Table S2.Up or down regulated genes in Tcof1 knockdown neuroblastoma N1E-115 cells involved in differentbiological process analysed by DAVID database Pop Pop Fold Term PValue Genes Bonferroni Benjamini FDR Hits Total Enrichment GO:0044257~cellular protein catabolic 2.77E-10 MKRN1, PPP2R5C, VPRBP, MYLIP, CDC16, ERLEC1, MKRN2, CUL3, 537 13588 1.944851 8.64E-07 8.64E-07 5.02E-07 process ISG15, ATG7, PSENEN, LOC100046898, CDCA3, ANAPC1, ANAPC2,
ANAPC5, SOCS3, ENC1, SOCS4, ASB8, DCUN1D1, PSMA6, SIAH1A,
TRIM32, RNF138, GM12396, RNF20, USP17L5, FBXO11, RAD23B,
NEDD8, UBE2V2, RFFL, CDC
GO:0051603~proteolysis involved in 4.52E-10 MKRN1, PPP2R5C, VPRBP, MYLIP, CDC16, ERLEC1, MKRN2, CUL3, 534 13588 1.93519 1.41E-06 7.04E-07 8.18E-07 cellular protein catabolic process ISG15, ATG7, PSENEN, LOC100046898, CDCA3, ANAPC1, ANAPC2,
ANAPC5, SOCS3, ENC1, SOCS4, ASB8, DCUN1D1, PSMA6, SIAH1A,
TRIM32, RNF138, GM12396, RNF20, USP17L5, FBXO11, RAD23B,
NEDD8, UBE2V2, RFFL, CDC
GO:0044265~cellular macromolecule 6.09E-10 MKRN1, PPP2R5C, VPRBP, MYLIP, CDC16, ERLEC1, MKRN2, CUL3, 609 13588 1.859332 1.90E-06 6.32E-07 1.10E-06 catabolic process ISG15, RBM8A, ATG7, LOC100046898, PSENEN, CDCA3, ANAPC1,
ANAPC2, ANAPC5, SOCS3, ENC1, SOCS4, ASB8, DCUN1D1, PSMA6,
SIAH1A, TRIM32, RNF138, GM12396, RNF20, XRN2, USP17L5,
FBXO11, RAD23B, UBE2V2, NED
GO:0030163~protein catabolic process 1.81E-09 MKRN1, PPP2R5C, VPRBP, MYLIP, CDC16, ERLEC1, MKRN2, CUL3, 556 13588 1.87839 5.64E-06 1.41E-06 3.27E-06
ISG15, ATG7, PSENEN, LOC100046898, CDCA3, ANAPC1, ANAPC2,
ANAPC5, SOCS3, ENC1, SOCS4, ASB8, DCUN1D1, PSMA6, SIAH1A,
TRIM32, RNF138, GM12396, RNF20, USP17L5, FBXO11, RAD23B,
NEDD8, UBE2V2, RFFL, CDC
GO:0009057~macromolecule catabolic process 3.79E-09 MKRN1, PPP2R5C, VPRBP, MYLIP, CDC16, ERLEC1, MKRN2, CUL3, 654 13588 1.781826 1.18E-05 2.36E-06 6.85E-06
ISG15, RBM8A, PGLYRP2, ATG7, LOC100046898, PSENEN, CDCA3,
ANAPC1, ANAPC2, ANAPC5, SOCS3, ENC1, SOCS4, ASB8, DCUN1D1, CHID1, PSMA6, SIAH1A, TRIM32, RNF138, GM12396, RNF20, XRN2,
USP17L5, FBXO11, RAD
GO:0043632~modification-dependent 3.96E-09 MKRN1, PPP2R5C, MAN1B1, BAP1, VPRBP, CDC16, MYLIP, RNF181, 508 13588 1.904391 1.23E-05 2.06E-06 7.16E-06 macromolecule catabolic process ERLEC1, MKRN2, CUL3, FANCL, ISG15, ATG7, USP12,
LOC100046898, DDA1, USP15, USP14, NFX1, USP13, CDCA3,
DCAF15, ANAPC1, ANAPC2, ANAPC5, SOCS3, DDB1, ENC1, UBE2I,
SOCS4, HERC1, UBE2C, ASB8, DCUN1D1,
GO:0019941~modification-dependent protein 3.96E-09 MKRN1, PPP2R5C, MAN1B1, BAP1, VPRBP, CDC16, MYLIP, RNF181, 508 13588 1.904391 1.23E-05 2.06E-06 7.16E-06 catabolic process ERLEC1, MKRN2, CUL3, FANCL, ISG15, ATG7, USP12,
LOC100046898, DDA1, USP15, USP14, NFX1, USP13, CDCA3,
DCAF15, ANAPC1, ANAPC2, ANAPC5, SOCS3, DDB1, ENC1, UBE2I,
SOCS4, HERC1, UBE2C, ASB8, DCUN1D1,
GO:0033554~cellular response to stress 1.68E-08 MORF4L1, FGF14, ZMAT3, MLH1, INTS3, PRDX1, FANCL, NONO, 404 13588 1.986454 5.22E-05 7.45E-06 3.03E-05
ANKRD17, MYD88, 5730403B10RIK, SLK, FANCI, COL4A3BP, H2AFX,
POLG2, CAT, CLN3, CDK1, PGAP2, DDB1, CCDC47, ZSWIM7, RAD51,
EYA3, PYCR1, HIF1A, XPC, BAZ1B, RIF1, PSEN1, TIMELESS,
MAPK9, NRK, RUVBL2, DMC1
GO:0046907~intracellular transport 2.47E-07 ENAH, CLTB, AP2S1, TRAPPC2L, BNIP3, CLTC, PEX7, CDC42, 431 13588 1.862013 7.69E-04 9.61E-05 4.46E-04
COPB2, HOOK2, AP2B1, AP1S1, DYNLL2, FXC1, VPS4B, RHOB, GLE1,
TPR, GOLGA5, SEC24C, SEC24D, AGAP2, COX16, DYNC1I1, SEC23A,
STX1A, ADAM10, KIF5B, RAN, GM9797, GM8894, ERGIC1, MFN2,
KIF1B, AAAS, TIMM8A1,
GO:0006259~DNA metabolic process 4.33E-07 MORF4L1, BNIP3, MLH1, INTS3, PRIM1, FANCL, NONO, ANKRD17, 421 13588 1.854015 0.001349 1.50E-04 7.84E-04
CDC45, SLK, FANCI, PRIM2, PSMC3IP, H2AFX, POLG2, DNAJC2,
RBMS1, DDB1, MND1, ZSWIM7, MCM2, MCM3, RMI1, MCM5, RAD51,
TNKS2, RFC5, EYA3, RFC3, RFC4, XPC, RFC2, RRM2, RRM1, ORC5L, RUVBL2, RUVBL1, DMC1,
GO:0007049~cell cycle 7.33E-07 KIFC1, LOC100046080, PKMYT1, AURKA, AURKB, CDC16, CDKN2A, 611 13588 1.673319 0.002281 2.28E-04 0.001326
CASP8AP2, CDKN2C, VPS4B, H2AFX, DNAJC2, CDCA3, ANAPC1,
ANAPC2, ANAPC5, RAN, MND1, TACC3, MAPK6, TIMELESS, SIAH1A,
LOC100044746, MAPK7, PDCD6IP, ARL8B, STMN1, NUP43, BLCAP,
EID1, NEK2, ANLN, CCNG1,
GO:0006974~response to DNA damage stimulus 9.96E-07 MORF4L1, ZMAT3, MLH1, INTS3, NONO, FANCL, ANKRD17, 287 13588 2.030164 0.003097 2.82E-04 0.001801
5730403B10RIK, SLK, FANCI, H2AFX, POLG2, CDK1, PGAP2, DDB1,
ZSWIM7, RAD51, EYA3, XPC, BAZ1B, RIF1, PSEN1, TIMELESS,
RUVBL2, DMC1, NHEJ1, XRN2, REV3L, RAD23B, POLA1, HSPA1B,
OBFC2A, XAB2, MIF, RBX1, PHLDA3
GO:0022402~cell cycle process 1.37E-06 KIFC1, LZTS2, SPIN1, LOC100046080, MLH1, CDC16, AURKB, MEN1, 393 13588 1.846241 0.004242 3.54E-04 0.002468
CGREF1, CDKN2A, PSMC3IP, H2AFX, DNAJC2, CDCA3, ANAPC1, CDK1,
ANAPC2, ARHGEF2, ANAPC5, RAN, TPX2, MND1, UBE2I, TACC3,
UBE2C, CDK2, RAD51, RBBP8, MFN2, TAF10, CHMP1A, TIMELESS,
CCND2, SIAH1A, LOC1
GO:0022403~cell cycle phase 2.70E-06 KIFC1, LZTS2, SPIN1, LOC100046080, MLH1, CDC16, AURKB, 328 13588 1.910461 0.008366 6.46E-04 0.004878
PSMC3IP, H2AFX, DNAJC2, CDCA3, ANAPC1, CDK1, ANAPC2,
ARHGEF2, ANAPC5, RAN, TPX2, MND1, UBE2I, UBE2C, TACC3, CDK2,
RBBP8, RAD51, TAF10, CHMP1A, TIMELESS, CCND2, SIAH1A,
LOC100044746, STMN1, RUVBL1, ARL
GO:0000278~mitotic cell cycle 3.24E-06 KIFC1, LZTS2, AURKA, AURKB, CDC16, DNAJC2, CDCA3, ANAPC1, 244 13588 2.07255 0.010031 7.20E-04 0.005854
ANAPC2, CDK1, ARHGEF2, ANAPC5, RAN, UBE2I, UBE2C, CDK2,
RBBP8, TAF10, CHMP1A, TIMELESS, CCND2, LOC100044746,
RUVBL1, ARL8B, STMN1, NUP43, HAUS3, NEK2, POLA1, ANLN,
CEP55, CCNG1, ITGB1, NCAPH, SAC3D GO:0000279~M phase 3.40E-06 KIFC1, LZTS2, SPIN1, LOC100046080, MLH1, CDC16, AURKB, 283 13588 1.981166 0.010532 7.06E-04 0.006147
PSMC3IP, H2AFX, CDCA3, ANAPC1, ANAPC2, CDK1, ARHGEF2,
ANAPC5, RAN, TPX2, MND1, UBE2I, UBE2C, TACC3, CDK2, RAD51,
CHMP1A, TIMELESS, SIAH1A, LOC100044746, RUVBL1, ARL8B,
STMN1, DMC1, NUP43, HAUS3, NEK2,
GO:0051301~cell division 1.36E-05 BMI1, KIFC1, LZTS2, AURKB, CDC16, TGFB2, CDC42, CDC45, 281 13588 1.917021 0.041343 0.002635 0.024513
CDKN2A, VPS4B, CDCA3, CDC7, ANAPC1, ANAPC2, CDK1, ARHGEF2,
ANAPC5, RAN, UBE2I, UBE2C, CDK4, MCM5, CDK2, CHMP1A,
TIMELESS, CCND2, LOC100044746, PDCD6IP, RUVBL1, ARL8B,
NUP43, CKS1B, HAUS3, NEK2, ANLN,
GO:0007067~mitosis 1.65E-05 KIFC1, HAUS3, LZTS2, NEK2, ANLN, CDC16, CEP55, AURKB, CCNG1, 190 13588 2.140845 0.050138 0.003021 0.029864
NCAPH, SAC3D1, PAFAH1B1, ZWILCH, CDCA3, ANAPC1, ANAPC2,
CDK1, ARHGEF2, ANAPC5, RAN, CDC23, UBE2I, 9130404D08RIK,
CDC25C, UBE2C, CDK2, SMC4, LOC100044900, LOC100045999,
CHMP1A, CCNB2, TIMELESS, L
GO:0000280~nuclear division 1.65E-05 KIFC1, HAUS3, LZTS2, NEK2, ANLN, CDC16, CEP55, AURKB, CCNG1, 190 13588 2.140845 0.050138 0.003021 0.029864
NCAPH, SAC3D1, PAFAH1B1, ZWILCH, CDCA3, ANAPC1, ANAPC2,
CDK1, ARHGEF2, ANAPC5, RAN, CDC23, UBE2I, 9130404D08RIK,
CDC25C, UBE2C, CDK2, SMC4, LOC100044900, LOC100045999,
