DOCSLIB.ORG

Spindle-Cell Lipoma

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

PATHOLOGY CLINIC Spindle-cell lipoma Lester D.R.Thompson , MD Figure. A:At low power, only a scant amount offat (lower right) is notedin thisspindle-celllipoma. B:Adipocytes""" are seen between bundles of spindled cells with abundant collagen. This is the typical histologic appearance of a spindle-cell lipoma. C: Foca l fat is seen at theperiphery (left), while the spindle-cell population exhibits isolated atypical ormultinuclea tedcells.Mastcellsarealso present.D: Nofatis identifiedin this tumor,but thecharacteristic spindle-cellpopulation is seen with wire- or rope-like collagenfibers. Histolo gically, spindle-cell lipoma is a distinctive back, and sho ulders . Patients present with a painless, type of lipoma on a continuum with pleomorphic li­ m obile, subcuta ne ous ma ss. In rare cases, these tumors poma. It accounts for approxim ately 1.5% of all adi­ develop in other head and neck mucosal sites, such as pose tissue neopl asms. Men are affected significantly th e buccal fat pad. Spindle-cell lipomas grow as large more commonly th an women (9:1) at a mean age in the as 13 em (mea n: 3.5). Grossly, they resemble ordinary sixth decade. Th e vast majority of tumors are located lipomas, altho ugh th ey may be somew hat firmer, espe­ in the subcutaneo us tissue of the posterior neck, upper cially if the spindle-cell compo nent predominates. From the Depart ment of Patho logy, Woodland Hills Medical Center, Southern California Permanente Medical Group, Woodland Hills, Calif. 99 2 • www.entjournal.com ENT-Ear, Nose & Throat Journal · July 2009 PATHOLOG Y CLINIC Microscopically, these tumors are circumscribed, al­ chromosom es 13q and/o r 16q- Iosses that are consid­ though not truly encapsulated. They are composed of ered characteristic for this family of lipomas. mature fat cells mixed with bland spindle cells, hyper­ The differential diagnosis includes liposarcoma, chromatic round cells, and multinucleated giant cells. neurofibroma, and nuchal fibroma. Complete local ex­ The spindle cells are often arranged in parallel pha­ cision is cur ative. lanxes admixed with wire- or rope-like collagen fibers and a myxoid stroma (figure). Mast cells are frequently Suggested reading numerous , along with occasional lymphocytes and Enzinger FM, Harvey DA. Spindle cell lipoma. Cancer 1975;36(5): 1852-9. plasma cells.Mitotic figures are inconspicuous.Myxoid Fletcher CD, Martin-Bates E. Spindle cell lipoma: A clinicopathological areas may be seen.At the opposite end of the spectrum, study with some original observations. Histopathology 1987;1l a spindle-cell tumor may feature small, spindled, and (8):803- 17. Furlong MA, Fanburg-Smith IC, Childers EL. Lipoma of the oral round hyperchromatic cells and multinucleated giant and maxillofacial region: Site and subclassification of 125 cases. cells with radially arranged (floret-like) nuclei-that Oral Surg Oral Med Oral Pathol Ora l Radiol Endod 2004;98(4): 441-50. is, the features of a pleomorphic lipoma. By definition , Mentzel T, Fletcher CD. Lipomatous tumo urs of soft tissues:An update. lipoblasts are not present. Virchows Arch 1995;427(4):353-63. On immunohistochemistry, the spindle cells express Shmookler BM, Enzinger FM. Pleomorphic lipoma: A benign tumor simulating liposarcoma. A clinicopathologic analysis of 48 cases. CD34 and they are negative for 5-100 protein.Both Cancer 1981;47(1):126-33. spindle-cell and pleomorphic lipomas exhibit losses of WHY PAY RETAIL? Our surgical microscopes are meticulously reconditioned and guaranteed for two years, at a fraction of the cost of new. We have an extensive inventory of ZEISS and lEICA Systems Guaranteed 2 yearson ~II parts and'labor:'., F OR ALL YOUR PRESCOTT'S, NC. MI[:RO§I: O P E I\IEED§ 0s/t OU'~e\ RO. Box 609 • Monument, CO 80132 VV'ebs" (800) 438-3937 (719) 481-3353 • Fax (719) 488-2268 [email protected] 0 www.surgicalmicroscopes.com Volume 88, Number 7 www.entjournal.com • 99 3.
Recommended publications
  • A Rare Presentation of Benign Brenner Tumor of Ovary: a Case Report

