Volume 81, No. 5 Supplement

Volume 81 November 2009 Number 5 h mrcnSceyo Tropical Medicine and Hygiene Final Program • Washington, DC, USA — 2009 The American Society of Final Program American Society of Tropical Medicine and Hygiene 58th Annual Meeting

ASTMH 58 Annual Meeting 2009

November 18–22, 2009 Marriott Wardman Park Washington, DC, USA

Supplement to The American Journal of Tropical Medicine and Hygiene ASTMH 58th Annual Meeting www.astmh.org

ASTMH Thanks the 58th Annual Meeting Supporters

Bill & Melinda Gates Foundation

Burroughs Wellcome Fund

International Association for Medical Assistance to Travelers

Novartis Pharma AG.

Novartis Vaccines

Pfi zer, Inc.

SCYNEXIS, Inc.

TechLab, Inc.

www.astmh.org

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5

ASTMH 58th Annual Meeting www.astmh.org

Table of Contents About the American Society of Tropical Medicine and Hygiene (ASTMH)

Annual Meeting Supporters ...... 3 The American Society of Tropical Medicine and Hygiene Program Changes ...... 7 (ASTMH), founded in 1903, is a worldwide organization of scientists, clinicians and program professionals whose mission Schedule-at-a-Glance ...... 8 is to promote global health through the prevention and control Related Organization Meeting Schedule ...... 19 of infectious and other diseases that disproportionately affl ict the global poor. Research, health care and education are the ASTMH Council, Committee and central activities of ASTMH members, whose work bridges Subgroup Meetings ...... 20 basic laboratory research to international fi eld work and clinics Offi cers and Councilors ...... 21 to countrywide programs.

Scientifi c Program Committee ...... 22 Specifi c ASTMH Goals Include: ASTMH Committees and Subgroups ...... 23 • Improving the health of people worldwide • Advancing research on tropical diseases ASTMH Headquarters ...... 25 • Fostering international scientifi c collaboration Affi liate Members...... 25 • Supporting career development in tropical medicine and global health Travel Awards ...... 26 • Educating medical professionals, policymakers and the Continuing Medical Education ...... 27 public about tropical medicine and global health • Promoting science-based policy regarding tropical Registration Hours ...... 28 medicine and global health Messages and Emergency Calls ...... 28 • Recognizing exceptional achievement in tropical medicine and global health Exhibits ...... 28 Employment Opportunities ...... 29 Join the American Society of Tropical Medicine and Hygiene Session Audio Recording ...... 30 Late Breaker Abstracts ...... 30 We invite you to join ASTMH and benefi t from membership in the premier international organization for scientists involved Meet the Professors ...... 30 in tropical medicine and global health. ASTMH provides a Special Events for Trainees ...... 31 forum for sharing scientifi c advances, exchanging ideas, foster- ing new research and providing professional education. See Clinical Session Guide ...... 32 the membership application on page 255. Poster Sessions ...... 33 Speaker Ready Room and Program Changes Audio-Visual Guidelines ...... 33 Times and/or locations of activities or sessions are subject to Travel Award, Fellowship and change. A Program Update is included in your registration Grant Recipients ...... 34 packet. Notices of schedule changes received after publication Future Annual Meeting Dates ...... 36 of the Program Update will be posted in the ASTMH registra- tion area. Exhibitor and Supporter Directory ...... 37 Detailed Program ...... 45 Questions

Abstract Author Index ...... 232 If you have any questions regarding the program or registra- Speaker and Session Chair Index ...... 251 tion, visit the ASTMH registration desk in the Salon Foyer on the fi rst fl oor. Membership Application ...... 255 Hotel Floorplan ...... 256

American Society of Tropical Medicine and Hygiene 111 Deer Lake Road, Suite 100 • Deerfi eld, IL 60015 USA Phone +1-847-480-9592 • Fax: +1-847-480-9282 • [email protected] • www.astmh.org

7 www.astmh.org Schedule-at-a-Glance Wednesday, November 18, 2009

Registration Desk Exhibit Hall Exhibit Hall B Salon 1 Salon 2 Salon 3 Room 8217 Room 8218 Room 8219 Salon Foyer A South First Floor First Floor First Floor First Floor First Floor First Floor First Floor Lower Level Lower Level

7 – 7:30 a.m.

7:30 – 8 a.m.

8 – 8:30 a.m.

8:30 – 9 a.m.

9 – 9:30 a.m.

9:30 – 10 a.m.

10 – 10:30 a.m.

10:30 – 11 a.m. Clinical Pre-Meeting 11 – 11:30 a.m. Course: Neglected ACAV Tropical SIE Meeting 11:30 a.m. – Noon Diseases

Noon – 12:30 p.m.

12:30 – 1 p.m. ACAV SIRACA 1 – 1:30 p.m. Meeting

1:30 – 2 p.m. Registration

2 – 2:30 p.m.

ACAV 2:30 – 3 p.m. SALS Meeting 3 – 3:30 p.m.

3:30 – 4 p.m.

4 – 4:30 p.m. Clinical ACME ACAV Student Group Council Council Council Reception Meeting Meeting 4:30 – 5 p.m. Meeting

5 – 5:30 p.m.

5:30 – 6 p.m.

6 – 6:30 p.m. 1 Opening Plenary Session and Awards Ceremony 6:30 – 7 p.m. P. 55

7 – 7:30 p.m.

7:30 – 8 p.m.

8 – 8:30 p.m. Opening Reception

8:30 – 9 p.m. Exhibits Open

9 – 9:30 p.m.

9:30 – 10 p.m.

8 Schedule-at-a-Glance www.astmh.org Wednesday, November 18, 2009

Capitol Balcony C Jackson Jefferson Johnson Taylor Truman Wilson AB Boardroom Second Floor Second Floor Second Floor Second Floor Second Floor Second Floor Second Floor First Floor

7 – 7:30 a.m.

7:30 – 8 a.m.

8 – 8:30 a.m.

8:30 – 9 a.m.

9 – 9:30 a.m.

9:30 – 10 a.m.

10 – 10:30 a.m.

10:30 – 11 a.m.

11 – 11:30 a.m. ASTMH Council 11:30 a.m. – Noon Meeting

Noon – 12:30 p.m.

12:30 –1 p.m. Global Health Working Young Young Young Young Young Group Investigator Investigator Investigator Investigator Investigator 1 – 1:30 p.m. Meeting Award Award Award Award Award Session A Session B Session C Session D Session E P. 47 P. 48 P. 50 P. 51 P. 53 1:30 – 2 p.m.

2 – 2:30 p.m.

2:30 – 3 p.m.

3 – 3:30 p.m.

3:30 – 4 p.m.

4 – 4:30 p.m. ACMCIP Council 4:30 – 5 p.m. Meeting

5 – 5:30 p.m.

5:30 – 6 p.m.

6 – 6:30 p.m.

6:30 – 7 p.m.

7 – 7:30 p.m.

7:30 – 8 p.m.

8 – 8:30 p.m.

8:30 – 9 p.m.

9 – 9:30 p.m.

9:30 – 10 p.m.

9 www.astmh.org Schedule-at-a-Glance Thursday, November 19, 2009

Exhibit Hall B Exhibit Hall A Salon 1 Salon 2 Salon 3 Delaware A Delaware B Virginia AB South Lower Level First Floor First Floor First Floor First Floor First Floor First Floor Lower Level

7 - 7:30 a.m.

7:30 - 8 a.m.

2 3 4 5 Global Health Symposium Symposium Scientifi c Cornerstone Diagnostic Q Fever Update Session 8 - 9:45 a.m. Symposium 1 Tests in VL P. 57 Malaria Drug P. 56 P. 56 Resistance Exhibits Open P. 57 9:30–10:30 Poster Session 9:45 - 10:15 a.m. Coffee Break A Set-Up 13 14 15 16 Symposium, Symposium Symposium Scientifi c Poster Global Funding New Therapy Math Models in Session 10:15 - Noon Session A in Finan Crisis in HAT & VL Malaria Control Malaria Viewing P. 62 P. 63 P. 63 Chemotherapy P. 64

Noon - 12:15 p.m. 24 12:15 - 12:30 p.m. Exhibit Hall Poster Session 25 Late 26 Late Open A Presentations Breakers Breakers Basic 12:30 - 12:45 p.m. Clinical Trop Science Mol Bio 12:45 - 1:15 p.m. Light Lunch Light Lunch Med P. 91 P. 91 P. 68 1:15 - 1:30 p.m. 29 30 31 32 33 34 Symposium Symposium Symposium Symposium Symposium Scientifi c Malaria Blood- President’s Climate SAFE Strategy Risks to Health Session 1:30 - 3:15 p.m. Stage Vaccine Malaria Change in Trachoma Care Workers Malaria Drug Exhibits Open P. 92 Initiative P. 92 P. 93 P. 93 Development 3–4 P. 92 P. 94

3:15- 3:45 p.m. Coffee Break

41 41A 42 43 44 45 Symposium Symposium Symposium Symposium Symposium Symposium Malaria Vaccine Child Mortality Changing Azithromycin Rapid Dx in Malaria Resist Poster 3:45 - 5:30 p.m. Immune & Diarrheal Dz Climate Mass Rx Low Resource Surveillance Session A Evasion P. 100 Geospatial P. 101 Setting P. 102 Viewing P. 99 Aspects Dz P. 101 P. 100

5:30 - 6 p.m.

52 6 - 6:45 p.m. Plenary II Soper Lecture P. 106

6:45 - 7 p.m.

7 - 7:30 p.m. Poster 7:15 p.m. Session A Satellite Dismantle 7:30 - 8 p.m. Symposium Anti-Malarial Drug 8 - 8:30 p.m. Development P. 106

8:30 - 9 p.m.

10 Schedule-at-a-Glance www.astmh.org Thursday, November 19, 2009

Virginia C Washington 1 Washington 2 Washington 3 Washington 4 Washington 5 Wilson AB First Floor Lower Level Lower Level Lower Level Lower Level Lower Level Second Floor

7 - 7:30 a.m.

7:30 - 8 a.m.

6 7 8 9 10 11 12 Scientifi c Symposium ACMCIP Symposium Scientifi c Symposium Symposium Session New Symposium Schisto in China Session Career Advances in 8 - 9:45 a.m. Ectoparasite Flaviviruses Gene Eliminating Mosquitoes Development 1 Tick Genome Borne Disease P. 59 Expression Transmission Vector Bio Epi 1 P. 61 Research P. 58 P. 60 P. 60 P. 60 P. 62

9:45 - 10:15 a.m.

17 18 19 20 21 22 23 Symposium Scientifi c Symposium Scientifi c Symposium Symposium Symposium Rickettsioses Session Gametocytes Session Vaccines Career Tsetse 10:15 - Noon in Asia Flavivirus & Malaria Kinetoplastida for Diarrheal Development II Physiology P. 64 Dengue 1 Transmission Molecular Bio Dz P. 67 Sleeping P. 65 P. 66 Immunology P. 67 Sickness P. 66 Control P. 68

Noon - 12:15 p.m.

12:15 - 12:30 p.m. 27 Meet the 28 Wellcome Professors A Grant Writing & 12:30 - 12:45 p.m. Cases Mentor 12:45 - 1:15 p.m. P. 91 P. 91

1:15 - 1:30 p.m.

1:30 - 3:15 p.m. 35 36 37 38 39 40 40A Symposium Scientifi c Symposium Scientifi c Scientifi c Symposium Symposium Pneumonia Session Wellcome Session Session ACME 1 Space Urban Typhoid Burden & Clin Trop Med I Trust Research Cestodes & ACMCIP Cell Repellents in Asia and Etiology P. 95 Capacity Intestinal Parasitology 1 Vector Control Africa P. 99 P. 95 Strength Nematodes P. 97 P. 98 P. 96 P. 96

3:15- 3:45 p.m.

46 47 48 49 50 51 Symposium Scientifi c Symposium Scientifi c Scientifi c Symposium Hantavrial Session Wellcome Session Session ACME II Space 3:45 - 5:30 p.m. Disease Clin Trop Med II Trust Global Filariasis ACMCIP Mol Repellents P. 102 P. 102 Workforce Pathology & Para I Vector Control Partnership Treatment P. 104 P. 105 P. 103 P. 104

5:30 - 6 p.m.

6 - 6:45 p.m.

6:45 - 7 p.m.

7 - 7:30 p.m.

7:30 - 8 p.m.

8 - 8:30 p.m.

8:30 - 9 p.m.

11 www.astmh.org Schedule-at-a-Glance Friday, November 20, 2009

Exhibit Hall B Exhibit Hall A Salon 1 Salon 2 Salon 3 Delaware A Delaware B Virginia AB South Lower Level First Floor First Floor First Floor First Floor First Floor First Floor Lower Level

7 - 7:30 a.m. 52A Gates EDD Strategy 7:30 - 8 a.m. P. 107

53 54 55 56 57 58 Symposium Scientifi c Symposium Symposium Symposium Symposium TB Malaria Session Careers in Trop Non-Typhoidal Rectal Control in 21st Eradication Malaria Bio & Med Research Salmonella in Artesunate in Century 8 - 9:45 a.m. Agenda Pathogenesis I P. 108 Africa Rural Africa P. 110 P. 107 P. 108 P. 109 P. 109 Exhibits Open 9:30 – 10:30

Poster Session 9:45 - 10:15 a.m. Coffee Break B Set-Up

67 68 70 70A Global Health Symposium Symposium Symposium Cornerstone Trop Med Brain Dz in Health of Poster Symposium II Research & Developing Travelers & 10:15 - Noon Session B P. 115 Promoting World Immigrants Viewing Human Rights P. 116 P. 116 P. 115

Noon - 12:15 p.m.

78 79 80 12:15 - 12:30 p.m. 77 Late Breakers ASTMH Late Breakers Poster Exhibit Hall in Clinical Journal in Basic Science Session B Open Tropical P. 144 Molecular Bio 12:30 - 12:45 p.m. Presentations Medicine P. 145 Light Lunch P. 144 Light Lunch 12:45 - 1:15 p.m. P. 121

1:15 - 1:30 p.m.

82 83 84 85 86 87 Symposium Symposium Symposium Symposium Symposium Symposium Acquired Clinical ACAV I Malaria Global Burden SCORE Schisto 1:30 - 3:15 p.m. Immunity in Group I Shope Fellows Pharmaco- of Anemia Consortium Malaria P. 146 P. 146 vigilance P. 147 P. 148 Exhibits Open P. 146 P. 147 3–4

3:15- 3:45 p.m. Coffee Break

94 95 96 97 98 99 Poster Symposium Symposium Symposium Symposium Symposium Symposium Session B Sporozoite Clinical Group II ACAV II Integrated Mgt Walter Reed Bioinformatics 3:45 - 5:30 p.m. Viewing Vaccine P. 152 History/ NTDs Research in P. 154 Malaria Discoveries P. 153 Vaccines P. 152 P. 152 P. 153

5:30 - 6 p.m.

105 Plenary III 6 - 6:45 p.m. Comm Fund Lecture P. 157

6:45 - 7 p.m.

7 - 7:30 p.m. Poster 7:15 p.m. Session B 106 7:30 - 8 p.m. Dismantle Symposium Malaria Genomics 8 - 8:30 p.m. BWF p. 157 8:30 - 9 p.m.

12 Schedule-at-a-Glance www.astmh.org Friday, November 20, 2009

Virginia C Washington 1 Washington 2 Washington 3 Washington 4 Washington 5 Wilson AB First Floor Lower Level Lower Level Lower Level Lower Level Lower Level Second Floor

7 - 7:30 a.m.

7:30 - 8 a.m.

59 60 61 62 63 64 65 Symposium Scientifi c Symposium Scientifi c Symposium Scientifi c Scientifi c Yellow Fever Session Human Subjects Session Chagas Dz Session Session Risk Mapping ACMCIP in Vector Bio Flavivirus Blood Banking Mosquitoes HIV in Tropics 8 - 9:45 a.m. P. 110 Immuno- Research Dengue II in U.S. Biochem/Mol P. 114 parasitology I P. 111 P. 112 P. 113 Bio & Molec P. 111 Gen I P. 113

9:45 - 10:15 a.m.

71 72 73 74 75 76 76A Symposium Scientifi c Scientifi c Scientifi c Symposium Symposium Scientifi c 30 Yrs of Session Session Session Making Impact NTD Control in Session CDC/KEMRI Schisto II Mosquitoes Flavivirus on Chagas Sub-Saharan Malaria 10:15 - Noon Collaboration Immunology- Vector Bio & Dengue III Disease Africa Molecular Bio P. 116 pathology Epi II P. 118 P. 119 P. 120 P. 120 P. 117 P. 118

Noon - 12:15 p.m.

12:15 - 12:30 p.m. 81 81A Meet the Case Studies 12:30 - 12:45 p.m. Professors B Global Cases Health P. 145 P. 145 12:45 - 1:15 p.m.

1:15 - 1:30 p.m.

88 89 90 91 93 Symposium Scientifi c Symposium Scientifi c Scientifi c Molec Pathogen Session Mosquito Session Session 1:30 - 3:15 p.m. Leishmaniasis ACMCIP Interaction Malaria Epi I Filariasis P. 148 Cell P. 149 P. 150 Molec Bio Parasitology II P. 151 P. 148

3:15- 3:45 p.m.

100 101 102 103 104 Symposium Symposium Symposium Symposium Scientifi c Antimalarials Anopheles Clean Water Drug Discovery Session 3:45 - 5:30 p.m. Market in Immunity to & Sanitation Human Malaria Africa Plasmodium Strategies Helminthiases Diagnosis P. 154 P. 155 P. 155 P. 155 P. 156

5:30 - 6 p.m.

6 - 6:45 p.m.

6:45 - 7 p.m.

7 - 7:30 p.m.

7:30 - 8 p.m.

8 - 8:30 p.m.

8:30 - 9 p.m.

13 www.astmh.org Schedule-at-a-Glance Saturday, November 21, 2009

Exhibit Hall B Exhibit Hall A Salon 1 Salon 2 Salon 3 Delaware A Delaware B Virginia AB South Lower Level First Floor First Floor First Floor First Floor First Floor First Floor Lower Level

7 - 7:30 a.m.

7:30 - 8 a.m.

107 108 109 110 111 112 Symposium Symposium Symposium Scientifi c Symposium Scientifi c Macrophages Global Dist of Cell Phones Session Rapid Session 8 - 9:45 a.m. in Parasite Falciparum & Improving Viruses I Diagnostic Tools Protozoa Immunity Malaria 2007 Human Health P. 159 in Theory & P. 160 P. 157 P. 158 P. 158 Practice Exhibits Open P. 159 9:30 – 10:30

Poster Session 9:45 - 10:15 a.m. Coffee Break C Set-Up

120 121 122 123 124 125 Scientifi c Scientifi c Symposium Symposium Symposium Scientifi c 26A Session Session Effi cacy of Vaccines in Assessing Session Poster Mosquitoes Viruses II Malaria Control Integrated Disease Pneumonia 10:15 - Noon Session C Biochem Mol P. 166 Programs Control of Elimination Respiratory TB Viewing Bio Mol P. 167 Helminth Dz P. 168 P. 168 Geneticss II P. 167 P. 165

Noon - 12:15 p.m.

133A 134 12:15 - 12:30 p.m. 133 Getting Your Salud Video Poster Exhibit Hall Work Cuba’s Role in Session C Open Published Global Health 12:30 - 12:45 p.m. Presentations P. 196 P. 196 Light Lunch Light Lunch 12:45 - 1:15 p.m. P. 173

1:15 - 1:30 p.m.

136 137 138 139 140 141 Symposium Symposium Scientifi c Scientifi c Symposium Symposium Remote Sustaining Session Session Arboviral Infxn Meds From 1:30 - 3:15 p.m. Sensing for Malaria Control ACMCIP Arthropods/ in Travelers Pharma’s Attic Vector Dz in Africa Immuno- Entomology P. 199 P. 200 Outbreaks P. 197 parasitology II P. 199 P. 197 P. 198

3:15- 3:45 p.m.

149 150 151 152 153 154 Poster Scientifi c Scientifi c Symposium Symposium Symposium Scientifi c Session C Session Session OneHealth New Trends Vector-Borne Session Viewing Schisto Malaria Control Initiative Anopheles Dz in People & Water, 3:45 - 5:30 p.m. Epi/Control & Treatment P. 207 darlingi Pets Sanitation & P. 205 Strategies P. 208 P. 208 Hygiene P. 206 P. 209

5:30 - 6 p.m.

6 - 6:45 p.m. 161 Plenary IV 6:45 - 7 p.m. Pres Address Business Mtg P. 214 7 - 7:30 p.m. Poster Session C 7:30 - 8 p.m. Dismantle

14 Schedule-at-a-Glance www.astmh.org Saturday, November 21, 2009

Virginia C Washington 1 Washington 2 Washington 3 Washington 4 Washington 5 Wilson A First Floor Lower Level Lower Level Lower Level Lower Level Lower Level Second Floor

7 - 7:30 a.m.

7:30 - 8 a.m.

113 114 115 116 117 118 119 Scientifi c Scientifi c Symposium Scientifi c Symposium Symposium Symposium Session Session Fetal Response Session Global Health Malaria Control Transitioning 8 - 9:45 a.m. Schisto NTDs in Placental Bacteriology & Mass Travel Indoor to Senior Vectors & P. 161 Malaria E Coli & Events Spraying Investigator Vector Bio P. 162 Cholera P. 164 P. 164 P. 165 P. 161 P. 163

9:45 - 10:15 a.m.

126 127 128 129 130 131 132 Symposium Symposium Symposium Symposium Symposium Scientifi c Scientifi c Education & Natural Malaria Control Epi of Vector- Communicable Session Session Training in Selection Bednets Borne Dz in the Dz in Post- Malaria Kinetoplastida 10:15 - Noon Global Health Impact in P. 170 Home Confl ict Settings Regulation Epi Dx Rx P. 169 Malaria P. 170 P. 171 of Cellular P. 172 P. 169 Immunity P. 171

Noon - 12:15 p.m.

135 12:15 - 12:30 p.m. Meet the Profs C Cases P. 196 12:30 - 12:45 p.m.

12:45 - 1:15 p.m.

1:15 - 1:30 p.m.

142 143 144 145 146 147 148 Symposium Symposium Scientifi c Scientifi c Scientifi c Scientifi c Symposium Integrated Mgt Spatial Scale of Session Session Session Session Workforce 1:30 - 3:15 p.m. of Malaria/Pneu/ Dengue Filariasis Malaria Epi II Malaria Malaria Bio & Migration Diarrhea P. 201 Control P. 202 Vaccines I Path II P. 205 P. 200 P. 201 P. 203 P. 204

3:15- 3:45 p.m.

155 156 157 158 159 160 160A Symposium Symposium Symposium Symposium Scientifi c Symposium Symposium Lymphedema Acute Dengue Monitoring Malaria Rapid Session Vivax Malaria Rotavirus Management 15-Year Insecticide Diagnostic Malaria P. 213 Vaccine Trials 3:45 - 5:30 p.m. P. 210 Experience Resistance Tests Functional P. 213 P. 210 P. 211 P. 211 Assessment Antibodies P. 212

5:30 - 6 p.m.

6 - 6:45 p.m.

6:45 - 7 p.m.

7 - 7:30 p.m.

7:30 - 8 p.m.

15 www.astmh.org Schedule-at-a-Glance Sunday, November 22, 2009

Marriott Foyer Salon 1 Salon 2 Salon 3 Delaware A Delaware B Virginia AB Virginia C Second Floor First Floor First Floor First Floor First Floor First Floor First Floor First Floor

7 - 7:30 a.m.

7:30 - 8 a.m.

163 164 165 166 167 168 Symposium Symposium Symposium Symposium Scientifi c Symposium Lit Update Severe Affordable Meds Improving IRB Session Malnutrition & Clin Trop Med Falciparum in Malaria Rx Processes Filariasis Enteric Dz in P. 214 Malaria P. 215 P. 216 Immunology Children 8 - 9:45 a.m. P. 215 P. 216 P. 217

9:45 - 10:15 a.m. Coffee Break

174 175 176 177 178 179 180 Symposium Scientifi c Scientifi c Symposium Symposium Scientifi c Symposium Cross Border Session Session Habitat Loss Dendritic Cells Session Childhood Travel Bugs Clin Trop ACMCIP Effects & Dz in Parasite Malaria Pneumonia in 10:15 - Noon P. 222 Med III Molecular Transmission Immunity Mosquitoes & Developing P. 222 Parasitology II P. 224 P. 225 Prevention World P. 223 P. 225 P. 226

Noon - 12:15 p.m.

12:15 - 12:30 p.m.

12:30 - 12:45 p.m.

12:45 - 1:15 p.m.

1:15 - 1:30 p.m.

1:30 - 3:15 p.m.

3:15- 3:45 p.m.

3:45 - 5:30 p.m.

5:30 - 6 p.m.

6 - 6:45 p.m.

6:45 - 7 p.m.

7 - 7:30 p.m.

7:30 - 8 p.m.

16 Schedule-at-a-Glance www.astmh.org Sunday, November 22, 2009

Washington 1 Washington 2 Washington 3 Washington 4 Washington 5 Washington 6 Balcony Lower Level Lower Level Lower Level Lower Level Lower Level Lower Level B

7 - 7:30 a.m.

7:30 - 8 a.m.

169 170 171 172 173 173A Scientifi c Scientifi c Symposium Symposium Symposium Scientifi c Session Session Forest Flu in Hygiene Session ASTMH Mosquitoes Flavivirus Dengue Developing Behavior Malaria Council Insecticide West Nile P. 219 World & Health Vaccines II 8 - 9:45 a.m. Meeting Resistance & P. 218 P. 220 Outcomes P. 221 Control P. 220 P. 217

9:45 - 10:15 a.m.

181 182 183 184 185 186 Symposium Scientifi c Scientifi c Scientifi c Scientifi c Symposium Anopheles Session Session Session Session Babesia gambiae Flavivirus Schisto Global Health Bacteriology P. 230 10:15 - Noon Population P. 227 Biochem/Molec P. 228 Diarrhea Genomics Bio Enteric Fever P. 226 P. 228 Leptospirosis P. 229

Noon - 12:15 p.m.

12:15 - 12:30 p.m.

12:30 - 12:45 p.m.

12:45 - 1:15 p.m.

1:15 - 1:30 p.m.

1:30 - 3:15 p.m.

3:15- 3:45 p.m.

3:45 - 5:30 p.m.

5:30 - 6 p.m.

6 - 6:45 p.m.

6:45 - 7 p.m.

7 - 7:30 p.m.

7:30 - 8 p.m.

17 www.astmh.org ASTMH 58th Annual Meeting

18 Related Organization Meeting Schedule www.astmh.org Note: These meetings are by invitation only.

Monday, November 16 Pfi zer Meeting Room Thursday, November 19 Johns Hopkins Malaria Seattle Biomedical Research Balcony A Pfi zer Meeting Room Research Institute Reunion Institute Malaria Advisory 7 a.m. - 7 p.m. Balcony A Balcony B Board Meeting 7 a.m. - 7 p.m. 5:30 p.m. - 7 p.m. Room 8222 Bill & Melinda Gates 8 a.m. - 5 p.m. Foundation Meeting Novartis Pharma AG. WRAIR Commander’s Balcony D Meeting Room Reception Liverpool School of Tropical 7 a.m. - 7 p.m. Tyler Delaware AB Medicine AWOL Consortium 7 a.m. - 7 p.m. 7:15 p.m. - 9:15 p.m. Winter Meeting 2009 USAMMDA Meeting Room Balcony B Room 8216 Bill & Melinda Gates Saturday, November 21 8 a.m. - 6 p.m. 9 a.m. - 9 p.m. Foundation Meeting Pfi zer Meeting Room Balcony D Balcony A Novartis Vaccines Bangladesh Cholera Behavior 7 a.m. - 7 p.m. 7 a.m. - 7 p.m. Update/Ad Board Change Team Meeting Balcony A Room 8211 International Society for Novartis Pharma AG. Meeting 2 p.m. - 6 p.m. 9 a.m. - 5 p.m. Infectious Diseases - NTD Room Program Committee Meeting Tyler Tuesday, November 17 Investigators’ Meeting - Room 8217 7 a.m. - 7 p.m. Update on U.S./Thai 8:30 a.m. - 10:15 a.m. Novartis Pharma AG. Collaborations on Dengue Meeting Room Bill & Melinda Gates Research USAMMDA Meeting Room Foundation Meeting Tyler Room 8212 7 a.m. - 7 p.m. Room 8216 Balcony D 9 a.m. - 5 p.m. 9 a.m. - 9 p.m. 7 a.m. - 7 p.m. Novartis Vaccines Seventh Annual IGGI Meeting Update/Ad Board PATH Malaria Vaccine USAMMDA Meeting Room Ethan Allen - Wardman Tower Initiative Room 8216 Balcony A, Room 8218, 9 a.m. - 1 p.m. Capitol Boardroom Wilson C 9 a.m. - 9 p.m. 7 a.m. - 10 p.m. 6 p.m. - 9 p.m. MR4 Science Advisory Global TravEpiNet Consortium Committee Meeting Liverpool School of Tropical SCYNEXIS, Inc. Meeting Meeting Balcony B Wilson AB Balcony B Medicine AWOL ESAC and MC 10 a.m. - 3 p.m. Winter Meeting 2009 6 p.m. - 10 p.m. 12:15 p.m. - 1:15 p.m. Room 8219 Consortium for Parasitic 9 a.m. - 5 p.m. Friday, November 20 London School of Hygiene Drug Development Scientifi c and Tropical Medicine Alumni Advisory Board Pfi zer Meeting Room Seventh Annual IGGI Meeting Balcony A Reception Capitol Boardroom Balcony C Ethan Allen - Wardman Tower 11 a.m. - 1:30 p.m. 7 a.m. - 7 p.m. 9 a.m. - 6 p.m. 7:30 p.m. - 10 p.m. Novartis Pharma AG. CDC International Emerging Sunday, November 22 Consortium for Parasitic Infections Program Meeting Room Drug Development Governance Thomas Paine-Wardman Tower Tyler Bill & Melinda Gates Council Noon - 5 p.m. 7 a.m. - 7 p.m. Foundation Meeting Jackson Balcony D Noon - 5 p.m. International Society of Travel Bill & Melinda Gates 7 a.m. - 5 p.m. Medicine GeoSentinel Site Foundation Meeting Bill & Melinda Gates Directors Meeting Balcony D Pfi zer Meeting Room Foundation Integrated Room 8210 7 a.m. - 7 p.m. Balcony A NTD Meeting 1 p.m. - 5 p.m. 7 a.m. - Noon Nathan Hale - Wardman Tower USAMMDA Meeting Room Noon - 6 p.m. Medicines for Malaria Venture Room 8216 Novartis Pharma AG. CRIMALDDI Meeting 9 a.m. - 9 p.m. Meeting Room Medicines for Malaria Venture Wilson C Tyler CRIMALDDI Meeting 1 p.m. - 6 p.m. Novartis Pharma AG. Meeting 7 a.m. - Noon Washington 6 Wilson AB 1 p.m. - 6 p.m. PATH Malaria Vaccine 7 p.m. - 9 p.m. International Society of Travel Initiative LaTrobe MSP2 Medicine Executive Board Wednesday, November 18 Clinical Trial sanofi -aventis Groupe Meeting Meeting Bill & Melinda Gates Ethan Allen - Wardman Tower Wilson C Room 8211 Foundation Integrated 3 p.m. - 5 p.m. 5 p.m. - 8 p.m. 8 a.m. - 5 p.m. NTD Meeting Nathan Hale - Wardman Tower Novartis Vaccines Internal PATH Malaria Vaccine UC Davis Activity Space 7 a.m. - 6 p.m. Briefi ng Meeting Initiative AMA-1 Investigators Room 8210 Balcony C Consortium Noon - 6 p.m. Novartis Pharma AG. 4 p.m. - 6 p.m. Virginia C Meeting Room 5:45 p.m. - 9 p.m. Tyler 7 a.m. - 7 p.m.

19 www.astmh.org ASTMH Council, Committee and Subgroup Meetings Wednesday, November 18 Friday, November 20

ASTMH Council Meeting ASTMH Journal Editorial Board Meeting Wilson AB Wilson C 8 a.m. - 3 p.m. 7 a.m. - 8 a.m. ACAV SIE Subcommittee Meeting Clinical Group Past Presidents Meeting Room 8219 Room 8212 11 a.m. - Noon 7 a.m. - 8 a.m. ACAV SIRACA Subcommittee Meeting Education Committee Meeting Room 8219 Room 8211 Noon - 2 p.m. 7 a.m. - 8 a.m. ASTMH Global Health Working Group Meeting CME/Courses Committee Meeting Balcony C Room 8211 Noon - 2 p.m. 12:15 p.m. - 1:15 p.m. ACAV SALS Subcommittee Meeting Public Relations Committee Meeting Room 8219 Room 8212 2 p.m. - 3:30 p.m. 12:15 p.m. - 1:15 p.m. ACAV Council Meeting Room 8219 Saturday, November 21 3:30 p.m. - 5:30 p.m. ACMCIP Council Meeting Scientifi c Program Committee Meeting Capitol Boardroom Balcony B 3:30 p.m. - 5:30 p.m. 7 a.m. - 8 a.m. ACME Council Meeting Web Site Committee Meeting Room 8217 Room 8217 3:30 p.m. - 5:30 p.m. 7 a.m. - 8 a.m. Clinical Group Council Meeting ASTMH Past Presidents Meeting Room 8218 Balcony C 3:30 p.m. - 5:30 p.m. 7 a.m. - 8 a.m. Young Investigator Award Committee Meeting Membership Committee Meeting Jackson Room 8217 3:30 p.m. - 5 p.m. 12:15 p.m. - 1:15 p.m. Certifi cate Exam Committee Meeting Thursday, November 19 Room 8212 12:15 p.m. - 1:15 p.m. ASTMH Diploma Course Directors Meeting Room 8212 Sunday, November 22 7 a.m. - 8 a.m. Public Policy and Advocacy Leadership Committee Meeting ASTMH Council Meeting Room 8211 Balcony B 7 a.m. - 8 a.m. 7:30 a.m. - 9:30 a.m. Clinical Group Education Curriculum Meeting Room 8217 7 a.m. - 8 a.m. Meeting Room Sign-Up Burroughs Wellcome Fund/ASTMH Fellowship Rooms 8218 and 8219 on the fi rst fl oor are designated Committee Meeting for committee meetings and other group meetings. Jackson Meeting room reservations are available on a fi rst- Noon - 2 p.m. come, fi rst-served basis. Use the sign-up sheets Certifi cate Exam Executive Committee Meeting located outside these rooms to reserve meeting time Room 8217 for your group. 12:15 p.m. - 1:15 p.m. ASTMH Subgroup Tables Clinical Standards and Treatment Guidelines Committee Room 8212 Visit the American Committee of Medical Entomology 12:15 p.m. - 1:15 p.m. (ACME) and the American Committee on Arthropod- Borne Viruses (ACAV) information tables in the exhibit hall to learn about their programs and activities.

20 ASTMH 58th Annual Meeting www.astmh.org

Offi cers

President Thomas Wellems

President-Elect Edward Ryan

Immediate Past President Claire Panosian

Secretary-Treasurer Jonathan Berman

Executive Director Sally Finney

Councilors

Joel Breman Steve Higgs James Hughes Regina Rabinovich Frank Richards Rick Steketee Scott Weaver Mary Wilson

Chair, Scientifi c Program Committee Christopher King

Editor, American Journal of Tropical Medicine and Hygiene James Kazura

Editors, Tropical Medicine and Hygiene News William Collins and Geoffrey Jeffery

Web Site Editor Jonathan Mayer

Advisor Peter Weller

American Society of Tropical Medicine and Hygiene 111 Deer Lake Road, Suite 100 Deerfi eld, IL 60015 USA Phone +1-847-480-9592 Fax: +1-847-480-9282 [email protected] www.astmh.org

21 www.astmh.org ASTMH Scientifi c Program Committee Christopher King, Chair Career Development/Education Kinetoplastida Opportunistic and Anaerobic Chair: Sarah Volkman Chair: Diane McMahon-Pratt Protozoa Michele Barry Nisha Garg Chair: Thaddeus Graczyk Steve Higgs Hira Nakhasi Beth Kirkpatrick Anne McCarthy Lynn Soong Barbara Mann Upinder Singh Clinical Tropical Medicine Late Breakers in Clinical Tropical Chair: Robert Gasser Medicine Pneumonia, Respiratory Infections Jean-Paul Chretien Barbara Herwaldt and Tuberculosis John Gawoski Jason Maguire Chair: Abdullah Brooks Davidson Hamer Rob Breiman Larry Laughlin Late Breakers in Basic Science/ Davidson Hamer Jason Maguire Molecular Biology Keith Klugman Alan Spira Greg Ebel Joe Vinetz Stefan Kappe Schistosomiasis-Helminths Chair: Evan Secor Bacteriology Malaria Miguel Stadecker Chair: Ed Ryan Chair: Carol Sibley David Williams James Hughes Johanna Daily Regina LaRocque Mary Hamel Tick-Louse-Flea-Mite-Borne Diseases Chandy John Chair: Stephen Dumler Entomology Sanjai Kumar Bob Lane Chair: William Black Miriam Laufer Sam Telford Kate Aultman Myaing Nyunt Hilary Ranson Laurence Slutsker Tropical HIV and Co-Infections David Severson Joe Vinetz Chair: Jean Nachega Sarah Volkman Elizabeth Barnett Filariasis Kim Williamson Davidson Hamer Chair: Amy Klion Yimin Wu Rocio Hurtado Peter Fischer Edward Mitre Meet the Professors Virology Frank Richards Davidson Hamer Chair: Rebeca Rico-Hesse Steven Williams Carol Blair Molecular Parasitology Scott Halstead Global Health Chair: Sarah Volkman George Ludwig Chair: Michele Barry David Abraham Julia Lynch Don Burke John Adams Kate Rubins Wil Milhous Daniel Carucci Michael Turell Jonathan Ripp Brian Cooke Don Harn Water, Sanitation and Hygiene Intestinal and Tissue Helminths, Peter Kima Chair: Pavani Ram Cestodes Barbara Mann Eric Mintz Chair: A. Clinton White Diane McMahon-Pratt Christine Moe David Abraham Peter Melby Mark Eberhard Evan Secor Peter Kern Joe Vinetz David Williams Kim Williamson

22 ASTMH Committees and Subgroups www.astmh.org

Archives Corporate Liaison Donald Burke (2008-2010), Chair Thomas Monath (2007-2009), Chair Bradley Connor (2008-2010); Jaco Smit (2009-2011) Audit/Finance Josh Berman (2009-2011), Chair Continuing Medical Education/Courses Committee Sally Finney; Ed Ryan; Peter Weller Alan Magill (2008-2010), Chair Tim Endy (2009-2011), CME Liaison Awards Jonathan Berman (2007-2009); Dan Carucci (2008-2010); Myron Levine (2007-2009), Chair Christina Coyle (2009-2011); David Hill (2008-2010); Eric Kent Campbell (2008-2010); Claire Panosian (2009-2011) Houpt (2009-2011); Christopher King (2009-2011); Desiree LaBeaud (2009-2011); Richard Pearson (2009-2011); Ed Benjamin H. Kean Traveling Fellowship in Tropical Ryan (2007-2009) Medicine Christopher Plowe, Chair (2007-2009) Credentialing Committee Colette Kean (Honorary); Myaing Nyunt (2008-2010); Larry Laughlin (2009-2011), Chair William Stauffer (2009-2011); A. Clinton White (2009-2011); David Freedman (2007-2009); David Hill (2008-2010); Martin Wolfe (2007-2009) Christopher Karp (2009-2011); Jay Keystone (2007-2009); Christopher King (2008-2010); Herbert Tanowitz (2009-2011) Burroughs Wellcome Fund-ASTMH Fellowship Terrie Taylor (2007-2009), Chair Editorial Board, American Journal of Tropical Medicine and Stephen Calderwood (2007-2009); Ravi Durvasula (2008- Hygiene 2010); Richard Guerrant (2009-2011); Regina LaRocque David Abraham; John Barnwell; Michael Cappello; William (2008-2010); Victoria McGovern (standing); Peter Weller Collins; Hector Garcia; James Hughes; Jay Keystone; Philip (2009-2011) LoVerde; Steven Meshnick; Thomas Nutman; Rebeca Rico- Hesse; Philip Rosenthal; Terrie Taylor; Robert Tesh; David Certifi cate Examination Walker; Editorial Staff: James Kazura, Chair (Editor-in- Susan McLellan, Chair (2007-2009) Chief); McWilson Warren (Emeritus Editor); Joe Vinetz Lin Chen (2007-2009); Jovita Fernandez (2008-2010); David (Associate Editor); Cathi Siegel (Managing Editor); Laura Freedman (2009-2011); Gregory Juckett (2007-2009); Lisa Buckley (Editorial Assistant); Allen Hightower (Statistical Keep (2008-2010); Ali Khan (2009-2011); Victor Kovner Editor); Section Editors: J. Kevin Baird; J. Stephen Dumler; (2007-2009); Walter Kuhn (2008-2010); James Maguire Diane McMahon-Pratt; Tom Scott; Scott Weaver; Clinical (2009-2011); Bonnie Smoak (2007-2009); William Stauffer Group Editor: James Maguire (2008-2010); A. Clinton White (2009-2011) Education Certifi cate Exam Executive Committee Steve Higgs, Chair (2008-2010) James Maguire (2008-2010), Chair Noah Craft (2007-2009); Hector Gorbea (2008-2010); Laura Tom Wellems (2009); Josh Berman (2009-2011); Patricia Harrington (2009-2011); Risa Hoffman (2007-2009); Charles Joyce (2007-2009); Larry Laughlin (2009-2011); Joe Vinetz McGee (2008-2010); Victoria McGovern (2009-2011); (2009); Susan McLellan (2007-2009) Claire Panosian (2007-2009); Sarah Volkman (2008-2010); Steve Wikel (2009-2011); Jack Woodall (2007-2009); Peter Clinical Standards and Treatment Guidelines Zimmerman (2008-2010) Ed Ryan, Chair (2010-2012) Naomi Aronson (2010-2012); Josh Berman (2010-2011); Fundraising Philip Coyne (2010-2012); Johanna Daily (2010-2011); Peter Weller (2009-2011), Chair David Freedman (2010-2012); Robert Gasser (2010-2011); Michele Barry (2007-2009); Stephen Hoffman (2008-2010); Hector Gorbea (2010-2012); David Hill (2010-2011); Eric Peter Hotez (2009-2011); James Kazura (2007-2009); Tom Houpt (2010-2012); Rocio Hurtado (2010-2011); Chandy Monath (2008-2010); William Petri (2009-2011); Dyann John (2010-2012); Kevin Kain (2010-2011); James Maguire Wirth (2007-2009) (2010-2012); Jean Nachega (2010-2011); Monica Parise (2010-2011); William Stauffer (2010-2011); Joseph Vinetz Gorgas Memorial Institute Research Award (2010-2012); Mary Wilson (2010-2011) Kathryn Aultman (2008-2010), Chair Patricia Dorn (2008-2010); Ynes Ortega (2009-2011); Jorge Commemorative Fund Lectureship Osorio (2007-2009); Rebeca Rico-Hesse (2008-2010); Tom Tom Wellems, Chair (2009) Yuill (2009-2011)

Communications Award Honorary Membership Claire Panosian, Chair (2008-2010) Tom Monath, Chair (2008-2010) John Donnelly (2008-2010); Michael Leahy (2008-2010); John David (2008-2010); Frank Neva (2007-2009); William James Maguire (2009-2011); Frank Richards (2009-2011) Petri (2009-2011)

23 www.astmh.org ASTMH Committees and Subgroups

International Federation of Tropical Medicine Robert E. Shope International Fellowship Representative Charles Calisher (2009-2011), Chair Don Krogstad Barry Beaty (2007-2009); Donald Burke (2008-2010); George Ludwig (2009-2011); Barry Miller (2007-2009); Philip Russell Lecture (Fred L. Soper and Charles F. Craig) (2008-2010); Richard Shope (2009-2011); Peter Weller (2007- Robert Tesh (2008-2010), Chair 2009); Ann Powers (Ex-offi cio) Donald Burke (2007-2009); David Freedman (Gorgas representative, standing); Peter Hotez (2008-2010); William Scientifi c Program Petri (2009-2011) Christopher King, Chair (2009-2010)

Membership Travel Awards Josh Berman (2009-2011), Chair James LeDuc (2009-2011), Chair Charles McGee (2007-2009); Claire Panosian (2008-2010); Bruce Christensen (2009-2011); Mark Eberhard (2007-2009); Sarah Volkman (ACMCIP president); Ann Powers (ACAV James Maguire (2008-2010); Dan Milner (2009-2011); Terrie chair); Jefferson Vaughan (ACME chair); Joe Vinetz Taylor (2007-2009); Eileen Villasante (2008-2010); Joe Vinetz (Clinical Group president) (2009-2011); Sarah Volkman (2008-2010)

Newsletter Editorial Board Update Course in Clinical Tropical Medicine and Travelers’ William Collins, Editor; Geoffrey Jeffery, Editor Health Kathryn Aultman; Latha Rajan; Mitzi Sereno; Karl Western Christina Coyle, Co-Chair (2009-2011); Eric Houpt, Co-Chair (2009-2011) Nominations Claire Panosian (2009-2010), Chair Web Site Committee Dan Bausch (2008-2009); Brenda Beerntsen (2009-2010); Jonathan Mayer (2009), Chair John Donelson (2009-2010); Mary Hamel (2008-2009); Kathryn Aultman (2007-2009); Stephen Cunnion (2008-2010); Anthony James (2009-2010); Diane McMahon-Pratt (2009- Ken Dardick (2009-2011); Akhil Vaidya (2009-2011); Dawn 2010); Thomas Nutman (2008-2009); Carol Sibley (2009- Wesson (2007-2009); Jack Woodall (2008-2010) 2010); Gary Weil (2008-2009); Clinton White (2008-2009) Young Investigator Award Pfi zer Centennial Travel Award Peter Zimmerman (2007-2009), Chair Joe Vinetz (2009-2011), Chair Kate Aultman (2007-2009); Lyric Bartholomay (2009-2011); Michael Cappello (2007-2009); David Fidock (2008-2010); Brenda Beerntsen (2008-2010); Roland Cooper (2009-2011); Diane McMahon-Pratt (2009-2011); Thomas Moore (2007- Stephen Davies (2007-2009); Rick Fairhurst (2008-2010); 2009); Sarah Volkman (2008-2010) Brian Grimberg (2009-2011); Julian Hillyer (2009-2011); Nick Komar (2007-2009); Sanjai Kumar (2008-2010); Miriam Program Certifi cation Laufer (2009-2011); Ed Mitre (2007-2009); Christine Petersen James Maguire (2008-2010), Chair (2008-2010); Julian Rayner (2008-2010); Daniel Tisch (2009- Michele Barry (2007-2009); David Freedman (2008-2010); 2011); Joe Vinetz (2007-2009); Patricia Wilkins (2009-2011); Richard Guerrant (2009-2011); Rocio Hurtado (2007-2009); David Williams (2008-2010); Yimin Wu (2009-2011) James Kazura (2008-2010); Donald Krogstad (2009-2011); Larry Laughlin (2007-2009); Anne McCarthy (2008-2010); Alan Spira (2009-2011); Peter Weller (2007-2009) American Committee of Medical Entomology (ACME) Public Policy and Advocacy Leadership Jefferson Vaughan, Chair Kent Campbell (2007-2009), Chair Josh Hartzell (2009-2011); James Maguire (2007-2009); American Committee on Arthropod-Borne Viruses (ACAV) Larry Slutsker (2008-2010); Sarah Volkman (2007-2009) Ann Powers, Chair

Public Relations Clinical Group (American Committee on Clinical Tropical Tom Wellems and Sally Finney, Co-Chairs Medicine and Travelers’ Health – ACCTMTH) Kent Campbell; Steve Higgs; James Kazura; Christopher Joe Vinetz, President King; Jonathan Mayer; Ann Powers; Jeff Vaughan; Joe Vinetz American Committee of Molecular, Cellular and Immunoparasitology (ACMCIP) Sarah Volkman, President

24 ASTMH Committees and Subgroups www.astmh.org

ASTMH Headquarters Staff

Sally Finney, Executive Director

Bill Chandler, Accountant

Annie Cox, Administrator

Judy DeAcetis, Administrative Director

Buffy Finn, Member Services Administrator

Jill Hronek, Communications Director

Matthew Lesh, Communications Manager

Lyn Maddox, Conference Director

Kim Santos, Conference Administrator

ASTMH Affi liate Members

Donor TechLab Inc.

Contributor Massachusetts General Hospital Merck Research Laboratories

Affi liate Membership

Affi liate membership is an opportunity for a company, corporation, foundation or other type of organization to support ASTMH and its mission. Affi liate members designate one individual to serve as the main contact and receive society mailings. Affi liate membership benefi ts include:

• Recognition in ASTMH publications and at the annual meeting • Discounts on annual meeting exhibit space fees, journal advertising rates and list rentals

Affi liate membership is available at the Patron, Donor and Contributor levels. Contact ASTMH headquarters for details or to request an application.

25 www.astmh.org 2009 Travel Awards Supported with funding from the Bill & Melinda Gates Foundation

Yaw Afrane Iqbal Elyazar Rosalind Howes Hamma Maiga Kenya Medical Research Eijkman-Oxford Clinical University of Oxford MRTC Institute Research Unit Oxford, United Kingdom Bamako, Mali Kisumu, Kenya Jakarta Pusat, Indonesia Abstract 184 Abstract 149 Abstract 679 Abstract 185 Anam Javed Swati Mandal Some Anyirekun Fabrice Mofolusho Falade University of Arizona School of Life Sciences IRSS-Bobo National Centre for Genetic Tucson, Arizona New Delhi, India Bobo-Dioulasso, Burkina Faso Engineering and Biotechnology Abstract 231 Abstract 36 Abstract 377 (BIOTEC) Pathumthani, Thailand Adela Jiram Dairo Marin Samuel Anyona Abstract 173 Institute for Medical Research Centro Internacional de University of New Mexico/ Kuala Lumpur, Malaysia Entrenamiento e Investigaciones KEMRI Rafael Maciel Freitas Abstract 1113 Medicas Kisumu, Kenya Oswaldo Cruz Foundation Cali, Colombia Abstract 140 Rio de Janeiro, Brazil Regina Joice Abstract 253 Abstract 251 Harvard School of Public Health Albert Auguste Boston, Massachusetts, USA Richard Maude University of the West Indies Jose Gaudier Abstract 143 Wellcome Trust Mahidol-Oxford St. Augustine, Trinidad and University of Puerto Rico Tropical Medicine Research Unit Tobago San Juan, Puerto Rico Basile Kamgang Bangkok, Thailand Abstract 689 Abstract 385 Organisation de Coordination Abstract 135 pour la lutte contre les Endémies Joanne Baker Najia Ghanchi en Afrique Centra Alberto Mendoza Australian Army Malaria Aga Khan University Yaounde, Cameroon National Institute of Health Institute Karachi, Pakistan Abstract 957 Lima, Peru Enoggera, Queensland, Australia Abstract 177 Abstract 606 Abstract 860 Hae Ji Kang Simon Glover Pacifi c Center for Emerging Atis Muehlenbachs James Bangura University of Malawi Infectious Diseases Research University of Washington Ministry of Health and Blantyre, Malawi Honolulu, Hawaii, USA Seattle, Washington, USA Sanitation Abstract 1041 Abstract 686 Abstract 136 Kenema, Sierra Leone Abstract 727 Vinay Gupta Stephan Karl Cyrille Ndo University of California at San The University of Western Organisation de Coordination Jun Cao Francisco Australia pour la lutte contre les Endémies Jiangsu Institute of Parasitic San Francisco, California, USA Perth, Western Australia, en Afrique Centra Diseases Abstract 895 Australia Yaounde, Cameroon Wuxi, People’s Republic of Abstract 186 Abstract 720 China Lina Gutiérrez Builes Abstract 372 Universidad de Antioquia Adama Keita Quyen N. Nguyen Medellin, Colombia Centre pour le Developpement des Oxford University Clinical Andrea Conroy Abstract 958 Vaccins – Mali Research Unit, Hospital for University of Toronto Bamako, Mali Tropical Diseases Toronto, Ontario, Canada Whitney Harrington Abstract 63 Ho Chi Minh Abstract 1045 University of Washington/ City, Vietnam Seattle Biomedical Research David Langoi Abstract 1109 Maria Dantur Juri Institute Institute of Primate Research Universidad Nacional de Seattle, Washington, USA Nairobi, Kenya Abdisalan Noor Tucumán Abstract 1040 Abstract 279 Kenya Medical Research San Miguel de Tucumán - Institute/Wellcome Trust Tucumán, Argentina Md. Jahangir Hossain Tatjana Keesen de Souza Research Programme Abstract 960 ICDDR-B Lima Nairobi, Kenya Dhaka, Bangladesh Federal University of Minas Abstract 1028 Abstract 725 Gerais Belo Horizonte, Brazil Abstract 37

26 2009 Travel Awards www.astmh.org Supported with funding from the Bill & Melinda Gates Foundation

Michael Odera Robert Opoka Richard Ssekitoleko Esther Volper Kenya Medical Research Makerere University Mbarara University University of Hawaii Institute Kampala, Uganda Mbarara, Uganda Honolulu, Hawaii, USA Kisumu, Kenya Abstract 863 Abstract 322 Abstract 91 Abstract 201 Renzo Perales Argon Steel Catherine Westbrook Bilha Ogola Instituto de Medicina Tropical University of Hawaii Florida Medical Entomology Lab Moi University “Alexander von Humboldt” Honolulu, Hawaii, USA Vero Beach, Florida, USA Kisumu, Kenya Lima, Peru Abstract 88 Abstract 243 Abstract 203 Abstract 127 Sivapong Sungpradit Kayla Wolofsky Lilian Ogonda Panote Prapansilp Chulalongkorn University University of Toronto Kenya Medical Research Wolfson College Bangkok, Thailand Toronto, Ontario, Canada Institute (KEMRI)/Walter Oxford, United Kingdom Abstract 117 Abstract 343 Reed Project (WRP) Abstract 137 Kisumu, Kenya Marco Tovar Abstract 202 Wasiq Rawasia Universidad Peruana Cayetano 2009 Aga Khan University Heredia American Emelda Okiro Karachi, Pakistan Lima, Peru Committee KEMRI-Wellcome Trust Abstract 176 Abstract 734 Research Programme of Medical Nairobi, Kenya Melissa Riedesel Cristian Valencia Entomology Abstract 192 University of Minnesota von Humboldt Institute of (ACME) Minneapolis, Minnesota, USA Tropical Medicine Evans Okoth Abstract 1031 Lima, Peru Travel University of New Mexico/ Abstract 479 Awards KEMRI Amy Savage Kisumu, Kenya Yale University Nicolas Veland Lauren Cator Abstract 141 New Haven, Connecticut, USA Universidad Peruana Cayetano Cornell University Abstract 488 Heredia Ithaca, New York, USA Richard Omore Lima, Peru Abstract 590 Kenya Medical Research Karlee Silver Abstract 492 Institute, U.S. Centers for University of Toronto Win Surachetpong Disease Control and Prevention Toronto, Ontario, Canada University of California at Davis Kisumu, Kenya Abstract 139 Davis, California, USA Abstract 1141 Abstract 1110

Continuing Medical Education Accreditation Full Disclosure Policy Affecting CME Activities The American Society of Tropical Medicine and Hygiene Consistent with ASTMH policy, faculty for this meeting are is accredited by the Accreditation Council for Continuing expected to disclose any economic or other personal interests Medical Education (ACCME) to provide continuing medical that create, or may be perceived as creating, a confl ict related education for physicians. to the material discussed. All confl icts of interest must be resolved prior to the annual meeting. In addition, consistent Continuing Medical Education Credits with ASTMH policy, faculty are expected to disclose to The American Society of Tropical Medicine and Hygiene attendees at the beginning of their presentation(s) any product designates this educational activity for a maximum of 33.5 mentioned during their presentation that is not labeled for the AMA PRA Category 1 Credit(s)™. Physicians should claim only use under discussion or is still investigational. This policy is credit commensurate with the extent of their participation in intended to allow you to form your own judgments about such the activity. material.

Register for CME Credit The CME documentation fee is $125. CME certifi cates will be mailed in mid-January. Complete your CME evaluation form online. Visit the ASTMH Cyber Café and complete your online CME Attendance and Evaluation Form while at the meeting or access the evaluation form at www.astmh.org/ source/cme.

27 www.astmh.org ASTMH 58th Annual Meeting

General Meeting Information Hotel Information The Marriott Wardman Park is the site of all annual meeting Pre-Meeting Course Registration Hours activities. Salon Foyer Registration Desk (First Floor) Marriott Wardman Park Tuesday, November 17 ...... 7 a.m. – 1:30 p.m. 2660 Woodley Road, N.W. Washington, DC 20008 Annual Meeting Registration Hours Phone +1-202-328-2000 Salon Foyer Registration Desk (First Floor) Fax: +1-202-234-0015 Wednesday, November 18...... 9:30 a.m. – 6 p.m. Thursday, November 19 ...... 7 a.m. – 5 p.m. Hotel Parking Friday, November 20 ...... 7 a.m. – 5 p.m. Parking at the Marriott is currently $17 per hour or $32 (tax Saturday, November 21 ...... 7 a.m. – 5 p.m. inclusive) per day. Valet parking service is available for $37 Sunday, November 22 ...... 7 a.m. – 10:30 a.m. (tax inclusive).

Messages and Emergency Calls Americans with Disabilities Act A message board will be available near the ASTMH registra- ASTMH fully complies with the legal requirements of the tion desk. Check the message board often to retrieve your ADA and the rules and regulations thereof. messages. Phone calls should be directed to +1-202-328-2000, the main switchboard of the Marriott Wardman Park. Callers Exhibits should ask to be connected to the ASTMH registration desk. Exhibit Hall A, Exhibition Level Faxes can be sent to the hotel at +1-202-234-0015. The ASTMH 58th Annual Meeting features an exposition of displays by leading suppliers and vendors. A complete Badges/Access Control exhibitor and supporter directory is included on page 37. Participation in the ASTMH Annual Meeting is limited to registered attendees. Exhibit Hours Wednesday, November 18...... 7:30 p.m. – 9:30 p.m. An offi cial badge is required for admission to all sessions, Thursday, November 19 ...... 9:30 a.m. – 10:30 a.m. social activities and exhibit area. Do not place a business card Noon – 1:30 p.m. into your badge holder as identifi cation. If there is an error on 3 p.m. – 4 p.m. a badge, please have it corrected at the ASTMH registration Friday, November 20 ...... 9:30 a.m. – 10:30 a.m. desk. Noon – 1:30 p.m. 3 p.m. – 4 p.m. Replacement Badge Saturday, November 21 ...... 9:30 a.m. – 10:30 a.m. If your badge is lost, you must purchase a replacement badge Noon – 1:30 p.m. for a fee of $15. Bring your photo I.D. with you to the regis- tration desk to have a new badge issued. This fee will not be Solicitations refunded if you fi nd your original badge. Sales and promotional activities are restricted to exhibitors and must take place in their assigned exhibit area. Solicitations by Spouse/Guest Registration unauthorized persons are strictly prohibited. (Only for those outside the tropical medicine fi eld) Spouse/guest registration includes admission to the opening Cyber Café reception on Wednesday and admission to the exhibit hall, Visit the Cyber Café in the Marriott Foyer on the mezzanine plenary sessions and poster sessions only. level on the second fl oor. As a courtesy to other attendees, please limit your computer use to 10 minutes per visit. Food Functions The following food functions are included in the registration Media Room fee: The media room (for professional journalists reporting on the • Opening reception (Wednesday) conference) is located in rooms 8228 and 8229 on the fi rst • Late Breakers in Clinical Tropical Medicine and Basic fl oor. ASTMH media kits are available. Media announce- Science/Molecular Biology light lunch (Thursday ments and other details can be found here. Media room hours afternoon and Friday afternoon mid-day sessions) of operation are: • Poster session lunches (Thursday, Friday and Saturday) Wednesday, November 18...... 8 a.m. – 4 p.m. • Coffee breaks Thursday, November 19 ...... 7:30 a.m. – 6:30 p.m. Friday, November 20 ...... 7:30 a.m. – 6:30 p.m. Saturday, November 21 ...... 7:30 a.m. – 6 p.m. Sunday, November 22 ...... 7:30 a.m. – 1 p.m.

28 ASTMH 58th Annual Meeting www.astmh.org

Employment Opportunities Disclaimer Bulletin boards for posting employment opportunities are ASTMH is not responsible for the opinions expressed by available in the ASTMH registration area. speakers or the content of speaker handout materials.

Career Center Meeting Evaluation Our online Career Center, available at www.astmh.org, ASTMH needs your input to enhance future meetings. An on- features a wide range of available positions in the tropical line meeting evaluation survey will be e-mailed to you shortly medicine and hygiene fi eld. Members can post resumes anony- after the meeting. Your participation in this survey is greatly mously and search for jobs by keyword, location and job type. appreciated. The scientifi c program committee welcomes your Employers can set up an account, post open positions on the input concerning the format and planning of this and future ASTMH Web site and search the ASTMH resume bank for ASTMH meetings. Organization of symposia and participation qualifi ed applicants. in educational program planning through the program commit- tee is encouraged for all interested ASTMH members. Camera/Recording Restrictions Only registered members of the media and attendees who re- ceive prior approval from ASTMH staff may take cameras into the exhibit hall or use recording devices during sessions.