CHMP1A, CCNB2, TIMELESS, L
GO:0000087~M phase of mitotic cell cycle 2.64E-05 KIFC1, HAUS3, LZTS2, NEK2, ANLN, CDC16, CEP55, AURKB, CCNG1, 194 13588 2.096704 0.079032 0.004563 0.047794
NCAPH, SAC3D1, PAFAH1B1, ZWILCH, CDCA3, ANAPC1, ANAPC2,
CDK1, ARHGEF2, ANAPC5, RAN, CDC23, UBE2I, 9130404D08RIK,
CDC25C, UBE2C, CDK2, SMC4, LOC100044900, LOC100045999,
CHMP1A, CCNB2, TIMELESS, L
GO:0048285~organelle fission 3.72E-05 KIFC1, HAUS3, LZTS2, NEK2, ANLN, CDC16, CEP55, AURKB, CCNG1, 197 13588 2.064774 0.109288 0.006073 0.067178 NCAPH, SAC3D1, PAFAH1B1, ZWILCH, CDCA3, ANAPC1, ANAPC2,
CDK1, ARHGEF2, ANAPC5, RAN, CDC23, UBE2I, 9130404D08RIK,
CDC25C, UBE2C, CDK2, SMC4, LOC100044900, LOC100045999,
CHMP1A, CCNB2, TIMELESS, L
GO:0006281~DNA repair 4.50E-05 MORF4L1, RAD23B, POLA1, MLH1, HSPA1B, INTS3, OBFC2A, XAB2, 222 13588 1.980816 0.130857 0.006988 0.081402
RBX1, NONO, FANCL, ANKRD17, SLK, FANCI, H2AFX, POLG2, FEN1,
SSRP1, SHPRH, RAD51AP1, LOC100044333, MSH3, DDB1, EME1,
MSH4, TREX1, ZSWIM7, ATR, RAD54L, RAD51, EYA3, XPC, CUL4A,
PCNA, RUVBL2, DMC1, S
GO:0006260~DNA replication 9.35E-05 POLA1, TK1, PRIM1, RPA2, CDC45, PRIM2, POLG2, DNAJC2, FEN1, 152 13588 2.169775 0.252587 0.013768 0.168907
RBMS1, GINS1, SSRP1, PHB, MCM2, MCM3, RMI1, MCM5, RAD51,
RFC5, RFC3, RFC4, RFC2, HELB, RRM2, RRM1, PCNA, ORC5L,
TNFAIP1, REV3L, REPIN1
GO:0006511~ubiquitin-dependent protein 1.51E-04 RAD23B, PPP2R5C, MAN1B1, BAP1, EDEM3, 2700078E11RIK, 141 13588 2.183112 0.374997 0.021137 0.272534 catabolic process LOC100045866, ERLEC1, RBX1, CUL3, UBE2D3, ARIH2, DUB2A,
USP12, USP15, USP14, USP13, ANAPC2, NPLOC4, PCNP, ATE1,
PSMA6, CUL4A, SIAH1A, USP48, TCEB1, CUL4B, TBL1X, USP17L5
GO:0010608~posttranscriptional regulation 3.44E-04 CALCR, CPEB2, IMPACT, MKNK2, MKNK1, IGF2BP3, MTIF2, LIN28A, 148 13588 2.079857 0.657057 0.045464 0.619483 of gene expression ZFP36L2, EIF4EBP1, TNRC6C, CDKN2A, DGCR8, RBM8A, SND1, PUM2,
ZFP36, GTPBP4, NLRP5, STXBP1, CDK4, QK, TARBP2, SMO, APBB1,
EIF4E2, SRP9, SERP1
GO:0006886~intracellular protein transport 6.11E-04 ARL6IP1, CLTB, NAPG, AP2S1, TIMM10, NFKBIA, RFFL, TIMM13, 276 13588 1.71276 0.85093 0.076243 1.099096
NAPB, CLTC, PEX7, RAB7, COPB2, AP2B1, AP1S1, FXC1, STX17,
TAP2, PEX16, NUP54, SEC24C, TPR, SEC24D, COX16, SEC23A,
ASPSCR1, STX1A, RAN, GM9797, YWHAE, MFN2, LOC100045999,
YWHAG, TIMM8A1, ATG4D, GSK3 GO:0015031~protein transport 9.11E-04 MSR1, CLTB, ZMAT3, AP2S1, VPS53, VPS37C, TIMM50, SELENBP1, 651 13588 1.41852 0.941429 0.107297 1.634115
LOC100044204, CLTC, PEX7, HOOK2, COPB2, AP2B1, AP1S1, FXC1,
ATG7, VPS4B, RHOB, GLE1, TPR, NUP35, SEC24C, SEC24D, KDELR1,
COX16, SEC23A, SCAMP1, STX1A, SCAMP2, RAN, STXBP1, GM9797,
NDUFA11, MFN2, C
GO:0006310~DNA recombination 9.74E-04 RECQL4, RAD51AP1, MSH3, EME1, ZSWIM7, MLH1, MND1, OBFC2A, 75 13588 2.491866 0.951873 0.110138 1.746221
RAD54L, RAD51, NONO, PSMC3IP, H2AFX, RUVBL2, RUVBL1, DMC1,
XRN2
GO:0043161~proteasomal 0.001012 CUL3, RAD23B, UBE2D3, NPLOC4, PPP2R5C, MAN1B1, PCNP, EDEM3, 30 13588 3.664509 0.95722 0.110173 1.813385 ubiquitin-dependent protein catabolic TBL1X, ERLEC1 process
GO:0010498~proteasomal protein catabolic 0.001012 CUL3, RAD23B, UBE2D3, NPLOC4, PPP2R5C, MAN1B1, PCNP, EDEM3, 30 13588 3.664509 0.95722 0.110173 1.813385 process TBL1X, ERLEC1
GO:0045184~establishment of protein 0.001148 MSR1, CLTB, ZMAT3, AP2S1, VPS53, VPS37C, TIMM50, SELENBP1, 656 13588 1.407708 0.972055 0.119943 2.055877 localization LOC100044204, CLTC, PEX7, HOOK2, COPB2, AP2B1, AP1S1, FXC1,
ATG7, VPS4B, RHOB, GLE1, TPR, NUP35, SEC24C, SEC24D, KDELR1,
COX16, SEC23A, SCAMP1, STX1A, SCAMP2, RAN, STXBP1, GM9797,
NDUFA11, MFN2, C
GO:0045639~positive regulation of myeloid 0.001204 LIF, TESC, SMAP1, HIF1A, ID2, KLF10, STAT5A, MAPK14, 25 13588 3.95767 0.976544 0.121378 2.155404 cell differentiation LOC100047138, JAG1
GO:0007006~mitochondrial membrane 0.001603 MFN2, TIMM8A1, OPA1, FXC1, LOC100046998, TIMM10, BNIP3, 26 13588 3.805452 0.993226 0.153369 2.858529 organization GM9797, TIMM50, TIMM13, CLN8
GO:0034613~cellular protein localization 0.001683 ARL6IP1, CLTB, NAPG, AP2S1, TIMM10, NFKBIA, RFFL, TIMM13, 299 13588 1.617777 0.994727 0.155659 2.999707
NAPB, CLTC, PEX7, RAB7, COPB2, CDC42, AP2B1, AP1S1, FXC1,
STX17, TAP2, PEX16, NUP54, SEC24C, TPR, SEC24D, COX16,
SEC23A, ASPSCR1, STX1A, RAN, GM9797, YWHAE, MFN2, LOC100045999, YWHAG, TIMM8A1, ATG4
GO:0045637~regulation of myeloid cell 0.001688 ZFP36, TESC, STAT5A, LDB1, KLF10, NFKBIA, JAG1, LIF, HIF1A, 51 13588 2.802272 0.994817 0.151639 3.009393 differentiation SMAP1, ID2, MAPK14, LOC100047138, CLEC2D
GO:0070727~cellular macromolecule 0.001918 ARL6IP1, CLTB, NAPG, AP2S1, TIMM10, NFKBIA, RFFL, TIMM13, 301 13588 1.607027 0.997464 0.16567 3.411113 localization NAPB, CLTC, PEX7, RAB7, COPB2, CDC42, AP2B1, AP1S1, FXC1,
STX17, TAP2, PEX16, NUP54, SEC24C, TPR, SEC24D, COX16,
SEC23A, ASPSCR1, STX1A, RAN, GM9797, YWHAE, MFN2,
LOC100045999, YWHAG, TIMM8A1, ATG4
GO:0006457~protein folding 0.002329 FKBP6, FKBP4, VBP1, SEC63, PIN1, DNAJC17, LOC433064, SLMAP, 127 13588 1.990954 0.999297 0.192291 4.128369
TOR1A, PPIL4, PDRG1, ERO1L, TCP1, PPIF, CCT7, UXT, PPIH,
PPIG, PPIB, HSPA4L, GM7879, DNAJB1, AHSA1, FKBP2, DNAJB5
GO:0006091~generation of precursor 0.002441 NDUFB3, BC002163, LDHA, GNPDA1, CYC1, HK2, GM6293, UQCRQ, 261 13588 1.642711 0.999505 0.195442 4.323223 metabolites and energy LOC100044223, ATP5G3, NDUFB2, NDUFS7, NDUFS5, UQCR10, TPI1,
UQCR11, FXN, ATP5O, CAT, ERO1L, LOC100047429, GLRX, ENO1,
TXNL1, NDUFA5, NDUFA2, PFKL, SUCLG2, GM5506, SUCLG1, CS,
BPGM, NDUFA10, NDUFA1,
GO:0008104~protein localization 0.002771 VPS53, LOC100044204, SELENBP1, HOOK2, ATG7, VPS4B, GLE1, 753 13588 1.343167 0.999824 0.213422 4.894322
NUP35, SCAMP1, SCAMP2, RAN, TMSB10, TACC3, TIMM8A1, RAB12,
PDCD6IP, RAB10, NUP43, VPS26A, MYH7B, ARL6IP1, CAV3,
5430435G22RIK, NAPG, SNX5, NFKBIA, NEDD8, NAPB, RFFL, LMAN1,
RAB7, STX17, SNF8, NUP54,
GO:0018208~peptidyl-proline modification 0.002793 P4HB, P4HA2, FKBP6, P4HA1 4 13588 10.99353 0.999835 0.209728 4.931173
GO:0046365~monosaccharide catabolic 0.002831 LDHA, GNPDA1, PFKL, GM5506, HK2, BPGM, LOC100044223, HIBADH, 54 13588 2.64659 0.999853 0.207279 4.996175 process PGLS, TPI1, GM4735, RPIA, PGK1, MDH2, ENO1, MDH1
GO:0006915~apoptosis 0.003403 MEF2C, ITGB3BP, E2F1, FASTKD1, ZMAT3, BNIP3, TIMM50, TGFB2, 465 13588 1.442162 0.999975 0.238267 5.97708
CASP6, CDKN2A, 5730403B10RIK, SLK, CASP8AP2, SHARPIN, LOC100046998, BAG2, POU4F3, RHOB, FAM176A, OPA1, TBRG4,
BCL2L10, DDIT4, TAF10, TRIM35, PSEN1, BNIP1, SIAH1A, LCK,
GADD45G, PDCD6IP, MAPK7, EI
GO:0051726~regulation of cell cycle 0.003407 E2F1, STAT5A, BTC, INTS3, OBFC2A, ITGB1, TGFB2, LIF, CDC42, 214 13588 1.695264 0.999976 0.233292 5.983505
CDKN2A, RHOB, H2AFX, AATF, ZWILCH, RECQL4, CDK1, GTPBP4,
TBX3, CDC23, ATR, TACC3, CDK4, NFKBIL1, NRAS, CDKN1A,
CHMP1A, XPC, CCND2, MAPK14, GADD45G, SMC1A, GADD45B, APBB1
