Suppression of Cancer Stemness p21- regulating mRNA and microRNA Signatures in Recurrent Ovarian Cancer Patient Samples

Item Type Journal Article

Authors Gallagher, Michael F;Heffron, Cynthia CBB;Laios, Alexandros;O'Toole, Sharon A;Ffrench, Brendan;Smyth, Paul C;Flavin, Richard J;Elbaruni, Salah A;Spillane, Cathy D;Martin, Cara M;Shelis, Orla M;O'Leary, John J

Citation Journal of Ovarian Research. 2012 Jan 19;5(1):2

Download date 01/10/2021 23:20:12

Link to Item http://hdl.handle.net/10147/212650

Find this and similar works at - http://www.lenus.ie/hse Note: Several have no entry for ' Symbol' or 'Gene Name' as they have not been characterised to date

202 Upregulated genes

ProbeID FC (diff/undiff) p value Gene_Symbol 341289 18.6056788624 0.001665 485170 10.1426044831 0.001088 409154 9.0287359182 0.000896 na 652688 8.867792484 0.000208 Olfr1450 588033 8.07364414781 0.001016 783155 7.74745554419 3.86E-05 Fgf5 721264 5.21772756106 0.001015 Dscam 422948 5.08262767899 0.002495 929310 5.0098691281 0.014696 Afp 312137 4.56141939571 0.000289 932248 4.54984711305 0.033262 Rbp4 441133 4.34579047246 0.003344 Slc28a2 476307 4.17380049091 0.014777 Bid3 391171 4.16629157347 0.004461 729395 4.10599555884 0.000174 Igfbp5 759808 4.10239795298 0.000309 Hist1h2ac 782315 4.03673355482 0.003529 5330408N05Rik 358837 3.79110822513 0.002291 Irs4 856242 3.77043245732 6.72E-06 316156 3.73605602537 0.016017 Tnfrsf18 396339 3.73356107439 0.001389 Tmprss2 437440 3.60374802582 0.001347 Hsd17b9 913230 3.45528593758 0.023757 Apoa2 372079 3.43327481605 0.016955 855571 3.29508990379 0.009278 744117 3.28855885615 0.002732 Rhbg 690253 3.27876576742 0.002464 Lnx1 589604 3.26416625524 0.038882 C230013L11Rik 643954 3.25222712475 0.003006 Dusp26 375429 3.1460226967 0.002382 Lamb3 811330 3.14553662819 0.008125 439174 3.14530597324 0.004766 659625 3.10208703883 0.040648 Theg 435760 3.08853964474 0.001297 1700027N10Rik 463597 3.07782281701 0.002621 357336 3.05691519713 0.02076 487588 3.03420908228 0.011475 344792 3.02445901838 0.003004 G0s2 666555 3.00280238509 0.00059 864310 2.98677165436 0.000642 Cthrc1 472226 2.9822984051 0.006597 789466 2.97130856376 0.012465 Prss12 915527 2.96284637289 0.027521 Clps 751623 2.94502457893 0.000351 772436 2.94221066067 7.90E-05 441590 2.9361888413 0.000369 Mal2 498825 2.93300755856 0.019462 Sec5l1 482117 2.89005256972 0.031114 852020 2.88913673131 0.032146 384320 2.88266992594 0.004587 749763 2.84308652484 0.04721 Gabrb3 829714 2.82597076042 0.004391 719012 2.82544708948 0.037377 Kng2 435392 2.79807878832 0.027857 699693 2.79270038196 0.006349 Mybpc2 578314 2.78291414454 0.000624 5730467H21Rik 930772 2.77299718302 0.001689 Slc16a13 352654 2.75647810574 0.047849 Dpep3 791865 2.74489720545 0.017442 Hist1h3f 464250 2.72996810134 0.007539 Rnf180 339024 2.71514230765 0.00158 Marveld3 834186 2.69156097001 0.026846 Fkbp6 853114 2.6747671313 0.004944 Kcnmb4 890132 2.67358928137 0.000182 na 546734 2.66247620068 0.020446 Prom2 399434 2.64977370306 0.005022 600412 2.63774169457 0.000409 E130203B14Rik 696550 2.62449222064 0.001079 Atf7ip2 593343 2.62444563577 0.000685 Arhgef3 359513 2.62011551944 0.010714 512117 2.61526010934 0.017748 439103 2.61448218283 9.09E-05 467523 2.60000507415 0.004698 Nkx3-1 885722 2.59833775256 0.000307 Rshl1 926231 2.59286307857 0.010917 503701 2.58939672626 0.016284 402567 2.57763685032 0.037634 Coch 365667 2.57198371132 0.042 Ntn4 658340 2.56425622364 0.020457 Cpvl 663785 2.56417636267 0.019016 Slc36a2 475705 2.56006860172 0.011984 2310045A20Rik 575758 2.55851922074 0.004551 393786 2.53647973682 0.042108 750975 2.53606660005 0.009494 Slc23a1 567279 2.52734888352 0.006174 Usp13 678556 2.50712985726 0.002549 848401 2.50708731376 0.000756 2810459M11Rik 728239 2.50180320442 0.000334 Gstm6 421816 2.49391065089 0.046343 Clec2e 890056 2.48952275134 0.034653 Pcanap6 302827 2.48573069851 0.044485 Fto 686468 2.4799464346 0.0038 891890 2.47008605534 0.027565 Magea8 733871 2.46250113173 0.016463 Zfp354b 765608 2.450592144 0.037322 854287 2.44762367371 0.006038 2210010L05Rik 505324 2.44324288993 0.003038 Maob 912184 2.44148033326 0.001956 Ttyh1 302054 2.43923373892 0.015935 Rapgef5 852049 2.42402785385 0.032517 Zfpn1a3 578285 2.41324312126 0.002041 Slc40a1 518663 2.40788461811 0.014087 Tmem41b 469652 2.38656224964 0.002834 Igsf1 504251 2.36784876329 3.80E-05 Adcy2 583301 2.3625222876 0.011436 752377 2.36201674651 0.015663 437388 2.35850924643 0.009758 469902 2.35835331446 0.033109 Lrrc3 588381 2.3549595481 0.030741 Alox15b 362206 2.35195518712 0.032508 Hist1h2ae 850476 2.35109600611 0.044969 na 557227 2.35049645359 0.0024 Dnahc11 718962 2.32927333145 0.01244 476172 2.32586745998 0.000692 4933402E13Rik 428487 2.31437654121 0.000507 Gnmt 558068 2.30984257309 0.00079 1110030H18Rik 742855 2.30961341576 0.034295 Zfp612 627721 2.3044054475 0.010394 Cpt1b 851904 2.30269481653 0.014548 464018 2.28851432727 0.045177 356847 2.28257183518 0.005877 Siglec5 904888 2.27101625072 0.004036 Tspan12 726308 2.2651880459 0.014553 4930429H24Rik 847962 2.26312030765 0.034202 636855 2.26195387455 0.001114 Sdsl 630009 2.2617308927 0.006848 2410118P20Rik 309042 2.25913001805 1.41E-05 Ctsh 365443 2.25470771993 0.000526 Cldn5 444993 2.25462937259 0.011052 Rab17 712936 2.24795521237 0.040285 Fgg 922534 2.24755533207 0.000113 Rassf6 825337 2.2431217124 0.006779 Lgi2 901716 2.24302512487 5.63E-05 Magea5 734299 2.23914435817 0.004765 na 925379 2.23562457232 0.022222 Akr1c13 919185 2.23235398204 3.80E-05 Tex12 729766 2.2307955898 0.010342 A030007D23Rik 868033 2.22927162845 8.14E-05 Olfm1 791213 2.22689408132 0.013178 E130115E03Rik 929804 2.22572590071 0.012438 Hsf2 761289 2.21774104397 0.000266 Sp8 629101 2.21270765197 0.013927 660865 2.19925835401 0.006201 2510049J12Rik 881510 2.19884127715 0.002952 4632411J06Rik 509729 2.19730378816 0.021886 612894 2.19016667524 0.000124 Ugt2b34 360587 2.18817139921 0.001062 676503 2.18732602199 0.027 895392 2.185759269 0.045317 411743 2.18532798903 0.011156 360072 2.18375499617 3.90E-06 AU040377 452328 2.18218385046 1.81E-05 Smpdl3a 370481 2.17940390408 0.020588 772549 2.17873245311 0.02432 902496 2.17733311761 0.035239 Cited1 448995 2.17595062006 0.005998 635689 2.17259678667 0.002801 Cct6b 523449 2.16381822728 0.036242 2810457I06Rik 315206 2.15981117138 0.013999 905421 2.15255652258 0.039734 5730559C18Rik 718886 2.15170625511 0.035213 C2 366145 2.15002931842 0.002668 6430537H07Rik 689441 2.14781925778 0.015769 LOC434197 490562 2.14189095571 0.034337 D14Ertd581e 912408 2.14094516968 0.001683 Gpx6 425404 2.13140127903 0.007522 D330012F22Rik 362896 2.12842234276 9.62E-05 Pdzk1 712844 2.12325329081 0.02888 Daf1 548509 2.12275804537 0.044085 Idua 829280 2.12144173925 2.60E-05 Prkcb1 672340 2.11853715528 0.036734 E130319B15Rik 382361 2.11839360787 0.0136 Nans 913451 2.11659745694 0.006603 Adssl1 361788 2.11643977181 0.000889 928493 2.11104502311 0.034293 Rgl3 579693 2.11015353378 0.000191 1700029J07Rik 528112 2.09950276965 0.01436 Plxdc2 651638 2.09620969495 0.031643 756314 2.09454758726 0.03974 Hira 855303 2.09291476923 0.007002 334928 2.09164057712 0.01141 Mmp15 692146 2.08605307878 0.016047 4922504H04Rik 764179 2.08072629668 0.026639 Crym 684703 2.07298984122 0.004079 Brsk2 383711 2.07183827259 0.005754 Pla1a 524957 2.069389009 0.002405 Anxa13 659628 2.06746123656 0.04066 Ahi1 687842 2.06673820638 0.023241 4930521I23Rik 482541 2.06232428099 1.93E-05 Slc35b4 560089 2.05979310542 0.010604 Shd 920968 2.05506689189 0.010824 H2-Eb1 529985 2.05367924585 0.027595 578271 2.04556459204 0.003288 Marveld2 770752 2.04393084492 6.03E-05 Nudt11 888362 2.04327036373 0.005208 736667 2.04264976504 0.014121 Nkd2 339692 2.03731214004 0.011121 Srrp 707662 2.03616105073 0.004863 Rnf144 548735 2.0248754998 0.022662 Leprel1 465508 2.01456682711 0.008433 Hebp2 676829 2.00828864251 0.018949 1700020N01Rik 353919 2.00688442611 0.044768 Mjd : Several genes have no entry for 'Gene Symbol' or 'Gene Name' as they have not been characterised to date

