Soft Tissue Sarcoma Classifications
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Rare Case Botryoid Rhabdomyosarcomas of the Genital Tract
ISSN: 2581-5407 DOI: https://dx.doi.org/10.17352/gjct CLINICAL GROUP Received: 25 April, 2020 Case Report Accepted: 29 April, 2020 Published: 30 April, 2020 *Corresponding author: M Lahfaoui, Department Rare Case Botryoid of Pediatric Visceral and Urogenital Surgery, Oujda Children’s Hospital. Morocco, E-mail: Rhabdomyosarcomas of the https://www.peertechz.com Genital Tract. About a case in a 30-month-old child M Lahfaoui* and H Benhaddou Department of Pediatric Visceral and Urogenital Surgery, Oujda Children’s Hospital. Morocco Abstract Rhabdomyosarcomas are the most common soft tissue sarcomas developed in children under 15 years of age. The reported fi nding is a vaginal tumour developed in a 30-month-old granddaughter. This was a typical botryoid rhabdomyosarcoma that usually occurs in the hollow organs lined with mucous membrane. Rhabdomyosarcomas have multiple aspects that vary according to the degree of cellular differentiation. The majority of these tumours can be classifi ed into four histological categories: embryonic, botryoid, alveolar or pleomorphic. Treatment involves excisional surgery combined with radiotherapy and chemotherapy. The prognosis remains bleak despite therapeutic advances in recent years. Introduction Anatomopathological examination of the specimen showed that it was a polypoid (grape-like) tissue bordered Rhabdomyosarcomas are the most common soft tissue by a slightly hyperplastic squamous epithelium. Beneath sarcomas developed in children under 15 years of age. this epithelium, within a myxoid layer, a proliferation of These tumours respond to multidisciplinary management: disseminated tumour cells was observed with an inconspicuous conservative surgery (Figure1), multi-chemotherapy and cytoplasm, a hyperchromatic, rounded or elongated nucleus, radiotherapy. Although the prognosis is always dire, a sometimes presenting cytonuclear atypia with monstrosity signifi cant proportion of children treated in this way do not metastasize [1]. -
A Rare Presentation of Benign Brenner Tumor of Ovary: a Case Report
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Periasamy S et al. Int J Reprod Contracept Obstet Gynecol. 2018 Jul;7(7):2971-2974 www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789 DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20182920 Case Report A rare presentation of benign Brenner tumor of ovary: a case report Sumathi Periasamy1, Subha Sivagami Sengodan2*, Devipriya1, Anbarasi Pandian2 1Department of Surgery, 2Department of Obstetrics and Gynaecology, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India Received: 17 April 2018 Accepted: 23 May 2018 *Correspondence: Dr. Subha Sivagami Sengodan, E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Brenner tumors are rare ovarian tumors accounting for 2-3% of all ovarian neoplasms and about 2% of these tumors are borderline (proliferating) or malignant. These tumors are commonly seen in 4th-8th decades of life with a peak in late 40s and early 50s. Benign Brenner tumors are usually small, <2cm in diameter and often detected incidentally during surgery or on pathological examination. Authors report a case of a large, calcified benign Brenner tumor in a 55-year-old postmenopausal woman who presented with complaint of abdominal pain and mass in abdomen. Imaging revealed large complex solid cystic pelvic mass -peritoneal fibrosarcoma. She underwent laparotomy which revealed huge Brenner tumor weighing 9kg arising from left uterine cornual end extending up to epigastric region. -
Primary Mixed Myosarcoma of the Uterine Tube: a Case Report and Review of the Literature ALEXANDER S
Med. J. 258 CASE REPORT: MYOSAIRCOMAMYOSARCOMA OFUTERINEOF UTERINE TUBE Canad.Feb. 3, 1968, Ass.vol. 98 dans 1'cesophage superieur. Le plus petit malade REFERENCES chez qui une biopsie fut prelevee pesait 13 livres 1. CROSBY, W. H.: Amer. or. Dig. Dis., 8: 2, 1963. 2. CAREY, J. B., JR.: Gastroenterology, 46: 550, 1964. et 6tait age de 9 mois. 3. BECK, L T. et al.: Bull. Gastroint. EBndosc., 11: 15, 1965. We wish to thank 0. H. Kimbell, Ph.D., H. Robidoux- 4. MCDONALD, W. G.: Gastroenterology, 51: 390, 1966. 5. PARTIN, J. C. AND SCHUBERT, W. K: New Eng. J. Poirier, R.N., R.-M. Leblanc, R.N., D. Michaud, R.N., Med., 274: 94, 1966. and Marc Gigu6re, R.B.P., for their co-operation and 6. KUITUNEN, P. AND VISAKORPI, J. K.: Lancet, 1: 1276, active assistance. 1965. Primary Mixed Myosarcoma of the Uterine Tube: A Case Report and Review of the Literature ALEXANDER S. ULLMANN, M.D. and MAERIT B. KALLET, M.D., Detroit, Mich., U.S.A. SINCE primary malignant neoplasms of the uterine tube are so rare that no one indi- vidual or clinic has been able to study a large series of patients, the importance of reporting every case has often been emphasized.2-4 Although over 800 cases of primary carcinoma of the tube have been described in the liter- ature,4 up to 1956 only 30 authentic cases of primary sarcoma had been reported and to this number Abrams added another one.1' 8 Recently we had the opportunity to study a patient with primary sarcoma of the fallopian tube. -
Immunohistochemical and Electron Microscopic Findings in Benign Fibroepithelial Vaginal Polyps J Clin Pathol: First Published As 10.1136/Jcp.43.3.224 on 1 March 1990
224 J Clin Pathol 1990;43:224-229 Immunohistochemical and electron microscopic findings in benign fibroepithelial vaginal polyps J Clin Pathol: first published as 10.1136/jcp.43.3.224 on 1 March 1990. Downloaded from T P Rollason, P Byrne, A Williams Abstract LIGHT MICROSCOPY Eleven classic benign "fibroepithelial Sections were cut from routinely processed, polyps" of the vagina were examined paraffin wax embedded blocks at 4 gm and using a panel of immunocytochemical immunocytochemical techniques were agents. Two were also examined electron performed using a standard peroxidase- microscopically. In all cases the stellate antiperoxidase method.7 The antibodies used and multinucleate stromal cells were as follows: polyclonal rabbit characteristic of these lesions stained antimyoglobin (batch A324, Dako Ltd, High strongly for desmin, indicating muscle Wycombe, Buckinghamshire), monoclonal intermediate filament production. In anti-desmin (batch M724, Dako Ltd), mono- common with uterine fibroleiomyomata, clonal anti-epithelial membrane antigen (batch numerous mast cells were also often M613, Dako Ltd), monoclonal anti-vimentin seen. Myoglobin staining was negative. (batch M725, Dako Ltd), polyclonal rabbit Electron microscopical examination anti-cytokeratin (Bio-nuclear services, Read- confirmed that the stromal cells con- ing) and monoclonal anti cytokeratin NCL tained abundant thin filaments with focal 5D3 (batch M503, Bio-nuclear services). densities and also showed the ultrastruc- Mast cells were shown by a standard tural features usually associated with chloroacetate esterase method using pararo- myofibroblasts. saniline,8 which gave an intense red cyto- It is concluded that these tumours plasmic colouration, and by the routine would be better designated polypoid toluidine blue method. myofibroblastomas in view of the above An attempt was made to assess semiquan- findings. -
Uterine Carcinosarcoma Associated with Pelvic Radiotherapy for Sacral Chordoma: a Case Report
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Available online at www.sciencedirect.com Taiwanese Journal of Obstetrics & Gynecology 51 (2012) 89e92 www.tjog-online.com Case Report Uterine carcinosarcoma associated with pelvic radiotherapy for sacral chordoma: A case report Korhan Kahraman a,*, Fırat Ortac a, Duygu Kankaya b, Gulsah Aynaoglu a a Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey b Department of Pathology, Ankara University School of Medicine, Ankara, Turkey Accepted 28 December 2010 Abstract Objective: Postirradiation sarcoma of the female genital tract is rare, but a recognized event. Most reported cases have been associated with history of radiotherapy for various gynecologic conditions, particularly cancer of the uterine cervix and abnormal uterine bleeding. The occurrence of uterine sarcoma secondary to radiotherapy for a non-gynecologic tumor and, furthermore, this condition being simultaneous with the recurrence of primary tumor is unique. Case Report: A 67-year-old woman presented with a uterine mass which was diagnosed as a sarcoma by endometrial curettage and history of pelvic radiotherapy 23 years previously for sacral chordoma. Surgical staging procedure for uterine malignancy was performed. The final pathologic diagnosis was carcinosarcoma of the uterus. Conclusion: In uterine masses seen in patients with history of irradiation to the pelvic field, the probability of uterine sarcomas should always be kept in mind. These tumors may occur simultaneously with recurrence of primary tumor previously treated by adjuvant radiation therapy. Copyright Ó 2012, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC. -