Meeting Room Directory The American Journal of Tropical Medicine and Hygiene Exhibition Floor/ Second Floor/ Lower Level Mezzanine Level Trial Journal Subscriptions Exhibit Hall A Balcony A The American Journal of Tropical Medicine and Hygiene has (Exhibit Hall) Balcony B included a complimentary trial subscription number in your Exhibit Hall B South Balcony C registration packet. Non-members can activate this 90-day (Poster Hall) Balcony D trial to enjoy the benefi ts of an online journal subscription at Washington 1 Buchanan no charge. Members already enjoy a subscription to the online Washington 2 Cleveland 1 journal and can pass the trial subscription number along to a Washington 3 Cleveland 2 non-member colleague. Washington 4 Coolidge Washington 5 Hoover Washington 6 Jackson Mid-Day Session 79 Jefferson First Floor/Lobby Level Johnson ASTMH Journal Symposium Capitol Boardroom Marriott Foyer (Cyber Café) Preparation and Review of Scientifi c Manuscripts for the Delaware A Taft American Journal of Tropical Medicine & Hygiene Delaware B Taylor Friday, November 20 Maryland A Truman (Speaker Ready Room) Tyler 12:15 p.m. - 1:15 p.m. Salon 1 Wilson A Delaware B Salon 2 Wilson B This symposium is aimed at trainees and others interested in Salon 3 Wilson C understanding better how manuscripts are reviewed, edited Salon Foyer (Registration) and processed by the society’s journal. Pointers on preparation Virginia AB Wardman Tower Building and review of manuscripts will be stressed. The following Virginia C Lobby Level/First Floor topics will be covered: 1) Why publish your work in our Room 8210 Embassy society’s journal; 2) Why and where to publish, i.e. selection Room 8211 Ethan Allen of the “right” journal for your work; 3) Examples of a paper Room 8212 Nathan Hale in progress; how to prepare and how to write a good paper; Room 8216 Thomas Paine 4) The submission and review processes and how they work; Room 8217 5) How to properly review a paper; 6) How to respond to Room 8218 reviewer comments; and 6) The publication process: what (Meeting Room Sign-Up) happens after your paper is accepted. Room 8219 (Meeting Room Sign-Up) Room 8222 Room 8223 Room 8228 (Press Room) Room 8229 (Press Room) 29 www.astmh.org ASTMH 58th Annual Meeting

Program Information American Committee on Arthropod-Borne Viruses (ACAV) Slide Presentation: History of Annual Meeting Audio Recordings Arbovirology and Hemorrhagic Fever Virology Can’t fi gure out how to be in two places at once? Problem solved! With so much cutting-edge science available at the We invite you to view the ACAV slide display, located in the ASTMH conference, you can purchase audio recordings of exhibit hall. Slides will feature information about the group’s sessions you missed. Visit the sales desk in the registration founding in 1959 and profi le members’ contributions to the area to purchase a CD and/or multimedia CD-ROM of the fi eld. The presentation also reviews the history of arbovirol- conference sessions from IntelliQuest Media. Discounts will ogy and hemorrhagic fever virology. Help ACAV celebrate be extended for onsite orders. Contact IntelliQuest Media at its 50th anniversary and take a moment to view this special +1-866-651-2586 or visit www.intelliquestmedia.com. presentation. Late Breaker Abstracts Late Breakers in Clinical Tropical Medicine Elsevier Student Book Award Applicants Late Breaker Abstract Session 25 Late Breaker Abstract Session 78 This award recognizes excellence in clinically oriented Thursday, November 19 and Friday, November 20 research presented by students (within six months of complet- 12:15 p.m. – 1:15 p.m. ing undergraduate or master’s level training, including medical Delaware A undergraduate degrees) or those in graduate medical train- ing, of work submitted and presented (oral or poster) at the Late Breakers in Basic Science/Molecular Biology ASTMH Annual Meeting. Support these young scientists by Late Breaker Abstract Session 26 attending their presentations throughout the conference. Late Breaker Abstract Session 80 Thursday, November 19 and Friday, November 20 Corine Demanga 12:15 p.m. – 1:15 p.m. Abstract 560 Virginia AB A novel approach to design multicomponent blood stage malaria vac- cines These sessions are designed for brief presentations of im- portant new data obtained after the closing date for abstract Michael Hawkes submission. Oral late breaker presentations will take place on Abstract 985 Thursday afternoon and Friday afternoon during the mid-day CD36 defi ciency and resistance to mycobacterial infection session period. Poster late breaker presentations will take place during the poster sessions on Thursday, Friday and Saturday. Deepthi Kattula A schedule of late breaker abstract presentations can be found Abstract 459 in your registration packet. Effi cacy of mass drug administration (MDA) of albendazole in the reduction of soil transmitted helminth infection in south India: Meet the Professors Comparison of data from two adjacent districts of Tamil Nadu Meet the Professors sessions are small, interactive programs held on Thursday, Friday and Saturday during the mid-day An Na Park session period. The sessions are open to all meeting partici- Abstract 770 pants and a light meal will be provided. While the professors Immigrant screening in the inpatient setting in a municipal hospital will lead the program and have some prepared remarks, the sessions will be largely question-and-answer format. Voravuth Somsak Abstract 209 ACMCIP Abstracts Transgenic model for anti-P. vivax Dihydrofolate reductase-thymidy- Throughout this book, you will notice that some abstracts are late synthase screening followed by the notation “(ACMCIP abstract).” This notation means the abstract submitter indicated that the abstract per- Barclay Stewart tains to molecular, cellular or immunoparasitology. ACMCIP Abstract 371 refers to the American Committee of Molecular, Cellular and Prevalence and correlates of helminth co-infection in HIV-1 infected Immunoparasitology, an ASTMH subgroup. For more infor- Kenyan adults mation, go to http://www.astmh.org/ACMCIP.htm. Huong Vu Late Breaker Abstract 2486 The role of nasopharyngeal load of Streptococcus pneumonia and its interaction with viral co-infection in the development of childhood pneumonia in Vietnam

30 ASTMH 58th Annual Meeting www.astmh.org

Special Events for Trainees, Meet the Professors 81* Students, Fellows, Residents Meet the Professors B: Enigmatic and Teaching Cases and Junior Faculty Friday, November 20, 12:15 p.m. - 1:15 p.m. Virginia C

Events featuring light meals denoted with an asterisk (*). Symposium 119 Transitioning to Senior Investigator: Experiences from Young Investigator Award Presentations Developing Countries Wednesday, November 18, 11 a.m. – 3:30 p.m. Saturday, November 21, 8 a.m. - 9:45 a.m. Jackson, Jefferson, Johnson, Taylor, Truman Wilson A

Student Reception* Symposium 126 Wednesday, November 18, 4 p.m. – 5 p.m. Crossing Boundaries: Models of North-South and Exhibit Hall B South Interprofessional Education Saturday, November 21, 10:15 a.m. -Noon The ASTMH council invites students, postdoctoral fellows and Virginia C residents to the student reception. This reception is an oppor- tunity to meet fellow trainees and interact with society leaders. Mid-Day 133A Symposium 11 Workshop on Manuscript Preparation: How to Get Your Work Published NIH and Tropical Medicine: Supporting International Saturday, November 21, 12:15 p.m. - 1:15 p.m. Research and Career Development - Part I Delaware A Thursday, November 19, 8 a.m. - 9:45 a.m. Washington 5 Meet the Professors 135* Symposium 22 Meet the Professors C: Enigmatic and Teaching Cases Saturday, November 21, 12:15 p.m. - 1:15 p.m. NIH and Tropical Medicine: Supporting International Virginia C Research and Career Development - Part 2 Thursday, November 19, 10:15 a.m. – Noon Washington 5

Meet the Professors 27* Meet the Professors A: Enigmatic and Teaching Cases Thursday, November 19, 12:15 p.m. - 1:15 p.m. Virginia C

Mid-Day Session 28 Welcome Trust Seminar: Successful Research, Grant Writing, Mentorship and Career Advice Thursday, November 19, 12:15 p.m. - 1:15 p.m. Washington 5

Symposium 55 Launching Careers in Tropical Disease Research: Progress Reports from Burroughs Wellcome Fund/ASTMH and Fellows Friday, November 20, 8 a.m. - 9:45 a.m. Salon 3

Mid-Day Session 79 Preparation and Review of Scientifi c Manuscripts for the American Journal of Tropical Medicine & Hygiene Friday, November 20, 12:15 p.m. - 1:15 p.m. Delaware B

31 www.astmh.org Clinical Session Guide

Clinical Pre-Meeting Course Meet the Professors 81 The Highly Prevalent Neglected Tropical Diseases (NTDs): Meet the Professors B: Enigmatic and Teaching Cases Update on Clinical Aspects and Novel Approaches to Friday, November 20, 12:15 p.m. - 1:15 p.m. Control Virginia C Tuesday, November 17, 1 p.m. - 5:30 pm Wednesday, November 18, 7:30 a.m. – 3 p.m. Symposium 83 Salon 1 Clinical Group I Friday, November 20, 1:30 p.m. - 3:15 p.m. Symposium 4 Salon 2 The Evolution of Q Fever: Updates on Recent Changes in Epidemiology, Diagnosis, Clinical Manifestations, Symposium 95 Treatment and Follow-Up Clinical Group II Thursday, November 19, 8 a.m. - 9:45 a.m. Friday, November 20, 3:45 p.m. - 5:30 p.m. Delaware B Salon 2

Symposium 14 Symposium 117 New Drugs against Human African Trypanosomiasis and Global Health and Mass Travel Events Visceral Leishmaniasis - Activities of the Consortium for Saturday, November 21, 8 a.m. - 9:45 a.m. Parasitic Drug Development Washington 4 Thursday, November 19, 10:15 am - Noon Delaware A Symposium 130 Communicable Diseases in Post-Confl ict Settings Late Breaker Session 25 Saturday, November 21, 10:15 am - Noon Late Breakers in Clinical Tropical Medicine Washington 4 Thursday, November 19, 12:15 p.m. - 1:15 p.m. Delaware A Meet the Professors 135 Meet the Professors C: Enigmatic and Teaching Cases Meet the Professors 27 Saturday, November 21, 12:15 p.m. - 1:15 p.m. Meet the Professors A: Enigmatic and Teaching Cases Virginia C Thursday, November 19, 12:15 p.m. - 1:15 p.m. Virginia C Symposium 142 Managing Childhood Illness at Community Level: Good Scientifi c Session 36 News from Africa Clinical Tropical Medicine I Saturday, November 21, 1:30 pm - 3:15 pm Thursday, November 19, 1:30 p.m. - 3:15 p.m. Virginia C Washington 1 Symposium 155 Scientifi c Session 47 International Programmatic Experience in Lymphedema Clinical Tropical Medicine II Management for Lymphatic Filariasis Thursday, November 19, 3:45 p.m. - 5:30 p.m. Saturday, November 21, 3:45 pm - 5:30 pm Washington 1 Virginia C

Symposium 63 Symposium 163 Update on Chagas Disease in the United States: Blood Clinical Update: What’s New in Literature Bank Screening and Diagnostic Options Sunday, November 22, 8 a.m. - 9:45 am Friday, November 20, 8 a.m. - 9:45 a.m. Salon 2 Washington 4 Scientifi c Session 175 Symposium 70A Clinical Tropical Medicine III Improving the Health of Travelers and New Immigrants Sunday, November 22, 10:15 a.m. - Noon and Refugees: Evidence-Based Approaches Salon 2 Friday, November 20, 10:15 a.m. - Noon Virginia AB

Late Breaker Session 78 Late Breakers in Clinical Tropical Medicine Friday, November 20, 12:15 p.m. - 1:15 p.m. Delaware A

32 ASTMH 58th Annual Meeting www.astmh.org

Poster Sessions Speaker Ready Room and Audiovisual Guidelines

Exhibit Hall B South, Lower Level Maryland A, First Floor Three poster sessions will be held at the ASTMH 58th Annual Meeting in Exhibit Hall B South on the exhibition level. There Hours are additional times for poster viewing (presenters need not be in Wednesday, November 18...... Noon – 6 p.m. attendance during these time periods). We encourage attendees Thursday, November 19 ...... 7 a.m. – 6 p.m. to visit the poster hall throughout the day. Poster viewing time is Friday, November 20 ...... 7 a.m. – 6 p.m. scheduled each day in the morning and afternoon. Saturday, November 21 ...... 7 a.m. – 6 p.m. Sunday, November 22 ...... 7 a.m. – Noon Poster Session Schedule Load your presentation in the Speaker Ready Room 24 hours Poster Session A prior to your session. If you are unable to do so and you are Thursday, November 19 speaking that day, please visit the Speaker Ready Room as early as possible on the morning of your talk. Set-Up ...... 9:45 a.m. – 10:15 a.m. Presentations ...... Noon – 1:30 p.m. Presentation Format. All meeting rooms will be equipped Viewing ...... 10:15 a.m. – Noon with one Windows XP computer with CD/DVD drive 1:30 p.m. – 7 p.m. Dismantle ...... 7 p.m. – 8 p.m. and PowerPoint 2007 software, screen, LCD projector display device, microphone and laser pointer. You will not Poster Session B be permitted to connect your own computer to the LCD Friday, November 20 projector. Your presentation will be run from the AV technician’s PC-based computer. Set-Up ...... 9:45 a.m. – 10:15 a.m. Presentations ...... Noon – 1:30 p.m. Bring only your presentation on CD/DVD or memory stick Viewing ...... 10:15 a.m. – Noon and bring a backup copy. Your CD/DVD must be in a format 1:30 p.m. – 7 p.m. that is compatible with the equipment listed above. Dismantle ...... 7 p.m. – 8 p.m.

Poster Session C Saving Your Presentation File. Save your presentation as Saturday, November 21 MS PowerPoint slides in a format that is compatible with PowerPoint 2007 on Windows XP or as an Adobe PDF Set-Up ...... 9:45 a.m. – 10:15 a.m. fi le. Macintosh and PC versions of PowerPoint, Canvas and Presentations ...... Noon – 1:30 p.m. Keynote allow you to save presentations in a variety of formats Viewing ...... 10:15 a.m. – Noon that meet these specifi cations. 1:30 p.m. – 7 p.m. Dismantle ...... 7 p.m. – 8 p.m. If your presentation includes linked fi les, such as databases or spreadsheets, be sure to save those on the CD, as well. Online Program Test your presentation on a Windows machine running Windows XP to ensure your presentation runs properly. Following the meeting, search the annual meeting program online by abstract word, title, subject, author and presentation For Macintosh PowerPoint users, please insert pictures using time at http://www.astmh.org. Late breaker abstracts can be ‘insert’ - ‘picture’ - ‘from fi le’, rather than copying and pasting, found in the Online Program Planner. to ensure they will display properly on a Windows PC.

Embedded Videos. If your presentation includes video, it is imperative that you visit the Speaker Ready Room in advance of your presentation to ensure compatibility with meeting equipment.

It is best to use a “wmv,” “avi,” or “mpg” format for embedded video, not QuickTime “mov.” Please be sure NOT to use Sorenson compression on avi’s from Mac computers.

You must upload your video fi les, as well as your PowerPoint fi le, for the videos to play.

We strongly encourage you to load your presentation in the Speaker Ready Room 24 hours prior to presentation time.

33 www.astmh.org ASTMH Travel Awards, Fellowships & Grants

ASTMH Travel Awards Meera Venkatesan Johns Hopkins School of Public Health, Baltimore, Maryland, USA Supported with funding from the Bill & Melinda Gates Foundation Shuyi Zhang University of California at San Francisco, San Francisco, California, USA James LeDuc, Chair University of Texas Medical Branch, Galveston, Texas, USA Runners-Up Pamela Orjuela-Sánchez The ASTMH travel awards program supports travel to the University of São Paulo, São Paulo, Brazil annual meeting by selected students and young investigators from developing countries and the United States. James Potts Massachusetts General Hospital, Boston, Massachusetts, USA See page 26 for a list of 2009 travel award recipients. Jennifer Simpson American Committee of Medical Entomology Yale University, New Haven, Connecticut, USA (ACME) Travel Awards Kristin Smith University of Florida, St. Augustine, Florida, USA Edward Walker, Chair Michigan State University, East Lansing, Michigan, USA Prakash Srinivasan National Institutes of Health/National Institute of Allergy and Infec- The ACME travel awards program supports travel to the tious Diseases, Bethesda, Maryland, USA ASTMH annual meeting by graduate students whose work involves arthropods of medical importance. Honorable Mentions Charles Criscione Lauren Cator Texas A&M University, College Station, Texas, USA Cornell University, Ithaca, New York, USA Julio Croda Win Surachetpong Oswaldo Cruz Foundation, Salvador, Brazil University of California at Davis, Davis, California, USA David Larson Young Investigator Awards Uniformed Services University of the Health Sciences, Bethesda, Mary- land, USA In Honor of William A. Petri, Sr. In Memory of Annie Liberati Edwin Ochong Supported with funding from TechLab, Inc. Liverpool School of Tropical Medicine, Liverpool, United Kingdom

Peter Zimmerman, Chair Nikos Vasilakis Case Western Reserve University, Cleveland, OH, USA University of Texas Medical Branch, Galveston, Texas, USA Young Investigator Awards are given to young scientists who have completed the majority of work described in their Burroughs Wellcome Fund-ASTMH Postdoctoral accepted abstracts as undergraduates, graduate students or Fellowship in Tropical Infectious Diseases during the fi rst two years of postdoctoral research. The young investigators hold a primary role in the reported experimental Supported with funding from the Burroughs Wellcome Fund work, as evidenced by fi rst-author status on their abstracts. Terrie Taylor, Chair 2008 Recipients (selected during ASTMH 57th Michigan State University, East Lansing, Michigan, USA Annual Meeting in December 2008) Jacqueline Janka This fellowship encourages long-term career development in National Institutes of Health/National Institute of Allergy and Infec- tropical infectious diseases by providing support to individuals tious Diseases, Bethesda, Maryland, USA who will pursue careers focused on clinical research in tropical or developing areas of the world. Agnes Mwakingwe Albert Einstein College of Medicine, Bronx, New York, USA

Samantha McNulty Washington University, St. Louis, Missouri, USA

34 ASTMH Travel Awards, Fellowships & Grants www.astmh.org

2008 Recipients Rodwell Mabaera Nina Lin Dartmouth Medical School, Hanover, New Hampshire, USA Massachusetts General Hospital, Boston, Massachusetts, USA “Characterization of HIV-1 subtype C infection in Botswana: Tracy Mak Viral tropism and genetic diversity in transmission” Weill Cornell Medical College, New York, New York, USA

Scott Peterson Marilyn Michelow Harvard Medical School, Boston, Massachusetts, USA Weill Cornell Medical College, New York, New York, USA “Who can safely formula-feed in Botswana? A prospective observational cohort study to assess counseling of HIV- Grace Milad infected women around infant feeding choices, and predictors University of Virginia School of Medicine, Charlottesville, Virginia, of mortality among their formula-fed infants” USA

Joseph Tucker Molly Paras Massachusetts General Hospital, Boston, Massachusetts, USA Mayo Clinic College of Medicine, Rochester, Minnesota, USA “Optimizing integrated syphilis and HIV testing in south Chi- nese STI clinics” Barclay Stewart Medical University of South Carolina, Beaufort, South Carolina, USA Benjamin H. Kean Traveling Fellowship in Tropical Medicine Scott Tolan University of Texas School of Medicine at Houston, Houston, Texas Christopher Plowe, Chair Aaron Tustin University of Maryland, Baltimore, MD, USA Vanderbilt University School of Medicine, Nashville, Tennessee, USA This fellowship is designed to provide travel support to medi- Richard Waters cal students who arrange clinical tropical medicine or tropical Duke University School of Medicine, Durham, North Carolina, USA medicine research electives overseas. April Wilhelm Sara Janne Aarsland Brown University Warren Alpert Medical School, Providence, Rhode The University of Texas Medical Branch, Galveston, Texas, USA Island, USA Byron Berenger University of Calgary, Calgary, Alberta, Canada Gorgas Memorial Institute Research Award

Rachel Bystritsky Kathryn Aultman, Chair Mount Sinai School of Medicine, New York, New York, USA Bill & Melinda Gates Foundation, Seattle, Washington

Youngjee Choi This award supports short-term travel for young research- Washington University School of Medicine, St. Louis, Missouri, USA ers from Panama, Central America, tropical and sub-tropical South America and the Caribbean Islands, and Mexico in L. Emily Cotter order to facilitate scientifi c linkages between these regions George Washington University, Washington, DC, USA and the United States and Canada. The award is also meant to foster collaborative biomedical research focused on tropi- Dylan Davey cal diseases affl icting residents of Latin America and to enable Yale University, New Haven, Connecticut, USA researchers to learn new techniques and approaches applicable to the study of such diseases. Qyana Griffi th Boston University School of Medicine, Boston, Massachusetts, USA The 2009 recipient will be announced in December.

Jenny Hsu University of Vermont College of Medicine, Burlington, Vermont, USA

Alexis Kearney Mount Sinai School of Medicine, New York, New York, USA

Kristina Krohn University of Minnesota, Minneapolis, Minnesota, USA

35 www.astmh.org ASTMH 58th Annual Meeting

Pfi zer Centennial Travel Award in Basic Science Robert E. Shope International Fellowship in Tropical Disease Research Infectious Diseases

Joseph Vinetz, Chair Charles Calisher, Chair University of California San Diego, San Diego, California, USA Colorado State University, Fort Collins, Colorado, USA

This award provides support to individuals with doctoral-level This fellowship provides support for travel, living expenses, degrees who travel to laboratories in the tropics to perform and research for doctoral-level scientists working in molecular, cellular or immunological studies of tropical infec- laboratories overseas on studies pertaining to arbovirology tious diseases. and/or emerging tropical infectious diseases.

Robert Comer Andrew Haddow Wake Forest University Baptist Medical Center, Winston-Salem, University of Texas Medical Branch, Galveston, Texas, USA North Carolina, USA “The ecology of sylvatic arboviruses in eastern Senegal”

Sansanee Noisakran Emory University, Atlanta, Georgia, USA “Linkage of platelets and adaptive immunity in dengue virus infection”

MARK YOUR CALENDAR! ATLANTA, GA ASTMH 59th ASTMH 60th ASTMH 61st Annual Meeting Annual Meeting Annual Meeting November 3–7, 2010 December 4–8, 2011 November 11–15, 2012 Atlanta Marriott Marquis Philadelphia Marriott Atlanta Marriott Marquis Atlanta, Georgia USA Downtown Atlanta, Georgia USA Philadelphia, Pennsylvania USA

PHILADELPHIA, PA

www.astmh.org 36 Exhibitor and Supporter Directory www.astmh.org

American Society for Microbiology (ASM Press)

Contact: Alaina Scalercio 1752 N St., NW Washington, DC 20036-2904 USA Phone: +1-800-546-2416 Fax: +1-202-942-9342 E-mail: [email protected] Booth 204 ASM Press, the book publishing division of the American Society for Microbiology, will be exhibiting a selection of texts, references and general interest titles at the meeting. Be sure to stop by the ASM Press booth to see all the new offerings and classic titles in the microbiological sciences. ASM Press offers a 10% discount on all purchases made at the meeting.

Armed Forces Health Surveillance Center (AFHSC)

Contact: Jennifer Bondarenko 2900 Linden Lane Suite 100 Silver Spring, MD 20970 USA Phone: +1-301-319-9072 Fax: +1-301-319-9213 E-mail: [email protected] Booth 600 and 602 The AFHSC’s main functions are to analyze, interpret and disseminate information regarding the status, trends and determinants of the health and fi tness of U.S. military (and military-associated) populations, and to identify and evaluate obstacles to medical readiness. AFHSC is the central epidemiological resource for the U.S. Armed Forces to provide regularly scheduled and customer-requested analyses and reports to policy makers, medical planners and researchers. It identifi es and evaluates obstacles to medical readiness by linking various databases that contain information relevant to service members’ health. This mission is accomplished by the following three divisions: Data and Analysis Division, Africa Health Placements, South Africa Global Emerging Infections Surveillance and Response System (GEIS) Operations Division and Communications, Standards Contact: Therese Hansen and Training (CST) Division. Dunkeld West Centre Suite 265 Johannesburg, South Africa 2196 Phone: +1-206-465-8824 USA +27 011 3281300 (South Africa) Fax: +27 11 328 1301 (South Africa) E-mail: [email protected] Booth 406 Africa Health Placements (AHP) is a South African non-profi t organization recruiting doctors to work in South Africa’s rural hospitals. Broad-based clinical practice focuses on maternal and child health, infectious diseases and emergency care. AHP will assist you in fi nding a suitable position and provide you with highly-skilled registration/visa/logistical support.

37 www.astmh.org Exhibitor and Supporter Directory

Bill & Melinda Gates Foundation Carramore International Ltd

P.O. Box 23350 Contact: Alasdair Grant Seattle, WA 98102 Units 10-11 Phone: +1-206-709-3100 Thongsbridge Mills E-mail: [email protected] Miry Lane Guided by the belief that every life has equal value, the Bill Holmfi rth HD9 7RW & Melinda Gates Foundation works to help all people lead United Kingdom healthy, productive lives. In developing countries, it focuses Phone: +44 1484 690 444 on improving people’s health and giving them the chance to lift Fax: +44 1484 690 456 themselves out of hunger and extreme poverty. In the United E-mail: [email protected] States, it seeks to ensure that all people – especially those Booth 103 with the fewest resources – have access to the opportunities they need to succeed in school and life. Based in Seattle, the Carramore — a single source for your supplies and shipping foundation is led by CEO Jeff Raikes and co-chair William H. diagnostic specimens Gates, Sr., under the direction of Bill and Melinda Gates and Carramore is an independent buying house specializing in Warren Buffett. www.gatesfoundation.org supplying research laboratories based in the tropics. We can source from all over the world to meet all your particular requirements, and we will check and monitor all aspects of the Burroughs Wellcome Fund/The Wellcome Trust logistics to ensure that you receive the products and specimens in your laboratory quickly and safely. Contact: Jean A. Kramarik Carramore …making life easy 21 T.W. Alexander Drive Research Triangle Park, NC 27709-3901 USA Phone: +1-919-991-5122 Cooperative Pathology Laboratory, Fax: +1-919-991-5182 University of Georgia E-mail: [email protected] Contact: Tamas Nagy Booth 502 Department of Pathology, College of Vetinerary Medicine The Burroughs Wellcome Fund is an independent private 501 DW Brooks Drive foundation dedicated to advancing the biomedical sciences Athens, GA 30602-7388 USA by supporting research and other scientifi c and educational Phone: +1-706-202-8608 activities. The Wellcome Trust is an independent charity Fax: +1-706-542-5828 funding research to improve human and animal health. E-mail: [email protected] Booth 313 Caister Academic Press Laboratory Animal Pathology Services: (1) Autopsy Contact: Annette Griffi n (Necropsy) of Research Animals, (2) Histopathology, (3) Rowan House Immunohistochemistry, (4) Phenotyping of Genetically 28 Queens Road, Hethersett Engineered Mice, (5) Biochemedical Imaging, (6) Clinical Norwich, Norfolk NR9 3DB Pathology (Hematology, Cytology, Bone Marrow Evaluation, United Kingdom etc.), (7) Infectious Disease Surveillance, (8) Serology, Phone: +44-1953-603068 Bacteriology, Parasitology, and Molecular Biology for Fax: +44-1953-606952 Laboratory Animals, (9) Research Collaboration and E-mail: www.horizonpress.com Consultation, (10) Assistance with Grant Applications. Take One Table Drugs for Neglected Diseases initiative (DNDi) Caister Academic Press is an imprint of Horizon Scientifi c Press, a small, independent publisher specializing in publishing Contact: Violaine Dällenbach books in the areas of microbiology, molecular biology and 15 Chermin Louis-Donant genomics. Geneva 1202 Switzerland Phone: +41-22-906-93-47 Fax: +41-22-906-93-31 E-mail: [email protected] Booth 503 The Drugs for Neglected Diseases initiative (DNDi) is an independent, not-for-profi t product development partnership working to research and develop new and improved treatments

38 Exhibitor and Supporter Directory www.astmh.org for neglected diseases such as leishmaniasis, human African ICF Macro trypanosomiasis, Chagas disease and malaria. DNDi was founded in 2003 by four publicly-funded research institutes Contact: Erin Eckert from Malaysia, India, Kenya and Brazil, along with the Institut 11785 Beltsville Dr. Pasteur and Médecins Sans Frontières (MSF). The UNICEF/ Suite 300 UNDP/World Bank/WHO Special Programme for Research Calverton, MD 20705 USA and Training in Tropical Diseases (TDR) acts as a permanent Phone: +1-301-572-0255 observer. Fax: +1-301-572-0898 E-mail: [email protected] Elsevier/Saunders Booth 107 ICF Macro, an ICF International company, is dedicated to Contact: Brian Karafi n improving lives worldwide through social research and health 15807 Quince Orchard Rd. informatics. We work with governments, businesses and N. Potomac, MD 20878 USA international organizations to assess emerging public health Phone: +1-240-477-8564 challenges, improve interventions and expand the impact of Fax: +1-240-477-8571 successful programs. E-mail: b.karafi [email protected] Booth 207 International Association for Medical Assistance Stop by and see Manson’s - Tropical Diseases, Mandell’s to Travelers (IAMAT) – Infectious Diseases, Keystone’s – Travel Medicine, CDC – Health Information Guide, Infectious Disease Clinics of North 2162 Gordon Street America and many more titles of interest. Guelph, ON N1L 1G6 Canada Phone: +1-519-836-0102 GlaxoSmithKline Fax: +1-519-836-3412 E-mail: [email protected] Contact: Suzanne M. Kelly IAMAT is a non-profi t organization dedicated to travel health. 3 Franklin Plaza 3FO525 As an advocate for travelers’ health, IAMAT has provided Philadelphia, PA 19102 USA independent and accurate travel health advice since 1960. The Phone: +1-215-751-4000 organization also coordinates a network of highly qualifi ed Fax: +1-215-751-5050 doctors worldwide for travelers in need of medical attention E-mail: www.gsk.com during their journey. Since 2002, IAMAT has awarded Booth 209 scholarships and grants to doctors and nurses from developing countries to study and train in the fi eld of travel medicine. GlaxoSmithKline is a leading research-based pharmaceutical IAMAT was founded by the late Dr. Vincenzo Marcolongo, company with a powerful combination of skills to discover and a specialist in tropical medicine who dedicated his life to the deliver innovative medicines. We offer a number of programs to support effective health management strategies and improve prevention of infectious diseases in travelers. patient care. Please visit our exhibit to learn more about our products.

39 www.astmh.org Exhibitor and Supporter Directory

IVCC (Innovative Vector Control Consortium) Mary Ann Liebert, Inc., Publishers

Contact: Tom McLean Contact: Lisa Pierce IVCC, c/o Liverpool School of Tropical Medicine 140 Huquenot St. Pembroke Place New Rochelle, NY 10801 USA Liverpool, Merseyside L35QA Phone: +1-914-740-2100 United Kingdom Fax: +1-914-740-2101 Phone: +0151-705-3202 E-mail: [email protected] Fax: +0151-705-3345 Take One Table E-mail: [email protected] Mary Ann Liebert, Inc. (www.liebertpub.com) is a privately Booth 512 and 413 held, fully integrated media company known for establishing The IVCC is a Product Development Partnership established to authoritative peer-reviewed journals in new and promising areas overcome the barriers to innovation in the development of new of science and biomedical research. Vector-Borne and Zoonotic insecticides for public health vector control and to develop information Diseases (www.liebertpub.com/vbz), the offi cial Journal of systems and tools which will enable new and existing pesticides to be SocZEE - Society for Zoonotic Ecology and Epidemiology, used more effectively. Our strategy is to support those projects by the provides a unique platform for basic and applied disease research. development of partnerships that bring together the complete set of A complete list of the fi rm’s 60 journals, newsmagazines, and resources to bring those products to market. books is available at (www.liebertpub.com). Complimentary copies of the Journal are available at the Take One Tables. International Society for Infectious Diseases National Institute of Allergy and Contact: Eric Summers Infectious Diseases 1330 Beacon Street Suite 228 Contact: Hillary E. Turner Brookline, MA 02446 USA 6610 Rockledge Dr., MSC 6612 Phone: +1-617-277-0551 Bethesda, MD 20892-6612 USA Fax: +1-617-278-9113 Phone: +1-866-284-4107 E-mail: [email protected] Fax: +1-301-402-3573 Take One Table E-mail: www.niaid.nih.gov The ISID is an educational non-profi t organization with over 30,000 Booth 206 members worldwide. Its objectives are to promote communication The National Institute of Allergy and Infectious Diseases among those engaged in all aspects of infectious diseases. These goals conducts and supports basic and applied research to are achieved through international scientifi c meetings, exchange better understand, treat and ultimately prevent infectious, fellowships, grants for infection control programs, a newsletter and the immunologic and allergic diseases. NIAID staff will distribute International Journal of Infectious Diseases. printed information and answer questions on these subjects. Representatives from the Employment Outreach Team will be Malaria Research and Reference Reagent present to discuss career opportunities at NIAID. Resource Center (MR4)

Contact: Timothy Stedman and Julie Dogil 10801 University Blvd Manassas, VA 20110 USA Phone: +1-703-365-2765 Fax: +1-703-365-2774 E-mail: [email protected] Booth 301 The Malaria Research and Reference Reagent Resource Center (MR4) provides a central resource for reagents, protocols, information and workshops to the international malaria research community. Supported by the National Institute of Allergy and Infectious Diseases (NIAID), the MR4 repository acquires, preserves, authenticates and distributes parasites, mosquito vectors, and associated biological and molecular reagents for nominal shipping and handling fees to registered malaria research laboratories worldwide. MR4 is managed through the American Type Culture Collection (ATCC).

40 Exhibitor and Supporter Directory www.astmh.org

National Research Council of the QBC Diagnostics National Academies Contact: Chris Graham Contact: Judith K. Nyquist, PhD 168 Bradford Dr. 500 5th Street NW, Keck 568 Port Malilda, PA 16870 USA Washington, DC 20001 USA Phone: +1-814-692-7661 Phone: +1-202-334-2760 Fax: +1-814-692-7662 Fax: +1-202-334-2759 E-mail: [email protected] E-mail: [email protected] Booth 200 Booth 498 QBC Diagnostics combines point-of-care medicine with The National Research Council of the National Academies advanced tropical disease diagnosis, creating a versitile offers awards in all areas of science and engineering for laboratory package serving remote locations with tropical graduate, postdoctoral and senior research to be conducted health concerns. The QBC Autoread provides a unique, at participating U.S. government laboratories and affi liated simple hematology system, affording a CBC analysis from a institutions. Awards include competitive stipend, relocation, fi nger stick. Combined with the fl uorescent capabilities of the professional travel and health insurance. Detailed information ParaLens, clinicians are provided with the highest level of and application instructions are at: www.national-academies. sensitivity for the diagnosis of many tropical diseases. The QBC org/rap. Annual application deadlines are February 1, May 1, suite of instruments will signifi cantly expand your tropical August 1, November 1. diagnostic capabilities.

Novartis Pharma AG. Paladin Labs, Inc.

Contact: Dr. Nadia elMasry Contact: Farrukh Rehan Forum 1, Novartis Campus 100 Blvd. Alexis Nihon, #600 Basel 4055 St. Laurent, Montreal, Quebec H4M 2P2 Switzerland Canada Phone: +41-61-32-45015 Phone: +1-514-340-1112 Fax: +41-61-32-42146 Fax: +1-514-344-4675 E-mail: [email protected] E-mail: [email protected] Booth 507 Booth 400 Novartis provides healthcare solutions that address the IMPAVIDO, The Breakthrough - Oral Leishmaniasis therapy. evolving needs of patients and societies. Focused solely on healthcare, Novartis offers a diversifi ed portfolio to best Public Library of Science (PLoS) meet these needs: innovative medicines, cost-saving generic pharmaceuticals, preventive vaccines, diagnostic tools Contact: Shabnam Sigman and Mary Kohut and consumer health products. Headquartered in Basel, 185 Berry Street Switzerland, Novartis Group companies employ approximately Suite 3100 99,000 full-time-equivalent associates and operate in more than San Francisco, CA 94107 USA 140 countries around the world. For more information, please Phone: +1-415-624-1200 visit http://www.novartis.com. Fax: +1-415-546-4090 E-mail: [email protected] Novartis Vaccines Booth 501 The Public Library of Science is committed to making the Contact: Laura Wesolowski world’s scientifi c and medical literature a freely available public 350 Massachusetts Ave. resource. All of PLoS’ open access, peer-reviewed journals Cambridge, MA 02319 USA are available to anyone with an internet connection. Shabnam Phone: +1-862-778-6299 Sigman, Publications Manager at PLoS Neglected Tropical E-mail: [email protected] Diseases and Mary Kohut, Publications Manager at PLoS Booth 506 Pathogens, will be at booth 501 to answer your questions. Novartis Vaccines & Diagnostics is a division of Novartis Learn more about our journals and our mission at www.plos. focused on the development of preventive treatments. Novartis org. Vaccines is the world’s fi fth-largest vaccines manufacturer and second-largest supplier of fl u vaccines in the US. The division’s products also include meningococcal, pediatric and travel vaccines.

41 www.astmh.org Exhibitor and Supporter Directory

Royal Society of Tropical Medicine and Hygiene sanofi -aventis

Contact: Gerri McHugh Contact: Frederique Bornier 50 Bedford Square 82 Avenue Raspil London WC1B 3DP 94250 Gentilly United Kingdom France Phone: +44-207-580-2127 Phone: +33-1-41-24-70-00 Fax: +44-207-436-1389 Fax: +33-1-41-24585784 E-mail: [email protected] E-mail: frederique.bornier@sanofi -aventis.com Booth 202 Booth 201 RSTMH promotes and advances the study, control and sanofi -aventis, a leading global pharmaceutical company, prevention of disease in humans and other animals in the discovers, develops and distributes therapeutic solutions to tropics and plays a leading role in increasing awareness of improve the lives of everyone. tropical medicine and international health issues. Through sanofi -aventis is listed in Paris (EURONEXT : SAN) and in our international network of Fellows, we facilitate training, New York (NYSE : SNY). education and exchange of information across all disciplines in the fi eld of tropical medicine and international health. SCYNEXIS, Inc. Fellowship of the RSTMH brings a range of benefi ts including access to our peer-reviewed journals, and a calendar of Contact: Terry Marquardt scientifi c and academic meetings. 3501 C Tricenter Blvd. Durham, NC 27713 USA Rules-Based Medicine, Inc. Phone: +1-919-544-8603 Fax: +1-919-544-8697 Contact: Kay Hallett E-mail: [email protected] 3300 Duval Rd. Booth 601 Austin, TX 78759 USA Phone: +1-703-795-0740 SCYNEXIS is a premier drug discovery and development E-mail: [email protected] company that delivers effective and innovative drug pipeline solutions for human and animal health to pharmaceutical and Booth 307 global health partners on either a fee-for-service or a shared RBM is a biomarker testing laboratory delivering reproducible, risk basis. SCYNEXIS has developed highly productive quantitative, multiplexed immunoassay data. We measure capabilities to discover and develop drug compounds from several to hundreds of proteins in a small sample in multiple early discovery with assay development and screening, through sample types. This provides robust biomarker patterns lead optimization and candidate selection, and beyond proof of for drug development, consumer product and diagnostic concept in humans with cGMP synthesis and manufacturing. applications. RBM is CLIA certifi ed and supports GLP studies. Shin Poong Pharm. Co., LTD.

Salix Pharmaceuticals, Inc. Contact: Dae Woo Hong 748-31 Yoksam-Dong, Kanfnam-Gu Contact: Jason Mitchell Seoul 135-925 1700 Perimeter Park Drive Korea Morrisville, NC 27560 USA Phone: +82-2-2189-3473 Phone: +1-919-862-1000 Fax: +82-2-3452-2866 Fax: +1-919-862-1829 E-mail: [email protected] E-mail: [email protected] Booth 500 Booth 101 Shin Poong has been a major worldwide supplier of API, as Salix Pharmaceuticals, Inc. follows a competitive strategy well as fi nished formulation for mebendazole and albendazole, of in-licensing late-stage pharmaceutical products to treat which are treatments for soil-transmitted helminthiasis, and GI diseases. The Salix portfolio includes APRISO™, praziquantel, which is a treatment for schistosomiasis, through COLAZAL®, XIFAXAN®, OsmoPrep®, MOVIPREP®, public sector business with WHO and World Bank since the AZASAN®, ANUSOL-HC®, PROCTOCORT®, mid-1980s. Major schistosomiasis eradication campaigns PEPCID® Oral Suspension, and DIURIL® Oral Suspension. carried out with praziquantel include Delta project in Egypt Exceptional customer service, a dedicated specialty sales force, and China Project. Also, Shin Poong is developing a new ACT and quality products underscore Salix’s commitment to the anti-malarial drug with Medicines for Malaria Venture (MMV) gastroenterology community. since 1999.

42 Exhibitor and Supporter Directory www.astmh.org

Southern Research Specialized Biocontainment SSGCID and CSGID Structural Screening Center Genomics Services

Contact: Dr. Colleen Jonsson and Nichole Tower Contact: Robin Stacy 2000 Ninth Ave. South 307 Westlake Ave. N Birmingham, AL 35205 USA Suite 500 Phone: +1-205-581-2341 Seattle, WA 98109 USA Fax: +1-205-581-2097 Phone: +1-206-256-7158 E-mail: [email protected] Fax: +1-206-256-7229 Booth 402 E-mail: [email protected] Southern Research Institute was selected as one of nine Booth 208 screening centers in NIH’s Molecular Libraries Probes The NIAID-funded Centers for Infectious Disease (SSGCID Production Center Network for high throughput screening of and CSGID) are soliciting nominations for structure small-molecule compounds. We provide support to the greater determination at no charge to the scientifi c community for scientifi c community in low to high throughput screening in potential drug targets, essential enzymes, virulence factors BSL-2 and BSL-3 environments for live bacterial and viral and vaccine candidates from NIAID priority organisms for agents. We work with assay providers to discover small- biodefense and emerging and re-emerging diseases. Visit booth molecule probes that can be further optimized for higher 208 to learn more (http://ssgcid.org and http://csgid.org/). selectivity and activity against their intended targets. TechLab, Inc. SRI International 2001 Kraft Drive Contact: Regina Tihan Blacksburg, VA 24060-6358 333 Ravenswood Avenue Phone: +1-540-953-1664 Menlo Park, CA 94025 USA Fax: +1-540-953-1665 Phone: +1-650-859-3000 E-mail: [email protected] Fax: +1-650-859-3041 Techlab, Inc. develops, manufactures and distributes rapid E-mail: [email protected] non-invasive intestinal diagnostics in the areas of intestinal Booth 306 infl ammation, antibiotic-associated diarrhea and parasitology. The company continues its research on markers of intestinal SRI International Biosciences provides complete discovery infl ammation, the toxins of Clostridium diffi cile, amebiasis and and preclinical development capabilities to take drugs and vaccine development. TechLab is registered with the U.S. biologics from Idea to IND™. Our integrated program offers Food and Drug Administration and is ISO 13485 certifi ed. the scientifi c, technical and regulatory expertise you need to expedite the process. SRI’s Center for Advanced Drug Research team (Harrisonburg, VA) focuses on improving the productivity of the pharmaceutical industry, helping our nation respond to bio threats, and developing life saving treatments for neglected and orphan diseases. Contact us: [email protected]

43 www.astmh.org Exhibitor and Supporter Directory

University of Pennsylvania Vestergaard Frandsen

University of Pennsylvania Contact: Paul Chen Contact: Omar Harb, PhD 2300 Clarendon Blvd 1403 Blockley Hall Suite 603 Center for Bioinformatics Arlington, VA 22201 USA Philadelphia, PA 10104-6021 Phone: +1-571-527-2180 Phone: +1-215-746-7019 Fax: +1-703-997-3235 Fax: +1-215-573-3111 E-mail: [email protected] E-mail: [email protected] Booth 109 and 111 Booth 407 Vestergaard Frandsen specializes in developing disease control The Eukaryotic Pathogens database (www.EuPathDB.org) is textiles for the prevention of vector-borne (e.g. malaria), water- an integrated database for protozoan pathogens and provides borne (e.g. cholera) and neglected tropical diseases. a functional resource for Cryptosproridium spp., Giardia lamblia, Leishmania spp., Plasmodium spp., Toxoplasma gondii, Trichomonas The Walter Reed Army Institute of Research vaginalis and Trypanosoma spp. EuPathDB provides a venue to analyze and query functional data from each of the maintained Contact: Debra Yourick, PhD organisms, including transcript and protein expression 503 Robert Grant Ave evidence, population biology data (isolates and single Silver Spring, MD 20910 USA nucleotide polymorphisms), gene annotations and orthology Phone: +1-301-319-9471 profi les. E-mail: [email protected] Booth 303 EuPathDB representatives will answer questions, help with The Walter Reed Army Institute of Research (WRAIR) queries and distribute materials. co-develops diagnostics, vaccines and drugs for traumatic injuries and infectious diseases, trauma and operational issues University of Texas Medical Branch -- using human sleep suites; large animal surgery and X-ray; animal BSL-3; pilot GMP vaccine/biological manufacturing; Contact: Dr. Anne-Sophie Brocard, PhD, RBP laboratory/clinical/fi eld trials where tropical diseases are 301 University Blvd. endemic -- to improve soldier health and world health. Galveston, TX 77555 Phone: +1-409-772-8472 E-mail: [email protected] Booth 412 The University of Texas Medical Branch Laboratory Biosafety Training Program (LBT). The LBT program provides laboratory and support staff training in BSL2 to 4 laboratory biosafety. The program offers extensive one on one customized hands-on training and theoretical classes. These courses allow staff to enter into mentorship with the appropriate skills to understand biocontainment, work safely and use good laboratory practices.

Web: www.utmb.edu/biosafetytraining Email: [email protected]

44 ASTMH 58th Annual Meeting www.astmh.org

Tuesday, November 17 10:45 a.m. THE INTESTINAL MICROBIOTA: ITS ROLE IN HEALTH Pre-Meeting Course Registration AND DISEASE (PART 2) Cathy Lozupone Salon Foyer University of Colorado, Boulder, CO, United States Tuesday, November 17, 7 a.m. - 1:30 p.m. 11:30 a.m. Tuesday, November 17 Basic Science Pre-Meeting Course LUNCH (ON YOUR OWN)

The Intersection of Nutrition and Infectious Disease: 1 p.m. Challenges and Opportunities for Studying Nutrition- NEW APPROACHES TO IDENTIFY ENTERIC PATHOGENS Disease Interactions in the Developing World Eric R. Houpt University of Virginia, Charlottesville, VA, United States Washington 4 1:30 p.m. Tuesday, November 17, 8:30 a.m. – 5 p.m. UNDERNUTRITION, MICRONUTRIENTS AND IMMUNE This course will target scientists, physicians, clinicians, graduate students FUNCTION and educators who wish to gain a better understanding of the consequences of undernutrition on infectious disease and other health outcomes, as well Margherita Cantorna as an understanding of how infection contributes to nutritional defi ciencies. Pennsylvania State University, University Park, PA, United States Topics will include: an overview of the burden of malnutrition and enteric 2 p.m. diseases in the developing world tools; technologies to identify normal gut fl ora and intestinal pathogens; nutrition and immune function and infl ammation; THE NEWBORN MEETS THE MICROBIAL WORLD: maternal-child interactions; nutrition, infection and child development; and MOTHER-CHILD INTERACTIONS AND PROTECTION opportunities for interventions. FROM INFECTION (BREASTFEEDING, ETC.) CHAIR Lars Hanson Goteborg University, Goteborg, Sweden Daniel J. Carucci United Nations Foundation, Washington, DC, United States 2:30 p.m. Laura Caulfi eld REFRESHMENT BREAK Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, United States 3 p.m. Michael Gottlieb Foundation for the National Institutes of Health, Bethesda, MD, United States GUT FUNCTION, SIGNALING AND REPAIR Fang Yan 8:30 a.m. Vanderbilt University Medical Center, Nashville, TN, United States LIGHT CONTINENTAL BREAKFAST 3:45 p.m. 9 a.m. PRE- AND PROBIOTICS: NUTRITIONAL PROPERTIES INTRODUCTION - COURSE GOALS AND OUTLINE AND PHYSIOLOGICAL Daniel J. Carucci Speaker to be announced United Nations Foundation, Washington, DC, United States 4 p.m. Laura Caulfi eld Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, United NUTRITION, INFECTION AND CHILD DEVELOPMENT States Susan Walker Michael Gottlieb University of West Indies, Mona, Kingon, Jamaica Foundation for the National Institutes of Health, Bethesda, MD, United States 4:30 p.m. 9:15 a.m. WRAP-UP THE BURDEN OF NUTRITIONAL DEFICIENCIES AND Daniel J. Carucci ENTERIC DISEASES IN THE DEVELOPING WORLD United Nations Foundation, Washington, DC, United States Laura Caulfi eld Michael Gottlieb Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, United Foundation for the National Institutes of Health, Bethesda, MD, United States States 10 a.m. THE INTESTINAL MICROBIOTA: ITS ROLE IN HEALTH AND DISEASE (PART 1) Andrew Goodman Washington University, St. Louis, MO, United States

45 www.astmh.org Detailed Program

Clinical Pre-Meeting Course 5:15 p.m. SUMMARY/REVIEW The Highly-Prevalent Neglected Tropical Diseases (NTDs): Peter J. Hotez Update on Clinical Aspects and Novel Approaches to The George Washington University and Sabin Vaccine Institute, Washington, DC, Control United States Salon 1 Wednesday, November 18 Tuesday, November 17, 1 p.m. - 5:30 p.m. The neglected tropical diseases (NTDs) are a group of chronic infections Clinical Pre-Meeting Course whose major impact is in producing signifi cant disability and suffering in those affected, who primarily consist of the world’s poorest people. The most prevalent NTDs include the soil-transmitted helminths (ascariasis, trichuriasis, The Highly Prevalent Neglected Tropical Diseases (NTDs): hookworm infection), schistosomiasis, lymphatic fi lariasis, trachoma and Update on Clinical Aspects and Novel Approaches to onchocerciasis. More recently, the food-borne trematodes (opisthorchiasis, Control clonorchiasis, fascioliasis, paragonimiasis) have emerged as important causes of morbidity in several areas of the world. Over one billion people are Salon 1 currently infected with at least one of these NTDs, and many are concurrently Wednesday, November 18, 7:30 a.m. - 3 p.m. affected by more than one. Reduction of disease burden or interference with transmission of NTDs would have both immediate impact on global health and longer-term effects on economic growth and development. The course 7:30 a.m. will provide updates on the highly-prevalent NTDs listed above, with special LIGHT CONTINENTAL BREAKFAST emphasis on the latest innovations in diagnosis and treatment, as well as current control strategies, including efforts at integration of interventions. 8 a.m. In addition, updates will be provided on the state of current research on new SCHISTOSOMIASIS: CONTROL UPDATE control drugs, diagnostic materials, insecticides and vaccines. For each of the highlighted NTDs, the presentation will be divided into two parts: an update Alan Fenwick on the clinical aspects of the disease and an update on the latest and future Imperial College, London, United Kingdom control strategies. 8:45 a.m. CHAIR LYMPATHIC FILARIASIS: CLINICAL UPDATE Peter J. Hotez Thomas B. Nutman The George Washington University and Sabin Vaccine Institute, Washington, DC, National Institutes of Health, Bethesda, MD, United States United States David J. Diemert 9:30 a.m. The George Washington University and Sabin Vaccine Institute, Washington, DC, LYMPHATIC FILARIASIS: CONTROL UPDATE United States Eric A. Ottesen 1 p.m. Task Force for Global Health, Decatur, GA, United States INTRODUCTION AND OVERVIEW: THE HIGHLY- 10:15 a.m. PREVALENT NTDS REFRESHMENT BREAK Peter J. Hotez The George Washington University and Sabin Vaccine Institute, Washington, DC, 10:30 a.m. United States ONCHOCERCIASIS: CLINICAL UPDATE 1:30 p.m. David O. Freedman SOIL-TRANSMITTED HELMINTHS University of Alabama at Birmingham, Birmingham, AL, United States David J. Diemert 11:15 a.m. The George Washington University and Sabin Vaccine Institute, Washington, DC, United States ONCHOCERCIASIS: CONTROL UPDATE Thomas R. Unnasch 3 p.m. University of South Florida, Tampa, FL, United States REFRESHMENT BREAK Noon 3:30 p.m. LUNCH (ON YOUR OWN) FOOD-BORNE TREMATODES 1 p.m. Paul J. Brindley The George Washington University and Sabin Vaccine Institute, Washington, DC, TRACHOMA: CLINICAL UPDATE United States David Mabey London School of Hybiene and Tropical Medicine, London, United Kingdom 4:30 p.m. SCHISTOSOMIASIS: CLINICAL UPDATE 1:45 p.m. Christopher L. King TRACHOMA: CONTROL UPDATE Case Western Reserve University, Cleveland, OH, United States Paul Emerson The Carter Center, Atlanta, GA, United States

46 ASTMH 58th Annual Meeting www.astmh.org

2:30 p.m. 328 WRAP-UP: REGIONAL APPROACHES TO NTD CONTROL CORRELATION OF DERMATOLOGICAL Patrick J. Lammie Centers for Disease Control and Prevention, Atlanta, GA, United States AND OPHTHALMOLOGICAL MORBIDITY IN ONCHOCERCIASIS (FOREST TYPE) ASTMH Council Meeting Luc E. Coffeng1, Wilma A. Stolk1, Sake J. de Vlas1, Michel Boussinesq2, Grace N.A. Fobi2, Gladys A. Ozoh2, Peter A. Enyong2, Anne-Cécile Z.K. Wilson AB Bissek2, Dik J.D.F. Habbema1 1Erasmus Medical Center, Rotterdam, The Netherlands, 2African Programme for Wednesday, November 18, 8 a.m. - 3 p.m. Onchocerciasis Control, Ouagadougou, Burkina Faso Media Room 659 Rooms 8228/8229 Wednesday, November 18, 8 a.m. - 4 p.m. STIMULATION OF MONOCYTES BY FILARIAL Registration EXCRETORY-SECRETORY PRODUCTS: A POTENTIAL ROLE IN MODULATION OF THE LYMPHATIC Salon Foyer ENDOTHELIUM? Wednesday, November 18, 9:30 a.m. - 6 p.m. Tiffany S. Weinkopff1, Patrick Lammie2 1University of Georgia, Athens, GA, United States, 2Centers for Disease Control and ACAV SIE Subcommittee Meeting Prevention, Atlanta, GA, United States Wednesday, November 18

Room 8219 1084 Wednesday, November 18, 11 a.m. - Noon PATENT FILARIAL INFECTION MODULATES THE Young Investigator Award Presentations QUALITY OF T CELL RESPONSES TO MALARIAL ANTIGENS IN MALARIA/FILARIAL CO-ENDEMIC In Honor of William A. Petri, Sr. VILLAGE OF MALI In Memory of Annie Liberati Simon Metenou1, Benoit Dembele2, Siaka Konate2, Housseini Dolo2, Lamine Supported with funding from TechLab, Inc. Soumaoro2, Abdallah A. Diallo2, Michel E. Coulibaly2, Siaka Y. Coulibaly2, Dramane Sanogo2, Yaya I. Coulibaly2, Sekou F. Traore2, Siddhartha ASTMH will present the Young Investigator Award to outstanding young Mahanty1, Amy D. Klion1, Thomas B. Nutman1 researchers during the 58th Annual Meeting. This award encourages 1National Institutes of Health, Bethesda, MD, United States, 2Filaria Unit, FMPOS, developing young scientists to pursue careers in various aspects of tropical University of Bamako, Mali, Bamako, Mali disease research. 672 Young Investigator Award Session A DECODING THE INVASION AND MOLTING PROCESSES Jackson OF BRUGIA MALAYI L3 LARVAE Wednesday, November 18, 11 a.m. - 3:30 p.m. Sasisekhar Bennuru, Thomas B. Nutman JUDGES National Institutes of Health, Bethesda, MD, United States Stephen Davies 468 Uniformed Services University of the Health Sciences, Bethesda, MD, United States Edward Mitre A NOVEL AND POWERFUL CLASS OF NEMATICIDES National Institutes of Health, Bethesda, MD, United States FOR SOIL-TRANSMITTED NEMATODE INFECTIONS Daniel J. Tisch Yan Hu, Sophia Georghiou, Alan Kelleher, Cheng-Yuan Kao, Chang-Shi Case Western Reserve University, Cleveland, OH, United States Chen, Raffi V. Aroian Patricia Wilkins University of California, San Diego, La Jolla, CA, United States Centers for Disease Control and Prevention, Atlanta, GA, United States 1118 1140 INSECTICIDE TREATED NETS IN MALARIA PROLONGED DIARRHEA IN A BRAZILIAN COMMUNITY PREVENTION: DOES DISTRIBUTION MODEL MATTER? BIRTH COHORT: EPIDEMIOLOGY, ETIOLOGIES, Hannah Chiu, Michael Hawkes, Kevin Kain NUTRITIONAL IMPACT, AND LINKS TO PERSISTENT University of Toronto, Toronto, ON, Canada DIARRHEA Sean R. Moore1, Noélia L. Lima2, Reinaldo B. Oriá2, Relana C. Pinkerton3, 1129 Alberto M. Soares2, Richard L. Guerrant3, Aldo A. Lima2 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 2Federal PURINERGIC SIGNALING AND IMMUNE MODULATION 3 University of Ceará, Fortaleza, Brazil, University of Virginia, Charlottesville, VA, AT THE SCHISTOSOME SURFACE United States Rita Bhardwaj, Patrick J. Skelly Tufts Cummings School of Veterinary Medicine, North Grafton, MA, United States

47 www.astmh.org Detailed Program

707 19

INTEGRATED CONTROL STRATEGIES OF ANALYSIS OF ANOPHELES ARABIENSIS BLOOD FEEDING SCHISTOSOMIASIS TRANSMISSION INFORMED BY A BEHAVIOR IN SOUTHERN ZAMBIA DURING THE BAYESIAN MULTILEVEL MODEL AT A LOCAL SCALE TWO YEARS FOLLOWING THE INTRODUCTION OF Kun Yang INSECTICIDE TREATED BED NETS College of Public Health, The Ohio State University, Columbus, OH, United States Christen M. Fornadel1, Shadreck Habbanti2, Laura C. Norris1, Douglas E. Norris1 697 1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 2Malaria Institute at Macha, Choma, Zambia MOLECULAR SIGNALING DURING THE MIRACIDIUM TO SPOROCYST TRANSFORMATION IN SCHISTOSOMA 1040 MANSONI PRESUMPTIVE TREATMENT INCREASES RISK OF Andrew S. Taft, Francesca Norante, Timothy P. Yoshino University of Wisconsin, Madison, Madison, WI, United States INFLAMMATION AND POOR FETAL OUTCOMES IN WOMEN WITH PLACENTAL MALARIA AT DELIVERY 347 Whitney E. Harrington1, Edward Kabyemela1, Atis Muehlenbachs1, Kathryn Williamson1, Theonest K. Mutabingwa2, Michal Fried1, Patrick E. Duffy1 IN UTERO EXPOSURE TO MATERNAL SCHISTOSOMIASIS 1Seattle Biomedical Research Institute, Seattle, WA, United States, 2National Institute of Medical Research, Dar es Salaam, United Republic of Tanzania MODULATES ACUTE AND MEMORY CELLULAR AND HUMORAL IMMUNE RESPONSES OF OFFSPRING Allison C. Brown, William J. Moss Young Investigator Award Session B The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States Jefferson 409 Wednesday, November 18, 11 a.m. - 3:30 p.m. JUDGES CLINICAL FACTORS PREDICTIVE OF ENCEPHALITIS CAUSED BY ANGIOSTRONGYLUS CANTONENSIS Kathryn S. Aultman Bill & Melinda Gates Foundation, Seattle, WA, United States Kittisak Sawanyawisuth1, Ken Takahashi2, Tsutomu Hoshuyama2, Kanlayanee Sawanyawisuth1, Vichai Senthong1, Panita Limpawattana1, Lyric C. Bartholomay Donald Wilson2, Somsak Tiamkao1, Suthipun Jitpimolmard1, Verajit Iowa State University, Ames, IA, United States Chotmongkol1 Brenda T. Beerntsen 1Khon Kaen University, Khon Kaen, Thailand, 2University of Occupational and University of Missouri-Columbia, Columbia, MO, United States Environmental Health, Kitakyushu, Japan Julian F. Hillyer Vanderbilt University, Nashville, TN, United States 476 Nicholas Komar Centers for Disease Control and Prevention, Fort Collins, CO, United States PREVIOUS EXPOSURE WITH CEPHALOSPORINS AND MACROLIDES BUT NOT COTRIMOXAZOLE AS A RISK 1110 FACTOR FOR COLONIZATION WITH MRSA IN HIV- INFECTED CHILDREN MEK/ERK SIGNALING AND REACTIVE OXYGEN SPECIES Andrea Kalavska, Vladimir Krcmery, Anna Liskova REGULATE THE MOSQUITO ANTI-MALARIAL IMMUNE St. Elizabeth University College of Health and Social Sciences, Bratislava, Slovakia RESPONSE Win Surachetpong, Shirley Luckhart 246 University of California Davis, Davis, CA, United States

BED NET COVERAGE, USAGE AND CONDITION IN 231 FISHING VILLAGES OF SUBA DISTRICT, WESTERN KENYA USING ENHANCED REPRODUCTION AS A NOVEL Gabriel O. Dida1, George O. Sonye2, H. Horio3, S. Kaneko3, M. Shimada3, F. DRIVE MECHANISM FOR MOSQUITO POPULATION Kyoko3, N. Minakawa3 REPLACEMENT 1School of Public Health, Maseno University, Kisumu, Kenya, 2International Centre of 1 2 1 1 Insect Physiology and Ecology, Mbita, Kenya, 3Institute of Tropical Medicine, Nagasaki Anam Javed , Jason L. Rasgon , Kendra M. Quicke , Michael A. Riehle 1 2 University, Nagasaki, Japan University of Arizona, Tucson, AZ, United States, Johns Hopkins University, Baltimore, MD, United States 10 240 PREDICTED EFFECTS OF HOST RESERVOIR-TARGETED AN EVOLUTIONARY CONSERVED FUNCTION OF THE VACCINATION ON LYME DISEASE RISK JAK-STAT PATHWAY IN ANTI-DENGUE DEFENSES Kimberly Tsao, Durland Fish, Alison Galvani Yale University, New Haven, CT, United States Jayme A. Souza-Neto, George Dimopoulos Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States

48 ASTMH 58th Annual Meeting www.astmh.org

1090 592

INSENSITIVE ACETYLCHOLINESTERASE (ACE.1R): ASSESSING RISK IN FOCAL ARBOVIRAL INFECTIONS: EVENTS OF INTROGRESSION AND DUPLICATION ARE WE MISSING THE BIG OR LITTLE PICTURE? BETWEEN THE MOLECULAR M AND S FORMS OF Andrew D. Haddow1, Carl J. Jones2, Reid R. Gerhardt2, Agricola R. Odoi2 ANOPHELES GAMBIAE S.S. 1University of Texas Medical Branch, Galveston, TX, United States, 2University of Luc S. Djogbénou1, Mylène Weill2, Jean-Marc Hougard3, Fabrice Chandre3, Tennessee, Knoxville, TN, United States Roch Dabire4 1Institut Régional de Santé Publique/IRD, Cotonou, Benin, 2Equipe Génétique de 737 l’Adaptation/Université Montpellier, Montpellier, France, 3Institut de Recherche pour le Developpement, Montpellier, France, 4Institut Régional des Sciences de Santé, Bobo- INVESTIGATIONS OF CLOSE CONTACTS OF PATIENTS Dioulasso, Burkina Faso WITH LABORATORY-CONFIRMED H5N1 INFECTION IN INDONESIA, IN 2007 363 Vivi Setiawaty, Siti Isfandari, Ni Ketut Susilarini, Krisnanur A. Pangesti, Endang R. Sedyaningsih DUPLICATION AND CONCERTED EVOLUTION OF National Institute of Health Research and Development, Jakarta, Indonesia VITELLOGENIN GENES IN MOSQUITOES Song Chen, Jason L. Rasgon 733 Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United

States ANTIGENIC AND PHYLOGENETIC ANALYSIS OF Wednesday, November 18 INFLUENZA VIRUSES IN KENYA FROM 2006-08 WITHIN 360 THE CONTEXT OF REGIONAL AND GLOBAL INFLUENZA DRIFT THE EFFECT OF GENE DRIVE ON CONTAINMENT OF 1 2 2 3 TRANSGENIC MOSQUITOES David Schnabel , Wallace Bulimo , Rachel Achilla , Tom Gibbons , Scott Gordon1 John M. Marshall 1United States Army Medical Research Unit - Kenya, Nairobi, Kenya, 2Kenya Medical University of California at Los Angeles, Los Angeles, CA, United States Research Institute, Nairobi, Kenya, 3United States Air Force School of Aerospace Medicine, Brooks City-Base, TX, United States 255 687 BIOLOGICAL DIVERSITY AND GENE POLYMORPHISMS ASSOCIATED WITH KNOCKDOWN RESISTANCE IN PREVENTING NIPAH VIRUS TRANSMISSION: MEMBERS OF THE PAPUA NEW GUINEA ANOPHELES UNDERSTANDING EFFICACY OF BAMBOO SKIRT TO PUNCTULATUS SPECIES COMPLEX IMPEDE DATE PALM SAP CONTAMINATION BY BATS Cara N. Henry-Halldin1, Kogulan Nadesakumaran1, Daphne Sepe2, John M. S. Khan1, Emily S. Gurley1, Md. Jahangir Hossain1, Nazmun Nahar1, B. Keven2, Laurie Gray1, Lisa Reimer1, Nigel W. Beebe3, Robert D. Cooper4, Stephen P. Luby2 Peter A. Zimmerman1 1International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, 1Case Western Reserve University, Cleveland, OH, United States, 2Papua New Guinea 2Centers for Disease Control and Prevention, Atlanta, GA, United States Institute of Medical Research, Madang, Papua New Guinea, 3School of Integrative Biology, University of Queensland, St. Lucia, Australia, 4Australian Army Malaria 731 Institute, Enoggera, Australia SPATIAL ANALYSIS OF HEMORRHAGIC FEVER WITH 586 RENAL SYNDROME IN SHANDONG PROVINCE, EASTERN CHINA, 1968-2005 OVIPOSITION SITE SELECTION IN THE DENGUE 1 2 3 4 VECTOR, AEDES AEGYPTI Li-Qun Fang , Song Liang , Xian-Jun Wang , Sake J. de Vlas , Zhi-Qiang Wang3, Shao-Xia Song3, Wen-Yi Zhang1, You-Fu Xu1, Hong Yang1, Wu- Jacklyn Wong, Amy C. Morrison, Helvio Astete, Steven T. Stoddard, Chun Cao1 Thomas W. Scott 1Beijing Institute of Microbiology and Epidemiology, Beijing, China, 2The Ohio State University of California, Davis, Davis, CA, United States University, Columbus, OH, United States, 3Shandong Center for Disease Control and Prevention, Jinan, China, 4Department of Public Health, University of Medical Center 250 Rotterdam, Rotterdam, The Netherlands

TRAPPING MALARIA VECTORS USING SYNTHETIC 689 ODORS THAT ARE MORE ATTRACTIVE THAN HUMANS Fredros O. Okumu ISOLATION AND PHYLOGENETIC ANALYSIS Ifakara Health Institute, Ifakara, Morogoro region, United Republic of Tanzania OF MUCAMBO VIRUS (VENEZUELAN EQUINE ENCEPHALITIS COMPLEX SUBTYPE IIIA) IN TRINIDAD 590 Auguste J. Auguste1, Sara Volk2, Nicole Arrigo2, Raymond Martinez1, Vernie Ramkissoon1, A. Paige Adams2, Abiodun Adesiyun1, Dave Chadee1, Jerome BIOACOUSTICS AND COURTSHIP IN AEDES AEGYPTI Foster1, Amelia Travassos Da Rosa2, Robert Tesh2, Scott Weaver2, Christine AND ANOPHELES GAMBIAE V. Carrington1 1The University of the West Indies, St. Augustine, Trinidad and Tobago, 2University of Lauren J. Cator, Ronald R. Hoy, Laura C. Harrington Texas Medical Branch, Galveston, TX, United States Cornell University, Ithaca, NY, United States