522 Downregulated genes

Gene_Name ProbeID FC (diff/undiff) 516139 -18.1915620938 528270 -14.9702171786 similar to putative pheromone receptor 442062 -13.6203817823 olfactory receptor 1450 314636 -13.0602128124 835755 -11.4022105946 fibroblast growth factor 5 514035 -11.2728466027 Down syndrome cell adhesion molecule 320172 -11.2669445041 615794 -10.4714093155 alpha fetoprotein 464719 -10.2050632551 651207 -9.87857231369 retinol binding 4, plasma 705206 -9.85167628171 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 871589 -9.81452785702 BH3 interacting (with BCL2 family) domain, apoptosis agonist 610341 -9.73346976972 915023 -9.57009385394 insulin-like growth factor binding protein 5 908253 -9.54639073676 histone 1, H2ac 597545 -9.16194992081 RIKEN cDNA 5330408N05 gene 468180 -9.03530950611 insulin receptor substrate 4 806675 -8.57769481242 429472 -8.56893367413 tumor necrosis factor receptor superfamily, member 18 927108 -8.41009037603 transmembrane protease, serine 2 661148 -8.38234404655 hydroxysteroid (17-beta) dehydrogenase 9 349030 -8.23370224344 apolipoprotein A-II 763310 -8.12878420198 812797 -8.09629126336 392370 -8.0922693843 Rhesus blood group-associated B glycoprotein 420519 -8.04733292558 ligand of numb-protein X 1 379058 -7.79437623663 RIKEN cDNA C230013L11 gene 313421 -7.71496135381 dual specificity phosphatase 26 (putative) 905599 -7.69145013744 laminin, beta 3 320467 -7.61148412382 398259 -7.53945417954 567727 -7.5246504835 testicular haploid expressed gene 672891 -7.31907280531 RIKEN cDNA 1700027N10 gene 906238 -7.2884594543 525670 -7.2828840323 558496 -7.25330387573 828621 -7.00332302989 G0/G1 switch gene 2 732899 -6.95021033909 672611 -6.91808908895 collagen triple helix repeat containing 1 428531 -6.87111171552 855041 -6.83216597818 protease, serine, 12 neurotrypsin (motopsin) 678861 -6.78046899891 colipase, pancreatic 761455 -6.76659140344 323549 -6.72467071126 585230 -6.64229670167 mal, T-cell differentiation protein 2 916662 -6.58762252096 SEC5-like 1 (S. cerevisiae) 409948 -6.5671508094 837469 -6.53795128047 850619 -6.50742548001 847553 -6.49590534751 gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3 638728 -6.45969158338 503177 -6.450328993 kininogen 2 644831 -6.10127207253 432944 -6.07028564893 myosin binding protein C, fast-type 454874 -6.06585159388 RIKEN cDNA 5730467H21 gene 343697 -6.06022182717 solute carrier family 16 (monocarboxylic acid transporters), member 13 419016 -5.96569249405 dipeptidase 3 926700 -5.933266825 histone 1, H3f 403505 -5.9184333354 ring finger protein 180 707425 -5.86979614396 MARVEL (membrane-associating) domain containing 3 446807 -5.78239006703 FK506 binding protein 6 924172 -5.63748969993 potassium large conductance calcium-activated channel, subfamily M, beta membe 920312 -5.61929709668 gene model 364, (NCBI) 932445 -5.60063581203 prominin 2 889958 -5.58311513206 332950 -5.58147615889 RIKEN cDNA E130203B14 gene 504226 -5.51924297174 activating transcription factor 7 interacting protein 2 630180 -5.47436156512 Rho guanine nucleotide exchange factor (GEF) 3 830241 -5.45131347203 627974 -5.42890461295 299973 -5.35022917164 747669 -5.32203428597 NK-3 transcription factor, locus 1 (Drosophila) 309034 -5.31945466248 radial spokehead-like 1 917511 -5.28467290506 353467 -5.21902935948 585421 -5.20693567015 coagulation factor C homolog (Limulus polyphemus) 928178 -5.19524456107 netrin 4 717247 -5.17798245536 carboxypeptidase, vitellogenic-like 905957 -5.16386221622 solute carrier family 36 (proton/amino acid symporter), member 2 916013 -5.13758154275 RIKEN cDNA 2310045A20 gene 915324 -5.13206173996 498118 -5.12711862935 378046 -5.11620815418 solute carrier family 23 (nucleobase transporters), member 1 373880 -5.1022053236 ubiquitin specific protease 13 (isopeptidase T-3) 533911 -5.08496340321 430674 -5.06725249568 RIKEN cDNA 2810459M11 gene 926361 -5.046440536 glutathione S-, mu 6 555944 -5.04138187659 C-type lectin domain family 2, member e 818736 -5.01151237934 prostate cancer associated protein 6 761124 -4.99114519063 fatso 474109 -4.98504781378 368451 -4.98424074868 melanoma antigen, family A, 8 401199 -4.93909873828 zinc finger protein 354B 828686 -4.93110487781 768070 -4.90907909251 RIKEN cDNA 2210010L05 gene 915817 -4.87103557054 monoamine oxidase B 874907 -4.86536973298 tweety homolog 1 (Drosophila) 411684 -4.86404932924 Rap guanine nucleotide exchange factor (GEF) 5 704669 -4.84117206386 zinc finger protein, subfamily 1A, 3 (Aiolos) 629949 -4.8346606399 solute carrier family 40 (iron-regulated transporter), member 1 791712 -4.82584639119 transmembrane protein 41B 378167 -4.74003658868 immunoglobulin superfamily, member 1 642750 -4.72465580074 adenylate cyclase 2 724965 -4.7206932686 733846 -4.71556474954 907844 -4.67093447032 703716 -4.66841940831 leucine rich repeat containing 3 576449 -4.64547882832 arachidonate 15-lipoxygenase, second type 796510 -4.6328086441 histone 1, H2ae 583928 -4.62819119813 hypothetical gene supported by AK082312 326734 -4.61723777957 dynein, axonemal, heavy chain 11 549284 -4.58562270677 828524 -4.51367903317 RIKEN cDNA 4933402E13 gene 920493 -4.49292691327 glycine N-methyltransferase 778341 -4.46497664131 RIKEN cDNA 1110030H18 gene 429729 -4.44105951267 zinc finger protein 612 511891 -4.43718020354 carnitine palmitoyltransferase 1b, muscle 920823 -4.42823361872 577209 -4.41844475265 930739 -4.41442013073 sialic acid binding Ig-like lectin 5 630673 -4.38780482809 tetraspanin 12 911976 -4.3746220439 RIKEN cDNA 4930429H24 gene 921015 -4.37345510616 411501 -4.3726220056 serine dehydratase-like 882942 -4.32427823009 RIKEN cDNA 2410118P20 gene 317785 -4.31685641652 cathepsin H 738350 -4.30301134527 claudin 5 381353 -4.29914962433 RAB17, member