    A Rare Presentation of Benign Brenner Tumor of Ovary: a Case Report

    International Journal of Reproduction, Contraception, Obstetrics and Gynecology Periasamy S et al. Int J Reprod Contracept Obstet Gynecol. 2018 Jul;7(7):2971-2974 www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789 DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20182920 Case Report A rare presentation of benign Brenner tumor of ovary: a case report Sumathi Periasamy1, Subha Sivagami Sengodan2*, Devipriya1, Anbarasi Pandian2 1Department of Surgery, 2Department of Obstetrics and Gynaecology, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India Received: 17 April 2018 Accepted: 23 May 2018 *Correspondence: Dr. Subha Sivagami Sengodan, E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Brenner tumors are rare ovarian tumors accounting for 2-3% of all ovarian neoplasms and about 2% of these tumors are borderline (proliferating) or malignant. These tumors are commonly seen in 4th-8th decades of life with a peak in late 40s and early 50s. Benign Brenner tumors are usually small, <2cm in diameter and often detected incidentally during surgery or on pathological examination. Authors report a case of a large, calcified benign Brenner tumor in a 55-year-old postmenopausal woman who presented with complaint of abdominal pain and mass in abdomen. Imaging revealed large complex solid cystic pelvic mass -peritoneal fibrosarcoma. She underwent laparotomy which revealed huge Brenner tumor weighing 9kg arising from left uterine cornual end extending up to epigastric region.
  • Soft Tissue Cytopathology: a Practical Approach Liron Pantanowitz, MD

    Soft Tissue Cytopathology: a Practical Approach Liron Pantanowitz, MD

    4/1/2020 Soft Tissue Cytopathology: A Practical Approach Liron Pantanowitz, MD Department of Pathology University of Pittsburgh Medical Center [email protected] What does the clinician want to know? • Is the lesion of mesenchymal origin or not? • Is it begin or malignant? • If it is malignant: – Is it a small round cell tumor & if so what type? – Is this soft tissue neoplasm of low or high‐grade? Practical diagnostic categories used in soft tissue cytopathology 1 4/1/2020 Practical approach to interpret FNA of soft tissue lesions involves: 1. Predominant cell type present 2. Background pattern recognition Cell Type Stroma • Lipomatous • Myxoid • Spindle cells • Other • Giant cells • Round cells • Epithelioid • Pleomorphic Lipomatous Spindle cell Small round cell Fibrolipoma Leiomyosarcoma Ewing sarcoma Myxoid Epithelioid Pleomorphic Myxoid sarcoma Clear cell sarcoma Pleomorphic sarcoma 2 4/1/2020 CASE #1 • 45yr Man • Thigh mass (fatty) • CNB with TP (DQ stain) DQ Mag 20x ALT –Floret cells 3 4/1/2020 Adipocytic Lesions • Lipoma ‐ most common soft tissue neoplasm • Liposarcoma ‐ most common adult soft tissue sarcoma • Benign features: – Large, univacuolated adipocytes of uniform size – Small, bland nuclei without atypia • Malignant features: – Lipoblasts, pleomorphic giant cells or round cells – Vascular myxoid stroma • Pitfalls: Lipophages & pseudo‐lipoblasts • Fat easily destroyed (oil globules) & lost with preparation Lipoma & Variants . Angiolipoma (prominent vessels) . Myolipoma (smooth muscle) . Angiomyolipoma (vessels + smooth muscle) . Myelolipoma (hematopoietic elements) . Chondroid lipoma (chondromyxoid matrix) . Spindle cell lipoma (CD34+ spindle cells) . Pleomorphic lipoma . Intramuscular lipoma Lipoma 4 4/1/2020 Angiolipoma Myelolipoma Lipoblasts • Typically multivacuolated • Can be monovacuolated • Hyperchromatic nuclei • Irregular (scalloped) nuclei • Nucleoli not typically seen 5 4/1/2020 WD liposarcoma Layfield et al.
  • Immunohistochemical and Electron Microscopic Findings in Benign Fibroepithelial Vaginal Polyps J Clin Pathol: First Published As 10.1136/Jcp.43.3.224 on 1 March 1990

    Immunohistochemical and Electron Microscopic Findings in Benign Fibroepithelial Vaginal Polyps J Clin Pathol: First Published As 10.1136/Jcp.43.3.224 on 1 March 1990

    224 J Clin Pathol 1990;43:224-229 Immunohistochemical and electron microscopic findings in benign fibroepithelial vaginal polyps J Clin Pathol: first published as 10.1136/jcp.43.3.224 on 1 March 1990. Downloaded from T P Rollason, P Byrne, A Williams Abstract LIGHT MICROSCOPY Eleven classic benign "fibroepithelial Sections were cut from routinely processed, polyps" of the vagina were examined paraffin wax embedded blocks at 4 gm and using a panel of immunocytochemical immunocytochemical techniques were agents. Two were also examined electron performed using a standard peroxidase- microscopically. In all cases the stellate antiperoxidase method.7 The antibodies used and multinucleate stromal cells were as follows: polyclonal rabbit characteristic of these lesions stained antimyoglobin (batch A324, Dako Ltd, High strongly for desmin, indicating muscle Wycombe, Buckinghamshire), monoclonal intermediate filament production. In anti-desmin (batch M724, Dako Ltd), mono- common with uterine fibroleiomyomata, clonal anti-epithelial membrane antigen (batch numerous mast cells were also often M613, Dako Ltd), monoclonal anti-vimentin seen. Myoglobin staining was negative. (batch M725, Dako Ltd), polyclonal rabbit Electron microscopical examination anti-cytokeratin (Bio-nuclear services, Read- confirmed that the stromal cells con- ing) and monoclonal anti cytokeratin NCL tained abundant thin filaments with focal 5D3 (batch M503, Bio-nuclear services). densities and also showed the ultrastruc- Mast cells were shown by a standard tural features usually associated with chloroacetate esterase method using pararo- myofibroblasts. saniline,8 which gave an intense red cyto- It is concluded that these tumours plasmic colouration, and by the routine would be better designated polypoid toluidine blue method. myofibroblastomas in view of the above An attempt was made to assess semiquan- findings.
  • Well-Differentiated Spindle Cell Liposarcoma

    Well-Differentiated Spindle Cell Liposarcoma

    Modern Pathology (2010) 23, 729–736 & 2010 USCAP, Inc. All rights reserved 0893-3952/10 $32.00 729 Well-differentiated spindle cell liposarcoma (‘atypical spindle cell lipomatous tumor’) does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases Thomas Mentzel1, Gabriele Palmedo1 and Cornelius Kuhnen2 1Dermatopathologie, Friedrichshafen, Germany and 2Institute of Pathology, Medical Center, Mu¨nster, Germany Well-differentiated spindle cell liposarcoma represents a rare atypical/low-grade malignant lipogenic neoplasm that has been regarded as a variant of atypical lipomatous tumor. However, well-differentiated spindle cell liposarcoma tends to occur in subcutaneous tissue of the extremities, the trunk, and the head and neck region, contains slightly atypical spindled tumor cells often staining positively for CD34, and lacks an amplification of MDM2 and/or CDK4 in most of the cases analyzed. We studied a series of well-differentiated spindle cell liposarcomas arising in two female and four male patients (age of the patients ranged from 59 to 85 years). The neoplasms arose on the shoulder, the chest wall, the thigh, the lower leg, the back of the hand, and in paratesticular location. The size of the neoplasms ranged from 1.5 to 10 cm (mean: 6.0 cm). All neoplasms were completely excised. The neoplasms were confined to the subcutis in three cases, and in three cases, an infiltration of skeletal muscle was seen. Histologically, the variably cellular neoplasms were composed of atypical lipogenic cells showing variations in size and shape, and spindled tumor cells with slightly enlarged, often hyperchromatic nuclei.
  • Appendix 4 WHO Classification of Soft Tissue Tumours17

    Appendix 4 WHO Classification of Soft Tissue Tumours17

    S3.02 The histological type and subtype of the tumour must be documented wherever possible. CS3.02a Accepting the limitations of sampling and with the use of diagnostic common sense, tumour type should be assigned according to the WHO system 17, wherever possible. (See Appendix 4 for full list). CS3.02b If precise tumour typing is not possible, generic descriptions to describe the tumour may be useful (eg myxoid, pleomorphic, spindle cell, round cell etc), together with the growth pattern (eg fascicular, sheet-like, storiform etc). (See G3.01). CS3.02c If the reporting pathologist is unfamiliar or lacks confidence with the myriad possible diagnoses, then at this point a decision to send the case away without delay for an expert opinion would be the most sensible option. Referral to the pathologist at the nearest Regional Sarcoma Service would be appropriate in the first instance. Further International Pathology Review may then be obtained by the treating Regional Sarcoma Multidisciplinary Team if required. Adequate review will require submission of full clinical and imaging information as well as histological sections and paraffin block material. Appendix 4 WHO classification of soft tissue tumours17 ADIPOCYTIC TUMOURS Benign Lipoma 8850/0* Lipomatosis 8850/0 Lipomatosis of nerve 8850/0 Lipoblastoma / Lipoblastomatosis 8881/0 Angiolipoma 8861/0 Myolipoma 8890/0 Chondroid lipoma 8862/0 Extrarenal angiomyolipoma 8860/0 Extra-adrenal myelolipoma 8870/0 Spindle cell/ 8857/0 Pleomorphic lipoma 8854/0 Hibernoma 8880/0 Intermediate (locally
  • Pleomorphic Lipoma: a Rare Tumor in the Retropharyngeal Space Pleomorphic Lipoma: a Rare Tumor in the Retropharyngeal Space