GO:0007007~inner mitochondrial membrane 0.003525 TIMM8A1, OPA1, FXC1, LOC100046998, TIMM10, GM9797, TIMM13 8 13588 6.870955 0.999983 0.235238 6.185202 organization
GO:0009263~deoxyribonucleotide 0.003525 TYMS, RRM2, ADK, DTYMK, RRM1 8 13588 6.870955 0.999983 0.235238 6.185202 biosynthetic process
GO:0010605~negative regulation of 0.004087 BMI1, COPS2, IMPACT, BNIP3, MLH1, CBX2, REST, CBX1, ZEB1, 506 13588 1.412212 0.999997 0.261891 7.137994 macromolecule metabolic process RBM9, MXI1, CBX5, FERD3L, MEN1, EIF4EBP1, CDKN2A, DGCR8,
SND1, NFX1, CLN3, GTPBP4, LEF1, MBD2, TRAT1, SUZ12, TARBP2,
CHMP1A, PSEN1, LOC100045300, TIMELESS, TGIF1, LRCH4, SRP9,
EID1, BCLAF1, MTDH, S
GO:0008219~cell death 0.00424 MEF2C, ITGB3BP, E2F1, FASTKD1, ZMAT3, BNIP3, TIMM50, TGFB2, 507 13588 1.409427 0.999998 0.264874 7.395291
CASP6, CDKN2A, 5730403B10RIK, CASP8AP2, SLK, SHARPIN,
LOC100046998, BAG2, POU4F3, RHOB, FAM176A, OPA1, TBRG4,
BCL2L10, DDIT4, C8A, TAF10, TRIM35, PSEN1, BNIP1, SIAH1A,
LCK, GADD45G, PDCD6IP, MAPK
GO:0012501~programmed cell death 0.004957 MEF2C, ITGB3BP, E2F1, FASTKD1, ZMAT3, BNIP3, TIMM50, TGFB2, 473 13588 1.41777 1 0.296489 8.592941
CASP6, CDKN2A, 5730403B10RIK, SLK, CASP8AP2, SHARPIN,
LOC100046998, BAG2, POU4F3, RHOB, FAM176A, OPA1, TBRG4,
BCL2L10, DDIT4, TAF10, TRIM35, PSEN1, BNIP1, SIAH1A, LCK,
GADD45G, PDCD6IP, MAPK7, EI GO:0046164~alcohol catabolic process 0.005081 LDHA, GNPDA1, PFKL, GM5506, HK2, BPGM, DBH, LOC100044223, 65 13588 2.367837 1 0.297079 8.799417
HIBADH, PGLS, TPI1, GM4735, RPIA, PGK1, MDH2, ENO1, MDH1
GO:0016192~vesicle-mediated transport 0.005533 CLTB, MSR1, GNPDA1, GLRA1, AP2S1, SYT8, TRAPPC2L, SYT6, 466 13588 1.415476 1 0.31314 9.546062
CLTC, CD209B, CDC42, COPB2, HOOK2, AP2B1, AP1S1, PACSIN1,
PACSIN2, VPS4B, RHOB, GOLGA5, SEC24C, SEC24D, KDELR1, AGAP2,
CLINT1, COX16, GHR, SCAMP1, SEC23A, CLN3, STX1A, STXBP1,
ERGIC1, BNIP1, PSEN1, S
GO:0006007~glucose catabolic process 0.006206 LDHA, PFKL, GM5506, HK2, BPGM, LOC100044223, HIBADH, PGLS, 52 13588 2.536968 1 0.337996 10.64648
TPI1, GM4735, RPIA, PGK1, MDH2, ENO1, MDH1
GO:0019320~hexose catabolic process 0.006206 LDHA, PFKL, GM5506, HK2, BPGM, LOC100044223, HIBADH, PGLS, 52 13588 2.536968 1 0.337996 10.64648
TPI1, GM4735, RPIA, PGK1, MDH2, ENO1, MDH1
GO:0001701~in utero embryonic development 0.006305 BMI1, 2610005L07RIK, COPS3, PITPNB, CDH1, EGLN1, KEAP1, 267 13588 1.564622 1 0.336559 10.80634
LOC100044223, ITGB1, XAB2, LIF, CUL3, ACVR1B, INPP5K,
SLC30A1, COL4A3BP, ENO1, GINS1, SOX10, NLRP5, ADAM10, TBX3,
SOCS3, GM5506, BIRC6, LEF1, SPINT1, MBNL1, RBBP8, ASCL2,
MFN2, HIF1A, CCNB2, GCM1, SA
GO:0007507~heart development 0.006376 MEF2C, ERBB3, ADRBK1, EGLN1, SOX9, ITGB1, TGFB2, FOXH1, 223 13588 1.626845 1 0.334039 10.92255
ATG7, COL4A3BP, NKX3-1, NKX2-5, MB, ALPK3, TBX3, TBX2, RXRA,
SMO, ACVR2B, SALL4, HIF1A, TSC1, ADM, PSEN1, ID2, GNAQ,
JMJD6, PKP2, PLN, MYH11, ID3, POFUT1, BMPR1A
GO:0006793~phosphorus metabolic process 0.006817 TBK1, STAT5A, STK35, PKMYT1, RPS6KB1, AURKA, AURKB, TGFB2, 866 13588 1.282155 1 0.346894 11.63406
MAP3K7, UQCR10, UQCR11, CSNK2A1, AAK1, TYRO3, STK24,
RPS6KC1, SCYL1, MAPK6, CAMK4, BAZ1B, MAPK9, MAPK7, EIF2AK2,
NEK7, MVD, ERBB3, NEK2, ASZ1, ADRBK1, DUSP11, ACP1, PXN, LIF,
DUSP19, SBK1, 2610018
GO:0006796~phosphate metabolic process 0.006817 TBK1, STAT5A, STK35, PKMYT1, RPS6KB1, AURKA, AURKB, TGFB2, 866 13588 1.282155 1 0.346894 11.63406 MAP3K7, UQCR10, UQCR11, CSNK2A1, AAK1, TYRO3, STK24,
RPS6KC1, SCYL1, MAPK6, CAMK4, BAZ1B, MAPK9, MAPK7, EIF2AK2,
NEK7, MVD, ERBB3, NEK2, ASZ1, ADRBK1, DUSP11, ACP1, PXN, LIF,
DUSP19, SBK1, 2610018
GO:0044275~cellular carbohydrate catabolic 0.006965 LDHA, GNPDA1, PFKL, GM5506, HK2, BPGM, LOC100044223, HIBADH, 60 13588 2.381931 1 0.347401 11.87267 process PGLS, TPI1, GM4735, RPIA, PGK1, MDH2, ENO1, MDH1
GO:0016265~death 0.007139 MEF2C, ITGB3BP, E2F1, FASTKD1, ZMAT3, BNIP3, TIMM50, TGFB2, 519 13588 1.376839 1 0.348885 12.15118
CASP6, CDKN2A, 5730403B10RIK, CASP8AP2, SLK, SHARPIN,
LOC100046998, BAG2, POU4F3, RHOB, FAM176A, OPA1, TBRG4,
BCL2L10, DDIT4, C8A, TAF10, TRIM35, PSEN1, BNIP1, SIAH1A,
LCK, GADD45G, PDCD6IP, MAPK
GO:0006396~RNA processing 0.008118 NAF1, GM5515, LOC636306, GM15596, TRMT2A, SNRPD2, MLH1, 437 13588 1.408782 1 0.380559 13.70434
INTS3, RBM9, PNN, NONO, CDKN2A, DGCR8, CTU1, RBM8A, INTS7,
LOC433064, GM6451, BAT1A, SRRM1, TGS1, ZFP36, PRPF31,
EXOSC7, EXOSC4, EXOSC2, PRPF39, MBNL1, RNMTL1, QK, TARBP2,
GM9722, SLU7, RBM39, GM7966
GO:0006270~DNA replication initiation 0.009118 CDC45, POLA1, MCM2, MCM3, MCM5 10 13588 5.496764 1 0.410345 15.26351
GO:0016310~phosphorylation 0.009173 BCKDK, TBK1, STAT5A, STK35, PKMYT1, RPS6KB1, AURKA, AURKB, 718 13588 1.301462 1 0.406517 15.34824
FES, GM6293, TGFB2, MAP3K7, ACVR1B, UQCR10, UQCR11, CSNK2A1,
SLK, FXN, AAK1, ATP5O, PAK1, LOC100047429, CDC7, TYRO3,
CDK1, ADAM10, MTAP2, STK24, RPS6KC1, PKDCC, PBK, CDK4,
ATP6V1D, CDK2, ATP6V1C1,
GO:0006261~DNA-dependent DNA replication 0.009706 PRIM1, CDC45, HELB, PRIM2, POLA1, MCM2, MCM3, MCM5, RAD51 34 13588 2.910051 1 0.418639 16.16877
GO:0044271~nitrogen compound biosynthetic 0.009871 KYNU, ATP1B3, DTYMK, PNP, TGFB2, CPOX, GUCY1A3, ATP5O, 302 13588 1.492499 1 0.418398 16.42087 process GM6742, IMPDH1, LOC100047429, IMPDH2, PCBD2, PCBD1, HMBS,
ATP6V1D, NME6, ATP6V1C1, RP2H, PYCR1, RRM2, ADK, RRM1, SMS, GM7669, DSCAML1, ASNS, AZIN1, ATP5G3, PPAT, TYMS, THTPA,
QTRTD1, GM7993, AANAT, GM
GO:0019953~sexual reproduction 0.010377 ACOX1, SPIN1, GNPDA1, GLRA1, LOC100046080, FST, TSNAX, SYT8, 386 13588 1.424032 1 0.428803 17.1885
MLH1, RPS6KB1, SYT6, TAF7L, FANCL, H2AFX, CREB3L4, NEURL1A,
SPIN4, NLRP5, QK, PROK2, ACVR2A, AAAS, SIAH1A, KLHL10, DMC1,
XRN2, GJA10, DHH, RAD23B, AGFG1, CREM, ADCYAP1R1, ASZ1,
HSPA1B, ITGB1, SP
GO:0009792~embryonic development ending in 0.010971 BMI1, ENAH, COPS3, PITPNB, ZEB1, MAP3K7, MEN1, CUL3, ACVR1B, 425 13588 1.396825 1 0.441367 18.08386 birth or egg hatching FXN, COL4A3BP, SOX10, NLRP5, ADAM10, SOCS3, GM5506, SPINT1,
LEF1, MBNL1, RBBP8, ASCL2, MFN2, ACVR2A, SMO, HIF1A, PSEN1,
ADM, GRN, TGIF1, GM7669, 2610005L07RIK, CDH1, KEAP1, EGLN1,
XAB2, ITGB1, L
GO:0034654~nucleobase, nucleoside, 0.011216 KYNU, ATP1B3, DTYMK, DSCAML1, PNP, ATP5G3, PPAT, TYMS, 179 13588 1.658242 1 0.443128 18.45014 nucleotide and nucleic acid biosynthetic THTPA, QTRTD1, GUCY1A3, ATP5O, IMPDH1, IMPDH2, process LOC100047429, ATP5J2, LOC100045567, AMPD2, ATP6V1D, AMPD3,
ATP13A2, NME6, ATP6V1C1, RP2H, ATP2A3, RRM2, ADK, RRM1,
ATP6V0A2
GO:0034404~nucleobase, nucleoside and 0.011216 KYNU, ATP1B3, DTYMK, DSCAML1, PNP, ATP5G3, PPAT, TYMS, 179 13588 1.658242 1 0.443128 18.45014 nucleotide biosynthetic process THTPA, QTRTD1, GUCY1A3, ATP5O, IMPDH1, IMPDH2,
LOC100047429, ATP5J2, LOC100045567, AMPD2, ATP6V1D, AMPD3,
ATP13A2, NME6, ATP6V1C1, RP2H, ATP2A3, RRM2, ADK, RRM1,
ATP6V0A2
GO:0006839~mitochondrial transport 0.011728 MFN2, TIMM8A1, PSEN1, KIF5B, UCP2, FXC1, TIMM10, SLC25A37, 42 13588 2.617507 1 0.452428 19.21022
BNIP3, GM9797, TIMM13
GO:0006508~proteolysis 0.011891 MKRN1, KLK1B8, CNDP2, PPP2R5C, VPRBP, MYLIP, CDC16, ERLEC1, 1034 13588 1.233316 1 0.451647 19.45094
MKRN2, CUL3, ISG15, ATG7, PSENEN, LOC100046898, CDCA3, ANAPC1, ANAPC2, F10, ANAPC5, SOCS3, ENC1, NRD1, SOCS4, ASB8,
DCUN1D1, C4BP, PSMA6, SIAH1A, TRIM32, BACE1, RNF138,
GM12396, RNF20, USP17L5, F
GO:0022613~ribonucleoprotein complex 0.011998 NAF1, GM5515, LOC636306, GM15596, DIMT1, MINA, EIF3A, WDR55, 137 13588 1.765384 1 0.449327 19.60739 biogenesis CDKN2A, BRIX1, GM6451, AATF, GEMIN8, NSA2, PRPF31, GTPBP4,
TSR2, EXOSC7, EXOSC4, EXOSC2, MBNL1, GM9634, NOP14, TARBP2,
GM9722, SLU7, GM7966, TFB1M, PES1
GO:0070647~protein modification by small 0.012287 BMI1, AURKAIP1, BAP1, BIRC6, NEDD8, PCNP, TRIM23, UBE2C, 104 13588 1.902726 1 0.45203 20.0318 protein conjugation or removal RBX1, SUZ12, NEDD4, SIAH1A, RNF2, ATG7, TRIM32, DUB2A,
USP12, USP17L5
GO:0042770~DNA damage response, signal 0.012498 CDK1, PGAP2, 5730403B10RIK, XPC, NUPR1, MAPK14, MLH1, H2AFX, 57 13588 2.314427 1 0.452575 20.34051 transduction ATR, SMC1A, PHLDA3, MIF
GO:0042981~regulation of apoptosis 0.01286 BMI1, SNCB, STAT5A, BTC, BNIP3, MLH1, PNP, PRDX1, TGFB2, 553 13588 1.331946 1 0.457027 20.86678
MAP3K7, MEN1, CASP6, CDKN2A, 5730403B10RIK, CASP8AP2, ATG7,
CLN3, PGAP2, ADNP, CTNNA1, BCL2L10, PROK2, SMO, TRIM35,
HIF1A, PSEN1, BNIP1, LCK, ADAM17, MAPK9, PRNP, CLN8, ALOX12,
THOC1, BCLAF1, CDK5R1
GO:0010629~negative regulation of gene 0.013021 BMI1, COPS2, BNIP3, CBX2, REST, CBX1, ZEB1, RBM9, MXI1, CBX5, 410 13588 1.394301 1 0.456183 21.09924 expression MEN1, FERD3L, DGCR8, SND1, NFX1, LEF1, MBD2, SUZ12, TARBP2,
CHMP1A, LOC100045300, TIMELESS, TGIF1, LRCH4, EID1, BCLAF1,
MTDH, STRAP, TH1L, LIN28A, SOX9, FOXH1, TCF21, TNRC6C,
DRAP1, NKX2-5, TCF
GO:0016052~carbohydrate catabolic process 0.013779 LDHA, GNPDA1, PFKL, GM5506, HK2, BPGM, LOC100044223, HIBADH, 81 13588 2.035838 1 0.47028 22.1889
PGLS, TPI1, CHID1, PGLYRP2, GM4735, RPIA, PGK1, MDH2, ENO1,
MDH1
GO:0043009~chordate embryonic development 0.013842 BMI1, ENAH, COPS3, PITPNB, ZEB1, MAP3K7, MEN1, CUL3, ACVR1B, 421 13588 1.383983 1 0.466914 22.27851 COL4A3BP, SOX10, NLRP5, ADAM10, SOCS3, GM5506, SPINT1, LEF1,
MBNL1, RBBP8, ASCL2, MFN2, ACVR2A, SMO, HIF1A, PSEN1, ADM,
GRN, TGIF1, GM7669, 2610005L07RIK, CDH1, KEAP1, EGLN1, XAB2,
ITGB1, LOC100
GO:0016044~membrane organization 0.013984 CAV3, PLDN, MSR1, TIMM10, BNIP3, TIMM50, TIMM13, CD209B, 272 13588 1.495443 1 0.465528 22.4801
PACSIN1, AP1S1, PACSIN2, FXC1, UPK1A, ATG7, LOC100046998,
PAFAH1B1, EHD1, CLINT1, COX16, GHR, CLN3, NPLOC4, OPA1,
STXBP1, LMNA, GM9797, ITGA3, MFN2, NRAS, MFN1, TIMM8A1,
RABEP1, BNIP1, JMJD6, ULK1,
GO:0060713~labyrinthine layer 0.015053 GCM1, ADM, SOCS3, LEF1, SPINT1, DNAJB6 17 13588 3.880069 1 0.485839 23.98542 morphogenesis
GO:0042127~regulation of cell 0.015089 BMI1, FOSL2, STAT5A, BTC, BAP1, ZEB1, PNP, TGFB2, H19, FNTB, 538 13588 1.328214 1 0.481885 24.0356 proliferation FANCL, MEN1, MYD88, CDKN2A, CDKN2C, HLX, LOC100047138,
GM6742, ASPH, GTPBP4, IL11RA1, CDK4, CTNNA1, MBD2, MFN2,
SUZ12, SMO, TRIM35, CD80, ADM, CCND2, GRN, TGIF1, ATPIF1,
CDCA7L, EIF2AK2, ALOX12,
GO:0043067~regulation of programmed cell 0.016618 BMI1, SNCB, STAT5A, BTC, BNIP3, MLH1, PNP, PRDX1, TGFB2, 560 13588 1.315297 1 0.510722 26.13988 death MAP3K7, MEN1, CASP6, CDKN2A, 5730403B10RIK, CASP8AP2, ATG7,
CLN3, PGAP2, ADNP, CTNNA1, BCL2L10, PROK2, SMO, TRIM35,
HIF1A, PSEN1, BNIP1, LCK, ADAM17, MAPK9, PRNP, CLN8, ALOX12,
THOC1, BCLAF1, CDK5R1
GO:0006417~regulation of translation 0.017981 CPEB2, IMPACT, MKNK2, MKNK1, IGF2BP3, MTIF2, CDK4, LIN28A, 100 13588 1.8689 1 0.533996 27.97013
QK, TARBP2, EIF4EBP1, TNRC6C, RBM8A, PUM2, SRP9, EIF4E2,
SERP1
GO:0032504~multicellular organism 0.018437 ACOX1, SPIN1, STAT5A, LOC100046080, FST, TSNAX, MLH1, 409 13588 1.370831 1 0.538204 28.57149 reproduction RPS6KB1, TAF7L, MEN1, FANCL, AGPAT6, CREB3L4, H2AFX, NEURL1A, SPIN4, IL11RA1, MBD2, QK, PROK2, ACVR2A, SIAH1A,
KLHL10, DMC1, XRN2, GJA10, DHH, RAD23B, AGFG1, ADCYAP1R1,
CREM, HK2, ASZ1, HSPA1B, ITGB1,
GO:0048609~reproductive process in a 0.018437 ACOX1, SPIN1, STAT5A, LOC100046080, FST, TSNAX, MLH1, 409 13588 1.370831 1 0.538204 28.57149 multicellular organism RPS6KB1, TAF7L, MEN1, FANCL, AGPAT6, CREB3L4, H2AFX,
NEURL1A, SPIN4, IL11RA1, MBD2, QK, PROK2, ACVR2A, SIAH1A,
KLHL10, DMC1, XRN2, GJA10, DHH, RAD23B, AGFG1, ADCYAP1R1,
CREM, HK2, ASZ1, HSPA1B, ITGB1,
GO:0045646~regulation of erythrocyte 0.018552 SMAP1, HIF1A, LDB1, STAT5A, MAPK14 12 13588 4.580636 1 0.535729 28.72331 differentiation
GO:0010941~regulation of cell death 0.01861 BMI1, SNCB, STAT5A, BTC, BNIP3, MLH1, PNP, PRDX1, TGFB2, 563 13588 1.308288 1 0.53219 28.79883
MAP3K7, MEN1, CASP6, CDKN2A, 5730403B10RIK, CASP8AP2, ATG7,
CLN3, PGAP2, ADNP, CTNNA1, BCL2L10, PROK2, SMO, TRIM35,
HIF1A, PSEN1, BNIP1, LCK, ADAM17, MAPK9, PRNP, CLN8, ALOX12,
THOC1, BCLAF1, CDK5R1
GO:0006733~oxidoreduction coenzyme 0.018931 PGLS, KYNU, TPI1, COQ9, RPIA, COQ7, HIBADH, COQ5, MDH1 38 13588 2.60373 1 0.533748 29.21922 metabolic process
GO:0055114~oxidation reduction 0.019332 ACOX1, CYP24A1, LDHA, CYC1, PRDX4, 4921521F21RIK, PRDX1, 672 13588 1.276034 1 0.536751 29.74066
GM6293, UQCRQ, HIBADH, SC4MOL, NDUFS7, FAR1, PECR, NDUFS5,
UQCR10, UQCR11, P4HA2, PLOD1, PLOD2, P4HA1, CPOX, ASPH, CAT,
AKR7A5, KDM5A, IMPDH1, IMPDH2, NQO2, TXNL1, SUOX, CBR3,
GRHPR, COQ7, NDUFA10,
GO:0045039~protein import into 0.019824 TIMM8A1, FXC1, TIMM10, GM9797, TIMM13 7 13588 6.282016 1 0.541326 30.37564 mitochondrial inner membrane
GO:0006944~membrane fusion 0.02187 MFN2, CLN3, MFN1, NPLOC4, PLDN, BNIP1, ITGA3 25 13588 3.078188 1 0.57264 32.95724
GO:0065003~macromolecular complex assembly 0.02294 GLRA1, TUBB2C, H2-D1, NAP1L1, MLH1, TAF7L, GTF2E2, H2AFV, 338 13588 1.398585 1 0.585764 34.27079 TUBB6, H2AFX, PAK1, DCTPP1, PRPF31, NLRP5, PCBD2, PCBD1,
MCM2, MBNL1, MBD2, TARBP2, TAF10, TAF12, SBF2, RRM2, RRM1,
SLU7, ATPIF1, WASL, PRNP, HIST1H2AB, HIST1H2AC, HIST1H2AG,
HIST1H2AD, FKBP4, HIST
GO:0000041~transition metal ion transport 0.022951 SLC39A14, LOC677143, FKBP4, SLC39A13, SFXN4, SFXN2, 70 13588 2.041655 1 0.581522 34.2844
1300017J02RIK, SLC30A1, SLC25A37, SLC39A6, CP, STEAP1,
SLC39A3, SLC31A1
GO:0019471~4-hydroxyproline metabolic 0.023266 P4HB, P4HA2, P4HA1 3 13588 10.99353 1 0.582174 34.66573 process
GO:0018401~peptidyl-proline hydroxylation 0.023266 P4HB, P4HA2, P4HA1 3 13588 10.99353 1 0.582174 34.66573 to 4-hydroxy-L-proline
GO:0043933~macromolecular complex subunit 0.023513 ENAH, GLRA1, TUBB2C, NAP1L1, H2-D1, MLH1, TAF7L, GTF2E2, 367 13588 1.377935 1 0.581751 34.96349 organization H2AFV, TUBB6, H2AFX, PAK1, DCTPP1, PRPF31, NLRP5, PCBD2,
PCBD1, MCM2, MBNL1, MBD2, TARBP2, TAF10, TAF12, SBF2, RRM2,