RAS oncogene family 923718 -4.27741343419 fibrinogen, gamma polypeptide 916048 -4.24795806854 Ras association (RalGDS/AF-6) domain family 6 907530 -4.21767867325 leucine-rich repeat LGI family, member 2 711228 -4.20738843781 melanoma antigen, family A, 5 356107 -4.20053659348 gene model 66, (NCBI) 847068 -4.18776404124 aldo-keto reductase family 1, member C13 700052 -4.13221667116 testis expressed gene 12 636139 -4.11412094205 RIKEN cDNA A030007D23 gene 347178 -4.11070492744 olfactomedin 1 322853 -4.08710721448 RIKEN cDNA E130115E03 gene 721190 -4.06303917136 heat shock factor 2 684806 -4.05867389147 trans-acting transcription factor 8 366836 -4.05772011565 347591 -4.04503724817 RIKEN cDNA 2510049J12 gene 922230 -4.0354975237 RIKEN cDNA 4632411J06 gene 811401 -4.0285035434 390970 -4.01602283725 UDP glucuronosyltransferase 2 family, polypeptide B34 865102 -4.01346173662 334281 -4.01114380306 711417 -4.01010508435 429467 -4.00997913538 931100 -3.99083583404 expressed sequence AU040377 932668 -3.96886555589 sphingomyelin phosphodiesterase, acid-like 3A 532728 -3.96130057923 473358 -3.95416391803 489417 -3.92810262153 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 690619 -3.92773397819 580280 -3.89923679359 chaperonin subunit 6b (zeta) 299883 -3.8939796702 RIKEN cDNA 2810457I06 gene 673664 -3.87109284108 914228 -3.85829181336 RIKEN cDNA 5730559C18 gene 704507 -3.81810104088 complement component 2 (within H-2S) 532474 -3.77760030546 RIKEN cDNA 6430537H07 gene 921450 -3.76857933903 similar to hypothetical protein FLJ39743 605866 -3.75791735474 DNA segment, Chr 14, ERATO Doi 581, expressed 817276 -3.75540488278 glutathione peroxidase 6 377670 -3.74925444768 RIKEN cDNA D330012F22 gene 607896 -3.74893712764 PDZ domain containing 1 805243 -3.74753628411 decay accelerating factor 1 884314 -3.74554578437 iduronidase, alpha-L- 501357 -3.73992185782 protein kinase C, beta 1 460343 -3.72166280988 RIKEN cDNA E130319B15 gene 436590 -3.71688495122 N-acetylneuraminic acid synthase (sialic acid synthase) 489776 -3.71100985975 adenylosuccinate synthetase like 1 777187 -3.70937165865 311389 -3.68760160375 ral guanine nucleotide dissociation stimulator-like 3 888038 -3.68175605121 RIKEN cDNA 1700029J07 gene 449085 -3.67406832961 plexin domain containing 2 839811 -3.66852958727 457936 -3.66831612315 histone cell cycle regulation defective homolog A (S. cerevisiae) 932742 -3.66369862137 725464 -3.63266621697 matrix metalloproteinase 15 836970 -3.61253411494 RIKEN cDNA 4922504H04 gene 865072 -3.59492836086 crystallin, mu 604623 -3.59179112563 BR serine/threonine kinase 2 464308 -3.5797452046 phospholipase A1 member A 486267 -3.56781664677 annexin A13 818677 -3.5545415169 Abelson helper integration site 660078 -3.54788039682 RIKEN cDNA 4930521I23 gene 397812 -3.53552291952 solute carrier family 35, member B4 806717 -3.53260494724 src homology 2 domain-containing transforming protein D 630644 -3.52654577673 histocompatibility 2, class II antigen E beta 341853 -3.50762088218 388904 -3.50314281991 MARVEL (membrane-associating) domain containing 2 916978 -3.49254215257 nudix (nucleoside diphosphate linked moiety X)-type motif 11 332683 -3.48398116424 917291 -3.47424472955 naked cuticle 2 homolog (Drosophila) 866931 -3.43994196699 serine-arginine repressor protein 315249 -3.43367082939 ring finger protein 144 502640 -3.4212724183 leprecan-like 1 921849 -3.41804426327 heme binding protein 2 435831 -3.41544250472 RIKEN cDNA 1700020N01 gene 767083 -3.41513823487 Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3 487872 -3.39467354943 924101 -3.38542408522 710293 -3.38122120735 804608 -3.3798980124 562485 -3.37711655469 638407 -3.36923374359 347777 -3.35964032237 614268 -3.35156453568 688046 -3.34821799444 564650 -3.34787973072 606388 -3.33971616739 632445 -3.33958560543 524988 -3.33953823901 606452 -3.3378655653 907925 -3.32582639558 923810 -3.32475404481 586618 -3.32088247139 885718 -3.30132133357 726778 -3.25911341715 383327 -3.22955433174 492467 -3.20607981452 926656 -3.20162472784 482989 -3.18987275155 509971 -3.17163390514 668093 -3.16621007831 872001 -3.16339737978 775847 -3.16203184984 828517 -3.16114790087 463565 -3.16040715934 892911 -3.15277054914 437939 -3.14504137571 768342 -3.14388471648 517684 -3.14222047406 904006 -3.13232841825 464739 -3.12875766783 905968 -3.12553859904 354854 -3.11705005344 613716 -3.11322453228 638934 -3.10421057824 642099 -3.09898510404 377059 -3.09542723867 759375 -3.09167742457 929878 -3.08096728243 921351 -3.08073284888 911557 -3.06837593117 877918 -3.06716291961 898210 -3.06682594632 485872 -3.06367738104 446793 -3.06346500541 833372 -3.05643136081 627526 -3.04613022727 595375 -3.03792363687 451538 -3.02713018764 929097 -3.01759986002 494196 -3.0090436527 530489 -3.00856369314 589735 -3.00664218484 816996 -2.9832158802 652637 -2.98037862707 311659 -2.96975031948 675426 -2.96739338134 819312 -2.95241922409 772079 -2.94616842248 719181 -2.93241881911 700456 -2.931166348 783681 -2.93069556524 560104 -2.91367715047 329613 -2.90720258908 721013 -2.9029010826 888478 -2.89298262884 484584 -2.89115546525 365817 -2.87112543049 773020 -2.86788576773 369967 -2.86148694091 371948 -2.85488275297 484195 -2.84635567229 732153 -2.84094882283 490710 -2.8379733612 606165 -2.83561561336 833940 -2.81670630237 916589 -2.81456704799 395888 -2.81198190936 874790 -2.80819328456 710959 -2.80723628437 926347 -2.79889206585 322325 -2.79723331858 413082 -2.79407756272 733421 -2.77632187974 456624 -2.77548756045 629278 -2.77448025137 541107 -2.77244535191 726622 -2.76714916319 764772 -2.76308592477 345631 -2.75774469882 351212 -2.7521606911 894559 -2.73300377795 924002 -2.73292547948 513774 -2.70815244024 484962 -2.70811652552 428209 -2.70694022403 