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Table S2.Up Or Down Regulated Genes in Tcof1 Knockdown Neuroblastoma N1E-115 Cells Involved in Differentbiological Process Anal

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Table S2.Up Or Down Regulated Genes in Tcof1 Knockdown Neuroblastoma N1E-115 Cells Involved in Differentbiological Process Anal Table S2.Up or down regulated genes in Tcof1 knockdown neuroblastoma N1E-115 cells involved in differentbiological process analysed by DAVID database Pop Pop Fold Term PValue Genes Bonferroni Benjamini FDR Hits Total Enrichment GO:0044257~cellular protein catabolic 2.77E-10 MKRN1, PPP2R5C, VPRBP, MYLIP, CDC16, ERLEC1, MKRN2, CUL3, 537 13588 1.944851 8.64E-07 8.64E-07 5.02E-07 process ISG15, ATG7, PSENEN, LOC100046898, CDCA3, ANAPC1, ANAPC2, ANAPC5, SOCS3, ENC1, SOCS4, ASB8, DCUN1D1, PSMA6, SIAH1A, TRIM32, RNF138, GM12396, RNF20, USP17L5, FBXO11, RAD23B, NEDD8, UBE2V2, RFFL, CDC GO:0051603~proteolysis involved in 4.52E-10 MKRN1, PPP2R5C, VPRBP, MYLIP, CDC16, ERLEC1, MKRN2, CUL3, 534 13588 1.93519 1.41E-06 7.04E-07 8.18E-07 cellular protein catabolic process ISG15, ATG7, PSENEN, LOC100046898, CDCA3, ANAPC1, ANAPC2, ANAPC5, SOCS3, ENC1, SOCS4, ASB8, DCUN1D1, PSMA6, SIAH1A, TRIM32, RNF138, GM12396, RNF20, USP17L5, FBXO11, RAD23B, NEDD8, UBE2V2, RFFL, CDC GO:0044265~cellular macromolecule 6.09E-10 MKRN1, PPP2R5C, VPRBP, MYLIP, CDC16, ERLEC1, MKRN2, CUL3, 609 13588 1.859332 1.90E-06 6.32E-07 1.10E-06 catabolic process ISG15, RBM8A, ATG7, LOC100046898, PSENEN, CDCA3, ANAPC1, ANAPC2, ANAPC5, SOCS3, ENC1, SOCS4, ASB8, DCUN1D1, PSMA6, SIAH1A, TRIM32, RNF138, GM12396, RNF20, XRN2, USP17L5, FBXO11, RAD23B, UBE2V2, NED GO:0030163~protein catabolic process 1.81E-09 MKRN1, PPP2R5C, VPRBP, MYLIP, CDC16, ERLEC1, MKRN2, CUL3, 556 13588 1.87839 5.64E-06 1.41E-06 3.27E-06 ISG15, ATG7, PSENEN, LOC100046898, CDCA3, ANAPC1, ANAPC2, ANAPC5, SOCS3, ENC1, SOCS4, ASB8, DCUN1D1, PSMA6, SIAH1A, TRIM32, RNF138, GM12396, RNF20, USP17L5, FBXO11, RAD23B, NEDD8, UBE2V2, RFFL, CDC GO:0009057~macromolecule catabolic process 3.79E-09 MKRN1, PPP2R5C, VPRBP, MYLIP, CDC16, ERLEC1, MKRN2, CUL3, 654 13588 1.781826 1.18E-05 2.36E-06 6.85E-06 ISG15, RBM8A, PGLYRP2, ATG7, LOC100046898, PSENEN, CDCA3, ANAPC1, ANAPC2, ANAPC5, SOCS3, ENC1, SOCS4, ASB8, DCUN1D1, CHID1, PSMA6, SIAH1A, TRIM32, RNF138, GM12396, RNF20, XRN2, USP17L5, FBXO11, RAD GO:0043632~modification-dependent 3.96E-09 MKRN1, PPP2R5C, MAN1B1, BAP1, VPRBP, CDC16, MYLIP, RNF181, 508 13588 1.904391 1.23E-05 2.06E-06 7.16E-06 macromolecule catabolic process ERLEC1, MKRN2, CUL3, FANCL, ISG15, ATG7, USP12, LOC100046898, DDA1, USP15, USP14, NFX1, USP13, CDCA3, DCAF15, ANAPC1, ANAPC2, ANAPC5, SOCS3, DDB1, ENC1, UBE2I, SOCS4, HERC1, UBE2C, ASB8, DCUN1D1, GO:0019941~modification-dependent protein 3.96E-09 MKRN1, PPP2R5C, MAN1B1, BAP1, VPRBP, CDC16, MYLIP, RNF181, 508 13588 1.904391 1.23E-05 2.06E-06 7.16E-06 catabolic process ERLEC1, MKRN2, CUL3, FANCL, ISG15, ATG7, USP12, LOC100046898, DDA1, USP15, USP14, NFX1, USP13, CDCA3, DCAF15, ANAPC1, ANAPC2, ANAPC5, SOCS3, DDB1, ENC1, UBE2I, SOCS4, HERC1, UBE2C, ASB8, DCUN1D1, GO:0033554~cellular response to stress 1.68E-08 MORF4L1, FGF14, ZMAT3, MLH1, INTS3, PRDX1, FANCL, NONO, 404 13588 1.986454 5.22E-05 7.45E-06 3.03E-05 ANKRD17, MYD88, 5730403B10RIK, SLK, FANCI, COL4A3BP, H2AFX, POLG2, CAT, CLN3, CDK1, PGAP2, DDB1, CCDC47, ZSWIM7, RAD51, EYA3, PYCR1, HIF1A, XPC, BAZ1B, RIF1, PSEN1, TIMELESS, MAPK9, NRK, RUVBL2, DMC1 GO:0046907~intracellular transport 2.47E-07 ENAH, CLTB, AP2S1, TRAPPC2L, BNIP3, CLTC, PEX7, CDC42, 431 13588 1.862013 7.69E-04 9.61E-05 4.46E-04 COPB2, HOOK2, AP2B1, AP1S1, DYNLL2, FXC1, VPS4B, RHOB, GLE1, TPR, GOLGA5, SEC24C, SEC24D, AGAP2, COX16, DYNC1I1, SEC23A, STX1A, ADAM10, KIF5B, RAN, GM9797, GM8894, ERGIC1, MFN2, KIF1B, AAAS, TIMM8A1, GO:0006259~DNA metabolic process 4.33E-07 MORF4L1, BNIP3, MLH1, INTS3, PRIM1, FANCL, NONO, ANKRD17, 421 13588 1.854015 0.001349 1.50E-04 7.84E-04 CDC45, SLK, FANCI, PRIM2, PSMC3IP, H2AFX, POLG2, DNAJC2, RBMS1, DDB1, MND1, ZSWIM7, MCM2, MCM3, RMI1, MCM5, RAD51, TNKS2, RFC5, EYA3, RFC3, RFC4, XPC, RFC2, RRM2, RRM1, ORC5L, RUVBL2, RUVBL1, DMC1, GO:0007049~cell cycle 7.33E-07 KIFC1, LOC100046080, PKMYT1, AURKA, AURKB, CDC16, CDKN2A, 611 13588 1.673319 0.002281 2.28E-04 0.001326 CASP8AP2, CDKN2C, VPS4B, H2AFX, DNAJC2, CDCA3, ANAPC1, ANAPC2, ANAPC5, RAN, MND1, TACC3, MAPK6, TIMELESS, SIAH1A, LOC100044746, MAPK7, PDCD6IP, ARL8B, STMN1, NUP43, BLCAP, EID1, NEK2, ANLN, CCNG1, GO:0006974~response to DNA damage stimulus 9.96E-07 MORF4L1, ZMAT3, MLH1, INTS3, NONO, FANCL, ANKRD17, 287 13588 2.030164 0.003097 2.82E-04 0.001801 5730403B10RIK, SLK, FANCI, H2AFX, POLG2, CDK1, PGAP2, DDB1, ZSWIM7, RAD51, EYA3, XPC, BAZ1B, RIF1, PSEN1, TIMELESS, RUVBL2, DMC1, NHEJ1, XRN2, REV3L, RAD23B, POLA1, HSPA1B, OBFC2A, XAB2, MIF, RBX1, PHLDA3 GO:0022402~cell cycle process 1.37E-06 KIFC1, LZTS2, SPIN1, LOC100046080, MLH1, CDC16, AURKB, MEN1, 393 13588 1.846241 0.004242 3.54E-04 0.002468 CGREF1, CDKN2A, PSMC3IP, H2AFX, DNAJC2, CDCA3, ANAPC1, CDK1, ANAPC2, ARHGEF2, ANAPC5, RAN, TPX2, MND1, UBE2I, TACC3, UBE2C, CDK2, RAD51, RBBP8, MFN2, TAF10, CHMP1A, TIMELESS, CCND2, SIAH1A, LOC1 GO:0022403~cell cycle phase 2.70E-06 KIFC1, LZTS2, SPIN1, LOC100046080, MLH1, CDC16, AURKB, 328 13588 1.910461 0.008366 6.46E-04 0.004878 PSMC3IP, H2AFX, DNAJC2, CDCA3, ANAPC1, CDK1, ANAPC2, ARHGEF2, ANAPC5, RAN, TPX2, MND1, UBE2I, UBE2C, TACC3, CDK2, RBBP8, RAD51, TAF10, CHMP1A, TIMELESS, CCND2, SIAH1A, LOC100044746, STMN1, RUVBL1, ARL GO:0000278~mitotic cell cycle 3.24E-06 KIFC1, LZTS2, AURKA, AURKB, CDC16, DNAJC2, CDCA3, ANAPC1, 244 13588 2.07255 0.010031 7.20E-04 0.005854 ANAPC2, CDK1, ARHGEF2, ANAPC5, RAN, UBE2I, UBE2C, CDK2, RBBP8, TAF10, CHMP1A, TIMELESS, CCND2, LOC100044746, RUVBL1, ARL8B, STMN1, NUP43, HAUS3, NEK2, POLA1, ANLN, CEP55, CCNG1, ITGB1, NCAPH, SAC3D GO:0000279~M phase 3.40E-06 KIFC1, LZTS2, SPIN1, LOC100046080, MLH1, CDC16, AURKB, 283 13588 1.981166 0.010532 7.06E-04 0.006147 PSMC3IP, H2AFX, CDCA3, ANAPC1, ANAPC2, CDK1, ARHGEF2, ANAPC5, RAN, TPX2, MND1, UBE2I, UBE2C, TACC3, CDK2, RAD51, CHMP1A, TIMELESS, SIAH1A, LOC100044746, RUVBL1, ARL8B, STMN1, DMC1, NUP43, HAUS3, NEK2, GO:0051301~cell division 1.36E-05 BMI1, KIFC1, LZTS2, AURKB, CDC16, TGFB2, CDC42, CDC45, 281 13588 1.917021 0.041343 0.002635 0.024513 CDKN2A, VPS4B, CDCA3, CDC7, ANAPC1, ANAPC2, CDK1, ARHGEF2, ANAPC5, RAN, UBE2I, UBE2C, CDK4, MCM5, CDK2, CHMP1A, TIMELESS, CCND2, LOC100044746, PDCD6IP, RUVBL1, ARL8B, NUP43, CKS1B, HAUS3, NEK2, ANLN, GO:0007067~mitosis 1.65E-05 KIFC1, HAUS3, LZTS2, NEK2, ANLN, CDC16, CEP55, AURKB, CCNG1, 190 13588 2.140845 0.050138 0.003021 0.029864 NCAPH, SAC3D1, PAFAH1B1, ZWILCH, CDCA3, ANAPC1, ANAPC2, CDK1, ARHGEF2, ANAPC5, RAN, CDC23, UBE2I, 9130404D08RIK, CDC25C, UBE2C, CDK2, SMC4, LOC100044900, LOC100045999, CHMP1A, CCNB2, TIMELESS, L GO:0000280~nuclear division 1.65E-05 KIFC1, HAUS3, LZTS2, NEK2, ANLN, CDC16, CEP55, AURKB, CCNG1, 190 13588 2.140845 0.050138 0.003021 0.029864 NCAPH, SAC3D1, PAFAH1B1, ZWILCH, CDCA3, ANAPC1, ANAPC2, CDK1, ARHGEF2, ANAPC5, RAN, CDC23, UBE2I, 9130404D08RIK, CDC25C, UBE2C, CDK2, SMC4, LOC100044900, LOC100045999, CHMP1A, CCNB2, TIMELESS, L GO:0000087~M phase of mitotic cell cycle 2.64E-05 KIFC1, HAUS3, LZTS2, NEK2, ANLN, CDC16, CEP55, AURKB, CCNG1, 194 13588 2.096704 0.079032 0.004563 0.047794 NCAPH, SAC3D1, PAFAH1B1, ZWILCH, CDCA3, ANAPC1, ANAPC2, CDK1, ARHGEF2, ANAPC5, RAN, CDC23, UBE2I, 9130404D08RIK, CDC25C, UBE2C, CDK2, SMC4, LOC100044900, LOC100045999, CHMP1A, CCNB2, TIMELESS, L GO:0048285~organelle fission 3.72E-05 KIFC1, HAUS3, LZTS2, NEK2, ANLN, CDC16, CEP55, AURKB, CCNG1, 197 13588 2.064774 0.109288 0.006073 0.067178 NCAPH, SAC3D1, PAFAH1B1, ZWILCH, CDCA3, ANAPC1, ANAPC2, CDK1, ARHGEF2, ANAPC5, RAN, CDC23, UBE2I, 9130404D08RIK, CDC25C, UBE2C, CDK2, SMC4, LOC100044900, LOC100045999, CHMP1A, CCNB2, TIMELESS, L GO:0006281~DNA repair 4.50E-05 MORF4L1, RAD23B, POLA1, MLH1, HSPA1B, INTS3, OBFC2A, XAB2, 222 13588 1.980816 0.130857 0.006988 0.081402 RBX1, NONO, FANCL, ANKRD17, SLK, FANCI, H2AFX, POLG2, FEN1, SSRP1, SHPRH, RAD51AP1, LOC100044333, MSH3, DDB1, EME1, MSH4, TREX1, ZSWIM7, ATR, RAD54L, RAD51, EYA3, XPC, CUL4A, PCNA, RUVBL2, DMC1, S GO:0006260~DNA replication 9.35E-05 POLA1, TK1, PRIM1, RPA2, CDC45, PRIM2, POLG2, DNAJC2, FEN1, 152 13588 2.169775 0.252587 0.013768 0.168907 RBMS1, GINS1, SSRP1, PHB, MCM2, MCM3, RMI1, MCM5, RAD51, RFC5, RFC3, RFC4, RFC2, HELB, RRM2, RRM1, PCNA, ORC5L, TNFAIP1, REV3L, REPIN1 GO:0006511~ubiquitin-dependent protein 1.51E-04 RAD23B, PPP2R5C, MAN1B1, BAP1, EDEM3, 2700078E11RIK, 141 13588 2.183112 0.374997 0.021137 0.272534 catabolic process LOC100045866, ERLEC1, RBX1, CUL3, UBE2D3, ARIH2, DUB2A, USP12, USP15, USP14, USP13, ANAPC2, NPLOC4, PCNP, ATE1, PSMA6, CUL4A, SIAH1A, USP48, TCEB1, CUL4B, TBL1X, USP17L5 GO:0010608~posttranscriptional regulation 3.44E-04 CALCR, CPEB2, IMPACT, MKNK2, MKNK1, IGF2BP3, MTIF2, LIN28A, 148 13588 2.079857 0.657057 0.045464 0.619483 of gene expression ZFP36L2, EIF4EBP1, TNRC6C, CDKN2A, DGCR8, RBM8A, SND1, PUM2, ZFP36, GTPBP4, NLRP5, STXBP1, CDK4, QK, TARBP2, SMO, APBB1, EIF4E2, SRP9, SERP1 GO:0006886~intracellular protein transport 6.11E-04 ARL6IP1, CLTB, NAPG, AP2S1, TIMM10, NFKBIA, RFFL, TIMM13, 276 13588 1.71276 0.85093 0.076243 1.099096 NAPB, CLTC, PEX7, RAB7, COPB2, AP2B1, AP1S1, FXC1, STX17, TAP2, PEX16, NUP54, SEC24C, TPR, SEC24D, COX16, SEC23A, ASPSCR1, STX1A, RAN, GM9797, YWHAE, MFN2, LOC100045999, YWHAG, TIMM8A1, ATG4D, GSK3 GO:0015031~protein transport 9.11E-04 MSR1, CLTB, ZMAT3, AP2S1, VPS53, VPS37C, TIMM50, SELENBP1, 651 13588 1.41852 0.941429 0.107297 1.634115 LOC100044204, CLTC, PEX7, HOOK2, COPB2, AP2B1, AP1S1, FXC1, ATG7, VPS4B, RHOB, GLE1, TPR, NUP35, SEC24C, SEC24D, KDELR1, COX16, SEC23A, SCAMP1, STX1A, SCAMP2, RAN, STXBP1, GM9797, NDUFA11, MFN2, C GO:0006310~DNA recombination 9.74E-04 RECQL4, RAD51AP1, MSH3, EME1, ZSWIM7, MLH1, MND1, OBFC2A, 75 13588
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