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Xerox University Microfilms THE EFFECTS OF INHIBITION OF PROSTAGLANDIN SYNTHESIS ON THYROTROPIN SECRETION Item Type text; Dissertation-Reproduction (electronic) Authors Thompson, Martha Ellen, 1947- Publisher The University of Arizona. Rights Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. Download date 05/10/2021 07:19:06 Link to Item http://hdl.handle.net/10150/289460 INFORMATION TO USERS This material was produced from a microfilm copy of the original document. While the most advanced technological means to photograph and reproduce this document- have been used, the quality is heavily dependent upon the quality of the original submitted. The following explanation of techniques is provided to help you understand markings or patterns which may appear on this reproduction. 1.The sign or "target" for pages apparently lacking from the document photographed is "Missing Page(s)". If it was possible to obtain the missing page(s) or section, they are spliced into the film along with adjacent pages. This may have necessitated cutting thru an image and duplicating adjacent pages to insure you complete continuity. 2. When an image on the film is obliterated with a large round black mark, it is an indication that the photographer suspected that the copy may have moved during exposure and thus cause a blurred image. You will find a good image of the page in the adjacent frame. 3. When a map, drawing or chart, etc., was part of the material being photographed the photographer followed a definite method in "sectioning" the material. It is customary to begin photoing at the upper left hand corner of a large sheet and to continue photoing from left to right in equal sections with a small overlap. If necessary, sectioning is continued again — beginning below the first row and continuing on until complete. 4. The majority of users indicate that the textual content is of greatest value, however, a somewhat higher quality reproduction could be made from "photographs" if essential to the understanding of the dissertation. Silver prints of "photographs" may be ordered at additional charge by writing the Order Department, giving the catalog number, title, author and specific pages you wish reproduced. 5. PLEASE NOTE: Some pages may have indistinct print. Filmed as received. Xerox University Microfilms 300 North Zeeb Road Ann Arbor, Michigan 48106 76-29,342 THOMPSON, Martha Ellen, 1947- THE EFFECTS OF INHIBITION OF PROSTAGLANDIN SYNTHESIS ON THYROTROPIN SECRETION. The University of Arizona, Ph.D., 1976 Physiology Xerox University Microfilms, Ann Arbor, Michigan 48106 THE EFFECTS OF INHIBITION OF PROSTAGLANDIN SYNTHESIS ON THYROTROPIN SECRETION by Martha Ellen Thompson A Dissertation Submitted to the Faculty of the DEPARTMENT OF PHYSIOLOGY In Partial Fulfillment of the Requirements For the Degree of DOCTOR OF PHILOSOPHY In the Graduate College THE UNIVERSITY OF ARIZONA 19 7 6 THE UNIVERSITY OF ARIZONA GRADUATE COLLEGE I hereby recommend that this dissertation prepared under my direction by Martha Til 1 e>r> Thnmpwnn entitled THE EFFECTS OF INHIBITION OF PROSTAGLANDIN SYNTHESIS ON THYROTROPIN SECRETION be accepted as fulfilling the dissertation requirement of the degree of Doctor of Philosophy /9 /May ny<, Di5.5ferta.tion Director Date After inspection of the final copy of the dissertation, the following members of the Final Examination Committee concur in its approval and recommend its acceptance:» — /9 T J//<?/-?-<£ This approval and acceptance is contingent on the candidate's adequate performance and defense of this dissertation at the final oral examination. The inclusion of this sheet bound into the library copy of the dissertation is evidence of satisfactory performance at the final examination. STATEMENT BY AUTHOR This dissertation has been submitted in partial fulfillment of requirements for an advanced degree at The University of Arizona and is deposited in the University Library to be made available to bor­ rowers under rules of the Library. Brief quotations from this dissertation are allowable without special permission, provided that accurate acknowledgment of source is made. Requests for permission for extended quotation from or re­ production of this manuscript in whole or in part may be granted by the head of the major department or the Dean of the Graduate College when in his judgment the proposed use of the material is in the in­ terests of scholarship. In all other instances, however, permission must be obtained from the author. SIGNED: ACKNOWLEDGMENTS I wish to express my sincere appreciation to Dr. George Hedge who provided guidance and encouragement in both the research investi­ gation and preparation of this dissertation# I would also like to thank Dr. Gayle Orczyk, Merck Institute for Therapeutic Research, Rail­ way, New Jersey, 1975 and Dr. Delbert Fisher, Harbor General Hospital, Torrance, California, for their personal assistance in the radio­ immunoassay procedures in 1972. I also wish to thaiik Ms. Sherri Konen, Arizona Medical Center, Tucson, Arizona, Dr. Marvin Brown, Salk Insti­ tute, La Jolla, California, and the NIAMMDD Rat Pituitary Hormone Distribution Program for their invaluable assistance in the radio­ immunoassay procedures and data analysis. Appreciation is due to Drs. Douglas Stuart, Eldon Braun and Mark Haussler for their critical review of this dissertation. I am particularly indebted to Susan Dalby, Judy Cardoni and Nancy Hernden for their excellent technical assistance. iii TABLE OF CONTENTS Page LIST OF TABLES vi LIST OF ILLUSTRATIONS vii ABSTRACT x 1. INTRODUCTION 1 Hypothalamic Control of Anterior Pituitary Secretion . 1 Corticotropin-Releasing Factor (CRF) . 6 Thyrotropin-Releasing Hormone (TRH) 8 Luteinizing Hormone-Releasing Hormone (LHRH) ... 9 Growth Hormone-Releasing Factor (GRF) and Somatostatin (GIF) 12 Prolactin Release-Inhibiting Factor (PIF) and Prolactin-Releasing Factor (PRF) 13 Specificity of Releasing Factors for the Anterior Pituitary Hormones 15 Regulation of the Pituitary-Thyroid Axis 17 Hypothalamic Regulation of TSH Secretion .. • • 18 Environmental Stimuli for TSH Secretion ..... 20 Mechanism of Action of TRH 22 Thyroid Hormone Feedback Control of TSH Secretion 25 Circadian Rhythm of TSH Secretion 27 Mechanism of Action of TSH 27 Prostaglandins and the Hypothalamic-Pituitary- Endocrine Systems 28 Structure and Synthesis 29 Metabolism 31 Mechanism of Action 32 Systemic Effects of Prostaglandins 33 Aim of Present Study 39 2. MATERIALS AND METHODS **1 Animals and Care 4l Surgical Procedures 42 Chronic Indwelling Jugular Catheters 42 Thyroidectomy Procedure ............. Stereotaxic Microinjection Procedure 44 iv V TABLE OF CONTENTS—Continued Page Acute Cold Exposure . kk Pharmacological Preparations ............. kk Radioimmunoassay of Plasma TSH, T-j and T^ .. k$ Assessment of Thyroidal Activity ........... k? T^ and T* Half-life 47 Data Analysis .. 49 3. RESULTS 50 Measurement of Pituitary and Thyroid Responses to Various Stimuli 50 Thyrotropin Response 50 Thyroid Hormone Secretion ............. 63 Effect of Inhibition of Prostaglandin Synthesis on the Hypothalamic-Pituitary-Thyroid Axis •• 73 Systemic Indomethacin in Intact Rats . 73 Indomethacin or Aspirin Treatment in Thyroidec- tomized Rats .................. 8k Stereotaxic Microinjection Studies 99 DISCUSSION 103 Comparison of Plasma TSH, T^ and T^ Levels with Previously Reported Values ... ... 103 Measurement of Pituitary and Thyroid Response to Various Stimuli 105 TSH Response 105 Thyroid Hormone Secretion 109 Effects of Inhibition of Prostaglandin Synthesis on the Hypothalamic-Pituitary-Thyroid Axis 113 Systemic Indomethacin in Intact Rats ....... Ilk Indomethacin or Aspirin Treatment in Thyroidec- tomized Rats 118 Stereotaxic Microinjection Studies 122 Specificity of Indomethacin and Aspirin 123 Comparison of Results in This Study with Previous Studies Which Used Exogenous Prostaglandins ..... 126 Conclusions 127 LIST OF REFERENCES 129 LIST OF TABLES Table Page 1. Plasma thyrotropin (TSH) levels in response to ac *. ,* cold exposure with ether or pentobarbital anesthesia .. 51 2m Effect of acute cold exposure on plasma thyrotropin (TSH) concentrations in unanesthetized rats ...... 5^ 3. The effect of acute cold exposure on plasma Tj concen­ trations with ether or pentobarbital anesthesia .... 65 4. The effect of acute cold exposure on plasma Tif. concen­ trations with ether or pentobarbital anesthesia .... 66 5. Plasma levels in response to TRH with ether or pentobarbital anesthesia 69 6. Plasma T^ concentrations in response to thyrotropin (TSH) with ether or pentobarbital anesthesia ...*•• 72 7. Time schedule of the administration of drugs and sub­ sequent blood sampling for experiments in which intact rats were used 75 125 124 8. Disappearance rates for I-Tjj. and I-T^ following indomethacin treatment 82 9. Time schedules for surgery, drug (or vehicle) injec­ tions, T/j. replacement, and collection of blood samples for experiments in which TRH or thyroidectomy were used as stimuli to TSH secretion 85 10. Plasma TSH, T^, and T^ concentrations following TRH and aspirin (^5 mg/injection; Asp) or gelatin (Gel) treat­ ment in thyroidectomized rats receiving T^ replacement (3-0 /ig/100 g BW/day) 9^ vi LIST OF ILLUSTRATIONS Figure Page 1. Plasma thyrotropin (TSH) levels in response to acute cold exposure
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