Characteristic Analysis of Trigonelline Contained in Raphanus Sativus Cv
nutrients Article Characteristic Analysis of Trigonelline Contained in Raphanus sativus Cv. Sakurajima Daikon and Results from the First Trial Examining Its Vasodilator Properties in Humans Maho Sasaki 1, Yuri Nonoshita 2, Takashi Kajiya 3, Nobuhiko Atsuchi 3, Megumi Kido 4, Djong-Chi Chu 5, Lekh Raj Juneja 5, Yuji Minami 1,2,6 and Katsuko Kajiya 1,2,6,* 1 Graduate School of Agriculture, Forestry and Fisheries, Kagoshima University, Kagoshima 890-0065, Japan; k7451140@kadai.jp (M.S.); minami@chem.agri.kagoshima-u.ac.jp (Y.M.) 2 Department of Food Science & Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan; k2644727@kadai.jp 3 Department of Cardiology, Tenyoukai Central Hospital, Kagoshima 892-0822, Japan; t_kajiya@hotmail.com (T.K.); n-atsuchi@tenyoukai.org (N.A.) 4 Department of Human Life and Science, Kagoshima Women’s College, Kagoshima 890-8565, Japan; kido@jkajyo.ac.jp 5 ROHTO Pharmaceutical Co., Ltd., Osaka 544-8666, Japan; shu@rohto.co.jp (D.-C.C.); juneja@rohto.co.jp (L.R.J.) 6 Laboratory of Biochemistry & Nutritional Chemistry, The United Graduate School of Agricultural Sciences, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan * Correspondence: kajiya@chem.agri.kagoshima-u.ac.jp; Tel.: +81-99-285-8631 Received: 31 May 2020; Accepted: 22 June 2020; Published: 23 June 2020 Abstract: Vascular disease poses a major public health problem worldwide. Trigonelline isolated from Raphanus sativus cv. Sakurajima Daikon (Sakurajima radish) induces nitric oxide production from vascular endothelial cells and enhances vascular function. Here, we investigated the characteristics of trigonelline and its effects on endothelial function after consumption of Sakurajima radish by humans.
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