Diagnostic Immunohistochemistry for Canine Cutaneous Round Cell Tumours — Retrospective Analysis of 60 Cases
FOLIA HISTOCHEMICA ORIGINAL PAPER ET CYTOBIOLOGICA Vol. 57, No. 3, 2019 pp. 146–154 Diagnostic immunohistochemistry for canine cutaneous round cell tumours — retrospective analysis of 60 cases Katarzyna Pazdzior-Czapula, Mateusz Mikiewicz, Michal Gesek, Cezary Zwolinski, Iwona Otrocka-Domagala Department of Pathological Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland Abstract Introduction. Canine cutaneous round cell tumours (CCRCTs) include various benign and malignant neoplastic processes. Due to their similar morphology, the diagnosis of CCRCTs based on histopathological examination alone can be challenging, often necessitating ancillary immunohistochemical (IHC) analysis. This study presents a retrospective analysis of CCRCTs. Materials and methods. This study includes 60 cases of CCRCTs, including 55 solitary and 5 multiple tumours, evaluated immunohistochemically using a basic antibody panel (MHCII, CD18, Iba1, CD3, CD79a, CD20 and mast cell tryptase) and, when appropriate, extended antibody panel (vimentin, desmin, a-SMA, S-100, melan-A and pan-keratin). Additionally, histochemical stainings (May-Grünwald-Giemsa and methyl green pyronine) were performed. Results. IHC analysis using a basic antibody panel revealed 27 cases of histiocytoma, one case of histiocytic sarcoma, 18 cases of cutaneous lymphoma of either T-cell (CD3+) or B-cell (CD79a+) origin, 5 cases of plas- macytoma, and 4 cases of mast cell tumours. The extended antibody panel revealed 2 cases of alveolar rhabdo- myosarcoma, 2 cases of amelanotic melanoma, and one case of glomus tumour. Conclusions. Both canine cutaneous histiocytoma and cutaneous lymphoma should be considered at the beginning of differential diagnosis for CCRCTs. While most poorly differentiated CCRCTs can be diagnosed immunohis- tochemically using 1–4 basic antibodies, some require a broad antibody panel, including mesenchymal, epithelial, myogenic, and melanocytic markers. -
The Health-Related Quality of Life of Sarcoma Patients and Survivors In
Cancers 2020, 12 S1 of S7 Supplementary Materials The Health-Related Quality of Life of Sarcoma Patients and Survivors in Germany—Cross-Sectional Results of A Nationwide Observational Study (PROSa) Martin Eichler, Leopold Hentschel, Stephan Richter, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Jens Jakob, Susanne Singer, Robert Grützmann, Stephen Fung, Eva Wardelmann, Karin Arndt, Vitali Heidt, Christine Hofbauer, Marius Fried, Verena I. Gaidzik, Karl Verpoort, Marit Ahrens, Jürgen Weitz, Klaus-Dieter Schaser, Martin Bornhäuser, Jochen Schmitt, Markus K. Schuler and the PROSa study group Includes Entities We included sarcomas according to the following WHO classification. - Fletcher CDM, World Health Organization, International Agency for Research on Cancer, editors. WHO classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC Press; 2013. 468 p. (World Health Organization classification of tumours). - Kurman RJ, International Agency for Research on Cancer, World Health Organization, editors. WHO classification of tumours of female reproductive organs. 4th ed. Lyon: International Agency for Research on Cancer; 2014. 307 p. (World Health Organization classification of tumours). - Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE. The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part B: Prostate and Bladder Tumours. Eur Urol. 2016 Jul;70(1):106–19. - World Health Organization, Swerdlow SH, International Agency for Research on Cancer, editors. WHO classification of tumours of haematopoietic and lymphoid tissues: [... reflects the views of a working group that convened for an Editorial and Consensus Conference at the International Agency for Research on Cancer (IARC), Lyon, October 25 - 27, 2007]. 4. ed. -
Misdiagnosed Infantile Rhabdomyofibrosarcoma: a Case Report
2766 ONCOLOGY LETTERS 12: 2766-2768, 2016 Misdiagnosed infantile rhabdomyofibrosarcoma: A case report TAO PAN1*, KEN CHEN1*, RUN-SONG JIANG2 and ZHENG‑YAN ZHAO2 Departments of 1General Surgery and 2Reconstructive Plastic Surgery, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China Received January 19, 2015; Accepted February 16, 2016 DOI: 10.3892/ol.2016.5032 Abstract. Infantile rhabdomyofibrosarcoma is a rare form of infantile fibrosarcoma has uniform, solidly‑packed spindle cells soft‑tissue tumor often associated with difficulties in diagnosis. arranged in a fascicular or herringbone pattern similar to the The disease is positioned intermediately between rhabdo- vascular pattern observed with hemangiopericytoma (4). Infan- myosarcoma and infantile fibrosarcoma in terms of clinical tile rhabdomyofibrosarcoma may be identified as childhood presentation, immunohistochemistry, behavior, morphology spindle‑cell sarcoma with a low degree of rhabdoid differentiation and ultrastructural features. Reports of rhabdomyofibrosarcoma and aggressive clinical behavior (5). Overlooking the diagnosis cases are limited in the literature. The present case describes a of infantile rhabdomyofibrosarcoma may increase the chances 26‑month‑old female who presented with a slowly progressive, of local recurrence or metastatic disease; therefore, aggressive soft‑tissue mass in the right chest wall. The mass was success- multimodality treatment is required for these patients (6). Reports fully treated with surgery. Using histopathology, the tumor was of rhabdomyofibrosarcoma cases are limited in the literature. diagnosed and classified as infantile rhabdomyofibrosarcoma. The present case report describes a 26‑month‑old patient who The patient has been followed‑up for 2 years and is currently presented with a slowly progressive, soft‑tissue mass in the right in good condition. -
Fibro-Epithelial Polyp: Case Report with Literature Review
ISSN: 2456-8090 (online) CASE REPORT International Healthcare Research Journal 2017;1(7):14-17. DOI: 10.26440/IHRJ/01_07/116 QR CODE Fibro-Epithelial Polyp: Case Report with Literature Review RATNA SAMUDRAWAR 1, HEENA MAZHAR2, MUKESH KUMAR KASHYAP3, RUBI GUPTA4 A Oral fibroma is the most common benign soft tissue tumor caused due to continuous trauma from sharp cusp of teeth or faulty dental B restoration. It presents as sessile or occasionally pedunculated painless swelling which can be soft to firm in consistency. Its incidence occurs mostly during third to fifth decade and shows preference for female. Its occurrence corresponds with intraoral areas that are S prone to trauma such as the tongue, buccal mucosa and labial mucosa, lip, gingiva. Even with conservative surgical excision, the T lesion may recur until the source of continuous irritation persists. This article presents a case of large size oral fibroma on left alveolar R region associated with ulceration along with literature review. A C KEYWORDS: Benign Connective Tissue Tumor, Fibro-epithelial Polyp, Irritation Fibroma, Traumatic Fibroma, Focal Fibrous T Hyperplasia. K INTRODUCTION Fibroma of the oral mucosa is the most common complaint of growth in left lower back region of benign soft tissue tumor of the oral cavity derived the mouth since 4 months. History elicited that from fibrous connective tissues (CTs).1 Its the a solitary, painless growth had been observed pathogenesis lies in the fact that due to continues in his left mandibular molar region which was local trauma, a type of reactive hyperplasia of initially small in size and then it gradually fibrous tissue occurs.2 Thus, “Focal fibrous enlarged to present size of oval shape, well- hyperplasia” (FFH) term was suggested by Daley defined, pedunculated lesion. -
Transcriptional Regulation of IGF-I Receptor Gene Expression by Novel Isoforms of the EWS-WT1 Fusion Protein
Oncogene (2002) 21, 1890 ± 1898 ã 2002 Nature Publishing Group All rights reserved 0950 ± 9232/02 $25.00 www.nature.com/onc Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein Ina Finkeltov1, Scott Kuhn3,4, Tova Glaser1, Gila Idelman1, John J Wright2, Charles T Roberts Jr3 and Haim Werner*,1 1Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978 Israel; 2Medicine Branch, Division of Clinical Science, National Cancer Institute, NIH, Bethesda, Maryland MD 20889, USA; 3Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon OR 97201, USA The EWS family of genes is involved in numerous Werner et al., 1994a). In addition to its central role in chromosomal translocations that are characteristic of a normal growth processes, the IGF-I-R plays a pivotal variety of sarcomas. A recently described member of this role in malignant transformation (Baserga et al., 1994; group is desmoplastic small round cell tumor (DSRCT), Grimberg and Cohen, 2000; Werner and LeRoith, which is characterized by a recurrent t(11;22)(p13;q12) 1996). The IGF-I-R is highly expressed in most tumors translocation that fuses the 5' exons of the EWS gene to and cancer cell lines, where it functions as a potent the 3' exons of the WT1 gene. The originally described antiapoptotic agent, conferring enhanced survival to chimera comprises exons 1 ± 7 of EWS and exons 8 ± 10 malignant cells (Resnico et al., 1995; Werner and of WT1. We have previously reported that the WT1 LeRoith, 1997). Transcription of the IGF-I-R gene is protein represses the expression of the IGF-I receptor negatively regulated by a number of tumor suppres- gene, whereas the EWS(1 ± 7)-WT1(8 ± 10) fusion protein sors, including p53, BRCA1 and WT1 (Maor et al., activates IGF-I receptor gene expression. -
Cellular Pseudosarcomatous Fibroepithelial Stromal Polyp of the Cervix: a Lesion Mimicking As Sarcoma
Advances in Cytology & Pathology Case Report Open Access Cellular pseudosarcomatous fibroepithelial stromal polyp of the cervix: a lesion mimicking as sarcoma Abstract Volume 3 Issue 1 - 2018 Introduction: Fibroepithelial stromal polyps (FESP) are infrequent mesenchymal Mahboob Hasan1 ,Ruquiya Afrose2 ,Mariya lesions found in vulvovaginal region but may also occur in the cervix, usually 1 seen in reproductive age group. FESP exhibiting bizarre cytomorphology, atypical Kamal 1Department of pathology, Aligarh Muslim University, India mitoses, or hypercellularity, raises the possibility of malignancy and continue to be 2Department of pathology, Uttar Pradesh University of Medical underrecognized. Sciences, India Case summary: We report a case of 45 years old, postmenopausal female presented with a large polypoidal cauliflower like growth with ulcerated surface, arising from Correspondence: Ruquiya Afrose, Assistant professor, Department of Pathology, Uttar Pradesh University of Medical exocervix. Cinical diagnosis of cervical malignancy was suggested. Histopathological Sciences, Saifai Etawah, 206301, India, Tel 9219716166, examination revealed a polypoidal tumor mass composed of cellular fibrovascular Email [email protected] stroma covered with stratified squamous epithelium. There are areas showing marked hypercellularity, bizarre cytomorphology and frequent mitotic figures (>10/10 HPF) Received: November 17, 2016 | Published: February 21, 2018 including atypical ones. Important morphologic clues to the diagnosis of FESP were its superficial -
About Soft Tissue Sarcoma Overview and Types
cancer.org | 1.800.227.2345 About Soft Tissue Sarcoma Overview and Types If you've been diagnosed with soft tissue sarcoma or are worried about it, you likely have a lot of questions. Learning some basics is a good place to start. ● What Is a Soft Tissue Sarcoma? Research and Statistics See the latest estimates for new cases of soft tissue sarcoma and deaths in the US and what research is currently being done. ● Key Statistics for Soft Tissue Sarcomas ● What's New in Soft Tissue Sarcoma Research? What Is a Soft Tissue Sarcoma? Cancer starts when cells start to grow out of control. Cells in nearly any part of the body can become cancer and can spread to other areas. To learn more about how cancers start and spread, see What Is Cancer?1 There are many types of soft tissue tumors, and not all of them are cancerous. Many benign tumors are found in soft tissues. The word benign means they're not cancer. These tumors can't spread to other parts of the body. Some soft tissue tumors behave 1 ____________________________________________________________________________________American Cancer Society cancer.org | 1.800.227.2345 in ways between a cancer and a non-cancer. These are called intermediate soft tissue tumors. When the word sarcoma is part of the name of a disease, it means the tumor is malignant (cancer).A sarcoma is a type of cancer that starts in tissues like bone or muscle. Bone and soft tissue sarcomas are the main types of sarcoma. Soft tissue sarcomas can develop in soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues.