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Proceedings 2002 Proceedings 2002 XXVIII International Conference on Animal Genetics in Göttingen - Germany ISAG International Society for Animal Genetics Proceedings 2002 ISBN 3-00-010597-2 28th ISAG Conference 2002 Contents Invitation of Local Organizing Committee ................................................................... 2 Greeting from the Minister for Science and Culture .................................................... 3 Members of Local Organizing Committee................................................................... 4 Presentation of Guest Speakers ................................................................................. 5 Abstracts: Section A: Genome technologies................................................................. 26 Section B: MHC and Immunogenetic ........................................................... 41 Section C: Functional Genomics ................................................................. 47 Section D: Marker, Polymorphism and Biodiversity...................................... 78 Section E: Associations between markers and traits.................................. 147 Section F: Bioinformatics............................................................................ 178 Index of Authors...................................................................................................... 184 These proceedings are published under: ISBN 3-00-010597-2 1 28th ISAG Conference 2002 Georg-August-University City of Göttingen Dear colleagues, on behalf of the Local Organizing Committee, the International Society for Animal Genetics and the Georg-August-University of Göttingen, we would like to welcome all delegates and accompanying persons to the 28th International Conference on Animal Genetics in Göttingen. It is a great pleasure and honor for us that a conference of the ISAG will take place again in Göttingen after 17 years. The conference will be a unique blending of individual sessions and themes designed to provide you with an exceptional experience. The conference gathers a cadre of international experts in molecular genetics, molecular biology and related fields. These world-class presenters bring together a wealth of experience and knowledge for your benefit. Add to this the ability to share ideas and interact with a global network as well as to view the latest results in Animal Genetics from around the world and you have a conference that cannot be missed. The ideal forum to increase your personal knowledge and professional capabilities, the ISAG2002 conference will sure exceed your expectations. We wish you all pleasant, inspiring and motivating days in one of the oldest and most attractive University cities in Germany. Because of its central geographical position in Germany, Göttingen is also an extremely good starting point for pre- and post conference tours. We hope to see you in Göttingen at the International Conference and look forward to welcoming you to the "City of Science". Bertram Brenig Jan-Nikolaus Meyer 2 28th ISAG Conference 2002 Greeting from the Minister for Science and Culture of Lower Saxony, Thomas Oppermann Only 17 years ago the term Animal Genetics was in public at most connected with the attempt to increase the milk production through breeding. Today it can be found in almost any news media, related to a variety of issues. “Dolly”, the name of the first ever sheep that had been cloned is just as well the label for a milestone in the history of modern science. For weeks on end “Dolly” made headlines and triggered controversial discussions about genetic engineering and biological sciences. But another problem just as well represents the new requirements Animal Genetics is facing today: The public world-wide was alarmed when BSE spread among the cattle all over Europe. Suddenly, everybody was looking at this field of veterinary medicine, at Animal Genetics, as a source of hope and wishes as well as fear and worries. Considering this growth in importance, I am especially happy the 28th International Conference for Animal Genetics is taking place in Göttingen again after 17 years. Surely triggered by Animal Genetics, genetics has undergone quite an astonishing development during this time and is becoming one of the most important science branches in the 21st century. The genetic mapping of animals has progressed so far that in the years to come there could be enormous breakthroughs concerning the resistance to illnesses in animals and breeds. As well, the existing methods of animal breeding are going to change drastically due to the progress in Animal Genetics. The 28th International Conference for Animal Genetics is approaching the complexity of these issues from several sides. I am especially pleased that in addition to the participation of several veterinary and biological branches of science, bioethical aspects will be discussed as well. The general public will be expecting the new biological sciences to put up a critical reflection on this issue in particular. I’d like to thank the International Society for Animal Genetics (ISAG) for being host to this conference and the Institute of Veterinary Medicine and the Institute of Animal Breeding and Genetics of the Georg-August-Universität Göttingen and the Chairmen of the local organizing committee, Professor B. Brenig and Dr. Jan Meyer for preparing it and I wish all participants of this conference good progress and stimulating discussions. 