RRM1, SLU7, ATPIF1, WASL, STMN1, PRNP, XRN2, HIST1H2AB,
HIST1H2AC, HIST1H2AG, HIS
GO:0022900~electron transport chain 0.024287 TXNL1, NDUFB3, NDUFA5, BC002163, NDUFA2, CYC1, NDUFA10, 112 13588 1.766817 1 0.589459 35.89005
NDUFA1, UQCRQ, GM6293, NDUFA11, NDUFB2, NDUFV3, NDUFS7,
NDUFS5, UQCR10, UQCR11, ERO1L, STEAP1, GLRX
GO:0051289~protein homotetramerization 0.024907 PCBD2, PCBD1, H2-D1, ATPIF1, DCTPP1 13 13588 4.22828 1 0.594569 36.62289
GO:0032446~protein modification by small 0.025146 BMI1, AURKAIP1, BIRC6, PCNP, NEDD8, TRIM23, UBE2C, RBX1, 79 13588 1.94822 1 0.593917 36.90252 protein conjugation SUZ12, NEDD4, ATG7, RNF2, SIAH1A, TRIM32
GO:0040008~regulation of growth 0.025481 MORF4L1, ING2, IGFBPL1, IGFBP7, STAT5A, ZMAT3, HOXB13, 256 13588 1.460078 1 0.594695 37.29394
TGFB2, MEN1, WISP2, AGPAT6, CDKN2A, MYD88, FXN, SPNB4, HLX,
SEMA3A, DNAJC2, SERTAD1, GHR, SOCS3, LOC100044161, SOCS4,
TKT, GAS6, TNKS2, ATXN2, HIF1A, ULK1, SIAH1A, OGFR, RUVBL1, APBB1, SERP1, ALOX12
GO:0007276~gamete generation 0.025498 GJA10, RAD23B, DHH, ACOX1, SPIN1, AGFG1, LOC100046080, CREM, 331 13588 1.394949 1 0.590854 37.31369
ADCYAP1R1, FST, TSNAX, ASZ1, MLH1, RPS6KB1, HSPA1B, ITGB1,
TAF7L, FANCL, ZSCAN21, PVRL2, PAFAH1B3, PAFAH1B1, CREB3L4,
H2AFX, KDM3A, NEURL1A, PAFAH1B2, SPIN4, LOC100044333, MSH4,
LMNA, ZFP148, EH
GO:0009165~nucleotide biosynthetic process 0.025586 KYNU, ATP1B3, DTYMK, DSCAML1, PNP, ATP5G3, TYMS, THTPA, 174 13588 1.57953 1 0.588092 37.41605
GUCY1A3, ATP5O, IMPDH1, IMPDH2, LOC100047429, ATP5J2,
LOC100045567, AMPD2, ATP6V1D, AMPD3, ATP13A2, NME6,
ATP6V1C1, RP2H, ATP2A3, RRM2, ADK, RRM1, ATP6V0A2
GO:0034976~response to endoplasmic 0.026308 COL4A3BP, GSK3B, CCDC47, HSPA5, ERO1L, EIF2AK2, SERP1 26 13588 2.959796 1 0.594406 38.24924 reticulum stress
GO:0032989~cellular component 0.026694 CDK5R1, ENAH, AGFG1, CNP, SOX9, ITGB1, TGFB2, CUL3, OFD1, 351 13588 1.378106 1 0.595848 38.69002 morphogenesis CDC42, SPNB4, ANK3, COL4A3BP, LHX4, POU4F3, PAFAH1B1,
NEURL1A, SEMA3A, B3GNT2, DCX, FOXD1, DCLK1, COL18A1,
ARHGEF2, PTPRZ1, LOC100044161, NTNG1, STXBP1, LEF1, WWTR1,
CTNNA1, GAS7, DVL1, SLIT3, MFN2
GO:0007017~microtubule-based process 0.026852 HAUS3, KIFC1, PRKCZ, TUBB2C, ASZ1, MLH1, CNP, OFD1, KIF2C, 211 13588 1.510959 1 0.594121 38.86951
HOOK2, SAC3D1, DYNLL2, TUBB6, PAFAH1B1, NEURL1A, KIF2A,
DYNC1I1, KIF5B, MTAP2, TPX2, KTN1, TACC3, DCTN2, UXT, KIF1B,
LOC100044746, STMN1, XRN2, ACTR10, DYNLT1B
GO:0006916~anti-apoptosis 0.026957 PGAP2, TBX3, STAT5A, BIRC6, BNIP3, HSPA1B, TAX1BP1, BCL2L10, 88 13588 1.873897 1 0.5917 38.98895
PROK2, GSK3B, BNIP3L, LHX4, FAIM, PRNP, ALOX12
GO:0045597~positive regulation of cell 0.027194 LOC100048076, MSR1, STAT5A, JAG1, PNP, TGFB2, MEN1, LIF, 175 13588 1.570504 1 0.591116 39.25709 differentiation METRN, SMAP1, TIAM1, HLX, LOC100047138, NKX2-5, RUNX2, TESC,
SOCS3, LOC100045567, KLF10, SMAD4, SMO, HIF1A, ID2, MAPK14, LCK, NPTN, TGIF1, H2-AA
GO:0006098~pentose-phosphate shunt 0.029604 PGLS, TPI1, RPIA, HIBADH 8 13588 5.496764 1 0.618916 41.92124
GO:0060670~branching involved in embryonic 0.029604 GCM1, ADM, SOCS3, SPINT1 8 13588 5.496764 1 0.618916 41.92124 placenta morphogenesis
GO:0060712~spongiotrophoblast layer 0.029604 LIF, ADM, SOCS3, BIRC6 8 13588 5.496764 1 0.618916 41.92124 development
GO:0009060~aerobic respiration 0.031305 FXN, SUCLG2, SUCLG1, CS, CAT, MDH2, MDH1 27 13588 2.850174 1 0.636011 43.73456
GO:0006605~protein targeting 0.031805 ARL6IP1, RAN, TIMM10, NFKBIA, GM9797, TIMM13, YWHAE, PEX7, 133 13588 1.653162 1 0.6382 44.25735
MFN2, YWHAG, LOC100045999, ATG4D, TIMM8A1, FXC1, GSK3B,
PEX16, NUP54, TPR, XPO7, COX16, KPNA1, SRP9, LOC640204
GO:0009152~purine ribonucleotide 0.032002 ATP5J2, ATP1B3, LOC100045567, DSCAML1, AMPD2, ATP13A2, PNP, 107 13588 1.746635 1 0.636809 44.46183 biosynthetic process ATP5G3, ATP6V1D, AMPD3, NME6, RP2H, ATP6V1C1, ATP2A3, ATP5O,
IMPDH1, IMPDH2, ATP6V0A2, LOC100047429
GO:0048284~organelle fusion 0.03242 MFN2, CLN3, MFN1, PLDN, BNIP1 14 13588 3.92626 1 0.638006 44.89433
GO:0006468~protein amino acid 0.033239 BCKDK, TBK1, STAT5A, STK35, PKMYT1, RPS6KB1, AURKA, AURKB, 640 13588 1.253949 1 0.643709 45.73131 phosphorylation FES, TGFB2, MAP3K7, ACVR1B, CSNK2A1, SLK, AAK1, PAK1, CDC7,
TYRO3, CDK1, ADAM10, STK24, MTAP2, RPS6KC1, PKDCC, PBK,
CDK4, CDK2, ACVR2A, HUNK, PRKD2, ACVR2B, BAZ1B, CAMK4,
PSEN1, MAPK6, SCYL1, LCK,
GO:0030030~cell projection organization 0.034462 GM7669, CDK5R1, ENAH, LIMA1, ITGB4, CNP, CAPZB, PXN, TGFB2, 319 13588 1.378499 1 0.653632 46.95916
OFD1, CDC42, SPNB4, ANK3, ATG7, LHX4, POU4F3, NEURL1A,
SEMA3A, PAK1, B3GNT2, DCX, FOXD1, DCLK1, BAIAP2L1, MTAP2,
PTPRZ1, LOC100044161, NTNG1, STXBP1, WWTR1, GM7901, GAS7,
DVL1, SLIT3, SEMA6A, GM9
GO:0016567~protein ubiquitination 0.034574 BMI1, SUZ12, AURKAIP1, NEDD4, SIAH1A, RNF2, TRIM32, BIRC6, 66 13588 1.998823 1 0.651296 47.07025
PCNP, TRIM23, UBE2C, RBX1 GO:0060711~labyrinthine layer development 0.03542 GCM1, ADM, SOCS3, BIRC6, LEF1, SPINT1, EGLN1, DNAJB6 35 13588 2.512806 1 0.656819 47.90266
GO:0045934~negative regulation of 0.036044 BMI1, COPS2, MLH1, CBX2, ZEB1, CBX1, REST, RBM9, MXI1, CBX5, 397 13588 1.329192 1 0.659876 48.50952 nucleobase, nucleoside, nucleotide and MEN1, FERD3L, NFX1, GTPBP4, LEF1, MBD2, SUZ12, CHMP1A, nucleic acid metabolic process TIMELESS, LOC100045300, TGIF1, ATPIF1, LRCH4, EID1, BCLAF1,
MTDH, STRAP, TH1L, SOX9, FOXH1, TCF21, DRAP1, NKX2-5, TCF25,
ZBTB7A, TBX3, RFX5
GO:0006302~double-strand break repair 0.037612 EYA3, POLA1, MLH1, H2AFX, OBFC2A, RAD54L, NHEJ1, APBB1, 43 13588 2.300971 1 0.67232 50.00231
RAD51
GO:0010558~negative regulation of 0.038753 BMI1, COPS2, CBX2, REST, CBX1, ZEB1, RBM9, MXI1, CBX5, MEN1, 418 13588 1.315015 1 0.680056 51.06389 macromolecule biosynthetic process FERD3L, EIF4EBP1, NFX1, GTPBP4, LEF1, MBD2, SUZ12, CHMP1A,
LOC100045300, TIMELESS, TGIF1, LRCH4, SRP9, EID1, BCLAF1,
MTDH, STRAP, TH1L, SOX9, FOXH1, TCF21, DRAP1, AATF, NKX2-5,
TCF25, ZBTB7A, TB
GO:0045596~negative regulation of cell 0.040695 STAT5A, FST, NFKBIA, JAG1, ZEB1, REST, SOX9, ITGB1, TGFB2, 182 13588 1.5101 1 0.694845 52.82113 differentiation MEN1, LIF, IAPP, HLX, CLEC2D, SEMA3A, ZFP36, TBX3, LDB1,
LOC100044161, CTNNA1, WWTR1, PSEN1, RIF1, ULK1, CIT, BMPR1A
GO:0051129~negative regulation of cellular 0.040892 RECQL4, LIMA1, ARHGEF2, MTAP2, LOC100044161, RHOQ, TMSB10, 93 13588 1.77315 1 0.693322 52.99596 component organization CAPZB, PACSIN1, PSEN1, ULK1, PACSIN2, STMN1, SEMA3A, CIT,
GM9844, EPB4.9
GO:0006164~purine nucleotide biosynthetic 0.04138 ATP5J2, ATP1B3, LOC100045567, DSCAML1, AMPD2, ATP13A2, PNP, 137 13588 1.604895 1 0.694435 53.42674 process ATP5G3, ATP6V1D, AMPD3, NME6, RP2H, ATP6V1C1, THTPA, ATP2A3,
ADK, GUCY1A3, ATP5O, IMPDH1, IMPDH2, ATP6V0A2, LOC100047429
GO:0048675~axon extension 0.041461 ULK1, POU4F3, DCX, DCLK1 9 13588 4.886012 1 0.691901 53.49718
GO:0051172~negative regulation of nitrogen 0.041718 BMI1, COPS2, MLH1, CBX2, ZEB1, CBX1, REST, RBM9, MXI1, CBX5, 401 13588 1.315933 1 0.690967 53.72212 compound metabolic process MEN1, FERD3L, NFX1, GTPBP4, LEF1, MBD2, SUZ12, CHMP1A,
TIMELESS, LOC100045300, TGIF1, ATPIF1, LRCH4, EID1, BCLAF1, MTDH, STRAP, TH1L, SOX9, FOXH1, TCF21, DRAP1, NKX2-5, TCF25,
ZBTB7A, TBX3, RFX5
GO:0016481~negative regulation of 0.041945 BMI1, EID1, COPS2, BCLAF1, MTDH, STRAP, TH1L, CBX2, REST, 372 13588 1.329862 1 0.689783 53.92011 transcription ZEB1, CBX1, MXI1, SOX9, RBM9, CBX5, FERD3L, MEN1, FOXH1,
TCF21, DRAP1, TCF25, NKX2-5, NFX1, ZBTB7A, TBX3, TBX2, RFX5,
LEF1, WWTR1, MBD2, EHMT2, SUZ12, CHMP1A, NR1I2, SALL4,
LOC100045300, ID2, HDAC1
GO:0006096~glycolysis 0.04245 TPI1, LDHA, PFKL, GM5506, HK2, GM4735, BPGM, PGK1, 44 13588 2.248676 1 0.691053 54.35744
LOC100044223, MDH2, MDH1, ENO1
GO:0009260~ribonucleotide biosynthetic 0.042953 ATP5J2, ATP1B3, LOC100045567, DSCAML1, AMPD2, ATP13A2, PNP, 111 13588 1.683693 1 0.692277 54.78871 process ATP5G3, ATP6V1D, AMPD3, NME6, RP2H, ATP6V1C1, ATP2A3, ATP5O,
IMPDH1, IMPDH2, ATP6V0A2, LOC100047429
GO:0048193~Golgi vesicle transport 0.042988 SEC23A, SCYL1, TRAPPC2L, SEC22B, GOLGA5, SEC24C, LMAN1, 52 13588 2.11414 1 0.689462 54.81844
SEC24D, ERGIC1, COPE
GO:0006888~ER to Golgi vesicle-mediated 0.043055 SEC23A, TRAPPC2L, SEC22B, SEC24C, LMAN1, SEC24D, ERGIC1 29 13588 2.65361 1 0.68695 54.8758 transport
GO:0016197~endosome transport 0.043055 HOOK2, CDC42, VPS4B, RHOB, EHD1, VPS26A, AGAP2 29 13588 2.65361 1 0.68695 54.8758
GO:0043066~negative regulation of 0.043383 BMI1, SNCB, ERBB3, STAT5A, BTC, BNIP3, HSPA1B, PNP, MAP3K7, 239 13588 1.425939 1 0.686705 55.15488 apoptosis ATG7, LHX4, FAIM, NKX2-5, PGAP2, CLN3, TBX3, LOC100045567,
ADNP, BIRC6, CTNNA1, TAX1BP1, BCL2L10, PROK2, NRAS, SMO,
CDKN1A, GSK3B, BNIP3L, NEUROD1, PRNP, CLN8, ALOX12
GO:0060746~parental behavior 0.043739 NPAS3, DBH, MBD2 4 13588 8.245146 1 0.686701 55.4556
GO:0006269~DNA replication, synthesis of 0.043739 PRIM1, HELB, PRIM2 4 13588 8.245146 1 0.686701 55.4556
RNA primer
GO:0042711~maternal behavior 0.043739 NPAS3, DBH, MBD2 4 13588 8.245146 1 0.686701 55.4556
GO:0006612~protein targeting to membrane 0.043901 ARL6IP1, TIMM8A1, FXC1, TIMM10, GM9797, TIMM13, SRP9 22 13588 2.998235 1 0.685061 55.59226 GO:0032990~cell part morphogenesis 0.04573 CDK5R1, ENAH, CNP, TGFB2, OFD1, SPNB4, ANK3, COL4A3BP, 212 13588 1.451975 1 0.697229 57.10334
POU4F3, LHX4, B3GNT2, SEMA3A, DCX, FOXD1, DCLK1, PTPRZ1,
LOC100044161, NTNG1, STXBP1, WWTR1, GAS7, SLIT3, DVL1, MFN2,
SEMA6A, MFN1, ULK1, STMN1, APBB1
GO:0007010~cytoskeleton organization 0.04586 RHOJ, PRKCZ, HAUS3, ENAH, LIMA1, TLN1, AGFG1, S100A9, GYPA, 326 13588 1.348899 1 0.695321 57.20836
ASZ1, MLH1, RHOQ, CNP, CAPZB, ITGB1, PXN, OFD1, HOOK2,
SAC3D1, PAFAH1B1, CNN2, NEURL1A, AGAP2, RHOG, ARHGEF2,
MTAP2, TPX2, TMSB10, TACC3, GAS7, NRAS, UXT, CORO1A,
EPB4.1L1, LIMCH1, MYH11, STMN1,
GO:0016055~Wnt receptor signaling pathway 0.046814 LZTS2, WNT16, APC2, LDB1, LEF1, FRZB, PORCN, FZD6, DVL1, SMO, 130 13588 1.606746 1 0.700019 57.97553
DKK3, SDC1, CSNK2A1, NXN, CSNK1D, GM10031, GSK3B, RNF138,
FBXW2, WNT11
GO:0045892~negative regulation of 0.048047 BMI1, EID1, MTDH, STRAP, CBX2, REST, ZEB1, CBX1, MXI1, SOX9, 308 13588 1.356344 1 0.706729 58.94786 transcription, DNA-dependent CBX5, MEN1, FOXH1, TCF21, DRAP1, TCF25, NKX2-5, NFX1,
ZBTB7A, TBX3, TBX2, RFX5, LEF1, WWTR1, MBD2, EHMT2, SUZ12,
CHMP1A, SALL4, LOC100045300, TIMELESS, HDAC1, ID2, RNF2,
TGIF1, ID3, TBL1X, LOC10
GO:0051094~positive regulation of 0.050402 LOC100048076, MSR1, STAT5A, FST, JAG1, PNP, TGFB2, MEN1, 214 13588 1.438405 1 0.721441 60.74558 developmental process LIF, METRN, CDKN2A, SMAP1, TIAM1, HLX, LOC100047138, RHOB,
NKX2-5, RUNX2, TESC, SOCS3, LOC100045567, KLF10, SMAD4, SMO,
HIF1A, ID2, MAPK14, LCK, NPTN, TGIF1, H2-AA
GO:0050830~defense response to 0.05205 LYZ2, MYD88, LYZ1, TBK1, PGLYRP2, MYO1F 23 13588 2.867877 1 0.730357 61.95934
Gram-positive bacterium
GO:0009262~deoxyribonucleotide metabolic 0.05205 TYMS, LOC100045567, RRM2, ADK, DTYMK, RRM1, PNP 23 13588 2.867877 1 0.730357 61.95934 process
GO:0051262~protein tetramerization 0.05205 PCBD2, SBF2, PCBD1, H2-D1, ATPIF1, DCTPP1 23 13588 2.867877 1 0.730357 61.95934 GO:0051253~negative regulation of RNA 0.052118 BMI1, EID1, MTDH, STRAP, CBX2, REST, ZEB1, CBX1, MXI1, SOX9, 310 13588 1.347594 1 0.72806 62.00906 metabolic process CBX5, MEN1, FOXH1, TCF21, DRAP1, TCF25, NKX2-5, NFX1,
ZBTB7A, TBX3, TBX2, RFX5, LEF1, WWTR1, MBD2, EHMT2, SUZ12,
CHMP1A, SALL4, LOC100045300, TIMELESS, HDAC1, ID2, RNF2,
TGIF1, ID3, TBL1X, LOC10
GO:0043069~negative regulation of 0.054437 BMI1, SNCB, ERBB3, STAT5A, BTC, BNIP3, HSPA1B, PNP, MAP3K7, 244 13588 1.396719 1 0.741073 63.655 programmed cell death ATG7, LHX4, FAIM, NKX2-5, PGAP2, CLN3, TBX3, LOC100045567,
ADNP, BIRC6, CTNNA1, TAX1BP1, BCL2L10, PROK2, NRAS, SMO,
CDKN1A, GSK3B, BNIP3L, NEUROD1, PRNP, CLN8, ALOX12
GO:0045926~negative regulation of growth 0.054712 ZMAT3, LOC100044161, MEN1, ATXN2, HIF1A, MYD88, CDKN2A, FXN, 71 13588 1.858061 1 0.740186 63.84582
ULK1, SEMA3A, APBB1, DNAJC2, SERTAD1
GO:0060669~embryonic placenta 0.055322 GCM1, ADM, SOCS3, SPINT1 10 13588 4.397411 1 0.741493 64.26494 morphogenesis
GO:0034621~cellular macromolecular complex 0.056873 HIST1H2AB, HIST1H2AC, ENAH, HIST1H2AG, FKBP4, HIST1H2AD, 245 13588 1.391018 1 0.74876 65.31102 subunit organization TUBB2C, HIST1H2AE, NAP1L1, ASZ1, MLH1, GM11276, EIF3A,
H2AFV, TUBB6, H2AFX, GEMIN8, PAK1, H1FOO, PRPF31, NLRP5,
SHPRH, MBNL1, MCM2, MBD2, GAS7, DVL1, TAF10, TARBP2, CENPV,
HIST1H2AI, MYH11, SLU7, ST
GO:0060548~negative regulation of cell 0.056873 BMI1, SNCB, ERBB3, STAT5A, BTC, BNIP3, HSPA1B, PNP, MAP3K7, 245 13588 1.391018 1 0.74876 65.31102 death ATG7, LHX4, FAIM, NKX2-5, PGAP2, CLN3, TBX3, LOC100045567,
ADNP, BIRC6, CTNNA1, TAX1BP1, BCL2L10, PROK2, NRAS, SMO,
CDKN1A, GSK3B, BNIP3L, NEUROD1, PRNP, CLN8, ALOX12
GO:0007283~spermatogenesis 0.058009 DHH, ACOX1, RAD23B, AGFG1, CREM, ADCYAP1R1, TSNAX, MLH1, 255 13588 1.37958 1 0.753199 66.05869
HSPA1B, TAF7L, ZSCAN21, PVRL2, PAFAH1B3, PAFAH1B1, CREB3L4,
KDM3A, H2AFX, PAFAH1B2, NEURL1A, MSH4, LMNA, EHMT2, QK,
PROK2, ACVR2A, ZFP105, SIAH1A, BIK, KLHL10, DMC1, CIT, XRN2 GO:0048232~male gamete generation 0.058009 DHH, ACOX1, RAD23B, AGFG1, CREM, ADCYAP1R1, TSNAX, MLH1, 255 13588 1.37958 1 0.753199 66.05869
HSPA1B, TAF7L, ZSCAN21, PVRL2, PAFAH1B3, PAFAH1B1, CREB3L4,
KDM3A, H2AFX, PAFAH1B2, NEURL1A, MSH4, LMNA, EHMT2, QK,
PROK2, ACVR2A, ZFP105, SIAH1A, BIK, KLHL10, DMC1, CIT, XRN2
GO:0055085~transmembrane transport 0.058117 ZMAT3, SLC7A8, TIMM50, SLC7A4, KCNQ5, FXC1, SLC2A1, 460 13588 1.266646 1 0.751277 66.12946
SLC25A29, ATP5O, GLE1, KCNQ2, NUP35, LOC100047429, SLC22A1,
SLC12A6, SLC24A6, GM9797, SLC7A13, ATP6V1D, ATP6V1C1,
TIMM8A1, SLC25A37, TMCO3, NUP43, SERP1, MRPS17, SLC39A14,
LOC677143, SLC39A13, SLC37A3, T
GO:0016337~cell-cell adhesion 0.058168 PCDHA6, 2610005L07RIK, PCDHA7, PCDHA8, CDK5R1, PCDHA9, 236 13588 1.397482 1 0.74901 66.16224
PCDHA2, PCDHA3, LOC100046008, PCDHA4, PCDHA5, LMO7,
DSCAML1, CDH1, PCDHA1, PCDHB12, CDH2, CDH3, SOX9,
LOC100044363, PCDHAC2, PCDHAC1, PNN, CDH6, TGFB2, CDH22,
CDC42, PCP4, PVRL2, PCDHA10, PCDHA11, PCD
GO:0008284~positive regulation of cell 0.058526 BMI1, CNBP, FOSL2, STAT5A, BTC, ITGB1, PNP, TGFB2, FNTB, LIF, 284 13588 1.354836 1 0.748644 66.39402 proliferation MYD88, HLX, GM7993, GM6742, RUNX2, NKX2-5, COL18A1, RECQL4,
ODC1, GM9115, TBX3, LOC100045567, IL11RA1, BIRC6, SUZ12,
NRAS, SMO, CDKN1A, CORO1A, CD80, ADM, CCND2, GRN, TGIF1,
HBEGF, CDCA7L, MAB2
GO:0043603~cellular amide metabolic 0.05923 PGLS, KYNU, TPI1, STAT5A, RPIA, HIBADH, GHR, MDH1 39 13588 2.255083 1 0.750379 66.84566 process
GO:0006461~protein complex assembly 0.059467 GLRA1, FKBP4, TUBB2C, H2-D1, ASZ1, MLH1, CDH1, TAF7L, 227 13588 1.404459 1 0.749287 66.9965
GTF2E2, UPK1A, TUBB6, PAK1, DCTPP1, NLRP5, PCBD2, PCBD1,
MBD2, GAS7, DVL1, TAF10, TAF12, SBF2, RRM2, RRM1, MYH11,
ATPIF1, WASL, PRNP, XPO7
GO:0070271~protein complex biogenesis 0.059467 GLRA1, FKBP4, TUBB2C, H2-D1, ASZ1, MLH1, CDH1, TAF7L, 227 13588 1.404459 1 0.749287 66.9965 GTF2E2, UPK1A, TUBB6, PAK1, DCTPP1, NLRP5, PCBD2, PCBD1,
MBD2, GAS7, DVL1, TAF10, TAF12, SBF2, RRM2, RRM1, MYH11,
ATPIF1, WASL, PRNP, XPO7
GO:0051259~protein oligomerization 0.059517 GLRA1, PCBD2, SBF2, PCBD1, RRM2, UPK1A, RRM1, H2-D1, CDH1, 72 13588 1.832255 1 0.747079 67.02806
ATPIF1, PRNP, DCTPP1
GO:0031175~neuron projection development 0.060767 GM7669, CDK5R1, ENAH, CNP, TGFB2, SPNB4, ANK3, ATG7, LHX4, 218 13588 1.412013 1 0.752027 67.81137
POU4F3, PAK1, B3GNT2, SEMA3A, DCX, FOXD1, DCLK1, MTAP2,
PTPRZ1, LOC100044161, NTNG1, STXBP1, GM7901, GAS7, DVL1,
SLIT3, SEMA6A, GM9347, ULK1, PHGDH, STMN1, CIT, APBB1
GO:0046496~nicotinamide nucleotide 0.061019 PGLS, KYNU, TPI1, RPIA, HIBADH, MDH1 24 13588 2.748382 1 0.751044 67.96728 metabolic process
GO:0009820~alkaloid metabolic process 0.061019 PGLS, KYNU, TPI1, RPIA, HIBADH, MDH1 24 13588 2.748382 1 0.751044 67.96728
GO:0006769~nicotinamide metabolic process 0.061019 PGLS, KYNU, TPI1, RPIA, HIBADH, MDH1 24 13588 2.748382 1 0.751044 67.96728
GO:0008361~regulation of cell size 0.063947 ZMAT3, LOC100044161, CDK4, TGFB2, CDKN2A, TSC1, ULK1, 108 13588 1.628671 1 0.765238 69.72632
POU4F3, SEMA3A, DCX, CLN8, APBB1, DNAJC2, DCLK1, SERTAD1,
XRN2, ALOX12
GO:0009890~negative regulation of 0.065467 BMI1, COPS2, CBX2, REST, CBX1, ZEB1, RBM9, MXI1, CBX5, MEN1, 434 13588 1.266535 1 0.771092 70.60289 biosynthetic process FERD3L, EIF4EBP1, NFX1, GTPBP4, LEF1, MBD2, SUZ12, CHMP1A,
LOC100045300, TIMELESS, TGIF1, LRCH4, SRP9, EID1, BCLAF1,
MTDH, STRAP, TH1L, SOX9, FOXH1, TCF21, DRAP1, AATF, NKX2-5,
TCF25, ZBTB7A, TB
GO:0008380~RNA splicing 0.066382 STRAP, SNRPD2, TRPT1, RBM9, XAB2, SF3B4, PNN, SF4, NONO, 201 13588 1.422048 1 0.773581 71.11867
SF3B1, RBM8A, LOC433064, BAT1A, SRRM1, GEMIN8, RBM28,
SFRS12, PRPF31, PRPF39, MBNL1, QK, PPIH, JMJD6, SLU7,
GM7879, RBM39, SNRNP25, THOC1
GO:0048589~developmental growth 0.068015 GINS1, SOX10, GATM, SOX9, TIMP3, SMO, ADM, PSEN1, ULK1, MTPN, 100 13588 1.649029 1 0.779692 72.01882 POU4F3, HBEGF, DCX, DCLK1, BMPR1A
GO:0006600~creatine metabolic process 0.068559 GATM, STAT5A, GHR 5 13588 6.596117 1 0.78015 72.31241
GO:0009265~2'-deoxyribonucleotide 0.068559 TYMS, ADK, DTYMK 5 13588 6.596117 1 0.78015 72.31241 biosynthetic process
GO:0006364~rRNA processing 0.069938 NAF1, GM5515, LOC636306, GM15596, TSR2, EXOSC7, EXOSC4, 74 13588 1.782734 1 0.78474 73.04468
EXOSC2, GM9634, NOP14, DIMT1, CDKN2A, WDR55, GM9722, GM6451,
GM7966, TFB1M, PES1, NSA2
GO:0046661~male sex differentiation 0.070402 ACVR2A, DHH, TESC, TBX3, FKBP4, STAT5A, LOC100047138, BIK, 57 13588 1.928689 1 0.784763 73.28649
KLHL10, SOX9, BMPR1A
GO:0048738~cardiac muscle tissue 0.070402 TSC1, TBX2, RXRA, PLN, ATG7, MYH11, EGLN1, NKX2-5, ITGB1, 57 13588 1.928689 1 0.784763 73.28649 development TGFB2
GO:0031647~regulation of protein stability 0.070806 SMO, NLRP5, GTPBP4, CDKN2A, STXBP1, APBB1 25 13588 2.638447 1 0.784501 73.49581
GO:0006984~ER-nuclear signaling pathway 0.070806 GSK3B, CCDC47, HSPA5, ERO1L, EIF2AK2, SERP1 25 13588 2.638447 1 0.784501 73.49581
GO:0000122~negative regulation of 0.070818 BMI1, EID1, MTDH, STRAP, CBX2, ZEB1, MXI1, MEN1, FOXH1, 231 13588 1.38014 1 0.782341 73.50176 transcription from RNA polymerase II DRAP1, NKX2-5, TCF25, NFX1, ZBTB7A, TBX2, RFX5, LEF1, MBD2, promoter EHMT2, WWTR1, SUZ12, SALL4, LOC100045300, TIMELESS, HDAC1,
ID2, RNF2, TGIF1, ID3, DNAJB5
GO:0043393~regulation of protein binding 0.071076 GTPBP4, PSEN1, PCBD1, ATR 11 13588 3.997646 1 0.781391 73.63479
GO:0006183~GTP biosynthetic process 0.071076 RP2H, LOC100045567, DSCAML1, PNP, NME6 11 13588 3.997646 1 0.781391 73.63479
GO:0046039~GTP metabolic process 0.071076 RP2H, LOC100045567, DSCAML1, PNP, NME6 11 13588 3.997646 1 0.781391 73.63479
GO:0000904~cell morphogenesis involved in 0.071112 ENAH, CDK5R1, CNP, SOX9, TGFB2, CUL3, SPNB4, ANK3, POU4F3, 212 13588 1.400119 1 0.779369 73.6534 differentiation LHX4, B3GNT2, SEMA3A, DCX, FOXD1, DCLK1, COL18A1, PTPRZ1,
LOC100044161, NTNG1, STXBP1, LEF1, SLIT3, DVL1, SEMA6A,
HIF1A, ULK1, STMN1, APBB1
GO:0009150~purine ribonucleotide metabolic 0.072372 ATP5J2, ATP1B3, LOC100045567, DSCAML1, AMPD2, ATP13A2, PNP, 119 13588 1.570504 1 0.78325 74.29202 process ATP5G3, ATP6V1D, AMPD3, NME6, RP2H, ATP6V1C1, ATP2A3, ATP5O, IMPDH1, IMPDH2, ATP6V0A2, LOC100047429
GO:0000902~cell morphogenesis 0.072454 CDK5R1, ENAH, CNP, SOX9, TGFB2, OFD1, CUL3, CDC42, SPNB4, 309 13588 1.316377 1 0.781479 74.33319
ANK3, COL4A3BP, LHX4, POU4F3, SEMA3A, B3GNT2, DCX, FOXD1,
DCLK1, COL18A1, ARHGEF2, PTPRZ1, LOC100044161, NTNG1,
STXBP1, LEF1, WWTR1, CTNNA1, GAS7, DVL1, SLIT3, SEMA6A,
HIF1A, ULK1, MAPK14, EPB4.2,
GO:0051272~positive regulation of cell 0.074104 COL18A1, CORO1A, HIF1A, RRAS2, MYO1F, ADAM17, HBEGF, STMN1 41 13588 2.145079 1 0.787075 75.14599 motion
GO:0009100~glycoprotein metabolic process 0.074127 CLN3, ST6GAL1, IMPAD1, MAN1A2, EDEM3, GLCE, PORCN, ST3GAL1, 147 13588 1.495718 1 0.785059 75.15711
MGAT3, HIF1A, PSEN1, LARGE, ST3GAL5, BACE1, B3GNT2, OGT,
DOLPP1, POFUT1, DDOST, SERP1
GO:0000070~mitotic sister chromatid 0.074268 CHMP1A, NEK2, 9130404D08RIK, CIT, SMC4 18 13588 3.053758 1 0.783602 75.2258 segregation
GO:0016072~rRNA metabolic process 0.075561 NAF1, GM5515, LOC636306, GM15596, TSR2, EXOSC7, EXOSC4, 75 13588 1.758964 1 0.787431 75.84387
EXOSC2, GM9634, NOP14, DIMT1, CDKN2A, WDR55, GM9722, GM6451,
GM7966, TFB1M, PES1, NSA2
GO:0006397~mRNA processing 0.077122 FIP1L1, STRAP, MLH1, SNRPD2, RBM9, XAB2, SF3B4, SF3B2, PNN, 262 13588 1.342721 1 0.792339 76.57086
SF4, NONO, SF3B1, SFRS15, RBM8A, LOC433064, BAT1A, SRRM1,
GEMIN8, RBM28, SFRS12, ZFP36, PRPF31, CSTF3, PRPF39, MBNL1,
QK, PPIH, JMJD6, SLU7, GM7879, RBM39, SNRNP25, XRN2, THOC1
GO:0048812~neuron projection morphogenesis 0.077669 CDK5R1, ENAH, PTPRZ1, LOC100044161, NTNG1, STXBP1, CNP, 176 13588 1.436654 1 0.792695 76.82072
GAS7, DVL1, TGFB2, SLIT3, SEMA6A, SPNB4, ANK3, ULK1, POU4F3,
LHX4, B3GNT2, STMN1, SEMA3A, DCX, FOXD1, APBB1, DCLK1
GO:0030029~actin filament-based process 0.077669 RHOJ, MYL6, ENAH, LIMA1, TLN1, S100A9, RHOQ, CAPZB, ITGB1, 176 13588 1.436654 1 0.792695 76.82072
CNN2, PAFAH1B1, AGAP2, RHOG, ARHGEF2, TMSB10, GM8894, GAS7,
NRAS, CORO1A, EPB4.1L1, LIMCH1, MYH11, WASL, GM9844, APBB1 GO:0031327~negative regulation of cellular 0.078127 BMI1, COPS2, CBX2, REST, CBX1, ZEB1, RBM9, MXI1, CBX5, MEN1, 430 13588 1.252751 1 0.79266 77.02786 biosynthetic process FERD3L, EIF4EBP1, NFX1, GTPBP4, LEF1, MBD2, SUZ12, CHMP1A,
LOC100045300, TIMELESS, TGIF1, LRCH4, SRP9, EID1, BCLAF1,
MTDH, STRAP, TH1L, SOX9, FOXH1, TCF21, DRAP1, AATF, NKX2-5,
TCF25, ZBTB7A, TB
GO:0016071~mRNA metabolic process 0.080141 CALCR, FIP1L1, STRAP, MLH1, SNRPD2, RBM9, SF3B4, XAB2, 302 13588 1.310487 1 0.799256 77.91869
SF3B2, PNN, SF4, NONO, ZFP36L2, SF3B1, SFRS15, METTL3,
RBM8A, LOC433064, BAT1A, SRRM1, GEMIN8, RBM28, SFRS12,
ZFP36, PRPF31, CSTF3, PRPF39, MBNL1, QK, HNRPDL, PPIH,
JMJD6, SLU7, GM7879, RBM39, XRN2, S
GO:0007548~sex differentiation 0.080477 DHH, TESC, TBX3, STAT5A, FKBP4, MSH4, FST, SOX9, CDH6, AFP, 130 13588 1.522181 1 0.798678 78.06399
SRY, ACVR2A, TCF21, LOC100047138, NKX3-1, BIK, KLHL10, DMC1,
BMPR1A
GO:0048608~reproductive structure 0.080477 DHH, TESC, STAT5A, FKBP4, RXRA, MSH4, FST, HOXB13, SOX9, 130 13588 1.522181 1 0.798678 78.06399 development CDH6, AFP, TCF21, ACVR2A, CD44, LOC100047138, NKX3-1, BIK,
KLHL10, DMC1
GO:0034470~ncRNA processing 0.080823 GM5515, NAF1, LOC636306, GM15596, TRPT1, INTS3, LIN28A, 158 13588 1.461165 1 0.798148 78.21273
DIMT1, WDR55, CDKN2A, DGCR8, CTU1, INTS7, QTRTD1, GM6451,
NSA2, TSR2, EXOSC7, EXOSC4, EXOSC2, GM9634, NOP14, TARBP2,
GM9722, GM7966, TFB1M, PES1, RPP40
GO:0001702~gastrulation with mouth forming 0.081401 LOC100048076, ACVR2A, ACVR2B, LDB1, RNF2, SMAD4, CML2 26 13588 2.536968 1 0.798587 78.45912 second
GO:0042254~ribosome biogenesis 0.082151 NAF1, GM5515, GTPBP4, LOC636306, GM15596, TSR2, EXOSC7, 112 13588 1.570504 1 0.799727 78.77512
EXOSC4, EXOSC2, GM9634, MINA, NOP14, DIMT1, CDKN2A, WDR55,
GM9722, BRIX1, GM6451, AATF, GM7966, PES1, TFB1M, NSA2
GO:0032386~regulation of intracellular 0.082293 LOC100048076, SMO, CDKN2A, TNNC1, GSK3B, SMAD4, TNFSF14, 42 13588 2.094005 1 0.798371 78.8343 transport TACC3, PRDX1
GO:0009145~purine nucleoside triphosphate 0.082733 ATP5J2, ATP1B3, LOC100045567, DSCAML1, ATP13A2, PNP, 94 13588 1.637334 1 0.79824 79.01691 biosynthetic process ATP5G3, ATP6V1D, NME6, ATP6V1C1, RP2H, ATP2A3, ADK, ATP5O,
ATP6V0A2, LOC100047429
GO:0045333~cellular respiration 0.083847 NDUFA5, UQCR10, UQCR11, FXN, SUCLG2, SUCLG1, CS, CAT, 59 13588 1.86331 1 0.80083 79.47292
GM6293, MDH2, MDH1
GO:0051276~chromosome organization 0.086562 BMI1, MORF4L1, EZH1, ARID4B, NAP1L1, BNIP3, CBX2, CBX1, 404 13588 1.251738 1 0.809572 80.54573
CBX5, MEN1, H2AFV, H2AFX, KDM5A, MCM2, TNKS2, SUV420H2,
SUZ12, EYA3, CHMP1A, BAZ1B, RUVBL2, RUVBL1, SMARCA1, RNF20,
HIST1H2AB, HIST1H2AC, ING2, NEK2, HIST1H2AG, HIST1H2AD,
HIST1H2AE, HSPA1B, GM11276,
GO:0000819~sister chromatid segregation 0.087593 CHMP1A, NEK2, 9130404D08RIK, CIT, SMC4 19 13588 2.893034 1 0.811629 80.9388
GO:0034622~cellular macromolecular complex 0.088152 HIST1H2AB, HIST1H2AC, HIST1H2AG, FKBP4, HIST1H2AD, TUBB2C, 217 13588 1.367858 1 0.811892 81.14902 assembly HIST1H2AE, NAP1L1, ASZ1, MLH1, GM11276, EIF3A, H2AFV, TUBB6,
H2AFX, GEMIN8, PAK1, H1FOO, PRPF31, NLRP5, SHPRH, MBNL1,
MCM2, MBD2, GAS7, DVL1, TAF10, TARBP2, CENPV, HIST1H2AI,
MYH11, SLU7, XPO7, HI
GO:0006575~cellular amino acid derivative 0.088249 GM7669, KYNU, SNCAIP, SNCB, STAT5A, AZIN1, TGFB2, P4HA2, 141 13588 1.481397 1 0.81043 81.18528 metabolic process P4HA1, MTPN, GM7993, AANAT, GM6742, GM14680, GHR, P4HB,
ODC1, GM9115, GATM, DBH, GM7901, TPMT, GM9347, PHGDH, SMS,
MYH7B
GO:0009142~nucleoside triphosphate 0.088289 ATP5J2, ATP1B3, LOC100045567, DSCAML1, ATP13A2, PNP, 95 13588 1.620099 1 0.808757 81.19985 biosynthetic process ATP5G3, ATP6V1D, NME6, ATP6V1C1, RP2H, ATP2A3, ADK, ATP5O,
ATP6V0A2, LOC100047429
GO:0048588~developmental cell growth 0.088584 ULK1, POU4F3, DCX, DCLK1 12 13588 3.664509 1 0.808052 81.30982
GO:0007340~acrosome reaction 0.088584 GNPDA1, GLRA1, SYT8, SYT6 12 13588 3.664509 1 0.808052 81.30982 GO:0006298~mismatch repair 0.088584 ANKRD17, MSH3, MSH4, MLH1 12 13588 3.664509 1 0.808052 81.30982
GO:0044092~negative regulation of 0.089773 CAV3, CLN3, GTPBP4, GABBR1, TRIB3, NFKBIA, HSPA1B, SMO, 132 13588 1.499117 1 0.810664 81.74556 molecular function DUSP19, SSTR2, CDKN1A, CDKN2A, PSEN1, GADD45G, ATPIF1, CAT,
GADD45B, CLN8
GO:0007242~intracellular signaling cascade 0.092823 RHOJ, GNA15, FGF14, STAT5A, RHOQ, RRAD, TNFSF14, MLH1, 915 13588 1.153419 1 0.819836 82.82053
RPS6KB1, RBM9, IQGAP1, MAP3K7, CDC42, ARL5A, MYD88, PLCB4,
5730403B10RIK, TIAM2, CLCF1, TIAM1, RHOB, B230208H17RIK,
GUCY1A3, H2AFX, PLCB1, AGAP2, RHOG, COX16, ZFP36, PGAP2,
CDK1, ARHGEF2, SOCS3, RXRA,
GO:0060021~palate development 0.093068 LOC100048076, MEN1, ACVR2B, SMAD4, LEF1, ASPH, BMPR1A, 35 13588 2.198706 1 0.81895 82.90423
PLEKHA1
GO:0046822~regulation of nucleocytoplasmic 0.093068 LOC100048076, SMO, CDKN2A, GSK3B, SMAD4, TNFSF14, TACC3, 35 13588 2.198706 1 0.81895 82.90423 transport PRDX1
GO:0032535~regulation of cellular 0.093601 LIMA1, ZMAT3, LOC100044161, TMSB10, CDK4, CAPZB, TGFB2, 161 13588 1.433938 1 0.819075 83.0852 component size CORO1A, CDKN2A, TSC1, ULK1, POU4F3, SEMA3A, DCX, DNAJC2,
CLN8, APBB1, GM9844, EPB4.9, DCLK1, SERTAD1, XRN2, ALOX12
GO:0006979~response to oxidative stress 0.094355 GATM, PRDX1, PARK7, PYCR1, HIF1A, MTF1, PSEN1, UCP2, TOR1A, 87 13588 1.642711 1 0.81996 83.33785
LIAS, CAT, PRNP, CLN8
GO:0000075~cell cycle checkpoint 0.095836 CDK1, XPC, MAPK14, H2AFX, INTS3, ATR, ZWILCH, OBFC2A, SMC1A 52 13588 1.902726 1 0.823292 83.82363
GO:0006573~valine metabolic process 0.096767 STAT5A, HIBADH, GHR 6 13588 5.496764 1 0.824717 84.12207
GO:0019530~taurine metabolic process 0.096767 GM7669, GM9347, STAT5A, PHGDH, GM7901, GHR 6 13588 5.496764 1 0.824717 84.12207
GO:0000239~pachytene 0.096767 MLH1, DMC1, EHMT2 6 13588 5.496764 1 0.824717 84.12207
GO:0006732~coenzyme metabolic process 0.09774 KYNU, OXCT2A, SUCLG2, SUCLG1, CS, COQ9, ACOT6, ACSS2, COQ7, 143 13588 1.460678 1 0.826257 84.42854
HIBADH, COQ5, PGLS, TPI1, LIAS, RPIA, SCP2, MYH7B, MDH2, MDH1
GO:0001892~embryonic placenta development 0.098727 LIF, HIF1A, GCM1, ADM, SOCS3, BIRC6, LEF1, SPINT1, EGLN1, 61 13588 1.802218 1 0.827815 84.73356
DNAJB6