907248 -2.698955356 313028 -2.69470408222 503137 -2.6925997561 669475 -2.69237784655 797198 -2.69065520132 633796 -2.68857045657 569169 -2.68851615463 587121 -2.68803735949 401554 -2.65672041071 596971 -2.64246653742 680655 -2.63851004116 522997 -2.63150284086 557094 -2.6310016726 483610 -2.62168170058 446055 -2.61740291167 924687 -2.61169203274 864480 -2.60603668849 452291 -2.60536153846 760166 -2.5981198866 797397 -2.59510014135 432495 -2.59115238676 629286 -2.58467578262 822257 -2.58088856792 862084 -2.57967909521 529462 -2.56981138908 418375 -2.5666107649 463074 -2.5662416545 648980 -2.56483671651 367299 -2.55985218312 303159 -2.55572186096 427293 -2.55557140285 925708 -2.53868442561 752340 -2.53348179875 634118 -2.52865123049 559153 -2.52797753428 925691 -2.527495428 395378 -2.52650971305 928610 -2.52520131744 750458 -2.524764031 825365 -2.52375345248 392437 -2.52015384698 558435 -2.51583779721 626106 -2.51311911745 440302 -2.51178250873 529160 -2.50627289895 474276 -2.50275315766 366625 -2.50160723607 751309 -2.49975580578 299322 -2.49900177282 559593 -2.49512404804 656780 -2.49054355388 772332 -2.47878693331 638437 -2.47833615223 456746 -2.47522436703 890083 -2.47475371905 760080 -2.47260024684 884319 -2.46801368362 525953 -2.46708543003 807657 -2.45959505926 377079 -2.45127477729 930152 -2.45067213328 557371 -2.44876526527 887721 -2.4475098904 912048 -2.44220356236 434637 -2.4388160619 543520 -2.43166757185 298631 -2.43001854912 701752 -2.42816776117 672476 -2.42573538022 757534 -2.41526088415 871400 -2.38888901823 622892 -2.387557421 924360 -2.38755297632 329691 -2.38694016424 766237 -2.38678016727 855776 -2.38012300071 682517 -2.37970644771 788783 -2.37737810713 746825 -2.37117779274 353425 -2.3665862068 789244 -2.35681943052 748793 -2.35317268827 335383 -2.35094092344 743607 -2.34843560027 876297 -2.34757680833 914040 -2.34066854299 477181 -2.3305252338 304430 -2.32633561809 888849 -2.32382910723 377697 -2.32362586776 781606 -2.32166698306 357179 -2.3102706 773714 -2.30793776788 412663 -2.30541008199 450069 -2.305302002 697471 -2.30503013505 336312 -2.30366033066 302886 -2.2977469511 782274 -2.2934197476 841863 -2.29280526199 841453 -2.29235314221 537278 -2.29226334785 419024 -2.29099003314 550403 -2.29087864613 910668 -2.28934903615 531985 -2.28868818502 794780 -2.28534732958 694090 -2.28334053764 332050 -2.28296678707 903861 -2.28025906539 546373 -2.27902362038 814680 -2.27741276769 657562 -2.27623456196 329038 -2.2724186745 349576 -2.27114634047 341473 -2.26843207343 461834 -2.26203921201 931538 -2.2617298047 543726 -2.25924073833 928328 -2.25768059303 410328 -2.25664320549 535794 -2.2545002135 554930 -2.247326457 850104 -2.23940681089 713976 -2.23663709482 698766 -2.2304006124 388365 -2.223079577 313693 -2.21856634219 651313 -2.214612626 339447 -2.21184133136 826056 -2.20298076812 832430 -2.19906119555 346587 -2.19810014368 908795 -2.19721639971 929172 -2.19687888571 907228 -2.19306142664 473893 -2.19180162246 905732 -2.18711534512 371943 -2.18678737895 562690 -2.18642336066 796639 -2.17869624669 713384 -2.17491980092 880720 -2.16547451976 561100 -2.1647572784 412304 -2.16393565477 529972 -2.16309050177 357302 -2.16145269157 513123 -2.15827248021 745918 -2.15762694879 931085 -2.15687810171 751890 -2.15497659969 542843 -2.15409901238 338874 -2.15366811233 714168 -2.15326300891 804184 -2.15163455922 766009 -2.14719761353 341276 -2.14310403515 915752 -2.13772649193 908080 -2.13684446269 573789 -2.13182025879 859193 -2.13039558243 853873 -2.12542713706 893169 -2.12016844746 905471 -2.11962772828 333496 -2.11761720883 776279 -2.11744612426 537031 -2.11463390768 700437 -2.11246530626 664813 -2.10679319941 605546 -2.10639092367 907012 -2.10586211811 930613 -2.10236818228 655464 -2.10109249646 341261 -2.10006062233 774411 -2.09820885282 493439 -2.09696648353 408563 -2.09126468792 451073 -2.09112599764 528813 -2.08894796567 382410 -2.08580058616 637227 -2.08139692823 548380 -2.07698659955 477088 -2.07524065512 830584 -2.07294422954 793415 -2.07215920748 585223 -2.07007753893 571384 -2.06723677282 668653 -2.06634703762 862650 -2.06620933675 615742 -2.06560620663 454846 -2.06349036983 738829 -2.0626579173 924589 -2.06211720739 891943 -2.06194677368 921243 -2.06081497189 511078 -2.05989791755 688150 -2.05962485709 742535 -2.04918906592 421679 -2.04785093594 300428 -2.04679528137 478326 -2.04555001623 824877 -2.0437260061 803312 -2.040413977 454362 -2.03948807761 776941 -2.03659486968 896596 -2.03122622662 576407 -2.03089149304 823389 -2.02848798753 774569 -2.02537870697 689484 -2.02413596281 388375 -2.02247295574 901296 -2.01989357512 686764 -2.01830514001 392440 -2.01784148773 784738 -2.01743292542 889651 -2.01697903459 741539 -2.01159157967 776773 -2.0113592496 930248 -2.00857434132 654917 -2.00630840998 360006 -2.0059559257 p value Gene_SymGene_Name 0.000122 Ccl5 chemokine (C-C motif) ligand 5 0.009991 Prrx1 paired related homeobox 1 3.38E-05 D12Ertd64 DNA segment, Chr 12, ERATO Doi 647, expressed 1.95E-05 Sdpr serum deprivation response 0.029493 Trim30 tripartite motif protein 30 0.000107 Clec2d C-type lectin domain family 2, member d 0.007834 0.009681 Mmp3 matrix metalloproteinase 3 0.000124 0.012907 Nnmt nicotinamide N-methyltransferase 0.002012 0.017301 0.003344 Mglap matrix gamma-carboxyglutamate (gla) protein 0.004242 Tnc tenascin C 0.016141 Col3a1 procollagen, type III, alpha 1 0.036179 0.029308 Cst6 cystatin E/M 1.68E-07 2.77E-05 0.007888 0.003495 Msln mesothelin 0.002334 Col1a2 procollagen, type I, alpha 2 0.007294 Loxl3 lysyl oxidase-like 3 0.039902 0.001249 0.001873 0.033513 Bnc1 basonuclin 1 0.007813 BC049816 cDNA sequence BC049816 0.009303 1810009M0RIKEN cDNA 1810009M01 gene 0.002256 Fgf7 fibroblast growth factor 7 2.19E-05 Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) 1.53E-05 Ogn osteoglycin 0.022431 Nr2f1 nuclear receptor subfamily 2, group F, member 1 8.69E-07 S100a4 S100 calcium binding protein A4 0.003472 Mmp1a matrix metalloproteinase 1a (interstitial collagenase) 0.002642 0.000824 Ifi202b interferon activated gene 202B 0.001371 Oasl2 2'-5' oligoadenylate synthetase-like 2 0.034432 Osr1 odd-skipped related 1 (Drosophila) 0.024424 Ddr2 discoidin domain receptor family, member 2 0.001639 Tgfb3 transforming growth factor, beta 3 0.014235 Rhoj ras homolog gene family, member J 0.006323 Scara3 scavenger receptor class A, member 3 0.007762 0.002556 Efemp1 epidermal growth factor-containing fibulin-like extracellular matrix protein 1 0.010691 Col5a2 procollagen, type V, alpha 2 5.08E-05 Dcn decorin 0.00612 Mx2 myxovirus (influenza virus) resistance 2 0.000481 Axl AXL receptor tyrosine kinase 0.000117 Fbln5 fibulin 5 0.001006 Serpinf1 serine (or cysteine) proteinase inhibitor, clade F, member 1 1.17E-06 0.020665 Gpr149 G protein-coupled receptor 149 0.043402 Rgs2 regulator of G-protein signaling 2 0.044079 Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.000246 Tm4sf1 transmembrane 4 superfamily member 1 0.020448 Casp11 caspase 11, apoptosis-related cysteine protease 0.005529 0.003783 0.049873 0.022417 Usp18 ubiquitin specific protease 18 0.01555 Cav2 caveolin 2 0.001914 0.00013 S100a6 S100 calcium binding protein A6 (calcyclin) 0.010877 Prkg2 protein kinase, cGMP-dependent, type II 0.005047 Ptx3 pentaxin related gene 0.026207 Irf5 interferon regulatory factor 5 0.016808 9130206I2 RIKEN cDNA 9130206I24 gene 0.008921 Ltbp2 latent transforming growth factor beta binding protein 2 0.027106 Abca8b ATP-binding cassette, sub-family A (ABC1), member 8b 0.010933 Csf1 colony stimulating factor 1 (macrophage) 0.013105 Prelp proline arginine-rich end leucine-rich repeat 0.007939 AI836003 expressed sequence AI836003 3.32E-08 Lox lysyl oxidase 0.004253 0.00579 0.000186 Dlk1 delta-like 1 homolog (Drosophila) 0.006578 Col1a1 procollagen, type I, alpha 1 0.00575 Cd34 CD34 antigen 0.000265 Lsp1 lymphocyte specific 1 0.002367 Anxa1 annexin A1 3.92E-07 Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.000518 Col6a3 procollagen, type VI, alpha 3 0.008738 Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 0.000848 Nfix nuclear factor I/X 0.007361 Klra20 killer cell lectin-like receptor subfamily A, member 20 0.006284 Prkcdbp protein kinase C, delta binding protein 0.006818 Aebp1 AE binding protein 1 0.031288 Sqrdl sulfide quinone reductase-like (yeast) 0.00058 Olfr787 olfactory receptor 787 0.005792 1.83E-06 Fbln2 fibulin 2 0.009677 Gypc glycophorin C 0.017604 0.001385 Irx1 Iroquois related homeobox 1 (Drosophila) 0.00054 Emp1 epithelial membrane protein 1 0.000129 Cpe carboxypeptidase E 0.048248 Pcdh7 protocadherin 7 0.020536 Fxyd4 FXYD domain-containing ion transport regulator 4 0.033741 Syt8 synaptotagmin 8 0.000822 Emp3 epithelial membrane protein 3 0.01547 Nupr1 nuclear protein 1 0.021819 0.034301 0.006893 7.94E-05 Ccl2 chemokine (C-C motif) ligand 2 2.16E-06 Gm1012 gene model 1012, (NCBI) 0.049347 Kcnk4 potassium channel, subfamily K, member 4 0.020356 Pgcp plasma glutamate carboxypeptidase 0.005333 Cpne2 copine II 0.00244 5730446D1RIKEN cDNA 5730446D14 gene 0.005742 Aqp1 aquaporin 1 0.000767 3.65E-08 Col16a1 procollagen, type XVI, alpha 1 0.001125 1.71E-05 0.022533 Vcam1 vascular cell adhesion molecule 1 8.80E-06 Arhgap24 Rho GTPase activating protein 24 0.021857 Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.000221 C1r complement component 1, r subcomponent 0.036759 Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.000226 Ccl9 chemokine (C-C motif) ligand 9 0.035572 0.001417 0.009738 0.000944 0.010232 Lbh limb-bud and heart 0.005831 0.001214 0.02332 Gpr85 G protein-coupled receptor 85 0.0191 0.000101 Ptrf polymerase I and transcript release factor 0.017424 Mmp10 matrix metalloproteinase 10 4.39E-07 Rbp1 retinol binding protein 1, cellular 0.002635 0.039738 3.85E-05 0.008269 8.04E-06 Nrp1 neuropilin 1 0.00012 Ccnd1 cyclin D1 0.008013 0.018427 Cyt1 cytokine like 1 0.025581 Sox9 SRY-box containing gene 9 2.17E-05 Lgals1 lectin, galactose binding, soluble 1 1.53E-06 4.12E-05 Edg3 endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 0.045125 0.025302 0.0002 Adamts5 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) 0.045267 Gdpd2 glycerophosphodiester phosphodiesterase domain containing 2 0.002699 Egr2 early growth response 2 0.002705 Itgbl1 integrin, beta-like 1 0.010442 0.001074 Grem1 gremlin 1 0.000522 Pdgfc platelet-derived growth factor, C polypeptide 0.018816 0.003576 Zfhx1b zinc finger homeobox 1b 0.001657 Plscr2 phospholipid scramblase 2 0.008223 Vim vimentin 0.029897 4930451E1RIKEN cDNA 4930451E10 gene 0.004328 Itga7 integrin alpha 7 0.000121 Igfbp7 insulin-like growth factor binding protein 7 0.007506 0.031948 Hoxb2 homeo box B2 3.92E-06 Fez1 fasciculation and elongation protein zeta 1 (zygin I) 0.010373 Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.044809 8.08E-05 0.003063 Hoxa2 homeo box A2 0.015756 Ptgs1 prostaglandin-endoperoxide synthase 1 0.000199 Mmp19 matrix metalloproteinase 19 0.003144 BC020188 cDNA sequence BC020188 0.001997 Pnma2 paraneoplastic antigen MA2 0.004438 0.002639 Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.048154 1.07E-07 Ecm1 extracellular matrix protein 1 0.014032 0.000261 Cxcl12 chemokine (C-X-C motif) ligand 12 0.000208 Sema7a sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A 0.009281 Slc4a4 solute carrier family 4 (anion exchanger), member 4 0.009196 Pip5k2b phosphatidylinositol-4-phosphate 5-kinase, type II, beta 0.000258 Parp3 poly (ADP-ribose) polymerase family, member 3 