3 28th ISAG Conference 2002 Local Organizing Committee 2002 Sabine Bramsmann Andreas Müller-Belecke Bertram Brenig Ina Pfeiffer Claus-Peter Czerny Henner Simianer Gabriele Hörstgen-Schwark Helge Täubert Christoph Knorr Clemens Wollny Ute Margan Secretary: Kaarina Hillmer Jan-N. Meyer Katharina Kurth Burchhard Möllers Treasurer: Monika Werst Institute of Animal Breeding and Genetics, Albrecht-Thaer-Weg 3 D-37075 Göttingen, Germany Institute of Veterinary Medicine, Groner Landstraße 2, D-37073 Göttingen, Germany Göttingens most famous monument „Gänseliesel“ 4 28th ISAG Conference 2002 Gue t ea ers Topic Prof. Dr. Adriano Aguzzi (Switzerland) The immunobiology of prion [email protected] diseases Prof. Dr. Choy Leong Hew (Singapore) Biotechnology and Transgenesis [email protected] in fish Dr. Bjorn Ingemarsson, PhD (Sweden) Comprehensive DNA analysis T [email protected] using Pyrosequencing M techno Prof Dr. Dr. Bernhard Irrgang (Getmany) Ethical Issues of Genetic [email protected] ManipuJation of Lifestock Prof Dr. Joan Lunney (USA) Can we use genomics to select for [email protected] healthier swine? Prof. Dr. Paula Schneider (Brazil) Biodiversity and Conservation in [email protected] Amazon Prof. Dr. Hans-J. Thiesen (Gennany) Proteornics hans-;[email protected] Dr. Alain Vignal (France) SNP teclmology [email protected] 8 28th ISAG Conference 2002 Adriano Aguzzi studied medicine at the University of Freiburg (Gennany) fonn 1980-1986. He received his Ph.D. in 1986. From 1986 to 1989 he was resident in Neuropathology at the University Hospital of ZUrich (Switzerland). Since 1997 he is full professor of Neuropathology and Director of the Institute of Neuropathology at the University of ZUrich. He is president of the Swiss Society of Neuropathology and member of severa] international Societies. His research interests are in the area of prion diseases with special focus on their pathogenesis. Choy Leong Hew is Head of the Department of Biological Sciences at the University of Singapore. He received his Ph.D. in 1970 at the University of British Columbia. From 1972 to 1974 he was a C.H. Best fellow at the Banting & Best Dept. of Medical Research of the University of Toronto (Canada). He was then working at the Memorial University of ~ Newfoundland as assistant professor until 1983. From 1983 to 1999 he was a visting professor at a variety of Universities in Canada and China. His main research areas are biology and biotechnology of antifreeze proteins, transgenic fish, molecular endocrinology and proteomics. Bjorn Ingemarsson is Director of Pyrosequencing AB's technical and scientific support function based m Uppsala. Prior to Jommg Pyrosequencing 3 years ago, he worked as a specialist in automated DNA analysis at Amersharn Pharmacia Biotech. He aquired his Ph.D. in plant physiology at the Stockholm University, where he thereafter continued research on the physiology, biochemistry and molecular biology of nitrogen assimilation in plants for several years. Bernhard Irrgang studied Philosophy, Theology and German Philology at the University of Wiirzburg (Germany), Passau (Germany) and Munich (Germany). He received his Ph.D. in Philosophy in 1982 and Theology in 1991. From 1982 to 1992 he worked at different Universities in Germany. Currently, he is Director of the Institute for Philosophy and the Centre for Interdisciplinary Technical Research at the Technical University of Dresden (Gennany). Bernhard Irrgang main interests are in the area of medical and technical ethics, consequences of technology and philosophy of technology. 9 Joan K. Lunney studied Chemistry at the JOM Hopkins University (Baltimore, USA) and received her Ph.D. on studies on the regulation of serum glycoprotein homeostasis in 1976. From 1976 to 1979 she was guest postdoctoral research worker in the Immunology Branch (NCI, NIH, Bethesda, MD). From 1983 until 1995 she was working in different position in the Helminthic Diseases Laboratory at the USDA, ARS (Beltsvi11e, MD). Since 1995 she is GM15 Research Leader and Supervisory Research Immunogeneticist at
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