    Pleomorphic Lipoma: a Rare Tumor in the Retropharyngeal Space Pleomorphic Lipoma: a Rare Tumor in the Retropharyngeal Space

    AIJOC 10.5005/jp-journals-10003-1141 CASE REPORT Pleomorphic Lipoma: A Rare Tumor in the Retropharyngeal Space Pleomorphic Lipoma: A Rare Tumor in the Retropharyngeal Space Vidya Bhushan Rangappa, Raghavendra Suresh, Kapila Manikantan, AM Balasubramanya ABSTRACT well encapsulated, hypodense lesion in the retropharyngeal Lipomas are benign tumors arising from fat cells. Occurrence space extending into right parapharyngeal space pushing of lipoma in retropharyngeal space is very rare entity. To the larynx and pharynx to left and displacement of right great best of our knowledge, this is the second case of pleomorphic vessels laterally (Fig. 2). The lesion was seen extending lipoma being reported in the retropharyngeal space. They are from skull base to upper mediastinum. Fine needle aspiration usually asymptomatic until they are of large size. We report a case of a large pleomorphic lipoma in the retropharyngeal space, cytology (FNAC) of the lesion was consistent with features with emphasis on the clinical characters and histologic of lipoma. Surgically the mass was removed with a extended characteristics of the lesion. These tumors are best managed thyroidectomy incision extending from right mastoid tip surgically by a transcervical approach. down to left lateral part of the neck. Mass was dissected Keywords: Pleomorphic, Retropharyngeal space, Lipoma, from the surrounding structures completely with the capsule Benign, Neck swelling. (Figs 3 and 4). The mass was measuring 8 × 6 cm (Fig. 5). How to cite this article: Rangappa VB, Suresh R, Manikantan Histopathological examination showed characteristic K, Balasubramanya AM. Pleomorphic Lipoma: A Rare Tumor in 'floret' cells which are large hyperchromatic multinucleated the Retropharyngeal Space.
  • Spindle Cell Lipoma of the Anterior Triangle of the Neck

    Spindle Cell Lipoma of the Anterior Triangle of the Neck

    Braz J Otorhinolaryngol. 2011;77(3):401. CASE REPORT BJORL .org Spindle cell lipoma of the anterior triangle of the neck: a rare entity Smita Upadhyay1, Arpit Sharma2, Shashikant Mhashal3, Jyoti P Dabholkar4 Keywords: immunohistochemistry, lipoma, neck. INTRODUCTION involves the elderly males. Most common both of these have similar cytogenetics they locations involve the posterior neck, shoulder are considered as a single entity 5. Solitary lipomas are the most common and back however in our case the anterior It is important to differentiate SCL from soft tissue tumor. Lipomas include a gamut triangle of the neck were involved. liposarcoma. Liposarcoma are characterized of subtypes. Spindle cell lipoma (SCL) is a by more numerous spindle cells, presence of distinct entity accounting for about 1.5% of nuclear pleomorphism and MDM-2 amplifica- all lipomas1. The diagnosis of SCL is a his- tion1. Myxoid stroma can sometimes be seen tological one and careful study is required to in SCL when it mimics myxoid liposarcomas. differentiate it from the liposarcoma. However the superficial location and the circumscribed lesion helps differentiate SCL CASE REPORT from the latter. Also the vascular pattern, pleomorphism and mitotic activity should A 48 year old male reported with a be assessed6. The other differential diagnosis history of a left sided neck swelling since 2 includes dermatofibrosarcoma protuberans, years which was progressively increasing in mammary type solitary fibrous tumor and size. A 4x4 cm swelling was present in the an- myofibroblastoma. terior triangle of the neck which was firm and The treatment is surgical excision mobile. ENT examination and investigations and recurrences are extremely rare even with were unremarkable.
  • Fibro-Epithelial Polyp: Case Report with Literature Review

    Fibro-Epithelial Polyp: Case Report with Literature Review

    ISSN: 2456-8090 (online) CASE REPORT International Healthcare Research Journal 2017;1(7):14-17. DOI: 10.26440/IHRJ/01_07/116 QR CODE Fibro-Epithelial Polyp: Case Report with Literature Review RATNA SAMUDRAWAR 1, HEENA MAZHAR2, MUKESH KUMAR KASHYAP3, RUBI GUPTA4 A Oral fibroma is the most common benign soft tissue tumor caused due to continuous trauma from sharp cusp of teeth or faulty dental B restoration. It presents as sessile or occasionally pedunculated painless swelling which can be soft to firm in consistency. Its incidence occurs mostly during third to fifth decade and shows preference for female. Its occurrence corresponds with intraoral areas that are S prone to trauma such as the tongue, buccal mucosa and labial mucosa, lip, gingiva. Even with conservative surgical excision, the T lesion may recur until the source of continuous irritation persists. This article presents a case of large size oral fibroma on left alveolar R region associated with ulceration along with literature review. A C KEYWORDS: Benign Connective Tissue Tumor, Fibro-epithelial Polyp, Irritation Fibroma, Traumatic Fibroma, Focal Fibrous T Hyperplasia. K INTRODUCTION Fibroma of the oral mucosa is the most common complaint of growth in left lower back region of benign soft tissue tumor of the oral cavity derived the mouth since 4 months. History elicited that from fibrous connective tissues (CTs).1 Its the a solitary, painless growth had been observed pathogenesis lies in the fact that due to continues in his left mandibular molar region which was local trauma, a type of reactive hyperplasia of initially small in size and then it gradually fibrous tissue occurs.2 Thus, “Focal fibrous enlarged to present size of oval shape, well- hyperplasia” (FFH) term was suggested by Daley defined, pedunculated lesion.
  • Atypical Fibroxanthoma - Histological Diagnosis, Immunohistochemical Markers and Concepts of Therapy

    Atypical Fibroxanthoma - Histological Diagnosis, Immunohistochemical Markers and Concepts of Therapy

    ANTICANCER RESEARCH 35: 5717-5736 (2015) Review Atypical Fibroxanthoma - Histological Diagnosis, Immunohistochemical Markers and Concepts of Therapy MICHAEL KOCH1, ANNE J. FREUNDL2, ABBAS AGAIMY3, FRANKLIN KIESEWETTER2, JULIAN KÜNZEL4, IWONA CICHA1* and CHRISTOPH ALEXIOU1* 1Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Erlangen, Germany; 2Dermatology Clinic, 3Institute of Pathology, and 4ENT Department, University Hospital Mainz, Mainz, Germany Abstract. Background: Atypical fibroxanthoma (AFX) is an in 1962 (2). The name 'atypical fibroxanthoma' reflects the uncommon, rapidly growing cutaneous neoplasm of uncertain tumor composition, containing mainly xanthomatous-looking histogenesis. Thus far, there are no guidelines for diagnosis and cells and a varying proportion of fibrocytoid cells with therapy of this tumor. Patients and Methods: We included 18 variable, but usually marked cellular atypia (3). patients with 21 AFX, and 2,912 patients with a total of 2,939 According to previous reports, AFX chiefly occurs in the AFX cited in the literature between 1962 and 2014. Results: In sun-exposed head-and-neck area, especially in elderly males our cohort, excision with safety margin was performed in 100% (3). There are two disease peaks described: one within the 5th of primary tumors. Local recurrences were observed in 25% of to 7th decade of life and another one between the 7th and 8th primary tumors and parotid metastases in 5%. Ten-year disease- decade. The former disease peak is associated with lower specific survival was 100%. The literature research yielded 280 tumor frequency (21.8%) and tumors that do not necessarily relevant publications. Over 90% of the reported cases were manifest on skin areas exposed to sunlight (4).
  • Soft Tissue Sarcoma Classifications