0.000399 Oas2 2'-5' oligoadenylate synthetase 2 0.022022 Aatf apoptosis antagonizing transcription factor 0.009534 Il1rl1 interleukin 1 receptor-like 1 0.037498 0.002097 2010004A0RIKEN cDNA 2010004A03 gene 0.044175 1700106J1RIKEN cDNA 1700106J16 gene 0.007164 Cdh13 cadherin 13 0.040404 0.009973 0.012811 0.006191 5.10E-05 H2-D1 histocompatibility 2, D region locus 1 0.016687 9.80E-05 0.012691 Klhl9 kelch-like 9 (Drosophila) 0.001909 Ltbp1 latent transforming growth factor beta binding protein 1 0.007997 Mtap6 microtubule-associated protein 6 4.56E-05 Crlf1 cytokine receptor-like factor 1 0.000492 Emilin2 elastin microfibril interfacer 2 6.11E-06 2310046G1RIKEN cDNA 2310046G15 gene 0.002028 Mmp9 matrix metalloproteinase 9 0.04824 Ifi1 interferon inducible protein 1 0.003047 Ccl7 chemokine (C-C motif) ligand 7 0.026499 0.010923 A530032D1RIKEN cDNA A530032D15Rik gene 0.002084 0.001892 0.003958 Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.049254 0.049461 0.00444 Egr1 early growth response 1 0.001183 AI467503 expressed sequence AI467503 0.007966 Iigp1 interferon inducible GTPase 1 0.047705 Col6a1 procollagen, type VI, alpha 1 0.001639 Igfbp6 insulin-like growth factor binding protein 6 0.046843 0.007556 Fosl1 fos-like antigen 1 0.004117 A630065K2RIKEN cDNA A630065K24 gene 3.29E-06 0.000221 Col4a5 procollagen, type IV, alpha 5 0.002093 Cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.03549 Bgn biglycan 0.009093 E030026I1 RIKEN cDNA E030026I10 gene 0.006637 0.029742 0.018119 V1rg3 vomeronasal 1 receptor, G3 0.002319 Fos FBJ osteosarcoma oncogene 0.00018 0.004951 0.045522 0.007479 1810057C1RIKEN cDNA 1810057C19 gene 0.007576 0.022229 2.75E-07 Loxl1 lysyl oxidase-like 1 0.001028 5.55E-06 0.028694 0.000361 0.048286 Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.000644 Cxcl1 chemokine (C-X-C motif) ligand 1 9.88E-05 Cyp2j6 cytochrome P450, family 2, subfamily j, polypeptide 6 0.002077 Slpi secretory leukocyte protease inhibitor 0.001523 Arhgdib Rho, GDP dissociation inhibitor (GDI) beta 0.004756 0.007977 G1p2 interferon, alpha-inducible protein 0.002274 0.026785 Ctso cathepsin O 0.008809 Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 0.036542 0.003031 0.047057 9030217H1RIKEN cDNA 9030217H17 gene 0.025861 Cyp2f2 cytochrome P450, family 2, subfamily f, polypeptide 2 0.027134 Dcamkl1 double cortin and calcium/calmodulin-dependent protein kinase-like 1 0.002099 0.041631 1700110N1RIKEN cDNA 1700110N18 gene 0.00859 0.002554 0.025766 0.035219 na similar to Ig heavy chain (myeloma M104E) - mouse (fragment) 0.01954 Myc myelocytomatosis oncogene 0.039726 Mbl2 mannose binding lectin (C) 0.00248 1110067I12RIKEN cDNA 1110067I12 gene 0.026327 Cspg4 chondroitin sulfate proteoglycan 4 0.012113 Dtx3l deltex 3-like (Drosophila) 2.22E-06 Tagln transgelin 0.007307 5430425J1RIKEN cDNA 5430425J12 gene 0.00079 0.015285 0.037958 0.022449 0.003042 Olfr197 olfactory receptor 197 0.043663 Tle2 transducin-like enhancer of split 2, homolog of Drosophila E(spl) 1.01E-05 6230427J0RIKEN cDNA 6230427J02 gene 0.010385 0.000677 Ptpre protein tyrosine phosphatase, receptor type, E 0.025644 Gstz1 glutathione transferase zeta 1 (maleylacetoacetate ) 0.023209 0.0233 Sp4 trans-acting transcription factor 4 0.007983 0.022188 2310002L0RIKEN cDNA 2310002L09 gene 0.026474 0.019167 0.000277 Timp1 tissue inhibitor of metalloproteinase 1 0.00011 Ltbp3 latent transforming growth factor beta binding protein 3 0.015352 0.014511 0.000998 Bdnf brain derived neurotrophic factor 0.029692 0.020125 3.05E-06 Capg capping protein (actin filament), gelsolin-like 0.042288 0.002741 na similar to carboxylesterase precursor 0.039845 Fzd2 frizzled homolog 2 (Drosophila) 0.002951 Olfr978 olfactory receptor 978 6.88E-05 0.021822 Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 0.023211 Mapk11 mitogen-activated protein kinase 11 0.009114 3.34E-05 0.027465 Hmga2 high mobility group AT-hook 2 0.049392 2610307O0RIKEN cDNA 2610307O08 gene 0.048419 0.014592 Gng8 guanine nucleotide binding protein (G protein), gamma 8 subunit 0.035098 0.002376 Csf1r colony stimulating factor 1 receptor 0.000436 Gas1 growth arrest specific 1 0.007255 0.01004 0.020861 0.005393 Plaur urokinase plasminogen activator receptor 3.06E-05 Sdc2 syndecan 2 0.001358 Stard13 serologically defined colon cancer antigen 13 0.011365 Gnao1 guanine nucleotide binding protein, alpha o 0.010238 Rgma RGM domain family, member A 6.14E-05 0.03277 Galntl2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2 0.004013 Trhr2 thyrotropin releasing hormone receptor 2 0.043129 5031439A0RIKEN cDNA 5031439A09 gene 0.003467 Slc39a9 solute carrier family 39 (zinc transporter), member 9 0.001762 Pcolce procollagen C-proteinase enhancer protein 0.011325 0.036438 BC021523 cDNA sequence BC021523 0.019189 5832418A0RIKEN cDNA 5832418A03 gene 0.031297 0.025563 Grik5 glutamate receptor, ionotropic, kainate 5 (gamma 2) 0.001998 0.011468 Olfr1502 olfactory receptor 1502 0.016876 P2ry14 purinergic receptor P2Y, G-protein coupled, 14 0.000653 Inhba inhibin beta-A 2.85E-05 Ifitm3 interferon induced transmembrane protein 3 0.001785 Pcdhb17 protocadherin beta 17 0.012048 Mef2c myocyte enhancer factor 2C 0.001733 Chst2 carbohydrate sulfotransferase 2 0.013722 Mscp mitochondrial solute carrier protein 0.005051 BC030396 cDNA sequence BC030396 0.004034 1.33E-05 7.91E-05 Mmd monocyte to macrophage differentiation-associated 0.000349 0.034734 0.011701 0.004251 0.017118 Freq frequenin homolog (Drosophila) 0.006205 1200013B0RIKEN cDNA 1200013B08 gene 0.020434 Olfr1303 olfactory receptor 1303 0.026323 Akr1c18 aldo-keto reductase family 1, member C18 0.014656 A930016D0RIKEN cDNA A930016D02 gene 0.003137 0.029817 Ebf1 early B-cell factor 1 0.041763 Negr1 neuronal growth regulator 1 0.036383 0.000692 na similar to hypothetical protein MGC35048 0.012567 0.002144 0.001783 0.019577 0.000588 Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.002793 0.001304 Cxcl10 chemokine (C-X-C motif) ligand 10 0.033045 0.000397 Rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 0.007463 2810441C0RIKEN cDNA 2810441C07 gene 0.001499 BC025600 cDNA sequence BC025600 0.038025 B830028P1RIKEN cDNA B830028P19 gene 7.39E-05 Gata2 GATA binding protein 2 0.041132 0.003246 Zfp521 zinc finger protein 521 0.035911 0.005672 Mmp2 matrix metalloproteinase 2 0.011226 Tmprss5 transmembrane protease, serine 5 (spinesin) 1.07E-06 Ngef neuronal guanine nucleotide exchange factor 0.026341 0.04303 4.45E-05 Prrx2 paired related homeobox 2 0.021316 0.017948 0.000696 Oas1h 2'-5' oligoadenylate synthetase 1H 0.004811 Inhbb inhibin beta-B 0.02857 Olfr1361 olfactory receptor 1361 0.016008 0.008871 0.00021 Socs3 suppressor of cytokine signaling 3 1.31E-05 D9Ucla1 DNA segment, Chr 9, University of California at Los Angeles 1 0.001228 Waspip Wiskott-Aldrich syndrome protein interacting protein 0.007713 Card4 caspase recruitment domain 4 0.031141 0.006382 Elf4 E74-like factor 4 (ets domain transcription factor) 0.004161 4930570C0RIKEN cDNA 4930570C03 gene 0.001855 E130112L2RIKEN cDNA E130112L23 gene 0.045868 Ggn gametogenetin 0.00759 0.034672 Sfxn3 sideroflexin 3 0.002559 Hic1 hypermethylated in cancer 1 0.029063 Opn1mw opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) 0.002425 0.00545 Colec12 collectin sub-family member 12 1.57E-06 1200013A0RIKEN cDNA 1200013A08 gene 0.003158 Ctxn cortexin 0.047903 0.046353 C130039O1RIKEN cDNA C130039O16 gene 0.000371 0.036888 Fxyd1 FXYD domain-containing ion transport regulator 1 0.000549 Ehd2 EH-domain containing 2 0.011985 0.039746 0.014991 Met met proto-oncogene 0.001866 Gstp2 glutathione S-transferase, pi 2 0.049908 Lgi1 leucine-rich repeat LGI family, member 1 0.000746 Ifi35 interferon-induced protein 35 0.044316 Fgfr1 fibroblast growth factor receptor 1 0.000113 Dok1 docking protein 1 0.001116 2610204M0RIKEN cDNA 2610204M08 gene 0.025913 Dnahc5 dynein, axonemal, heavy chain 5 0.002111 Bzrp benzodiazepine receptor, peripheral 0.001423 Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.000283 0.004821 1.49E-05 Grb10 growth factor receptor bound protein 10 0.021232 0.043326 0.016622 0.032022 na gene model 44, (NCBI) 0.00011 Gpr124 G protein-coupled receptor 124 0.015043 Hdgfrp3 hepatoma-derived growth factor, related protein 3 0.000147 Prkca protein kinase C, alpha 0.041002 0.034532 0.0029 2310047A0RIKEN cDNA 2310047A01 gene 0.030406 Cflar CASP8 and FADD-like apoptosis regulator 0.000546 0.012561 0.000422 Timp2 tissue inhibitor of metalloproteinase 2 0.02024 Sdccag33 serologically defined colon cancer antigen 33 3.35E-05 Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.00013 1810011O1RIKEN cDNA 1810011O10 gene 0.032162 Tcfap2a transcription factor AP-2, alpha 0.044158 0.000619 Gan giant axonal neuropathy 0.028736 0.000519 0.002581 0.047761 Cnot6l CCR4-NOT transcription complex, subunit 6-like 0.041615 0.029395 0.03419 Itga8 integrin alpha 8 0.021281 Ppnr per-pentamer repeat gene 0.0231 Rarres2 retinoic acid receptor responder (tazarotene induced) 2 0.000626 Arts1 type 1 tumor necrosis factor receptor shedding aminopeptidase regulator 0.01833 Sst somatostatin 0.03121 0.000179 Pdzrn3 PDZ domain containing RING finger 3 0.017735 Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 0.000325 Olfr39 olfactory receptor 39 0.000124 LOC10589 LY antigen-like 0.000371 Rab27a RAB27A, member RAS oncogene family 0.039153 Areg amphiregulin 7.15E-05 Lrp1 low density lipoprotein receptor-related protein 1 0.038756 9130218O1RIKEN cDNA 9130218O11 gene 0.008797 1110014J0 RIKEN cDNA 1110014J01 gene 0.004094 0.009428 0.000326 Ier3 immediate early response 3 0.004211 0.028396 4933424C1RIKEN cDNA 4933424C13 gene 0.023056 1110038B1RIKEN cDNA 1110038B12 gene 0.001051 0.047788 0.009439 Rem1 rad and gem related GTP binding protein 1 0.024109 Ephx1 epoxide 1, microsomal 6.29E-05 Pdlim2 PDZ and LIM domain 2 0.011995 0.031259 0.001451 Alox5ap arachidonate 5-lipoxygenase activating protein 0.000368 Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.012599 Ascl1 achaete-scute complex homolog-like 1 (Drosophila) 0.000694 Mmp14 matrix metalloproteinase 14 (membrane-inserted) 0.021262 0.00017 Rassf1 Ras association (RalGDS/AF-6) domain family 1 9.18E-05 Sox4 SRY-box containing gene 4 0.043741 0.011438 Bloc1s1 biogenesis of lysosome-related organelles complex-1, subunit 1 0.010105 0.046873 0.006512 Olfr971 olfactory receptor 971 0.000291 Gsdmdc1 gasdermin domain containing 1 0.027198 3300001H2RIKEN cDNA 3300001H21 gene 0.022838 0.031383 Olfr1350 olfactory receptor 1350 0.028581 0.000282 Th tyrosine hydroxylase 0.000769 Spp1 secreted phosphoprotein 1 0.001657 0.044675 Cxcl11 chemokine (C-X-C motif) ligand 11 0.020641 Rufy2 RUN and FYVE domain-containing 2 0.014294 0.029996 Ifi204 interferon activated gene 204 0.003966 0.04844 Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.006075 Rin1 Ras and Rab interactor 1 0.016897 Olfr624 olfactory receptor 624 0.048932 0.011232 0.004101 0.016335 Ndufs6 NADH dehydrogenase (ubiquinone) Fe-S protein 6 0.039214 0.037396 0.020385 0.001109 Nab2 Ngfi-A binding protein 2 3.18E-05 0.000142 0.046268 7.90E-05 Vgll4 vestigial like 4 (Drosophila) 0.001467 Thoc1 THO complex 1 0.007956 Tmem45a transmembrane protein 45a 0.014599 1700001P0RIKEN cDNA 1700001P01 gene 0.001937 Scgb1a1 secretoglobin, family 1A, member 1 (uteroglobin) 3.08E-05 Trim47 tripartite motif protein 47 0.023633 0.045749 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B Genes Upregulated during SCC-PSA1 Differentiation

Biological Process Count P-Value Benjamini Genitalia morphogenesis 2 3.70E-02 1.00E+00 Hormone metabolic process 3 6.50E-02 1.00E+00 Retina morphogenesis in camera-type eye 2 6.70E-02 1.00E+00 Vitamin transport 2 7.60E-02 1.00E+00 Carboxylic acid transport 3 7.70E-02 1.00E+00 Organic acid transport 3 7.90E-02 1.00E+00

Molecular Function Count P-Value Benjamini Vitamin binding 4 1.80E-02 9.90E-01 Peptidase activity, acting on L-amino acid peptides 8 1.90E-02 9.20E-01 Peptidase activity 8 2.40E-02 8.70E-01 Transmembrane transporter activity 9 3.20E-02 8.80E-01 Serine-type peptidase activity 4 7.20E-02 9.80E-01 Serine hydrolase activity 4 7.30E-02 9.60E-01 Ion transmembrane transporter activity 7 7.70E-02 9.50E-01 Vitamin transporter activity 2 7.90E-02 9.30E-01 Hydrolase activity, acting on glycosyl bonds 3 9.30E-02 9.40E-01

Kegg Pathway Count P-Value Benjamini Complement and coagulation cascades 3 4.20E-02 9.30E-01 Drug metabolism 3 4.20E-02 9.30E-01 Systemic lupus erythematosus 3 7.30E-02 9.10E-01 Genes Downregulated during SCC-PSA1 Differentiation

Biological Process Count P-Value Benjamini Regulation of cellular process 62 7.20E-05 7.30E-02 Positive regulation of transcription from RNA polymerase II promoter 11 1.50E-04 7.60E-02 Positive regulation of cellular process 22 1.60E-04 5.40E-02 Regulation of biological process 63 1.80E-04 4.70E-02 Rhombomere 3 development 3 2.70E-04 5.50E-02 Positive regulation of transcription 12 3.50E-04 6.00E-02 Positive regulation of gene expression 12 4.40E-04 6.40E-02 Positive regulation of transcription, DNA-dependent 11 4.90E-04 6.30E-02 Positive regulation of RNA metabolic process 11 5.20E-04 5.90E-02 Biological regulation 64 5.30E-04 5.40E-02

Molecular Function Count P-Value Benjamini Signal transducer activity 31 3.00E-03 5.00E-01 Molecular transducer activity 31 3.00E-03 5.00E-01 Transcription factor activity 13 4.00E-03 3.80E-01 Receptor activity 27 1.20E-02 6.20E-01 Transcription regulator activity 15 2.20E-02 7.20E-01 Sequence-specific DNA binding 9 2.70E-02 7.20E-01 Transmembrane receptor activity 21 3.10E-02 7.10E-01 Glycerophosphodiester phosphodiesterase activity 2 5.00E-02 8.20E-01 Transmembrane receptor protein tyrosine kinase activity 3 5.00E-02 7.80E-01 Protein binding 47 5.10E-02 7.50E-01 DNA binding 18 6.10E-02 7.70E-01 Growth factor activity 4 6.20E-02 7.40E-01 Protein dimerization activity 6 6.80E-02 7.50E-01

Biocarta Pathway Count P-Value Benjamini IL-2 Receptor Beta Chain in T cell Activation 4 1.60E-02 6.00E-01

Kegg Pathway Count P-Value Benjamini Pathways in cancer 9 6.20E-03 3.70E-01 Colorectal cancer 5 6.40E-03 2.10E-01 Cytokine-cytokine receptor interaction 7 1.80E-02 3.60E-01 Toll-like receptor signaling pathway 4 5.50E-02 6.40E-01