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Soft Tissue Cytopathology: a Practical Approach Liron Pantanowitz, MD

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4/1/2020 Soft Tissue Cytopathology: A Practical Approach Liron Pantanowitz, MD Department of Pathology University of Pittsburgh Medical Center [email protected] What does the clinician want to know? • Is the lesion of mesenchymal origin or not? • Is it begin or malignant? • If it is malignant: – Is it a small round cell tumor & if so what type? – Is this soft tissue neoplasm of low or high‐grade? Practical diagnostic categories used in soft tissue cytopathology 1 4/1/2020 Practical approach to interpret FNA of soft tissue lesions involves: 1. Predominant cell type present 2. Background pattern recognition Cell Type Stroma • Lipomatous • Myxoid • Spindle cells • Other • Giant cells • Round cells • Epithelioid • Pleomorphic Lipomatous Spindle cell Small round cell Fibrolipoma Leiomyosarcoma Ewing sarcoma Myxoid Epithelioid Pleomorphic Myxoid sarcoma Clear cell sarcoma Pleomorphic sarcoma 2 4/1/2020 CASE #1 • 45yr Man • Thigh mass (fatty) • CNB with TP (DQ stain) DQ Mag 20x ALT –Floret cells 3 4/1/2020 Adipocytic Lesions • Lipoma ‐ most common soft tissue neoplasm • Liposarcoma ‐ most common adult soft tissue sarcoma • Benign features: – Large, univacuolated adipocytes of uniform size – Small, bland nuclei without atypia • Malignant features: – Lipoblasts, pleomorphic giant cells or round cells – Vascular myxoid stroma • Pitfalls: Lipophages & pseudo‐lipoblasts • Fat easily destroyed (oil globules) & lost with preparation Lipoma & Variants . Angiolipoma (prominent vessels) . Myolipoma (smooth muscle) . Angiomyolipoma (vessels + smooth muscle) . Myelolipoma (hematopoietic elements) . Chondroid lipoma (chondromyxoid matrix) . Spindle cell lipoma (CD34+ spindle cells) . Pleomorphic lipoma . Intramuscular lipoma Lipoma 4 4/1/2020 Angiolipoma Myelolipoma Lipoblasts • Typically multivacuolated • Can be monovacuolated • Hyperchromatic nuclei • Irregular (scalloped) nuclei • Nucleoli not typically seen 5 4/1/2020 WD liposarcoma Layfield et al. Musculoskeletal Cytohistology. Cambridge University Press. 2012 6 4/1/2020 Myxoid Liposarcoma Lipoblasts are often present Univacuolated Multivacuolated Myxoid Liposarcoma Characteristic branching (crow’s feet) vessels Myxoid liposarcoma 7 4/1/2020 Myxoid/Round Cell Liposarcoma Fleshy areas (arrows) indicate progression to high‐grade round cell sarcoma Hornick. Elsevier Saunders. 2013 Myxoid/Round Cell Liposarcoma Progression from myxoid to round cell liposarcoma Round Cell Component Myxoid Component Round cell liposarcoma 8 4/1/2020 CASE #2 • 88yr Female • Thigh mass • CNB with TP (DQ stain) LIVE VIEW Spindle Cell Lesions Nodular fasciitis (pseudosarcomas), schwannoma, Benign Entities neurofibroma, spindle cell lipoma/fibrolipoma, leiomyoma, fibromatosis, granulomatous inflammation, extra‐dural meningioma Low‐grade fibromyxoid sarcoma, DFSP, fibrosarcoma, Malignant Tumors leiomyosarcoma, synovial sarcoma, malignant peripheral nerve sheath tumors (MPNST), Kaposi sarcoma, some angiosarcomas, some liposarcomas, gastrointestinal stromal tumors (GIST), metastatic spindle cell carcinoma, spindle cell melanoma Hemangiopericytoma Pattern • Solitary fibrous tumor • Synovial sarcoma • Myopericytoma • Mesenchymal chondrosarcoma • Malignant peripheral nerve sheath tumor Branching dilated (staghorn) blood vessels 9 4/1/2020 SOLITARY FIBROUS TUMOR • Previously these were called Collagen “hemagiopericytoma” stroma • Pleural & occurs at other sites • Cellular to fibrous tumors • Hyper‐ and hypocellular areas • “Patternless” tumors • Dilated branching vessels • Immunohistochemistry: – STAT6+, CD34+ (90%), CD99+ Round (70%), EMA+ (30%), bcl‐2+ hyalinized (30%), and actin+ (20%) vessels Hornick. Elsevier Saunders. 2013 SOLITARY FIBROUS TUMORS (SFT) Cellular SFT Malignant SFT Monotonous cells & dilated vessels Nuclear atypia & mitoses Hornick. Elsevier Saunders. 2013 MYOFIBROBLASTIC PSEUDOSARCOMAS • Nodular fasciitis and variants: – Proliferative fasciitis & myositis – Intravascular fasciitis – Ischemic fasciitis (“atypical decubitis fibroplasia”) – Fasciitis ossificans • Pseudosarcomatous myofibrobalstic proliferation: – e.g. Post‐operative spindle cell nodule 10 4/1/2020 Nodular fasciitis Proliferative fasciitis Layfield et al. Musculoskeletal Cytohistology. Cambridge University Press. 2012 Synovial sarcoma 11 4/1/2020 NON‐MESENCHYMAL SPINDLE CELL NEOPLASMS • Spindle cell carcinoma • Spindle cell/desmoplastic melanoma • Spindle cell/desmoplastic mesothelioma • Others (metastatic gliosarcoma, extracranial meningioma, myeloid sarcoma, interdigitating dendritic cell sarcoma, mast cell neoplasms) UNCLASSIFIED SPINDLE CELL SARCOMA • 5‐10% of spindle cell sarcomas remain unclassifiable • Avoid calling these fibrosarcoma • This typically includes: – MPNST – Post‐radiation sarcomas • Myogenic differentiation implies a worse prognosis Hornick. Elsevier Saunders. 2013 CASE #3 • 22yr Male • Knee tumor • CNB with TP 12 4/1/2020 22M Knee tumor DQ 40x Diffuse type tenosynovial giant cell tumor (PVNS) Giant Cell Lesions • Predominance of multinucleated giant cells • Giant cells can be reactive or tumorous – Benign: Multiple, uniform, bland nuclei (e.g. foreign‐body giant cells) – Malignant: Hyperchromatic atypical nuclei (pleomorphic tumor cells) • Giant‐rich malignancies contain reactive osteoclastic cells • Megakaryocytes can be seen in myelolipoma & extramedullary hematopoeitic tumors 13 4/1/2020 Giant Cell Lesions Localized tenosynovial giant cell tumor (giant cell tumor of tendon sheath or nodular tenosynovitis), diffuse type Benign tenosynovial giant cell tumor (pigmented villonodular synovitis), myositis ossificans, nodular fasciitis Soft tissue giant cell tumor of low malignant potential, pleomorphic sarcomas (undifferentiated pleomorphic sarcoma or MFH), pleomorphic rhabdomyosarcoma, Malignant pleomorphic liposarcoma, dedifferentiated liposarcoma, pleomorphic leiomyosarcoma, giant cell‐rich osteosarcoma, myxofibrosarcoma), giant cell tumor of bone, metastatic giant cell carcinoma, melanoma, anaplastic large cell lymphoma, Hodgkin lymphoma (RS cells) Gout CASE #4 • 59yr Female • Thigh mass • CNB with TP (DQ stain) LIVE VIEW 14 4/1/2020 Small Round Cell Tumors Neuroblastoma, Ewing sarcoma/PNET, desmoplastic small round cell tumor (DSRCT), rhabdomyosarcoma, poorly Mesenchymal differentiated synovial sarcoma, extraskeletal mesenchymal chondrosarcoma, small cell osteosarcoma Small cell carcinoma, basaloid squamous cell carcinoma, Non‐Mesenchymal Merkel cell carcinoma, lymphoma/leukemia, germ cell tumor, melanoma with small cell morphology, hepatoblastoma, Wilm’s tumor, retinoblastoma Ewing sarcoma • Cellular isolated cells • 2‐3x small lymphocytes • Light (viable) cells • Dark (dying) cells • Nuclear molding • Tigroid background • Pseudorosettes Ewing sarcoma 15 4/1/2020 PNET Alveolar Rhabdomyosarcoma Alveolar Rhabdomyosarcoma MYOGENIN 16 4/1/2020 Melanoma with small cell features HMB45 Burkitt lymphoma CASE #5 • 38yr Man • Mid arm mass • FNA 17 4/1/2020 Arm mass (DQ) Cell block. Granular cell tumor Cell block. S100+ 18 4/1/2020 Epithelioid Cell Lesions • Rhabdomyoma • Granular cell tumor • Epithelioid sarcoma • Epithelioid variant of leiomyosarcoma • Malignant peripheral nerve sheath tumor • Epithelioid variant of angiosarcoma • Epithelioid hemangioendothelioma • Malignant extrarenal rhabdoid tumor • Pleomorphic rhabdomyosarcoma • Clear cell sarcoma of soft tissue • Alveolar soft part sarcoma • Metastases (melanoma, carcinoma, mesothelioma) • Hematolymphoid tumors (lymphoma, plasmacytoma, myeloid sarcoma) Epithelioid sarcoma Keratin+ & CD34+ Pleomorphic Lesions • There are several pleomorphic sarcomas (rhabdomyosarcoma, leiomyosarcoma, liposarcoma, chondrosarcoma) • Pleomorphic undifferentiated sarcoma (PLUS) – High‐grade (pleomorphic MFH) – Most common sarcoma >40 years – Hypercellular smears with necrosis – Marked nuclear atypia (anaplasia) – Giant cells (bizarre cells) – Numerous mitoses including atypical forms 19 4/1/2020 Rhabdomyosarcoma Undifferentiated sarcoma CASE #7 • 50yr Man • Knee cyst • FNA 50M Knee cyst. DQ Mag 20x 20 4/1/2020 Differential Diagnosis of Myxoid Lesions Hypocellular Myxoma, seroma, ganglion cyst, nodular fasciitis Benign Entities Nodular fasciitis, cellular myxoma, schwannoma, Cellular neurofibroma, benign mesenchymal tumors with Benign Entities myxoid change (fibrolipoma etc) Myxofibrosarcoma, myxoid liposarcoma, extraskeletal Malignant myxoid chrondrosarcoma, low‐grade fibromyxoid Entities sarcoma, sarcoma with myxoid features, chordoma and parachordoma, myoepithelial tumors of soft tissue, metastatic mucinous carcinomas Myxoid Stroma Gross Pathology (Myxoma) Histopathology (Myxoid Liposarcoma) Gelatinous FNA (cytopathology of myxoma) Appears granular Myxoid stroma Myxoid Tumors with Pleomorphism • Myxofibrosarcoma • Myoepithelial carcinoma • Myxoinflammatory fibroblastic sarcoma 21 4/1/2020 Myxofibrosarcoma (low grade) Myxofibrosarcoma (high grade) Examples of Myxoid Variants Dermatofibrosarcoma protuberans Solitary fibrous tumor Hornick. Elsevier Saunders. 2013 22 4/1/2020 23.
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  • Non-Wilms Renal Cell Tumors in Children

    Non-Wilms Renal Cell Tumors in Children

    PEDIATRIC UROLOGIC ONCOLOGY 0094-0143/00 $15.00 + .OO NON-WILMS’ RENAL TUMORS IN CHILDREN Bruce Broecker, MD Renal tumors other than Wilms’ tumor are tastases occur in 40% to 60% of patients with infrequent in childhood. Wilms’ tumors ac- clear cell sarcoma of the kidney, whereas they count for 6% to 7% of childhood cancer, are found in less than 2% of patients with whereas the remaining renal tumors account Wilms’ tumor.**,26 This distinct clinical behav- for less than l%.27The most common non- ior is one of the features that has led to its Wilms‘ tumors are clear cell sarcoma of the designation as a separate tumor. Other clini- kidney, rhabdoid tumor of the kidney (both cal features include a lack of association with formerly considered unfavorable Wilms’ tu- sporadic aniridia or hemihypertrophy. mor variants but now considered separate tu- Clear cell sarcoma of the kidney has not mors), renal cell carcinoma, mesoblastic been reported to occur bilaterally and is not nephroma, and multilocular cystic nephroma. associated with nephroblastomatosis. It has Collectively, these tumors account for less been reported in infancy and adulthood, but than 10% of the primary renal neoplasms in the peak incidence is between 3 and 5 years childhood. of age. It has an aggressive behavior that responds poorly to treatment with vincristine and actinomycin alone, leading to its original CLEAR CELL SARCOMA designation by Beckwith as an unfavorable histology pattern. The addition of doxorubi- Clear cell sarcoma of the kidney is cur- cin in aggressive chemotherapy regimens has rently considered a separate tumor distinct improved outcome.