    Soft Tissue Sarcoma Classifications

    Soft Tissue Sarcoma Classifications Contents: 1. Introduction 2. Summary of SSCRG’s decisions 3. Issue by issue summary of discussions A: List of codes to be included as Soft Tissue Sarcomas B: Full list of codes discussed with decisions C: Sarcomas of neither bone nor soft tissue D: Classifications by other organisations 1. Introduction We live in an age when it is increasingly important to have ‘key facts’ and ‘headline messages’. The national registry for bone and soft tissue sarcoma want to be able to produce high level factsheets for the general public with statements such as ‘There are 2000 soft tissue sarcomas annually in England’ or ‘Survival for soft tissue sarcomas is (eg) 75%’ It is not possible to write factsheets and data briefings like this, without a shared understanding from the SSCRG about which sarcomas we wish to include in our headline statistics. The registry accepts that soft tissue sarcomas are a very complex and heterogeneous group of cancers which do not easily reduce to headline figures. We will still strive to collect all data from cancer registries about anything that is ‘like a sarcoma’. We will also produce focussed data briefings on sites such as dermatofibrosarcomas and Kaposi’s sarcomas – the aim is not to forget any sites we exclude! The majority of soft tissue sarcomas have proved fairly uncontroversial in discussions with individual members of the SSCRG, but there were 7 particular issues it was necessary to make a group decision on. This paper records the decisions made and the rationale behind these decisions. 2. Summary of SSCRG’s decisions: Include all tumours with morphology codes as listed in Appendix A for any cancer site except C40 and C41 (bone).
  • The Role of Cytogenetics and Molecular Diagnostics in the Diagnosis of Soft-Tissue Tumors Julia a Bridge

    The Role of Cytogenetics and Molecular Diagnostics in the Diagnosis of Soft-Tissue Tumors Julia a Bridge

    Modern Pathology (2014) 27, S80–S97 S80 & 2014 USCAP, Inc All rights reserved 0893-3952/14 $32.00 The role of cytogenetics and molecular diagnostics in the diagnosis of soft-tissue tumors Julia A Bridge Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA Soft-tissue sarcomas are rare, comprising o1% of all cancer diagnoses. Yet the diversity of histological subtypes is impressive with 4100 benign and malignant soft-tissue tumor entities defined. Not infrequently, these neoplasms exhibit overlapping clinicopathologic features posing significant challenges in rendering a definitive diagnosis and optimal therapy. Advances in cytogenetic and molecular science have led to the discovery of genetic events in soft- tissue tumors that have not only enriched our understanding of the underlying biology of these neoplasms but have also proven to be powerful diagnostic adjuncts and/or indicators of molecular targeted therapy. In particular, many soft-tissue tumors are characterized by recurrent chromosomal rearrangements that produce specific gene fusions. For pathologists, identification of these fusions as well as other characteristic mutational alterations aids in precise subclassification. This review will address known recurrent or tumor-specific genetic events in soft-tissue tumors and discuss the molecular approaches commonly used in clinical practice to identify them. Emphasis is placed on the role of molecular pathology in the management of soft-tissue tumors. Familiarity with these genetic events
  • Pathology and Genetics of Tumours of Soft Tissue and Bone

    Pathology and Genetics of Tumours of Soft Tissue and Bone

    bb5_1.qxd 13.9.2006 14:05 Page 3 World Health Organization Classification of Tumours WHO OMS International Agency for Research on Cancer (IARC) Pathology and Genetics of Tumours of Soft Tissue and Bone Edited by Christopher D.M. Fletcher K. Krishnan Unni Fredrik Mertens IARCPress Lyon, 2002 bb5_1.qxd 13.9.2006 14:05 Page 4 World Health Organization Classification of Tumours Series Editors Paul Kleihues, M.D. Leslie H. Sobin, M.D. Pathology and Genetics of Tumours of Soft Tissue and Bone Editors Christopher D.M. Fletcher, M.D. K. Krishnan Unni, M.D. Fredrik Mertens, M.D. Coordinating Editor Wojciech Biernat, M.D. Layout Lauren A. Hunter Illustrations Lauren A. Hunter Georges Mollon Printed by LIPS 69009 Lyon, France Publisher IARCPress International Agency for Research on Cancer (IARC) 69008 Lyon, France bb5_1.qxd 13.9.2006 14:05 Page 5 This volume was produced in collaboration with the International Academy of Pathology (IAP) The WHO Classification of Tumours of Soft Tissue and Bone presented in this book reflects the views of a Working Group that convened for an Editorial and Consensus Conference in Lyon, France, April 24-28, 2002. Members of the Working Group are indicated in the List of Contributors on page 369. bb5_1.qxd 22.9.2006 9:03 Page 6 Published by IARC Press, International Agency for Research on Cancer, 150 cours Albert Thomas, F-69008 Lyon, France © International Agency for Research on Cancer, 2002, reprinted 2006 Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention.