-(1-piperidyl)propiophenone urine, 275 HC1 and -diethylaminoethyl p-n- metabolic fate in (logs, and rate of metab- hexyloxybenzilate HC1, 413 olism, 275 Atropine, metabolism of, in mice, 217 Butisol, see Butaharbital radioactive, 217 Cafruny, E. J., Farah, A., and Di Stefano, Aviado, D. M., Jr., Cerletti, A., Li, T. H., H. S. Effects of the mercurial diuretic, and Schmidt, C. F. Activation of mersalyl, on protein-bound sulfhydryl carotid sinus pressoreceptors and intra- groups in the cytoplasm of rat kidney cranial receptors by veratridine and cells, 390 potassium, 329 Carbinols, as anticonvulsants, 230 Axelrod, J. Enzymatic conversion of codeine Carbonic anhydrase, effect of acetazole- to morphine, 259 amide, and other depressants, 251

485 486 INDEX

Cardiac function, effects of anesthetics on, Digitoxin, metabolic fate, 371 206 Dimercaprol, on ventricular muscle, 300 measurement of, 199 Diphenhydramine, effects upon tracking Cardiac glycosides, see Digitoxin behavior, 480 Cardiac muscle, effect of diphenylhydantoin Diphenylhydantoin, effect on brain car- on electrolytes, 74 bonic anhydrase, 74 Cardiac pharmacology, impulse origination effect on electrolyte changes following in rabbit atria, 283 maximal electroshock seizures, 74 Carotid chemoreceptors, effect on, of vari- effect on electroshock seizure threshold, ous compounds, 46 74 Cations, transfer in red cells, 305 effect on radiosodium distribution, 74 Cerebral cortex, effect of diphenylhydan- effect on tissue electrolytes, 74 tom on electrolytes, 74 Di Stefano, H. S., see Cafruny, E. J., 390 influence of Metrazol and thiosemicarb- see Diermeier, H. F., 240 azide on electrical activity of isolated, Domino, E. F. Pharmacological analysis of 28 the functional relationship between the Cerletti, A., see Aviado, D. M., Jr., 329 brain stem arousal and diffuse thalamic Chemoreceptors, carotid. effect on, of vari- projection systems, 449 ous drugs, 46 Dontas, A. S. Effects of energy donors, Chlorisondamine dimethochloride, as metabolic inhibitors and substrates on ganglionic blocking agent, 172 carotid chemoreceptor activity, 46 Cholinesterase, inhibition of, by bis-quater- Dreisbach, R. H., see Brown, B., 230 nary oxamides, 185 Dyclonine, pharmacology of, 419 Chumakow, N., see Walkenstein, S., S., 16 Codeine, enzymatic conversion to mor- Earl, A. E., Winters, R. L., and Schneider, phine, 259 C. M. Assay of reserpine based on eme- Colchicine, on spermatogenesis, 319 sis in pigeons, 55 Competence index, significance of, 199 see Plummer, A. J., 172 Cooper, T. W., see Walters, P. A., Jr., 323 Edberg, L. J., see Murtha, E. F., 291 Curare -like action, see Benzoquinonium, Electroshock seizure, maximal, effect of 106 acetazoleamide, 251 Curry, J. H., Jr., see Okita, G. T., 371 threshold, effect of diphenyihydantoin, 74 Cyanide, effect of, on carotid chemoreceptor threshold, effect of hyponatremia, 74 activity, 46 Ellis, S., Davis, A. H., and Anderson, H. L., Cyclizine, effects upon tracking behavior, Jr. Effects of epinephrine and related 480 amines on contraction and glycogenoly- Cyclopropane, on myocardial function, 206 sis of the rat’s diaphragm, 120 Cvsteine, on ventricular muscle, 300 Emesis, in pigeon, as assay for reserpine, 55 Davis, A. H., see Ellis, S., 120 Ephedrine, contraction and glycogenolysis, DDD, effect. of derivatives on adrenal cor- rat diaphragm, 120 tex, 408 Epinephrine, blood pressure responses to, Denison, A. B., Jr., see Walters, P. A., Jr., influenced by hormones, 1 323 contraction and glycogenolysis, rat dia- Dews, P. B. Studies on behavior. II. Ef- phragm, 120 fects of pentobarbital methampheta- responses to, in vascular beds, effects on mine and scopolamine on performances of adrenergic block, 323 in pigeons involving discriminations, Erythrocytes, cation transfer in, effect on, 380 of glycosides and lactones, 305 Diamox, see Acetazoleamide Estrogens, and uterine permeability, 442 Diermeier, H. F., Di Stefano, H. S., and Ethanol, metabolism in rat, 360 Bass, A. D. Effect of alloxan on liver DNA of the rat, 240 Ether, diethyl, effects of, on brain mech- 3-Diethylaminoethyl p-n-hexyloxyhenzilate anisms, 449 HC1, pharmacology of, 413 diethyl, on myocardial function, 206 INDEX 487

F:i mb , .. . , see Cafruny , F . J . , 390 Hexabarbital, see Barbiturates Fatigue, effects of analeptic drugs upon, 480 Hoppe, J. 0., Funnell, J. E., and Lape, H. Finnegan, J. K., see Larson, P. S., 408 Effects of structural variation in the Iouts, J. R., and Brodie, B. B. Inhibition quaternary nitrogen centers of benzo. of drug metabolic pathways by the quinonium chloride upon neuromuscu- potentiating agent 2, 4-dichloro-6-phen- lar blocking activity, 106 ylphenoxyethyl diethylamine, 68 Howard, J. W., see Lands, A. M., 185 Funnell, J. E., see Hoppe, J. 0., 106 Hutcheon, D. E., see P’an, S. V., 432 Fujimori, H., see Garb, S., 300 Hydroxydione, anesthetic action of, 432 Hypoglycemia produced by mesoxalate, 343 Gahourel, J. D., see Gossehin, R. E., 217 Hypothalamus, effects on, of Rauwoifia, 464 Ganglionic blockade, by chlorisondamine dimet.hochloride, 172 Insulin liberation by mesoxalate, 343 Garb, S., Scriabine, A., Penna, M., and Isobol, of nikethamide-phenoharbital com- Fujimori, H. Effects of reduced glu- binations, 6 tathione and related substances on the Isoproterenol, contraction and glycogenoly- threshold of irritability of mammalian sis, rat diaphragm, 120 ventricular muscle, 300 responses to, in vascular beds, effects on, Gardocki, J. F., see P’an, S. Y., 432 of adrenergic block, 323 Geiling, E. M. K., see Okita, G. T., 371 Gilfoil, T. M., see Miller, J. W., 350 Kahn, J. B., Jr., and Acheson, G. H. Ef- Glassman, J. M., and Seifter, J. Effects of fects of cardiac glycosides and other analgesic agents on barbiturate re- lactones, and of certain other com- sponses in mice, 21 pounds, on cation transfer in human Glucuronic acid, determination in urine erythrocytes, 305 aft.e r administration of hutabarbital, Kalman, S. M. Some studies on estrogens 275 and uterine permeability, 442 Glutathione, on ventricular muscle, 300 Kaiser, S. C., see Gosseiin, R. E., 217 Glycine, on ventricular muscle, 300 Karczmar, A. G., see Lands, A. M., 185 Glycogenolysis, effect of sympathomimetic Keasling, H. H., see Vim, G. K. W., 96 amines, 120 Kelly, J. M., see Numerof, P., 427 Glycosides, cardiac, see Digitoxin Kidney-SH groups and mercurial diuresis, effect of, on cation transfer, in red cells, 390 305 Kobayashi, Y., and Ohashi, S. Hypogly- Goodman, L. S., see Millichap, J. G., 251 cemic effect of mesoxalate produced by Gordon, M., see Numerof, P., 427 infusion into pancreatic circulation in Gosselin, H. E., Gahourel, .1. D., Kaiser, the dog, 343 S. C., and Wills, J. H. Metabolism of Kodet, M. J., see P’an, S. V., 432 C’4-labeled atropine and tropic acid in mice, 217 Lactones, effect of, on cation transfer, in red cells, 305 ---, and Megirian, R. Influence of chain length on the metabolic fate of con- Lahti, R. E., Brill, I. C., and McCawley, densed phosphates, 402 E. L. Effect of methoxamine hydro- Green, H. D., see Walters, P. A., Jr., 323 chloride (Vasoxyl) on cardiac rhythm, Gross, E. G., see Vim, G. K. W., 96 268 Lands, A. M., Karczmar, A. G., Howard, haag, H. B., see Larson, P. S., 408 J. W., and Arnold, A. An evaluation of Heart muscle, glutathione on threshold of the pharmacologic actions of some his- irritability, 300 quaternary salts of basically substi- Helrich. M., see Price, H. L., 199, 206 tuted oxamides (WIN 8077 and ana- hlemiacetals, quaternary ammonium salts logs), 185 of as respiratory paralyzants, 127 Lape, H., see Hoppe, J. 0., 106 “Hemicholiniums”, a new group of respira- Larson, P. S., Hennigar, G. H., Finnegan, tory paralyzants, 127 .J. K., Smith, R. B., Jr., and Haag, H. Hennigar. Ci. H., see Larson, P. S., 408 B. Observations on the relation of 488 INDEX

chemical structure to the production of Methoxamine, and cardiac rhythm, 268 adrenal cortical atrophy or hypertrophy Metrazol, see Pentylenetetrazole in the dog by derivatives of 2,2-bis- Mihlichap, J. G., Woodbury, D. M., and

(p-chlorophenyl) - 1,1 - dichloroethane Goodman, L. S. Mechanism of the (DDD, TDE), 408 anticonvulsant action of acetazole- Laubach, G. D., see P’an, S. Y., 432 amide, a carbonic anhydrase inhibitor, Levallorphan, effect of, on respiration of 251 rabbits given morphine, 350 Miller, J. W., Gilfoil, T. M., and Shideman, effect on rabbit tooth pulp threshold and F. E. Effects of levallorphan tartrate respiratory minute volume with or (levo-3-hydroxy-N-allyimorphinan tar- without levorphan, 96 trate) on the respiration of morphinized Levarterenol, contraction and glycogenoly- rabbits, 350 sis, rat diaphragm, 120 Mitchell, C. W., see Yim, Ci. K. W., 96 responses to, in vascular beds, effects on, Moore, E. W., see Payne, R. B., 480 of adrenergic block, 323 Morphine, and respiration, effect of leval- Levorphan, effect on rabbit tooth pulp orphan, 350 threshold and respiratory minute vol- effect on rabbit tooth pulp threshold and ume with or without levallorphan, 96 respiratory minute volume, 96 Li, T. H., see Aviado, D. M., Jr., 329 enzymatic conversion from codeine, 259 Lilly 18947, a potentiating agent, 68 Motion sickness, effects of remedies upon Liver, DNA, effect on, of ailoxan, 240 behavior, 480 Loewe, S. Isobols of dose-effect relations in Murtha, E. F., McNamara, B. P., Edberg, the combination of nikethamide (Cora- L. J., Bergner, A. D., and Wills, J. H. mine) and phenobarbital, 6 Studies on the pharmacology of tetra- Losin, L., see Maynert, E. W., 275 ethylpyrophosphate, 291 Mycobacterium tuberculosis, enzymes, ef- Marshall, E. K., Jr., see Owens, A. H., Jr., fect on, of purines and pyrimidines, 339 360 Myocardial contractility, measurement of, Maynert, E. W., and Losin, L. Metabolism 199 of butabarbital (Butisol) in the dog, Myocardium, effects of anesthetics on, 206 275 McCawley, E. L., see Lahti, R. E., 268 Neuromuscular junction, action on, of bis- McNamara, B. P., see Murtha, E. F., 291 quaternary oxamides, 185 Meclizine, effects upon tracking behavior, Nikethamide, and phenobarbital com- 480 binations, 6 Medulla, effects on, of Rauwolfia, 464 Nitrous oxide, on myocardiai function, 206 Megirian, R., see Gosselin, R. E., 402 Nucleic acids, of liver, effect on, of alloxan, Meperidine, actions of, on effects of bar- 240 biturates, 21 Numerof, P., Gordon, M., amid Kelly, J. M. Mephenesin, effects of, on brain mecha- Metabolism of reserpine. I. Studies in nisms, 449 the mouse with C-14 labeled reserpine, Mephentermi ne, detoxication and excre- 427 tion of, 16 effects upon tracking behavior, 480 Ohashi, S., see Kobayashi, V., 343 Mercurial diuresis and -SH groups of kid- Okita, G. T., Talso, P. J., Curry, J. H., Jr., ney, 390 Smith, F. D., Jr., and Geiling, E. M. K. Mesoxalate, action on pancreas, 343 Metabolic fate of radioactive digitoxin hypoglycemia produced by, 343 in human subjects, 371 liberation of insulin, 343 Ottey, L. Effect of purine and pyriniidine Metallic cations, effect on anhydrochlor- analogues on enzyme induction in tetracycline, 61 mycobacteriuin tuberculosis, 339 Methamphetamine, effect of, on discrimina- Owens, A. H., Jr., and Marshall, E. K., Jr. tory performance in pigeons, 380 Metabolism of ethyl alcohol in the rat, Methionine, on ventricular muscle, 300 360 INDEX 489

P’an, S. V., Gardocki, J. F., Hutcheon, D. in the measurement of myocardial con- E., Rudel, H., Kodet, M. J., and tractility, 199 Laubach, Ci. D. General anesthetic and Promethazine, effects upon tracking be- other pharmacological properties of a havior, 480 soluble steroid, 21-hydroxypregnane- Propiophenone, 4n-butoxy-$-(1 -piperidyl), dione sodium succinate, 432 pharmacology of, 413 Pancreas, effect of mesoxalate on, 343 pharmacology of, 419 Payne, R. B., and Moore, E. W. Effects of Purine analogues, effect of, on enzyme in- some analeptic and depressant drugs duction in bacteria, 339 upon tracking behavior, 480 Pyrimidine analogues, effect of, on enzyme Penna, M., see Garb, 5., 300 induction in bacteria, 339 Pentobarbital, effects of, on brain mecha- Pyrophosphate, tetraethyl-, pharmacology nism, 449 of, 291 effect of, on discriminatory performance in pigeons, 380 Quaternary ammonium compounds, bis- see Barbiturates quaternary blocking series, 172 Pentylenetetrazole, influence of, on elec- bis-quaternary oxamides, 185 trical activity of isolated cerebral cor- effect of substitution on activity of tex, 28 benzoquinonium, 106 Petersen, P. V., see Weidmann, H., 246 Q uaternary ammonium hemiacetals, res- Phenobarbital, and nikethamide com- piratory paralyzant action, 127 binations, 6 Rauwolfia, central effects of, 464 effect on brain carbonic anhydrase, 251 alkaloids, see Re.serpine Phenylephrine, contraction and glyco- Reserpine, assay of, by pigeon emesis, 55 genolysis, rat diaphragm, 120 central effects of, 464 Phenylhexamethylenimines, actions of, on metabolism of, 427 effects of barbiturates, 21 Respiration, effect on, of veratridine and Phosphates, condensed, metabolic fate, 402 potassium, 329 high energy, effect of, on carotid chemo- levallorphan-morphine antagonism, 350 receptor activity, 46 Respiratory paralyzant, quaternary am - Pipradrol, effects upon tracking behavior, monium hemiacetals or “hemicholi- 480 niums”, 127 Plummer, A. J., Trapold, J. H., and Earl, Richards, A. B., see Abreu, B. E., 419 A. E. Ganglionic blockade by a new Rudel, H., see P’an, S. V., 432 bis-quaternary series, including ebb- risondamine dimethochloride (Su-3088), Schaffarzick, R. W., see Brown, B., 230 172 Schmidt, C. F., see Aviado, D. M., Jr., 329 Potassium, activation of receptors by, 329 Schneider, C. 1., see Earl, A. E., 55 transfer in red cells, 305 Schueler, F. W. New group of respiratory Potentiating agent, Lilly 18947, 68 paralyzants. I. “Hemicholiniums”, 127 Preston, J. B. Influence of thiosemicar- Scopolamine, effect of, on discriminatory hazide on electrical activity recorded in performance in pigeons, 380 the anterior brain stem of the cat, 39 effects upon tracking behavior, 480 -. Metrazol and thiosemicarbazide: a study Scriabine, A., see Garb, S., 300 of convulsant activity in the isolated Seifter, J., see Gla.ssman, J. M., 21 cc rebral cortex preparation, 28 see Walkenstein, S. S., 16 Price, H. L., and Helrich, M. Effect of Sharma, V. N., see Arora, S. B., 413 cycbopropane, diethyl ether, nitrous Shideman, F. E., see Miller, J. \V., 350 oxide, thiopental, and hydrogen ion Smith, F. D., Jr., see Okita, G. T., 371 concentration on the myocardial func- Smith, R. B., Jr., see Larson, P. S., 408 tion of the (log heart-lung preparation, Sodium, transfer in red cells, 305 206 Spermatogenesis, effect on, of colchicine, 319

-. Significance of the competence index Spinal cord, effects on, of Rauwolfia, 464 490 INDEX

Sulfanilamide, anticonvulsant potency in on seizure pattern, 154 mice, 251 on thymus weight, 144 carbonic anhydrase inhibitory potency, on tissue water and electrolytes, 154 251 Trimethadione, effect on brain carbonic Sulfathiazole, anticonvuisant effect in mice, anhydrase, 251 251 Tropic acid, metabolism of, in mice, 217 Sulfhydryl groups of kidney and mercurial diuresis, 390 Uterus, permeability, estrogens and, 442

Talso, P. J., see Okita, G. T., 371 Veratridine, activation of receptors by, 329 TEPP, experiments on, 291 Viadril, see Hydroxydione Thalamic projection, drugs on, 449 Walkenstein, S. S., Chumakow, N., and Thiopental, on myocardial function, 206 Seifter, J. Detoxication and excretion Thiosemicarbazide, influence of, on elec- of mephentermine, 16 trical activity of isolated cerebral cor- Walters, P. A., Jr., Cooper, T. W., Denison, tex, 28; influence of, on subcortical A. B., Jr., and Green, H. D. Dilator activity in the cat, 39 responses to isopropylarterenol in cu- Thyroxine, on adrenal ascorbic acid, and taneous and skeletal muscle vascular adrenal weight, 144 beds; effects of adrenergic blocking on body temperature, 154 drugs, 323 on brain excitability, 154 Weaver, L. C., see Abreu, B. E., 419 on liver glycogen, 144 Weidmann, H., and Petersen, P. V. Local on postictal recovery, 154 anesthetic action of a series of diamino on seizure pattern, 154 propionic acid anilides, 246 on thymus weight, 144 Weinberg, E. D. Effect of metallic cations on tissue water and electrolytes, 154 on the anti-streptomyces activity of Timiras, P. S., and Woodbury, D. M. anhydrochbortetracycline, 61 Adrenocortical function after adminis- West, T. C. Ultramicroelectrode recording tration of thyroxine and triiodothy- from the cardiac pacemaker, 283 ronine in rats, 144 Wills, J. H., see Gosselin, R. E., 217 -, Woodhury, D. M., and Agarwal, S. L. see Murtha, E. F., 291 Effect of thyroxine and triiodothyro- Winters, R. L., see Earl, A. E., 55 nine on brain function and electrolyte Woodbury, D. M. Effect of diphenyihy- distribution in intact and adrenalec- dantoin on electrolytes and radio- tomized rats, 154 sodium turnover in brain and other Tooth pulp threshold changes following tissues of normal, hyponatremic and morphine, bevorphan and levorphan- postictal rats, 74 levalborphan mixtures, 96 see Millichap, J. G., 251 Tracking behavior, effects of drugs upon, see Timiras, P. S., 144, 154 480 Wright, D. L., see Abreu, B. E., 419 Trapold, J. H., see Plummer, A. J., 172 Triiodothyronine, on adrenal ascorbic acid, Vim, Ci. K. W., Keasling, H. H., Gross, E. and adrenal weight, 144 G., and Mitchell, C. W. Simultaneous on body temperature, 154 respiratory minute volume and tooth on brain excitability, 154 pulp threshold changes following levor- on liver glycogen, 144 phan, morphine and levorphan-leval- on postictal recovery, 154 lorphan mixtures in rabbits, 96