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Immunohistochemical and Electron Microscopic Findings in Benign Fibroepithelial Vaginal Polyps J Clin Pathol: First Published As 10.1136/Jcp.43.3.224 on 1 March 1990

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Immunohistochemical and Electron Microscopic Findings in Benign Fibroepithelial Vaginal Polyps J Clin Pathol: First Published As 10.1136/Jcp.43.3.224 on 1 March 1990 224 J Clin Pathol 1990;43:224-229 Immunohistochemical and electron microscopic findings in benign fibroepithelial vaginal polyps J Clin Pathol: first published as 10.1136/jcp.43.3.224 on 1 March 1990. Downloaded from T P Rollason, P Byrne, A Williams Abstract LIGHT MICROSCOPY Eleven classic benign "fibroepithelial Sections were cut from routinely processed, polyps" of the vagina were examined paraffin wax embedded blocks at 4 gm and using a panel of immunocytochemical immunocytochemical techniques were agents. Two were also examined electron performed using a standard peroxidase- microscopically. In all cases the stellate antiperoxidase method.7 The antibodies used and multinucleate stromal cells were as follows: polyclonal rabbit characteristic of these lesions stained antimyoglobin (batch A324, Dako Ltd, High strongly for desmin, indicating muscle Wycombe, Buckinghamshire), monoclonal intermediate filament production. In anti-desmin (batch M724, Dako Ltd), mono- common with uterine fibroleiomyomata, clonal anti-epithelial membrane antigen (batch numerous mast cells were also often M613, Dako Ltd), monoclonal anti-vimentin seen. Myoglobin staining was negative. (batch M725, Dako Ltd), polyclonal rabbit Electron microscopical examination anti-cytokeratin (Bio-nuclear services, Read- confirmed that the stromal cells con- ing) and monoclonal anti cytokeratin NCL tained abundant thin filaments with focal 5D3 (batch M503, Bio-nuclear services). densities and also showed the ultrastruc- Mast cells were shown by a standard tural features usually associated with chloroacetate esterase method using pararo- myofibroblasts. saniline,8 which gave an intense red cyto- It is concluded that these tumours plasmic colouration, and by the routine would be better designated polypoid toluidine blue method. myofibroblastomas in view of the above An attempt was made to assess semiquan- findings. titatively the relative numbers of multinucleate and pleomorphic stromal cells and mast cells present by grading on a scale of 0- + + + . The presence or absence of a more cellular http://jcp.bmj.com/ Benign vaginal polyps (fibroepithelial polyps, subepithelial dense zone was assessed both on pseudosarcoma botryoides, benign sarcoma- routine haematoxylin and eosin staining and tous vaginal polyps) can be misdiagnosed on sections stained with anti-desmin and as malignant embryonal rhabdomyosarcomas anti-vimentin. All cases were classified as (sarcoma botryoides) though the difference predominantly myxoid, predominantly colla- generally in age at which these two tumours genous, or mixed (when both patterns were occur must make this an uncommon occur- seen in roughly similar proportions). The on October 1, 2021 by guest. Protected copyright. rence.' They have received scant attention in number of mitotic figures per 10 high power the literature and their putative origin from fields was assessed by randomly counting 10 fibroblasts has been generally accepted."X fields on three occasions and averaging the They are usually small and asymptomatic but result. For this purpose a wide field microscope some may present with a mass or bleeding.' was used with a x 10 eyepiece, with a x 63 dry Department of Pathology, University This immunohistochemical and electron objective, at a final magnification of x 630. of Birmingham microscopic study was performed in an attempt Medical School, to elucidate further the nature of these uncom- Edgbaston lesions. ELECTRON MICROSCOPY T P Rollason mon Blocks were taken from the two most recent Department of cases after routine fixation in neutral buffered Pathology, formalin, postfixed in one per cent osmium Birmingham Maternity Hospital tetroxide for one hour at room temperature, A Williams Methods dehydrated in graded alcohols, embedded in A systematic review of all vaginal polyps in the Department of Araldite and ultrathin sectioning performed. Obstetrics and files of the Birmingham and Midland Hospital After staining in uranyl acetate and lead citrate Gynaecology, Dudley for Women was performed for the years from the grids were viewed in a JEOL 100S electron Road Hospital, 1970 to 1988 inclusive. This review yielded 11 microscope at 80Kv. Birmingham of the P Byrne "classic" fibroepithelial polyps vagina occurring in 10 women aged between 31 and Correspondence to: Dr Terence P Rollason, 64. Clinical details were obtained by review of Results Department of Pathology, the case notes and contacting the The clinical details are shown in table 1. No The Medical School, hospital by University of Birmingham, patients' general practitioners. During the clear association was seen with parity, hormone Egbaston, Birmingham B15 years included in the review about 72 000 treatment etc, though interestingly one patient 2TJ, England. cases were also had uterine and ileal leiomyomata. No Accepted for publication general gynaecological surgical 12 October 1989 examined. evidence of tumour recurrence or metastasis Immunohistochemical and electron microscopicfindings in benignfibroepithelial vaginalpolyps 225 Table 1 Clinical details of investigated cases Follow up Case No Age Symptoms Associated pathology (months) Parity Site ofpolyp 1 48 Polyps catching clothes None 12 3 + 0 Right fornix and lower vagina J Clin Pathol: first published as 10.1136/jcp.43.3.224 on 1 March 1990. Downloaded from 2 41 Dyspareunia None 12 3 + 2 Posterior wall, near fourchette 3 54 Swelling and bleeding Leiomyomata of uterus 10 years previously 3 ? Mid-part, anterior wall 4 53 None Endometrial adenocarcinoma 120 1 + 0 Upper third, left side 5 52 None Leiomyomata of uterus and small bowel 132 2 + I Anterior wall, mid-third 6 51 None Leiomyomata of uterus 4 years previously 48 1 + 0 Anterior wall, lower third 7 56 None Breast carcinoma previously 24 1 + 0 ? 8 31 None None 120 0 + 0 Upper third, right side 9 57 Vaginal swelling None 6 0 + 0 Left fornix 10 64 Postmenopausal bleeding None 6 0 + 0 Left anterior vaginal wall Table 2 Histologicalfindings Size Mitotic rate Subepithelial Mast cell Pleomorphic Desmin Vimentin Case No Pattern (cm) (10 HPF) dense zone* infiltrate multinucleate cells staining staining 11 2 15 x 10 0 0 + ++ ++ ++ 12 1 20 x 15 0 0 ++ + + +++ ++ 2 1 10 x 05 0 2 + + ++ ++ 3 2 20 x 20 06 2 ++ + +++ +++ 4 1 14 x 08 0 2 ++ + +++ +++ 5 3 25 x 08 0 2 + +++ +++ +++ 6 1 15 x 08 0 1 ++ + ++ 7 1 16 x 07 0 2 +++ ++ ++ +++ 8 1 1-2max 0 2 +++ + +++ ++ 9 1 80 x 50 0 1 +++ ++ +++ +++ 10 2 20 x 15 0 1 +++ + +++ + Pattern: 1 = myxoid *0 = absent 2 = collagenous 1 = present on PAP and haematoxylin and eosin staining 3 = mixed 2 = present on PAP staining alone was seen in any patient during follow up. prominent than the "usual" stellate cells No patient later developed a second polyp. and was eosinophilic and slightly granular. The clinical symptoms were variable and Inflammation was not a striking feature in any inconsistent. of the cases, though this has been stated to be The overall light microscopical findings are seen in these tumours. Cross striations were not summarised in table 2. The background seen. stromal cells were spindled or stellate with fine The cellular pleomorphism classically des- collagen bundles between cells clearly defined cribed in the stromal cells in about 50% of cases against a pale background (figs 1 and 2). The was not, in its more pronounced form, apparent cytoplasm of the larger cells was more in any of our cases, and the pleomorphism that http://jcp.bmj.com/ X ° & A~~~~A Va i 40 on October 1, 2021 by guest. Protected copyright. ,~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~...... ~~~~~~~~~~~~~~~4, .~~~~~~~~..:~~~ ~~~~~~ ..... de i- S 0~~~~~. .a...r #1~~~~~~~~~~~~~~Y -~~~~~~~~~~~~~~~~~- A~~~~~~~~~~~~~~~ W, "A-a /. stroma.(Heaoyi anesi. q~~~- JK (* 'jr WAt FiueI acso Tpia per <eptheil&oy is5 that ofmxiMatr withmliulaecll,pol eie colgnuS solid.~V spndedstoml uls,an a -irllr cllgnu strma(aemtoyln ad osn. 226 Rollason, Byrne, Williams Figure 3 Multinucleate cells showing overlapping 40 Desmin and vimentin staining were almost nuclei against a f' ..I always moderately to intensely positive in most background ofspindle v.. or all of the tumour stromal cells (fig 4), with cells. (Haematoxylin and only one exception where vimentin staining eosin.) was only weakly positive; desmin positivity in J Clin Pathol: first published as 10.1136/jcp.43.3.224 on 1 March 1990. Downloaded from this case was, however, intense. Cytokeratin, myoglobin, and epithelial membrane antigen (EMA) staining were invariably absent in stromal cells. The epithelium of the polyps was entirely squamous and generally showed only slight W"' os:s.\t@.. kO=AC. simple hyperplastic changes; no intraepithelial ... v .;9 neoplasia or other clinically important ts *. pathology was seen. Slight parakeratosis was S..: ; C... ' evident in a few cases. The stroma ofthe polyps * * ... was not .: notable only for the loose myxoid *i E ; ..... 9# appearance in most cases, but also for the ^:ki profusion of small vessels seen. Only two cases had a predominantly collagenous stroma. The mitotic rate in the tumours was extremely low; only one case showed any stromal cell mitoses. None of the cases showed the subepithelial "cambium" layer or perivascular cellular sheaths typically associated with embryonal rhabdomyosarcoma, but a feature seen in f several cases on simple haematoxylin and eosin staining (fig 5), and evident in all but one case on both vimentin and desmin staining, was the presence of a more compact subepithelial zone which seemed to be both more collagenous
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