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INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas

About the Event The International Space Medicine Summit (ISMS) 2015 brings together the world’s leading physicians, space biomedical scientists, engineers, , cosmonauts and educators from the spacefaring nations for high- level discussions to identify not only necessary space medicine research goals but also ways to further enhance international cooperation and collaborative research. All International Space Station (ISS) partners will be represented at the summit.

International cooperation is essential to the human exploration of space. ISMS 2015 will celebrate the 40th anniversary of the Apollo- Test Project (ASTP) mission, the beginning of a relationship that now has become the foundation of the ISS. Extra-Vehicular Activity (EVA) has also played a major role in the assembly and maintenance of the ISS. ISMS 2015 celebrates the 50th anniversary of the world’s first EVA, performed by cosmonaut Alexei Leonov in March 1965.

As we plan to return to the moon, and eventually land on Mars, international cooperation continues to play an essential role. There must be much more research to prevent and/or mitigate the medical, psychological and biomedical challenges spacefarers face. The ISS provides an excellent laboratory in which to conduct the required research. It is essential that the station be utilized to its fullest potential through cooperative studies and the sharing of equipment and instruments between the international partners. The sharing and application of the lessons learned from long-duration human spaceflight and analog research environments will not only lead to advances in technology and human knowledge to protect future space travelers but will also enhance life on Earth.

Organizing Partners Rice University’s Baker Institute for Public Policy The mission of the Baker Institute is to help bridge the gap between the theory and practice of public policy by drawing together experts from academia, government, media, business and nongovernmental organizations. By involving policymakers, scholars and students, the institute seeks to improve the debate on selected public policy issues and to make a difference in the formulation, implementation and evaluation of public policy, both domestic and international. The Baker Institute is an integral part of Rice University, one of the nation’s most distinguished institutions of higher education. The efforts of Baker Institute fellows and affiliated Rice faculty focus on several ongoing research projects, details of which can be found on the institute’s website, www.bakerinstitute.org.

Baylor College of Medicine Baylor College of Medicine is committed to being a national leader in advancing human health through the integration of patient care, research, education and community service. The college pursues this mission by promoting patient care of the highest standard, advancing basic and clinical biomedical research, sustaining educational excellence, and fostering public awareness of health and the prevention of disease. Since its founding in 1900, Baylor has grown into an internationally respected medical and research institution. Baylor offers patient care services through several of its Texas Medical Center affiliate hospitals and clinics, with more than 152,000 inpatient visits and 2.2 million outpatient visits annually. The college has more than 70 research and patient-care centers and units. More information can be found on the school’s website, www.bcm.edu. INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas

Participating Organizations Association of Air Medical Services (AAMS) University on Delhi, India Association of American Medical Colleges (AAMC) University of Pennsylvania Association of Space Explorers (ASE) University of Roma Tor Vergata Athena Global University of Southampton Bauman Moscow State Technical University University of Wollongong, Australia (Bauman MSTU) The University of Texas Health Science Center at Houston Baylor College of Medicine (BCM) (UTHSC) Boeing Space Exploration The University of Texas Medical Branch at Galveston Boise State University (UTMB) Canadian Space Agency (CSA) The University of Texas Southwestern Medical Center China Research and Training Center (ACC) at Dallas (UTSW) Commonwealth Scientific and Industrial Research Wyle Organisation (CSIRO) Gagarin Cosmonaut Research and Training Center (GCTC) German Aerospace Center (DLR) European Space Agency (ESA) Foundation for International Space Education (FISE) Harvard University Hawaii Space Exploration Analog & Simulation (HI-SEAS) Henry Ford Health System (HFHS) Indian Space Research Organization (ISRO) Institute for Biomedical Problems (IBMP) International Space School Educational Trust (ISSET) Japan Aerospace Exploration Agency (JAXA) Johns Hopkins School of Medicine King’s College London Lunar and Planetary Institute (LPI) Massachusetts Institute of Technology (MIT) The Methodist Hospital (TMH) Moscow State University The Museum of Flight National Aeronautics and Space Administration (NASA) National Institutes of Health (NIH) National Space Biomedical Research Institute (NSBRI) Rice University Rice University’s Baker Institute for Public Policy Russian Academy of Sciences (RAS) Russian Federal Space Agency () Swansea University Tietronix/Safetronix UK Space Agency Universities Space Research Association (USRA) University College London (UCL) University of Geneva University of Houston (UH) University of Maryland INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas

Conference Agenda Thursday, June 4

1800 Opening Reception BioScience Research Collaborative, Rice University

Friday, June 5

0800 Continental Breakfast

Welcome, Introductions and Opening Remarks 0830 The Honorable Edward P. Djerejian Director, Rice University’s Baker Institute for Public Policy George W.S. Abbey Senior Fellow in Space Policy, Rice University’s Baker Institute for Public Policy Bobby R. Alford Distinguished Service Professor, Baylor College of Medicine; and Chairman, National Space Biomedical Research Institute

Keynote Address Introduction: George W.S. Abbey, Baker Institute 0845 Neal F. Lane Senior Fellow in Science and Technology Policy, Baker Institute; and Malcolm Gillis University Professor, Rice University

Panel I — Russian Roadmap Introduction: Jeffrey Sutton, NSBRI 0915 Moderator: Igor Ushakov, IBMP Panelists Vadim Gushchin, IBMP , Cosmonaut Sergey Ryazansky, Cosmonaut Vladimir Sychev, IBMP Yuri Voronkov, IBMP Topics • Reducing risks for exploration missions • Enhancing human performance Discussion and Summation INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas

Panel II — U.S. Roadmap Introduction: William H. Gerstenmaier, NASA 1100 Moderator: Graham Scott, NSBRI Panelists Serena Aunon, Astronaut John Charles, NASA Joe Dervay, NASA Richard Linnehan, Astronaut Dava Newman, NASA Peter Norsk, NASA Bill Paloski, NASA Julia Robinson, NASA Topics • Major “red” risks for exploration missions • Actions needed to mitigate the exploration mission risks • The process for defining, cataloging and addressing the appropriate interventions for • Measuring progress on reducing the risk Discussion and Summation

Luncheon Introduction: Jeffrey Sutton, NSBRI 1230 Robert Robbins President and CEO, Texas Medical Center

Live Connection to the International Space Station Introduction: George W.S. Abbey, Baker Institute 1305 Astronaut Panelists Thomas P. Stafford, Astronaut Alexei A. Leonov, Cosmonaut Charles F. Bolden Jr., Astronaut INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas

Panel III — Collaborative Roadmap Introduction: George W.S. Abbey, Baker Institute 1345 Moderator: William H. Gerstenmaier, NASA Panelists Michael Barratt, Astronaut Joe Dervay, NASA Elena Fomina, IBMP Rupert Gerzer, DLR Perry Johnson-Green, CSA Inesa Kozlovskaya, IBMP Akika Matsumoto, JAXA Igor Ushakov, IBMP , JAXA Topics • Cooperative activities to reduce the risks of exploration missions and enhance human performance • Mitigate of crew time • Increase the number of subjects that are being studied Discussion and Summation

1600 Reception

Select pieces on display from the “Humans in Space” Youth Art Competition

The international Humans in Space Youth Art Competition encourages youth to “be inspired, creative and heard.” It asks them to think about the future of human spaceflight and to creatively communicate their ideas, and promises to make these ideas viewable worldwide. By including the next generation in the planning of the future, the competition aims to enhance their awareness, interest and support for human spaceflight and to allow their ideas to begin shaping the future now.

Dinner and Evening Address Introduction: Jeffrey Sutton, NSBRI 1730 Space Medicine Yesterday and Tomorrow (In Memory of Oleg Gazenko) Anatoly Grigoriev Vice President, RAS; Scientific Director, IBMP INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas

Saturday, June 6

0800 Continental Breakfast

Panel IV — One-Year Mission Introduction: Graham Scott, NSBRI 0830 Moderator: Inesa Kozlovskaya, IBMP Panelists Michael Barratt, Astronaut John Charles, NASA Vadim Gushchin, IBMP Craig Kundrot, NASA Vladimir Titov, Cosmonaut Evgenia Yarmanova, IBMP Topics • The science that should be planned for this mission • International agreements on the experimental complements planned for the mission • Subsequent flight research planned for both sexes • Possible future one-year and/or two-year studies Discussion and Summation

Panel V — Twin Studies Introduction: John Charles, NASA 0930 Moderator: Michael Barratt, Astronaut Panelists Serena Aunon, Astronaut Ludmila Buravkova, IBMP Craig Kundrot, NASA Christian Otto, LPI Yuri Voronkov, IBMP Topics • Research objectives and challenges of the Twin Study • Ethical considerations of sharing data with the scientific community • The application of personalized or precision medicine to mitigate the risks in human spaceflight • Follow-up OMICS-based studies that should be planned/initiated • The OMICS studies in space being accomplished by the various space-faring nations • The lessons and the results learned in the past from Twin Studies in the areas of medicine and biology Discussion and Summation INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas

Panel VI — Extra-Vehicular Activity (EVA) Introduction: George W.S. Abbey, Baker Institute 1030 Moderator: Leroy Chiao, Astronaut Panelists Chris Cassidy, Astronaut Eugene Cernan, Astronaut Alexei A. Leonov, Cosmonaut Sergey Ryazansky, Cosmonaut Thomas P. Stafford, Astronaut Topics • Experiences with early EVAs • Successes, problems and challenges with EVAs considering past and present experiences • Future EVA plans Discussion and Summation

Luncheon Introduction: Neal F. Lane, Baker Institute 1130 Update on the Alpha Magnetic Spectrometer Samuel C.C. Ting Nobel Laureate and Principal Investigator for the Alpha Magnetic Spectrometer

Panel VII — Radiation: Update to Research Advances Introduction: Jeffrey Sutton, NSBRI 1300 Moderator: Graham Scott, NSBRI Panelists Marjan Boerma, NSBRI Keith Cengel, NSBRI Bernard Rabin, University of Maryland Vladimir Sychev, IBMP Igor Ushakov, IBMP Topics • Increased risks with mission lengths • Mitigating acute and degenerative risks during the mission • Shielding for protection and countermeasures • Long-term radiation effects on brain performance Discussion and Summation INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas

Panel VIII — Education: STEM Advances Introduction: George W.S. Abbey, Baker Institute 1415 Moderators: Karl Doetsch, Athena Global; and Barbara Morgan, Astronaut Panelists Chris Barber, ISSET Ludmila Buravkova, IBMP Bonnie Dunbar, Astronaut Francisco Fusco, FISE Amanda Hackler, NSBRI Steve Mackwell, LPI Seth Margoles, The Museum of Flight Jancy McPhee, LPI Andrew Turnage, ASE Topics • Stimulating interest in science and engineering education • Benefits of an international educational program • Catalysts for creating young students’ interest in science and engineering • Benefits and opportunities for student exchange programs Discussion and Summation

Panel IX — Cooperative Use of Analogs Introduction: Graham Scott, NSBRI 1515 Moderators: , Astronaut Panelists Jay Buckey, Astronaut David Dinges, NSBRI Rupert Gerzer, DLR Vadim Gushchin, IBMP Inesa Kozlovskaya, IBMP Christian Otto, LPI Scott Parazynski, Astronaut Lori Ploutz-Snyder, LPI Rachel Seidler, NSBRI Topics • Experiences with remote expeditions — how can they be applied to human performance assessments • The need to have high-fidelity and realistic analogs to better simulate spaceflight • More international participation in analog studies Discussion and Summation INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas

Discussion Groups The discussion groups provide an opportunity for all participants to collaborate with a group leader on an assigned topic. Each group will be tasked with developing a written report on their topic, to be presented Sunday morning. Your group assignment can be found on your name tag. If you do not find a letter on your name tag, please check with our staff.

1615 Group A Cooperative Research Team Leader: William H. Gerstenmaier, NASA

Group B Cooperative Use of Analogs Team Leader: Graham Scott, NSBRI

Group C Education Team Leader: Karl Doetsch, Athena Global; and Barbara Morgan, Astronaut

Reception and Dinner Introduction: George W.S. Abbey, Baker Institute 1800 40th Anniversary of the Apollo-Soyuz Test Project (ASTP) and 50th Anniversary of the First Human EVA Major General Thomas P. Stafford Astronaut Major General Alexei A. Leonov Cosmonaut

Music by Rice University’s Shepherd School of Music Ensemble INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas

Sunday, June 7

0830 Continental Breakfast

Discussion Group Reports 0900 Group A Cooperative Research

Group B Cooperative Use of Analogs

Group C Education

Closing Remarks 1200 Bobby R. Alford Distinguished Service Professor, Baylor College of Medicine; and Chairman, National Space Biomedical Research Institute George W.S. Abbey Senior Fellow in Space Policy, Rice University’s Baker Institute for Public Policy INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas

HUMANS IN SPACE YOUTH ART COMPETITION Painting Reproductions The international Humans in Space Youth Art Competition encourages youth to "Be Inspired, Be Creative and Be Heard:' We ask them to think about the future of human space flight and to creatively communicate their ideas, and we promise to make these ideas viewable worldwide. By including the next generation in the planning of the future, the competition aims to enhance their awareness, interest and support for human spaceflight and to allow their ideas to begin shaping the future now.

www.lpi.usra.edu/humansinspaceart/

Cradle of the Cosmos Future City in Space What's Your Horizon Anastasia Pronina Man Wai Leung Mayisha Nakib 14-17 years old age range 16 years old 17 years old Russian Federation China United States

BEAM Base Exploration Aboard Mars Universe Championship Look at Our New World Emily Miedema and Abby Bull Asli Soyer Chi Yin Yu 12 years old 12 years old 13 years old Canada Turkey China

The Explorater Mission to Europa Moon Workers David Lane-Smith and Tom Miedema Oriana Menendez Albert Choi 11 years old 17 years old 10 years old Canada United States United States INTERNATIONAL SPACE MEDICINE SUMMIT 2015 June 4–7, 2015 • Rice University’s Baker Institute for Public Policy • Houston, Texas