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SARS CORONAVIRUS ADAPTATION TO HUMAN IS GENETIC MAPPING IN TWO P. FALCIPARUM CROSSES PARTIALLY CONSTRAINED BY HOST ALTERATION IDENTIFIES A LOCUS ENCODING THE PLASMODIAL Xianchun Tang1, Nikos Vasilakis2, Zhenli Shi3, Yang Zhong4, Lin-fa Wang5, SURFACE ANION CHANNEL Shuyi Zhang1 Abdullah A. Bokhari, Sanjay A. Desai 1School of Life Science, East China Normal University, Shanghai, China, 2Center for National Institute of Allergy and Infectious Diseases, National Institutes of Health, Vaccine Research, University of Pittsburgh, Pittsburgh, PA, United States, 3Institute of Rockville, MD, United States Virology, Chinese Academy of Sciences, Wuhan, China, 4School of Life Sciences, Fudan University, Shanghai, China, 5Australian Animal Health Laboratory and Australian 341 Biosecurity Cooperative Research Centre, Geelong, Australia

1015 MAPPING THE GENETIC CONTROL OF THE GLOBAL METABOLITE PROFILE IN PLASMODIUM FALCIPARUM EFFICIENCY AND RELIABILITY OF RBCL AND CRCL3 Mark A. Wacker1, Kellen A. Olszewski2, Asako Tan1, Geoffrey H. Siwo1, 3 2 1 IN MARKING TRIATOMA BRASILIENSIS NYMPHS: Joshua D. Rabinowitz , Maneul Llinas , Michael T. Ferdig 1Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United PERSISTENCE AND INFLUENCE OF TRACE ELEMENTS States, 2Department of Molecular Biology and Lewis-Singler Institute for Integrative ON INSECT BIOLOGY Genomics, Princeton University, Princeton, NJ, United States, 3Department of Chemistry Rafael M. Freitas, Otilia Sarquis, Livia S. Oliveira, Jailey M. Gonçalves, and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, Reginalo L. Rego, Marli M. Lima United States Oswaldo Cruz Foundation, Rio de Janeiro, Brazil 842 762 DISRUPTION OF LIPOYLATION IN THE P. FALCIPARUM DEMONSTRATION OF PARATRANSGENIC MITOCHONDRION AND APICOPLAST IS LETHAL PHLEBOTOMUS ARGENTIPES Maroya D. Spalding, Sean T. Prigge Heidi Hillesland1, Ivy Hurwitz1, Rajesh Kumar2, Ravi Durvasula1, Vijay Johns Hopkins School of Public Health, Baltimore, MD, United States Kumar2, Pradeep Das2, Annabeth Fieck1 1University of New Mexico, Albuquerque, NM, United States, 2Rajendra Memorial 159 Research Institute of Medical Sciences, Patna, India TARGETING PFHSP90 IN PLASMODIUM FALCIPARUM Young Investigator Award Session C MALARIA: A STRATEGY TO REVERSE RESISTANCE Dea Shahinas1, Gabriela Chiosis2, Dylan R. Pillai1 Johnson 1University of Toronto, Toronto, ON, Canada, 2Memorial Sloan Kettering Cancer Wednesday, November 18, 11 a.m. - 3:30 p.m. Center, New York, NY, United States

JUDGES 892 Roland A. Cooper Old Dominion University, Norfolk, VA, United States MOLECULAR CHARACTERIZATION OF RESISTANCE TO Rick Fairhurst ARTEMISININ DRUGS IN PLASMODIUM FALCIPARUM National Institutes of Health, Bethesda, MD, United States Matthew S. Tucker1, Lucia Gerena2, Katherine Sorber3, Michelle Dimon3, 1 2 4 1 Christine Petersen Azliyati Azizan , Zhinning Wang , Qin Cheng , Dennis E. Kyle 1 2 Iowa State University, Ames, IA, United States University of South Florida, Tampa, FL, United States, Walter Reed Army Institute of Research, Rockville, MD, United States, 3University of California-San Francisco, San Julian C. Rayner Francisco, CA, United States, 4Australian Army Malaria Institute, Enoggera, Australia University of Alabama at Birmingham, Birmingham, AL, United States 747 1146 CALCULATING DRUG NEEDS AND COSTS FOR GENOMIC INSIGHTS INTO LEPTOSPIRAL TREATING VISCERAL LEISHMANIASIS IN THE INDIAN PATHOGENESIS SUBCONTINENT AND AFRICA USING LOCAL PATIENT Jessica Ricaldi, Michael A. Matthias, Joseph Vinetz ANTHROPOMETRIC DATA University of California San Diego, San Diego, CA, United States Michael O. Harhay1, François Chappuis2, Suman Rijal3, Shyam Sundar4, Piero L. Olliaro5 1University of Pennsylvania, Philadelphia, PA, United States, 2Geneva University Hospitals, Travel and Migration Medicine Unit, Geneva, Switzerland, 3BP Koirala Institute of Health Sciences, Dharan, Nepal, 4Institute of Medical Sciences, Banaras Hindu University, Varanasi, India, 5UNICEF/UNDP/World Bank/WHO Special Programme on Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland

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49 Young Investigator Award Session D

GENOME ORGANIZATION OF TANDEMLY-REPETITIVE Taylor DNA IN IXODES SCAPULARIS, THE LYME DISEASE TICK Wednesday, November 18, 11 a.m. - 3:30 p.m. Jason M. Meyer1, Timothy J. Kurtti2, Catherine E. Silva1, Janice P. VanZee1, JUDGES Catherine A. Hill1 1Purdue University, Lafayette, IN, United States, 2University of Minnesota, St. Paul, Brian Grimberg MN, United States Case Western Reserve University, Cleveland, OH, United States Sanjai Kumar 493 Food and Drug Administration, Rockville, MD, United States Miriam Laufer IDENTIFYING MICRORNAS THAT ALTER MACROPHAGE University of Maryland, Baltimore, MD, United States SUSCEPTIBILITY TO INFECTION BY LEISHMANIA Peter Zimmerman Joel W. Graff, Anne M. Dickson, Mary E. Wilson Case Western Reserve University, Cleveland, OH, United States University of Iowa, Iowa City, IA, United States 2 127 MULTIPLE GENETIC BACKGROUNDS OF THE ISOLATED AND PURIFIED NOVEL ANTILEISHMANIAL AMPLIFIED PLASMODIUM FALCIPARUM MULTIDRUG

DRUG CANDIDATE FROM HIMATANTHUS SUCUUBA RESISTANCE (PFMDR1) GENE AND SELECTIVE SWEEP Wednesday, November 18 Renzo Perales, Jorge Arevalo OF 184F MUTATION IN CAMBODIA Instituto de Medicina Tropical “Alexander von Humboldt”, Lima, Peru Sumiti Vinayak1, Md Tauqeer Alam2, Rithy Sem3, Naman K. Shah4, Augustina I. Susanti5, Pharath Lim6, Sinuon Muth3, Jason D. Maguire5, 497 William O. Rogers5, Thierry Fandeur7, John W. Barnwell2, Ananias A. Escalante8, Chansuda Wongsrichanalai5, Frederick Ariey6, Steven R. 4 2 EVALUATION OF INHIBITORY EFFECT OF A Meshnick , Venkatachalam Udhayakumar 1Atlanta Research and Education Foundation and Malaria Branch, Division of Parasitic TRYPANOSOMA BRUCEI CALCIUM CHANNEL ANTIBODY Diseases, National Center for Zoonotic Vector-Borne and Enteric Diseases, Coordinating (ANTI-TBCC1) IN VITRO Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, Kiantra I. Ramey1, Zuzana Kucerova2, Winston Thompson1, Jonathan K. United States, 2Malaria Branch, Division of Parasitic Diseases, National Center for Stiles1 Zoonotic Vector-Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, 1Morehouse School of Medicine, Atlanta, GA, United States, 2Centers for Disease Control Centers for Disease Control and Prevention, Atlanta, GA, United States, 3National and Prevention, Atlanta, GA, United States Malaria Center, Phnom Penh, Cambodia, 4Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC, United States, 5United States 662 Naval Medical Research Unit No. 2, Jakarta, Indonesia, 6Institut Pasteur in Cambodia, Phnom Penh, Cambodia, 7Institut Pasteur, Unité d’Immunologie Moléculaire des Parasites, Paris, France, 8School of Life Sciences, Arizona State University, Tempe, AZ, PHOSPHATIDYLSERINE EXPOSURE BY AMASTIGOTES United States OF LEISHMANIA AMAZONENSIS IS INDUCED BY HOST IMMUNE RESPONSES 149 Joao L. Wanderley1, Poliana Deolindo2, Marcello Barcinski3, Lynn Soong4 1Federal University of Rio de Janeiro, Morphological Sciences Program, Rio de Janeiro, INTERMITTENT PREVENTIVE TREATMENT USING 2 3 Brazil, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, University of Sao Paulo, Sao ARTEMISININ-BASED COMBINATION THERAPY Paulo, Brazil, 4University of Texas Medical Branch, Galveston, TX, United States REDUCES MALARIA MORBIDITY AMONG SCHOOL- 782 AGED CHILDREN IN MALI Hamma Maiga1, Breanna Barger2, Oumar Bila Traore1, Mamadou Tekete1, 1 1 1 3 INVESTIGATING NOVEL DENGUE VIRUS INFECTION Antimbe Timbine , Antoine Dara , Zoumana Isaac Traore , Soren Gantt , Ogobara Doumbo1, Abdoulaye Djimde1 BIOMARKERS USING PROTEOMIC METHODS: 1MRTC/DEAP, Bamako, Mali, 2University of Washington, Seattle, WA, United States, VITRONECTIN PRECURSOR PROTEIN AS A NEW LEAD 3Department of Pediatrics, Seattle Children’s Hospital, WA, United States Alexa Gilbert1, Takol Takol Chareonsirisuthigul2, Sukathida Ubol2, Brian J. Ward1, Momar Ndao1 893 1McGill University, Montreal, QC, Canada, 2Mahidol University, Bangkok, Thailand ANTI-MALARIAL TREATMENT REGIMES FROM AN 284 EVOLUTIONARY PERSPECTIVE Silvie Huijben, Derek Sim, Brian Chan, Danielle Tomasello, Andrew Read SCHISTOSOMA MANSONI PKA: A POTENTIAL NEW DRUG The Pennsylvania State University, University Park, PA, United States TARGET Brett E. Swierczewski, Stephen J. Davies Uniformed Services University of the Health Sciences, Bethesda, MD, United States

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SELECTION OF KNOWN RESISTANCE-MEDIATING GENETIC DIVERSITY IN THE P. FALCIPARUM AND P. POLYMORPHISMS BY ARTEMETHER-LUMEFANTRINE VIVAX MALARIA CELTOS GENE FROM SOUTHEAST AND AMODIAQUINE/SULFADOXINE-PYRIMETHAMINE, ASIA, AFRICA, AND SOUTH AMERICA REVEALS A BUT NOT BY DIHYDROARTEMISININ-PIPERAQUINE IN HIGHLY CONSERVED GENE WITH FOCAL REGIONS BURKINA FASO OF NON-SYNONOMOUS MUTATIONS UNDER IMMUNE Anyirekun Fabrice Some1, Yves Sere1, Issaka Zongo1, Noel Rouamba1, Chris SELECTIVE PRESSURE CONFIRMED BY GENE 2 2 2 2 Dokomajilar , Bryan Greenhouse , Jenny Legac , Shoba Subramanian , Jean- SEQUENCING, 3D STRUCTURE PREDICTION AND Bosco Ouedraogo1, Philip J. Rosenthal2 1Institut de Recherche en Sciences de la Sante, Bobo-Dioulasso, Burkina Faso, PEPTIDE MAPPING 2Department of Medicine, University of California, San Francisco, CA, United States Eric B. Ockenhouse1, Elke Bergmann-Leitner2, Matthew Riley2, Jonathan D’Ambrozio3, M. Lee4, X. Hu4, Anders Wallqvist4, Paul Graf5, John Waitumbi6, Evelina Angov2, Christian F. Ockenhouse2 1Bethesda-Chevy Chase High School-Walter Reed Army Institute of Research, Silver 1044 Spring, MD, United States, 2USMMVP-Walter Reed Army Institute of Research, Silver Spring, MD, United States, 3Walter Reed Army Institute of Research, Silver Spring, DETECTION AND VALIDATION OF COMPLEMENT MD, United States, 4TATRC, MRMC, Frederick, MD, United States, 5Naval Medical COMPONENT C3A AS A NOVEL BIOMARKER FOR Research Center Detachment-Peru, Lima, Peru, 6USAMRU-Kenya, Kisumu, Kenya CEREBRAL MALARIA 905 Sarah J. Higgins, Karlee Silver, Shehzad Iqbal, Samir Patel, Kathleen Zhong, Andrea Conroy, Kevin C. Kain McLaughlin-Rotman Centre for Global Health University of Toronto, Toronto, ON, THE LONGITUDINAL PROROGATION OF COMPLEX P. Canada FALCIPARUM INFECTIONS CULTIVATES GENETICALLY DISTINCT CLONAL POPULATIONS 139 Patrick L. Sutton1, Lindsay Prado Torres2, Claudia Silva2, OraLee Branch1 1New York University, New York, NY, United States, 2Universidad Nacional de la DYSREGULATION OF ANGIOPOIETINS IN LOW BIRTH Amazonia Peruana, Iquitos, Peru WEIGHT OUTCOMES OF PLACENTAL MALARIA Karlee L. Silver1, Kathleen Zhong1, Rose G. Leke2, Diane Wallace Taylor3, 911 Kevin C. Kain1 1McLaughlin-Rotman Centre for Global Health/University of Toronto, Toronto, ANTIBODIES AGAINST THE ERYTHROCYTE BINDING ON, Canada, 2University of Yaounde, Yaounde, Cameroon, 3Georgetown University, ANTIGENS OF PLASMODIUM FALCIPARUM ARE STRONGLY Washington, DC, United States ASSOCIATED WITH PROTECTION AGAINST CLINICAL MALARIA AND HIGH PARASITEMIA 1031 Jack S. Richards1, Danielle I. Stanisic2, Pascal Michon2, Elijah Dabod2, Chetan E. Chitnis3, David E. Narum4, Jennifer K. Thompson1, Alan F. BIOLOGICAL AND CLINICAL IMMUNITY TO MALARIA Cowman1, Ivo Mueller2, James G. Beeson1 INCREASE WITH AGE IN KENYAN HIGHLAND AREAS 1Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, 2Papua New WITH UNSTABLE TRANSMISSION Guinea Institute of Medical Research, Madang, Papua New Guinea, 3International 4 Melissa A. Riedesel1, Matthew McCarra1, Ng’wena G. Magak2, Kacey C. Centre for Genetic Engineering and Biotechnology, New Delhi, India, National Institutes Ernst3, Chandy C. John1 of Health, Rockville, MD, United States 1University of Minnesota, Minneapolis, MN, United States, 2Moi University, Eldoret, Kenya, 3University of Arizona, Tucson, AZ, United States 198

543 ENDEMIC BURKITT LYMPHOMA IS NOT ASSOCIATED WITH COMMON SINGLE NUCLEOTIDE USING DRIED BLOOD SPOTS TO MONITOR CHANGES POLYMORPHISMS IN TOLL-LIKE RECEPTORS 4 OR 9 IN ANTIBODY LEVELS TO PLASMODIUM FALCIPARUM IN A David H. Mulama REGION OF DECLINING MALARIA TRANSMISSION Kenya Medical Research Institute, Kisumu, Kenya Tamaki Kobayashi1, Sandra Chishimba2, Philip Thuma2, Sungano Mharakurwa2, Nirbhay Kumar1, William J. Moss1 558 1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 2The Malaria Institute at Macha, Choma, Zambia SEROPREVALENCE OF IGG ANTIBODIES TO PLASMODIUM VIVAX MSP-1 ANTIGEN AND PLASMODIUM FALCIPARUM GLURP R2 ANTIGEN IN THE AMAZON AREA, IQUITOS-PERU Katherine Torres1, Elizabeth Villasis1, Jorge Bendezu1, Annette Erhart2, Umberto D’Alessandro2, Dionicia Gamboa1 1Instituto de Medicina Tropical “Alexander von Humboldt”, Universidad Peruana Cayetano Heredia, Lima, Peru, 2Institute of Tropical Medicine “Prince Leopold”, Antwerp, Belgium

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IDENTIFYING B-CELL EPITOPES WITHIN THE LIGAND A DUAL-SPECIFICITY PHOSPHOTYROSINE DOMAIN OF PLASMODIUM VIVAX DUFFY BINDING PHOSPHATASE OF PLASMODIUM FALCIPARUM AND ITS PROTEIN POTENTIAL AS A NOVEL ANTIMALARIAL DRUG TARGET Francis B. Ntumngia Christopher O. Campbell, Bharath Balu, Steven P. Maher, Roman University of South Florida, Tampa, FL, United States Manetsch, John H. Adams University of South Florida, Tampa, FL, United States 91 1082 VALIDATION OF A MULTIPLEX MICROSPHERE-BASED IMMUNOASSAY FOR MEASUREMENT OF ANTI-DENGUE BASOPHILS AND MAST CELLS BECOME VIRUS IMMUNOGLOBULIN ANTIBODIES HYPORESPONSIVE IN CHRONIC HELMINTH Esther M. Volper, Haiyan Olekszak, Bruce Cropp, Janet Meeks, Allison J. INFECTIONS Johnson, Allison Imrie, Duane J. Gubler, Vivek R. Nerurkar David Larson, Marc P. Hübner, Marina N. Torrero, Edward Mitre University of Hawaii, Honolulu, HI, United States Uniformed Services University of the Health Sciences, Bethesda, MD, United States

82 923

APOLIPOPROTEIN E4 STATUS INFLUENCES GROWTH ASYMPTOMATIC MALARIA DETECTION BY PCR AMONG Wednesday, November 18 AND COGNITIVE RESPONSES TO MICRONUTRIENT A COLLATERAL NATIVE POPULATION IN AN ENDEMIC SUPPLEMENTATION IN CHILDREN FROM NORTHEAST REGION AT THE PERUVIAN-ECUADORIAN BORDER BRAZIL Elizabeth Villasis1, Jorge Cacho1, Jorge Bendezu1, Victor Neyra1, Jaime M. Sumeet S. Mitter1, Reinaldo B. Oria2, Michelle P. Kvalsund3, Paula Bernal2, Dionicia Gamboa1 Pamplona2, Rosa M. Mota2, Peter D. Patrick3, Aldo A. Lima2, Richard L. 1Instituto de Medicina Tropical “Alexander Von Humboldt”, Universidad Peruana Guerrant3 Cayetano Heredia, Lima, Peru, 2Lab. Referencial Santa Maria de Nieva, Red de Salud 1David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, Condorcanqui, Amazonas, Amazonas, Peru CA, United States, 2Federal University of Ceara, Fortaleza, Brazil, 3University of Virginia, Charlottesville, VA, United States 943

86 PFMSP3 N-TERMINUS AS A VACCINE TARGET: CROSS-REACTIVE ANTIBODIES IN A HYPOENDEMIC DENGUE VIRUS NONSTRUCTURAL PROTEINS INDUCE TRANSMISSION ENVIRONMENT IL-8 TRANSCRIPTION: ROLE OF VIRAL PROTEINS IN Stephen J. Jordan1, Ana L. Oliveira1, Robert A. Oster1, Oralee H. Branch2, DENGUE IMMUNOPATHOGENESIS Julian C. Rayner3 James F. Kelley, Pakieli Kaufusi, Vivek R. Nerurkar 1University of Alabama at Birmingham, Birmingham, AL, United States, 2New John A. Burns School of Medicine, Honolulu, HI, United States York University, New York, NY, United States, 3Wellcome Trust Sanger Institute, Cambridge, United Kingdom 1094 933 WEST NILE VIRUS GENETIC DIVERSITY AND RNA INTERFERENCE IN THE MOSQUITO CULEX PIPIENS A POTENT MALARIA TRANSMISSION BLOCKING QUINQUEFASCIATUS VACCINE BASED ON CODON-HARMONIZED PFS48/45 1 2 3 1 2 1 Debabani Roy Chowdhury , Evelina Angov , Thomas Kariuki , Nirbhay Doug E. Brackney , Jennifer E. Beane , Gregory D. Ebel 1 1University of New Mexico, Albuquerque, NM, United States, 2Boston University Medical Kumar 1 Center, Boston, MA, United States Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States, 2Walter Reed Army Institute of Research, Silver Spring, MD, United States, 3Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya Young Investigator Award Session E Truman Wednesday, November 18, 11 a.m. - 3:30 p.m.

JUDGES Subash Babu NIH-TRC-ICER, Chennai, India David Williams Rush University Medical Center, Chicago, IL, United States Yimin Wu National Institutes of Health, Rockville, MD, United States

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GLOBAL SEQUENCE VARIATION IN THE HISTIDINE- RETINAL ANGIOGRAPHIC CHANGES IN PAEDIATRIC RICH PROTEIN 2 OF PLASMODIUM FALCIPARUM: CEREBRAL MALARIA IMPLICATIONS FOR PERFORMANCE OF RAPID Simon J. Glover1, Simon P. Harding2, Malcolm E. Molyneux3, Terrie E. DIAGNOSTIC TESTS FOR MALARIA Taylor4, Nicholas A. Beare5 1 2 1 2 2 2 College of Medicine, Blantyre, Malawi, University of Liverpool, Liverpool, United Joanne T. Baker , Michelle Gatton , Mei-Fong Ho , Anita Pelecanos , David 3 3 4 5 6 7 Kingdom, Malawi-Liverpool-Wellcome Trust/College of Medicine, Blantyre, Malawi, Bell , John Barnwell , Jeffery Hii , Bernhards Ogutu , Wellington Oyibo , 4 5 ShanQing Wang8, Jennifer Luchavez9, Christopher Membi10, Lyda Osario11, Blantyre Malaria Project, Blantyre, Malawi, Royal Liverpool University Hospitals Myat Phone Kyaw12, Petra Clowes13, Inge Kroidl13, Dionicia Gamboa14, Trust, Liverpool, United Kingdom Frederic Ariey15, Djibrine Djalle16, Didier Menard17, Marinete Marins Povoa18, Malti Adhin19, Nanhua Chen1, James McCarthy2, Qin Cheng1 135 1Australian Army Malaria Institute, Enoggera, Australia, 2Queensland Institute of Medical Research, Herston, Australia, 3Western Pacifi c Regional Offi ce of the World MALARIAL RETINOPATHY AND MICROCIRCULATION IN Health Organization, Manila, Philippines, 4Centers for Disease Control and Prevention, ADULTS WITH CEREBRAL MALARIA Atlanta, GA, United States, 5Western Pacifi c Regional Offi ce of the World Health 1 2 3 Organization, Solomon Islands, Solomon Islands, 6Centre for Clinical Research, Richard J. Maude , Nicholas A. Beare , Abdullah A. Sayeed , Prakaykaew 1 4 4 4 Kenya Medical Research Institute, Kisumu, Kenya, 7College of Medicine, University of Charunwatthana , M. Abul Faiz , Amir Hossain , Emran B. Yunus , M. 3 3 1 1 Lagos, Odoaraba, Lagos, Nigeria, 8Hainan Provincial Centre for Disease Control and Gofranul Hoque , Mahtab U. Hasan , Nicholas J. White , Nicholas P. Day , 1 Prevention, Haikou, Hainan, China, 9Research Institute for Tropical Medicine, Alabang, Arjen M. Dondorp 1 2 Philippines, 10Bagamoyo/Ifakara Health Research and Development Centre, Ifakara, Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand, St Paul’s Eye 3 United Republic of Tanzania, 11Centro Internacional de Entrenamiento e Investigaciones Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom, Chittagong 4 Medicas, Cali, Colombia, 12Lower Myanmar Department of Medical Research, Yangon, Medical College Hospital, Chittagong, Bangladesh, Malaria Research Group, Myanmar, 13Mbeya Medical Research Programme, Mbeya, United Republic of Tanzania, Chittagong, Bangladesh 14Instituto de Medicina Tropical Alexander Von Humboldt, Peru, Peru, 15Pasteur Institute of Cambodia, Phnom Penh, Cambodia, 16Institut Pasteur de Bangui, Bangui, 345 The Democratic Republic of the Congo, 17Institut Pasteur de Madagascar, Madagascar, Madagascar, 18Evandro Chagas Institute, Belem, Brazil, 19Anton de Kom Universtiteit IMMEDIATE NEUROPSYCHOLOGICAL AND van Suriname, Paramibo, Suriname BEHAVIORAL BENEFITS OF COMPUTERIZED COGNITIVE REHABILITATION IN UGANDAN PEDIATRIC 895 CEREBRAL MALARIA SURVIVORS

1 2 3 4 COMPARISON OF GENOTYPING USING CAPILLARY VS. Paul Bangirana , Bruno Giordani , Chandy C. John , Connie Page , Robert O. Opika1, Michael J. Boivin4 GEL ELECTROPHORESIS FOR TWO ANTIMALARIAL 1Makerere University, Kampala, Uganda, 2University of Michigan, Ann Arbor, MI, DRUG EFFICACY TRIALS IN UGANDA United States, 3University of Minnesota, Minneapolis, MN, United States, 4Michigan Vinay Gupta, Grant Dorsey, Philip Rosenthal, Bryan Greenhouse State University, East Lansing, MI, United States University of California, San Francisco, San Francisco, CA, United States 264 100 ANALYSIS OF STRAIN TRANSMISSION DURING AN WORTH ITS WEIGHT IN GOLD - INTERVENOM - A EPIDEMIC OF MULTI-DRUG RESISTANT TUBERCULOSIS GLOBALLY ACCESSIBLE INTERNET DATABASE TO AMONG AIDS PATIENTS RECEIVING DIRECTLY DOCUMENT AND QUANTIFY THE GLOBAL BURDEN OBSERVED THERAPY SHORT-COURSE (DOTS) OF MORBIDITY AND MORTALITY FROM SNAKE Maria-Graciela Hollm-Delgado1, Fanny Arenas2, Juliana Cordova2, Patricia ENVENOMATION AND TO IMPROVE MANAGEMENT Sheen2, Carlton A. Evans3, Eduardo Ticona4, Robert H. Gilman on behalf of AND OUTCOME TB Collaborative Group5 1Université de Montréal, Montréal, QC, Canada, 2Universidad Peruana Cayetano Alexander Kumar1, Kathy Duong2 Heredia, Lima, Peru, 3Imperial College London, London, United Kingdom, 4Hospital Dos 1Royal Sussex County Hospital, Brighton, United Kingdom, 2Royal Free Hampstead de Mayo, Lima, Peru, 5Johns Hopkins Bloomberg School of Public Health, Baltimore, NHS Trust, London, United Kingdom MD, United States

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WHOLE BLOOD ANGIOPOIETIN-1 AND -2 LEVELS ORGAN SPECIFIC ACCUMULATION AND DISTRIBUTION DISCRIMINATE CEREBRAL AND SEVERE MALARIA OF STRUCTURALLY RELATED ANTI-TRYPANOSOMAL FROM UNCOMPLICATED MALARIA COMPOUNDS: A POSSIBLE ROLE IN RENAL TOXICITY Andrea L. Conroy1, Erin I. Lafferty1, Fiona E. Lovegrove1, Srivicha Rachel Beaulieu Goldsmith, Richard R. Tidwell Krudsood2, Noppadon Tangpukdee2, Sornchai Looareesuwan2, W. Conrad University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Liles3, Kevin C. Kain3 1McLauglin-Rotman Centre for Global Health, University of Toronto, Toronto, ON, Canada, 2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 492 3Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, ON, Canada AN UNUSUAL HSP70 PRESENT IN RARE LEISHMANIA VIANNIA ISOLATES FROM PERU Nicolas Veland1, Rosa Pacheco2, Jorge Arevalo1 1Universidad Peruana Cayetano Heredia, Lima, Peru, 2Universidad Nacional San Antonio Abad, Cusco, Peru

54 ASTMH 58th Annual Meeting www.astmh.org

713 ACMCIP Council Meeting

IDENTIFICATION OF COLONIZATION FACTOR Capitol Boardroom ANTIGEN IN NON-ENTEROTOXIGENIC E. COLI STRAINS Wednesday, November 18, 3:30 p.m. - 5:30 p.m. Fulton P. Rivera1, Maria Bernal2, Theresa J. Ochoa1, Rina Meza2, Francesca ACME Council Meeting Barletta1, Erik Mercado1, Maribel Riveros1, David Cepeda2, Ryan C. Maves2, Eric R. Hall3, Ann-Mari Svennerholm4, Claudio F. Lanata5 Room 8217 1 2 Universidad Peruana Cayetano Heredia, Lima, Peru, United States Naval Medical Wednesday, November 18, 3:30 p.m. - 5:30 p.m. Research Center Detachment, Lima, Peru, 3United States Naval Medical Research Center, Silver Spring, MD, United States, 4Göteburg University, Göteburg, Sweden, Clinical Group Council Meeting 5Instituto de Investigacion Nutricional, Lima, Peru Room 8218 1145 Wednesday, November 18, 3:30 p.m. - 5:30 p.m.

HIGH THROUGHPUT GENE EXPRESSION PROFILING OF Young Investigator Award Committee Meeting SALMONELLA ENTERICA SEROVAR PARATYPHI A IN THE Jackson BLOOD OF BACTEREMIC PATIENTS IN BANGLADESH Wednesday, November 18, 3:30 p.m. - 5 p.m. Richelle C. Charles1, Alaullah Sheikh2, Sean Rollins1, Jason B. Harris1, Md. Saruar Bhuiyan2, Farhana Khanam2, Archana Bukka3, Anuj Kalsy1, Steffen Student Reception Porwollik4, W. Abdullah Brooks2, Regina LaRocque1, Michael McClelland4, Tanya Logvinenko5, Alejandro Cravioto2, Stephen B. Calderwood1, James E. Exhibit Hall B South Wednesday, November 18 Graham3, Firdausi Qadri2, Edward T. Ryan1 Wednesday, November 18, 4 p.m. - 5 p.m. 1Massachusetts General Hospital, Boston, MA, United States, 2International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, 3University of Louisville, The ASTMH council invites students, postdoctoral fellows and residents to Louisville, KY, United States, 4Sidney Kimmel Cancer Center, San Diego, CA, United the student reception. This reception is an opportunity to meet fellow trainees States, 5Tufts University Medical Center, Boston, MA, United States and interact with society leaders.

34 Plenary Session 1 INHIBITION OF DOWNSTREAM MEDIATORS OF THE TYPE I INTERFERON RESPONSE IN DENGUE VIRUS Opening Plenary Session and Awards Ceremony INFECTED MONOCYTE-DERIVED DENDRITIC CELLS Salon 123 AND BYSTANDER T CELL ACTIVATION Wednesday, November 18, 5:30 p.m. - 7:30 p.m. Amanda J. Chase, Freddy A. Medina, Jorge L. Muñoz-Jordán Dengue Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control CHAIR and Prevention, San Juan, PR, United States Thomas E. Wellems ASTMH President, Rockville, MD, United States Cyber Cafe Christopher L. King Case Western Reserve University, Cleveland, OH, United States Marriott Foyer Wednesday, November 18, Noon - 6 p.m. 5:45 p.m. Speaker Ready Room Human Aspects of Scientifi c Discovery Peter Agre Maryland A Johns Hopkins University, Baltimore, MD, United States Wednesday, November 18, Noon - 6 p.m. 6:15 p.m. ACAV SIRACA Subcommittee Meeting AWARDS CEREMONY Room 8219 RICHARD M. TAYLOR AWARD Wednesday, November 18, Noon - 2 p.m. Announced by Charles Calisher Colorado State University, Fort Collins, CO, United States ASTMH Global Health Working Group Meeting COMMUNICATIONS AWARD Balcony C Vivienne Walt Time Magazine, Paris, France Wednesday, November 18, Noon - 2 p.m. Presented by Claire Panosian ACAV SALS Subcommittee Meeting UCLA School of Medicine, Los Angeles, CA, United States HONORARY MEMBERS Room 8219 Brian Greenwood Wednesday, November 18, 2 p.m. - 3:30 p.m. London School of Hygiene and Tropical Medicine, London, United Kingdom Ralph Lainson ACAV Council Meeting Instituto Evandro Chagas, Belem, Brazil Presented by Thomas P. Monath Room 8219 Kleiner Perkins Caulfi ield & Byers, Harvard, MA, United States Wednesday, November 18, 3:30 p.m. - 5:30 p.m.

55 www.astmh.org Detailed Program

HARRY HOOGSTRAAL MEDAL Symposium 2 William Collins Centers for Disease Control and Prevention, Atlanta, GA, United States Presented by Stephen Higgs Global Health Cornerstone Symposium I University of Texas Medical Branch, Galveston, TX, United States Salon 2 BAILEY K. ASHFORD MEDAL Thursday, November 19, 8 a.m. - 9:45 a.m. Jesus Valenzuela National Institutes of Health, Rockville, MD, United States This session serves as a cornerstone to a range of symposia focusing on the Presented by Jose Ribeiro topic of global health. This year marks the fi rst ASTMH conference that National Institutes of Health, Rockville, MD, United States features a formal series of symposia centered around globalization’s impact DONALD MACKAY MEDAL on health, health disparities and global health partnerships. In this session, Jane Cardosa epidemiological transition will be discussed as it relates to global health. In University Malaysia Sarawak, Kota Samarahan, Malaysia addition, the economics of the recent rapid growth of development assistance Presented by Nikos Vasilakis for global health to low-income and middle-income countries will be explored University of Texas Medical Branch, Galveston, TX, United States during this session. A lively question and answer period is anticipated JOSEPH AUGUSTIN LePRINCE MEDAL following the presenter’s remarks. Wilbur K. Milhous University of South Florida, Tampa, FL, United States CHAIR Presented by Stephen L. Hoffman Michele Barry Sanaria, Inc., Rockville, MD, United States Stanford University, Stanford, CA, United States Claire Panosian Opening Reception University of California at Los Angeles School of Medicine, Los Angeles, CA, United States Exhibit Hall A Wednesday, November 18, 7:30 p.m. - 9:30 p.m. 8 a.m. Exhibit Hall Open INTRODUCTION Michele Barry Exhibit Hall A Stanford University, Stanford, CA, United States Wednesday, November 18, 7:30 p.m. - 9:30 p.m. 8:15 a.m. Thursday, November 19 FROM TROPICAL DISEASE TO HEALTH IN THE TROPICS: A PERSPECTIVE FROM ECONOMICS Registration Dean Jamison University of Washington, Seattle, WA, United States Salon Foyer 9:05 a.m. Thursday, November 19, 7 a.m. - 5 p.m. QUESTION AND ANSWER PERIOD Cyber Cafe 9:20 a.m. Marriott Foyer Thursday, November 19, 7 a.m. - 5 p.m. GLOBAL HEALTH WORKING GROUP BUSINESS MEETING Speaker Ready Room Michele Barry Maryland A Stanford University, Stanford, CA, United States Thursday, November 19, 7 a.m. - 6 p.m. Symposium 3 ASTMH Diploma Course Directors Meeting Diagnostic Tests for Visceral Leishmaniasis: Room 8212 The Next Generation Thursday, November 19, 7 a.m. - 8 a.m. Clinical Group Education Curriculum Meeting Delaware A Thursday, November 19, 8 a.m. - 9:45 a.m. Room 8217 Thursday, November 19, 7 a.m. - 8 a.m. The current generation of diagnostic tests for visceral leishmaniasis (VL) has signifi cantly improved our ability to make a point of care diagnosis in Public Policy and Advocacy Leadership Committee Meeting the ill patient. However, the next generation of tests needs to have improved worldwide diagnostic sensitivity, allow for prognostic information, drug Room 8211 resistance prediction, predict test of cure and assess for transmission potential. Thursday, November 19, 7 a.m. - 8 a.m. This symposium will focus on 1) assessing the state of the art – from LD bodies to rk39, 2) identifying the needs in the fi eld and the indications for the Media Room next generation of VL diagnostic tests, 3) Basic science approaches to new antigen discovery and qualifi cation, and 4) new or novel platform technologies Rooms 8228/8229 to translate best science from the bench to the bedside. Thursday, November 19, 7:30 a.m. - 6:30 p.m.

56 ASTMH 58th Annual Meeting www.astmh.org

CHAIR CHAIR Alan Magill Robert Massung Walter Reed Army Institute of Research, Silver Spring, MD, United States Centers for Disease Control and Prevention, Atlanta, GA, United States Ajay Bhatia IDRI, Seattle, WA, United States 8 a.m. Q FEVER: ANOTHER GREAT IMITATOR 8 a.m. Michael W. Ellis VL DIAGNOSTIC TESTS: FROM LD BODIES TO RK39 Uniformed Services University of the Health Sciences, Bethesda, MD, United States Shyam Sundar Banaras Hindu University, Varanasi, India 8:25 a.m. THE “R”S OF Q FEVER EPIDEMIOLOGY: RISKS, RATES, 8:25 a.m. AND RECONNAISSANCE VL DIAGNOSTIC TESTS: THE NEXT GENERATION Alicia D. Anderson Alan Magill Centers for Disease Control and Prevention, Atlanta, GA, United States Walter Reed Army Institute of Research, Silver Spring, MD, United States 8:50 a.m. 8:50 a.m. CLINICAL LABORATORY METHODS AND TESTING NEW ANTIGEN DISCOVERY APPROACHES FOR VL STRATEGY FOR ACUTE AND CHRONIC Q FEVER Ajay Bhatia William L. Nicholson IDRI, Seattle, WA, United States Centers for Disease Control and Prevention, Atlanta, GA, United States 9:15 a.m. 9:15 a.m. NOVEL ISOTHERMAL AMPLIFICATION METHODS FOR ISSUES REGARDING LONG-TERM FOLLOW-UP AND THE DIAGNOSIS OF LEISHMANIASIS PREVENTION OF ENDOCARDITIS FOLLOWING ACUTE Emily R. Adams Q FEVER Royal Tropical Institute (KIT), Amsterdam, The Netherlands Todd D. Gleeson National Naval Medical Center, Bethesda, MD, United States Symposium 4 Scientifi c Session 5

The Evolution of Q Fever: Updates on Recent Changes Thursday, November 19 in Epidemiology, Diagnosis, Clinical Manifestations, Malaria - Drug Resistance Treatment, and Follow-Up Virginia AB Delaware B Thursday, November 19, 8 a.m. - 9:45 a.m. Thursday, November 19, 8 a.m. - 9:45 a.m. CHAIR Q fever, caused by Coxiella burnetii, is an acute febrile illness with worldwide Nanhua Chen distribution. The disease, once considered a hazard of certain occupations and Australian Army Malaria Institute, Brisbane, Australia endemic only in specifi c geographic areas, has had a resurgence in the past Richard Eastman several years. The number of reported cases has been increasing in the U.S. Columbia University, New York, NY, United States population and in returning travelers with appropriate exposure histories. A signifi cant number of cases have been associated with military confl icts, 8 a.m. including in U.S. troops deployed to Iraq and Afghanistan. In addition to an increasing number of reported cases, there have been multiple atypical 1 presentations, resulting in delayed diagnosis and initiation of therapy. The disease is typically diagnosed clinically and then confi rmed with serology; ALTERATIONS IN PLASMODIUM FALCIPARUM GENETIC however, investigative polymerase chain reaction (PCR) assays are being STRUCTURE AFTER INCREASED MALARIA CONTROL employed in some settings. Serologic testing, while commercially available, is not necessarily standardized and can have signifi cant inter-and intra- EFFORTS IN TWO DISTRICTS OF WESTERN KENYA laboratory variation. Chronic disease (specifi cally endocarditis) can occur Anne M. Vardo-Zalik, Daibin Zhong, Guiyun Yan after acute infection and recent studies have attempted to identify patients University of California at Irvine, Irvine, CA, United States who are at risk for persistent infection. Minor valvulopathy is reported to be a risk factor for chronic infection, and some researchers have recommended prophylactic therapy (12 months of doxycycline and hydroxychloroquine) in these patients in order to prevent endocarditis. Some researchers also recommend periodic serological testing and screening for endocarditis if Phase I IgG titers rise above 1:800. These recommendations are largely based on one institution and their applicability to other patient populations (younger and healthier) remains to be defi ned. The goal of this symposium is to review the epidemiology, diagnosis, treatment and areas of uncertainty related to Q fever.

57 www.astmh.org Detailed Program

8:15 a.m. 9:15 a.m.

2 6

MULTIPLE GENETIC BACKGROUNDS OF THE FREQUENT CHROMOSOMAL REARRANGEMENT IN AMPLIFIED PLASMODIUM FALCIPARUM MULTIDRUG PLASMODIUM FALCIPARUM RESISTANT TO ARTELINIC RESISTANCE (PFMDR1) GENE AND SELECTIVE SWEEP ACID IN VITRO OF 184F MUTATION IN CAMBODIA Nanhua Chen1, Marina Chavchich1, Michelle Gatton2, Dennis E. Kyle3, Qin Sumiti Vinayak1, Md Tauqeer Alam2, Rithy Sem3, Naman K. Shah4, Cheng1 Augustina I. Susanti5, Pharath Lim6, Sinuon Muth3, Jason D. Maguire5, 1Australian Army Malaria Institute, Brisbane, Australia, 2Queensland Institute of William O. Rogers5, Thierry Fandeur7, John W. Barnwell2, Ananias A. Medical Research, Brisbane, Australia, 3University of South Florida, Tampa, FL, United Escalante8, Chansuda Wongsrichanalai5, Frederick Ariey6, Steven R. States Meshnick4, Venkatachalam Udhayakumar2 1Atlanta Research and Education Foundation and Malaria Branch, Division of Parasitic 9:30 a.m. Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, 7 United States, 2Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, LARGE GENETIC POLYMORPHISM OF THE PLASMODIUM Centers for Disease Control and Prevention, Atlanta, GA, United States, 3National FALCIPARUM NA+/H+ EXCHANGER (PFNHE-1) AND ITS Malaria Center, Phnom Penh, Cambodia, 4Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC, United States, 5United States ASSOCIATION WITH QUININE RESISTANCE Naval Medical Research Unit No. 2, Jakarta, Indonesia, 6Institut Pasteur in Cambodia, Stéphane Pelleau1, Lionel Bertaux1, Sébastien Briolant1, Michael T. Ferdig2, Phnom Penh, Cambodia, 7Institut Pasteur, Unité d’Immunologie Moléculaire des Véronique Sinou3, Bruno Pradines1, Jacques Lebras4, Frédéric Ariey5, Daniel Parasites, Paris, France, 8School of Life Sciences, Arizona State University, Tempe, AZ, Parzy1, Ronan Jambou6 United States 1Institut de Médecine Tropicale du Service de Santé des Armées, Marseille, France, 2University of Notre Dame, Notre Dame, IL, United States, 3Université de la 8:30 a.m. Méditerranée, Marseille, France, 4Université Paris Descartes, Paris, France, 5Institut Pasteur du Cambodge, Phnom Penh, Cambodia, 6Institut Pasteur, Paris, France 3 (ACMCIP Abstract)

COPY NUMBER VARIATION AND POINT MUTATIONS IN Scientifi c Session 6 PFMDR1 IN PLASMODIUM FALCIPARUM ISOLATES FROM VENEZUELA Ectoparasite-Borne Diseases Tonya Mixson-Hayden1, Sean Griffi ng1, Luke Syphard1, Sankar Sridaran1, Andrea McCollum1, Sumiti Vinayak1, Leopoldo Villegas2, John Barnwell1, Virginia C Ananias A. Escalante3, Venkatachalam Udhayakumar1 Thursday, November 19, 8 a.m. - 9:45 a.m. 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Asociación Civil Impacto Social, Tumeremo, Venezuela, 3Arizona State University, Tempe, AZ, CHAIR United States Jennifer M. Anderson National Institutes of Health, Rockville, MD, United States 8:45 a.m. Yvette Girard University of California - Berkeley, Berkeley, CA, United States 4 8 a.m. SULFADOXINE-PYRIMETHAMINE, SULFADOXINE- PYRIMETHAMINE + ARTESUNATE, AND AL FOR 8 UNCOMPLICATED MALARIA INFECTION IN TANZANIA FROM 2004 TO 2006 ROLE OF ELEVATED TRANSCRIPTION OF Julie R. Gutman1, Abdunoor Mulokozi2, Deborah Sumari2, Allan Malisa2, GLUTATHIONE S-TRANSFERASES (GSTS) IN Peter B. Bloland3, S. Patrick Kachur3, Salim Abdulla2, John R. MacArthur3 PYRETHROID RESISTANT SCABIES MITES 1 Centers for Disease Control and Prevention and Emory University, Atlanta, GA, United 1 1 2 2 2 Cielo Pasay , Kate Mounsey , Larry Arlian , Marjorie Morgan , Deborah States, Ifakara Health Research and Development Centre, Dar-es-Salaam, United 3 4 3 1 3 Holt , Bart Currie , Shelley Walton , James McCarthy Republic of Tanzania, Centers for Disease Control and Prevention, Atlanta, GA, United 1Queensland Institute of Medical Research, Brisbane, QLD, Australia, 2Wright State States University, Dayton, OH, United States, 3Menzies School of Health Research, Darwin, Northern Territory, Australia, 4Flinders University, Darwin, Northern Territory, 9 a.m. Australia 5

IN VITRO SELECTION OF PIPERAQUINE RESISTANT PLASMODIUM FALCIPARUM Richard T. Eastman1, Neekesh V. Dharia2, Elizabeth A. Winzeler2, David A. Fidock1 1Columbia University, New York, NY, United States, 2The Scripps Research Institute, La Jolla, CA, United States

58 ASTMH 58th Annual Meeting www.astmh.org

8:15 a.m. Symposium 7 9 Newly Described Mosquito-Specifi c Flaviviruses: UNIQUE POPULATION STRUCTURE OF BORRELIA Geographic Distribution, Genetic Relatedness and Potential BURGDORFERI IN THE WESTERN BLACK-LEGGED TICK Role for Augmentation of Heterologous Infections (IXODES PACIFICUS) IN NORTHERN CALIFORNIA Washington 1 1 2 3 Yvette A. Girard , Bridgit Travinsky , Anna Schotthoefer , Natalia Thursday, November 19, 8 a.m. - 9:45 a.m. Fedorova1, Rebecca J. Eisen3, Lars Eisen4, Alan G. Barbour2, Robert S. Lane1 1 2 University of California - Berkeley, Berkeley, CA, United States, University of Cell fusing agent virus (CFAV) was discovered in an Aedes aegypti cell line in 3 California - Irvine, Irvine, CA, United States, Centers for Disease Control and the mid 1970s and for decades remained the sole known representative in a Prevention, Fort Collins, CO, United States, 4Colorado State University, Fort Collins, novel lineage of mosquito-specifi c fl aviviruses within the family Flaviviridae. CO, United States More than 25 years later, a similar mosquito-specifi c fl avivirus, Kamiti River 8:30 a.m. virus (KRV), was isolated from Aedes macintoshi mosquitoes in Kenya. Within the last few years, the study of mosquito-specifi c fl aviviruses has exploded, with the discovery and characterization of numerous virus isolates related 10 to CFAV and KRV from a diversity of culicine mosquito species around the world. This cosmopolitan clade of newly-recognized viruses has prompted PREDICTED EFFECTS OF HOST RESERVOIR-TARGETED many questions regarding the evolution of vector-borne fl aviviruses, as well VACCINATION ON LYME DISEASE RISK as the natural history and potential impact of mosquito-specifi c fl aviviruses Kimberly Tsao, Durland Fish, Alison Galvani on the transmission effi ciency of arboviruses of public health importance. Yale University, New Haven, CT, United States Topics that will be discussed in this symposium include the discovery, growth, transmission mechanisms, geographic distribution and prevalence, genetic 8:45 a.m. diversity, and host range of mosquito-specifi c fl aviviruses, including KRV and western hemispheric Culex fl aviviruses (CxFV) isolated from Canada 11 to Guatemala. The potential for these viruses to modulate the transmission of West Nile virus will also be addressed. A closing discussion among the TICK BORNE RELAPSING FEVER IN MALI presenters and audience regarding research fi ndings to date and future research directions for this fi eld will be invited. Jennifer M. Anderson1, Job Lopez2, Nafomon Sogoba3, Merry E. Schrumpf2, Sandra J. Raffel2, Tom G. Schwan2 CHAIR 1National Institutes of Health, Rockville, MD, United States, 2National Institutes 3 Rebekah J. Kent of Health, Hamilton, MT, United States, Malaria Research and Training Center, Thursday, November 19 Bamako, Mali Centers for Disease Control and Prevention, Fort Collins, CO, United States Aaron Brault 9 a.m. Centers for Disease Control and Prevention, Fort Collins, CO, United States

12 8 a.m. HOW A CHANCE OBSERVATION LED TO THE REDUCED GENE FLOW BETWEEN DOG TICK DEMES DISCOVERY AND FIRST DESCRIPTION OF A MOSQUITO ON MARTHA’S VINEYARD AS A BASIS FOR INSULAR FLAVIVIRUS METAPOPULATION STRUCTURE OF FRANCISELLA Victor Stollar TULARENSIS Robert Wood Johnson Medical School, Piscataway, NJ, United States Heidi K. Goethert1, Benjamin M. Rosenthal2, Sam R. Telford, III1 1Tufts University School of Veterinary Medicine, N. Grafton, MA, United States, 2United 8:25 a.m. States Department of Agriculture, Beltsville, MD, United States DISTRIBUTION AND GENETIC RELATEDNESS OF 9:15 a.m. MOSQUITO-SPECIFIC FLAVIVIRUSES: FROM CANADA TO CALIFORNIA 13 Michael Drebot National Microbiology Laboratory, Winnipeg, MB, Canada RICKETTSIA RICKETTSII IN LONE STAR TICKS FROM KANSAS 8:50 a.m. Zenda L. Berrada, Sam R. Telford, III DYNAMICS OF AN INSECT-ONLY FLAVIVIRUS IN A Tufts Cummings School of Veterinary Medicine, North Grafton, MA, United States NATURALLY INFECTED MOSQUITO COLONY Bethany Bolling 9:30 a.m. Colorado State University, Fort Collins, CO, United States 14 9:15 a.m. CHARACTERIZATION OF KAMITI RIVER VIRUS AND IMPROVEMENT OF SEROLOGICAL ASSAYS FOR CULEX FLAVIVIRUS (CXFV) IZABAL STRAIN INFECTION RICKETTSIAL AND RICKETTSIAL RELATED DISEASES IN MOSQUITOES, AND EFFECT OF CXFV INFECTION ON BY RECOMBINANT ANTIGENS VECTOR COMPETENCE FOR WEST NILE VIRUS Wei-Mei Ching, Hua-Wei Chen, Chien-Chung Chao, Erin Huber, Erin G. Glennon, Margarita T. Esteban, Zhiwen Zhang Rebekah J. Kent Naval Medical Research Center, Silver Spring, MD, United States Centers for Disease Control and Prevention, Fort Collins, CO, United States

59 www.astmh.org Detailed Program

Symposium 8 success to the rest of country to achieve transmission control at the same year. However, public health authorities in China have recognized challenges facing them in trying to achieve this goal. For example, there is a growing concern ACMCIP (American Committee of Molecular, Cellular about re-emergence of schistosomiasis in areas where transmission control and Immunoparasitology) Symposium: “Express Yourself”: was previously achieved. In parallel with these control activities has been Strategies Used By Parasites to Regulate Genes tremendous research work covering a wide range of areas by both domestic and international researchers. Research activities have evolved with an Supported with funding from The Burroughs increasing understanding of the disease and control stages. The presentations Wellcome Fund in this session are based on previous and ongoing research and control work, and will share experiences and lessons learned from the work in China.

Washington 2 CHAIR Thursday, November 19, 8 a.m. - 9:45 a.m. Xiao-nong Zhou National Institute of Parasitic Disease, Chinese Center for Disease Control and Parasites use a variety of strategies to regulate genes. This symposium will Prevention, Shanghai, China explore some of the mechanisms employed by parasites to govern gene expression, such as regulating transcription and post-transcriptional processes. Song Liang The Ohio State University, Columbus, OH, United States CHAIR 8 a.m. Sarah K. Volkman Harvard School of Public Health, Boston, MA, United States ELIMINATING TRANSMISSION OF SCHISTOSOMA JAPONICUM Rick Fairhurst IN CHINA – OPPORTUNITY, CHALLENGES, National Institutes of Health, Bethesda, MD, United States AND FIELD EXPERIENCES Xiao-nong Zhou 8 a.m. National Institute of Parasitic Disease, Chinese Center for Disease Control and EXPLORING TRANSCRIPTIONAL REGULATION IN Prevention, Shanghai, China PLASMODIUM FALCIPARUM 8:30 a.m. Manuel Llinas Princeton University, Princeton, NJ, United States EPIDEMIOLOGIC EVIDENCE AND MODELING OF HYDROLOGIC AND SOCIAL FACTORS ASSOCIATED 8:35 a.m. WITH SUSTAINED SCHISTOSOMA JAPONICUM INFECTION DEEP SEQUENCING OF SMALL AND LARGE Edmund Seto TRANSCRIPTS REVEALS NOVEL ASPECTS OF RNA University of California at Berkeley, Berkeley, CA, United States BIOLOGY IN TRYPANOSOMA BRUCEI 8:55 a.m. Elisabetta Ullu Yale University, New Haven, CT, United States UNDERSTANDING SCHISTOSOME SPREAD: ANALYTICAL METHODS FOR QUANTIFYING THE ROLE 9:10 a.m. OF ENVIRONMENTAL PHENOMENA IN THE SPREAD GENE REGULATION IN ENTAMOEBA HISTOLYTICA AND CONTROL OF S. JAPONICUM Upinder Singh Justin Remais Stanford University, Palo Alto, CA, United States Emory University, Atlanta, GA, United States 9:20 a.m. Symposium 9 LINKING REMOTE SENSING AND SCHISTOSOMIASIS Eliminating Transmission of Schistosoma japonicum in TRANSMISSION USING BAYESIAN SPATIAL STATISTICS IN CHINA China: Opportunities and Challenges Guo-Jing Yang Washington 3 Jiangsu Institute of Parasitic Diseases, Wuxi, China Thursday, November 19, 8 a.m. - 9:45 a.m. Scientifi c Session 10 The past decades have witnessed China’s overall success in combating schistosomiasis. In the 1950s, over 10 million people were infected in 12 Mosquitoes - Vector Biology - Epidemiology I provinces. A national control program was instituted in the 1950s and a cascade of control activities followed, resulting in a reduction of human cases Washington 4 to less than one 1 million in the early 2000s and transmission elimination in Thursday, November 19, 8 a.m. - 9:45 a.m. fi ve provinces. The extensive control programs were suspended in the early 2000s until the outbreak of SARS in China prompted the government to CHAIR launch a broad-scale campaign against major infectious diseases, including schistosomiasis. Control efforts toward schistosomiasis have been beefed Theodore G. Andreadis The Connecticut Agricultural Experiment Station, New Haven, CT, United States up since then and further fueled by the passage of unprecedented Statute of Schistosomiasis Control by the State of Department of China in 2005. Peter Armbruster The implementation of such integrated programs has yielded great reward Georgetown University, Washington, DC, United States – transmission control of S. japonicum has been widely achieved in Sichuan province in 2008, marking a milestone in the history of schistosomiasis control in China. An ambitious proposal has been laid out – to eliminate transmission of the parasite in Sichuan and Yunnan provinces by 2015, and to expand the

60 ASTMH 58th Annual Meeting www.astmh.org

8 a.m. 9:15 a.m.

15 20

MOLECULAR PHYSIOLOGY OF THE DIAPAUSE ANTHROPOPHILY OF SERGENTOMYIA SPECIES IN A PROGRAM IN THE ASIAN TIGER MOSQUITO, AEDES LEISHMANIASIS OUTBREAK AREA IN THE HO DISTRICT ALBOPICTUS OF GHANA Peter Armbruster1, Jennifer Urbanski1, M. Robert Michaud2, Joshua Kwame Desewu1, Shirley C. Odoom1, Naiki Puplampu1, Greg Raczniak2, Benoit2, David L. Denlinger2 Karl Kronmann2, Millicent Cobblah3, Maxwell Appawu1, Michael D. Wilson1, 1Georgetown University, Washington, DC, United States, 2The Ohio State University, Daniel A. Boakye1 Columbus, OH, United States 1Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana, 2United States NAMRU 3/Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana, 8:15 a.m. 3Department of Zoology, University of Ghana, Legon, Accra, Ghana

16 9:30 a.m.

EVIDENCE FOR COMPETITIVE REDUCTION OF NATIVE 21 MOSQUITOES IN THE NORTHEASTERN UNITED STATES BY THE INVASIVE EXOTIC SPECIES, OCHLEROTATUS IDENTIFICATION OF A NATURAL POPULATION OF JAPONICUS JAPONICUS (DIPTERA: CULICIDAE) HYBRIDS BETWEEN TAXONOMIC GROUPS OF TRIATOMA DIMIDIATA IN THE YUCATAN PENINSULA, MEXICO, AND Theodore G. Andreadis1, Roger J. Wolfe2 1The Connecticut Agricultural Experiment Station, New Haven, CT, United States, ITS EPIDEMIOLOGICAL IMPORTANCE 2Connecticut Department of Environmental Protection, North Franklin, CT, United Melba Herrera-Aguilar1, Leobardo Be-Barragan1, Maria Jesus Ramirez- States Sierra1, Frederic Tripet2, Patricia Dorn3, Eric Dumonteil4 1Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico, 2Keele University, 8:30 a.m. Newcastle, United Kingdom, 3Loyola University New Orleans, New Orleans, LA, United States, 4Tulane University, New Orleans, LA, United States 17 Symposium 11 VARIATIONS IN RESTING PATTERNS OF AEDES AEGYPTI IN RESPONSE TO MATERIAL TEXTURE AND COLOR National Institutes of Health and Tropical Medicine: USING EXPERIMENTAL HUTS Supporting International Research and Career Thursday, November 19 Krajana Tainchum1, Suppaluck Polsomboon1, Sungsit Sungvornyothin2, Development - Part I Wannapa Suwonkerd3, Nicole Achee4, John Grieco4, Theeraphap Chareonviriyaphap1 Washington 5 1Kasetsart University, Bangkok, Thailand, 2Mahidol University, Bangkok, Thailand, Thursday, November 19, 8 a.m. - 9:45 a.m. 3Offi ce of Disease Prevention and Control No.10, Ministry of Public Health, Chiang Mai, Thailand, 4Department of Preventive Medicine and Biometrics, Uniformed Services This symposium, organized by the ASTMH Education Committee in University of the Health Sciences, Bethesda, MD, United States collaboration with the National Institutes of Health, is designed to educate 8:45 a.m. young investigators, including graduate students, post-doctoral fellows, MD/ PhD students, clinicians interested in research and others in the structure of 18 NIH, the review process and grantsmanship in order to maximize the chances of obtaining competitive funding.

UNEXPECTED ANTHROPOPHILY IN THE POTENTIAL CHAIR MALARIA VECTORS ANOPHELES COUSTANI AND Stephen Higgs ANOPHELES SQUAMOSUS IN MACHA, ZAMBIA University of Texas Medical Branch, Galveston, TX, United States 1 1 2 Laura C. Norris , Christen M. Fornadel , Shadreck Habbanti , Mulenga Adriana Costero 2 1 1 Musapa , Jessica Hollingsworth , Douglas E. Norris National Institutes of Health, Bethesda, MD, United States 1Johns Hopkins School of Public Health, Baltimore, MD, United States, 2Malaria Institute at Macha, Macha, Zambia 8 a.m. 9 a.m. PUBLIC AND SCIENTIFIC ACCOUNTABILITY: HOW WILL YOU MEASURE UP IN THE FUTURE? 19 John J. McGowan National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States ANALYSIS OF ANOPHELES ARABIENSIS BLOOD FEEDING BEHAVIOR IN SOUTHERN ZAMBIA DURING THE 8:25 a.m. TWO YEARS FOLLOWING THE INTRODUCTION OF REFLECTIONS ON NATIONAL INSTITUTE OF ALLERGY INSECTICIDE TREATED BED NETS AND INFECTIOUS DISEASES AND THE HISTORY OF Christen M. Fornadel1, Shadreck Habbanti2, Laura C. Norris1, Douglas E. TROPICAL MEDICINE 1 Norris David M. Morens 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States 2Malaria Institute at Macha, Choma, Zambia

61 www.astmh.org Detailed Program

8:50 a.m. 8:55 a.m. NATIONAL INSTITUTES OF HEALTH RESEARCH GENOME ANALYSIS OF THE RICKETTSIAL OPPORTUNITIES AND PRIORITIES FOR HIV- ENDOSYMBIONT FROM IXODES SCAPULARIS: GENOME ASSOCIATED CO-INFECTIONS EXPANSION VIA EXTREME TRANSPOSITION AND A Robert W. Eisinger PROLIFERATED CONJUGATION SYSTEM National Institutes of Health, Bethesda, MD, United States Joseph Gillespie Virginia Bioinformatics Institute, Blacksburg, VA, United States 9:15 a.m. IDENTIFYING RESEARCH FUNDING OPPORTUNITIES 9:20 a.m. Patricia Haggerty IXODES POPULATION GENETICS AND EVOLUTIONARY National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States GENOMICS OF TICK-MICROBE INTERACTIONS Joyce Sakamoto Symposium 12 Institute for Genome Sciences, Baltimore, MD, United States

The Ixodes Genome Project and Advances in Tick Genome Exhibit Hall Open Research Exhibit Hall A Wilson AB Thursday, November 19, 9:30 a.m. - 10:30 a.m. Thursday, November 19, 8 a.m. - 9:45 a.m. Coffee Break Ticks in the family Ixodidae (hard ticks) transmit the greatest variety of pathogens of any invertebrate vector and are second only to mosquitoes as Exhibit Hall A vectors of human disease. In the U.S., the Lyme disease tick, Ixodes scapularis, Thursday, November 19, 9:45 a.m. - 10:15 a.m. transmits the causative agents of Lyme disease, babesiosis, and human Supported with funding from SCYNEXIS, Inc. granulocytic anaplasmosis. The I. scapularis genome was recently sequenced to 3.8 fold coverage with funding from the National Institutes of Health (NIH). Poster Session A Set-Up This project is the fi rst to sequence a medically signifi cant tick species and a member of the subphylum Chelicerata. Genome data are proving a powerful Exhibit Hall B South resource for tick-borne-disease research and comparative evolutionary Thursday, November 19, 9:45 a.m. - 10:15 a.m. analyses. The goals of this symposium are two-fold, namely a) to publicize this landmark achievement to the broader scientifi c research community, and Poster Session A Viewing b) showcase some of the exciting new scientifi c advances made possible by this project. Many of these advances are helping scientists to address age-old Exhibit Hall B South questions in tick research and may ultimately lead to new approaches for Thursday, November 19, 10:15 a.m. - Noon control of tick-borne diseases. This symposium will highlight several research areas spawned by the I. scapularis genome project, including studies of genome organization and evolution, chromosome biology and population genetics. The Symposium 13 genome of a rickettsial endosymbiont from I. scapularis was also assembled as part of the tick genome project. The symposium will feature comparative The Global Financial Crisis and Global Health genome studies that suggest that this endosymbiont is a member of a novel sub-group within the genus Rickettsia. This event is timely as it is expected Salon 2 to coincide with the publication of multiple genome manuscripts. It will also Thursday, November 19, 10:15 a.m. - Noon set the stage for strategic planning efforts to generate recommendations for additional community driven tick genome sequencing initiatives. This The speakers will present their analyses of the impact that the downturn in symposium is expected to have broad appeal to scientists interested in ticks, the world economy is having on health programs worldwide, specifi cally on tick-borne diseases and tick-endosymbiont interactions. the control of malaria, HIV, TB and childhood vaccination. One presenter will explain the approach of the Gates Foundation to possible reduction in CHAIR funds available for the malaria programs it supports. Impacts are expected on Catherine A. Hill child survival, vaccine production and research on new drugs and vaccines, Purdue University, West Lafayette, IN, United States and health program support to needy countries. Projections of morbidity and mortality for the next decades will have to be revised. These effects will Vishvanath Nene be set against possible positive results on health of the downturn, such as International Livestock Research Institute, Nairobi, Kenya reduction in atmospheric pollution due to reduced industrial and motor vehicle 8 a.m. emissions. ASSEMBLY AND ANNOTATION OF THE GENOME OF CHAIR THE LYME DISEASE TICK, IXODES SCAPULARIS Jack Woodall Ewen Kirkness Federal University of Rio de Janeiro, Rio de Janeiro, Brazil J. Craig Venter Institute, Rockville, MD, United States 10:15 a.m. 8:30 a.m. THE IMPACT OF THE GLOBAL ECONOMIC CRISIS ON GENOME ORGANIZATION AND EVOLUTION OF THE FINANCING OF MALARIA CONTROL AND RESEARCH IXODIDAE Carlos C. (Kent) Campbell Jason Meyer PATH Malaria Control and Evaluation Program in Africa (MACEPA), Seattle, WA, Purdue University, West Lafayette, IN, United States United States

62 ASTMH 58th Annual Meeting www.astmh.org

10:40 a.m. 11:10 a.m. MALARIA FUNDING IN THE GATES FOUNDATION: A ARYLIMIDAMIDES – REVERSING THE LIMITATIONS OF VICTIM OF ITS OWN SUCCESS DIAMIDINES AGAINST LEISHMANIASIS David Brandling-Bennet Karl Werbovetz Bill & Melinda Gates Foundation, Seattle, WA, United States The Ohio State University, Columbus, United States 11:05 a.m. 11:35 a.m. THE IMPACT OF REDUCED GLOBAL FUNDING ON THE LOOKING AHEAD – NEW CANDIDATES FOR THE AIDS AND TB PANDEMICS TREATMENT OF HAT AND VL James Chin Michael Barrett University of California at Berkeley, Berkeley, CA, United States University of Glasgow, Glasgow, United Kingdom 11:30 a.m. Symposium 15 NEW VACCINES IN DEVELOPING COUNTRIES: WILL IT BE FEAST OR FAMINE? Mathematical Models to Support Malaria Control and Jon Andrus Elimination Pan American Health Organization, Washington, DC, United States Delaware B Symposium 14 Thursday, November 19, 10:15 a.m. - Noon

Some of the fi rst mathematical models for infectious disease transmission were New Drugs against Human African Trypanosomiasis and developed by Ross as he organized a malaria control program in Mauritius. Visceral Leishmaniasis - Activities of the Consortium for Subsequently, during the Global Malaria Eradication Program (1955-1969), Parasitic Drug Development Macdonald extended these models and integrated the ideas into the design and interpretation of outcomes. More recently, and with the availability of Delaware A computing technologies, a range of different models have been developed Thursday, November 19, 10:15 a.m. - Noon to understand key features of malaria dynamics and to explore the impact of interventions on control of the parasite. This symposium will provide an The mission of the non-profi t Consortium for Parasitic Drug Development overview of some of the ways in which models are currently being used to (CPDD) is to discover and develop new treatments for human African inform the fi ght against malaria in a form that is accessible to those with no

trypanosomiasis (HAT or sleeping sickness) and visceral leishmaniasis. technical background. Thursday, November 19 These diseases threaten nearly half the world’s population and cause massive disability, death and economic loss. Led by the University of North Carolina CHAIR at Chapel Hill, the CPDD also benefi ts from the participation of numerous Azra Ghani academic, public, and private partner institutions. The initial efforts of the Imperial College London, London, United Kingdom CPDD were focused on the development of the diamidine prodrug DB289 David L. Smith (pafuramidine) as an oral agent for the treatment of fi rst stage HAT. Through University of Florida, Gainsville, FL, United States the efforts of CPDD partners, DB289 progressed through Phase I, II, and III trials, with the HAT trials being conducted under challenging conditions 10:15 a.m. in central Africa (mainly in the Democratic Republic of the Congo). While diamidines remain a focus area for the CPDD, other classes of compounds LEARNING FROM THE PAST: APPLICATIONS TO are now being considered as candidates for second stage HAT and VL. The ELIMINATION IN ZANZIBAR symposium will update the status of DB289 and will also discuss the various David L. Smith discovery and development efforts that are currently in progress. University of Florida, Gainesville, FL, United States CHAIR 10:35 a.m. Karl Werbovetz SETTING THE AGENDA: HOW MODELS CAN HELP TO The Ohio State University, Columbus, OH, United States IDENTIFY APPROPRIATE STRATEGIES Richard Tidwell The University of North Carolina School of Medicine, Chapel Hill, NC, United States Azra Ghani Imperial College London, London, United Kingdom 10:15 a.m. 10:55 a.m. CLINICAL EXPERIENCES WITH DB289 TACKLING CURRENT PROBLEMS: MODELLING Carol Olson MALARIA ELIMINATION IN CAMBODIA Consortium for Parasitic Drug Development, Chapel Hill, NC, United States Richard Maude 10:45 a.m. Mahidol University, Bangkok, Thailand DEVELOPMENT OF CPD-0801 AS A CANDIDATE FOR 11:15 a.m. SECOND STAGE HAT TACKLING CURRENT PROBLEMS: CONTEXT-SPECIFIC James E. Hall EFFECTS OF INTERVENTIONS The University of North Carolina, Chapel Hill, NC, United States Phillip Eckhoff Intellectual Ventures, Bellevue, WA, United States

63 www.astmh.org Detailed Program

11:40 a.m. 11 a.m. LOOKING TO THE FUTURE: COMBINING OLD AND NEW 25 INTERVENTIONS Nakul Chitnis THE BEST APPROACH TO RETREATING PATIENTS WITH Swiss Tropical Institute, Basel, Switzerland RECURRENT MALARIA IN THE ERA OF ARTEMISININ Scientifi c Session 16 BASED COMBINATION THERAPY Yeka Adoke1, Ambrose O. Talisuna1, Umberto D’Alessandro2 1Uganda Malaria Surveillance Project, Kampala, Uganda, 2Institute of Tropical Malaria - Chemotherapy Medicine, Antwerp, Belgium Virginia AB 11:15 a.m. Thursday, November 19, 10:15 a.m. - Noon 26 CHAIR Yeka Adoke EFFICACY AND SAFETY OF QUININE VS. ARTEMETHER- Uganda Malaria Surveillance Project, Kampala, Uganda LUMEFANTRINE IN UNCOMPLICATED MALARIA Patrice Piola DURING PREGNANCY, MBARARA, UGANDA Epicentre, London, United Kingdom Patrice Piola1, Carolyn Nabasumba2, Eleanor Turyakira2, Mehul Dhorda2, 3 4 5 6 10:15 a.m. Carole Fogg , Georges Snounou , Elizabeth Ashley , Karen I. Barnes , Rose McGready7, François Nosten7, Philippe J. Guerin8 1Epicentre, Paris, France, 2Epicentre, Mbarara, Uganda, 3Drug Safety Research Unit, 22 Southampton, United Kingdom, 4INSERM UMR S 945, Paris, France, 5Imperial College NHS Trust, London, United Kingdom, 6Cape Town University, Cape Town, EFFECTS OF INCREASING ARTESUNATE DOSE South Africa, 7Shoklo Malaria Research Unit, Tak, Thailand, 8WWARN, Oxford, IN SEVEN-DAY MONOTHERAPY REGIMENS ON United Kingdom TREATMENT RESPONSE IN CAMBODIAN PATIENTS 11:30 a.m. WITH UNCOMPLICATED FALCIPARUM MALARIA Youry Se1, Chanthap Lon1, Duong Socheat2, Delia Bethell1, Sabaithip 27 Sriwichai1, David Saunders1, Stuart Tyner1, Sea Darapiseth2, Phisit Khemawoot1, Jessica Lin1, Sok Poeu2, Ses Sarim3, Ans Timmermans1, Wiriya Rutvisuttinunt1, Paktiya Teja-Isavadharm1, Kurt Schaecher1, Bryan Smith1, EPOIETIN BETA-QUININE DRUG COMBINATION IN Mark Fukuda1 CHILDREN WITH CEREBRAL MALARIA 1Armed Forces Research Institute of the Medical Sciences, Bangkok, Thailand, 2Center for Stephane Picot1, Anne-Lise Bienvenu1, Salimata Konate2, Sibiri Sissoko2, Parasitology, Entomology and Malaria Control, Pnom Penh, Cambodia, 3Tasanh Health Abdoulaye Barry2, Elisabeth Diarra2, Karidiatou Bamba2, Abdoulaye Djimde2, Center, Samlot, Cambodia Ogobara Doumbo2 1Malaria Research Unit, University Lyon 1, Lyon, France, 2Malaria Research and 10:30 a.m. Training Center, University of Bamako, Bamako, Mali 23 11:45 a.m.

EFFICACY OF THREE DIFFERENT REGIMENS OF 28 PRIMAQUINE FOR THE PREVENTION OF RELAPSES OF PLASMODIUM VIVAX MALARIA IN THE AMAZON BASIN OF MASS DRUG ADMINISTRATION: IS IT NECESSARY FOR PERU MALARIA ELIMINATION? Salomon Durand1, Cesar Cabezas2, Carlos Alvares Antonio3, Mariella Galves Michelle L. Gatton1, Qin Cheng2 1 2 Montoya3, Carmen Montalvan3, Andrea McCollum4, Valeria Soberon1, Queensland Institute of Medical Research, Herston, Australia, Australian Army Venkatachalam Udhayakumar4, Carmen M. Lucas1, Paul C. Graf1, David J. Malaria Institute, Brisbane, Australia Bacon1 1Naval Medical Research Center Detachment, Lima, Peru, 2National Health Institute Symposium 17 (INS), Lima, Peru, 3Regional Health Directorate of Loreto, Iquitos, Peru, 4Centers for Disease Control and Prevention, Atlanta, GA, United States Rickettsioses in Asia - Recent Developments 10:45 a.m. Virginia C 24 Thursday, November 19, 10:15 a.m. - Noon The symposium will present new and exciting information on the epidemiology MEASURING PREVENTATIVE DRUG EFFICACY and pathophysiology of scrub and murine typhus in Asia, on the rediscovery of OF SULFADOXINE/PYRIMETHAMINE (SP) PLUS sennetsu and on molecular markers of drug resistance in Rickettsia and Orientia ARTESUNATE (ART) THREE DAYS IN THE CONTEXT species. OF AN INTERMITTENT PREVENTATIVE TREATMENT IN INFANT (IPTI) STUDY IN PAPUA NEW GUINEA CHAIR Nicolas Senn1, Celine Barnadas2, Michele Senn3, Doris Manong3, Ivo Mueller2 Paul Newton 1Swiss Tropical Institute, Basel, Switzerland, 2PNG Institute of Medical Research, Goroka, University of Oxford, Oxford, United Kingdom Papua New Guinea, 3PNG Institute of Medical Research, Madang, Papua New Guinea Nicholas Day University of Oxford, Oxford, United Kingdom

64 ASTMH 58th Annual Meeting www.astmh.org

10:15 a.m. 10:45 a.m. EPIDEMIOLOGY OF RICKETTSIAL INFECTIONS IN LAOS 31 Rattanaphone Phetsouvanh Microbiology Laboratory, Vientiane, Lao People’s Democratic Republic DISSECTING THE POLYCLONAL HUMAN ANTIBODY 10:40 a.m. RESPONSE TO DENGUE VIRUS NEORICKETTSIA SENNETSU IN LAOS Aravinda M. de Silva, WMPB Wahala, Adamberage R. de Alwis, Anne Broadwater, Dirk P. Dittmer Paul Newton University of North Carolina School of Medicine, Chapel Hill, NC, United States Mahosot Hospital, Vientiane, Lao People’s Democratic Republic 11 a.m. 11:05 a.m. THE COMPARATIVE PATHOPHYSIOLOGY OF SCRUB 32 AND MURINE TYPHUS ASSESSING THE ACCURACY OF INFERRING THE Daniel Paris Mahidol University, Bangkok, Thailand SEROTYPE OF DENGUE VIRUS INFECTIONS BASED ON PRE- AND POST-INFECTION NEUTRALIZING ANTIBODY 11:30 a.m. TITERS MOLECULAR TARGETS OF ANTIBIOTIC RESISTANCE IN Wilbert Van Panhuis1, Robert V. Gibbons2, Tim Endy3, Donald S. Burke4, RICKETTSIAL INFECTIONS Derek A. Cummings1 1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, Jean-Marc Rolain 2Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand, 3SUNY- University of Marseille, Marseille, France Buffalo, Buffalo, NY, United States, 4University of Pittsburgh, Pittsburgh, PA, United States Scientifi c Session 18 11:15 a.m. Flavivirus - Dengue I 33 Washington 1 Thursday, November 19, 10:15 a.m. - Noon INVESTIGATION OF ANTIBODY DEPENDENT ENHANCEMENT IN HUMAN PRIMARY TARGET CELLS

CHAIR Kobporn Boonnak, Kaitlyn M. Dambach, Gina C. Donofrio, Mary A. Thursday, November 19 Aravinda M. de Silva Marovich University of North Carolina School of Medicine, Chapel Hill, NC, United States The Henry M. Jackson Foundation, Rockville, MD, United States Allison Imrie University of Hawaii at Manoa, Honolulu, HI, United States 11:30 a.m. 10:15 a.m. 34

29 INHIBITION OF DOWNSTREAM MEDIATORS OF THE TYPE I INTERFERON RESPONSE IN DENGUE VIRUS THE LENGTH AND NON-HYDROPHOBIC RESIDUES IN INFECTED MONOCYTE-DERIVED DENDRITIC CELLS THE TRANSMEMBRANE DOMAIN OF DENGUE VIRUS AND BYSTANDER T CELL ACTIVATION ENVELOPE PROTEIN CRITICAL FOR RETENTION AND Amanda J. Chase, Freddy A. Medina, Jorge L. Muñoz-Jordán ASSEMBLY IN ENDOPLASMIC RETICULUM Dengue Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, San Juan, PR, United States Wei-Kung Wang1, Szu-Chia Hsieh2, Wen-Yang Tsai2 1University of Hawaii at Manoa, Honolulu, HI, United States, 2Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan 11:45 a.m. (ACMCIP Abstract) 35 10:30 a.m. ANTIVIRAL ACTIVITY OF ANTI-DENGUE INHIBITORS IN 30 HUMAN PRIMARY DENDRITIC CELLS Hassan Javanbakht, Andreas Jekle, Suping Ren, Nick Cammack, Gabrielle IMMUNODOMINANCE IN DENGUE VIRUS INFECTION Heilek Allison Imrie1, Munkhzul Sukhbaatar2, Janet Meeks2, Claudine Roche3, Van- Roche, Palo Alto, CA, United States Mai Cao-Lormeau3 1University of Western Australia, Perth, Australia, 2University of Hawaii at Manoa, Honolulu, HI, United States, 3Institut Louis Malardé, Papeete, French Polynesia

65 www.astmh.org Detailed Program

Symposium 19 10:15 a.m. 36 Gametocytes and Gametocytogenesis: Tackling Malaria Transmission in the Era of Elimination IDENTIFICATION OF POTENTIAL BIOMARKERS Washington 2 FOR ANTIMONY SUSCEPTIBILITY/RESISTANCE IN L. Thursday, November 19, 10:15 a.m. - Noon DONOVANI Swati Dadhich1, Mahendra Maharjan1, Mitali Chatterjee2, Angana Gametocytes are essential for the transmission of the malaria parasite from Mukherjee1, Rentala Madhubala1 the human to the mosquito host and present a potential focus for strategies to 1School of Life Sciences, New Delhi, India, 2Institute of Post Graduate Medical Education reduce the burden of malaria infection. Understanding their basic cell biology and Research, Kolkata, India will help us develop new tools for malaria control en route to the ultimate (ACMCIP Abstract) goal of eradication. The speakers in this symposium will give an overview of research into gametocytes and gametocytogenesis in both lab- and fi eld-based 10:30 a.m. studies. Areas to be covered include in vivo studies based on murine models, fi eld based studies of both P. falciparum and P. vivax, and methods for assessing 37 the effect of antimalarial drugs on both commitment to gametocytogenesis and direct killing of mature stage gametocytes. Signaling mechanisms leading to CD4+ T CELLS SUBSETS IN HUMAN CUTANEOUS commitment and gametocyte production will also be considered. LEISHMANIASIS HAVE A DISTINCT RECEPTOR REPERTOIRES AND CYTOKINE EXPRESSION CHAIR Tatjana S. Keesen1, Lis R. Antonelli2, Luiz H. Guimarães3, Edgar M. Katharine R. Trenholme Carvalho3, Walderez O. Dutra1, Kenneth J. Gollob1 Queensland Institute of Medical Research, Brisbane, Australia 1Federal University of Minas Gerais, Belo Horizonte, Brazil, 2National Institutes of Donald L. Gardiner Health, Bethesda, MD, United States, 3Federal University of Bahia, Salvador, Brazil Queensland Institute of Medical Research, Brisbane, Australia (ACMCIP Abstract) 10:15 a.m. 10:45 a.m. GAMETOCYTOGENESIS IN P. FALCIPARUM AND P. VIVAX: 38 A FIELD PERSPECTIVE Ric Price MOLECULAR DIAGNOSIS, GENOTYPING AND FOLLOW- Menzies School of Health Research, Darwin, Australia UP OF TRYPANOSOMA CRUZI LINEAGES IN CARDIAC 10:40 a.m. SAMPLES FROM PATIENTS WITH CHAGAS HEART DISEASE AND BLOODSTREAM AND REACTIVATION EXPERIMENTAL APPROACHES TO INVESTIGATING THE LESIONS AFTER HEART TRANSPLANTATION COMMITMENT TO GAMETOCYTOGENESIS Alejandro G. Schijman1, Juan M. Burgos1, Mirta Diez2, Carlos V. Vigliano2, Joanne Thompson Tomas Duffy1, Margarita Bisio1, Liliana Favaloro2, Carolina Cura1, Mariano University of Edinburgh, Edinburgh, United Kingdom J. Levin1, Roberto Favaloro2 1INGEBI, Buenos Aires, Argentina, 2I CyCV, Fundacion Rene Favaloro, Buenos Aires, 11:05 a.m. Argentina A SIGNALING PATHWAY THAT IS ESSENTIAL FOR P. FALCIPARUM GAMETOCYTOGENESIS AND WHY WE 11 a.m. THINK IT IS A GOOD DRUG TARGET 39 David Baker London School of Hygiene and Tropical Medicine, London, United Kingdom SERUM LIPID PROFILE, APOLIPOPROTEIN E 11:30 a.m. GENOTYPE AND VISCERAL LEISHMANIASIS INFECTION IN A NORTHEASTERN BRAZILIAN POPULATION THE EFFECT OF ANTIMALARIAL DRUGS ON 1 2 2 2 GAMETOCYTOGENESIS IN P. FALCIPARUM IN VITRO Adam P. Simons , Gloria R. Monteiro , Nubia N. Pontes , Taysa M. Feitosa , Upasna Gaur3, Richard D. Pearson4, Mary E. Wilson3, Selma M. Jeronimo2 Chris Peatey 1University of California-Davis, Sacramento, CA, United States, 2Federal University of Queensland Institute of Medical Research, Brisbane, Australia Rio Grande do Norte, Natal, Brazil, 3University of Iowa, Iowa City, IA, United States, 4University of Virginia, Charlottesville, VA, United States Scientifi c Session 20 (ACMCIP Abstract) 11:15 a.m. Kinetoplastida: Molecular Biology and Immunology Washington 3 40 Thursday, November 19, 10:15 a.m. - Noon CARBOHYDRATES DERIVED FROM PATHOGENS CHAIR PROMOTE DIFFERENTIAL IL-12 PRODUCTION IN Alejandro Schijman MACROPHAGES INGEBI-CONICET, Buenos Aires, Argentina Alex Osanya Lynn Soong Iowa State University, Ames, IA, United States University of Texas Medical Branch, Galveston, TX, United States (ACMCIP Abstract)

66 ASTMH 58th Annual Meeting www.astmh.org

11:30 a.m. 11:30 a.m. INTRODUCTION OF AN ENTEROTOXIN-BASED 41 ADJUVANT INTO ENTERIC VACCINES IMMUNOGENICIY OF TUBULIN-BASED SUBUNIT John Clements Tulane University School of Medicine, New Orleans, LA, United States VACCINE CANDIDATES WHICH PROTECT ANIMALS AGAINST CHALLENGE WITH TRYPANOSOMA BRUCEI BRUCEI Symposium 22 Elisabeth Knapp1, Monica Namayanja2, Kirby Steger1, Rosemary Flores1, Ann Nanteza2, Jessica Chichester1, George Lubega2, Roger Prichard3, National Institutes of Health and Tropical Medicine: Douglas Holtzman4, Vidadi Yusibov1 Supporting International Research and Career 1Fraunhofer USA Inc., Center for Molecular Biotechnology, Newark, DE, United States, Development - Part 2 2Department for Veterinary Parasitology and Microbiology, Makerere University, Kampala, Uganda, 3Institute of Parasitology, McGill University, Montreal, QC, Washington 5 Canada, 4The Bill and Melinda Gates Foundation, Seattle, WA, United States Thursday, November 19, 10:15 a.m. - Noon

11:45 a.m. This symposium, organized by the ASTMH Education Committee in collaboration with the National Institutes of Health, is designed to educate 42 young investigators, including graduate students, post-doctoral fellows, MD/ PhD students, clinicians interested in research and others in the structure QUANTIFICATION OF PARASITEMIA IN LEISHMANIA of the NIH, the review process and grantsmanship in order to maximize the DONOVANI-INFECTED HAMSTERS BY REAL-TIME PCR chances of obtaining competitive funding. Brian A. Vesely, Anuradha Srivastava Azliyati Azizan, Mark Sweat, Dennis Kyle CHAIR University of South Florida, Tampa, FL, United States Stephen Higgs University of Texas Medical Branch, Galveston, TX, United States Symposium 21 Adriana Costero National Institutes of Health, Bethesda, MD, United States Improving Global Health by Vaccination against Bacterial 10:15 a.m. Causes of Diarrheal Diseases THE PEER REVIEW PROCESS AT THE NATIONAL Washington 4 INSTITUTES OF HEALTH Thursday, November 19 Thursday, November 19, 10:15 a.m. - Noon Alexander D. Politis National Institutes of Health, Bethesda, MD, United States Combined with clean water and sanitation, vaccination against enteric pathogens represents a key component necessary for optimal reduction of the 10:40 a.m. health threat from diarrheal diseases. This symposium will focus on recent progress made towards achieving suitable vaccine candidates for the main GRANTS MANAGEMENT: WHAT YOU NEED TO KNOW bacterial causes of intestinal infections: ETEC, Shigella, cholera and typhoid. AFTER AWARD Mary Kirker CHAIR National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States Richard Ives Walker Program for Appropriate Technology in Health, Washington, DC, United States 11:05 a.m. Jan Agosti TRAINING FUNDING MECHANISMS Bill and Melinda Gates Foundation, Seattle, WA, United States Milton Hernandez National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States 10:15 a.m. CURRENT APPROACHES TO VACCINES AGAINST ETEC 11:30 a.m. AND SHIGELLA FUNDING OPPORTUNITIES FOR INTERNATIONAL Lou Bourgeois INVESTIGATORS Program for Appropriate Technology in Health, Washington, DC, United States Barbara Sina National Institutes of Health, Bethesda, MD, United States 10:40 a.m. NOVEL APPROACHES TOWARDS A PAN SHIGELLA VACCINE Cecil Czerkinsky International Vaccine Institute, Seoul, Republic of Korea 11:05 a.m. PHASE 3 RESULTS FROM CHOLERA AND TYPHOID TRIALS John Clemens International Vaccine Institute, Seoul, Republic of Korea

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Symposium 23 ARTHROPODS/ENTOMOLOGY - OTHER

Exploiting Tsetse Physiology for Sleeping Sickness Control 43 Wilson AB MAPPING SANDFLY-PLANT INTERACTION IN RELATION Thursday, November 19, 10:15 a.m. - Noon TO THEIR BREEDING SITES IN PERKERRA IRRIGATION This symposium will feature presentations that report on the recent discoveries SCHEME, KENYA related to tsetse’s immune, reproductive symbiotic physiologies that can be Fred A. Amimo exploited to prevent parasite transmission. Parasite infections in the vector in University of Eastern Africa, Baraton, Eldoret, Kenya the fi eld can also guide disease control efforts. 44 CHAIR Serap Aksoy SUPPORT OF FAR-FORWARD DISEASE SURVEILLANCE Yale University, New Haven, CT, United States OPERATIONS WITH DEPLOYABLE, REAL-TIME VECTOR- Mike J. Lehane BORNE DISEASE AGENT ANALYTIC CAPABILITY: Liverpool School of Tropical Medicine, Liverpool, United Kingdom ENHANCED AND EXPANDED APPLICATIONS 10:15 a.m. James A. Swaby 59th Medical Wing, Lackland Air Force Base, TX, United States FACTORS DETERMINING THE ESTABLISHMENT OF TRYPANOSOMES IN THE MIDGUT OF TSETSE FLIES 45 Lee Hanes Liverpool School of Tropical Medicine, Liverpool, United Kingdom PREVALENCE AND FINE-SCALE DISTRIBUTION OF RIFT VALLEY FEVER VIRUS AND WEST NILE VIRUS 10:40 a.m. IN MOSQUITOES DURING A RIFT VALLEY FEVER EXPLOITING TSETSE’S VIVIPAROUS REPRODUCTIVE OUTBREAK IN NORTHEASTERN PROVINCE, KENYA PHYSIOLOGY FOR POPULATION CONTROL Laura J. Sutherland1, Samuel Muiruri2, Eric M. Muchiri2, Laurie R. Gray1, Geoffrey Attardo Peter A. Zimmerman1, Amy G. Hise1, Charles H. King1, Angelle Desiree Yale University, New Haven, CT, United States LaBeaud1 1Case Western Reserve University, Cleveland, OH, United States, 2Ministry of Health, 11:05 a.m. Kenya, Nairobi, Kenya

IMPROVING THE COST-EFFECTIVENESS OF ARTIFICIAL 46 VISUAL BAITS FOR CONTROLLING THE TSETSE FLY GLOSSINA FUSCIPES FUSCIPES SPECIFICITY OF HOST CELLULAR IMMUNE RESPONSE Stephen Torr AGAINST SAND FLY SALIVA Natural Resources Institute, Kent, CT, United Kingdom Iva Rohousova1, Jan Drahota1, Marie Lipoldova2, Petr Volf1 11:30 a.m. 1Charles University in Prague, Prague, Czech Republic, 2Institute of Molecular Genetics, Academy of Science of the Czech Republic, Prague, Czech Republic POPULATIONS GENETICS DATA APPLIED FOR TSETSE (ACMCIP Abstract) CONTROL: A CASE IN UGANDA Jon Beadell 47 Yale University, New Haven, CT, United States DYNAMICS OF HOST ANTIBODY RESPONSE TO SAND Exhibit Hall Open/Light Lunch FLY SALIVA Michaela Vlkova, Iva Rohousova, Jitka Hostomska, Vera Volfova, Petr Volf Exhibit Hall A Charles University in Prague, Prague, Czech Republic Thursday, November 19, Noon - 1:30 p.m. (ACMCIP Abstract) Poster Session 24/Light Lunch 48

Poster Session A (#43 – 294 and Late Breakers) DISCOVERY, RESEARCH, DEVELOPMENT AND EPA REGISTRATION OF A NEW INSECT AND TICK Exhibit Hall B South REPELLENT: COMPARATIVE STUDIES TO OTHER Thursday, November 19, Noon - 1:30 p.m. COMMERCIAL REPELLENTS R. Michael Roe, Brooke W. Bissinger North Carolina State University, Raleigh, NC, United States

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49 CESTODES – ECHINOCOCCOSIS/HYTATID DISEASE GENOME ORGANIZATION OF TANDEMLY-REPETITIVE DNA IN IXODES SCAPULARIS, THE LYME DISEASE TICK Jason M. Meyer1, Timothy J. Kurtti2, Catherine E. Silva1, Janice P. VanZee1, 55 Catherine A. Hill1 1Purdue University, Lafayette, IN, United States, 2University of Minnesota, St. Paul, A RODENT SPECIES (SPERMOPHILUS DAURICUS) MN, United States INFECTED WITH ECHINOCOCCUS GRANULOSUS IN NINGXIA,CHINA: A POTENTIALLY NEW MODE OF 50 HYDATID TRANSMISSION Yu R. Yang1, Philip S. Craig2, Akira Ito3, Patrick Giraudoux4, Jian Z. Zhang1, TRYPANOSOMA CRUZI MOLECULAR TYPING OF STRAINS Donald P. McManus5 FROM VECTORS IN YUCATAN, MEXICO 1Ningxia Medical University, Yinchuan City, Ningxia Hui Autonomous Region, China, Melba Herrera-Aguilar1, Maria Jesus Ramirez-Sierra1, Eric Dumonteil2 2Biomedical Sciences Research Institute and School of Environment and Life Sciences, 1Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico, 2Tulane University, New University of Salford, Salford, Greater Manchester, United Kingdom, 3Asahikawa Orleans, LA, United States Medical College, Asahikawa, Japan, 4Chrono-environment UMR UFC/CNRS 6249 usc INRA WHO Collaborating Centre for Prevention and Treatment of Human 51 Echinococcosis, University of Franche-Comte, Besancon, France, 5Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia BREEDING HABITATS FOR MALARIA VECTORS ASSOCIATED WITH A LAKE CESTODES - OTHER Noboru Minakawa1, Gabriel Dida2, George Sonye3, Kyoko Futami1 1Nagasaki University, Nagasaki, Japan, 2Maseno University, Maseno, Kenya, 3Springs 56 of Hope, Mbita, Kenya MESOCESTOIDIASIS: A NEW U. S. CASE AND THE 52 IMPORTANCE OF DIFFERENTIAL DIAGNOSIS IN CESTODE INFECTIONS IDENTIFICATION OF DAMAGED ADULT FEMALE CONTAINER-INHABITING AEDES MOSQUITOES IN LA Blaine A. Mathison1, Susan P. Montgomery2, Henry S. Bishop2, Stephanie P. Johnston2, Kim Winpisinger3, Robert Brems4, Boris Tsorin5, Steve York5, CROSSE VIRUS ENDEMIC AREAS Kevin Sohner5, Alexandre J. da Silva2 1 2 1 1 Michael R. Singleton , Bruce A. Harrison , Brian D. Byrd The Atlanta Education and Research Foundation, Decatur, GA and CDC-NCZVED- Thursday, November 19 1Western Carolina University, Cullowhee, NC, United States, 2North Carolina DENR, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA, Winston-Salem, NC, United States United States, 2CDC-NCZVED-Division of Parasitic Diseases, Atlanta, GA, United States, 3Zoonotic Disease Program, Ohio Department of Health, Reynoldsburg, OH, 53 United States, 4Muskingum County Health Department, Reynoldsburg, OH, United States, 5Ohio State Health Laboratory, Reynoldsburg, OH, United States A REMEDY FOR CHRONIC, NON-HEALING WOUNDS UNRESPONSIVE TO CONVENTIONAL THERAPY: CESTODES – TAENIASIS AND MAGGOT DEBRIDEMENT THERAPY CYSTICERCOSIS Mehmet Tanyuksel1, Engin Araz1, Ozgur Koru1, Senol Yildiz2, Hakan Ay2, Yuksel Yurttas3, Bulent Besirbellioglu4, Mustafa Deveci5, Zeynep Guclu Kilbas1 57 1Gulhane Military Medical Academy, Division of Medical Parasitology, Ankara, Turkey, 2Gulhane Military Medical Academy, Department of Underwater and Hyperbaric AN UNUSUAL CASE OF MYOCUTANEOUS 3 Medicine, Ankara, Turkey, Gulhane Military Medical Academy, Department of CYSTICERCOSIS MASQUERADING LUDWIG’S ANGINA Orthopaedics, Ankara, Turkey, 4Gulhane Military Medical Academy, Department of Infectious Diseases, Ankara, Turkey, 5Gulhane Military Medical Academy, Department Sangita Bhandary, Rakesh Singh, Prahlad Karki, Arvind K. Sinha of Plastic and Reconstructive Surgery, Ankara, Turkey BP Koirala Institute of Health Sciences, Koshi, Nepal

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MULTIPLEX PCR ASSAY FOR THE DETECTION AND HELMINTH GLYCANS INDUCE REFRACTORINESS SIMULTANEOUS DIFFERENTIATION OF CONTAINER- AGAINST IFN-G VIA TLR-2 LEADING TO MYELOID INHABITING AEDES MOSQUITOES IN LA CROSSE VIRUS DERIVED SUPPRESSOR CELL (MDSC) MEDIATED ENDEMIC AREAS IMMUNE REGULATION Brian D. Byrd1, James A. Goggins1, Dawn M. Wesson2 Marwa Ibrahim, Senarath Dissanayake 1Western Carolina University, Cullowhee, NC, United States, 2Tulane University, New UAE University, Al Ain, United Arab Emirates Orleans, LA, United States (ACMCIP Abstract)

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THE RELATIVE UTILITY OF RECOMBINANT AN OUTBREAK OF PUFFER FISH EGG POISONING IN PROTEINS AND ASSAY FORMATS FOR DETECTION OF SOUTHERN, COASTAL BANGLADESH CYSTICERCOSIS AND TAENIASIS Md. Saiful Islam1, Stephen P. Luby1, Mahmudur Rahman2, Shahana Patricia P. Wilkins1, Sukwan Handali1, Yeuk-Mui Lee1, John Noh1, Silvia Parveen1, Nusrat Homaira1, Nur Hur Begum2, Dawlat Khan1, Shammi Rodriguez2, Robert H. Gilman3, Armando Gonzalez4, Hector H. Garcia5, Akhter2, Emily S. Gurley1 Victor C. Tsang6 1International Centre for Diarrheal Diseases Research, Bangladesh, Dhaka, Bangladesh, 1Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, 2Institute of Epidemiology, Disease Control and Research, Ministry of Health and Family GA, United States, 2Instituto Nacional de Ciencias Neurológicas and Instituto Peruano Welfare, Government of Bangladesh, Mohakhali, Dhaka, Bangladesh de Parasitología Clínica y Experimental, Lima, Peru, 3Department of International Health, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, 65 MD, United States, 4School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru, 5Instituto Nacional de Ciencias Neurológicas, Instituto Peruano IDENTIFICATION OF MICROORGANISMS RELATES de Parasitología Clínica y Experimental, and Department of Microbiology, Universidad WITH SEPSIS IN ACUTE INFECTIONS IN THE INTENSIVE Peruana Cayetano Heredia, Lima, Peru, 6Division of Parasitic Diseases, Centers for Disease Control and Prevention and Georgia State University, Atlanta, GA, United CARE UNIT OF AN INSTITUTION OF HEALTH ATENTION States IN MONTERIA-CORDOBA, COLOMBIA Linda M. Chams, Alberto Mestra, Maria F. Yasnot CLINICAL TROPICAL MEDICINE Universidad de Córdoba, Monteria, Colombia 66 60 “I TOLD YOU SO”- WORDS OF WISDOM FROM YOUR CYSTICERCOSIS IN AN ISLAMIC STATE: MAKING THE WIFE IN PROTECTION FROM DENGUE FEVER CONNECTION IN A GLOBAL ENVIRONMENT! Lhissa N. Santana Parsotam R. Hira1, Faiza Al-Ali2, Nabila Khalid1, Fatma Shelahi2, Nadia Flushing Hospital Medical Center, Flushing, NY, United States A. Al-Enezy3, Fetouh Asfoor2, Jamshaid Iqbal1, Abrar Al Saffar2, Sayed M. Montazeri2, Mehraj Sheikh4 67 1Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait City, 2 Kuwait, Department of Laboratories, Farwaniya Hospital, Kuwait City, Kuwait, PHARMACOKINETIC PROFILES OF ARTESUNATE 3Department of Laboratories, Mubarak Al-Kabeer, Kuwait City, Kuwait, 4Department of Radiology, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait FOLLOWING MULTIPLE INTRAVENOUS DOSES OF 2, 4, AND 8 MG/KG IN HEALTHY VOLUNTEERS 61 R. Scott Miller1, Qigui Li1, Louis R. Cantilena2, Kevin J. Leary2, George A. Saviolakis2, Victor Melendez1, Peter J. Weina1 1 2 DENGUE INFECTION IN DIFFERENT AGE GROUPS Walter Reed Army Institute of Research, Silver Spring, MD, United States, Uniformed Services University of the Health Sciences, Bethesda, MD, United States Weerawan Hattasingh King Chulalongkorn Memorial Hospital, Bangkok, Thailand 68 62 TRAVEL-RELATED DISSEMINATED PENICILLIUM MARNEFFEI INFECTION IN A RENAL TRANSPLANT OUTPATIENT PNEUMOCOCCAL BACTEREMIA: RISK PATIENT FACTORS AND OUTCOMES IN BAMAKO, MALI Julie Hart, Ben Clark, Duncan McLellan, John Dyer Mamadou B. Sylla1, Souleymane Diallo1, Milagritos Tapia2, Mama N. Fremantle Hospital, Perth, Australia Doumbia1, Samba O. Sow1, Adama M. Keita1, Seydou Sissoko1, Nana Kourouma1, Nouhoun Telly1, Mamadou M. Keita1, Myron Levine3, Karen Kotloff2 69 1Centre pour le Developpement des Vaccins - Mali, Bamako, Mali, 2University of Maryland School of Medicine, Center for Vaccine Development, Baltimore, MD, United EMERGENCE OF ERYTHROMYCIN AND CLINDAMYCIN- States, 3University of Maryland School of Medicine, Baltimore, MD, United States RESISTANT STREPTOCOCCUS PYOGENES EMM 90 STRAINS IN HAWAII 63 Iris Chen, Carla Mizumoto, David Esaki, Guliz Erdem John A. Burns School of Medicine, Honolulu, HI, United States CONCOMITANT MALARIA PARASITEMIA AND BACTEREMIA IN HOSPITALIZED CHILDREN IN 70 BAMAKO, MALI Adama M. Keita1, Milagritos Tapia2, Samba O. Sow1, Souleymane Diallo1, COMPARATIVE FEATURES AND OUTCOMES OF P. Mahamadou M. Keita1, Mamadou B. Sylla1, Seydou Sissoko1, Nana FALCIPARUM MALARIA INFECTION IN GLUCOSE- 1 2 2 Kourouma , Myron Levine , Karen Kotloff 6-PHOSPHATE DEHYDROGENASE-NORMAL AND 1Centre pour le Developpement des Vaccins - Mali, Bamako, Mali, 2University of Maryland School of Medicine, Center for Vaccine Development, Baltimore, MD, United DEFICIENT CHILDREN AT A TERTIARY CARE HOSPITAL States IN IBADAN, NIGERIA Adebola E. Orimadegun1, Olugbemiro Sodeinde2 1Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria, 2Department of Paediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria

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MALARIA MISDIAGNOSIS IN UGANDA - IMPLICATIONS MICROBIOLOGICAL AND CLINICAL CHARACTERISTICS FOR POLICY CHANGE OF SHIGELLA SP. AS A CAUSE OF DIARRHEA AMONG Joaniter I. Nankabirwa1, Dejan Zurovac2, Julius N. Njogu2, Helen Counihan CHILDREN IN INDONESIA Counihan3, Robert W. Snow2, James K. Tibenderana4 Narain H. Punjabi1, Matthew R. Kasper1, Shannon D. Putnam1, Erlin 1Makarere University Kampala, Kampala, Uganda, 2Malaria Public Health and Listiyaningsih1, Endang Sedyaningsih2, Magdarina Agtini3, Bibiana W. Lay4, Epidemiology Group, KEMRI/Wellcome Trust Research Programme, Nairobi, Kenya, Yogiara Yogiara4 3Malaria Consortium, London, United Kingdom, 4Malaria Consortium, Africa Regional 1United States NAMRU-2 Jakarta, Jakarta, Indonesia, 2National Institute of Health Offi ce, Kampala, Uganda Research and Development, Jakarta, Indonesia, 3National Institute of Health, Research and Development, Jakarta, Indonesia, 4Atmajaya University Jakarta, Jakarta, ENTERIC INFECTIONS Indonesia 77 72 MULTI-RESISTANT SALMONELLA STRAINS ISOLATED

DETECTION OF BLACTX-M-15 EXTENDED-SPECTRUM FROM PATIENTS IN KUMASI, GHANA β -LACTAMASE GENES IN E. COLI FROM HOSPITAL Felix C. Mills-Robertson1, Stephen Owusu-Opoku2, Sammy C. Tay2, Olga PATIENTS IN NIGERIA Quasie1, Rebecca Asamoah1 1 Adekunle O. Olowe1, Mirjam Grobbel2, Britta Büchter3, Antina Lübke- Centre for Scientifi c Research into Plant Medicine, Mampong-akwapim, Ghana, 2 Becker3, A. Fruth4, Olayemi A.B5, Lothar H. Wieler3 Department of Clinical Microbiology, Kwame Nkrumah University of Science and 1Ladoke Akintola University of Technology, Osogbo, Osun State, Nigeria, 2Institutes for Technology, Kumasi, Ghana Microbiology and Epizootics, Freie University, Berlin, Berlin, Germany, 3Institutes for Microbiology and Epizootics, Freie University, Berlin, Germany, 4Robert Koch Institute, 78 Wernigerode Branch, Wernigerode, Germany, 5Department of Microbiology University of Ilorin, Ilorin, Nigeria CHANGING PATTERNS OF SHIGELLOSIS IN AN ANTIMICROBIAL RESISTANCE SURVEILLANCE 73 PROGRAM IN PERÚ, 2005-2008 Maria Bernal1, David Cepeda1, Enrique Canal1, Michael J. Gregory1, Rina SHIGELLA SEROTYPES AND ANTIBIOTIC SENSITIVITY Meza1, Victor R. Ocaña2, Eric R. Hall3, Ryan C. Maves1 IN AN URBAN SLUM CLINIC IN NAIROBI, KENYA 1United States Naval Medical Research Center Detachment - Peru, Lima, Peru, 2Centro

1 1 1 1 Thursday, November 19 Henry N. Njuguna , Emma Lebo , Hillary Omala , Leonard Otieno , de Salud I 4 Pachitea, Piura, Peru, 3United States Naval Medical Research Center, Silver 1 2 2 2 Benjamin Ochieng , Njenga Kariuki , Daniel Feikin , Robert F. Breiman Spring, MD, United States 1KEMRI/Centers for Disease Control and Prevention Kenya, Nairobi, Kenya, 2Centers for Disease Control and Prevention Kenya, Nairobi, Kenya 79 74 TRENDS IN ANTIMICROBIAL RESISTANCE AMONG BACTERIAL ENTEROPATHOGENS IN A MILITARY PREVALENCE OF I CLASS INTEGRON AMONG S. POPULATION IN THE PERUVIAN AMAZON, 2003-2009 FLEXNERI AND S. SONNEI IN UZBEKISTAN Ryan C. Maves1, David Cepeda1, Michael J. Gregory1, Jessica Vasquez2, Ruslan S. Madiyarov1, Aybek V. Khodiev1, Gulnara A. Ibadova1, C. Mason2 Rosa Burga2, Yocelinda Meza1, Juan Perez1, Luis Acosta3, Eric R. Hall4 1Scientifi c Research Institute of Epidemiology, Microbiology and Infectious Diseases, 1United States Naval Medical Research Center Detachment - Peru, Lima, Peru, 2United Tashkent, Uzbekistan, 2Armed Forces Research Institute of Medical Sciences, Bangkok, States Naval Medical Research Center Detachment - Peru, Iquitos, Peru, 3Vargas Guerra Thailand Army Base, Iquitos, Peru, 4United States Naval Medical Research Center, Silver Spring, (ACMCIP Abstract) MD, United States

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ENTEROAGGREGATIVE ESCHERICHIA COLI (EAEC) ASSOCIATION OF SINGLE-NUCLEOTIDE IN CHILDREN FROM FORTALEZA, CEARA, BRAZIL: POLYMORPHISMS (SNPS) IN THE AGGR GENE OF PREVALENCE, VIRULENCE FACTOR CODING GENES ENTEROAGGREGATIVE ESCHERICHIA COLI (EAEC) WITH AND INFLAMMATION ALTERATIONS IN THE CODIFIED AMINO ACIDS Ila F. Lima1, Josiane S. Quetz1, Alexandre Havt1, Jones B. Lima-Neto1, Ila F. Lima1, Alexandre Havt1, Josiane S. Quetz1, James P. Nataro2, Richard Lourrany B. Costa1, Rosa M. Mota1, James P. Nataro2, Richard L. Guerrant3, L. Guerrant3, Aldo A. Lima1 Aldo A. Lima1 1Federal University of Ceara, Fortaleza, Brazil, 2University of Maryland, Baltimore, 1Federal University of Ceara, Fortaleza, Brazil, 2University of Maryland, Baltimore, MD, United States, 3University of Virginia, Charlottesville, VA, United States MD, United States, 3University of Virginia, Charlottesville, VA, United States

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PREVALENCE AND VIRULENCE GENES ASSOCIATED WITH CAMPYLOBACTER SP. INFECTION: A 86 CASE-CONTROL STUDY ON CHILDREN FROM DENGUE VIRUS NONSTRUCTURAL PROTEINS INDUCE NORTHEASTERN BRAZIL IL-8 TRANSCRIPTION: ROLE OF VIRAL PROTEINS IN 1 1 1 1 Josiane S. Quetz , Ila F. Lima , Alexandre Havt , Eunice B. Carvalho , Rosa DENGUE IMMUNOPATHOGENESIS M. Mota1, Richard L. Guerrant2, Aldo A. Lima1 1Federal University of Ceara, Fortaleza, Brazil, 2University of Virginia, Charlottesville, James F. Kelley, Pakieli Kaufusi, Vivek R. Nerurkar VA, United States John A. Burns School of Medicine, Honolulu, HI, United States

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APOLIPOPROTEIN E4 STATUS INFLUENCES GROWTH AN ENTOMOLOGICAL STUDY ON RECEPTIVITY OF AND COGNITIVE RESPONSES TO MICRONUTRIENT DENGUE VECTORS OF SELECTED PUBLIC HOSPITALS SUPPLEMENTATION IN CHILDREN FROM NORTHEAST ADMITTING DENGUE PATIENTS IN METRO MANILA, BRAZIL PHILIPPINES Sumeet S. Mitter1, Reinaldo B. Oria2, Michelle P. Kvalsund3, Paula Estrella I. Cruz, Ferdinand Villanueva Salazar, Elizabeth Torres Carrier, Pamplona2, Rosa M. Mota2, Peter D. Patrick3, Aldo A. Lima2, Richard L. Wilfredo Escalante Aure, Ma. Rosario Zeta Capeding Guerrant3 Research Institute for Tropical Medicine, Metro Manila, Philippines 1David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA, United States, 2Federal University of Ceara, Fortaleza, Brazil, 3University of 88 Virginia, Charlottesville, VA, United States NATURAL ATTENUATION IN A SOUTH PACIFIC 83 OUTBREAK OF DENGUE TYPE-2 Argon Steel1, Duane J. Gubler2, Shannon N. Bennett1 ZINC SUPPLEMENTATION EXPOSES ASSOCIATIONS 1University of Hawaii at Manoa, Honolulu, HI, United States, 2Duke-NUS Graduate BETWEEN THE INTERLEUKIN 8 (-251 A/T) Medical School, Singapore, Singapore POLYMORPHISM AND MARKERS FOR HIGHER INTESTINAL INFLAMMATION IN CHILDREN FROM 89 NORTHEAST BRAZIL Sumeet S. Mitter1, Alexandre Havt2, Sean R. Moore3, Rosa M. Mota2, DENGUE IN DIFFERENT AGE GROUPS Reinaldo B. Oria2, Richard L. Guerrant4, Aldo A. Lima2 Weerawan Hattasingh 1David Geffen School of Medicine at University of California at Los Angeles, Los King Chulalongkorn Memorial Hospital, Bangkok, Thailand Angeles, CA, United States, 2Federal University of Ceara, Fortaleza, Brazil, 3Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 4University of 90 Virginia, Charlottesville, VA, United States

84 A POTENTIAL ROLE OF PLATELETS IN MATURATION OF DENGUE VIRUS CRYPTOSPORIDIUM SPP. AND ENTEROAGGREGATIVE Sansanee Noisakran1, Nattawat Onlamoon1, Hui Mien Hsiao1, Kulkanya 2 1 1 1 E. COLI INFECTION AND LACTOFERRIN LEVELS IN Chokephaibulkit , Francois Villinger , Aftab Ansari , Guey Chuen Perng 1Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory CHILDHOOD DIARRHEA IN ACCRA, GHANA University School of Medicine, Atlanta, GA, United States, 2Department of Pediatric, J.A. Opintan1, P.F. Ayeh-Kumi2, R. Gepi-Attee3, J.E. Sevilleja1, J.K. Roche1, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand J.P. Nataro4, C.A. Warren1, R.L. Guerrant1 1Center for Global Health, Division of Infectious Diseases and International Health, 91 Charlottesville, VA, United States, 2Department of Microbiology, University of Ghana 3 Medical School, Accra, Ghana, Princess Louise Marie Children’s Hospital, Accra, VALIDATION OF A MULTIPLEX MICROSPHERE-BASED Ghana, 4Center for Vaccine Development, Department of Pediatrics and Medicine, Baltimore, MD, United States IMMUNOASSAY FOR MEASUREMENT OF ANTI-DENGUE VIRUS IMMUNOGLOBULIN ANTIBODIES 85 Esther M. Volper, Haiyan Olekszak, Bruce Cropp, Janet Meeks, Allison J. Johnson, Allison Imrie, Duane J. Gubler, Vivek R. Nerurkar GEOGRAPHIC CHARACTERISTICS OF CHILDREN University of Hawaii, Honolulu, HI, United States WITH MODERATE-TO-SEVERE DIARRHEA IN RURAL WESTERN KENYA, 2008 Benjamin L. Nygren1, Richard Omore2, Maurice Ombok2, Ciara E. O’Reilly1, Benjamin Ochieng2, Fenny Moke2, Allen W. Hightower3, Karen Kotloff4, James P. Nataro4, Myron M. Levine4, Tamar Farag4, Eric D. Mintz1, Robert F. Breiman3 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Centers for Disease Control and Prevention/Kenya Medical Research Institute, Kisumu, Kenya, 3Centers for Disease Control and Prevention, Nairobi, Kenya, 4University of Maryland, Baltimore, MD, United States

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ANALYSIS OF HUMORAL IMMUNOLOGIC RESPONSE EVALUATION OF AN IMPROVED ELISA FOR DETECTION IN MICE IMMUNIZED BY DNA VACCINE ENCODING OF DENGUE NS1 PRM/E PROTEIN OF DENGUE VIRUS SEROTYPE Catriona McElnea, Jessica Warren, Lynette Mateo, Andrea Valks 2 ADMINISTERED THROUGH GENE GUN AND Inverness Medical Innovations Australia, Brisbane, Australia INTRAMUSCULAR ROUTES Day-yu Chao1, Wen-Fan Shen2, Han-Chung Wu2, Gwong-Jeng Chang3, Chuan-Liang Kao4, Shu-Fan Jwan4, Chwan-Chuen King5 1Institute of Veterinary Public Health, Taichung, Taiwan, 2Institute of Cellular and GLOBAL HEALTH Organismic Biology, Academia Sinica, Taipei, Taiwan, 3Division of Vector-borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, 98 United States, 4Institute of Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, 5Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan THE MAKING OF A WORLD ATLAS OF INFECTIOUS DISEASES 93 Heiman F. Wertheim1, Peter Horby1, Thanh Le Viet1, Thuy Nguyen Thi Thanh1, John P. Woodall2 STUDY OF THE REPLICATION OF DENGUE-2 VIRUS IN 1Oxford University, Hanoi, Vietnam, 2ProMED Mail, Rio de Janeiro, Brazil U937 CELLS UNDER THE ACTION OF CHLOROQUINE 99 Kleber Juvenal Farias, Paula Renata Machado, Benedito Antonio Fonseca University of Sao Paulo, Ribeirao Preto, Brazil ANEMIA OF INFLAMMATION IS RELATED TO 94 COGNITIVE IMPAIRMENT AMONG CHILDREN IN LEYTE, THE PHILIPPINES TRENDS IN PATTERNS OF DENGUE TRANSMISSION Courtney L. Olson1, Luz P. Acosta2, Natasha S. Hochberg3, Remigio M. OVER FOUR YEARS OF A PEDIATRIC COHORT STUDY Olveda2, Mario Jiz1, Stephen T. McGarvey4, Jonathan D. Kurtis1, David C. 5 1 IN NICARAGUA Bellinger , Jennifer F. Friedman 1Center for International Health Research, Rhode Island Hospital, Providence, RI, 1 1 1 1 Angel Balmaseda , Juan Carlos Mercado , Yolanda Tellez , Saira Saborío , United States, 2Research Institute for Tropical Medicine, Manila, Philippines, 3Emory 2 3 4 1 Katherine Standish , Matthew R. Henn , Edward C. Holmes , Andrea Nuñez , University Hospital, Department of Medicine, Atlanta, GA, United States, 4Epidemiology 2 5 6 5 William Avilés , Aubree Gordon , Guillermina Kuan , Eva Harris Section, Department of Community Health and International Health Institute, Brown 1 Thursday, November 19 Departamento de Virología, Centro Nacional de Diagnóstico y Referencia, Ministerio University, Providence, RI, United States, 5Department of Environmental Health, 2 de Salud, Managua, Nicaragua, Sustainable Sciences Institute, Managua, Nicaragua, Harvard School of Public Health, Boston, MA, United States 3Broad Institute, Cambridge, MA, United States, 4Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, 100 PA, United States, 5Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States, 6Socrates Flores Vivas Health Center, Managua, Nicaragua WORTH ITS WEIGHT IN GOLD- INTERVENOM- A GLOBALLY ACCESSIBLE INTERNET DATABASE TO 95 DOCUMENT AND QUANTIFY THE GLOBAL BURDEN OF MORBIDITY AND MORTALITY FROM SNAKE NEUTRALIZING ANTIBODIES AGAINST DENGUE VIRUS ENVENOMATION AND TO IMPROVE MANAGEMENT TYPE-1 MAP TO DOMAIN III OF THE E PROTEIN AND AND OUTCOME PROTECT MICE FROM LETHAL CHALLENGE Alexander Kumar1, Kathy Duong2 Bimmi Shrestha1, James D. Brien1, Soila Sukupolvi-Petty1, Kathryn 1Royal Sussex County Hospital, Brighton, United Kingdom, 2Royal Free Hampstead O’Brien1, Steevenson Nelson2, Theodore C. Pierson2, Michael S. Diamond1 NHS Trust, London, United Kingdom 1Washington University School of Medicine, St. Louis, MO, United States, 2National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 101 MD, United States GLOBAL HEALTH AS IT RELATES TO 96 GASTROINTESTINAL ILLNESSES IN THE CARIBBEAN REGION INDEX CLUSTER STUDY OF DENGUE VIRUS INFECTION SueMin Nathaniel-Girdharrie, Dave Chadee IN NICARAGUA University of the West Indies, St. Augustine, Trinidad and Tobago Miguel Reyes1, Juan Carlos Mercado2, Guillermina Kuan1, Juan Carlos Matute2, Oscar Ortega3, Berman Moraga2, Matthew R. Henn4, Katherine 102 Standish3, William Avilés3, Angel Balmaseda2, Eva Harris5 1Socrates Flores Vivas Health Center, Managua, Nicaragua, 2Departamento de Virología, DETERMINANTS OF HEALTH SEEKING BEHAVIOR Centro Nacional de Diagnóstico y Referencia, Ministerio de Salud, Managua, Nicaragua, 3Sustainable Sciences Institute, Managua, Nicaragua, 4Broad Institute, Cambridge, MA, AMONG FAMILIES OF SICK YOUNG INFANTS IN A United States, 5Division of Infectious Diseases and Vaccinology, School of Public Health, COMMUNITY SETTING IN KARACHI University of California, Berkeley, Berkeley, CA, United States Aatekah Owais1, Shazia Sultana1, Aryeh D. Stein2, Nasira H. Bashir1, Razia Awaldad1, Anita K. Zaidi1 1Aga Khan University, Karachi, Pakistan, 2Emory University, Atlanta, GA, United States

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VALIDATION STUDY OF EDINBURGH POSTNATAL THE EPIDEMIC SITUATION OF SEVERAL MAIN DEPRESSION SCALE IN MADAGASCAR INFECTIOUS DISEASES AND THEIR THREATS TO Jyoti K. Randhawa, Richard R. Roach, Shama Ruqiya Tareen, Michael R. GLOBAL PUBLIC HEALTH SECURITY Liepman Lingmei Shi, Shukeng Zhang, Li Yang, Wanen Lin Michigan State University/Kalamazoo Center for Medical Studies, Kalamazoo, MI, International Travel Healthcare Center, Fujian Entry-Exit Inspection and Quarantine United States Bureau, Fuzhou, China

104 111

INTEGRATING A CLINICAL TRIAL AND A PUBLIC END-TO-END DISEASE SURVEILLANCE IN DEVELOPING HEALTH INITIATIVE: OPPORTUNITIES AND NATIONS CHALLENGES Joseph F. Skora1, Richard Seagraves1, Richard A. Wojcik1, Gianni Heather E. Kelly, Barbara Hickingbottom, Louise Johnson, Karen Schlein, Nakandakare2, Joan Neyra2, Raj Ashar1, Delphis Vera2, Richardo Hora2, Joel Suzanne Welty, Rhonda Sarnoff Montgomery2, Sheri Lewis1, David Blazes3 Institute for OneWorld Health, San Francisco, CA, United States 1Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States, 2United States Naval Medical Research Center Detachment, Lima, Peru, 3Department 105 of Defense Global Emerging Infections and Response System, Silver Spring, MD, United States FACTORS INFLUENCING COMMUNITY DYNAMICS IN INTEGRATED NEGLECTED TROPICAL DISEASE HELMINTHS – NEMATODES – FILARIASIS INTERVENTIONS IN NIGERIA (CLINICAL) Kathryn Welter1, Deborah McFarland1, Frank O. Richards, Jr.2, John Umaru3, Abel Eigege3, Priscillia Dewa3 1Rollins School of Public Health, Emory University, Atlanta, GA, United States, 2The 112 Carter Center, Atlanta, GA, United States, 3The Carter Center, Jos, Nigeria A SUSTAINABLE NATIONWIDE LYMPHOEDEMA 106 PROJECT IN TOGO Gbati Datagni1, Ameyo Dorkenoo1, Erika Pearl2, Yao Sodahlon3, Els SPATIAL ANALYSIS AND DISEASE MAPPING: TOOLS Mathieu4 FOR PLANNING AND EVALUATING INTEGRATED 1Ministère de la Sante, Lome, Togo, 2IMA Worldhealth, New Windsor, MD, United NEGLECTED TROPICAL DISEASE CONTROL IN SUB- States, 3Mectizan Donation Program, Atlanta, GA, United States, 4Centers for Disease Control and Prevention, Atlanta, GA, United States SAHARAN AFRICA Archie C. Clements1, Ricardo Soares Magalhaes1, Simon Brooker2, Alan 113 Fenwick3 1University of Queensland, Brisbane, Australia, 2London School of Hygiene and Tropical Medicine, London, United Kingdom, 3Imperial College London, London, United Kingdom PERSISTENCE OF WUCHERERIA BANCROFTI IN THE INSECT VECTOR DESPITE APPARENT ELIMINATION OF 107 INFECTION IN THE HUMAN POPULATION Yaya I. Coulibaly1, Benoit Dembele1, Abdallah Diallo1, Housseini Dolo1, PARTNERSHIP WITH A LOCAL REFUGEE COMMUNITY Siaka Konate1, Dramane Sanogo1, Siaka Y. Coulibaly1, Salif S. Doumbia1, TO DEVELOP STANDARDIZED CLINICAL SCENARIOS: Lamine Soumaoro1, Michel E. Coulibaly1, Abdel K. Traore2, Sekou F. Traore1 1Malaria Research and Training Center, Bamako, Mali, 2National Center for Disease AN EFFECTIVE TOOL FOR ASSESSING CULTURAL Control, Bamako, Mali COMPETENCY IN THE HEALTH CARE SETTING? William Hahn, Elizabeth Dawson-Hahn, Lynn Cleary, Steven Harris, Susan Stearns HELMINTHS – NEMATODES – FILARIASIS SUNY Upstate Medical University, Syracuse, NY, United States (EPIDEMIOLOGY)

108 114 THE PREVALENCE AND IMPACT OF THE CO- THE NATIONAL PROGRAM FOR THE ELIMINATION OF MORBIDITY OF SCABIES AND OTHER NEGLECTED LYMPHATIC FILARIASIS IN TOGO: A SUCCESS STORY TROPICAL DISEASES ON A COHORT OF CHILDREN IN THE SOUTH PACIFIC Améyo Dorkenoo1, Gbati M. Datagni1, Kodjo Morgah1, Els Mathieu2, Anders Seim3, Yao Sodahlon4 Sonia P. Harmen 1Ministère de la Sante, Lome, Togo, 2Centers for Disease Control and Prevention, Atlanta, James Cook University, Townsville, QLD, Australia GA, United States, 3Health and Development International, Fjellstrand, Norway, 4Mectizan Donation Program, Atlanta, GA, United States 109

JOSEPH JAMES KINYOUN: FOUNDING FATHER OF AMERICAN MICROBIOLOGY David M. Morens National Institutes of Health, Bethesda, MD, United States

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IS LYMPHATIC FILARIASIS TRANSMISSION COULD SNPS IN MDR-1 GENE CONTRIBUTE TO INTERRUPTED IN TOGO? OCCASIONAL SEVERE ADVERSE EFFECTS, FOLLOWING Ameyo Dorkenoo1, Els Mathieu2, Yao Sodahlon3 IVERMECTIN TREATMENT IN ONCHOCERCIASIS 1Ministère de la Sante, Lome, Togo, 2Centers for Disease Control and Prevention, Atlanta, PATIENTS, FROM CAMEROON, THAT WERE CO- GA, United States, 3Mectizan Donation Program, Atlanta, GA, United States INFECTED WITH LOA LOA? Catherine Bourguinat1, Joseph Kamgno2, Michel Boussinesq3, Charles 116 Mackenzie4, Timothy Geary1, Roger Prichard1 1Institute of Parasitology, McGill University, Sainte-Anne-de-Bellevue, QC, Canada, EVIDENCE FOR STOPPING MASS DRUG 2Filariasis Research Centre, Yaounde, Cameroon, 3Institut de Recherche pour le ADMINISTRATION FOR LYMPHATIC FILARIASIS (LF) IN Developpement, Montpellier, France, 4Michigan State University, Lansing, MI, United SOME, BUT NOT ALL LOCAL GOVERNMENT AREAS OF States PLATEAU AND NASARAWA STATES, NIGERIA 121 Jonathan D. King1, Abel Eigege2, John Umaru2, Nimzing Jip2, Emmanuel Miri2, Jonathan Jiya3, Patricia Graves1, Frank Richards1 1The Carter Center, Atlanta, GA, United States, 2The Carter Center, Jos, Nigeria, IDENTIFICATION OF PROTEINS BINDING TO THE 3Federal Ministry of Health, Abuja, Nigeria ESSENTIAL PROMOTER DOMAIN OF BRUGIA MALAYI 12 KDA SMALL SUBUNIT RIBOSOMAL PROTEIN (BMRPS12) HELMINTHS – NEMATODES – FILARIASIS GENE USING PHAGE-DISPLAY (MOLECULAR BIOLOGY) Chitra Chauhan, Thomas R. Unnasch Global Health Infectious Disease Research, Department of Global Health, College of Public Health, University of South Florida, Tampa, FL, United States 117 122 MICROARRAY-BASED ANALYSIS OF THE EFFECT OF DOXYCYCLINE ON BRUGIA MALAYI MICROFILARIAE THE BRUGIA MALAYI ANKYRIN DOMAIN CONTAINING WOLBACHIA PROTEINS AS POTENTIAL MEDIATORS OF Sivapong Sungpradit1, Jason Bailey2, Anne E. Jedlicka2, Alan L. Scott2, Surang Nuchprayoon1 ENDOSYMBIOSIS 1Lymphatic Filariasis Research Unit, Department of Parasitology, and Chulalongkorn Tiruneh Hailemariam

Medical Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok, New York Blood Center, New York, NY, United States Thursday, November 19 Thailand, 2The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD, United States 123 (ACMCIP Abstract) INFECTIVITY AND GENETIC ANALYSIS OF HYBRID 118 BRUGIA LARVAE

1 1 2 1 COMPARATIVE ANALYSIS OF GENE EXPRESSION Shelly Michalski , Kathryn Griffi ths , Sara Erickson , Rebecca Zink , Jeremy Fuchs2, Bruce Christensen2 PROFILES IN INFECTIVE LARVA OF BRUGIA MALAYI AND 1University of Wisconsin Oshkosh, Oshkosh, WI, United States, 2University of BRUGIA PAHANGI Wisconsin Madison, Madison, WI, United States Ramakrishna U. Rao1, Thomas R. Klei2, Yuefang Huang1, Krishna P. (ACMCIP Abstract) Shakya2, Michael Heinz1, Sahar Abubucker1, Makedonka Mitreva1, Gary J. Weil1 124 1Washington University School of Medicine, St. Louis, MO, United States, 2Louisiana State University, Baton Rouge, LA, United States DEVELOPMENTALLY REGULATED GENE EXPRESSION IN BRUGIA MALAYI 119 Benwen Li, Seth D. Crosby, Amy C. Rush, Dao Jun Jiang, Gary Weil Washington University School of Medicine, St. Louis, MO, United States ANALYSIS OF WOLBACHIA GENE EXPRESSION IN (ACMCIP Abstract) FILARIAL PARASITES BY IN SITU HYBRIDIZATION Daojun Jiang, Peter Fischer, Gary Weil Washington University, St. Louis, MO, United States

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KINETOPLASTIDA – DIAGNOSIS AND 132 TREATMENT IN VITRO PHARMACODYNAMICS AND MECHANISM OF ACTION STUDIES OF OXABOROLE 6-CARBOXAMIDES: A 125 NEW CLASS OF COMPOUNDS FOR THE TREATMENT OF AFRICAN TRYPANOSOMIASIS NOVEL LIPID BIOSYNTHETIC PATHWAYS IN Bakela Nare1, Luke Mercer1, Tana Bowling1, Matthew Orr1, Daitao Chen1, LEISHMANIA CHEMOTHERAPEUTICS Jessica Sligar1, Matthew Jenks1, Andy Noe1, Stephen Wring1, Cyrus Bacchi2, F. Matthew Kuhlmann, Bill Nolan, Beth Gohara, Fong-Fu Hsu, John Turk, Nigel Yarlett2, Yvonne Freund3, Jacob Plattner3, Kurt Jarnagin3, Robert Stephen M. Beverley Don4, Robert Jacobs1 Washington University, St. Louis, MO, United States 1SCYNEXIS, INC., Research Triangle Park, NC, United States, 2Pace University, New York, NY, United States, 3Anacor Pharmaceuticals Inc., Palo Alto, CA, United States, 126 4Drugs for Neglected Diseases initiative, Geneva, Switzerland (ACMCIP Abstract) DIAGNOSIS OF VISCERAL LEISHMANIASIS BY 133 POLYMERASE CHAIN REACTION OF DNA EXTRACTED FROM GIEMSA STAINED SLIDES COLLECTED FROM TOWARDS RATIONAL DRUG DESIGN IN NEPAL LEISHMANIASIS: PTERIDINE REDUCTASE 1 AS A Kishor Pandey1, Arun Kumar Mallik2, Basy Dev Pandey3, Osamu Kaneko4, TARGET FOR ANTIFOLATE CHEMOTHERAPY Tetsuo Yanagi4, Kenji Hirayama4 1Faculty of Agriculture, The University of Tokyo, Tokyo, Japan, 2Janakpur Zonal Neeloo Singh, Jaspreet Kaur Hospital, Janakpur, Nepal, Janakpur, Nepal, 3Sukraraj Tropical and Infectious Central Drug Research Institute, Lucknow, India Diseases Hospital, Kathmandu, Nepal, 4Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan 134

127 SYBR GREEN-BASED REAL-TIME PCR DIFFERENTIATION OF LEISHMANIA SPP. IN CLINICAL ISOLATED AND PURIFIED NOVEL ANTILEISHMANIAL SPECIMENS DRUG CANDIDATE FROM HIMATANTHUS SUCUUBA Ozgur Koru1, Marcos E. de Almeida2, Francis Steurer3, Barbara L. Renzo Perales, Jorge Arevalo Herwaldt3, Alexandre J. da Silva3 Instituto de Medicina Tropical “Alexander von Humboldt”, Lima, Peru 1Gulhane Military Medicine Academy, Department of Microbiology, Ankara, Turkey and (ACMCIP Abstract) Centers for Disease Control and Prevention-NCZVED-Division of Parasitic Diseases, Atlanta, GA, United States, 2Centers for Disease Control and Prevention-NCZVED- 129 Division of Parasitic Diseases and Atlanta Research and Education Foundation, Atlanta, GA, United States, 3Centers for Disease Control and Prevention-NCZVED-Division of Parasitic Diseases, Atlanta, GA, United States ORGAN SPECIFIC ACCUMULATION AND DISTRIBUTION (ACMCIP Abstract) OF STRUCTURALLY RELATED ANTI-TRYPANOSOMAL COMPOUNDS: A POSSIBLE ROLE IN RENAL TOXICITY MALARIA – BIOLOGY AND Rachel Beaulieu Goldsmith, Richard R. Tidwell University of North Carolina at Chapel Hill, Chapel Hill, NC, United States PATHOGENESIS (ACMCIP Abstract) 135 130 MALARIAL RETINOPATHY AND MICROCIRCULATION IN ANTIBODY DROP IN NEWBORNS CONGENITALLY ADULTS WITH CEREBRAL MALARIA INFECTED BY TRYPANOSOMA CRUZI TREATED WITH 1 2 3 BENZNIDAZOLE Richard J. Maude , Nicholas A. Beare , Abdullah A. Sayeed , Prakaykaew Charunwatthana1, M. Abul Faiz4, Amir Hossain4, Emran B. Yunus4, M. Jean-Philippe F. Chippaux1, Alejandra N. Salas Clavijo1, Jose A. Santalla2, Gofranul Hoque3, Mahtab U. Hasan3, Nicholas J. White1, Nicholas P. Day1, Jorge R. Postigo1, Mario E. Romero1, Eddy Espinoza2, Patricia Oporto2, Arjen M. Dondorp1 Tatiana Rios2, Dominique Schneider1, Laurent Brutus1 1Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand, 2St Paul’s Eye 1Institut de Recherche pour le Développement, Paris, France, 2Instituto Nacional de Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom, 3Chittagong Laboratorios de Salud, La Paz, Bolivia Medical College Hospital, Chittagong, Bangladesh, 4Malaria Research Group, Chittagong, Bangladesh 131

ACUTE INFECTION WITH TRYPANOSOMA CRUZI IN WISTAR RATS INDUCES GROWTH RETARDATION AND DEVELOPMENT OF MORPHOLOGICAL ANOMALIES IN THEIR FETUSES Ana Lugo-Yarbuh, Maritza Alarcon, Elio Moreno, Sonia Araujo Universidad de los Andes, Merida, Venezuela

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PLACENTAL MALARIA IN AREAS OF DIFFERENT ASSOCIATION BETWEEN POLYMORPHIC VARIATION ENDEMICITY: A MODIFIED PATHOLOGICAL GRADING IN THE IL12B 3’ UTR AND PROTECTION AGAINST SCHEME PLASMODIUM FALCIPARUM-INDUCED SEVERE MALARIAL Atis Muehlenbachs1, Michal Fried2, Rose McGready3, Corinne L. Fligner1, ANEMIA IN KENYAN CHILDREN Theonest K. Mutabingwa4, Francois Nosten3, Patrick E. Duffy2 Evans Raballah1, Samuel B. Anyona1, Collins Ouma1, Tom Were1, Gregory C. 1University of Washington, Seattle, WA, United States, 2Seattle Biomedical Research Davenport2, George Orinda3, Michael F. Oteino3, Douglas J. Perkins4, John Institute, Seattle, WA, United States, 3Shoklo Malaria Research Unit, Mae Sot, M. Ong’echa1 Thailand, 4National Institute for Medical Research, Dar es Salaam, United Republic of 1University of New Mexico/KMERI, Kisumu, Kenya, 2University of Pittsburgh, Tanzania Pittsburgh, PA, United States, 3Kenyatta University, Nairobi, Kenya, 4University of New (ACMCIP Abstract) Mexico, Albuquerque, NM, United States (ACMCIP Abstract) 137 142 ANGIOPOIETIN EXPRESSION IN POSTMORTEM HUMAN BRAIN IN CEREBRAL MALARIA LACK OF ASSOCIATION BETWEEN VARIATION AT TNF-α Panote Prapansilp1, Isabelle M. Medana1, Nicholas P. Day2, Nicholas J. -1031(T/C) AND SEVERE MALARIA ANEMIA White2, Nicholas M. Anstey3, Gareth D. Turner1 Henry O. Ndege1, Collins Ouma1, Gregory C. Davenport2, Tom Were1, 1Centre for Clinical Vaccinology and Tropical Medicine, Nuffi eld Department of Clinical Samuel B. Anyona1, Ayub V. Ofulla3, John M. Vulule4, Jeremy Martinson2, Medicine and Nuffi eld Department of Clinical Laboratory Sciences, University of Oxford, John M. Ong’echa1, Robert E. Ferrell2, Douglas J. Perkins5 Oxford, United Kingdom, 2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of 1University of New Mexico/KEMRI, Kisumu, Kenya, 2University of Pittsburgh, Tropical Medicine, Mahidol University, Bangkok, Thailand, 3Menzies School of Health Pittsburgh, PA, United States, 3Maseno University, Maseno, Kenya, 4KEMRI, Kisumu, Research, Darwin, Australia Kenya, 5University of New Mexico, Albuquerque, NM, United States (ACMCIP Abstract) 138 143 EFFECT OF CHLOROQUINE, METHYLENE BLUE AND ARTEMETHER ON HEPATIC OXIDATIVE STRESS AND MEASUREMENT OF PLASMODIUM FALCIPARUM ANTIOXIDANT ENZYMES IN P. YOELII-INFECTED MICE SEQUESTRATION IN HUMAN TISSUE Mary C. Oguike1, George O. Ademowo2 Regina C. Joice1, Danny A. Milner2, Jacqui Montgomery3, Karl B. Seydel4, 1 Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria, Terrie E. Taylor4, Matthias Marti1 Thursday, November 19 2Institute for Advanced Medical Research and Training, College of Medicine, University 1Harvard School of Public Health, Boston, MA, United States, 2The Brigham and of Ibadan, Ibadan, Nigeria Women’s Hospital, Boston, MA, United States, 3Malawi-Liverpool-Wellcome Trust (ACMCIP Abstract) Clinical Research Programme, Blantyre, Malawi, 4Michigan State University, East Lansing, MI, United States 139 144 DYSREGULATION OF ANGIOPOIETINS IN LOW BIRTH WEIGHT OUTCOMES OF PLACENTAL MALARIA IDENTIFYING THE COMPONENTS OF Karlee L. Silver1, Kathleen Zhong1, Rose G. Leke2, Diane Wallace Taylor3, INTRAERYTHROCYTIC PLASMODIUM FALCIPARUM THAT Kevin C. Kain1 INTERACT WITH GROWTH-PROMOTING LIPIDS 1McLaughlin-Rotman Centre for Global Health/University of Toronto, Toronto, Hiroko Asahi1, Shinji Izumiyama1, Bethel Kwansa-Bentum2, Mohammed ON, Canada, 2University of Yaounde, Yaounde, Cameroon, 3Georgetown University, Tolba3 Washington, DC, United States 1NIID, Japan, Tokyo, Japan, 2Tokyo Medical and Dental University, Tokyo, Japan, 3Assiut University, Assiut, Egypt 140 (ACMCIP Abstract)

HAPLOTYPES AND DIPLOTYPES OF INTERLEUKIN-18 145 PROMOTER POLYMORPHISMS ARE ASSOCIATED WITH SUSCEPTIBILITY TO SEVERE PEDIATRIC MALARIAL ANEMIA DURING PREGNANCY AND LOW BIRTH ANEMIA WEIGHT IN AN ENDEMIC MALARIA AREA IN BENIN Samuel B. Anyona1, Collins Ouma1, Gregory C. Davenport2, John Vulule3, Florence Bodeau-Livinec1, Valerie Briand2, Jacques Berger3, Xu Xiong4, Jeremy Martinson2, Robert E. Ferrell2, Charity W. Gichuki4, John M. Karen P. Day1, Achille Massougbodgi5, Michel Cot2 Ong’echa1, Douglas J. Perkins5 1New York University School of Medicine, New York, NY, United States, 2Institut 1University of New Mexico/KEMRI, Kisumu, Kenya, 2Universtiy of Pittsburgh, de Recherche pour le Developpement, Paris, France, 3Institut de Recherche pour le Pittsburgh, PA, United States, 3KEMRI, Kisumu, Kenya, 4Kenyatta University, Developpement, Montpellier, France, 4Tulane University, New Orleans, LA, United Nairobi, Kenya, 5University of New Mexico, Albuquerque, NM, United States States, 5Faculte des Sciences de la Sante, University of Abomey-Calavi, Cotonou, Benin (ACMCIP Abstract)

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PHASE DEPENDENT SUB-CELLULAR FREE CALCIUM CONCENTRATION WITHIN PLASMODIUM FALCIPARUM SEX-RELATED DIFFERENCES IN THE STEADY-STATE INFECTED ERYTHROCYTES PHARMACOKINETICS OF PRIMAQUINE IN HEALTHY Changan Xie, Paul D. Roepe SUBJECTS Georgetown University, Washington, DC, United States Vu Quoc Binh1, Nguyen Trong Chinh2, Nguyen Xuan Thanh1, Bui Tri (ACMCIP Abstract) Cuong1, Nguyen Ngoc Quang2, Bui Dai1, Thomas Travers3, Michael D. Edstein3 147 1Military Institute of Hygiene and Epidemiology, Hanoi, Vietnam, 2Central Military Hospital, Hanoi, Vietnam, 3Australian Army Malaria Institute, Brisbane, Australia P. FALCIPARUM CULTIVATION IN A SODIUM-FREE MEDIUM 153 Rachel Addo, Ajay D. Pillai, Sanjay A. Desai National Institute of Allergy and Infectious Diseases, National Institutes of Health, EFFECT OF EXOGENOUS ANGIOPOIETIN DURING Rockville, MD, United States EXPERIMENTAL CEREBRAL MALARIA (ACMCIP Abstract) Anne-Lise Bienvenu, Stephane Picot University Lyon 1, Lyon, France MALARIA - CHEMOTHERAPY 154

148 EMERGENCE, SEX RATIOS OF FIRST-APPEARING AND CLEARANCE OF PLASMODIUM FALCIPARUM THE USE OF ARTEMISININ-BASED COMBINATION GAMETOCYTES IN CHILDREN TREATED WITH THERAPIES (ACTS) IN PUBLIC SECONDARY HEALTH MEFLOQUINE OR ARTESUNATE-MEFLOQUINE FACILITIES IN LAGOS NIGERIA - AN INTERVENTION Akintunde Sowunmi, Oluchi Nkogho, Titilope Okuboyejo, Grace Gbotosho, STUDY Christian Happi Ibrahim A. Oreagba Department of Pharmacology and Therapeutics/Institute for Advanced Medical Research University of Lagos, Lagos, Nigeria and Training, University of Ibadan, Ibadan, Nigeria

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INTERMITTENT PREVENTIVE TREATMENT USING CLINICAL STUDIES ON PRIMAQUINE-INDUCED ARTEMISININ-BASED COMBINATION THERAPY HEMOLYSIS IN G6PD-DEFICIENT PATIENTS REDUCES MALARIA MORBIDITY AMONG SCHOOL- Hla Y. Myint1, Colin Ohrt1, Larry Walker2, Nick White3, Alan Magill1 AGED CHILDREN IN MALI 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2University of Mississippi, University, MS, United States, 3Mahidol-Oxford Research Unit, Mahidol Hamma Maiga1, Breanna Barger2, Oumar Bila Traore1, Mamadou Tekete1, University, Bangkok, Thailand Antimbe Timbine1, Antoine Dara1, Zoumana Isaac Traore1, Soren Gantt3, Ogobara Doumbo1, Abdoulaye Djimde1 1MRTC/DEAP, Bamako, Mali, 2University of Washington, Seattle, WA, United States, 156 3Department of Pediatrics, Seattle Children’s Hospital, WA, United States INCREASING ACCESS TO ARTEMESIN-BASED 150 COMBINATION THERAPY (ACT) IN POST-CONFLICT ENVIRONMENTS: THE EXPERIENCE OF SOUTHERN CURCUMIN ENHANCES NON-OPSONIC PHAGOCYTOSIS SUDAN OF PLASMODIUM FALCIPARUM BY UP-REGULATING Chris Warren, Lisa Hare, Ralph H. Rack CD36 SURFACE EXPRESSION IN MONOCYTES/ John Snow Inc., Arlington, VA, United States MACROPHAGES Patrice Mimche Nsangou1, Elloise Thompson1, Shereen Nasser1, Hollie 157 Lander1, Miguel Ardid-Candel1, Yvonne Adams1, Donatella Taramelli2, Livia Vivas1 EFFECT OF MICROWAVE FREQUENCY ON THE IN VITRO 1London School of Hygiene and Tropical Medicine, London, United Kingdom, GROWTH OF PLASMODIUM FALCIPARUM 2Department of Public Health Virology and Microbiology, University of Milan, Milan, José A. Stoute1, Jiping Cheng2, Vladimir Torres1, Dinesh Agrawal2, Italy Carmenza Spadafora3 1Pennsylvania State University College of Medicine, Hershey, PA, United States, 151 2Pennsylvania State University College of Engineering, University Park, PA, United States, 3Instituto de Investigaciones y Ciencias Avanzadas y Servicios de Alta Tecnología, MALARIA-INFECTED MICE LIVE UNTIL AT LEAST DAY Ciudad del Saber, Panama 30 AFTER A NEW MONOMERIC TRIOXANE COMBINED (ACMCIP Abstract) WITH MEFLOQUINE ARE ADMINISTERED TOGETHER IN A SINGLE LOW ORAL DOSE Lauren E. Woodard1, Wonsuk Chang1, Xiaochun Chen2, Jun Liu2, Theresa A. Shapiro2, Gary H. Posner1 1Johns Hopkins University, Department of Chemistry, Baltimore, MD, United States, 2Johns Hopkins University, Baltimore, MD, United States

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MALARIA – DRUG DEVELOPMENT 164

METABOLIC STABILITIES AND METABOLITE PROFILES 158 OF ARTESUNIC ACID (AS) AND ARTELINIC ACID (AL) IN CRYOPRESERVED HUMAN HEPATOCYTES PHARMACODYNAMICS OF HYDROXAMATE-BASED HDAC INHIBITORS IN P. FALCIPARUM Qigui Li, Charles Gu, Jing Zhang, Lisa H. Xie, Peter J. Weina Walter Reed Army Institute of Research, Silver Spring, MD, United States Kathy T. Andrews1, Thanh Tran1, Zbyneck Bozdech2, Tina Skinner-Adams3, Andrew Lucke4, Glen Boyle3, David Fairlie4 165 1Griffi th University, Brisbane, Australia, 2Nanyang Technological University, Singapore, Singapore, 3Queensland Institute of Medical Research, Brisbane, Australia, 4University of Queensland, Brisbane, Australia TRIANGULAR TEST DESIGN TO EVALUATE TINIDAZOLE IN THE PREVENTION OF PLASMODIUM VIVAX RELAPSE 159 Louis R. Macareo1, Khin M. Luang2, R. Scott Miller1, Phaik Yeong Cheah3, Prayoon Yuentrakul4, Francois Nosten2 TARGETING PFHSP90 IN PLASMODIUM FALCIPARUM 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2Shoklo Malaria Research Unit, Mae Sot, Thailand, 3Centre for Tropical Medicine, Nuffi eld MALARIA: A STRATEGY TO REVERSE RESISTANCE Department of Clinical Medicine, University of Oxford CCVTM, Oxford, United Dea Shahinas1, Gabriela Chiosis2, Dylan R. Pillai1 Kingdom, 4Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand 1University of Toronto, Toronto, ON, Canada, 2Memorial Sloan Kettering Cancer Center, New York, NY, United States 166 (ACMCIP Abstract) PLASMODIUM FALCIPARUM 160 A NOVEL SERIES OF DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH IN VIVO ANTIMALARIAL ACTIVITY EVALUATION OF A FACS-BASED METHOD USING AUTOFLUORESCENCE AND DNA STAIN YOYO-1 FOR Michael L. Booker1, Cecilia M. Bastos1, Martin L. Kramer1, Joseph Cortese2, 1 3 3 1 PARASITE QUANTIFICATION IN PERIPHERAL BLOOD Cassandra Celatka , Vadiraj Gopinath , Jakir Pinjari , Robert H. Barker , Benito Munoz2, Miryam I. Garcia-Rosa4, Renato Skerlj1 FROM CHILDREN IN RURAL MOZAMBIQUE 1Genzyme Corporation, Waltham, MA, United States, 2Infectious Diseases Initiative, Augusto J. Nhabomba, Joe Campo, Jahit Sacarlal, Maria Belen Jimenez- Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, Diaz, Eusebio Macete, Montse Renom, Inigo Angulo-Barturen, Pedro Alonso, United States, 3Advinus Therapeutics Pvt Ltd, Bangalore, India, 4University of Puerto Carlota Dobano, John Aponte Rico School of Medicine, Department of Microbiology and Medical Zoology, San Juan,

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SIMILAR EMBRYONIC TOXICITY AND COMPARABLE THE DEVELOPMENT, OPTIMIZATION AND VALIDATION PHARMACOKINETICS OF ARTESUNATE FOLLOWING OF A HIGH THROUGHPUT SCREENING ASSAY FOR MULTIPLE INTRAVENOUS AND INTRAMUSCULAR ANTI-MALARIA DRUGS DISCOVERY DOSES IN PREGNANT RATS Pulin Che Qigui Li, Yuanzheng Si, Lisa Xie, Jing Zhang, Peter J. Weina University of Alabama at Birmingham, Birmingham, Alabama, AL, United States Walter Reed Army Institute of Research, Silver Spring, MD, United States 168 162 3D-QSAR MODELS TO PREDICT IN VITRO IDENTIFICATION AND VALIDATION OF THE ANTIMALARIAL EFFICACY AND METHEMOGLOBIN PLASMODIUM CELL-CYCLE IN BLOOD STAGE BY TOXICITY OF 8-AMINOQUINOLINE ANALOGS AND FLOW CYTOMETRY IN COMPARISON TO OPTICAL DERIVATIVES MICROSCOPY Jayendra Bhonsle1, Babu Tekwani2, Aruna Sampath2, Larry Walker2, Colin 1 1 Lisa H. Xie, Jing Zhang, Peter J. Weina, Qigui Li Ohrt , Alan Magill 1 2 Walter Reed Army Institute of Research, Silver Spring, MD, United States Walter Reed Army Institute of Research, Silver Spring, MD, United States, National Center for Natural Products Research, University of Mississippi, University, MS, United 163 States

IMPROVING RELATIVE BIOAVAILABILITY OF ORAL WR299666 BY REDUCING PARTICLE SIZE USING HOMOGENIZER AND ULTRA-SONICATOR Jing Zhang, Lisa H. Xie, Victor Melendez, Qigui Li, Peter J. Weina Walter Reed Army Institute of Research, Silver Spring, MD, United States

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A HIGH-THROUGHPUT IN VITRO SCREEN TO IDENTIFY VARIATIONS IN PFUBP-1, ATPASE-6 AND PFMDR-1 INHIBITORS OF THE PLASMODIUM FALCIPARUM HEAT GENES ENCODING DRUG RESISTANCE FOLLOWING SHOCK PROTEIN 90 BINDING ACTIVITY ARTEMETHER-LUMEFANTRINE TREATMENT IN Martin L. Kramer1, Ralph Mazitschek2, Michael Booker1, Joseph Cortese2, SUDANESE PATIENTS Leila Saxby Ross3, Robert H, Barker, Jr.1, Jon Clardy4, Vishal Patel4, Dyann Nahla B. Gadalla1, Ishag Adam2, Salah Eldin El-Zaki3, Izdihar Mukhtar4, Wirth5 Amal Gadalla3, Sahar Bashir4, David C. Warhurst1, Badria B. El-Sayed3, Colin 1Genzyme Corporation, Waltham, MA, United States, 2Broad Institute of Harvard Sutherland1 and Massachusetts Institute of Technology, Cambridge, MA, United States, 3Harvard 1London School of Hygiene and Tropical Medicine, London, United Kingdom, 2College University, Cambridge, MA, United States, 4Harvard Medical School, Cambridge, MA, of Medicine, University of Khartoum, Khartoum, Sudan, 3Department of Epidemiology, United States, 5Harvard School of Public Health, Cambridge, MA, United States Tropical Medicine Research Institute, Khartoum, Sudan, 4National Health Laboratory, Ministry of Health, Khartoum, Sudan 170 176 LINKING ANTI-PLASMODIUM COMPOUNDS TO THEIR PROTEIN TARGETS VIA HIGH-THROUGHPUT ENZYME COMMON ORIGIN OF CHLOROQUINE RESISTANT ACTIVITY ASSAYS PLASMODIUM FALCIPARUM AND SUBSEQUENT POINT Gregory J. Crowther1, Alberto J. Napuli1, Eleanor F. Dagostino2, James MUTATIONS IN PFCRT1 GENE ASSOCIATED WITH H. Gilligan2, Justin B. Stockmyer2, Carolyn Francek2, Yu Wang2, Philip P. CHLOROQUINE RESISTANCE IN SOUTHERN PAKISTAN 1 1 1 1 Rodenbough , Andrew P. Thomas , Kuzma V. Kovzun , Lisa J. Castaneda , 1 1 1 1 1 1 2 Wasiq F. Rawasia , Mohammed Asim Beg , Najia Ghanchi , Sankar David J. Leibly , Janhavi Bhandari , Michael H. Gelb , Arnab K. Chatterjee , 2 2 2 2 1 2 Sridaran , Venkatachalam Udhayakumar Achim Brinker , Richard J. Glynne , Wesley C. Van Voorhis , Kelli L. Kuhen 1The Aga Khan University, Karachi, Pakistan, 2Centers for Disease Control and 1 2 University of Washington, Seattle, WA, United States, Genomics Institute of the Prevention, Atlanta, GA, United States Novartis Research Foundation (GNF), San Diego, CA, United States (ACMCIP Abstract) 177

MALARIA – DRUG RESISTANCE LACK OF P. FALCIPARUM MULTIDRUG RESISTANCE GENES (PFMDR) AMPLIFICATIONS IN PAKISTANI 171 ISOLATES Najia K. Ghanchi1, M. A. Beg1, J. Ursing2, S. Jafri1, A. Martensson2 DETECTION OF IN VIVO CHLOROQUINE RESISTANCE IN 1Aga Khan University, Karachi, Pakistan, 2Karolinska Institute, Stockholm, Sweden PLASMODIUM FALCIPARUM IN CHENNAI, INDIA 178 Alex Eapen1, John Ravindran1, Hema Joshi2, Aditya Prasad Dash3 1National Institute of Malaria Research, Indian Council of Medical Research, Chennai, India, 2National Institute of Malaria Research, Indian Council of Medical Research, NO PFMDR1 AMPLIFICATION IN PLASMODIUM Delhi, India, 3World Health Organization (SEARO), New Delhi, India FALCIPARUM FROM THE PACIFIC COAST OF COLOMBIA WITH VARYING MEFLOQUINE SUSCEPTIBILITY 172 Claribel Murillo Solano1, Christin Sisowath2, Anders Björkman2, José Pedro Gil2, Lyda Osorio1 IN VITRO MALIAN PLASMODIUM FALCIPARUM 1Centro Internacional de Entrenamiento e Investigaciones Médicas, Cali, Colombia, SUSCEPTIBILITY TO ARTEMISININ AND PREVALENCE 2Malaria Research Unit, Department of Infectious Diseases, Division of Medicine, OF PFATP6 S769N MUTATION Karolinska Institutet, Stockholm, Sweden Souleymane Dama, Bakary Fofana, Aly Kodio, Demba Dembele, Sekou 179 Toure, Bakary Sidibe, Ogobara Doumbo, Abdoulaye Djimde Malaria Research and Training Center, Bamako, Mali PLASMODIUM FALCIPARUM W2 AS A STANDARD 173 LABORATORY CLONE FOR HRP2 (HISTIDINE-RICH PROTEIN 2)-ELISA BASED DRUG SENSITIVITY ASSAY A MOUSE-SCREENING MODEL FOR RESISTANT Wiriya Rutvisuttinunt, Stuart D. Tyner, Kritsanai Yingyern, Panjaporn PLASMODIUM FALCIPARUM DHFR-TS INHIBITORS Chaichana, Mark M. Fukuda, Kurt E. Schaecher Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand Mofolusho Falade, Chairat Uthaipibull, Yongyuth Yuthavong, Sumalee Kamchonwongpaisan National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathumthani, 180 Thailand, Thailand MIXED MALARIA FICTION OR REALISM? 174 Ana C. Giraldo Universidad de Antioquia, Medellin, Colombia ARTEMISININ-BASED COMBINATION THERAPY (ACT) DRUG RESISTANCE TRENDS IN PLASMODIUM FALCIPARUM ISOLATES IN SOUTHEAST ASIA Jessica L. Schilke The University of South Florida, Tampa, FL, United States

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CHANGING PATTERN OF CHLOROQUINE- EFFECTS OF A LOW-INFECTIVITY RESERVOIR IN SUSCEPTIBILITY OF PLASMODIUM VIVAX IN THE MALARIA ENDEMIC POPULATIONS ON TRANSMISSION REPUBLIC OF KOREA AND LONG TERM CONTROL Jae-Won Park1, Gyo Jun1, Joon-Sup Yeom2, Hyeong-Seok Lim3 Stephan Karl1, Peter A. Zimmerman2, Tim G. St.-Pierre1, David Gurarie2 1Graduate School of Medicine, Gachon University of Medicine and Science, Incheon, 1The University of Western Australia, Perth, Australia, 2Case Western Reserve Republic of Korea, 2Kangbuk Samsung Hospital, Sungkyunkwan University School University, Cleveland, OH, United States of Medicine, Seoul, Republic of Korea, 3Ulsan University College of Medicine, Seoul, Republic of Korea 187

182 ARE FISH FARMING ACTIVITIES CONTRIBUTING TO MALARIA TRANSMISSION IN THE PERUVIAN AMAZON? COMPARATIVE STUDY OF PLASMODIUM FALCIPARUM Mathieu Maheu-Giroux1, Martin Casapia2, Veronica E. Soto-Calle3, Lea GROWTH IN SERUM-FREE MEDIA AND EXPRESSION Berrang Ford1, David L. Buckeridge1, Oliver T. Coomes1, Theresa W. LEVELS OF PFCRT GENE AFTER EXPOSURE TO DRUG Gyorkos1 Bethel Kwansa-Bentum1, Kei Kitamura1, William K. Anyan1, Takashi 1McGill University, Montréal, QC, Canada, 2Asociación Civil Selva Amazonica, Iquitos, Kumagai1, Shinji Izumiyama2, Hiroko Asahi2, Michael D. Wilson3, Nobuo Peru, 3Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium Ohta1 1Tokyo Medical and Dental University, Tokyo, Japan, 2National Institute of Infectious 188 Diseases, Tokyo, Japan, 3Noguchi Memorial Institute for Medical Research, Accra, Ghana ARE RDTS COST-EFFECTIVE AND SAFE? A SYSTEMATIC (ACMCIP Abstract) REVIEW OF ACCURACY IN MALARIA DIAGNOSIS 183 M. S. Newman, Latha Rajan Tulane University, New Orleans, LA, United States

PREVALENCE OF MUTATIONS IN PFCRT, PFDHFR AND 189 PFDHFR GENES CONFERRING DRUG RESISTANCE IN P. FALCIPARUM MALARIA ISOLATES FROM SOUTHERN DETERMINANTS OF USE OF MALARIA PREVENTION PAKISTAN STRATEGIES DURING PREGNANCY IN UGANDA 1 1 2 1 Mohammad A. Beg , Najia K. Ghanchi , Johan Ursing , Sana Jafri , Andreas 1 1 2 3 Laura Sangare , Noel Weiss , Sarah Staedke , Steven Kiwuwa , Diane Thursday, November 19 Martensson2 Martin1, Thomas Lumley1, Andreas Stergachis1 1Aga Khan University, Karachi, Pakistan, 2Karolinska Institute, Stockholm, Sweden 1University of Washington, Seattle, WA, United States, 2London School of Hygiene and Tropical Medicine, London, United Kingdom, 3Makerere University, Kampala, Uganda MALARIA - EPIDEMIOLOGY 190

184 RISK MAPPING TO SUPPORT MALARIA ELIMINATION IN VANUATU CAN THE SPATIAL DISTRIBUTION OF DUFFY 1 1 1 2 NEGATIVITY EXPLAIN PLASMODIUM VIVAX ABSENCE IN Heidi Reid , Archie Clements , Andrew Vallely , George Taleo 1University of Queensland, Brisbane, Australia, 2National Vector Borne Disease Control AFRICA? Program, Port Vila, Vanuatu Rosalind E. Howes, Fred B. Piel, Carlos A. Guerra, Peter W. Gething, Anand P. Patil, Simon I. Hay 191 Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom SEQUENCE POLYMORPHISMS OF THE P. FALCIPARUM 185 MEROZOITE SURFACE PROTEIN-2 (MSP-2) REVEAL A HIGHER COMPLEXITY OF INFECTION IN MALARIA- SPATIAL PREDICTION OF PLASMODIUM FALCIPARUM INFECTED CHILDREN PREVALENCE IN INDONESIA IN 2008 Segun I. Oyedeji1, Henrietta O. Awobode2, Jürgen F. Kun3 1Bells University of Technology, Ota, Ogun State, Nigeria, 2University of Ibadan, 1 2 3 3 Iqbal Elyazar , Hanifah Rogayah , Pete Gething , Anand Patil , Carlos Ibadan, Nigeria, 3Institute of Tropical Medicine, Tübingen, Germany 3 2 4 3 1 Guerra , Desak Wismarini , Rita Kusriastuti , Simon Hay , Kevin Baird (ACMCIP Abstract) 1Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, 2National Communicable Disease Center, Sub-directorate of Malaria, Ministry of Health, Jakarta, Indonesia, 192 3Spatial Ecology and Epidemiology Group, Tinbergen Building, Department of Zoology, University of Oxford, Oxford, United Kingdom, 4National Communicable Disease Center, Ministry of Health, Jakarta, Indonesia THE CHANGING PATTERNS OF MALARIA ADMISSIONS SINCE 1999 AT 18 HOSPITALS ACROSS KENYA Emelda A. Okiro, Julliette Mutheu, Pete W. Gething, Elizabeth Juma, Robert W. Snow Kenya Medical Research Institute-Wellcome Trust Research Programme, Nairobi, Kenya

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EXPRESSION OF RECOMBINANT PROTEINS FROM THE EFFECT OF TRANSMISSION INTENSITY AND AGE TROPHOZOITES AND MEROZOITES OF PLASMODIUM ON SUBCLASS ANTIBODY RESPONSES TO PLASMODIUM FALCIPARUM ISOLATES FROM BRAZILIAN AMAZON AND FALCIPARUM ANTIGENS IMMUNE RESPONSE ANALYSIS Gregory S. Noland1, John M. Vulule2, James W. Kazura3, Ann M. Márcia M. Medeiros, Catarina Castineiras, Gerhard Wunderlich Moormann3, Xinan M. Min1, Chandy C. John1 University of Sao Paulo, São Paulo, Brazil 1University of Minnesota Medical School, Minneapolis, MN, United States, 2Kenya Medical Research Institute, Center for Global Health Research, Kisumu, Kenya, 3Case 194 Western Reserve University, Cleveland, OH, United States 200 MALARIA RELATED WITH SOCIAL CHARACTERISTICS, SYMPTOMS AND PARASITE DENSITY, TIERRALTA, PLASMODIUM VIVAX AMA-1 PLAYS AN IMPORTANT CORDOBA, COLOMBIA ROLE IN ADAPTIVE IMMUNE RESPONSE ELICITING 1 1 1 1 Maria F. Yasnot , Yicel Alvarez , Maria Angelica Ramos , Villa Keny , DIFFERENTIATION OF DENDRITIC CELLS Gustavo Enrique Quintero2 1Universidad de Cordoba, Monteria, Colombia, 2Grupo de Investigaciones Microbiologicas Erika M. Braga1, Lilian L. Bueno1, Ricardo T. Fujiwara1, Cristiane G. y Biomedicas de Córdoba, Monteria, Colombia Morais1, Oscar Bruna-Romero1, Erica M. Bouillet1, Irene S. Soares2, Cor Jesus F. Fontes3 195 1Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, 2Universidade de São Paulo, São Paulo, Brazil, 3Universidade Federal de Mato Grosso, Cuiabá, Brazil (ACMCIP Abstract) TOWARD MALARIA EARLY WARNING IN AFGHANISTAN USING REMOTE SENSING 201 Richard Kiang1, Najibullah Safi 2, Farida Adimi1, Radina Soebiyanto1 1NASA Goddard Space Flight Center, Greenbelt, MD, United States, 2National Malaria ERYTHROCYTE CR1/CD35 INHIBITS TNF-α and Leishmaniasis Control Program, Ministry of Public Health, Kabul, Afghanistan PRODUCTION BY RESTRICTING IMMUNE COMPLEX 196 UPTAKE BY MACROPHAGES Michael M. Odera1, Jose A. Stoute2 1Kenya Medical Research Institute, Kisumu, Kenya, 2Department of Medicine, Penn IS FEVER A GOOD SCREENING TEST FOR MALARIA State University College of Medicine, Hershey, PA, United States SURVEYS IN MELANESIA? (ACMCIP Abstract) G. Dennis Shanks Australian Army Malaria Institute, Enoggera, Australia 202

MALARIA - IMMUNOLOGY EXPRESSION OF FCγRIII BY MONOCYTES FROM CHILDREN WITH PLASMODIUM FALCIPARUM MALARIA: ASSOCIATION WITH SEVERE MALARIAL ANAEMIA 197 Lilian A. Ogonda1, Alloys S. Orago2, Michael F. Otieno2, Jose A. Stoute3 1Kenya Medical Research Institute (KEMRI)/Walter Reed Project (WRP), Kisumu, INFLUENCE OF ABO BLOOD GROUP PHENOTYPES Kenya, 2Kenyatta University, Nairobi, Kenya, 3Pennsylvania State University College of ON PARITY SPECIFIC IMMUNITY TO PLASMODIUM Medicine, Hersey, PA, United States FALCIPARUM MALARIA AMONG WOMEN IN PARTS OF (ACMCIP Abstract) THE IMO RIVER BASIN, NIGERIA Uchechukwu M. Chukwuocha, Ikechukwu N. Dozie, Celestine O. Onwuliri, 203 Okechukwu C. Aguwa Federal University of Technology, Owerri ,Nigeria IFN-γ RESPONSES TO PLASMODIUM FALCIPARUM (ACMCIP Abstract) ANTIGENS IN AREAS OF UNSTABLE TRANSMISSION DECREASE IN PERIODS OF VERY LOW OR ABSENT 198 TRANSMISSION Bilha S. Ogola1, Gregory S. Noland2, Ng’wena G. Magak3, Cyrus Ayieko4, ENDEMIC BURKITT LYMPHOMA IS NOT John M. Vulule5, Chandy C. John2 ASSOCIATED WITH COMMON SINGLE NUCLEOTIDE 1Moi University, Department of Biological Sciences, School of Science, Eldoret, Kenya, POLYMORPHISMS IN TOLL-LIKE RECEPTORS 4 OR 9 2University of Minnesota Medical School, Minneapolis, MN, United States, 3Moi University, School of Medicine, Eldoret, Kenya, 4Maseno University, Department of David H. Mulama 5 Kenya Medical Research Institute, Kisumu, Kenya Zoology, Faculty of Science, Maseno, Kenya, Kenya Medical Research Institute, Center (ACMCIP Abstract) for Global Health Research, Kisumu, Kenya (ACMCIP Abstract)

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CYTOKINE RESPONSE TO PLASMODIUM FALCIPARUM TRANSGENIC MODEL FOR ANTI-P. VIVAX MULTISTAGE ANTIGEN (MB2) IN ADULTS LIVING DIHYDROFOLATE REDUCTASE-THYMIDYLATE IN AREAS OF VARYING MALARIA TRANSMISSION IN SYNTHASE SCREENING WESTERN KENYA Voravuth Somsak1, Chairat Uthaipibull2, S. Srichairatanakool1, Y. Gideon M. Ng’wena1, Lyticia V. Ochola2, Gregory S. Noland3, Anthony A. Yuthavong2, S. Kamchonwongpaisan2 James4, Ayub V. Ofulla2, Vulule M. John5, Chandy C. John3 Chiang Mai University, Chiang Mai, Thailand, National Center for Genetic Engineering 1Moi University School Of Medicine, Eldoret, Kenya, 2Maseno University, Kisumu, and Biotechnology (BIOTEC), National Science and Technology Development Agency Kenya, 3Minnesota Medical School, Minneapolis, MN, United States, 4Department of (NSTDA), Pathumthani, Thailand Molecular Biochemistry, Irvine, CA, United States, 5Kenya Medical Research Institute, (ACMCIP Abstract) Kisumu, Kenya (ACMCIP Abstract) 210

205 STUDIES ON ABO BLOOD GROUPS, HAEMOGLOBINOPATHIES AND G6PD GENOTYPES, AND HUMAN BLOOD MONOCYTE PHENOTYPE AND PLASMODIUM FALCIPARUM INFECTION IN KPONE-ON- FUNCTION DURING ACUTE UNCOMPLICATED MALARIA SEA, GHANA ATTACK Samuel Armoo Pattamawan Chimma1, Christian Roussilhon1, Panudda Sratongno2, Kovit Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana Pattanapanyasat2, Jean-Louis Pérignon1, David Roberts3, Pierre Druilhe1 (ACMCIP Abstract) 1Institut Pasteur, Paris, France, 2Mahidol University, Bangkok, Thailand, 3Oxford University, Oxford, United Kingdom 211 (ACMCIP Abstract) RESISTANCE-MEDIATING POLYMORPHISMS OF 206 PLASMODIUM FALCIPARUM AMONG SEVERE MALARIA PATIENTS PRESENTING TO THE KOMFO ANOKYE HOST GENOTYPE FOR DUFFY ANTIGEN RECEPTOR TEACHING HOSPITAL, KUMASI, GHANA CHEMOKINE (DARC) MODIFIES ACQUISITION OF 1 2 3 IMMUNE RESPONSE TO PLASMODIUM VIVAX Harry H. Abruquah , Jennifer Evans , Daniella Tominsky , Christa Flessner3, Florian Marks3, Juergen May3, Sammy C. Tay4, Edward T. Amanda Maestre1, Carlos Muskus2, Victoria Duque2, Olga Agudelo1, Akihide Agbenyega4, Rolf Hotsmann3 Thursday, November 19 Takagi3, Kim Lee Sim4, Stephen L. Hoffman5, Sope Olugbile3, Ivan D. Velez2, 1University Hospital, Kumasi, Ghana, 2KCCR, Kumasi, Ghana, 3BNI, Hamburg, Ruobing Wang3 Germany, 4School of Medical Sciences, Kumasi, Ghana 1Grupo Salud y Comunidad, Universidad de Antioquia, Medellin, Colombia, 2Programa (ACMCIP Abstract) de Estudio y Control de Enfermedades Tropicales PECET, Universidad de Antioquia, Medellin, Colombia, 3Seattle Biomedical Research Institute, Seattle, WA, United States, 212 4Protein Potential, Rockville, MD, United States, 5Sanaria, Rockville, MD, United States (ACMCIP Abstract) REGULATORY MECHANISMS OF GENE EXPRESSION IN INTRAERYTHROCYTIC CELL CYCLE OF PLASMODIUM MALARIA – MOLECULAR BIOLOGY FALCIPARUM Kanako Komaki-Yasuda1, Mitsuru Okuwaki2, Kyosuke Nagata2, Shin-ichiro 207 Kawazu3, Shigeyuki Kano1 1Research Institute, International Medical Center of Japan, Tokyo, Japan, 2Graduate EPSTEIN BARR VIRAL LOAD AND ANTIBODIES IN School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan, 3National Research Center for Protozoan CHILDREN WITH MALARIA Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan Moses Y. Otiende Walter Reed Project/United States Army Medical Research Unit-Kenya, Kisumu, Kenya 213 (ACMCIP Abstract) ANALYSIS OF PFE0565W AND PF11_0394, TWO 208 PLASMODIUM FALCIPARUM GENES

1 1 2 1 THE EFFECTIVENESS OF SULFADOXINE - Maggie Schlarman , Michael Kariuki , Alexis LaCrue , Renee Roberts , Ruguang Ou1, Brenda Beerntsen1 PYRIMETHAMINE-BASED COMBINATION THERAPY 1University of Missouri, Columbia, MO, United States, 2University of South Florida, VERSUS SULFADOXINE - PYRIMETHAMINE ALONE Tampa, FL, United States AGAINST UNCOMPLICATED PLASMODIUM FALCIPARUM INFECTIONS Zoumana I. Traore, Cheick Papa Sangare, Abdoul Habib Beavogui Ah, Hamma Maiga, Mamadou Tekete, Dinkorma Ouologuem, Antoine Dara, Christelle N’Dong, Oumar Bila Traore, Abdoulaye Djimde, Ogobara K. Doumbo Malaria Research and Training Center, Bamako, Mali

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FUNCTIONAL CHARACTERIZATION OF PLASMODIUM QUICK AND SIMPLE DIAGNOSTIC METHOD FOR OVALE DIHYDROFOLATE REDUCTASE-THYMIDYLATE THE IDENTIFICATION OF ANOPHELES GAMBIAE AND SYNTHASE ANOPHELES ARABIENSIS MOSQUITOES BASED ON THE Srisuda Tirakarn1, Ubolsree Leartsakulpanich2, Palangpon Kongsaeree1, LOOP-MEDIATED ISOTHERMAL PCR (LAMP) Yongyuth Yuthawong2 Mariangela Bonizzoni1, Yaw Afrane2, Anne Vardo-Zalik1, Guiyun Yan1 1Department of Chemistry and Center for Excellence in Protein Structure and Function, 1University of California Irvine, Irvine, CA, United States, 2Center for Vector Biology and Faculty of Science, Mahidol University, Bangkok, Thailand, 2National Center for Genetic Control, Kisumu, Kenya Engineering and Biotechnology, National Science and Technology Development Agency, Thailand Science Park, Paholyothin Rd, Pathumthani, Thailand 221 (ACMCIP Abstract)

215 COMBINING INDOOR RESIDUAL SPRAYING AND INSECTICIDE TREATED NET INTERVENTIONS FUNCTIONAL CHARACTERISATION OF THE Immo Kleinschmidt1, Christopher Schwabe2, Murugasampillay Shiva3, Jose 2 4 5 6 PLASMODIUM CENTROMERE AND GENERATION OF A Luis Segura , Victor Sima , Samuel J. Mabunda , Michael Coleman 1London School of Hygiene and Tropical Medicine, London, United Kingdom, 2Medical PLASMODIUM ARTIFICIAL CHROMOSOME Care Development International, Silver Spring, MD, United States, 3World Health Shiroh Iwanaga1, Masao Yuda1, Izumi Kaneko1, Chris J. Janse2, Andrew P. Organisation, Geneva, Switzerland, 4Ministerio de Sanidad y Bienestar Social, Malabo, Waters3 Equatorial Guinea, 5Ministerio da Saude, Maputo, Mozambique, 6Liverpool School of 1Mie University, Tsu, Japan, 2Leiden University Medical Center, Leiden, The Tropical Medicine, Liverpool, United Kingdom Netherlands, 3University of Glasgow, Glasgow, United Kingdom 222 216 LONG-LASTING INSECTICIDAL MOSQUITO NET USAGE LOCALIZATION OF SERINE IN EASTERN SIERRA LEONE - THE SUCCESS OF FREE HYDROXYMETHYLTRANSFERASE ISOFORMS IN DISTRIBUTION PLASMODIUM FALCIPARUM Sibylle Gerstl1, Sophie Dunkley2, Ahmed Mukhtar2, Peter Maes3, Martin De Wichai Pornthanakasem, Ubolsree Leartsakulpanich, Chairat Uthaipibull, Smet3, Samuel Baker4, Jacob Maikere3 Darin Kongkasuriyachai, Yongyuth Yuthavong 1Médecins Sans Frontières UK, London, United Kingdom, 2Médecins Sans Frontières National Center for Genetic Engineering and Biotechnology, Pathumthani, Thailand Brussels, Bo, Sierra Leone, 3Médecins Sans Frontières Brussels, Brussels, Belgium, (ACMCIP Abstract) 4Ministry of Health and Sanitation, Freetown, Sierra Leone

MALARIA/MOSQUITOES – PREVENTION 223 OF TRANSMISSION A NEW ANTI-MOSQUITO INSECTICIDE PAINT: EVALUATION OF ITS FIELD EFFICACY AGAINST 217 ANOPHELES GAMBIAE AND CULEX QUINQUEFASCIATUS OVER 12 MONTHS KNOWLEDGE, ATTITUDES AND PRACTICES OF Beatriz Mosqueira1, J. Chabi2, Fabrice Chandre2, Martin Akogbeto3, Jean- MOTHERS ON THE USE OF INSECTICIDE-TREATED Marc Hougard3, Pierre Carnevale2, Santiago Mas-Coma1 NETS IN THE PREVENTION OF CHILDHOOD MALARIA 1Departamento de Parasitologia, Universidad de Valencia, Burjassot - Valencia, Spain, 2 3 IN A CHILD-IMMUNIZATION CLINIC IN SOUTHEASTERN UR016, Institut de Recherche pour le Developpement, Montpellier, France, Centre de Recherche Entomologique de Cotonou, Cotonou, Benin NIGERIA Kenechukwu O. Chudy-Onwugaje 224 Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria PHARMACOKINETICS (PK) AND PHARMACODYNAMICS 218 (PD) AND SAFETY OF ARTESUNATE (AS) AND DIHYDROARTEMISININ (DHA) FOLLOWING A SINGLE ANTIMALARIAL MEDIATED MODULATION ORAL DOSE OF ARTESUNATE DURING THE SECOND OF MELANIZATION AND INVOLVEMENT OF AND THIRD TRIMESTER OF PREGNANCY PROPHENOLOXIDASE IN THE SUPPRESSION OF 1 1 1 2 PLASMODIUM DEVELOPMENT IN ANOPHELES Marie A. Onyamboko , Jef Atibu , Vicky Lokomba , Steven Meshnick , Macaya Douoguih3, Jennifer Hemingway-Foday4, Matthew Koch4, David Fusheng Huang, Jian Zhang, Ying Wang Wesche5, Edmund Capparelli6, Larry Fleckenstein7, Robert Ryder6, Carl Third Military Medical University, Chongqing, China Bose2, Linda Wright8, Antoinette Tshefu1 (ACMCIP Abstract) 1Kinshasa School of Public Health, Kinshasa, The Democratic Republic of the Congo, 2University of North Carolina, Chapel Hill, NC, United States, 3Aeras Global TB 219 Vaccine Foundation, Rockville, MD, United States, 4RTI International, Research Triangle Park, NC, United States, 5Lundbeck, Inc, Deerfi eld, IL, United States, 100 MILLION USED LONG-LASTING INSECTICIDE- 6University of California, San Diego, San Diego, CA, United States, 7University of 8 TREATED NETS (LNS): HOW DO WE AVERT A Iowa, Iowa City, IA, United States, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States POTENTIAL ENVIRONMENTAL CRISIS IN AFRICA? Ralph H. Rack, Lisa Hare, Stephanie Guillaneux John Snow Inc., Arlington, VA, United States

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IMPACT OF BEDNET USE, INTERMITTENT PREVENTIVE HUMAN INSULIN INGESTED BY ANOPHELES STEPHENSI TREATMENT (IPT), AND ANTENATAL CARE (ANC) MOSQUITO SIGNALS IN THE MIDGUT TO INCREASE DURING PREGNANCY ON THE HEALTH OF NEWBORNS OXIDATIVE DAMAGE AND REDUCE LIFESPAN IN THE KASSENA NANKANA DISTRICT OF NORTHERN Nazzy Pakpour, Laura Dickson, Kong Cheung, Shirley Luckhart GHANA University of California Davis, Davis, CA, United States David J. Fryauff1, Frank Atuguba2, Kwadwo A. Koram3, Thomas (ACMCIP Abstract) Anyorigiya2, Martin Adjuik2, Abraham R. Oduro2, Patrick Ansah2, Abraham Hodgson2, Lucas Amenga Etego2, Francis Nkrumah3 231 1Naval Medical Research Center, Silver Spring, MD, United States, 2Navrongo Health Research Center, Navrongo, Ghana, 3Noguchi Memorial Institute of Medical Research, USING ENHANCED REPRODUCTION AS A NOVEL Accra, Ghana DRIVE MECHANISM FOR MOSQUITO POPULATION REPLACEMENT 226 Anam Javed1, Jason L. Rasgon2, Kendra M. Quicke1, Michael A. Riehle1 1University of Arizona, Tucson, AZ, United States, 2Johns Hopkins University, FACTORS AFFECTING MALARIA PREVENTION AND Baltimore, MD, United States TREATMENT DECISIONS FOR CHILDREN IN THE DEMOCRATIC REPUBLIC OF CONGO 232 Olufunke A. Alaba1, Gauthier Tshiswaka Kashalala1, Adefolarin A. Fawole2 1University of Pretoria, Pretoria, South Africa, 2CentaMed Practitioners, Pretoria, South FUNCTIONAL ANALYSIS OF TAK1 AND IAP2 IN THE Africa YELLOW FEVER MOSQUITO, AEDES AEGYPTI 227 Shin-Hong Shiao National Taiwan University, Taipei, Taiwan

EFFICACY AND WASH RESISTANCE OF ALPHA- 233 CYPERMETHRIN WHO RECOMMENDED LONG LASTING INSECTICIDE NET AGAINST ANOPHELES DARLINGI IN WEST NILE VIRUS INFECTION ALTERS MIDGUT GENE THE PERUVIAN AMAZON EXPRESSION IN CULEX PIPIENS QUINQUEFASCIATUS SAY Elvira Zamora1, Daniel Del Cuadro1, Hugo Rodriguez2, Gregor J. Devine3, (DIPTERA: CULICIDAE) 1 2

Yuri Alegre , Angel Rosas Thursday, November 19 Chelsea T. Smartt1, Stephanie L. Richards1, Sheri L. Anderson1, Jennifer S. 1Regional Direction of Health Loreto, Iquitos, Peru, 2Multi-Country Malaria Project Erickson2 PAMAFRO - Organismo Andino de Salud - Convenio Hipolito Unanue, Lima, Peru, 1University of Florida, Vero Beach, FL, United States, 2McMaster University, Hamilton, 3Rothamsted Research, Harpenden, United Kingdom ON, Canada

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ACCEPTABILITY AND INITIAL USE OF LONG-LASTING ESTABLISHMENT OF AND EVALUATION ON A INSECTICIDE NETS (LLIN) AS MEASURE TO PREVENT STABLY EXPRESSING AND KNOCKDOWN SYSTEM IN AND CONTROL MALARIA IN COLOMBIAN BORDER MOSQUITO CELL LINES AREAS Chao-Fu Yang, Wei-June Chen Edison Soto, Andres Cuervo, Angel Rosas, Daniel Vargas, Lina Florez, Luis Chan Gung University, Tao-Yuan, Taiwan Valera Multi-Country Malaria Project PAMAFRO - Organismo Andino de Salud - Convenio 235 Hipolito Unanue, Lima, Peru MOSQUITO TRANSCRIPTOME CHANGES AND FILARIAL MOSQUITOES – BIOCHEMISTRY AND WORM SUSCEPTIBILITY IN ARMIGERES SUBALBATUS MOLECULAR BIOLOGY Matthew T. Aliota, Jeremy F. Fuchs, Thomas A. Rocheleau, Bruce M. Christensen University of Wisconsin, Madison, WI, United States 229 236 THE IMPACT OF ANTIMICROBIAL PEPTIDE KNOCK DOWN BY RNA INTERFERENCE ON LONGEVITY AND A SHUT-DOWN IN EXPRESSION OF CATALASE REPRODUCTIVE OUTPUT IN AEDES AEGYPTI INCREASES OVARIAN APOPTOSIS DURING THE Raul Ursic Bedoya, Courtney McKay, Carl Lowenberger OVERWINTERING DIAPAUSE OF THE MOSQUITO CULEX Simon Fraser University, Burnaby, BC, Canada PIPIENS Cheolho Sim, Denlinger L. David Department of Entomology, The Ohio State University, Columbus, OH, United States

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HOW DOES PLASMODIUM FALCIPARUM EVADE OF THE LARVAL TEMPERATURE AND NUTRITION ALTER THE MOSQUITO IMMUNE SYSTEM SUSCEPTIBILITY OF AEDES AEGYPTI MOSQUITOES TO Alvaro Molina-Cruz, Corrie Ortega, Jared Winikor, Janneth Rodrigues, CHIKUNGUNYA VIRUS Carolina Barillas-Mury Catherine J. Westbrook, L. Philip Lounibos National Institutes of Health, Bethesda, MD, United States Florida Medical Entomology Laboratory, Department of Entomology and Nematology, University of Florida, Vero Beach, FL, United States 238 244 COMPARISON OF IMMUNOGENIC PROTEINS TO SALIVA OF ANOPHELES ALBIMANUS, ANOPHELES STEPHENSI AND INSECTARY MAINTENANCE OF ASIAN MALARIA AEDES AEGYPTI IN SERUM FROM INDIVIDUALS LIVING VECTORS: AN EVALUATION OF THE EFFECTS OF IN AREAS WHERE THESE SPECIES ARE OR ARE NOT BLOODMEAL SOURCE ON FEEDING, MORTALITY, ENDEMIC FECUNDITY AND EGG HATCHING RATES Berlin L. Londono1, Daisy Carvajal2, Diva Palacios3, Chad Massey1, Joseph Siriporn Phasomkusolsil Keating1, Thomas Eisele1, Mark James1, Don Krogstad1, Dawn Wesson1 Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand 1Tulane University, New Orleans, LA, United States, 2Universidad de Pamplona, Pamplona, Colombia, 3Hospital San Francisco de Asis, Quibdo, Colombia 245

239 VARIATION IN CIBARIAL ARMATURE OF TWO MEMBERS OF THE ANOPHELES GAMBIAE S.L. EXHIBITING THE ROLE OF SLC7-TYPE AMINO ACID TRANSPORTERS DIFFERENT CAPACITIES IN LYMPHATIC FILARIASIS IN MOSQUITO IMMUNITY, REPRODUCTION AND TRANSMISSION LIFESPAN Hilaria Amuzu, Michael D. Wilson, Daniel A. Boakye Lisa L. Drake, Sarah Aguirre, Immo A. Hansen Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana NMSU, Las Cruces, NM, United States 246 240 BED NET COVERAGE, USAGE AND CONDITION IN AN EVOLUTIONARY CONSERVED FUNCTION OF THE FISHING VILLAGES OF SUBA DISTRICT, WESTERN JAK-STAT PATHWAY IN ANTI-DENGUE DEFENSES KENYA Jayme A. Souza-Neto, George Dimopoulos Gabriel O. Dida1, George O. Sonye2, H. Horio3, S. Kaneko3, M. Shimada3, F. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States Kyoko3, N. Minakawa3 1School of Public Health, Maseno University, Kisumu, Kenya, 2International Centre of 241 Insect Physiology and Ecology, Mbita, Kenya, 3Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan EFFECT OF AEDES AEGYPTI SALIVA ON MACROPHAGE CYTOKINE EXPRESSION AND ON DENGUE INFECTION 247 Karine Delroux SRI International, Center for Advanced Drug Research (CADRE), Harrisonburg, VA, COMPARATIVE EVALUATION OF THE EFFECTIVENESS United States OF THE IFAKARA TENT TRAP, STANDARDIZED (ACMCIP Abstract) RESTING BOXES AND THE HUMAN LANDING CATCH FOR SAMPLING MALARIA VECTORS AND OTHER MOSQUITOES – VECTOR BIOLOGY- MOSQUITOES IN URBAN DAR ES SALAAM EPIDEMIOLOGY Maggy Sikulu University of Nairobi, Nairobi, Kenya

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ACCEPTANCE AND WILLINGNESS-TO-PAY OF A NOVEL IPTP USE AMONG PREGNANT WOMEN ATTENDING “PUSH-PULL” STRATEGY FOR AEDES AEGYPTI VECTOR ANTENATAL CLINICS IN PRIMARY HEALTH CARE CONTROL IN CENTRAL THAILAND CENTERS IN A RURAL LOCAL GOVERNMENT AREA IN Valaikanya Plasai1, Theeraphap Charoenviriyaphap2, John Grieco2, Nicole NIGERIA Achee2 1 Stella O. Akinleye Bureau of Vector-Borne Diseases, Ministry of Public Health, Nonthaburi, Thailand, University of Ibadan, Ibadan, Oyo State, Nigeria 2Uniformed Services University of the Health Sciences, Bethesda, MD, United States

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ECOLOGICAL CHARACTERIZATION OF ANOPHELES BIOLOGICAL DIVERSITY AND GENE POLYMORPHISMS LARVAL HABITATS AND THEIR DISTRIBUTION IN ASSOCIATED WITH KNOCKDOWN RESISTANCE IN WESTERN KENYA HIGHLANDS MEMBERS OF THE PAPUA NEW GUINEA ANOPHELES Bryson A. Ndenga1, Jemimah A. Simbauni2, Jenard Mbugi2, Andrew K. PUNCTULATUS SPECIES COMPLEX Githeko1, Ulrike Fillinger3 Cara N. Henry-Halldin1, Kogulan Nadesakumaran1, Daphne Sepe2, John 1Kenya Medical Research Institute, Kisumu, Kenya, 2Kenyatta University, Nairobi, B. Keven2, Laurie Gray1, Lisa Reimer1, Nigel W. Beebe3, Robert D. Cooper4, Kenya, 3University of Durham, Durham, United Kingdom Peter A. Zimmerman1 1Case Western Reserve University, Cleveland, OH, United States, 2Papua New Guinea 250 Institute of Medical Research, Madang, Papua New Guinea, 3School of Integrative Biology, University of Queensland, St. Lucia, Australia, 4Australian Army Malaria TRAPPING MALARIA VECTORS USING SYNTHETIC Institute, Enoggera, Australia ODORS THAT ARE MORE ATTRACTIVE THAN HUMANS 256 Fredros O. Okumu Ifakara Health Institute, Ifakara, Morogoro region, United Republic of Tanzania XENOMONITORING FOR ZOONOTIC FILARIASIS IN 251 NORTH DAKOTA Joseph O. Mehus, Jeffery A. Bell, Jefferson A. Vaughan TARGETING PRODUCTIVE CONTAINER AND POSITIVE University of North Dakota, Grand Forks, ND, United States HOUSES AS CONTROL STRATEGIES TO REDUCE AEDES 257 AEGYPTI POPULATION DENSITY IN DENGUE ENDEMIC NEIGHBORHOODS INTERACTIONS BETWEEN BACTERIA ASSOCIATED Rafael Maciel-de-Freitas, Mariana R. David, Anielly A. Ferreira WITH MOSQUITO DIGESTIVE TRACTS AND LA CROSSE Oswaldo Cruz Foundation, Rio de Janeiro, Brazil VIRUS 252 Justin R. Anderson, Jonathan D. Joyce, Amber A. Bales Radford University, Radford, VA, United States EFFECTS OF ENVIRONMENTAL VARIABLES AND 258 PREDATORY ON SWARMING AND MATING BEHAVIOUR

OF NATURAL POPULATIONS OF ANOPHELES GAMBIAE Thursday, November 19 DYNAMICS OF MALARIA PREVALENCE AND VECTOR S.S. IN BURKINA FASO ABUNDANCE IN SENTINEL SITES IN WESTERN KENYA: 1 2 3 Simon P. Sawadogo , Antoine Sanon , Idrissa Dicko , Moussa ROLE OF INSECTICIDE-TREATED BEDNETS AND Namountougou1, Hyacinthe K. Toe1, Ali Ouari4, Abdoulaye Diabate1, Carlo Costantini5, Jean-Bosco Ouedraogo1, Robert T. Guiguemde4, Roch K. Dabire1 ARTEMISININ-BASED COMBINATION THERAPY 1Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso, 2University Guofa Zhou1, Yaw Afrane2, Andrew K. Githeko3, Guiyun Yan1 of Ouagadougou, Ouagadougou, Burkina Faso, 3Université polytechnique de Bobo 1University of California at Irvine, Irvine, CA, United States, 2International Center of Dioulasso, Bobo-Dioulasso, Burkina Faso, 4Centre muraz, Bobo-Dioulasso, Burkina Insect Physiology and Ecology, Nairobi, Kenya, 3Kenya Medical Research Institute, Faso, 5IRD/OCEAC, Yaoundé, Cameroon Kisumu, Kenya

253 PNEUMONIA, RESPIRATORY INFECTIONS SEASONAL ABUNDANCE AND NATURAL INFECTION AND TUBERCULOSIS OF THE SAND FLY LUTZOMYIA LONGIFLOCOSA IN A DOMESTIC FOCUS OF AMERICAN CUTANEOUS 259 LEISHMANIASIS IN CHAPARRAL, TOLIMA, COLOMBIA Dairo Marin1, Cristina Ferro1, Leonard Munstermann2, Clara Ocampo1 NOSOCOMIAL TRANSMISSION OF PULMONARY 1Centro Internacional de Entrenamiento e Investigaciones Medicas, CIDEIM, Cali, TUBERCULOSIS IN A SECONDARY HEALTH-CARE Colombia, 2Yale University School of Public Health, New Haven, CT, United States FACILITY IN NIGERIA Aderemi O. Kehinde1, Abubakar Baba2, Rasheed A. Bakare1, Olusoji M. Ige1, 254 Confort Gbadeyanka3 1College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria, URBAN STREAM POLLUTION INCREASES MOSQUITO 2University College Hospital, Ibadan, Nigeria, 3Jericho Chest Hospital, Ibadan, Nigeria FITNESS AND DISEASE VECTOR POTENTIAL Carolyn L. Keogh, Uriel D. Kitron, Andy M. Nguyen, Gonzalo Vazquez- 260 Prokopec, Luis F. Chaves Emory University, Atlanta, GA, United States TUBERCULOSIS DIAGNOSTIC DELAY IN HIGH- INCIDENCE SHANTYTOWN COMMUNITIES Samuel G. Schumacher1, Rosario Montoya2, Robert H. Gilman3, Jessica Franco2, Betty Valiente2, Silvia Carrera2, Karine Zevallos2, Dami Onifade2, Colleen Acosta4, Carlton A. Evans5 1Universidad Peruana Cayetano Heredia, Lima, Peru, 2Asociación Benefi ca Prisma, Lima, Peru, 3Johns Hopkins Bloomberg School of Hygiene and Public Health, Baltimore, MD, United States, 4IFHAD: Innovation For Health And Development, London, United Kingdom, 5London School of Hygiene and Tropical Medicine, London, United Kingdom

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TUBERCULOSIS AND NUTRITIONAL STATUS IN MOLECULAR CHARACTERIZATION OF ADENOVIRUS TRANSITIONAL COMMUNITIES. CIRCULATING IN CENTRAL AND SOUTH AMERICA Chulanee Jongkaewwattana1, Samuel G. Schumacher1, Karine Zevallos2, DURING THE 2006-2008 PERIOD Mathew Baldwin2, Alejandro Necochea2, Rosario Montoya2, Robert H. Josefi na Garcia1, Merly Sovero1, V. Alberto Laguna-Torres1, Jorge Gomez2, Gilman3, Carlton A. Evans4 Wilson Chicaiza3, Melvin Barrantes4, Felix Sanchez5, Mirna Jimenez6, 1Universidad Peruana Cayetano Heredia, Lima, Peru, 2Asociación Benefi ca Prisma, Guillermo Comach7, Ivette De Rivera8, Roberto Agudo9, Ana E. Arango10, Lima, Peru, 3Johns Hopkins Bloomberg School of Hygiene and Public Health, Baltimore, Alma Barboza11, Nicolas Aguayo11, Tadeusz Kochel1 MD, United States, 4Wellcome Centre for Clinical Tropical Medicine Imperial College, 1Naval Medical Research Center Detachment, Lima, Peru, 2Direccion General de London, United Kingdom Epidemiologia, Lima, Peru, 3Hospital Vozandes, Quito, Ecuador, 4Hospital San Francisco Solano, Buenos Aires, Argentina, 5Hospital Infantil Manuel de Jesus Rivera, Managua, 262 Nicaragua, 6Hospital Nacional Metapan, Santa Ana, El Salvador, 7Laboratorio Regional de Diagnostico e Investigacion del Dengue y otras Enfermedades Virales, Maracay, PREVALENCE OF FLUOROQUINOLONE RESISTANCE Venezuela, 8Universidad Nacional Autonoma de Honduras, Tegucigalpa, Honduras, 9Servicio Departamental de Salud, Cochabamba, Bolivia, 10Grupo de Inmunovirologia, AMONG TUBERCULOSIS PATIENTS IN SHANGHAI, Universidad de Antioquia, Medellin, Colombia, 11Asociacion Rayos de Sol, Asuncion, CHINA Paraguay Xia Li1, Peng Xu2, Qian Gao1 1Fudan University, Shanghai, China, 2Shanghai Centers for Disease Control and 268 Prevention, Shanghai, China RESISTANCE TO NEURAMINIDASE INHIBITORS IN 263 INFLUENZA A/H1N1 IN LATIN AMERICA: EUROPEAN STRAINS ARRIVE TO THE NEW CONTINENT AN EFFECTIVE INFLUENZA VACCINE CANDIDATE 1 1 1 2 BASED ON BACULOVIRUS PSEUDOTYPING Josefi na Garcia , Merly Sovero , V. Alberto Laguna-Torres , Jorge Gomez , Wilson Chicaiza3, Melvin Barrantes4, Felix Sanchez5, Mirna Jimenez6, Xianchun Tang, Ted Ross Guillermo Comach7, Ivette De Rivera8, Roberto Agudo9, Ana E. Arango10, University of Pittsburgh, Pittsburgh, PA, United States Alma Barboza11, Nicolas Aguayo11, Tadeusz Kochel1 1Naval Medical Research Center Detachment, Lima, Peru, 2Direccion General de 264 Epidemiologia, Lima, Peru, 3Hospital Vozandes, Quito, Ecuador, 4Hospital Materno Infantil San Francisco Solano, Buenos Aires, Argentina, 5Hospital Infantil Manuel 6 ANALYSIS OF STRAIN TRANSMISSION DURING AN de Jesus Rivera, Managua, Nicaragua, Hospital Nacional de Metapan, Santa Ana, El Salvador, 7Laboratorio Regional de Diagnóstico e Investigación del Dengue y otras EPIDEMIC OF MULTI-DRUG RESISTANT TUBERCULOSIS Enfermedades Virales, Maracay, Venezuela, 8Universidad Nacional Autonoma de AMONG AIDS PATIENTS RECEIVING DIRECTLY Honduras, Tegucigalpa, Honduras, 9Servicio Departamental de Salud, Cochabamba, OBSERVED THERAPY SHORT-COURSE (DOTS) Bolivia, 10Grupo de Inmunovirología, Universidad de Antioquia, Medellin, Colombia, 11 Maria-Graciela Hollm-Delgado1, Fanny Arenas2, Juliana Cordova2, Patricia Asociacion Rayos de Sol, Asuncion, Paraguay Sheen2, Carlton A. Evans3, Eduardo Ticona4, Robert H. Gilman on behalf of TB Collaborative Group5 SYSTEMIC INFECTIONS 1Université de Montréal, Montréal, QC, Canada, 2Universidad Peruana Cayetano Heredia, Lima, Peru, 3Imperial College London, London, United Kingdom, 4Hospital Dos de Mayo, Lima, Peru, 5Johns Hopkins Bloomberg School of Public Health, Baltimore, 269 MD, United States EVALUATION OF THE USE OF EGYPTIAN LEPTOSPIRA 265 ISOLATES IN THE MICROSCOPIC AGGLUTINATION TESTING (MAT) DIAGNOSIS OF LEPTOSPIROSIS EXAMINING THE ENVIRONMENTAL EFFECTS ON 1 2 3 4 INFLUENZA TRANSMISSION IN WARM CLIMATE USING Clinton K. Murray , Michael R. Gray , Katrin Mende , Guillermo Pimentel , Tina Parker4, Ahmed Samir4, Bassem Abdel Rahman4, Duane R. Hospenthal1 NEURAL NETWORK 1Brooke Army Medical Center, Fort Sam Houston, TX, United States, 2United States Radina P. Soebiyanto, Farida Adimi, Richard Kiang Army Veterinary Command, Fort Sam Houston, TX, United States, 3Infectious Disease NASA Goddard Space Flight Center, Greenbelt, MD, United States Clinical Research Program, Bethesda, MD, United States, 4NAMRU3, Cairo, Egypt

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A RARE CASE OF NECROTIZING GRANULOMATOUS IGM ANTIBODIES AGAINST Q FEVER IN ACUTE FEBRILE PLEURITIS PRESENTING WITH EMPYEMA PATIENTS IN ACCRA, GHANA Javeria Shakil, Deborah Asnis Naiki Puplampu1, Shirley Odoom1, Janice Tagoe1, Engy Emil Habashy2, Flushing Hospital Medical Center, Flushing, NY, United States Michael Wilson1, Gregory Raczniak3, Karl Kronmann3, Edward Nyarko4, Prince Agbenohevi4, Moustapha Abdel Fadeel2, Guillermo Pimentel2, Kwadwo Koram1 1Noguchi Memorial Institute for Medical Research, Legon, Ghana, 2Naval Medical Research Unit-3, Cairo, Egypt, 3Noguchi Memorial Institute for Medical Research/Naval Medical Research Unit-3, Ghana Detachment, Legon, Ghana, 437th Military Hospital, Accra, Ghana

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COMPARISON OF VECTOR SNAILS OF 271 SCHISTOSOMIASIS IN TWO SITES ALONG THE WEIJAH LAKE IN GHANA EIGHT YEAR-STUDY OF HUMAN FASCIOLIASIS IN 1 2 3 THE ANDEAN PERUVIAN REGION: A PUBLIC HEALTH Naa Adjeley Tawiah , Godfred Futabi , Kwadwo K. Frempong , Joseph Otchere3, Dominic Edoh2 PROBLEM 1University of Ghana Medical School, Microbiology Department, Accra, Ghana, 2Zoology Luis A. Marcos1, Angelica Terashima2, Eduardo Gotuzzo2 Department, University of Ghana, Accra, Ghana, 3Noguchi Memorial Institute for 1University of Texas, Houston, TX, United States, 2Instituto de Medicina Tropical Medical Research, Accra, Ghana Alexander von Humboldt, Lima, Peru 278 272 MULTICOMPONENT REACTION CHEMISTRY FOR NEW DEVELOPMENT OF A QUANTITATIVE REAL TIME PCR SCHISTOSOMIASIS DRUGS TO ANALYZE THE EXPRESSION PROFILE OF TH1/ Kareem Khoury TH2 CYTOKINES GENES IN A RABBIT MODEL OF University of Pittsburgh, Pittsburgh, PA, United States FASCIOLIASIS (ACMCIP Abstract) Ana M. Espino, Francheska Rivera University of Puerto Rico, School of Medicine, San Juan, Puerto Rico (ACMCIP Abstract) 279

273 IMMUNOLOGICAL MEMORY IN OFFSPRING BORN TO BABOONS (PAPIO ANUBIS) INFECTED WITH IN VIVO IMAGING ON BILE-CHEMOTACTIC MIGRATION SCHISTOSOMIASIS MANSONI OF JUVENILE CLONORCHIS SINENSIS IN RABBITS David Langoi1, Thomas Kariuki1, Michael Gicheru2, Idle O. Farah1, Hans- 3 Sung-Jong Hong, Tae Im Kim, Won Gi Yoo, Hye Lim Kang, Ji Sung Jung, Erik Carlsson 1 2 Byung Kook Kwak, Ju–Won Seok Institute of Primate Research, Nairobi, Kenya, Kenyatta University, Nairobi, Kenya, 3 Chung-Ang University, Seoul, Republic of Korea Uppsala University, Uppsala, Sweden 280

TREMATODES - SCHISTOSOMIASIS Thursday, November 19 SCHISTOSOMA MANSONI: HOW TO MAKE A FEMALE 274 Christoph Grunau, Jérôme Boissier, Céline Cosseau, Sophie Beltran, David Duval, Julien Portela, Benjamin Gourbal, André Theron, Guillaume Mitta PROTEIN KINASES OF THE PARASITE SCHISTOSOMA University of Perpignan, Perpignan, France MANSONI 281 Luiza F. Andrade1, Lívia Avelar1, Jerônimo Ruiz1, Adhemar Zerlotini2, Laila Nahum1, Guilherme Oliveira1 1Fiocruz - CpQRR, Belo Horizonte, Brazil, 2UFMG, Belo Horizonte, Brazil CLONING, CHARACTERIZATION, AND EXPRESSION OF (ACMCIP Abstract) SCHISTOSOMA MANSONI MICRORNAS Ms. Mariana C. Simoes 275 Oswaldo Cruz Foundation (Fiocruz) - Centro de pesquisas Rene Rachou (CPqRR), Belo Horizonte, Brazil SCHISTOSOMA MANSONI VACCINE CANDIDATE SCREENING BY BI-DIMENSIONAL WESTERN BLOT 282 Fernanda Ludolf, Rosiane da Silva-Pereira, Paola Patrocínio, Rodrigo Corrêa-Oliveira, Guilherme Oliveira Centro de Pesquisa Rene Rachou, Belo Horizonte, Brazil STOCHASTIC MODELING OF SCHISTOSOMIASIS (ACMCIP Abstract) JAPONICUM TRANSMISSION Yao Ning, Kin On Kwok, Steven Riley 276 School of Public Health, The University of Hong Kong, Hong Kong, China

RURAL TOURISM AND SCHISTOSOMIASIS: THE 283 GEOGRAPHIC INFORMATION SYSTEM AS A TOOL FOR IDENTIFICATION OF PRIORITY AREAS FOR THE SCHISTOSOMA MANSONI RACK1 IS EXPRESSED INTERVENTION IN THE GONADS AND IS LIKELY INVOLVED IN Ronaldo G. C. Scholte, Omar S. Carvalho, Guilherme C. Oliveira, Martin J. EMBRYOGENESIS Enk Livia Avelar1, Colette Dissous2, Christoph Grevelding3, Guilherme Oliveira1 Centro de Pesquisas René Rachou/Fiocruz, Belo Horizonte, Brazil 1Rene Rachou Institute of Research, Oswaldo Cruz Foundation, Belo Horizonte, Brazil, 2Institut Pasteur, Lille, France, 3Heinrich-Heine-Universität, Düsseldorf, Germany

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284 290

SCHISTOSOMA MANSONI PKA: A POTENTIAL NEW DRUG RELATIVE ROLES OF TLRS AND RNA-HELICASES IN TARGET IMMUNE RECOGNITION OF RIFT VALLEY FEVER VIRUS Brett E. Swierczewski, Stephen J. Davies Megan Ermler, Heidi Page, Lewis Yuan, A. Desiree LaBeaud, Charles King, Uniformed Services University of the Health Sciences, Bethesda, MD, United States James Kazura, Amy Hise (ACMCIP Abstract) Case Western Reserve University, Cleveland, OH, United States

VIRUSES - OTHER 291 DECTECTION AND QUANTIFICATION OF HUMAN 285 HERPESVIRUS 8 IN SAMPLES OF PATIENTS WITH AIDS- ASSOCIATED KAPOSI’S SARCOMA BY REAL TIME PCR DETECTION AND DISCOVERY OF VIRAL PATHOGENS Paula Renata Machado, Kleber Farias, Benedito Fonseca ASSOCIATED WITH ACUTE PEDIATRIC RESPIRATORY University of São Paulo, Ribeirão Preto, Brazil ILLNESS IN NICARAGUA Nathan Yozwiak1, Aubree Gordon1, Saira Saborio2, Peter Skewes-Cox3, 292 Guillermina Kuan4, Angel Balmaseda2, Eva Harris1, Joseph L. DeRisi3 1University of California, Berkeley, CA, United States, 2Departamento de Virología, SURVEILLANCE OF AVIAN INFLUENZA IN THE LIVE Centro Nacional de Diagnóstico y Referencia, Ministerio de Salud, Managua, Nicaragua, BIRD MARKETS OF PERU 3University of California, San Francisco, CA, United States, 4Centro de Salud Sócrates 1 1 2 1 Flores Vivas, Ministerio de Saludornia, Managua, Nicaragua Ana Patricia Mendoza , Bruno Ghersi , Marcela Uhart , Tadeusz Kochel , Joel Montgomery1, Donald Brightsmith1 1 2 286 Naval Medical Research Center Detachment, Washington, DC, United States, Wildlife Conservation Society, New York, NY, United States

MOLECULAR EVIDENCE OF HANTAVIRUS DOBRAVA 293 SPILLOVER INFECTION IN BANK VOLE Miša Korva1, Darja Duh1, Nataša Knap1, Tomi Trilar2, Tatjana Avšič-Županc1 HUMAN INNATE IMMUNE RESPONSE TO RIFT VALLEY 1 2 Medical Faculty, Ljubljana, Slovenia, Slovenian Museum of Natural History, FEVER VIRUS INFECTION Ljubljana, Slovenia Angelle Desiree LaBeaud, Heidi E. Page, Megan E. Ermler, Amy G. Hise 287 Case Western Reserve University, Cleveland, OH, United States 294 PRECIPITATING AND NEUTRALIZING ANTIBODY RESPONSE TO HIGHLY PATHOGENIC AVIAN GEOGRAPHIC AND CLIMATOLOGIC RISK FACTORS INFLUENZA, NIGERIA ASSOCIATED WITH THE 2006-2007 KENYA RIFT Clement A. Meseko, Anthony Egbuji, Folorusho D. Fasina, Agnes T. VALLEY FEVER OUTBREAK: A POPULATION-BASED Oladokun, Stella Idachaba FAO Regional Lab for Avian Infl uenza, National Veterinary Research Institute, Jos MULTIVARIABLE MODEL Plateau State, Nigeria Allen Hightower1, Carl Kinkade2, Patrick Nguku3, Tom Ksiazek4, S. K. Sharif3, Samuel Amwayi3, David Schabel5, Daniel Feikin1, Maurice Ombok1, 288 Kariuki Njenga1, Robert Breiman1 1Centers for Disease Control and Prevention - Kenya, Nairobi, Kenya, 2Centers for Disease Control and Prevention, Atlanta, GA, United States, 3Ministry of Public Health, PROMOTING BAMBOO SKIRTS FOR DATE PALM Nairobi, Kenya, 4University of Texas, Medical Branch, Galveston, TX, United States, SAP COLLECTION IN BANGLADESH: A COMMUNITY 5US Army Medical Research Unit – Kenya, Nairobi, Kenya INTERVENTION TO PREVENT NIPAH VIRUS TRANSMISSION Poster Session A ACMCIP Abstracts – Nazmun Nahar, Utpal Kumar Mondal, Emily S. Gurley, M. Jahangir Molecular, Cellular and Immunoparasitology Hossain, A. K. Khan, Elizabeth Oliveras, Rouha Anamika Sarkar, S.M. Azad, Rebeca Sultana, M.S. Khan, Stephen P. Luby 46, 47, 58, 74, 117, 123, 124, 127, 128, 129, 132, 134, 136, 138, International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh 140, 141, 142, 144, 146, 147, 157, 159, 170, 182, 191, 197, 198, 200, 201, 202, 203, 204, 205, 206, 207, 209, 210, 211, 214, 216, 289 218, 230, 241, 272, 274, 275, 278, 284

HUMAN MONKEYPOX GENOMIC DIVERGENCE AND Burroughs Wellcome Fund/ASTMH Fellowship Committee DETERMINANTS OF PATHOGENICITY Meeting Stephen K. Gire1, Anjan Purkayastha1, Jay Goff2, Vicki Olsen2, Inger Damon3, John Huggins2, Jean-Jacque Muyembe4, Lisa Hensley2, Kate Jackson Rubins1 1Whitehead Institute for Biomedical Research, Cambridge, MA, United States, 2United Thursday, November 19, Noon - 2 p.m. States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United Clinical Standards and Treatment Guidelines Committee States, 3Centers for Disease Control and Prevention, Atlanta, GA, United States, 4Institut National du Reserche Biomedicale, Kinshasa, The Democratic Republic of the Congo Room 8211 Thursday, November 19, 12:15 p.m. - 1:15 p.m.

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Certifi cate Exam Executive Committee Meeting Mid-Day Session 28 Room 8217 Wellcome Trust Seminar: Successful Research: Grant Thursday, November 19, 12:15 p.m. - 1:15 p.m. Writing, Mentorship and Career Advice Late Breaker Abstract Session 25 Washington 5 Thursday, November 19, 12:15 p.m. - 1:15 p.m. Late Breakers in Clinical Tropical Medicine Health research funding opportunities are as competitive as ever and key Delaware A skills are needed to create successful longstanding research programs. The Thursday, November 19, 12:15 p.m. - 1:15 p.m. Wellcome Trust has convened this session to explore two important topics relating to successful research programs: mentoring and grant writing. The This session is specifi cally designed for brief presentations of new data session will open with a presentation on both of these topics and how their obtained after the closing date for abstract submission. Presentations feature successful application can lead to longstanding large and sustainable research reports of clinical trials, preliminary data on new outbreaks of disease or programs, such as the KEMRI-Wellcome Trust Research Programme based individual case reports of interest. See the Late Breaker handout in your in Kilifi , Kenya. A discussion will follow regarding what constitutes good registration packet for the presentation schedule. grant writing from the Wellcome Trust perspective. The next presentation will cover innovative research mentoring models being used by the Southern CHAIR Africa Consortium for Research Excellence, one of the new Wellcome Trust- Barbara L. Herwaldt funded African Institutions awards. A contrasting perspective on mentorship Centers for Disease Control and Prevention, Atlanta, GA, United States will be provided from a longstanding program on African Malaria research in institutions across Africa. Finally, personal perspectives will be shared on Jason D. Maguire successfully progressing in a career in tropical medicine. Naval Medical Center Portsmouth, Portsmouth, VA, United States Late Breaker Abstract Session 26 CHAIR Michael Chew Wellcome Trust, London, United Kingdom Late Breakers in Basic Science/Molecular Biology Philip T. LoVerde Virginia AB Southwest Foundation for Biomedical Research, San Antonio, United States Thursday, November 19, 12:15 p.m. - 1:15 p.m. 12:15 p.m.

This session is specifi cally designed for brief presentations of new data CAREER ADVICE ON SUCCESSFULLY BUILDING A Thursday, November 19 obtained after the closing date for abstract submission. See the Late Breaker SUSTAINABLE RESEARCH PROGRAM handout in your registration packet for the presentation schedule. Kevin Marsh KEMRI-Wellcome Trust Research Programme, Kilifi , Kenya CHAIR Gregory D. Ebel 12:30 p.m. University of New Mexico School of Medicine, Albuquerque, NM, United States WHAT MAKES A GOOD GRANT APPLICATION? THE Stefan Kappe WELLCOME TRUST PERSPECTIVE Seattle Biomedical Research Institute, Seattle, WA, United States Ruth Branston Meet the Professors 27 Wellcome Trust, London, United Kingdom 12:45 p.m. Meet the Professors A: Enigmatic and Teaching Cases MENTORSHIP MODELS FROM THE SOUTHERN AFRICA Virginia C CONSORTIUM FOR RESEARCH EXCELLENCE (SACORE) Thursday, November 19, 12:15 p.m. - 1:15 p.m. Newton Kumwenda University of Malawi, Blantyre, Malawi A panel of professors will present one clinical case each of a tropical disease specifi c to a particular region that they have found a challenge to manage or 1 p.m. diagnose. If there is time, participants may be able to present enigmatic cases MENTORING MODELS AND A PERSONAL PERSPECTIVE for the audience and panel to consider. FOR AFRICAN MALARIA RESEARCH - LESSONS CHAIR LEARNED FROM THE GATES MALARIA PARTNERSHIP AND THE MALARIA CAPACITY DEVELOPMENT Davidson H. Hamer Boston University School of Public Health, Boston, MA, United States CONSORTIUM Brian Greenwood PANELISTS London School of Hygiene and Tropical Medicine, London, United Kingdom David Boulware Wilfred Mbacham University of Minnesota, Minneapolis, MN, United States University of Yaounde, Yaounde, Cameroon Hector H. Garcia Universidad Peruana Cayetano Heredia, Lima, Peru

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Poster Session A Viewing CHAIR Michelle Chang Exhibit Hall B South Centers for Disease Control and Prevention, Atlanta, GA, United States Thursday, November 19, 1:30 p.m. - 7 p.m. Bernard Nahlen President’s Malaria Initiative/United States Agency for International Development, Symposium 29 Washington, DC, United States 1:30 p.m. The Malaria Eradication Paradigm: Implications for THE PRESIDENT’S MALARIA INITIATIVE: A Transmission Blocking Vaccines COLLABORATIVE APPROACH FOR SCALING UP Salon 1 MALARIA CONTROL INTERVENTIONS Thursday, November 19, 1:30 p.m. - 3:15 p.m. Trenton Ruebush United States Agency for International Development, Washington, DC, United States Malaria vaccines are an essential part of the tool kit needed if the long-term goal of eradication is to be achieved. This symposium will address the impact 1:50 p.m. of the eradication agenda on vaccine research and development, with a focus PMI CONTRIBUTIONS TO REACHING ROLL BACK on different aspects of transmission blocking vaccines. MALARIA TARGETS IN AFRICA CHAIR Michelle Chang Centers for Disease Control and Prevention, Atlanta, GA, United States Christian Loucq PATH Malaria Vaccine Initiative, Bethesda, United States 2:10 p.m. Ashley Birkett PATH Malaria Vaccine Initiative, Bethesda, MD, United States SCALING UP INDOOR RESIDUAL SPRAYING IN ANGOLA Filomeno Fortes 1:30 p.m. National Malaria Control Program, Luanda, Angola BIOLOGY OF MALARIA VECTORS 2:30 p.m. Frank Collins University of Notre Dame, Notre Dame, IN, United States SCALE-UP OF CASE MANAGEMENT WITH ARTEMISININ- BASED COMBINATION THERAPY (ACTS) AT THE 1:55 p.m. HEALTH FACILITY LEVEL IN MALAWI VACCINE APPROACHES BASED ON VECTOR ANTIGENS Doreen Ali National Malaria Control Program, Lilongwe, Malawi Rhoel Dinglasan Johns Hopkins Malaria Research Institute, Baltimore, MD, United States 2:50 p.m. 2:25 p.m. INNOVATIONS IN REACHING UNIVERSAL COVERAGE PARASITE BIOLOGY AS IT RELATES TO TRANSMISSION WITH MALARIA DIAGNOSTICS AND ARTEMISININ BLOCKING VACCINE DEVELOPMENT CONTAINING COMBINATION THERAPY (ACTS) IN Robert Sinden SENEGAL Imperial College London, London, United Kingdom Moussa Thior Programme National de Lutte contre le Paludisme (PNLP), Dakar, Senegal 2:50 p.m. VACCINE APPROACHES BASED ON PARASITE ANTIGENS Symposium 31 Nirbhay Kumar Johns Hopkins University, Baltimore, MD, United States Changing the Climate: A Data-Driven Discussion about Climate Symposium 30 Salon 3 The President’s Malaria Initiative (PMI): A Collaborative Thursday, November 19, 1:30 p.m. - 3:15 p.m. Model to Support National Malaria Control Programs in There is concrete evidence that the global climate is changing, and these Africa changes are expected to have a major impact on human health as surface temperatures rise, agricultural belts shift, and extreme weather events become Salon 2 more commonplace, to name a few expected effects. Although most scientists Thursday, November 19, 1:30 p.m. – 3:15 p.m. agree that climate change is underway, the role it plays in infectious disease transmission is still in contention. As with all debates, data are needed to This symposium will provide an introduction to the President’s Malaria promote an informed understanding. To that end, this symposium will address Initiative and the model by which it works with host governments and the use, utility, and limitations of weather and climate models toward a goal National Malaria Control Programs. The symposium will also provide data of providing data-driven evidence of the links between weather, climate, on the number of benefi ciaries reached with PMI support to date, and early specifi c pathogens and ultimately, human health. To this end, a leading evidence of impact from selected countries. Case studies of successful scale- climate scientist will discuss available weather and climate models followed by up will be presented by National Malaria Control Program managers from evidence-based presentations on the established effects of climate variability/ Angola, Malawi and Senegal. change on specifi c climate sensitive diseases: meningitis, malaria, plague and other vector-borne bacterial pathogens.

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CHAIR 2:20 p.m. Mary H. Hayden TRACHOMA MESOENDEMIC COMMUNITIES: National Center for Atmospheric Research, Boulder, CO, United States MASS TREATMENT WITH A SINGLE ROUND OF Emily Zielinski-Gutierrez AZITHROMYCIN AND HIGH COVERAGE IS NOT Centers for Disease Control and Prevention, Fort Collins, CO, United States SUFFICIENT TO ELIMINATE INFECTION WITH C. 1:30 p.m. TRACHOMATIS Sheila K. West BEYOND CLIMATE SCIENCE: THE POTENTIAL FOR Johns Hopkins University, Baltimore, MD, United States HEALTH FORECASTING Eric Barron 2:45 p.m. National Center for Atmospheric Research, Boulder, CO, United States TREATMENT ISSUES IN THE MOST HYPER-ENDEMIC 1:55 p.m. AREAS Thomas Lietman CLIMATE AND VECTOR-BORNE BACTERIAL ZOONOSES: University of California San Francisco, San Francisco, CA, United States PERSPECTIVES FROM NORTH AMERICA AND EAST AFRICA Symposium 33 Rebecca Eisen Centers for Disease Control and Prevention, Fort Collins, CO, United States Health Care Worker/Researchers in Overseas Care Settings 2:20 p.m. with Potential Disease Transmission: What’s the Risk and CLIMATE INFORMATION FOR THE CONTROL OF What Should You Do? MENINGITIS: THE EVIDENCE TO DATE Delaware B Madeleine Thomson Thursday, November 19, 1:30 p.m. - 3:15 p.m. The International Research Institute for Climate and Society, Palisades, NY, United States Large numbers of U.S. scientists and health care providers are working in care settings in lesser developed countries and have some unique and nosocomial 2:45 p.m. risks higher than the usual traveler. We will discuss some of these risks, CLIMATE INFORMED EARLY WARNING FOR MALARIA potential management, controversies and risk reduction strategies. Stephen J. Connor CHAIR International Research Institute for Climate and Society, Palisades, NY, United States Thursday, November 19 Naomi E. Aronson Symposium 32 Uniformed Services University of the Health Sciences, Bethesda, MD, United States Rodney Coldren SAFE Strategy for Trachoma Control: Updates from Uniformed Services University of the Health Sciences, Bethesda, MD, United States Partnership for Rapid Elimination of Trachoma (PRET) 1:30 p.m. Delaware A MANAGEMENT OF NEEDLESTICK INJURIES Thursday, November 19, 1:30 p.m. - 3:15 p.m. Sybil Tasker PPD, Inc., Cairo, Egypt Surgery, antibiotics, facial hygiene and environmental change form the WHO- endorsed SAFE strategy for trachoma control. This symposium will present 1:55 p.m. data in support of new approaches to delivery of surgery and antibiotics for SEVERE RESPIRATORY PATHOGENS trachoma-endemic countries at varying stages of endemicity. Timothy H. Burgess CHAIR Naval Medical Research Center, Silver Spring, MD, United States Sheila K. West 2:20 p.m. Johns Hopkins University, Baltimore, MD, United States VIRAL HEMORRHAGIC FEVERS IN THE HEALTH CARE 1:30 p.m. SETTING MAKING SURGERY MORE STRAIGHTFORWARD MAY Mark Kortepeter IMPROVE TRICHIASIS SURGERY OUTCOMES: A NEW United States Army Medical Research Institute for Infectious Diseases, Ft Detrick, MD, United States TOOL Emily W. Gower 2:45 p.m. Johns Hopkins University, Baltimore, MD, United States MDR/XDR TUBERCULOSIS EXPOSURE 1:55 p.m. Naomi E. Aronson Uniformed Services University of the Health Sciences, Bethesda, MD, United States TRACHOMA IN A LOW PREVALENCE SETTING: IS ONE ROUND OF TREATMENT ENOUGH IN THE GAMBIA? Robin Bailey London School of Hygiene and Tropical Medicine, London, United Kingdom

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Scientifi c Session 34 2:15 p.m. 298 Malaria - Drug Development Virginia AB MIRINCAMYCIN: REASSESSMENT OF A PROMISING Thursday, November 19, 1:30 p.m. - 3:15 p.m. ANTI-MALARIAL AGENT WITH POTENTIAL IN A PLASMODIUM CYNOMOLGI RELAPSING MALARIA CHAIR MONKEY MODEL Stephan Duparc Susan D. Fracisco1, Montip Gettayacamin2, Victor Melendez1, Qigui Li1, Medicines for Malaria Venture, Geneva, Switzerland Pisit Khemawoot2, Bryan L. Smith1, David Saunders2, Kent Bennett1, William Tina S. Skinner-Adams McCalmont1, Charlotte Lanteri1, Geoffrey Dow1, Yarrow Rothstein1, Carl Queensland Institute of Medical Research, Brisbane, Australia Craft3, Paktiya Teja-isavadharm2, Imerbsin Rawiwan2, Alan Magill1, A.J. Lin1, Ian Bathurst3, Richard Westerman4, Colin Ohrt1 1:30 p.m. 1WRAIR Experimental Therapeutics, Silver Spring, MD, United States, 2Armed Forces Research Institute of the Medical Sciences, Bangkok, Thailand, 3Medicines for Malaria 295 Venture, Geneva, Switzerland, 4MALDEVCO, Kalamazoo, MI, United States 2:30 p.m. A NOVEL ANTIMALARIAL CHEMOTYPE WITH EFFICACY AGAINST BOTH EXOERYTHROCYTIC AND 299 ERYTHROCYTIC STAGES Jane X. Kelly1, Michael O’Neil2, Victor Melendez2, Erin Harris2, Arba Ager3, UNDERSTANDING THE ANTIMALARIAL ACTION OF THE Martin Smilkstein4, Isaac Forquer1, Rosie Dodean1, Rolf Winter1, Dave HIV PROTEASE INHIBITORS Hinrichs1, Mike Riscoe1 1 2 1 1Portland VA Medical Center, Portland, OR, United States, 2Walter Reed Army Tina S. Skinner-Adams , Katherine T. Andrews , Donald L. Gardiner , 1 Institute of Research, Division of Experimental Therapeutics, Silver Spring, MD, United James S. McCarthy 1 2 States, 3University of Miami, School of Medicine, Miami, FL, United States, 4Oregon Queensland Institute of Medical Research, Brisbane, Australia, Eskitis Institute for Translational Research and Drug Development Institute, Portland, OR, United States Cell and Molecular Therapies, Griffi th University, Brisbane, Australia 1:45 p.m. 2:45 p.m.

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NEW INSIGHTS INTO MECHANISM OF HEMOLYTIC EFFICACY OF PYRONARIDINE/ARTESUNATE IN TOXICITY AND ANTIMALARIAL EFFICACY CLINICAL TRIALS IN PATIENTS WITH UNCOMPLICATED OF 8-AMINOQUINOLINES: EVALUATION OF ACUTE PLASMODIUM FALCIPARUM OR PLASMODIUM VIVAX STEREOSELECTIVE PROFILES MALARIA: RESULTS OF AN INTEGRATED ANALYSIS 1 1 2 Babu L. Tekwani1, Rajnish Sahu2, N. P. Dhammika Nanayakkara2, Larry A. Stephan Duparc , Isabelle Borghini-Fuhrer , J. Carl Craft , Sarah Arbe- 3 3 4 5 1 Barnes , Robert M. Miller , Chang-Sik Shin , Lawrence Flenckenstein Walker 1 2 1National Center for Natural Products Research and Department of Pharmacology, Medicines for Malaria Venture, Geneva, Switzerland, Former Medicines for Malaria 3 School of Pharmacy, University of Mississippi, University, MS, United States, 2National Venture, Geneva, Switzerland, Fulcrum Pharma Developments Ltd, Hemel Hempstead, 4 5 Center for Natural Products Research, School of Pharmacy, University of Mississippi, United Kingdom, Shin Poong Pharmaceuticals, Seoul, Republic of Korea, University of University, MS, United States Iowa, Iowa City, IA, United States 2 p.m. 3 p.m.

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AN IN VIVO GLUCOSE-6-PHOSPHATE DEHYDROGENASE SAFETY, EFFICACY AND PHARMACOKINETIC (G6PD)-DEFICIENT MOUSE MODEL TO PREDICT THE COMPARISON OF FIXED-DOSE ARTESUNATE- HEMOLYTIC TOXICITY OF PRIMAQUINE AMODIAQUINE “ASAQ” WITH NON-FIXED COMBINATION OF AS AND AQ AMONG KENYAN Prabhati Ray1, Peng Zhang1, Xiugong Gao1, Hiroshi Ishida1, Aileen Chua1, Jack Amnuaysirikul1, Peter J. Weina1, Max Grogl1, Colin Ohrt1, Aruna ADULTS Sampath2, Alan J. Magill1 Bernhards Ogutu1, Elizabeth Juma1, Vincent Jullien2, Gwenaelle Carn3, 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2University Jean-René Kiechel3 of Mississippi, University, MS, United States 1Kenya Medical Research Institute (KEMRI), Nairobi, Kenya, 2Cardinal Health Systems, Paris, France, 3Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

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Symposium 35 1:30 p.m. 302 Determining Etiology and Burden of Pneumonia Around the Globe RELATIONSHIP BETWEEN BITE-TO-HOSPITAL TIME Virginia C AND MORBIDITY IN VICTIMS OF CARPET VIPER BITE IN Thursday, November 19, 1:30 p.m. - 3:15 p.m. NIGERIA Oluwagbenga P. Ogunfowokan1, Jacob A. Dawam2, Livinus L. Odor2 This symposium will summarize new efforts to determine pneumonia burden 1National Hospital Abuja, Abuja, Nigeria, 2Jos University Teaching Hospital, Jos, and etiology globally and highlight work of the International Emerging Nigeria Infections Programs, a U.S. CDC network of sites around the world with a standardized approach to pneumonia surveillance and diagnostics. This multi- 1:45 p.m. country approach to conducting population-based pneumonia surveillance and etiology studies will be explored by discussing standard approaches 303 to surveillance, including case defi nitions and diagnostics, comparative incidence and pathogen discovery for novel agents that may be associated with EFFECT OF THE A-FORM OF G6PD DEFICIENCY ON pneumonia. MATERNAL PLASMODIUM FALCIPARUM PARASITEMIA AND PREGNANCY OUTCOMES CHAIR Ella T. Nkhoma1, Jianbing Mu2, Michael A. Krause2, Seidina A. Diakite3, Sonja J. Olsen Linda Kalilani4, Stephen J. Rogerson5, Rick M. Fairhurst2, Steven R. Centers for Disease Control and Prevention, Atlanta, GA, United States Meshnick1 Orin S. Levine 1University of North Carolina-Chapel Hill, Chapel Hill, NC, United States, 2Laboratory Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States, 3Department of 1:30 p.m. Immunogenetics, University of Bamako, Bamako, Mali, 4College of Medicine, University 5 PNEUMONIA ETIOLOGY RESEARCH FOR CHILD of Malawi, Blantyre, Malawi, Department of Medicine, University of Melbourne, Parkville, Australia HEALTH: PREPARING FOR A WORLD AFTER HIB AND PNEUMOCOCCAL VACCINATION 2 p.m. Orin S. Levine Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States 304 Thursday, November 19 1:55 p.m. A COMPARISON OF IRON AND FOLATE WITH FOLATE STANDARDIZED APPROACHES TO PNEUMONIA ALONE IN HEMATOLOGIC RECOVERY OF CHILDREN SURVEILLANCE AND COMPARATIVE ETIOLOGIC DATA TREATED FOR ACUTE MALARIA IN THE IEIPS Samuel N. Gara1, Aboi J. Madaki1, Tom D. Thacher2 1 2 Kip Baggett Jos University Teaching Hospital, Jos, Nigeria, Mayo Clinic, Rochester, MN, United Centers for Disease Control and Prevention, Bangkok, Thailand States 2:20 p.m. 2:15 p.m. SUPPORTING DIAGNOSTIC LABORATORIES IN REMOTE 305 LOCATIONS: THE IEIP EXPERIENCE Barry S. Fields IMPROVED MALARIA CASE MANAGEMENT FOLLOWING Centers for Disease Control and Prevention, Atlanta, GA, United States DISTRICT BASED INTEGRATED TEAM TRAINING AND SUPPORT SUPERVISION OF HEALTH CARE WORKERS 2:45 p.m. IN UGANDA CHARACTERIZATION OF NOVEL AND UNRECOGNIZED Umaru B. Ssekabira1, Dan Senjovu Kaggwa1, Alex Ojaku1, Patrick Eyul1, PATHOGENS: PATHOGEN DISCOVERY APPROACHES IN Adoke Yeka2, Priscilla Aquilla Omwangangye3, Allen Namagembe1, Samuel PNEUMONIA ETIOLOGY STUDIES Ocan1, John Bosco Rwakimari4, Lydia Mpanga Sebuyira3, Marcia R. Weaver5 1 2 David Wang Joint Uganda Malaria Training Programme, Kampala, Uganda, Infectious Diseases 3 Washington University School of Medicine, St. Louis, MO, United States Research Collaboration, Kampala, Uganda, Infectious Diseases Institute of Makerere University, Kampala, Uganda, 4Uganda Ministry of Health, Malaria Control 5 Scientifi c Session 36 Programme, Kampala, Uganda, University of Washington, Seattle, WA, United States 2:30 p.m. Clinical Tropical Medicine I 306 Washington 1 Thursday, November 19, 1:30 p.m. - 3:15 p.m. DISPARITIES EXIST IN THE AVAILABILITY OF MALARIA TREATMENT IN THE U.S. CHAIR Kelly A. Bear, Amanda Higginson, Patrick Hickey Ella T. Nkhoma Uniformed Services University of the Health Sciences, Bethesda, MD, United States University of North Carolina-Chapel Hill, Chapel Hill, NC, United States Priscilleyne O. Reis Ministry of Health, Brasilia, Brazil

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2:45 p.m. 1:55 p.m. RESEARCH CAPACITY STRENGTHENING IN ACTION AT 307 MAKERERE UNIVERSITY PROSPECTIVE STUDY ON CO-INFECTION OF COMMON Eli Katunguka Makerere University, Kampala, Uganda VIRAL RESPIRATORY PATHOGENS AND MALARIA IN YOUNG CHILDREN IN PAPUA NEW GUINEA 2:20 p.m. Patricia Rarau, Mary Salib, Doris Manong, Brenda Wingi, Jennifer Igu, Ivo CREATION OF AN NEW NON-GOVERNMENTAL Mueller, Nicolas Senn Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea NATIONAL HEALTH RESEARCH BODY IN KENYA Gilbert Kokwaro 3 p.m. Consortium for National Health Research, Nairobi, Kenya

308 2:45 p.m. HEALTH RESEARCH CAPACITY BUILDING IN AFRICA - INVESTIGATION OF CONTACTS OF A SOUTH AFRICAN CHALLENGES AND MODELS TRAVELER WITH INITIALLY SUSPECTED ARENAVIRUS Marcel Tanner INFECTION, RIO DE JANEIRO, BRAZIL, 2008 Swiss Tropical Institute, Basel, Switzerland Priscilleyne O. Reis1, Dalva M. Assis1, Alessandra V. Cardoso2, Cecília C. Nicolai3, Guida Silva4, Ligia M. Costa5, Elba R. Lemos6, Márcio H. Garcia7, Scientifi c Session 38 Wildo N. Araújo1, Eduardo H. Carmo8 1Brazilian Field Epidemiology Training Program (EPISUS), Secretariat of Health Surveillance, Ministry of Health, Brasília, Brazil, 2Respiratory an Vaccine Preventable Cestodes and Intestinal Nematodes Disease Branch, Ministry of Health, Brasília, Brazil, 3Municipal Secretariat of Health, Rio de Janeiro, Brazil, 4State Secretariat of Health and Civil Defense, Rio de Janeiro, Washington 3 Brazil, 5Directorate of Public Health Laboratories, Ministry of Health, Brasília, Brazil, Thursday, November 19, 1:30 p.m. - 3:15 p.m. 6Department of Virology, Oswaldo Cruz Institute, Ministry of Health, Brasília, Brazil, 7Center for Strategic Information in Health Surveillance, Ministry of Health, Brasília, CHAIR 8 Brazil, Department of Epidemiological Surveillance, Secretariat of Health Surveillance, Siddhartha Mahanty Ministry of Health, Brasília, Brazil National Institutes of Health, Rockville, MD, United States Patricia Wilkins Symposium 37 Centers for Disease Control and Prevention, Atlanta, GA, United States

Health Research Capacity Strengthening: Wellcome Trust 1:30 p.m. Experiences 309 Washington 2 Thursday, November 19, 1:30 p.m. - 3:15 p.m. A RAT MODEL OF INTRACEREBRAL INFECTION WITH TAENIA CRASSICEPS FOR THE STUDY OF INFLAMMATION The need for increased health research capacity strengthening in developing ASSOCIATED WITH ANTHELMINTIC THERAPY IN countries is increasingly accepted. The Wellcome Trust, a major UK- NEUROCYSTICERCOSIS based independent research-funding charity, has recently launched three innovative, yet contrasting, schemes aimed at addressing some of these needs, Siddhartha Mahanty, Abby L. Berns, Erick Scott, Martin Lizak, Theodore in response to county-led demand, in India and Africa. The Indian Alliance Nash National Institutes of Health, Rockville, MD, United States (IA) scheme was launched in 2008 to support research capacity strengthening through a new within-country body to award fellowships nationally. The 1:45 p.m. Health Research Capacity Strengthening (HRCS) scheme and the African Institutions Initiative were both launched in 2009. The HRCS is supporting health research funding bodies in Malawi and Kenya to implement national 310 programs of training and grant support. The African Institutions Initiative is supporting networks of universities and research institutions across Africa, A MULTI-ANTIGEN PRINT IMMUNOASSAY (MAPIA) FOR and with northern partners, to increase African research capacity through a DETECTION OF TAENIA SOLIUM CYSTICERCOSIS AND variety of research management, training, and mentoring schemes. TAENIASIS ANTIBODIES Sukwan Handali1, Molly Klarman2, Amanda N. Gaspard3, John Noh1, CHAIR Yeuk-mui Lee1, Silvia Rodriguez4, Armando E. Gonzalez5, Hector H. Garcia6, Jimmy Whitworth Robert Gilman7, Victor C. Tsang8, Patricia P. Wilkins1 Wellcome Trust, London, United Kingdom 1Centers for Disease Control and Prevention, Chamblee, GA, United States, 2Rollins 3 Barbara Sina School of Public Health, Emory University, Atlanta, GA, United States, Rollins School 4 Fogarty International Center, Bethesda, United States of Public Health, Emory University, Atlanta, GA, United States, Cysticercosis Unit, Instituto de Ciencias Neurologicas, Lima, Peru, 5School of Veterinarian Medicine, 1:30 p.m. Universidad de San Marcos, Lima, Peru, 6Department of Microbiology, Universidad Peruana Cayetano, Lima, Peru, 7Bloomberg School of Public Health, Johns Hopkins THE VISION FOR CAPACITY BUILDING IN INDIA University, Baltimore, MD, United States, 8Department of Biology, Georgia State Anuradha Lohia University, Atlanta, GA, United States Wellcome/DBT India Alliance, Hydrobad, India

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2 p.m. 3 p.m.

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EPILEPTIC SEIZURES IN POPULATION FROM ENDEMIC RELATIVE EFFECTIVENESS OF TWO ANTIHELMINTIC AND NON-ENDEMIC AREAS FOR CYSTICERCOSIS REGIMENS TO CONTROL SOIL-TRANSMITTED Isidro Gonzalez1, Jaime Miranda2, Silvia Rodriguez2, Candice Romero2, Juan HELMINTH INFECTIONS AMONG PRE-SCHOOL AGED F Chiroque2, Victor Vargas1, Alfredo Cjuno1, Javier A. Bustos2, Hector H. CHILDREN IN BANGLADESH 2 Garcia 1 2 2 1 1 2 Cynthia Snider , Masud Alam , Dinesh Mondal , William A. Petri, Jr. , Instituto de Ciencias Neurologicas, Lima, Peru, Universidad Peruana Cayetano Rashidul Haque2 Heredia, Lima, Peru 1University of Virginia, Charlottesville, VA, United States, 2International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh 2:15 p.m.

312 Scientifi c Session 39

EVALUATION OF NEW SEROLOGIC TECHNIQUES FOR American Committee of Molecular, Cellular and THE DIAGNOSIS OF STRONGYLOIDES STERCORALIS Immunoparasitology (ACMCIP): Cellular Parasitology I INFECTIONS Alejandro J. Krolewiecki1, Roshan Ramanathan2, Valeria Fink3, Kimberly Supported with funding from the Burroughs Wellcome Fund Won4, Silvana Cajal1, Marisa Juarez1, Norma Acosta1, Rogan Lee5, Patrick Lammie4, David Abraham6, Thomas Nutman2 Washington 4 1Instituto de Investigaciones en Enfermedades Tropicales, Oran, Argentina, 2Laboratory Thursday, November 19 1:30 p.m. - 3:15 p.m. of Parasitic Diseases, National Institutes of Health, Bethesda, MD, United States, 3 4 Fundacion Huesped, Buenos Aires, Argentina, Division of Parasitic Diseases, CHAIR Centers for Disease Control and Prevention, Atlanta, GA, United States, 5Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Australia, James G. Beeson 6Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Walter and Eliza Hall Institute of Medical Research, Parkville, Australia Jefferson University, Philadelphia, PA, United States Charles Cunningham University of New Mexico, Albuquerque, NM, United States 2:30 p.m. 1:30 p.m.

313 Thursday, November 19 KEYNOTE ADDRESS: CELLULAR PARASITOLOGY QUANTITATIVE PCR-BASED ASSESSMENT OF 1:45 p.m. ANGIOSTRONGYLUS CANTONENSIS LARVAE BURDEN IN U.S. ENVIRONMENTAL SAMPLES 1147 Yvonne Qvarnstrom1, Henry Bishop2, John Teem3, Robert Hollingsworth4, Sarah Y. Park5, Arlene Buchholz5, Alexandre J. da Silva2 REVERSE GENETIC ANALYSIS OF ERYTHROCYTE 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Centers for DETERMINANTS OF PLASMODIUM FALCIPARUM INVASION Disease Control and Prevention-NCZVED-Division of Parasitic Diseases, Atlanta, Amy K. Bei1, Carlo Brugnara2, Manoj T. Duraisingh1 GA, United States, 3Division of Aquaculture, Florida Department of Agriculture and 1Harvard School of Public Health, Boston, MA, United States, 2Children’s Hospital Consumer Services, FL, United States, 4United States Pacifi c Basin Agricultural Boston, Boston, MA, United States Research Center, United States Department of Agriculture, Hilo, HI, United States, 5Hawaii State Department of Health, Honolulu, HI, United States (ACMCIP Abstract) 2 p.m. 2:45 p.m. 316 314 PERINUCLEAR PROTEIN, P. FALCIPARUM EPIDEMIOLOGY OF HOOKWORM INFECTION IN GAMETOCYTOGENESIS INDUCER 1, PFGYI1, PLAYS AN KINTAMPO NORTH DISTRICT, CENTRAL GHANA IMPORTANT ROLE IN GAMETOCYTOGENESIS 1 1 2 Debbie Humphries1, Emily Mosites1, Joseph Otchere2, Amoani Twum2, Saliha Eksi , Yoseph Haile1, Belinda J. Morahan , Tetsuya Furuya , 1 2 2 1 Lauren Woo1, Hinckley Jones-Sanpei3, Lisa Harrison1, Richard D. Bungiro4, Amreena Suri , Hongying Jiang , Xinzhuan Su , Kim C. Williamson Michael Wilson2, Kwabena Bosompem2, Michael Cappello1 1Loyola University Chicago, Chicago, IL, United States, 2National Institutes of Health, 1Yale University, New Haven, CT, United States, 2Noguchi Memorial Institute for Bethesda, MD, United States Medical Research, Accra, Ghana, 3University of North Carolina, Chapel Hill, NC, United States, 4Brown University, Providence, RI, United States

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2:15 p.m. Symposium 40 317 American Committee of Medical Entomology (ACME) I- A METHOD FOR IN VITRO PRODUCTION OF P. Space Repellents: Potential for Role in Reducing Vector- FALCIPARUM OOKINETES REVEALS NOVEL INSIGHTS Borne Disease INTO OOKINETE BIOLOGY Washington 5 Viengngeun Bounkeua, Fengwu Li, Joseph M. Vinetz Thursday, November 19, 1:30 p.m. - 3:15 p.m. University of California, San Diego, La Jolla, CA, United States Quantifying and accurately describing behavioral responses of mosquitoes 2:30 p.m. to insecticides is of paramount importance for understanding the impact specifi c behaviors will have on the risk of disease transmission. As early 318 as 1953, Muirhead-Thomson concluded that contact between humans and disease-transmitting mosquitoes could be disrupted in such a way as to stop CELLULAR AND MOLECULAR INTERACTIONS WITH disease transmission without killing the mosquitoes. One behavioral action HEPARIN-LIKE MOLECULES DURING INVASION that has been documented and is of great importance is spatial repellency. The use of space repellents to prevent vectors from entering structures or OF ERYTHROCYTES BY PLASMODIUM FALCIPARUM areas inhabited by human hosts using levels of chemicals that do not elicit a MEROZOITES selection pressure for resistance (toxicity) has broad implications for disease Michelle Boyle1, Jack S. Richards1, Paul R. Gilson2, Wengang Chai3, James control programs worldwide. The emphasis on toxicity has dominated the G. Beeson1 search and development of new chemistries for insect control; however, with 1Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, 2Macfarlane the increasing pressure of insecticide resistance, a refocus to other chemical Burnet Institute for Medical Research and Public Health, Melbourne, Australia, actions will be necessary to drive the development of innovative vector control 3Glycosciences Laboratory, Imperial College London, Northwick Park and St. Mark’s strategies. Campus, Harrow, United Kingdom CHAIR 2:45 p.m. John Grieco Uniformed Services University of the Health Sciences, Bethesda, MD, United States 319 Richard Andre Uniformed Services University of the Health Sciences, Bethesda, MD, United States THE INFLUENCE OF PAIRING ON GENE EXPRESSION OF SCHISTOSOMA MANSONI ADULT FEMALES 1:30 p.m. Giulliana T. Almeida1, Thiago M. Venancio1, Ricardo DeMarco2, Sergio DDT: ROLE OF REPELLENT ACTIONS TO CONTROL Verjovski-Almeida1 MALARIA 1 Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Sao Donald Roberts 2 Paulo, Brazil, Departamento de Física e Informática, Instituto de Fisica de São Carlos- Uniformed Services University of the Health Sciences, Bethesda, MD, United States Universidade de São Paulo, São Carlos, Brazil 1:55 p.m. 3 p.m. A LOCOMOTORY STIMULATION MODEL FOR EXCITO- 320 REPELLENCY PHENOMENA Edward D. Walker UNDERSTANDING THE BIOLOGY OF SCHISTOSOMES Michigan State University, East Lansing, MI, United States IN RESPONSE TO PRAZIQUANTEL 2:20 p.m. Pauline M. Cupit1, Anthony D. Aragon1, Tinopiwa Goronga2, Thomas R. Webb2, Charles Cunningham1 THE ROLE OF MODELING IN THE EVALUATION OF 1University of New Mexico, Albuquerque, NM, United States, 2St. Jude Children’s SPATIAL REPELLENTS Research Hospital, Memphis, TN, United States Fredros Okumu Ifakara Health Institute, Dar es Salaam, Tanzania 2:45 p.m. COMPOUNDS THAT INHIBIT THE INSECT HOST- SEEKING ABILITY TO HUMAN Ulirich R. Bernier USDA-ARS-CMAVE, Gainsville, FL, United States

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Symposium 40A Symposium 41

Urbanization and Typhoid Fever in Asia and Africa: A Time Immune Evasion in Malaria: A Challenge for Vaccine for Prevention Development Wilson AB Salon 1 Thursday, November 19, 1:30 p.m. – 3:15 p.m. Thursday, November 19, 3:45 p.m. - 5:30 p.m.

The incidence of bacteremic typhoid fever has been shown to be exceedingly Malaria is a deadly infectious disease that affects one-to-two billion people and high in children in Asia, especially within urban informal settlements, and in kills up to one million children yearly. Despite decades of intensive research, one urban informal settlement in Africa. Rising antimicrobial resistance of we are still lacking an effective vaccine against malaria. Our efforts are being circulating S. Typhi strains and high rates of invasive disease in young children challenged not only by the complexity of Plasmodium’s life cycle, but also suggest that strategies for prevention, like immunization, may be worth by the parasite’s masterful ability to avoid clearance by the host innate and pursuing, especially for children in densely populated urban environments adaptive immune responses. This symposium will review the main mechanisms where water sanitation and hygiene are suboptimal. Progress in improving of immune evasion used by malaria parasites, namely antigenic variation and diagnostics and an array of existing and new vaccine formulations make the use of alternative erythrocyte invasion pathways, as well as subversion of control and prevention of typhoid increasingly feasible, but would require host dendritic cells and regulatory T cell function. The implications that the prioritization among governments in the developing world, international health parasite’s immune evasion mechanisms have for vaccine development will be agencies and donors. This symposium presents recent data on disease burden discussed. and reviews the potential for prevention with existing and future-candidate vaccines. CHAIR Sofi a Casares CHAIR Naval Medical Research Center/Walter Reed Army Institute of Research, Silver Spring, Robert F. Breiman MD, United States Centers for Disease Control and Prevention-Kenya, Nairobi, Kenya Thomas L. Richie CHAIR Naval Medical Research Center/Walter Reed Army Institute of Research, Silver Spring, MD, United States W. Abdullah Brooks International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh 3:45 p.m. 1:30 p.m. VARIANT EXPRESSION IN PLASMODIUM FALCIPARUM: TYPHOID FEVER--AN URBAN PROBLEM BEYOND VAR GENES Alfred Cortes Thursday, November 19 W. Abdullah Brooks ICREA , Institut de Recerca Biomedica, Barcelona, Spain International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh 1:55 p.m. 4:10 p.m. URBANIZATION AND THE BURDEN OF TYPHOID FEVER MOLECULAR AND CELLULAR MECHANISM OF T CELL IN AFRICA MEDIATED IMMUNE EVASION IN MALARIA Magdalena Plebanski Robert F. Breiman Monash University, Victoria, Melbourne, Australia Centers for Disease Control and Prevention-Kenya, Nairobi, Kenya 2:20 p.m. 4:35 p.m. P. FALCIPARUM EFFECTIVENESS OF TYPHOID IMMUNIZATION IN AN REGULATORY T CELLS IN MALARIA: URBAN INFORMAL SETTLEMENT IN KOLKATA ARE THEY RELEVANT FOR DISEASE OUTCOME AND VACCINE DESIGN? Dipika Sur National Institute of Cholera and Enteric Diseases, Kolkata, India Michael Walther Malaria Programme Medical Research Council Laboratories, Fajara, Banjul, Gambia 2:45 p.m. 5 p.m. ON THE CUTTING-EDGE OF TYPHOID VACCINE DEVELOPMENT URIC ACID-INDUCED INFLAMMATION AND IMMUNE REGULATION IN MALARIA Audino Podda Novartis Vaccines Institute for Global Health (NVGH), Siena, Italy Ana Rodriguez New York University, New York, NY, United States

Exhibit Hall Open Exhibit Hall A Thursday, November 19, 3 p.m. - 4 p.m. Coffee Break Exhibit Hall A Thursday, November 19, 3:15 p.m. - 3:45 p.m.

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Symposium 41A 5 p.m. MORTALITY BURDEN AND NUTRITIONAL Surprising Insights on Diarrheal Disease, One of the CONSEQUENCES EXTEND BEYOND THE ACUTE Top Two Causes of Young Child Mortality in Developing DIARRHEAL EPISODE Countries Dilruba Nasrin University of Maryland School of Medicine, Baltimore, MD, United States Salon 2 Thursday, November 19, 3:45 p.m. - 5:30 p.m. Symposium 42

Diarrheal diseases constitute the second most common cause of death among children less than fi ve years of age in the developing world. To achieve UN Geospatial Patterns of Disease in a Changing Climate Millennium Development goal #4 (to decrease “under-fi ves” mortality by Salon 3 67% by 2015 compared to the 1990 baseline), progress will have to be made in controlling diarrheal disease mortality. To accomplish this goal, some Thursday, November 19, 3:45 p.m. - 5:30 p.m. critical activities will have to ensue, including: estimating more precisely the Climate change projections indicate major alterations will occur in the diarrheal mortality burden; identifying the most important etiologic agents distribution patterns and abundance of tropical diseases by 2030. Changing associated with diarrheal mortality; investigating the risk and protective climate scenarios will be discussed for mosquito-borne diseases (malaria, factors for transmission of important diarrheal agents; and, assessment of the Rift Valley Fever), Chagas disease in the U.S. and schistosomiasis and other impact of programmatic use of existing vaccines (e.g., rotavirus vaccines). tropical diseases in China. This symposium will: 1) review application of state-of-the-art diagnostic methods, as well as more classical methods, to identify a wide array of known CHAIR diarrheal pathogens and to incriminate possible new pathogens; 2) summarize the latest results of a multi-center population-based case/control study of the John B. Malone etiology of severe diarrhea among children less than fi ve years of age and Louisiana State University, Baton Rouge, LA, United States population-based estimates of pathogen-specifi c incidence in four sites in Robert Bergquist sub-Saharan Africa and three in South Asia; 3) review epidemiologic data on Geospatial Health, Brastad, Sweden water and sanitation conditions and human behaviors that constitute risk and protective factors (and that emphasize the surprising site-specifi city of many 3:45 p.m. of these factors); 4) reviewed data from 60-day visits to the households of RIFT VALLEY FEVER EPIDEMICS: DYNAMICS AND RISK pediatric diarrhea cases and controls that detect a notable mortality burden evident among children who suffered an episode of diarrhea, even many MAPPING days and weeks after resolution of the acute diarrheal episode. Collectively, Yves M. Tourre these new microbiologic and epidemiologic fi ndings are providing heretofore MEDIAS-France and LDEO of Columbia University, Ramonville Saint-Agne, France unappreciated insights into the public health problem of severe diarrhea among infants and children in developing countries. 4:10 p.m. CLIMATE CHANGE AND TROPICAL DISEASES IN CHINA CHAIR Xiaonong Zhou Myron M. Levine Institute of Parasitic Diseases - China Centers for Disease Control and Prevention, University of Maryland School of Medicine, Baltimore, MD, United States Shanghai, China Jan Agosti Bill and Melinda Gates Foundation, Seattle, WA, United States 4:35 p.m. 3:45 p.m. THE ROLE OF CLIMATE IN THE POTENTIAL EMERGENCE OF CHAGAS DISEASE IN THE UNITED DIAGNOSTICS FOR ENTERIC PATHOGENS: DILEMMAS STATES AND DELIGHTS Korine N. Kolivras James P. Nataro Virginia Polytechnic Institute and State University, Blacksburg, VA, United States University of Maryland School of Medicine, Baltimore, MD, United States 5 p.m. 4:10 p.m. CLIMATE CHANGE AND MOSQUITOES: SHRINKING THE ETIOLOGY AND BURDEN OF MODERATE AND SEVERE MALARIA MAP AND BOOSTING ARBOVIRUSES PEDIATRIC DIARRHEAL DISEASE IN AFRICA AND ASIA Archie Clements Karen L. Kotloff University of Queensland, Townsville, Australia University of Maryland School of Medicine, Baltimore, MD, United States 4:35 p.m. LIMITATIONS OF “ONE-SIZE INTERVENTIONS”: RISKS AND PROTECTIVE FACTORS FOR TRANSMISSION OF DIARRHEAL PATHOGENS VARY MARKEDLY AMONG SITES Myron M. Levine University of Maryland School of Medicine, Baltimore, MD, United States

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Symposium 43 Symposium 44

Ancillary Benefi ts of Azithromycin Mass Treatment for Rapid Diagnostics For Low-Resource Settings Trachoma on Malaria, Diarrhea, Respiratory Infection and Delaware B Sexually Transmitted Infections in Tanzania Thursday, November 19, 3:45 p.m. - 5:30 p.m. Delaware A This symposium will present the current status and potential development of Thursday, November 19, 3:45 p.m. - 5:30 p.m. affordable rapid diagnostics for the evaluation of TB, malaria, leishmaniasis, trypanosomiasis and STDs in resource poor environments. Azithromycin mass treatment of entire villages with more than 10% prevalence of trachoma in children is standard for trachoma national control programs. CHAIR Not only is azithromycin effective for C. trachomatis, but also azithromycin is active against organisms responsible for malaria, acute respiratory illness, Mark Paris diarrhea and sexually transmitted infections. This symposium will present Palm Beach County Department of Health, Delray Beach, FL, United States fi ndings on the extent and persistence of the ancillary benefi ts of single dose Robert Gilman azithromycin in a six-month community prevalence study of more than Johns Hopkins University, Baltimore, MD, United States 2,000 people in eight villages of malaria and trachoma endemic Tanzania. A GPS-based spatial-temporal analysis was performed after serial molecular 3:45 p.m. and culture detection of agents causing malaria, relapsing fever, diarrhea, DEVELOPING TB DIAGNOSTICS: THE HOPKINS respiratory infection and sexually transmitted infections. In addition, changes EXPERIENCE were assessed to antimicrobial susceptibility pattern to S. pneumoniae and fecal E. coli, as well as antimalarial drug-resistant genotypes in the six months David Moore following mass treatment. Universidad Peruano Cayetano Heredia, Lima, Peru

CHAIR 4:10 p.m. David J. Sullivan DIAGNOSTICS FOR MALARIA IN PREGNANCY Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United Michal Fried States Seattle Biomedical Research Institute, Seattle, WA, United States Sheila K. West Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 4:35 p.m. United States CURRENT STATUS OF LEISHMANIASIS/TRYPANOMIASIS 3:45 p.m. DIAGNOSTICS Thursday, November 19 Steve Reed ANCILLARY BENEFITS OF AZITHROMYCIN ON Infectious Disease Research Institute, Seattle, WA, United States MALARIA AND PLASMODIUM DRUG RESISTANCE IN TANZANIA 5 p.m. David J. Sullivan EVALUATING EMERGING TECHNOLOGIES FOR RAPID Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States DIAGNOSIS: ALIGNMENT OF PRODUCT PROFILES AND 4:10 p.m. IMPLEMENTATION STRATEGIES Wilbur Milhous MALARIA RAPID DIAGNOSTIC TEST IMPLEMENTATION University of South Florida, Tampa, FL, United States DURING MASS TREATMENT OF AZITHROMYCIN George Mtove 5:10 p.m. National Institute for Medical Research, Muheza, United Republic of Tanzania STD UPDATE: CAN WE MOVE BEYOND SYNDOMIC 4:30 p.m. TREATMENT? Rosanna Peeling ANCILLARY BENEFITS OF AZITHROMYCIN ON World Health Organization, Geneva, Switzerland NASOPHARYNGEAL CARRIAGE, RISK OF ACUTE LOWER RESPIRATORY INFECTION AND DIARRHEA Christian L. Coles Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States 4:50 p.m. DRUG RESISTANCE OF RESPIRATORY PATHOGENS FOLLOWING MASS TREATMENT WITH AZITHROMYCIN Mabula Kasubi Muhimbili National Hospital, Dar es Salaam, United Republic of Tanzania 5:10 p.m. ANCILLARY BENEFITS OF AZITHROMYCIN ON SEXUALLY TRANSMITTED DISEASES IN TANZANIA Charlotte Gaydos Johns Hopkins University School of Medicine, Baltimore, MD, United States

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Symposium 45 Symposium 46

Tracking Resistance to Antimalarial Drugs: Progress Mechanisms of Hantaviral Disease and Persistence Toward a Network Virginia C Virginia AB Thursday, November 19, 3:45 p.m. - 5:30 p.m. Thursday, November 19, 3:45 p.m. - 5:30 p.m. Hantaviruses, similar to several emerging zoonotic viruses, persistently The WorldWide Antimalarial Resistance Network, WWARN, will have been infect their natural reservoir hosts without causing overt signs of disease. in operation for about one year at the time of the 2009 ASTMH meeting. This Spillover to incidental human hosts results in morbidity and mortality symposium will focus on the tools being developed and collaborations that mediated by excessive proinfl ammatory and cellular immune responses. The are being established between scientists and public health experts in malaria mechanisms mediating differential viral pathogenesis in human and rodents endemic regions. are only starting to be uncovered and involve both viral and host-mediated mechanisms. Although advances are being made in the development of a CHAIR hantavirus vaccine, there currently is no FDA-approved vaccine or drug for prevention or treatment of hantaviral disease. Understanding the mechanisms Carol H. Sibley mediating viral pathogenesis in both humans and rodent reservoirs may WorldWide Antimalarial Resistance Network, Seattle, WA, United States contribute to advances in the treatment of hantaviral disease in humans. Kumar V. Udhayakumar Centers for Disease Control and Prevention, Atlanta, GA, United States CHAIR 3:45 p.m. Sabra L. Klein Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States TOOLS FOR MANAGEMENT OF CLINICAL DRUG CHAIR EFFICACY Brian Hjelle Grant Dorsey University of New Mexico Health Science Center, Albuquerque, NM, United States Makerere University/University of California at San Francisco, Kampala/San Francisco, United States 3:45 p.m. 4:10 p.m. HANTAVIRUS N: REGULATOR OF VIRAL AND HOST RNA FUNCTION PHARMACOLOGY: A KEY COMPONENT OF ASSESSMENT OF DRUG EFFICACY Antonito T. Panganiban University of New Mexico, Albuquerque, NM, United States Karen I. Barnes University of Capetown, Capetown, South Africa 4:10 p.m. 4:35 p.m. IMMUNE RESPONSES TO NEW WORLD HANTAVIRUSES IN HUMANS MONITORING MALARIA DRUG RESISTANCE IN SOUTH AND CENTRAL AMERICA AS PART OF THE AMAZON Brian Hjelle University of New Mexico, Albuquerque, NM, United States MALARIA INITIATIVE Alexandre Macedo De Oliveira 4:35 p.m. Centers for Disease Control and Prevention, Atlanta, GA, United States IMMUNOLOGICAL EVENTS DURING SIN NOMBRE 5 p.m. VIRUS INFECTION OF DEER MICE INTEGRATED INFORMATION ON ANTIMALARIAL Tony Schountz University of Northern Colorado, Greeley, CO, United States RESISTANCE- TOOLS FOR PRESENTATION TO POLICYMAKERS 5 p.m. Philippe Guerin INDUCTION OF REGULATORY RESPONSES MEDIATES WWARN, Oxford, United Kingdom SEOUL VIRUS PERSISTENCE IN RATS Sabra L. Klein Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States Scientifi c Session 47

Clinical Tropical Medicine II Washington 1 Thursday, November 19, 3:45 p.m. - 5:30 p.m.

CHAIR Ana A. Weil International Center for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh

Richard Ssekitoleko Mbarara University, Mbarara, Uganda

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3:45 p.m. 5 p.m.

321 326

INVESTIGATION OF AN OUTBREAK OF SUPPOSED RE-EMERGENCE OF CHIKUNGUNYA FEVER IN LEPTOSPIROSIS IN PEDRO CANÁRIO, ESPÍRITO SANTO NARATHIWAT PROVINCE: A STUDY ON CLINICAL STATE, BRAZIL, JANUARY, 2009 MANIFESTATIONS Verena M. Souza1, Juliano L. Hoffmann1, Maxwell Marchito2, Wildo N. Thongchai Lertwilairatanapong, Jariya Narathipput, Suvimon Heng Araújo1 Narathiwat Provincial Health Offi ce, Narathiwat, Thailand 1Ministry of Health, Brasilia, Brazil, 2Secretariat of Health of Espírito Santo State, Vitória, Brazil 5:15 p.m.

4 p.m. 327

322 DIABETIC RETINOPATHY IN AN URBAN DIABETIC CLINIC IN MALAWI HYPOGLYCEMIA IS ASSOCIATED WITH MORTALITY IN Simon J. Glover, Theresa J. Allain, Danielle B. Cohen UGANDAN PATIENTS WITH SEVERE SEPSIS College of Medicine, Blantyre, Malawi Richard Ssekitoleko1, Christopher C. Moore2, Shevin T. Jacob3, Relana Pinkerton2, Patrick Banura4, David Meya5, Steven J. Reynolds6, Nathan Symposium 48 Kenya-Mugisha7, Harriet Mayanja-Kizza5, W. Michael Scheld2 1Mbarara University, Mbarara, Uganda, 2University of Virginia, Charlottesville, VA, United States, 3University of Washington, Seattle, WA, United States, 4Masaka Keys to Success in Global Health Partnership Regional Referral Hospital, Masaka, Uganda, 5Makerere University, Kampala, Uganda, 6National Institutes of Health, Bethesda, MD, United States, 7Ministry of Health, Washington 2 Kampala, Uganda Thursday, November 19, 3:45 p.m. - 5:30 p.m.

4:15 p.m. A partnership between Indiana University School of Medicine and Moi University School of Medicine in western Kenya has grown over 20 years 323 from a program of limited size into one of the largest and most comprehensive HIV/AIDS control systems in sub-Saharan Africa. With the involvement of CLINICAL OUTCOMES IN HOUSEHOLD CONTACTS OF several other North American academic institutions, the partnership is now Thursday, November 19 PATIENTS WITH CHOLERA IN BANGLADESH expanding beyond HIV/AIDS and tackling a wide range of health issues, including electronic medical records, income and food security, primary care 1 1 1 2 Ana A. Weil , Ashraful I. Khan , Fahima Chowdhury , Regina C. LaRocque , and public health. The partnership’s emphasis on fostering the tri-partite 1 2 2 1 A. S. Faruque , Edward T. Ryan , Stephen B. Calderwood , Firdausi Qadri , academic mission, its focus on health systems and institutional development, 2 Jason B. Harris and its long-term commitment to empowering individual Kenyans through 1 International Center for Diarrheal Disease and Research, Bangladesh, Dhaka, counterpart relationships distinguish the twinning model. This symposium Bangladesh, 2Massachusetts General Hospital, Boston, MA, United States will discuss the key elements of this successful partnership, paying particular 4:30 p.m. attention to those elements that make this partnership highly relevant to the fi eld of global health and highly replicable among other academic medical centers in the United States and sub-Saharan Africa. 324 CHAIR OUTBREAK OF MASS SOCIOGENIC ILLNESS IN James W. Smith SECONDARY SCHOOLS IN BANGLADESH ASSOCIATED Indiana University, Indianapolis, IN, United States WITH MEDIA COVERAGE AND PERSON-TO-PERSON DeVon C. Hale TRANSMISSION University of Utah School of Medicine, Salt Lake City, UT, United States Emily S. Gurley1, Mahmudur Rahman2, Nazmun Nahar1, M. Jahangir Hossain1, Rebeca Sultana1, Nadia Ali Rimi1, M. Saiful Islam1, Main Uddin1, 3:45 p.m. Dawlat Khan1, Mushtuq Husain2, Musleh Uddin2, Shamsi A. Chowdhury2, LEADING WITH CARE: BALANCING THE TRIPARTITE Nuzhat N. Banu2, Stephen P. Luby1 1International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, MISSION OF ACADEMIC MEDICINE 2Institute for Epidemiology, Disease Control and Research, Dhaka, Bangladesh Robert Einterz Indiana University, Indianapolis, IN, United States 4:45 p.m. 4:10 p.m. 325 A KENYAN PERSPECTIVE ON WHAT MAKES AN AMERICAN PARTNER COMPATIBLE AND SUCCESSFUL SPATIAL PATTERNS OF MENINGITIS IN NIGER Sylvester Kimaiyo 1 2 3 4 1 Nita Bharti , Helene Broutin , Rebecca Grais , Ali Djibo , Bryan Grenfell Moi University School of Medicine, Eldoret, Kenya 1Penn State University, University Park, PA, United States, 2Fogarty International Center, National Institutes of Health, Bethesda, MD, United States, 3Epicentre, Paris, France, 4Direction Generale de la Sante Publique, Ministere de la Sante, Niamey, Niger

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4:35 p.m. 4:30 p.m. THE ASANTE CONSORTIUM: HOW NORTH AMERICAN 331 HEALTH CENTERS CAN COOPERATE TO ACHIEVE COMMON GOALS IN GLOBAL HEALTH A RODENT MODEL OF LYMPHATIC PATHOLOGY DUE DeVon Hale TO ADULT FILARIAL WORMS University of Utah School of Medicine, Salt Lake City, UT, United States Charles D. Mackenzie1, Allison Eavey1, Tiffany Weinkopff2, Pat Lammie2, 5 p.m. Timothy Geary3 1Michigan State University, East Lansing, MI, United States, 2Centers for Disease THE AMPATH MEDICAL RECORD SYSTEM—A Control and Prevention, Atlanta, GA, United States, 3McGill University, Montreal, QC, FUNDAMENTAL TOOL FOR RESEARCH AND CARE AND Canada A TIE THAT BINDS INSTITUTIONS (ACMCIP Abstract) Martin Were 4:45 p.m. Indiana University School of Medicine, Indianapolis, IN, United States 332 Scientifi c Session 49 HIGH DOSE BIANNUAL ALBENDAZOLE AND Filariasis - Pathology/Treatment IVERMECTIN SUPPRESS WUCHERERIA BANCROFTI MICROFILARIAL LEVELS MORE EFFECTIVELY THAN Washington 3 STANDARD DOSE ANNUAL TREATMENT Thursday, November 19, 3:45 p.m. - 5:30 p.m. Yaya I. Coulibaly1, Benoit Dembele1, Siaka Konate1, Housseini Dolo1, Siaka CHAIR Y. Coulibaly1, Dramane Sanogo1, Lamine Soumaoro1, Michel E. Coulibaly1, Salif S. Doumbia1, Abdallah A. Diallo1, Sekou F. Traore1, Adama D. Keita2, Kelly L. Johnston Thomas B. Nutman3, Amy D. Klion3 Liverpool School of Tropical Medicine, Liverpool, United Kingdom 1University of Bamako, Bamako, Mali, 2Hospital of Point G, Bamako, Mali, 3National Moses N. Katabarwa Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Carter Center, Emory University, Atlanta, GA, United States MD, United States 3:45 p.m. 5 p.m.

328 333

CORRELATION OF DERMATOLOGICAL SCREENING OF APPROVED DRUGS FOR EFFICACY AND OPHTHALMOLOGICAL MORBIDITY IN AGAINST THE WOLBACHIA ENDOSYMBIONT OF ONCHOCERCIASIS (FOREST TYPE) FILARIAL NEMATODES Luc E. Coffeng1, Wilma A. Stolk1, Sake J. de Vlas1, Michel Boussinesq2, Kelly L. Johnston1, Indira Umareddy2, Florence Feby Cahya2, Ralf Grace N.A. Fobi2, Gladys A. Ozoh2, Peter A. Enyong2, Anne-Cécile Z.K. Altmeyer2, Mark J. Taylor1 Bissek2, Dik J.D.F. Habbema1 1Liverpool School of Tropical Medicine, Liverpool, United Kingdom, 2CombinatoRx 1Erasmus Medical Center, Rotterdam, The Netherlands, 2African Programme for Singapore, Helios, Singapore Onchocerciasis Control, Ouagadougou, Burkina Faso 4 p.m. Scientifi c Session 50

329 American Committee of Molecular, Cellular and Immunoparasitology (ACMCIP): Molecular Parasitology I PATIENT TREATMENT COSTS FOR MANAGEMENT OF LYMPHEDEMA AND ACUTE ATTACKS IN TOGO Supported with funding from the Burroughs Wellcome Fund Paul T. Cantey1, Stephanie Richard2, Stephanie Richard3, Ameyo Dorkenoo4, Washington 4 Yao Sodahlon5, Els Mathieu1 Thursday, November 19 3:45 p.m. - 5:30 p.m. 1Division of Parasitic Diseases, NCZVED, Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Fogarty International Center, Bethesda, MD, United CHAIR States, 3John Hopkins Bloomberg School of Public Health, Baltimore, MD, United May Ho States, 4Togo National Program for the Elimination of Lymphatic Filariasis, Lome, University of Calgary, Calgary, AB, Canada Togo, 5Mectizan Donation Program, Decatur, GA, United States Ajay D. Pillai 4:15 p.m. National Institutes of Health, Rockville, MD, United States 3:45 p.m. 330 KEYNOTE ADDRESS: MOLECULAR PARASITOLOGY THE WEST AFRICAN LF MORBIDITY PROJECT: TRAINING IN LF SURGERY AS AN AVENUE TO LYMPHATIC FILARIASIS ELIMINATION Anders R. Seim1, Sunny D. Mante2, Serigne M. Gueye3 1HDI (Health and Development International), Fjellstrand, Norway, 2Ghana Army Medical Corps, Accra, Ghana, 3University Cheikh Anta Diop, Dakar, Senegal

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4 p.m. 5 p.m.

1148 337

AN UNEXPECTED ROLE OF SIR2A IN THE LIFE CYCLE GENETIC VALIDATION OF THE PLASMODIAL SURFACE OF MALARIA PARASITES ANION CHANNEL AS AN ANTIMALARIAL DRUG TARGET Agnieszka A. Religa1, C. Carret2,3, T. Feltwell3, G. Hu4, A. Amaladoss4, M. Ajay D. Pillai, Sanjay A. Desai 5 3 4 4 5 1 Brochet , A. Pain , Z. Bozdech , P.R. Preiser , O. Billker , C.J. Janse , A. National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6 Scherf , A.P. Waters7 Rockville, MD, United States 1Malaria Group, Leiden University Medical Centre, Leiden, The Netherlands, 2Unidade de Malária, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal, 5:15 p.m. 3Pathogen Microarrays Group, The Wellcome Trust Sanger Institute, Cambridge, United Kingdom, 4School of Biological Sciences, Nanyang Technological University, Singapore, 338 5Sanger Malaria Programme, The Wellcome Trust Sanger Institute, Cambridge, United Kingdom, 6Biology of Host-Parasite Interactions Unit, Institut Pasteur, Paris, France, A UNIVERSAL APPROACH TO EXPRESS DIVERSE P. 7Division of Infection and Immunity, Faculty of Biological Life Sciences, University of Glasgow, Glasgow, United Kingdom FALCIPARUM ENZYMES IN FUNCTIONAL FORM Devaraja G. Mudeppa, Pradipsinh K. Rathod 4:15 p.m. University of Washington, Seattle, WA, United States 334

EXPRESSION OF PLASMODIUM FALCIPARUM Symposium 51 ERYTHROCYTE MEMBRANE PROTEIN 1 (PFEMP1) IS IRON-DEPENDENT American Committee of Medical Entomology (ACME) II- May Ho, Steven D. Beaudry, Aaron White, Kristine Lee, Takayuki Arie, Kirk Space Repellents: Field Evaluations of Current Products Deitsch, Rick M. Fairhurst and Strategies Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada, Laboratory of Malaria and Vector Research, National Institute of Washington 5 Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United Thursday, November 19, 3:45 p.m. - 5:30 p.m. States, Department of Microbiology and Immunology, Weill Medical College of Cornell Quantifying and accurately describing behavioral responses of mosquitoes to

University, New York, NY, United States Thursday, November 19 chemicals is of paramount importance for understanding the impact specifi c 4:30 p.m. behaviors will have on the risk of disease transmission. Many of our current vector control insecticides elicit behavioral actions from disease vectors. In 335 addition, a number of products are currently available that are marketed for repelling vectors from inside homes. This symposium will examine the HIGH POLYMORPHISM OF THE PF-SERCA IN fi eld based methodologies used for evaluating vector behavior and how PLASMODIUM FALCIPARUM FIELD ISOLATES these compounds and products alter this behavior. This symposium will also evaluate the role of these materials in reducing disease transmission. Ronan Jambou1, Axel Martinelli2, João Pinto2, Simonetta Gribaldo1, Eric Legrand3, Makhtar Niang4, Nimol Kim5, Béatrice Volnay3, Marie Thérèse CHAIR Ekala1, Christiane Bouchier1, Thierry Fandeur5, Pedro Berzosa6, Isabel Dinis Ferreira2, Cynthia Ferreira7, Pedro Paulo Vieira7, Maria das Graças Alecrim7, John Grieco Odile Mercereau-Puijalon1, Pedro Cravo2 Uniformed Services University of the Health Sciences, Bethesda, MD, United States 1Institut Pasteur, Paris, France, 2Centro de Malária e Outras Doenças Tropicais/IHMT/ Richard Andre UEI Biologia Molecular, Lisbon, Portugal, 3Institut Pasteur de Guyane Française, Uniformed Services University of the Health Sciences, Bethesda, MD, United States Cayenne, France, 4Institut Pasteur de Dakar, Dakar, Senegal, 5Institut Pasteur du Cambodge, Phnom Penh, Cambodia, 6Centro Nacional de Medicina Tropical, Madrid, 3:45 p.m. Spain, 7Fundação de Medicina Tropical do Amazonas, Manaus, Brazil TARGETED REPELLENCY: EVALUATION OF FOCAL TREATMENTS IN EXPERIMENTAL HUTS 4:45 p.m. Nicole Achee 336 Uniformed Services University of the Health Sciences, Bethesda, MD, United States 4:10 p.m. FYA/FYB ANTIGENIC POLYMORPHISM SIGNIFICANTLY ALTERS BINDING OF PLASMODIUM VIVAX DUFFY LONG-LASTING REPELLENT TREATED MATERIALS BINDING PROTEIN TO HUMAN ERYTHROCYTES FOR MALARIA PREVENTION IN DISASTERS AND EMERGENCIES Jia Xianli1, Brian Grimberg1, Asim A. Siddiqui1, Amy McHenry2, Lior Greenberg3, John H. Adams4, Peter A. Zimmerman1, Christopher L. King1 Mark Rowland London School of Hygiene and Tropical Medicine, London, United Kingdom 1Case Western Reserve University, Cleveland, OH, United States, 2University of Notre Dame, Notre Dame, IN, United States, 3University Hospitals, Cleveland, OH, United States, 4University of South Florida, Tampa, FL, United States

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4:35 p.m. CHAIR A RIGOROUS ASSAY TO MEASURE SPATIAL Joel G. Breman REPELLENCY FOR AFROTROPICAL MOSQUITO Fogarty International Center, National Institutes of Health, Bethesda, MD, United States CONTROL USING EXPERIMENTAL HUTS AND TENT- TRAPS INTRODUCTORY REMARKS Sarah Moore Joel G. Breman London School of Hygiene and Tropical Medicine, London, United Kingdom Fogarty International Center, National Institutes of Health, Bethesda, MD, United States 5 p.m. DO WE NEED TO LOOK BEYOND ACTS? DO MOSQUITO REPELLENTS AND COILS PROVIDE Nicholas White PROTECTION AGAINST VECTOR-BORNE DISEASE? Mahidol Oxford Research Unit, Mahidol University, Bangkok, Thailand A SUMMARY OF CLINICAL EVALUATIONS AGAINST NOVEL ANTI-MALARIAL DRUGS IN THE PIPELINE MALARIA, DENGUE AND JE Ian Bathurst Nigel Hill Medicines for Malaria Venture, Geneva, Switzerland London School of Hygiene and Tropical Medicine, London, United Kingdom PRIORITIES FOR ANTI-MALARIA DRUG DEVELOPMENT Plenary Session 52 Ramanan Laxminarayan Resources for the Future, Washington, DC, United States Plenary Session II: Fred L. Soper Lecture PANEL DISCUSSION CONCLUDING REMARKS Salon 2 Joel G. Breman Thursday, November 19, 6 p.m. - 6:45 p.m. Fogarty International Center, National Institutes of Health, Bethesda, MD, United States The Fred L. Soper Lecture is an honor bestowed on a distinguished scientist involved in studies related to environmental control and preventive medicine in the tropics. Friday, November 20

CHAIR Registration Robert B. Tesh University of Texas Medical Branch, Galveston, TX, United States Salon Foyer Friday, November 20, 7 a.m. - 5 p.m. INTRODUCTION Peter J. Hotez Cyber Cafe The George Washington University, Washington, DC, United States Marriott Foyer WHEN NATURE TURNS COOK: AN EPIDEMIOLOGICAL Friday, November 20, 7 a.m. - 5 p.m. FEAST David Heymann Speaker Ready Room Health Protection Agency, London, United Kingdom Maryland A Poster Session A Dismantle Friday, November 20, 7 a.m. - 6 p.m. ASTMH Journal Editorial Board Meeting Exhibit Hall B South Thursday, November 19, 7 p.m. - 8 p.m. Wilson C Friday, November 20, 7 a.m. - 8 a.m. Satellite Symposium Clinical Group Past Presidents Meeting

A Glimpse into the Future of Anti-Malarial Drug Room 8212 Development Friday, November 20, 7 a.m. - 8 a.m. Education Committee Meeting Sponsored by Pfi zer Inc. Virginia AB Room 8211 Thursday, November 19, 7:15 p.m. – 9 p.m. Friday, November 20, 7 a.m. - 8 a.m.

Artimisinin based therapies (ACTs) are currently the mainstay of treatment Media Room of acute symptomatic falciparum malaria. As the emergence of drug resistant Plasmodium vivax strains becomes widespread and as malaria programs move Rooms 8228/8229 from control to eradication and elimination phases, there will be a need for Friday, November 20, 7:30 a.m. - 6:30 p.m. antimalarial agents with very different target product profi les. This symposium will address these future needs, the novel target product profi les, current pipeline of compounds in discovery, research and early development and how they fi t in with the desired product profi les, and fi nally how to prioritize their development in the current resource constraint environment.

106 ASTMH 58th Annual Meeting www.astmh.org

Session 52A CHAIR Lawrence Slutsker Enteric and Diarrheal Diseases (EDD), a Priority of the Centers for Disease Control and Prevention, Atlanta, GA, United States Bill & Melinda Gates Foundation Pedro L. Alonso Barcelona Centre for International Health Research, University of Barcelona, Barcelona, Salon 3 Spain Friday, November 20, 7 a.m. - 7:45 a.m. 8 a.m. The Bill & Melinda Gates Foundation will briefl y discuss their investments in HISTORICAL BACKGROUND AND LESSONS LEARNED enteric and diarrheal diseases and the foundation’s long-term goal(s) in this Carlos C. (Kent) Campbell area. A small number of grants will be highlighted and representatives from PATH Malaria Control and Evaluation Partnership in Africa (MACEPA), Seattle, those institutions will be asked to provide a brief overview of their programs. WA, United States A question and answer session will follow. A light breakfast will be served. 8:10 a.m. CHAIR MALERA OVERVIEW AND CONTEXT Thomas Brewer Bill & Melinda Gates Foundation, Seattle, WA, United States Pedro L. Alonso Barcelona Centre for International Health Research, University of Barcelona, Barcelona, INTRODUCTION TO THE EDD PROGRAM Spain Thomas Brewer Bill & Melinda Gates Foundation, Seattle, WA, United States 8:20 a.m. ROTAVIRUS, SHIGELLA, ETEC VACCINES DEFINING THE KNOWLEDGE GAPS - BASIC SCIENCE John Boslego Bob Sinden PATH, Washington, DC, United States Imperial College Science Technology and Medicine, London, United Kingdom TYPHOID, CHOLERA VACCINES 8:30 a.m. John Clemens DEFINING THE KNOWLEDGE GAPS - TOOLS - VACCINES International Vaccines Institute, Seoul, Republic of Korea AND DRUGS GEMS NETWORK Christopher V. Plowe Myron M. Levine University of Maryland School of Medicine, Baltimore, MD, United States University of Maryland School of Medicine, Baltimore, MD, United States MAL-ED NETWORK 8:45 a.m. Mark Miller DEFINING THE KNOWLEDGE GAPS - TOOLS - VECTOR Fogarty International Center, National Institutes of Health, Bethesda, MD, United CONTROL States Frank Collins Michael Gottlieb University of Notre Dame, Notre Dame, IN, United States Foundation for tha National Institutes of Health, Bethesda, MD, United States 8:55 a.m. DEVELOPING AN ANTI-SECRETORY DRUG Richard Chin CROSS-CUTTING THEMES AND INTEGRATION Institute for OneWorld Health, San Francisco, CA, United States Lawrence Slutsker Centers for Disease Control and Prevention, Atlanta, GA, United States Friday, November 20 Symposium 53 9:10 a.m. Malaria Eradication R&D Agenda: Update and Input CROSS-CUTTING THEMES AND INTEGRATION Marcel Tanner Salon 1 Swiss Tropical Institute, Basel, Switzerland Friday, November 20, 8 a.m. - 9:45 a.m. 9:30 a.m. Research and development (R&D) forms a crucial part of the global strategy GUIDED FEEDBACK/DISCUSSION to control, eliminate and ultimately eradicate malaria. The malaria eradication research agenda (malERA) process is engaging the scientifi c community in a Brian Greenwood series of consultations to defi ne the key knowledge gaps and tools needed in order London School of Hygiene and Tropical Medicine, London, United Kingdom to achieve this long-term, ultimate goal. This process is a natural extension of the Pedro Alonso Global Malaria Action Plan that was presented in September 2008. The overall Barcelona Centre for International Health Research, University of Barcelona, Barcelona, aim is to develop a multi-disciplinary global R&D agenda (white paper) that can Spain be actionable by research and public health agencies and sponsors. Consensus building and strengthening collaboration and linkages within the research community are other important components. Over the past year, experts from different technical areas have come together in consultations and have produced a series of documents that will form the consolidated white paper. This symposium will build on this work by offering researchers and implementers an opportunity to review the technical outputs thus far and provide their input. The symposium will begin with an overview of the malERA context and process and be followed by presentations highlighting the key points from the previous consultations. Discussion and feedback will follow the presentations.

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Scientifi c Session 54 9 a.m. 343 Malaria - Biology and Pathogenesis I Salon 2 ABO POLYMORPHISM AND PLASMODIUM FALCIPARUM Friday, November 20, 8 a.m. - 9:45 a.m. MALARIA: ENHANCED PHAGOCYTOSIS OF INFECTED O ERYTHROCYTES CHAIR Kayla T. Wolofsky1, Kodjo Ayi1, W. Conrad Liles1, Christine M. Cserti- Abdullah Bokhari Gazdewich2, Kevin C. Kain1 National Institutes of Health, Rockville, MD, United States 1McLaughlin-Rotman Centre for Global Health, University Health Network, University 2 Mark Wacker of Toronto, Toronto, ON, Canada, Blood Transfusion Laboratory, Toronto General University of Notre Dame, South Bend, IN, United States Hospital, Department of Laboratory Hematology, University of Toronto, Toronto, ON, Canada 8 a.m. 9:15 a.m. 339 344 COMPARATIVE ANALYSIS OF SECRETED PROTEINS IN STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION APICOMPLEXAN PARASITES OF THE BINDING REGION OF PLASMODIUM FALCIPARUM Rays H. Jiang, Daniel E. Neafsey VAR2CSA DBL3X WITH CHONDROITIN SULFATE A The Broad Institute of MIT and Harvard, Cambridge, MA, United States (ACMCIP Abstract) Kavita Singh1, Rossitza K. Gitti2, Apostolos G. Gittis1, Phuc G. Nguyen1, Michael J. Mohan1, D. Channe Gowda1, D. Channe Gowda3, Gregory Tullo1, 8:15 a.m. Hong Zhou1, Rick Fairhurst1, Carole Long1, David N. Garboczi1 1National Institute of Allergy and Infectious Diseases/National Institutes of Health, 340 Rockville, MD, United States, 2ECB Forensic Analytical Branch, Aberdeen, MD, United States, 3Pennsylvania State University College of Medicine, Hershey, PA, United States GENETIC MAPPING IN TWO P. FALCIPARUM CROSSES 9:30 a.m. IDENTIFIES A LOCUS ENCODING THE PLASMODIAL SURFACE ANION CHANNEL 345 Abdullah A. Bokhari, Sanjay A. Desai National Institute of Allergy and Infectious Diseases, National Institutes of Health, IMMEDIATE NEUROPSYCHOLOGICAL AND Rockville, MD, United States BEHAVIORAL BENEFITS OF COMPUTERIZED COGNITIVE REHABILITATION IN UGANDAN PEDIATRIC 8:30 a.m. CEREBRAL MALARIA SURVIVORS 341 Paul Bangirana1, Bruno Giordani2, Chandy C. John3, Connie Page4, Robert O. Opika1, Michael J. Boivin4 1Makerere University, Kampala, Uganda, 2University of Michigan, Ann Arbor, MI, MAPPING THE GENETIC CONTROL OF THE GLOBAL United States, 3University of Minnesota, Minneapolis, MN, United States, 4Michigan METABOLITE PROFILE IN PLASMODIUM FALCIPARUM State University, East Lansing, MI, United States Mark A. Wacker1, Kellen A. Olszewski2, Asako Tan1, Geoffrey H. Siwo1, Joshua D. Rabinowitz3, Maneul Llinas2, Michael T. Ferdig1 Symposium 55 1Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States, 2Department of Molecular Biology and Lewis-Singler Institute for Integrative Genomics, Princeton University, Princeton, NJ, United States, 3Department of Chemistry Launching Careers in Tropical Disease Research: Progress and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, Reports from Burroughs Wellcome Fund/ASTMH and United States Fellows 8:45 a.m. Supported with funding from the Burroughs Wellcome Fund 342 Salon 3 Friday, November 20, 8 a.m. - 9:45 a.m. IMMUNE CONSTRAINTS ON PARASITEMIA AND This session will highlight the work of the Burroughs Wellcome Fund/ GAMETOCYTEMIA IN MALARIA: INSIGHT FROM ASTMH fellows who are focusing their work on global health problems in situ NUMERICAL STUDIES -- doing excellent research on tropical diseases where they occur. Both of these Philip G. McQueen, F. Ellis McKenzie highly competitive fellowship programs focus on training excellent U.S.-based National Institutes of Health, Bethesda, MD, United States researchers who are launching research careers that are expected to involve long-term research presence both abroad and at their home institutions in the United States. There will also be a discussion of career issues faced by those who take on working in two countries (home and abroad).

CHAIR Jean Kramarik Burroughs Wellcome Fund, Research Triangle Park, NC, United States Victoria P. McGovern Burroughs Wellcome Fund, Research Triangle Park, United States

108 ASTMH 58th Annual Meeting www.astmh.org

8 a.m. 8 a.m. DIAGNOSING TB AMIDST CONVERGING DRUG- PEDIATRIC INVASIVE NON-TYPHOIDAL SALMONELLA RESISTANT TB AND HIV EPIDEMICS IN RURAL SOUTH INFECTIONS IN SUB-SAHARAN AFRICA - A MAJOR AFRICA KILLER Scott Heysell Myron M. Levine Yale University School of Medicine, New Haven, CT, United States University of Maryland School of Medicine, Baltimore, MD, United States 8:25 a.m. 8:25 a.m. THE INTERACTION BETWEEN HIV AND MALARIA: ENDEMIC INVASIVE NON-TYPHOIDAL SALMONELLA WHAT WE STILL DON’T KNOW DISEASE IN URBAN AND RURAL SETTINGS IN KENYA Matthew B. Laurens DETECTED BY ACTIVE COMMUNITY SURVEILLANCE University of Maryland School of Medicine, Baltimore, MD, United States Robert F. Breiman Centers for Disease Control and Prevention - KEMRI, Nairobi, Kenya 8:50 a.m. FROM TYPHOID TO RICKETTSIAE: EXPLORING 8:50 a.m. ETIOLOGIES OF ACUTE FEBRILE ILLNESS IN SOUTH GENOMICS PROVIDES INSIGHTS ON INVASIVE NTS IN ASIA SUB-SAHARAN AFRICA Megan E. Reller Gordon Dougan Johns Hopkins Medical Institutions, Baltimore, MD, United States The Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom 9:15 a.m. 9:15 a.m. QUESTIONS AND ANSWERS VACCINES TO PREVENT INVASIVE NON-TYPHOIDAL Terrie Taylor SALMONELLA INFECTIONS IN INFANTS AND YOUNG Michigan State University, East Lansing, MI, United States CHILDREN Allan Saul Symposium 56 Novartis Vaccine Institute for Global Health S.r.l., Siena, Italy

Invasive Non-Typhoidal Salmonella Disease in Africa Symposium 57

Delaware A Pre-Referral Rectal Artesunate in Rural African Friday, November 20, 8 a.m. - 9:45 a.m. Communities - Experience in Use During the past decade, population-based systematic blood culture Delaware B surveillance has been ongoing in several centers in sub-Saharan Africa to detect invasive bacterial pathogens among infants and young children seen Friday, November 20, 8 a.m. - 9:45 a.m. in health care facilities. Whereas such surveillance was mainly intended to quantify the burden of invasive Haemophilus infl uenzae type b and Streptococcus A single dose of rectal artesunate cannot cure severe malaria, but it can pneumoniae infections, a high frequency of isolation of non-typhoidal rapidly reduce parasite count and gives enough pause to disease progression in Salmonella (NTS) was revealed. In Kenya, Malawi, Gambia and Mali, the patients heading towards death or permanent brain damage for them to reach incidence of invasive NTS disease rivaled that of pneumococcal disease and proper treatment in time. The intervention, however, requires information on how it can be made available in remote communities to achieve benefi t.

case fatality rates of 8-25% were recorded. Serovars Salmonella Typhimurium Friday, November 20 and Enteritidis account for 80-95% of isolates and antibiotic resistance is What are the practical challenges in making the drug available in remote common. Where comparable systematic population-based surveillance of malaria endemic communities? Can mothers, community healthworkers or febrile pediatric patients has been carried out in Asia, S. Typhi was commonly traditional healers treat, refer and follow up patients? Will patients or their isolated among toddlers and young children in some sites, but NTS was parents and guardians feel that hospitalization can be deferred after a patient conspicuously absent. What accounts for the high burden of pediatric invasive has received a suppository? What is the cost-effectiveness of this intervention? NTS disease in Africa? Are unusual NTS circulating? Are there genetic or The symposium will provide answers to these questions from experience from environmental host factors specifi c to children in Africa? What measures, several countries in Africa. including vaccines, can control this public health problem in Africa? This symposium will provide an overview of invasive NTS disease in Africa, CHAIR including epidemiology, clinical features, serovar distribution, pathogenesis Melba Gomes and host factors. Results of active surveillance in both urban and rural sites in World Health Organization, Geneva, Switzerland Kenya will be presented. Molecular epidemiologic and genomic investigations Malcolm Molyneux of NTS isolates from East and South Africa will demonstrate unique features Liverpool School of Tropical Medicine, Liverpool, United Kingdom of some African isolates (including insights from the complete genome sequence of an invasive S. Typhimurium isolate). 8 a.m.

CHAIR WHAT IS THE EFFECTIVENESS AND SAFETY OF NEAR- HOME MANAGEMENT OF SEVERE MALARIA IN THE Myron M. Levine University of Maryland School of Medicine, Baltimore, MD, United States REAL-LIFE SETTING? Eric D. Mintz Amabelia Rodrigues Centers for Disease Control and Prevention, Atlanta, GA, United States Bandim Health Project, Bissau, Guinea-Bissau

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8:30 a.m. 8:50 a.m. HOW CAN ARTESUNATE SUPPOSITORIES BE NEW TOOLS DEVELOPMENT AND CHALLENGES DISTRIBUTED TO ACHIEVE MAXIMUM BENEFIT? TO THEIR UPTAKE IN THE FIELD: MAPPING A WAY EXPERIENCE FROM FIVE COUNTRIES IN SUB-SAHARAN FORWARD AFRICA Giorgio Roscigno Joseph Rujumba Foundation for Innovative New Diagnostics, Geneva, Switzerland Makerere University, Kampala, Ghana 9:15 a.m. 8:50 a.m. SETTING PRIORITIES FOR PREVENTION AND CONTROL DO PATIENTS OR THEIR PARENTS AND GUARDIANS OF DRUG RESISTANT TUBERCULOSIS FEEL THAT HOSPITALIZATION CAN BE DEFERRED Michael E. Kimerling AFTER A PATIENT HAS RECEIVED A SUPPOSITORY? Bill & Melinda Gates Foundation, Seattle, WA, United States Rita Baiden InDepth, Accra, Ghana Symposium 59

9:10 a.m. Yellow Fever Risk Mapping – Old Disease, New WHAT IS THE COST-EFFECTIVENESS OF RECTAL Approaches ARTESUNATE? Borislava Mihaylova Virginia C University of Oxford, Oxford, United Kingdom Friday, November 20, 8 a.m. - 9:45 a.m.

Recent events, such as continued reports of rare but severe and fatal adverse events associated with yellow fever (YF) vaccine (YF vaccine-associated viscerotropic disease), and the reemergence of urban transmission of YF Symposium 58 disease in Paraguay in early 2008, have highlighted the importance of fi nding new approaches for mapping countries at risk for YF, to aid in guiding YF Challenges to Tuberculosis Control in the 21st Century: vaccine recommendations for local populations and for international travelers. Urgency and Innovation To accomplish this goal, a systematic review of every country with either a previous or current assessment of being at risk for yellow fever is being Virginia AB conducted by an international working group (WG) of YF experts, including Friday, November 20, 8 a.m. - 9:45 a.m. those from WHO and CDC. This symposium will describe the use of historical approaches to mapping, as well as sophisticated computerized mapping The WHO global report of 2009 shows more cases of tuberculosis than in any programs, and the inclusion of human, animal and ecological data and fi ndings previous year (9.3 million) and a rising rate of MDR-TB, with over one-half from recent fi eld investigations will be presented. million estimated cases per year. Additionally, nearly 50% of tuberculosis cases are not detected or reported. However, 2009 is also a year in which there is CHAIR global momentum to address the epidemic and an increasingly aligned global Nina Marano architecture to face it. This symposium will address some of the bottlenecks to Centers for Disease Control and Prevention, Atlanta, GA, United States TB control in the 21st century and the specifi c challenges posed by HIV co- Gilles Poumerol infection, drug resistance and the use of century-old technologies for diagnosis. World Health Organization, Geneva, Switzerland It will also highlight global efforts and strategies for turning a sense of urgency into actions for innovation. 8 a.m. CHAIR CURRENT ISSUES REGARDING RISK OF YELLOW FEVER Michael E. Kimerling Thomas P. Monath Bill & Melinda Gates Foundation, Seattle, WA, United States Kleiner Perkins Caufi eld & Byers, Harvard, MA, United States Peter Godfrey-Faussett 8:25 a.m. London School of Hygiene and Tropical Medicine, London, United Kingdom HISTORICAL MAPPING FOR YELLOW FEVER 8 a.m. Mark Gershman CURRENT GLOBAL ESTIMATES AND THE CHALLENGES Centers for Disease Control and Prevention, Atlanta, GA, United States TO FINANCE THE GLOBAL PLAN 8:50 a.m. Katherine Floyd World Health Organization, Geneva, Switzerland FIELD ASSESSMENT OF YELLOW FEVER ACTIVITY IN SOUTH AMERICA 8:25 a.m. Erin Staples CONSORTIUM TO RESPOND EFFECTIVELY TO THE Centers for Disease Control and Prevention, Fort Collins, CO, United States AIDS/TB EPIDEMIC: APPLYING EXISTING TOOLS AND 9:15 a.m. COMMUNITY ENGAGEMENT TO CHANGE POLICY Peter Godfrey-Faussett MODELLING APPROACH TO MAPPING YELLOW FEVER London School of Hygiene and Tropical Medicine, London, United Kingdom RISK David Rogers Oxford University, Oxford, United Kingdom

110 ASTMH 58th Annual Meeting www.astmh.org

Scientifi c Session 60 9:15 a.m. 349 American Committee of Molecular, Cellular and Immunoparasitology (ACMCIP): Immunoparasitology I SUBVERSION OF INNATE IMMUNE SIGNALS BY Supported with funding from the Burroughs Wellcome Fund SCHISTOSOMA MANSONI PERMITS WORM DEVELOPMENT Washington 1 Diana K. Riner, Sean K. Maynard, Stephen J. Davies Friday, November 20, 8 a.m. - 9:45 a.m. Uniformed Services University of the Health Sciences, Bethesda, MD, United States

CHAIR 9:30 a.m. Lisa Ganley-Leal Boston University School of Medicine, Boston, MA, United States 350 Qyana Griffi th Boston University School of Medicine, Boston, MA, United States REGULATION OF INNATE IMMUNITY TO LEISHMANIA INFECTION BY TYPE I IFN SIGNALING 8 a.m. Lijun Xin, Diego A. Vargas-Inchaustegui, Jiaren Sun, Lynn Soong KEYNOTE ADDRESS: IMMUNOPARASITOLOGY The University of Texas Medical Branch, Galveston, TX, United States 8:15 a.m.

1149 Symposium 61

MHC CLASS II-DEPENDENT BASOPHIL-CD4+ T CELL Panel Discussion on the Involvement of Human Subjects in INTERACTIONS PROMOTE TH2 CELL-DEPENDENT Vector Biology Research IMMUNITY AND INFLAMMATION Washington 2 Jacqueline G. Perrigoue1, Steven A. Saenz1, Mark Siracusa1, Eric J. Allenspach1, Betsy C. Taylor1, Paul R. Giacomin1, Meera G. Nair1, Yurong Friday, November 20, 8 a.m. - 9:45 a.m. Du1, Colby Zaph2, Michael R. Comeau3, Terri M. Laufer1, David Artis1 Research on the biology and ecology of vectors of human pathogens sometimes 1 2 University of Pennsylvania, Philadelphia, PA, United States, University of British involves interactions with human subjects. However, there is disagreement 2 Columbia, Vancouver, BC, Canada, Amgen Inc., Seattle, WA, United States as to when these interactions should be classifi ed as “human subjects research” and its oversight implications, and when they should be classifi ed 8:30 a.m. as “biohazard” or “occupational hazard”. This panel discussion is a fi rst step to provide some clarity on this topic and to the development of guidelines that 346 will help investigators and others involved in vector research with this topic.

ANTIGEN SPECIFICITY OF CD23 (FCEPSILONRII)- CHAIR BOUND IGE MODULATES B CELL RESPONSES: Adriana Costero IMPLICATIONS FOR IMMUNITY TO SCHISTOSOMIASIS National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States Qyana Kelly Griffi th1, YanMei Liang1, Taslima Shaikh2, Helmut Haas3, Daniel Onguru4, Pauline Mwinzi4, Lisa Ganley-Leal1 8 a.m. 1Boston University School of Medicine, Boston, MA, United States, 2Boston University, THE INVESTIGATOR PERSPECTIVE: VALUE AND NEED Friday, November 20 Boston, MA, United States, 3Research Center Borstel, Borstel, Germany, 4Kenya Medical FOR THE INVOLVEMENT OF HUMAN SUBJECTS IN Research Institute, Kisumu, Kenya VECTOR RESEARCH 8:45 a.m. Dawn M. Wesson Tulane University, New Orleans, LA, United States 347 8:25 a.m. IN UTERO EXPOSURE TO MATERNAL SCHISTOSOMIASIS THE SPONSOR PERSPECTIVE: SAFETY AND DATA MODULATES ACUTE AND MEMORY CELLULAR AND INTEGRITY IN CLINICAL RESEARCH HUMORAL IMMUNE RESPONSES OF OFFSPRING Mirjana Nesin National Institutes of Health/National Institute of Allergy and Infectious Diseases, Allison C. Brown, William J. Moss Bethesda, MD, United States The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States 8:50 a.m. 9 a.m. THE ETHICIST PERSPECTIVE: ENSURING THE HIGHEST 348 STANDARDS FOR CLINICAL RESEARCH James Lavery SCHISTOSOMES TARGET HUMAN CD23-MEDIATED University of Toronto, Toronto, ON, Canada IMMUNITY IN IMMUNO-EVASIVE TACTICS Qyana Griffi th1, YanMei Liang1, Ashley Cruz1, Helmut Haas2, Lisa Ganley- Leal1 1Boston University School of Medicine, Boston, MA, United States, 2Research Centre Borstel, Borstel, Germany

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9:15 a.m. 8:45 a.m. BALANCING THE TENSIONS BETWEEN RESEARCH AND 354 HUMAN SAFETY IN VECTOR BIOLOGY RESEARCH Adriana Costero WHAT IS ENHANCED SURVEILLANCE?: DESCRIPTION National Institutes of Health/National Institute of Allergy and Infectious Diseases, OF AN ENHANCE DENGUE SURVEILLANCE SYSTEM Bethesda, MD, United States MODEL - THE PATILLAS ENHANCED DENGUE Scientifi c Session 62 SURVEILLANCE SYSTEM (PEDSS), PATILLAS PUERTO RICO Flavivirus - Dengue II D. Fermín Argüello1, Gladys González-Zeno1, E. Brian Irizarry-Pérez1, Mary Ramos2, Luz Quiñones1, Aidsa Rivera1, Christine Luxemburger3, Viviane Washington 3 Jusot3, Jorge Muñoz1, Elizabeth Hunsperger1, Wellington Sun4, Kay M. Tomashek1 Friday, November 20, 8 a.m. - 9:45 a.m. 1Centers for Disease Control and Prevention, San Juan, PR, United States, 2Department of Pediatrics, University of New Mexico, Albuquerque, NM, United States, 3Sanofi CHAIR Pasteur, Lyon, France, 4United States Food and Drug Administration, Rockville, MD, David F. Arguello United States Centers for Disease Control and Prevention, San Juan, PR, United States Rebeca Rico-Hesse 9 a.m. Southwest Foundation for Biomedical Research, San Antonio, TX, United States 355 8 a.m. TUMOR NECROSIS FACTOR (TNF) AND LYMPHOTOXIN- 351 ALPHA (LTA) GENE ASSOCIATIONS WITH DENGUE VIRUS INFECTION IN ETHNIC THAIS VIRAL DETERMINANTS OF DENGUE VIRUS FITNESS Henry A. Stephens1, Sasijit Vejbaesya2, Panpimon Luangtrakool2, Komon AND VIRULENCE REVEALED IN THE EVOLUTION OF Luangtrakool2, Siripen Kalayanarooj3, David W. Vaughn4, Timothy P. Endy4, DENGUE VIRUS SEROTYPE 2 IN NICARAGUA Mammen P. Mammen4, Sharone Green5, Daniel H. Libraty5, Francis A. 5 5 Molly OhAinle1, Matthew R. Henn2, Aubree Gordon1, Tangni Gomez3, Ennis , Alan L. Rothman 1 2 Yolanda Tellez3, Saira Saborío3, Bruce Birren2, Angel Balmaseda3, Eva Harris1 University College London, London, United Kingdom, Department of Transfusion 1Division of Infectious Diseases and Vaccinology, School of Public Health, University of Medicine, Siriraj Hospital and Medical School, Mahidol University, Bangkok, Thailand, 3 4 California, Berkeley, Berkeley, CA, United States, 2Broad Institute, Cambridge, MA, Queen Sirikit National Institute of Child Health, Bangkok, Thailand, Department United States, 3Departamento de Virología, Centro Nacional de Diagnóstico y Referencia, of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand, 5 Ministerio de Salud, Managua, Nicaragua Center for Infectious Diseases and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, United States 8:15 a.m. 9:15 a.m. 352 356 ASSESSING THE ROLE OF HUMAN MOVEMENT IN THE ROLE OF B CELL MEMORY IMMUNITY IN SECONDARY TRANSMISSION DYNAMICS OF DENGUE VIRUS IN DENGUE VIRUS INFECTIONS IN MICE IQUITOS, PERU Simona Zompi, Katherine Williams, P. Robert Beatty, Eva Harris Steven T. Stoddard1, Amy C. Morrison1, Brett M. Forshey1, Valerie Paz Division of Infectious Diseases and Vaccinology, School of Public Health, University of Soldan2, Helvio Astete1, John P. Elder3, Gonzalo Vasquez-Prokopec4, Uriel California, Berkeley, Berkeley, CA, United States Kitron4, Tadeusz J. Kochel5, Thomas W. Scott1 1 2 University Of California, Davis, Davis, CA, United States, Tulane University, New 9:30 a.m. Orleans, LA, United States, 3San Diego State University, San Diego, CA, United States, 4Emory University, Atlanta, GA, United States, 5Naval Medical Research Center Detachment, Lima, Peru 357

8:30 a.m. HUMANIZED MICE SHOW DIFFERENCES IN DISEASE PRESENTATION ACCORDING TO INFECTING DENGUE 353 VIRUS GENOTYPE Javier Mota, Rebeca Rico-Hesse AGE SHIFTS OF DHF IN BRAZIL: INSIGHT FROM A Southwest Foundation for Biomedical Research, San Antonio, TX, United States SEROLOGICAL SURVEY IN RECIFE Isabel Rodriguez-Barraquer1, Ernesto Marques2, Derek A. Cummings1 1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 2Johns Hopkins School of Medicine, Baltimore, MD, United States

112 ASTMH 58th Annual Meeting www.astmh.org

Symposium 63 Scientifi c Session 64

Update on Chagas Disease in the United States: Blood Mosquitoes - Biochemistry, Molecular Biology and Bank Screening and Diagnostic Options Molecular Genetics I Washington 4 Washington 5 Friday, November 20, 8 a.m. - 9:45 a.m. Friday, November 20, 8 a.m. - 9:45 a.m.

Most blood banks in the United States have screened donations for CHAIR Trypanosoma cruzi since January 2007, and to date, 782 previously Luke Alphey undiagnosed infections have been detected. Because of blood screening and Oxitec Limited, Abingdon, United Kingdom immigration from endemic regions, U.S. clinicians are increasingly called upon to evaluate patients with suspected Chagas disease, but few have experience Megan R. Wise de Valdez Colorado State University, Fort Collins, CO, United States in the diagnostic complexities of the disease. In the acute phase of Chagas disease, parasitemia is often detectable by microscopy, culture and PCR. By 8 a.m. contrast, diagnosis in the chronic phase relies on application of at least two serological tests based on different antigens and/or principles. Discordances may be diffi cult to resolve because there is no true gold standard assay for 358 chronic T. cruzi infection. This symposium will review clinical and biological aspects of the disease, decisions regarding the best diagnostic tests in the acute A LARGE SCALE LABORATORY INVESTIGATION OF THE and chronic phases, discuss the performance characteristics and limitations of RELEASE OF INSECTS CARRYING A DOMINANT LETHAL available assays, give an overview of blood bank screening and explore future GENE (RIDL®) AS AN EFFECTIVE CONTROL STRATEGY directions in Chagas disease diagnosis. FOR AEDES AEGYPTI MOSQUITOES

1 2 2 2 CHAIR Megan R. Wise de Valdez , Derric Nimmo , Hong-Fei Gong , Luke Alphey , William C. Black, IV1 Caryn Bern 1Colorado State University, Fort Collins, CO, United States, 2Oxitec Ltd., Abingdon, Centers for Disease Control and Prevention, Atlanta, GA, United States United Kingdom Susan Montgomery Centers for Disease Control and Prevention, Atlanta, GA, United States 8:15 a.m. 8 a.m. 359 EVALUATION OF PATIENTS WITH SUSPECTED CHAGAS GENETIC CONTROL OF AEDES MOSQUITOES TO DISEASE AND DECISIONS REGARDING TESTING PREVENT DENGUE AND CHIKUNGUNYA Caryn Bern Centers for Disease Control and Prevention, Atlanta, GA, United States Luke Alphey Oxitec Limited, Oxford, United Kingdom 8:25 a.m. 8:30 a.m. ASSAYS FOR THE DIAGNOSIS OF CHRONIC TRYPANOSOMA CRUZI INFECTION IN THE UNITED 360 STATES Charles W. Todd THE EFFECT OF GENE DRIVE ON CONTAINMENT OF

Centers for Disease Control and Prevention, Atlanta, GA, United States TRANSGENIC MOSQUITOES Friday, November 20 John M. Marshall 8:50 a.m. University of California at Los Angeles, Los Angeles, CA, United States SCREENING OF THE UNITED STATES BLOOD SUPPLY: ASSAYS IN CURRENT USE, FUTURE PROSPECTS AND 8:45 a.m. THE RESULTS OF SCREENING SINCE 2007 361 David Leiby American Red Cross, Rockville, MD, United States GENE EXPRESSION PROFILE ANALYSIS OF 9:15 a.m. ANOPHELES GAMBIAE AGING AND BLOOD FEEDING: IDENTIFICATION OF CANDIDATE GENES FOR AGE NEW DIAGNOSTIC TESTS AND PROSPECTS FOR GRADING FUTURE IMPLEMENTATION Mei-Hui Wang1, Osvaldo Marinotti2, Anthony A. James2, Edward Walker3, Rick L. Tarleton Guiyun Yan1 University of Georgia, Athens, GA, United States 1Public Health, University of California, Irvine, Irvine, CA, United States, 2Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, United States, 3Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, United States

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9 a.m. 8:15 a.m.

362 366

POLYMORPHISMS IN ANOPHELES GAMBIAE IMMUNE PROPHYLACTIC EFFECT OF TRIMETHOPRIM- GENES ARE ASSOCIATED TO MALARIA RESISTANCE SULFAMETHOXAZOLE ON MALARIA IN HIV-INFECTED Caroline A. Harris1, Isabelle Morlais2, François Rousset3, Luc Abate1, Didier CHILDREN LIVING IN KAMPALA, UGANDA Fontenille1, Anna Cohuet4 Anne F. Gasasira1, Moses Kamya2, Neil Vora3, Jane Achan2, Fredrick 1Institut de recherche pour le developpement, Montpellier, France, 2OCEAC, Youndé, Katera2, Edwin Charlebois3, Theodore Ruel3, Diane Havlir3, Philip Rosenthal3, Cameroon, 3University of Montpellier, Montpellier, France, 4IRSS, Bobo Dioulasso, Grant Dorsey3 Burkina Faso 1Makerere University/University of California Berkeley, Berkeley, CA, United States, 2Makerere University, Kampala, Uganda, 3University of California, San Francisco, CA, 9:15 a.m. United States 363 8:30 a.m.

DUPLICATION AND CONCERTED EVOLUTION OF 367 VITELLOGENIN GENES IN MOSQUITOES Song Chen, Jason L. Rasgon THE EFFECT OF UNTREATED HIV INFECTION Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United ON MALARIA: DOWN-REGULATING INNATE States INFLAMMATORY RESPONSES Lena Serghides1, Constance A. Finney1, Prameet Seth2, Colin Kovacs3, Mona 9:30 a.m. Loutfy3, Rupert Kaul2, Kevin C. Kain1 1McLaughlin-Rotman Centre for Global Health, UHN and University of Toronto, 364 Toronto, ON, Canada, 2Institute of Medical Science, University of Toronto, Toronto, ON, Canada, 3Canadian Immunodefi ciency Research Collaborative, Toronto, ON, Canada RESPONSE OF MOSQUITO PROTEIN INTERACTION NETWORK TO THE DENGUE INFECTION 8:45 a.m. Zhiyong Xi, Xiang Guo, Yao Xu, Guowu Bian, Andrew David Pike, Yan Xie 368 Michigan State University, East Lansing, MI, United States Scientifi c Session 65 FETAL IMMUNE PRIMING TO PARASITIC ANTIGENS, IMMUNE ACTIVATION AND SUSCEPTIBILITY TO IN VITRO HIV INFECTION HIV in the Tropics Kevin Steiner1, Latoya Myrie1, Indu Malhotra1, Peter Mungai1, Eric Wilson AB Muchiri2, Arlene Dent1, Christopher King1 1Case Western Reserve University, Cleveland, OH, United States, 2Division of Vector Friday, November 20, 8 a.m. - 9:45 a.m. Borne Diseases, Nairobi, Kenya CHAIR 9 a.m. Davidson H. Hamer Boston University School of Public Health, Boston, MA, United States 369 Jean B. Nachega Johns Hopkins University, Baltimore, MD, United States SPECIES-SPECIFIC EFFECTS OF DEWORMING AMONG 8 a.m. HIV AND HELMINTH CO-INFECTED INDIVIDUALS Bradley R. Herrin, Grace John-Stewart, Judd L. Walson 365 University of Washington, Seattle, WA, United States 9:15 a.m. ETIOLOGY OF FEBRILE ILLNESS AMONG HOSPITALIZED HIV-INFECTED AND HIV-UNINFECTED 370 ADULTS AND ADOLESCENTS IN NORTHERN TANZANIA John A. Crump1, Habib O. Ramadhani2, Anne B. Morrissey1, Venance P. REASONS FOR SWITCHING TO SECONDLINE Maro2, Wilbrod Saganda3, Mtumwa S. Mwako3, Andrea V. Shaw1, John A. ANTIRETROVIRAL THERAPY AMONG PATIENTS 1 4 Bartlett , Hugh Reyburn ATTENDING KABALE HOSPITAL/JCRC KABALE HIV 1Duke University Medical Center, Durham, NC, United States, 2Kilimanjaro Christian Medical Centre, Moshi, United Republic of Tanzania, 3Mawenzi Regional Hospital, CLINIC Moshi, United Republic of Tanzania, 4London School of Hygiene and Tropical Medicine, Peterson S. Kyebambe London, United Kingdom Kabale Regional Hospital, Kabale, Uganda

114 ASTMH 58th Annual Meeting www.astmh.org

9:30 a.m. 11:10 a.m. QUESTION AND ANSWER PERIOD 371

PREVALENCE AND CORRELATES OF HELMINTH Symposium 68 INFECTION IN HIV SERO-POSITIVE KENYAN ADULTS Academic Platforms for the Integration of Tropical Barclay T. Stewart1, Laura Sangare2, Loice Mbogo3, Grace John-Stewart2, Judd L. Walson2 Medicine Research and the Promotion of Human Rights 1Medical University of South Carolina, Beaufort, SC, United States, 2University of Washington, Seattle, WA, United States, 3Kenya Medical Research Institute - University Salon 3 of Washington Collaboration, Kilifi , Kenya Friday, November 20, 10:15 a.m. - Noon

Despite their common goal of improved global health, there is often a Exhibit Hall Open signifi cant divide in the fi eld of tropical medicine between academicians, who pursue knowledge through research and education, and human rights workers, Exhibit Hall A who generally strive to provide more direct services through humanitarian Friday, November 20, 9:30 a.m. - 10:30 a.m. organizations. This divide often poses an impediment to the maximum success of both groups and the populations they serve. Academicians conducting fi eld Coffee Break studies could benefi t from partnerships with people and organizations with direct contact in the endemic areas of a health problem of interest, helping Exhibit Hall A to focus their research and facilitate implementation. In turn, humanitarian Friday, November 20, 9:45 a.m. - 10:15 a.m. organizations could benefi t from a more direct stream of data and information Supported with funding from SCYNEXIS, Inc. to implement best practices in the fi eld. Although there are frequently individuals active in both academia and humanitarian aid, few programs Poster Session B Set-Up attempt to formally integrate science and human rights promotion. This symposium will present a few examples of programs that specifi cally seek to Exhibit Hall B South incorporate these two important components of the health sciences. Friday, November 20, 9:45 a.m. - 10:15 a.m. CHAIR Poster Session B Viewing Daniel G. Bausch Exhibit Hall B South Tulane School of Public Health and Tropical Medicine, New Orleans, LA, United States Friday, November 20, 10:15 a.m. - Noon Frederique A. Jacquerioz Tulane School of Public Health and Tropical Medicine, New Orleans, LA, United States Symposium 67 10:15 a.m. UNIVERSITY OF CALIFORNIA, BERKELEY AND THE Global Health Cornerstone Symposium II SUSTAINABLE SCIENCES INSTITUTE Salon 2 Eva Harris University of California at Berkeley, Berkeley, CA, United States Friday, November 20, 10:15 a.m. - Noon 10:40 a.m. This year marks the fi rst ASTMH conference that features a formal series of symposia centered around globalization’s impact on health, health disparities TULANE UNIVERSITY AND DOCTORS FOR GLOBAL

and global health partnerships. This session features Dr. Harold Varmus, HEALTH Friday, November 20 who has spoken extensively on the need for science to inform public policy Daniel Bausch and on the U.S. commitment to global health. Dr. Varmus co-chairs The Tulane University, New Orleans, LA, United States Institute of Medicine’s Committee on the U.S. Commitment to Global Health, which recently released the report, “The U.S. Commitment to Global Health: 11:05 a.m. Recommendations for the Public and Private Sectors.” A question and answer period is anticipated following the presenter’s remarks. LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE AND INNOVATION FOR HEALTH AND CHAIR DEVELOPMENT Michele Barry Carlton A. Evans Stanford University, Stanford, CA, United States London School of Hygiene and Tropical Medicine, London, United Kingdom Thomas E. Wellems ASTMH President, Rockville, MD, United States 11:30 a.m. HARVARD UNIVERSITY AND PARTNERS IN HEALTH 10:15 a.m. Joia Mukherjee INTRODUCTION Harvard University and Partners in Health, Boston, MA, United States Michele Barry Stanford University, Stanford, CA, United States 10:30 a.m. Harold Varmus Memorial Sloan-Kettering Cancer Center, New York, NY, United States

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Symposium 70 Symposium 70A

Brain Disorders in the Developing World Improving the Health of Travelers and New Immigrants and Refugees: Evidence-Based Approaches Delaware B Friday, November 20, 10:15 a.m. - Noon Virginia AB Friday, November 20, 10:15 a.m. - Noon Non-communicable diseases and disorders are rapidly becoming the predominant cause of poor health in all low-to-middle income regions As global travel and migration increase, more efforts are needed to reduce except sub-Saharan Africa (where they are second only to HIV/AIDS). The the spread of infectious diseases and to prepare travelers for health risks. World Health Organization estimates the burden of neurologic diseases – as This symposium will address current approaches to assessing and reducing measured in disability-adjusted life-years – is 30% greater in low-income health risks to travelers and improving the health of migrants. Specifi c countries than in high-income countries. This symposium will showcase topics will include a review of TravEpiNet, a surveillance network to research in four regions of the world funded by the National Institutes of identify characteristics of traveling populations, description of ways in which Health Fogarty International Center’s “Brain Disorders in the Developing information from travelers can be used to assess emerging infectious diseases World” program: 1) retroviral infections of the nervous system (Peru); 2) and develop methods to reduce health risks to travelers and methods of pathogenesis of cognitive and neurologic defi cits in central nervous system reducing illness in immigrant and refugee populations. malaria (Uganda) 3) food toxins and neurodegeneration in sub-Saharan Africa; and 4) childhood diarrhea, nutrition and gene-environment interactions CHAIR in cognitive function (Brazil). Elizabeth D. Barnett CHAIR Boston Medical Center, Boston, MA, United States Yanni Emad Joseph R. Zunt Centers for Disease Control and Prevention, Atlanta, GA, United States University of Washington, Seattle, WA, United States Desire Tshala-Katumbay 10:15 a.m. Oregon Health Sciences University, Portland, OR, United States IMPROVING THE HEALTH OF TRAVELERS: TRAVEPINET 10:15 a.m. Edward T. Ryan RETROVIRAL INFECTIONS OF THE NERVOUS SYSTEM Massachusetts General Hospital, Boston, MA, United States IN PERU 10:40 a.m. Joseph R. Zunt University of Washington, Seattle, WA, United States IMPROVING THE HEALTH OF TRAVELERS: ASSESSING HEALTH RISKS AND BEHAVIOURS BEFORE, DURING 10:40 a.m. AND AFTER TRAVEL PATHOGENESIS OF COGNITIVE AND NEUROLOGIC Davidson H. Hamer DEFICITS IN CENTRAL NERVOUS SYSTEM MALARIA Boston University, Boston, MA, United States Chandy C. John 11:05 a.m. University of Minnesota, Minneapolis, MN, United States IMPROVING THE HEALTH OF TRAVELERS: USING 11:05 a.m. SEROSURVEYS TO ASSESS TRAVEL RELATED HEALTH FOOD TOXINS AND NEURODEGENERATION IN SUB- RISKS SAHARAN AFRICA Elizabeth D. Barnett Boston Medical Center, Boston, MA, United States Desire Tshala-Katumbay Oregon Health and Science University, Portland, OR, United States 11:30 a.m. 11:30 a.m. IMPROVING THE HEALTH OF IMMIGRANTS AND CHILDHOOD DIARRHEA, NUTRITION AND GENE- REFUGEES: EVIDENCE-BASED APPROACHES ENVIRONMENT INTERACTIONS IN COGNITIVE William M. Stauffer FUNCTION University of Minnesota, Minneapolis, MN, United States Richard Guerrant University of Virginia, Charlottesville, VA, United States Symposium 71

30 Years of Building a Research Platform: The KEMRI/ Centers for Disease Control and Prevention Collaboration Virginia C Friday, November 20, 10:15 a.m. - Noon

This symposium will trace the roots of the present KEMRI/CDC Collaboration in Kisumu, Kenya from 1979, the early malaria research days, to the present, where the KEMRI/CDC Collaboration has grown into a major research platform investigating multiple infectious diseases

116 ASTMH 58th Annual Meeting www.astmh.org

CHAIR 10:30 a.m. Kayla Laserson KEMRI/Centers for Disease Control and Prevention, Kisumu, Kenya 380 John Vulule KEMRI Center for Global Health Research, Kisumu, Kenya BASOPHILS PLAY A POSSIBLE IMMUNO-REGULATORY Larry Slutsker ROLE DURING S. MANSONI INFECTION IN MICE Centers for Disease Control and Prevention, Atlanta, GA, United States William K. Anyan1, Takashi Kumagai1, Kazushige Obata1, Reiko Shimogawara1, Bethel Kwansa-Bentum1, Kwabena M. Bosompem2, Hajime 10:15 a.m. Karasuyama1, Nobuo Ohta1 1Tokyo Medical and Dental University, Tokyo, Japan, 2Noguchi Memorial Institute for DEMOGRAPHIC SURVEILLANCE: PAST, PRESENT AND Medical Research, Accra, Ghana FUTURE (ACMCIP Abstract) Allen Hightower Centers for Disease Control and Prevention-Kenya, Kisumu, Kenya 10:45 a.m.

10:40 a.m. 381 KEMRI/CENTERS FOR DISEASE CONTROL AND PREVENTION MALARIA RESEARCH: LOCAL, NATIONAL INCREASES IN SCHISTOSOME-SPECIFIC IGE AND AND GLOBAL IMPACT CD19+/CD23+ B CELLS IN A COHORT OF KENYAN CHILDREN UNDERGOING REPEATED TREATMENT AND Mary J. Hamel KEMRI/Centers for Disease Control and Prevention, Kisumu, Kenya REINFECTION WITH SCHISTOSOMA MANSONI Carla L. Black1, Erick M. Muok2, Jennifer M. Carter1, Pauline N. Mwinzi2, 11:05 a.m. Diana M. Karanja2, W. Evan Secor3, Daniel G. Colley1 1University of Georgia, Athens, GA, United States, 2Kenya Medical Research Institute, THE CUTTING EDGE: RESEARCH AND CONTROL AT Kisumu, Kenya, 3Centers for Disease Control and Prevention, Atlanta, GA, United States THE EPICENTER OF THE KENYA HIV/AIDS EPIDEMIC (ACMCIP Abstract) Kevin DeCock Centers for Disease Control and Prevention-Kenya, Nairobi, Kenya 11 a.m. 11:30 a.m. 382 THE RISE OF CDC’S GLOBAL DISEASE DETECTION ACTIVITIES IN KENYA FACTORS ASSOCIATED TO TOTAL AND SPECIFIC IGE LEVELS IN RESIDENTS OF AN ENDEMIC AREA FOR Daniel Feikin KEMRI/Centers for Disease Control and Prevention, Kisumu, Kenya SCHISTOSOMIASIS IN MINAS GERAIS, BRAZIL Andrea Gazzinelli1, Leonardo F. Matoso1, Ricardo Fujiwara1, João Paulo A. Scientifi c Session 72 Haddad1, Helmut Kloos2, Rodrigo Correa-Oliveira3 1Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, 2University California San Francisco, San Francisco, CA, United States, 3Fundação Oswaldo Cruz, Belo Schistosomiasis and Other Trematodes - Immunology/ Horizonte, Brazil Pathology (ACMCIP Abstract) Washington 1 11:15 a.m.

Friday, November 20, 10:15 a.m. - Noon Friday, November 20 383 CHAIR Stephen Davies SCHISTOSOME SOLUBLE EGG ANTIGENS INDUCE Uniformed Services University of the Health Sciences, Bethesda, MD, United States ERYTHROCYTE CELL DEATH Jonathan D. Kurtis Ravi S. Kasinathan, Robert M. Greenberg Brown University, Providence, RI, United States University of Pennsylvania, Philadelphia, PA, United States 10:15 a.m. 11:30 a.m.

379 384

TIMP-1 IN RESPONSE TO EGG ANTIGENS PREDICTS ENHANCEMENT OF PROTECTIVE IMMUNITY AND HEPATIC FIBROSIS IN HUMAN S. JAPONICUM INFECTION IMMUNO-MODULATION OF LIVER GRANULOMA Valeria Fabre1, Haiwei Wu1, Sunthorn Pond-Tor1, Hannah M. Coutinho1, FORMATION WITH THE COMBINATION OF HUMAN Luz P. Acosta2, Mario A. Jiz1, Remigio M. Olvedo2, Blanca Jarilla2, Stephen AND MICE ANTI-IDIOTYPIC VACCINE MODEL IN T. McGarvey3, Subburaman Mohan4, David Baylink4, Keith Alvares5, Arthur SCHISTOSOMA MANSONI INFECTED MICE Veis5, Jennifer F. Friedman1, Jonathan D. Kurtis1 Mohamed A. Ali, Mohamed Emad Abd El-Fattah 1Center for International Health Research, Providence, RI, United States, 2Research Faculty of Medicine, Minia, Egypt Institute of Tropical Medicine, Manila, Philippines, 3Brown University, Providence, RI, (ACMCIP Abstract) United States, 4Loma Linda University, Loma Linda, CA, United States, 5Northwestern University, Chicago, IL, United States

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11:45 a.m. 11 a.m.

385 389

A NOVEL RECOMBINANT FASCIOLA HEPATICA PROTEIN COMMUNAL AVIAN ROOSTS AS AMPLIFICATION BELONGING TO THE METHYL TRANSFERASE FOCI FOR WEST NILE VIRUS IN URBAN AREAS IN PROTEIN-LIKE FAMILY IS AN USEFUL ANTIGEN FOR NORTHEASTERN USA IMMUNODIAGNOSIS AND A POTENTIAL TARGET FOR Maria A. Diuk-Wasser1, Goudarz Molaei2, Jennifer E. Simpson1, Corrine M. IMMUNOPROPHYLAXIS Folsom1, Philip M. Armstrong2, Theodore G. Andreadis2 1 2 Jose F. Gaudier, Ana M. Espino Yale University, New Haven, CT, United States, The Connecticut Agricultural University of Puerto Rico, Medical Sciences Campus, San Juan, PR, United States Experiment Station, New Haven, CT, United States (ACMCIP Abstract) 11:15 a.m.

Scientifi c Session 73 390

Mosquitoes - Vector Biology - Epidemiology II WEST NILE VIRUS AFFECTS THE RATE OF BLOOD CULEX PIPIENS QUINQUEFASCIATUS Washington 2 DIGESTION IN SAY (DIPTERA: CULICIDAE) Friday, November 20, 10:15 a.m. - Noon Sheri L. Anderson, Stephanie L. Richards, Chelsea T. Smartt, Jonathan F. CHAIR Day University of Florida, Vero Beach, FL, United States Sheri L. Anderson University of Florida, Vero Beach, FL, United States 11:30 a.m. Michael J. Turell United States Army Medical Research Institute for Infectious Diseases, Fort Detrick, 391 MD, United States 10:15 a.m. RELATIONSHIPS BETWEEN MEASURES OF VECTOR COMPETENCE FOR CULEX PIPIENS QUINQUEFASCIATUS 386 (DIPTERA: CULICIDAE) INFECTED WITH WEST NILE VIRUS EVALUATION OF NOVEL DIPSTICK ASSAYS FOR Stephanie L. Richards, Sheri L. Anderson, Cynthia C. Lord, Chelsea T. THE DETECTION OF RIFT VALLEY FEVER VIRUS IN Smartt, Walter J. Tabachnick MOSQUITOES University of Florida, Vero Beach, FL, United States Michael J. Turell1, Kirti Dave2, Sonia Dave2, Maria Mayda3, Zahra Parker3, 11:45 a.m. Russell E. Coleman4, Daniel Strickman5 1 United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, 392 MD, United States, 2VecTOR Test Systems, Inc., Thousand Oaks, CA, United States, 3Walter Reed Army Institute of Research, Silver Spring, MD, United States, 4United States Army Medical Materiel Development Activity, Fort Detrick, MD, United States, EVALUATION OF KENYAN MOSQUITO SPECIES AS 5United States Department of Agriculture, Beltsville, MD, United States VECTORS OF WEST NILE VIRUS Hellen S. Koka1, Micheal Turell2, Joel Lutomiah3, Albina Makio1, Milka 10:30 a.m. Muthoni3, James Mutisya1, Santos Yalwala1, Samson K. Limbaso3, David Schnabel1, Rosemary Sang3 387 1United States Army Medical Research Unit-Kenya, Nairobi, Kenya, 2United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States, USING LUMINEX TO IDENTIFY CULEX BLOODMEALS 3Kenya Medical Research Institute, Nairobi, Kenya AND EVALUATE TRAP BIAS Tara C. Thiemann, William K. Reisen Scientifi c Session 74 University of California, Davis, Davis, CA, United States Flavivirus - Dengue III 10:45 a.m. Washington 3 388 Friday, November 20, 10:15 a.m. - Noon

EPIDEMIOLOGY OF WEST NILE VIRUS IN SOUTHERN CHAIR CALIFORNIA: THE ROLE OF CULEX QUINQUEFASCIATUS Donna Reynolds AND HOUSE FINCHES Sanofi Pasteur, Toronto, ON, Canada Goudarz Molaei1, Robert F. Cummings2, Philip M. Armstrong1, Tianyun Stephen Whitehead Su3, Greg A. Williams4, Min-Lee Cheng3, James P. Webb2, Theodore G. National Institutes of Health, Bethesda, MD, United States Andreadis1 1The Connecticut Agricultural Experiment Station, New Haven, CT, United States, 2Orange County Vector Control District, Garden Grove, CA, United States, 3West Valley Mosquito and Vector Control District, Ontario, CA, United States, 4Northwest Mosquito and Vector Control District, Corona, CA, United States

118 ASTMH 58th Annual Meeting www.astmh.org

10:15 a.m. 11:15 a.m.

393 397

CLINICAL AND PRECLINICAL EVALUATION OF SAFETY AND IMMUNOGENICITY OF A 2-DOSE REGIMEN DENVAX, A TETRAVALENT DEN-2 PDK-53-BASED OF RDEN1Δ30 DENGUE SEROTYPE 1 VACCINE WITH CHIMERIC DENGUE VACCINE BOOSTING AT FOUR VERSUS SIX MONTHS Richard M. Kinney1, Joseph N. Brewoo2, John J. Arguello1, Shawn J. Anna P. Durbin1, Stephen S. Whitehead2, Daniel Elwood1, Wangeci Shilengo1, Tim D. Powell1, Charalambos D. Partidos2, Richard A. Bowen3, Kagucia1, Bhavin Thumar1, Kimberli A. Wanionek1, Dennis Pierro2, Brian R. Betty Luy4, Siritorn Butrapet4, Claire Y.-H. Huang4, Dan T. Stinchcomb1, Murphy2, Alexander C. Schmidt2 Jorge E. Osorio5 1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 1Inviragen, Inc., Fort Collins, CO, United States, 2Inviragen, Inc., Madison, WI, United 2National Institute of Allergy and Infectious Diseases, National Institutes of Health, States, 3Colorado State University, Fort Collins, CO, United States, 4Division of Vector- Bethesda, MD, United States Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States, 5University of Wisconsin, Madison, WI, United States 11:30 a.m.

10:30 a.m. 398

394 POTENTIAL IMPACT OF VACCINATION ON THE TRANSMISSION DYNAMICS OF DENGUE: A FOUR EVALUATION OF NEUTRALIZING ANTIBODY SEROTYPE MODEL RESPONSES AGAINST A LARGE RANGE OF WILD-TYPE Laurent Coudeville, Laurence Pollissard ISOLATES IN SERA OF PRIMATES VACCINATED WITH A Sanofi Pasteur, Lyon, France TETRAVALENT DENGUE VACCINE Veronique Barban1, Yves Girerd1, Nadège Arnaud-Barbe1, Nathalie Mantel1, 11:45 a.m. Sandrine Gulia1, Jorge L. Munoz-Jordan2, Rafaele Dumas1 1Sanofi Pasteur, Marcy L’etoile, France, 2Centers for Disease Control and Prevention, 399 San Juan, PR, United States A SYSTEMATIC LITERATURE REVIEW AND EXPERT 10:45 a.m. PANEL’S ASSESSMENT HEALTH ECONOMICS OF 395 DENGUE Mark E. Beatty1, Philippe Beutels2, Martin I. Meltzer3, Ole Wichmann1, 4 4 5 SAFETY AND IMMUNOGENICITY OF A TETRAVALENT Joachim Hombach , Raymond Hutubessy , Damien Dessis , Laurent Coudeville6, Benoit Dervaux7, Donald S. Shepard8, Harold S. Margolis1, Joel DENGUE VACCINE IN FLAVIVIRUS-NAIVE AND Kuritsky1 -IMMUNE PEDIATRIC POPULATIONS WITH TWO 1International Vaccine Institute, Seoul, Republic of Korea, 2Centre for Health Economics VACCINATION REGIMENS Research and Modeling Infectious Diseases, Centre for the Evaluation of Vaccination,

1 2 1 3 Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium, Denis Crevat , Donna Reynolds , Edith Langevin , Maria R. Capeding 3 4 1Sanofi Pasteur, Marcy L’etoile, France, 2Sanofi Pasteur, Toronto, ON, Canada, Centers for Disease Control and Prevention, Atlanta, GA, United States, World Health 5 3Research Institute for Tropical Medicine, Muntinlupa City, Philippines Organization, Geneva, Switzerland, GlaxoSmithKline Biologicals, Wavre, Belgium, 6Sanofi Pasteur, Lyon, France, 7Universite Catholique de Lille, Lille, France, 8Brandeis 11 a.m. University, Waltham, MA, United States Friday, November 20 396 Symposium 75

CLINICAL EVALUATION OF LIVE ATTENUATED DEN3 Making an Impact on Chagas Disease VACCINE CANDIDATES Washington 4 Stephen S. Whitehead1, Alexander C. Schmidt1, Julie H. McArthur2, Jennifer A. Marron2, Daniel Elwood2, Bhavin Thumar2, Kimberli A. Friday, November 20, 10:15 a.m. - Noon Wanionek2, Dennis Pierro1, Joseph E. Blaney1, Brian R. Murphy1, Anna P. Durbin2 This symposium will include a collection of forward-looking presentations 1Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, targeted at approaches that will impact the detection, treatment and prevention National Institutes of Health, Bethesda, MD, United States, 2Johns Hopkins Bloomberg of Trypanosoma cruzi infection and Chagas disease. The emphasis will be on School of Public Health, Baltimore, MD, United States new tools and how they may be applied. The goal is to raise awareness of recent developments in the fi eld and how these might be applied to control and prevention.

CHAIR Rick L. Tarleton University of Georgia, Athens, GA, United States Ricardo Gurtler University of Buenos Aires, Buenos Aires, Argentina

119 www.astmh.org Detailed Program

10:15 a.m. 10:35 a.m. THE FUTURE OF VECTOR CONTROL EFFORTS IN LESSONS FROM THE FIELD: TWO YEARS OF CHAGAS DISEASE IMPLEMENTING AN INTEGRATED PROGRAM FOR Ricardo Gurtler NEGLECTED TROPICAL DISEASES (NTDS) IN NIGER University of Buenos Aires, Buenos Aires, Argentina Amadou Garba RISEAL Niger, Niamey, Niger 10:40 a.m. PROSPECTS FOR NEW DRUGS FOR CHAGAS DISEASE 10:55 a.m. Julio Urbina LESSONS FROM THE FIELD: TWO YEARS OF Instituto Venezolano de Investigaciones Cientifi cas, Caracas, Venezuela IMPLEMENTING AN INTEGRATED PROGRAM FOR NEGLECTED TROPICAL DISEASES (NTDS) IN UGANDA 11:05 a.m. Narcis B. Kabatereine NEW METHODS FOR ASSESSING TREATMENT Ministry of Health, Kampala, Uganda EFFICACY IN CHRONIC CHAGAS DISEASE 11:15 a.m. Susana Laucella Instituto de Parasitology “Fatala Chaben”, Buenos Aires, Argentina DOES INTEGRATION OF PREVENTATIVE CHEMOTHERAPY REDUCE COST? EXPERIENCE FROM 11:30 a.m. A PROGRAM FOR NEGLECTED TROPICAL DISEASES PROSPECTS AND POTENTIAL FOR VACCINES FOR (NTDS) IN UGANDA PREVENTION OF CHAGAS DISEASE Fiona M. Fleming Rick L. Tarleton Schistosomiasis Control Initiative, Imperial College London, London, United Kingdom University of Georgia, Athens, GA, United States 11:35 a.m. Symposium 76 VISCERAL LEISHMANIASIS IN EASTERN AFRICA: PAST AND PRESENT CONTROL EFFORTS, AND LESSONS FOR Implementation and Evaluation of Neglected Tropical THE FUTURE Disease Control in Sub-Saharan Africa Jan Kolaczinski Malaria Consortium, Kampala, Uganda Washington 5 Friday, November 20, 10:15 a.m. - Noon Scientifi c Session 76A

The Schistosomiasis Control Initiative (SCI) has assisted countries in sub- Saharan Africa since 2003. Initially the support was for schistosomiasis and Malaria - Molecular Biology soil-transmitted control (STH), but has progressed to assisting countries Wilson AB to implement integrated preventive chemotherapy programs for neglected tropical diseases (NTDs). The fi rst speaker will open with a summary of SCI Friday, November 20, 10:15 a.m. - Noon activities to date on schistosomiasis and STD control and discuss involvement in integrated NTD control, why it evolved, how it is being implemented CHAIR and where. This presentation will cover basic principles that are needed Moses Y. Otiende to be considered prior to implementation. The next speakers will illustrate Walter Reed Project/United States Army Medical Research Unit-Kenya, Kisumu, Kenya these general principles in more detail with specifi c country examples and Joanne Thompson experiences of what the main challenges and successes have been after the University of Edinburgh, Edinburgh, United Kingdom fi rst two years of implementation in Niger and Uganda, respectively. These presentations will also highlight innovative program management methods 10:15 a.m. and research that have been carried out. The fi nal speaker will demonstrate the fi nancial and economic costs of implementing an integrated NTD control 372 program, focusing on the cost per person treated and the spatial variation in NTDs present, and hence control packages utilized, across Uganda. PLASMODIUM VIVAX RHOPTRY NECK PROTEIN (PVRON2) Comparisons to vertical programs will be illustrated and potential cost-savings EXPRESSED AT BOTH ERYTHROCYTIC AND PRE- highlighted. ERYTHROCYTIC INVASIVE PARASITES CHAIR Jun Cao1, Osamu Kaneko2, Amporn Thongkukiatkul3, Mayumi Tachibana4, 4 5 1 6 Alan Fenwick Hitoshi Otsuki , Jetsumon Sattabongkot , Qi Gao , Takafumi Tsuboi , 4 Schistosomiasis Control Initiative, Imperial College London, London, United Kingdom Motomi Torii 1Jiangsu Institute of Parasitic Diseases, Wuxi, China, 2Department of Protozoology, Peter J. Hotez Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan, 3Department of The George Washington University, Washington, DC, United States Biology, Faculty of Science, Burapha University, Chonburi, Thailand, 4Department of Molecular Parasitology, Ehime University School of Medicine, Toon, Japan, 5Department 10:15 a.m. of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand, 6 SCI: SETTING THE FRAMEWORK FOR INTEGRATED NTD Cell-Free Science and Technology Research Center, Ehime University, Matsuyama, Japan CONTROL (ACMCIP Abstract) Joanne P. Webster Imperial College London, London, United Kingdom

120 ASTMH 58th Annual Meeting www.astmh.org

10:30 a.m. 11:45 a.m.

373 378

INDIRECT AMINOACYLATION IN THE PLASMODIUM GENOME-WIDE ASSOCIATION AND SELECTION SCANS APICOPLAST IN THE PLASMODIUM FALCIPARUM GENOME Malcolm J. Gardner1, Gowthaman Ramasamy1, Devaraja G. Mudeppa2, Ling Sarah Volkman1, Daniel Neafsey2, Elaine Angelino3, Steve Schaffner2, Danny Li1, Pradipsinh K. Rathod2 Park2, Joseph Cortese2, Kayla Barnes1, Rachel Daniels2, David Rosen1, 1Seattle Biomedical Research Institute, Seattle, WA, United States, 2University of Michele LaRoux1, Daria Van Tyne1, Charles Johnson2, Ousmane Sarr4, Washington, Seattle, WA, United States Souleymane Mboup4, Danny Milner, Jr.1, James Galagan2, Roger Wiegand2, Daniel Hartl3, Bruce Birren2, Eric Lander2, Dyann Wirth1, Pardis Sabeti3 10:45 a.m. 1Harvard School of Public Health, Boston, MA, United States, 2The Broad Institute, Cambridge, MA, United States, 3Harvard University, Cambridge, MA, United States, 374 4Cheikh Anta Diop University, Dakar, Senegal

FUNCTIONAL ANALYSIS OF G-PROTEIN COUPLED Exhibit Hall Open/Light Lunch RECEPTOR HOMOLOGUES IN PLASMODIUM Joanne Thompson, L. Gabriella Lindergard Exhibit Hall A Immunology and Infection Research, Edinburgh, United Kingdom Friday, November 20, Noon - 1:30 p.m. (ACMCIP Abstract) 11 a.m. Poster Session 77/Light Lunch 375 Poster Session B (#400 – 658 and Late Breakers)

A NEW ASSAY FOR SIMULTANEOUS DETECTION OF Exhibit Hall B South MUTATIONS ASSOCIATED WITH PLASMODIUM VIVAX Friday, November 20, Noon - 1:30 p.m. DRUG RESISTANCE Celine Barnadas1, Lincoln Timinao1, Ivo Mueller1, Peter A. Zimmerman2 CLINICAL TROPICAL MEDICINE 1PNG Institute for Medical Research, Goroka, Papua New Guinea, 2Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, United States (ACMCIP Abstract) 400 11:15 a.m. EHRLICHIOSIS: A CASE REPORT FROM LYNCHBURG 376 VIRGINIA James R. Palmieri, Shaadi F. Elswaifi , John Schwartz PRESENCE OF MULTIDRUG RESISTANCE GENE 1 Virginia College of Osteopathic Medicine, Blacksburg, VA, United States (PFMDR1) ALLELES IN P. FALCIPARUM SAMPLES FROM A CLINICAL TRIAL TO TEST TWO ANTIMALARIAL DRUGS 401 IN THE PERUVIAN AMAZON KNOWLEDGE AND PRACTICES AMONG YELLOW FEVER Jorge Bendezu1, Katherine Soto-Cornejo2, Katherine Torres1, Umberto VACCINE PROVIDERS AND CLINICS - PENNSYLVANIA, Friday, November 20 D’Alessandro3, Dionicia Gamboa1 1Instituto de Medicina Tropical “Alexander Von Humboldt”, Universidad Peruana USA, 2008 Cayetano Heredia, Lima, Peru, 2Instituto de Medicina Tropical, Lima, Peru, 3Institute of Mark Gershman1, Betsy Schroeder1, Steve Ostroff2, Perrianne Lurie2, Mark Tropical Medicine “Prince Leopold”, Antwerp, Belgium Lamias1, Pauline Han1, Aimee Ferraro2, Phyllis Kozarsky1, Nina Marano1 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Pennsylvania 11:30 a.m. Department of Health, Harrisburg, PA, United States

377 402

SELECTION OF KNOWN RESISTANCE-MEDIATING 14-3-3β PROTEIN LEVEL IN THE CEREBROSPINAL FLUID POLYMORPHISMS BY ARTEMETHER-LUMEFANTRINE AND SERUM AS AN INDICATOR OF DISEASE ACTIVITIES AND AMODIAQUINE/SULFADOXINE-PYRIMETHAMINE, IN PATIENTS WITH PARASITE-INDUCED EOSINOPHILIC BUT NOT BY DIHYDROARTEMISININ-PIPERAQUINE IN MENINGITIS BURKINA FASO Hung-Chin Tsai, Min-Hon Shi, Pi-Yao Lee, I-Tzu Chen, Po-Shu Lin Anyirekun Fabrice Some1, Yves Sere1, Issaka Zongo1, Noel Rouamba1, Chris Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan Dokomajilar2, Bryan Greenhouse2, Jenny Legac2, Shoba Subramanian2, Jean- Bosco Ouedraogo1, Philip J. Rosenthal2 1Institut de Recherche en Sciences de la Sante, Bobo-Dioulasso, Burkina Faso, 2Department of Medicine, University of California, San Francisco, CA, United States

121 www.astmh.org Detailed Program

403 409

MICROBIOLOGICAL ASPECTS OF EROSIVE-ULCEROUS CLINICAL FACTORS PREDICTIVE OF ENCEPHALITIS LESIONS IN UPPER PART OF THE DIGESTIVE TRACT CAUSED BY ANGIOSTRONGYLUS CANTONENSIS IN PATIENTS WITH LIVER CIRRHOSIS AND PORTAL Kittisak Sawanyawisuth1, Ken Takahashi2, Tsutomu Hoshuyama2, HYPERTENSION Kanlayanee Sawanyawisuth1, Vichai Senthong1, Panita Limpawattana1, 2 1 1 Ravshan A. Ibadov, Leonid G. Bajenov, N. R. Gizatulina, A. Kh. Babadjanov, Donald Wilson , Somsak Tiamkao , Suthipun Jitpimolmard , Verajit Chotmongkol1 G. A. Ibadova 1 2 Republican Specialized Center of Surgery, Tashkent, Uzbekistan Khon Kaen University, Khon Kaen, Thailand, University of Occupational and Environmental Health, Kitakyushu, Japan 404 410 ORIGINAL ANTIBACTERIAL TECHNOLOGY IN THE PREVALENCE OF CHAGAS DISEASE IN U.S. LATIN PROPHYLAXIS AND COMPLEX TREATMENT OF IMMIGRANT POPULATION WITH CONDUCTION PURULENT-INFLAMMATORY DISEASES OF THE LUNGS ABNORMALITIES ON ELECTROCARDIOGRAM AT PATIENTS WITH LONG-TERM OF ARTIFICIAL VENTILATION OF LUNG Sheba K. Meymandi, Salvador Hernandez, Wesam M. Frandah, Haneen Khamag, Aiman M. Smer, Eva Padilla Garcia, Mahmoud I. Traina Ravshan A. Ibadov, L. G. Bajenov, Z. N. Mansurov, Z. A. Shanieva, A. Kh. Olive View-University of California at Los Angeles Medical Center, Sylmar, CA, United Babadjanov, E. V. Rizaeva States Republican Specialized Center of Surgery, Tashkent, Uzbekistan 411 405 COST-EFFECTIVENESS OF INFLUENZA IMMUNIZATION EFFECTIVITY OF DIGESTIVE ORGANS CANDIDIASIS IN ADULT CANCER PATIENTS IN TAIWAN THERAPY BY INDIVIDUAL TESTING DOSES OF Kow-Tong Chen1, Hsiao-Han Lin1, Kan-Lin Hsu1, Winston Wen-Chien Ko2, NYSTATINE Yi-Ching Yang3, Yu-Wei Chang1, Mei-Ching Yu4 N. E. Djumaeva, G. A. Ibadova 1Department of Public Health, College of Medicine, National Cheng Kung University, Scientifi c Research Institute of Epidemiology, Microbiology and Infectious Diseases, Tainan, Taiwan, 2 Division of Infectious Diseases, Department of Internal Medicine, Tashkent, Uzbekistan College of Medicine, National Cheng Kung University, Tainan, Taiwan, 3 Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, 406 Taiwan, 4Department of Chemical Engineering, Tatung University, Taipei, Taiwan

AN ON-SITE SURVEY OF YELLOW FEVER VACCINATION CLINIC PRACTICES - PENNSYLVANIA, USA, 2008 ECTOPARASITE-BORNE DISEASE Betsy Schroeder1, Mark Gershman1, Stephen Ostroff2, Perianne Lurie2, Mark Lamias1, Pauline Han1, Aimee Ferraro2, Phyllis Kozarsky1, Nina Marano1 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Pennsylvania 412 Department of Health, Harrisburg, PA, United States DEVELOPMENT OF A QUANTITATITVE REAL-TIME PCR 407 (QPCR) ASSAY FOR RICKETTSIA PARKERI KETAMINE METABOLISM AND TEST ON EXIT PERSONS Ju Jiang, Allen L. Richards Naval Medical Research Center, Silver Spring, MD, United States SUITABILITY DISCUSSION Huarong Zhang 413 Chongqing International Travel Healthcare Center, Chongqing, China INABILITY OF AMBLYOMMA AMERICANUM LARVAE TO 408 ACQUIRE EHRLICHIA CHAFFEENSIS FROM AN INFECTED DOG PREVALENCE OF CHAGAS DISEASE IN U.S. LATIN AMERICAN IMMIGRANT POPULATION WITH Michael L. Levin, Aubree J. Roche, Lindsay F. Killmaster, Galina E. Zemtsova, William L. Nicholson CARDIOMYOPATHY Centers for Disease Control and Prevention, Atlanta, GA, United States Mahmoud I. Traina, Salvador Hernandez, Aiman M. Smer, Wesam M. Frandah, Haneen Khamag, Eva Padilla Garcia, Sheba K. Meymandi 414 Olive View-University of California at Los Angeles Medical Center, Sylmar, CA, United States GENETIC RELATIONSHIPS OF 364D AND HLP#2 SEROTYPES TO RICKETTSIA RICKETTSII Gregory A. Dasch1, Marina E. Eremeeva1, Lauren K. Robinson1, Kathryn Dirks1, Frankie H. White1, Maria L. Zambrano1, Cecilia Kato1, Kevin Tang1, David C. Bruce2, A. Chris Munk2, J. Chris Detter2, Thomas S. Brettin2 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Joint Genome Institute, Los Alamos National Laboratory, Los Alamos, NM, United States

122 ASTMH 58th Annual Meeting www.astmh.org

415 FLAVIVIRIDAE - DENGUE

TEMPORAL PATTERNS OF EARLY CYTOKINE IMMUNE RESPONSE TO INFECTION WITH B. BURGDORFERI 422

1 2 3 1 John Aucott , Alison Schwarzwalder , Alexi Miagkov , Mark Soloski ANTIBODY DETERMINANTS OF PROTECTION AND 1Johns Hopkins School of Medicine, Baltimore, MD, United States, 2Lyme Disease Research Foundation of Maryland, Lutherville, MD, United States, 3Caliper Life ENHANCEMENT OF SECONDARY DENGUE VIRUS Sciences, Hanover, MD, United States INFECTION IN VITRO AND IN VIVO Katherine L. Williams1, Ruben Lachica1, Diana Flores1, Wahala Wahala2, 416 Aravinda M. de Silva2, Martina Beltramello3, Federica Sallusto3, Antonio Lanzavecchia3, P. Robert Beatty1, Eva Harris1 MOLECULAR EPIDEMIOLOGY OF POWASSAN VIRUS 1Division of Infectious Diseases and Vaccinology, School of Public Health, University 2 IN NORTH AMERICA: BAYESIAN ANALYSES REVEAL of California, Berkeley, Berkeley, CA, United States, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, United States, 3Institute STABLE POPULATION SIZES THROUGH TIME for Research in Biomedicine, Bellinzona, Switzerland Kendra Pesko, Fernando Torres-Perez, Gregory Ebel University of New Mexico, Albuquerque, NM, United States 423

417 DIFFERENCES IN CLINICAL PRESENTATION AND RELATION TO IMMUNE STATUS AMONG DENGUE DISTRIBUTION OF SPOTTED FEVER-GROUP VIRUS SEROTYPES IN A HOSPITAL-BASED STUDY IN RICKETTSIAE IN CANINES FROM TENNESSEE NICARAGUA 1 2 1 1 Meghan E. Rowland , Jenny G. Maloney , Junjun Huang , John R. Dunn , 1 1 2 1 1 1 1 Sheyla Silva , Crisanta Rocha , Gamaliel Gutierrez , Federico Narvaez , Rand Carpenter , Timothy F. Jones , Abelardo C. Moncayo 3 2 2 3 1 2 Andrea Nuñez , Douglas Elizondo , Katherine Standish , Angel Balmaseda , Tennessee Department of Health, Nashville, TN, United States, Middle Tennessee State Eva Harris4 University, Murfreesboro, TN, United States 1Hospital Infantil Manuel Jesús de Rivera, Managua, Nicaragua, 2Sustainable Sciences Institute, Managua, Nicaragua, 3Departamento de Virología, Centro Nacional 418 de Diagnóstico y Referencia, Ministerio de Salud, Managua, Nicaragua, 4Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, EFFECTS OF FLEA FEEDING ON EARLY INNATE Berkeley, Berkeley, CA, United States IMMUNE EVENTS IN THE SKIN AND TRANSMISSION OF YERSINIA PESTIS 424 Christopher F. Bosio, Clayton O. Jarrett, B. Joseph Hinnebusch Rocky Mountain Laboratories, Hamilton, MT, United States PHYLOGEOGRAPHY AND MOLECULAR EVOLUTION OF DENGUE VIRUS TYPE 1 IN PUERTO RICO, 1981-1998 419 Brandi A. Mueller1, Maya Paidi1, Orchid Allicock2, Christine V. Carrington2, Duane J. Gubler1, Shannon N. Bennett1 INFECTION RATES OF THE TRIATOMINE BUG TRIATOMA 1University of Hawaii at Manoa, Honolulu, HI, United States, 2University of the West Indies, St. Augustine, Trinidad and Tobago RUBIDA WITH TRYPANOSOMA CRUZI, THE CAUSATIVE AGENT OF CHAGAS DISEASE, IN THE TUCSON AREA OF 425 ARIZONA Carolina E. Reisenman1, Gena G. Lawrence2, Pablo G. Guerenstein1, Teresa

TRANSFORMING MODELS INTO USER-FRIENDLY Friday, November 20 1 2 1 Gregory , Ellen M. Dotson , John G. Hildebrand PROGRAMS FOR EVALUATING DISEASE CONTROL 1Arizona Research Laboratories, University of Arizona, Tucson, AZ, United States, 2Centers for Disease Control and Prevention, Atlanta, GA, United States STRATEGIES AT THE LOCAL SCALE Alicia Ellis1, Dana Focks2, Andy Garcia1, Thomas Scott1 420 1University of California - Davis, Davis, CA, United States, 2Infectious Disease Analysis, Gainesville, FL, United States GEOGRAPHICAL ASSESSMENT OF RICKETTSIAL 426 INFECTIONS IN RODENTS IN INDONESIA

1 1 2 1 Susana Widjaja , Maya Williams , Ima N. Ibrahim , Imelda L. Winoto , Arik DENGUE VIRUS SEROPREVALENCE AND Farzeli1, Andre Yunianto2, Dian Perwitasari2, Ungke A. Jaya1, Deni Pepi1, Allen L. Richards3, Katie A. Barbara1, Craig A. Stoops1, Patrick J. Blair1 SEROINCIDENCE AMONG KENYAN CHILDREN 1United States Naval Medical Research Unit 2, Jakarta, Indonesia, 2National Health Jason M. Blaylock1, Ashley M. Maranich1, Kristen Bauer2, Mark Polhemus3, Research and Development, Ministry of Health, Jakarta, Indonesia, 3Naval Medical Luis J. Martinez2, Jitvimal Seriwatana2, John Waitumbi3, Douglas Walsh3, Research Center, Silver Spring, MD, United States Julia Lynch2 1Walter Reed Army Medical Center, Washington, DC, United States, 2Walter Reed Army 421 Institute of Research, Silver Spring, MD, United States, 3United States Army Medical Research Unit - Kenya, Kenya Medical Research Unit, Walter Reed Project, Kisumu, Kenya AFRICAN TICK-BITE FEVER IN A TAIWANESE TRAVELER RETURNING FROM SOUTH AFRICA: MOLECULAR AND SEROLOGICAL STUDIES Kun-Hsien Tsai Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan

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MOLECULAR EPIDEMIOLOGY OF DENV-1 ISOLATED STUDIES OF VECTOR COMPETENCE IN AEDES AEGYPTI IN MARACAY, VENEZUELA, DURING 1997 - 2007: A WITH COLOMBIAN STRAINS OF DENGUE VIRUS: PROBABLE CLADE REPLACEMENT EVENT EVALUATION OF SINGLE AND MIXED INFECTIONS Guillermo Comach1, Daria Camacho1, Francisco Rodriguez-Henriquez2, Carolina Quintero-Gil1, Marlen Martinez-Gutierrez1, Francisco Díaz2, Marta Gloria Sierra1, Irene Bosch3, Diane Schmidt3, Antonio Tenorio4, Tadeusz J. Ospina3, Oladier Hoyos1, Jorge Osorio4 Kochel5 1Programa de Estudio y Control de Enfermedades Tropicales-PECET, Universidad de 1U. de Carabobo/Biomed-Lardidev/Corposalud, Maracay, Venezuela, 2U. de Carabobo/ Antioquia, Medellin, Colombia, 2Grupo de Inmunovirologia, Universidad de Antioquia, Biomed, Maracay Venezuela, 3Center for Infectious Disease and Vaccine Research, Medellin, Colombia, 3Laboratorio Departamental de Salud de Antioquia, Medellin, University of Massachusetts Medical School, Worcester, MA, United States, 4Laboratorio Colombia, 4Department of Pathobiological Sciences, School of Veterinary Medicine, de Arbovirus/Centro Nacional de Microbiologia/Instituto de Salud Carlos III/Ministerio University of Wisconsin, Madison, WI, United States de Sanidad y Consumo, Madrid, Spain, 5United States Naval Medical Research Center Detachment, Lima, Peru 433

428 MODELING DENGUE CASES IN HEALTH REGIONS OF COSTA RICA USING EL NIÑO SOUTHERN OSCILLATION IMINOSUGAR NB-DNJ DELAYS MORTALITY IN LETHAL AND LOCAL VEGETATION DYNAMICS MODEL OF DENGUE VIRUS INFECTION IN MICE Adriana Troyo1, Douglas O. Fuller2, John C. Beier2 P. Robert Beatty1, Joanna Miller2, Stephanie Pollack2, Ruben Lachica1, 1Universidad de Costa Rica, San Jose, Costa Rica, 2University of Miami, Coral Gables, Katherine L. Williams1, Nicole Zitzmann2, Eva Harris1 FL, United States 1Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States, 2Oxford Glycobiology Institute, 434 Department of Biochemistry, University of Oxford, Oxford, United Kingdom

429 DENV-3 GENOTYPE III IS CIRCULATING IN SÃO PAULO STATE, BRAZIL, DURING THE LAST FIVE YEARS, AND DENGUE VIRUS PROTEASE NS2B/NS3 WITH A IT HAS NOT BEEN ASSOCIATED WITH THE SEVERE POTENTIAL INHIBITION OF THE TOLL-LIKE RECEPTOR PRESENTATIONS OF THE DISEASE 3 SIGNALING PATHWAY Luiza A. Castro-Jorge, Daniel M. Jorge, Benedito A. Fonseca School of Medicine of Ribeirão Preto, Ribeirão Preto, S.P., Brazil Yesseinia I. Anglero1, Petraleigh Pantoja2, Gabriel Gracia3, Carlos A. Sariol4 1University of Puerto Rico, School of Medicine, Microbiology and Medical Zoology Department, San Juan, Rio Piedras, PR, United States, 2University of Puerto Rico, 435 School of Medicine, UCM-CPRC, San Juan, Rio Piedras, PR, United States, 3University of Puerto Rico, Rio Piedras, Biology Department, San Juan, Rio Piedras, PR, United SPATIO-TEMPORAL PATTERN OF DENGUE VIRUS States, 4University of Puerto Rico, School of Medicine, Microbiology and Medical Zoology SPREAD IN URBAN CAIRNS, AUSTRALIA Department, UCM-CPRC; Internal Medicine Department, San Juan, Rio Piedras, PR, Gonzalo M. Vazquez-Prokopec1, Scott Ritchie2, Jeffrey Hanna2, Peter United States Horne2, Brian Montgomery2, Uriel Kitron1 1Emory University, Atlanta, GA, United States, 2Tropical Population Health Services, 430 Queensland Health, Cairns, Australia

EFFECT OF FcγRII ISOFORMS ON ANTIBODY 436 DEPENDENT ENHANCEMENT OF DENGUE VIRUS INFECTION INVOLVING A LOCAL COMMUNITY NETWORK WITHIN Kobporn Boonnak, Bonnie M. Slike, Mary A. Marovich A LARGE SCALE, TETRAVALENT DENGUE VACCINE The Henry M. Jackson Foundation, Rockville, MD, United States EFFICACY TRIAL IN THAILAND Anh Wartel-Tram1, Chukiat Sirivichayakul2, Pornthep Chanthavanich2, Ole 431 Wichmann3, Arunee Sabchareon2 1Sanofi Pasteur, Singapore, Singapore, 2Faculty of Tropical Medicine, Mahidol COMPARISON OF NEUTRALIZING AND ENHANCING University, Bangkok, Thailand, 3Pediatric Dengue Vaccine Initiative, Seoul, Democratic TITERS OF PATIENT AND VACCINEE SERA USING People’s Republic of Korea A HIGH-THROUGHPUT DENGUE REPORTER VIRUS DETECTION SYSTEM 437

1 1 1 Bridget A. Puffer , Kimberly-Anne Mattia , Emily M. Sluzas , Meridith R. DEVELOPMENT OF SANOFI PASTEUR’S RECOMBINANT Murray1, Eva Harris2, Benjamin J. Doranz1 1Integral Molecular, Philadelphia, PA, United States, 2University of California, Berkeley, LIVE-ATTENUATED TETRAVALENT DENGUE VACCINE: Berkeley, CA, United States 2009 UPDATE Rafaela Dumas, Melanie Saville, Bruno Guy, Jean Lang Sanofi Pasteur, Marcy l’etoile, France

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INTERFERENCE IN VIRAL REPLICATION BETWEEN DENGUE SEROTYPES IN CO-INFECTION OF AN 444 INTERFERON DEFICIENT CELL LINE William O. Hahn, Timothy P. Endy EFFECTS OF INTEGRATION OF NEGLECTED TROPICAL SUNY Upstate Medical University, Syracuse, NY, United States DISEASE INTERVENTIONS ON VOLUNTEER HEALTH (ACMCIP Abstract) WORKER WORK-TIME IN NIGERIA Kathryn Welter1, Deborah McFarland1, Darin Evans2, John Umaru3, Abel 439 Eigege3, Priscillia Dewa3 1Rollins School of Public Health, Emory University, Atlanta, GA, United States, 2The MUNICIPALITIES IN PUERTO RICO WITH HISTORY OF Carter Center, Atlanta, GA, United States, 3The Carter Center, Jos, Nigeria HIGH INCIDENCE RATES OF DENGUE José M. Calderón-Squiabro1, Marisol Peña-Orellana1, Fermín Arguello,1, 445 Gustavo Dayan2, Kay Tomashek1 1Centers for Disease Control and Prevention, San Juan, Puerto Rico, 2Sanofi -Pasteur, PERCEPTIONS ABOUT HEALTH PROCESSES AMONG Swiftwater, PA, United States COMMUNITY MEMBERS FROM SMALL RIVERINE POPULATIONS IN THE PERUVIAN RAINFOREST 440 Angela M. Bayer1, Cinthia M. Carhuas1, Juan F. Sanchez1, Martín Beltran2, Hugo R. Razuri1, Carol Zavaleta3, Eric S. Halsey4, Joel M. Montgomery1, DENGUE INFECTION AMONG SCHOOL-AGED John W. Sanders1, Andres G. Lescano1 CHILDREN AND ADOLESCENTS IN PATILLAS, PUERTO 1United States Naval Medical Research Center Detachment, Lima, Peru, 2Peruvian RICO: RESULTS OF A PROSPECTIVE SEROTYPE- Ministry of Health, Yurimaguas, Peru, 3National Center of Intercultural Health, 4 SPECIFIC INCIDENCE STUDY, 2007 Peruvian Ministry of Health, Lima, Peru, United States Air Force Wright-Patterson Medical Center, Wright-Patterson Air Force Base, OH, United States D. Fermín Argüello1, Luz Quiñones1, Kay Tomashek1, Manuela Beltran1, Luz Acosta1, Heidi Acosta1, Patricia Cano2, Enid Garcia2, Laurence Pollissard3, 446 Christine Luxemburger3, Elizabeth Hunsperger1 1Centers for Disease Control and Prevention, San Juan, PR, United States, 2Puerto Rico Department of Health, San Juan, PR, United States, 3Sanofi Pasteur, Lyon, France PREVALENCE OF INTESTINAL PARASITES, ANEMIA AND MALARIA IN SMALL RIVERINE POPULATIONS IN THE 441 PERUVIAN RAINFOREST Juan F. Sanchez1, Angela M. Bayer1, Victor E. Gonzaga1, Connie Fernandez1, EARLY IMMUNOLOGICAL CHANGES IN DENGUE VIRUS Martín Beltran2, Hugo R. Razuri1, Tadeusz Kochel1, Paul C. Graf1, Kirk INFECTED RHESUS MACAQUES D. Mundal1, Carol Zavaleta3, Eric S. Halsey4, Ryan C. Maves1, Joel M. Montgomery1, John W. Sanders1, Andres G. Lescano1 Guey Chuen Perng, Nattawat Onlamoon, Sansanee Noisakran, Hui-Mien 1United States Naval Medical Research Center Detachment, Lima, Peru, 2Peruvian Hsiao, Francois Villinger, Aftab A. Ansari Ministry of Health, Yurimaguas, Peru, 3National Center of Intercultural Health, Emory University School of Medicine, Atlanta, GA, United States Peruvian Ministry of Health, Lima, Peru, 4United States Air Force Wright-Patterson Medical Center, Wright-Patterson Air Force Base, OH, United States 442 447 DENGUE ECONOMIC BURDEN IN THE AMERICAS: ESTIMATES FROM DENGUE ILLNESS THE EFFECT OF WILDLIFE TRANSMISSION ON RABIES Friday, November 20 Laurent Coudeville1, Donald S. Shepard2, Betzana Zambrano3, Gustavo VACCINATION THRESHOLDS IN TANZANIA 3 Dayan Meagan C. Fitzpatrick1, Stephen Davis1, Katie Hampson2, Sarah Cleaveland3, 1 2 Sanofi Pasteur, Lyon, France, Brandeis University, Waltham, MA, United States, Jeffrey P. Townsend1, Alison P. Galvani1 3 Sanofi Pasteur, Swiftwater, PA, United States 1Yale University, New Haven, CT, United States, 2University of Sheffi eld, Sheffi eld, United Kingdom, 3University of Glasgow, Glasgow, United Kingdom 443 448 DENGUE MENINGOENCEPHALITIS IN INDIA AND BANGLADESH STRENGTHENING MANAGEMENT CAPACITY Jaimie S. Robinson1, Robert S. Lanciotti1, Marc Fischer1, David OF PERSONNEL INVOLVED IN INTEGRATED Featherstone2, Ravi Vasanthapuram3, Anita Desai3, Nalini Ramamurty4, INTERVENTIONS FOR NEGLECTED TROPICAL 5 6 6 Anwarul Haque Chowdhury , Hardeep Sandhu , Kathleen F. Cavallaro , DISEASE (NTD) TO SUPPORT A MORE EFFECTIVE Barbara W. Johnson1 1Centers for Disease Control and Prevention, Fort Collins, CO, United States, 2World END EFFICIENT DELIVERY OF INTEGRATED Health Organization, Geneva, Switzerland, 3NIMHANS, Bangalore, India, 4WHO- INTERVENTIONS IN THE NIGERIA SEARO, New Delhi, India, 5IPH, Dhaka, Bangladesh, 6Centers for Disease Control and Josef Amann1, Janna Brooks1, Emmanual Miri2, Abel Eigege2, Priscillia Prevention, Atlanta, GA, United States Dogonyaro2, Deb McFarland3, Frank Richards4 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2The Carter Center, Jos, Nigeria, 3Emory University, Atlanta, GA, United States, 4The Carter Center, Atlanta, GA, United States

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FEMALE GENITAL MUTILATION, ATTITUDE AND APPLICATION OF HIGH DENSITY RESEQUENCING PRACTICES - A CASE STUDY IN RURAL GHANA MICROARRAY RPM-TEI V. 1.0 FOR ANALYSIS OF SOIL Samuel A. Abariga AND DUST SAMPLES FROM THE MIDDLE EAST Tufts Medical Center, Boston, MA, United States Tomasz A. Leski, Michael Gregory, Baochuan Lin, Anthony Malanoski, David Stenger 450 Naval Research Laboratory, Washington, DC, United States

TOWARDS INTEGRATION OF NTD PROGRAMS IN 456 TANZANIA: COORDINATION, COLLABORATION OR CONSOLIDATION? VIRUS ECOLOGY AND GLOBAL HEALTH: THE SHOPE Mwele N. Malecela1, Peter Kilima2, Upendo Mwingira1, Bernard Kilembe1, LEGACY Mbutolwe Mwakitalu1, Ursuline Nyandindi3, Charles D. Mackenzie4, Oscar Richard Shope Kaitaba3, Edward Kirumbi3, Peter Mmbuji3, Donan Mmbando3, Edwin Loyola Marymount University, Los Angeles, CA, United States Michael5 1National Institute for Medical Research, Dar-es-salaam, United Republic of Tanzania, 457 2Public Health Consultant, Dar-es-salaam, United Republic of Tanzania, 3Ministry of Health and Social Welfare, Dar-es-salaam, United Republic of Tanzania, 4Michigan THE ROLE OF COMMUNICATION SCHOLARSHIP IN THE State University, East Lansing, MI, United States, 5Imperial College School of Medicine, London, United Kingdom PREVENTION AND CONTROL OF DISEASES OF GLOBAL IMPORT 451 Margaret Ann Romoser1, Patrice M. Buzzanell2, Lynn M. Harter1, Gary L. Kreps3, Arvind Singhal4, Emily Zielinski-Gutierrez5 UNDER-UTILIZATION OF HEALTH CARE SERVICES 1Ohio University, Athens, OH, United States, 2Purdue University, West Lafayette, IN, 3 4 FOR INFECTIOUS DISEASE SYNDROMES IN RURAL United States, George Mason, Fairfax, VA, United States, University of Texas, El Paso, TX, United States, 5Centers for Disease Control and Prevention, Ft. Collins, CO, AZERBAIJAN United States Danielle V. Clark1, Afrail Ismayilov2, Sevinj Bakhishova2, Huseyn Hajiyev2, Tahir Nuriyev3, Saleh Piraliyev3, Sadigulla Bagirov3, Afag Aslanova4, Maqsud Qasimov2, Matthew J. Hepburn5 HELMINTHS – NEMATODES – INTESTINAL 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2Anti- NEMATODES Plague Station, Baku, Azerbaijan, 3Center for Hygiene and Epidemiology, Quba, Qusar, Xachmaz, Azerbaijan, 4Raytheon Technical Services Company, Baku, Azerbaijan, 5United States Army Research Institute for Infectious Diseases, Fort Detrick, MD, 458 United States SPATIAL HETEROGENEITY OF SOIL-TRANSMITTED 452 HELMINTHS: IMPLICATIONS FOR RAPID ASSESSMENT AND CONTROL SOCIAL CHANGE, ASTHMA AND ALLERGY IN LATIN Hugh J. Sturrock1, Pete W. Gething2, Archie C. Clements3, Jan H. AMERICA (SCAALA): PRELIMINARY FINDINGS Kolaczinski4, Narcis B. Kabatereine5, Simon Brooker1 Philip Cooper1, Laura C. Rodrigues2, Neuza Alcantara-Neves3, Alvaro Cruz3, 1London School of Hygiene and Tropical Medicine, London, United Kingdom, 2Oxford Mauricio L. Barreto3 University, Oxford, United Kingdom, 3School of Population Health, University of 1Instituto de Microbiologia, Universidad San Francisco de Quito, Ecuador, 2Department Queensland, Brisbane, Australia, 4Malaria Consortium Africa, Kampala, Uganda, of Epidemiology, London School of Hygiene and Tropical Medicine, United Kingdom, 5Vector Control Division, Ministry of Health Uganda, Kampala, Uganda 3Federal University of Bahia, Salvador, Brazil 459 453 EFFICACY OF MASS DRUG ADMINISTRATION (MDA) COST EFFICIENCIES OF NTD INTEGRATION OF ALBENDAZOLE IN THE REDUCTION OF SOIL Deborah McFarland1, Darin Evans2, William Adamani3, David Alheri3, Abel TRANSMITTED HELMINTH INFECTION IN SOUTH Eigege3, Emmanuel Miri3, Frank Richards2 INDIA: COMPARISON OF DATA FROM TWO ADJACENT 1 2 Rollins School of Public Health of Emory University, Atlanta, GA, United States, The DISTRICTS OF TAMIL NADU Carter Center, Atlanta, GA, United States, 3The Carter Center/Nigeria, Jos, Nigeria Deepthi Kattula, Shantidani Minz, Sitara S. Ajjampur, Jayaprakash Muliyil, 454 Gagandeep Kang Christian Medical College, Vellore, Tamil Nadu, India

DETERMINANTS OF UTILIZATION OF OUTPATIENT 460 HEALTH CARE IN GHANA Samuel A. Abariga GENDER, AGE AND SOIL-TRANSMITTED HELMINTH Tufts Medical Center, Boston, MA, United States INFECTIONS IN EARLY CHILDHOOD Theresa W. Gyorkos McGill University, Montreal, QC, Canada

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ANTHELMINTHIC USE IN THE FIRST TRIMESTER: HUMAN CHRONIC INFECTIONS WITH ASCARIS LIMITATIONS OF CURRENT EVIDENCE AND LUMBRICOIDES AFFECT CYTOKINE PRODUCTION AND IMPLICATIONS FOR LARGE SCALE DEWORMING GENE EXPRESSION PROGRAMS Philip J. Cooper1, Fernanda Schreiber2, Miguel Reina1, Susana Benitez1, Theresa W. Gyorkos Nely Broncano1, Martha E. Chico1, Gordon Dougan2 McGill University, Montreal, QC, Canada 1Laboratorio de Investigaciones FEPIS, Quininde, Ecuador, 2Wellcome Trust Sanger Institute, Hinxton, United Kingdom 462 468 REDUCTION IN HOOKWORM INTENSITY OF INFECTION FOLLOWING TREATMENT WITH PRAZIQUANTEL IN A NOVEL AND POWERFUL CLASS OF NEMATICIDES LEYTE, THE PHILIPPINES FOR SOIL-TRANSMITTED NEMATODE INFECTIONS Nitin Aggarwal1, Stephen T. McGarvey2, Luz P. Acosta3, Mario A. Jiz4, Yan Hu, Sophia Georghiou, Alan Kelleher, Cheng-Yuan Kao, Chang-Shi Tjalling Leenstra4, Hannah M. Coutinho4, Remigio M. Olveda3, Jonathan D. Chen, Raffi V. Aroian Kurtis5, Jennifer F. Friedman6 University of California, San Diego, La Jolla, CA, United States 1Alpert Medical School of Brown University, Providence, RI, United States, 2Epidemiology Section, Department of Community Health and International Health Institute, Brown 469 University, Providence, RI, United States, 3Research Institute for Tropical Medicine, Manila, Philippines, 4Center for International Health Research, Rhode Island Hospital, CHARACTERIZATION OF THE IMMUNE RESPONSE TO Providence, RI, United States, 5Center for International Health Research, Rhode Island THE LARVAL PHASE OF ASCARIS SUUM INFECTION AND Hospital, Department of Pathology and Laboratory Medicine, Alpert Medical School IDENTIFICATION OF ASCARIS ANTIGENS EXPRESSED of Brown University, Providence, RI, United States, 6Center for International Health Research, Rhode Island Hospital, Department of Pediatrics, Alpert Medical School of DURING THAT PHASE Brown University, Providence, RI, United States Maria A. Garcia Fernandez1, Henry J. Pollack1, Daniel Eichinger2, Peter J. Hotez3 463 1NYU School of Medicine, Division Pediatric Infectious Diseases, New York, NY, United States, 2NYU School of Medicine, Department Medical Parasitology, New York, NY, 3 CATHEPSIN B- AND L-LIKE CYSTEINE PROTEASE United States, Sabin Vaccine Institute; Department Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC, United States ACTIVITIES DURING THE IN VITRO DEVELOPMENT OF HYSTEROTHYLACIUM ADUNCUM (NEMATODA: ANISAKIDAE), A WORLDWIDE FISH PARASITE HIV AND CO-INFECTIONS David Malagón1, Manuel Díaz-López2, Rocío Benítez1, Francisco Javier Adroher1 470 1Department of Parasitology, Faculty of Pharmacy, University of Granada, Granada, 2 Spain, Departamento de Biología Aplicada, Escuela Politécnica Superior, Universidad de EFFICACY OF SECOND-LINE THERAPY (PROTEASE Almería, Almería, Spain INHIBITOR BASE-REGIME) AFTER NON NUCLEOSIDE 464 REVERSE TRANSCRIPTASE INHIBITOR (NNRTI) BASED HIV TREATMENT FAILURE INTENSITY AND PREVALENCE OF SOIL TRANSMITTED Supat Chamnanchanunt HELMINTHS IN HAITIAN COMMUNITIES Tropical Medicine, Bangkok, Thailand Friday, November 20

1 2 3 1 Aissatou Diawara , Ray Kaplan , Patrick Lammie , Roger Prichard 471 1McGill University, Montreal, QC, Canada, 2University of Georgia, Athens, GA, United States, 3Centers for Disease Control and Prevention, Atlanta, GA, United States EFFECT OF HIV-1 SUBTYPES A AND D ON DISEASE 466 PROGRESSION IN HIV INFECTED PATIENTS WITH SEPSIS IN UGANDA ACCIDENTAL FINDING OF A LIVE ANISAKID Najah I. Doka1, Christopher C. Moore1, Shevin T. Jacob2, David Meya3, NEMATODE (ASCARIDIDA: HETEROCHEILIDAE) Harriet Mayanja-Kizza3, Patrick Banura3, Steve Reynolds3, Michael Scheld1, IN FRESH MARKET COD FISH FROM AN ATLANTA Wen Yuan1 1University of Virginia, Charlottesville, VA, United States, 2University of Washington, GROCERY STORE AND ITS IMPLICATION IN PUBLIC Seattle, WA, United States, 3Makerere University, Infectious Disease Institute, Uganda HEALTH Henry Bishop1, Blaine A. Mathison2, Stephanie P. Johnston1, Jeffrey 472 L. Jones1, Mark L. Eberhard1, Rebecca Bandea2, Norman J. Pieniazek1, 1 Alexandre J. da Silva HIV DISEASE AND BLOODSTREAM INFECTIONS 1Centers for Disease Control and Prevention-NCZVED-Division of Parasitic Diseases, Atlanta, GA, United States, 2The Atlanta Education and Research Foundation, Decatur, AMONG FEBRILE PEDIATRIC HOSPITAL ADMISSIONS GA and Centers for Disease Control and Prevention-NCZVED-Division of Parasitic IN NORTHERN TANZANIA Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States John A. Crump1, Habib O. Ramadhani2, Anne B. Morrissey1, Levina Msuya2, (ACMCIP Abstract) Grace D. Kinabo2, Werner Schimana2, Coleen K. Cunningham1, John A. Bartlett1, Hugh Reyburn3 1Duke University Medical Center, Durham, NC, United States, 2Kilimanjaro Christian Medical Centre, Moshi, United Republic of Tanzania, 3London School of Hygiene and Tropical Medicine, London, United Kingdom

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THE EFFECT OF AIDS BEHAVIORAL INTERVENTION ON CONCOMITANT-DISTANT LESIONS AS A POTENTIAL CHINESE OVERSEAS WORKERS RISK FACTOR FOR ANTIMONY TREATMENT FAILURE IN Ruixin Hu ULCERATED CUTANEOUS LEISHMANIASIS IN PERU Liaoning International Travel Healthcare Center, Shenyang, China Cristian R. Valencia von Humboldt Institute of Tropical Medicine, Lima, Peru 474 480 MOLECULAR CHARACTERIZATION OF HIV-1 IN NICARAGUA INSULIN-LIKE GROWTH FACTOR-1 ENHANCES THE Gladys Carrion1, V. Alberto Laguna-Torres1, Felix Sanchez2, Miguel Orozco3, INNATE IMMUNE RESPONSE OF MACROPHAGES FROM Manuel Alfaro3, Roberto Cieza1, Tadeusz Kochel1 WELL-NOURISHED MICE BUT CAN NOT RECTIFY THE 1Naval Medical Research Center Detachment, Lima, Peru, 2Ministerio de Salud, DEFECTIVE IMMUNE RESPONSE OF MACROPHAGES 3 Managua, Nicaragua, Centro de Investigaciones y Estudios de la Salud (CIES), FROM MALNOURISHED MICE Managua, Nicaragua Gregory M. Anstead, Qiong Zhang, Peter C. Melby 475 South Texas Veterans Healthcare System, San Antonio, TX, United States 481 DECREASED ANTIVIRAL ANTIBODY RESPONSES IN SHIV1157IP-INFECTED RHESUS MACAQUES A COHORT-BASED STUDY OF LEISHMANIA MAJOR COINFECTED WITH SCHISTOSOMA MANSONI INFECTION AND CUTANEOUS LEISHMANIASIS IN MALI 1 1 2 2 SuFey Ong , S. Michele Owens , Agnes L. Chenine , Ruth M. Ruprecht , W. 1 2 3 1 Seydou Doumbia , Ousmane Faye , Fabiano Oliveira , Jennifer M. Evan Secor 3 2 1 2 1Centers for Disease Control, Atlanta, GA, United States, 2Harvard University, Anderson , Pierre Traore , Souleymane Diarra , Koureissi Tall , Ibrahim M Sissoko1, Daouda Diallo1, Sibiry Samake1, Cheick Amadou Coulibaly1, Cambridge, MA, United States 1 3 3 1 (ACMCIP Abstract) Bourama Traore , Clarissa Teixeira , Regis Gomez , Constance Soucko , Phil Lawyer3, Somita Keita2, Rick Fairhurst3, Shaden Kamhawi3, Jesus L Valenzuela3 476 1Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Odonto- stomatology, University of Bamako, Bamako, Mali, 2Centre National d’Appui a la PREVIOUS EXPOSURE WITH CEPHALOSPORINS AND lutte contre la Maladie (CNAM), Bamako, Mali, 3Laboratory of Malaria and Vector MACROLIDES BUT NOT COTRIMOXAZOLE AS A RISK Research, National Institute of Allergy and Infectious Diseases, National Institutes of FACTOR FOR COLONIZATION WITH MRSA IN HIV- Health, Rockville, MD, United States INFECTED CHILDREN 482 Andrea Kalavska, Vladimir Krcmery, Anna Liskova St. Elizabeth University College of Health and Social Sciences, Bratislava, Slovakia TRYPANOSOMA EVANSI ANTIBODY LEVELS IN SOME 477 EDIBLE FISHES IN KOLKATA, INDIA Satadal Das1, Anindita Bar2, Bhaskar Sarkar2, Rima Naskar2, Rima Mandal2, MOLECULAR CHARACTERIZATION OF Pulak Lahiri2 1Das Research Centre and Clinical Laboratory, Kolkata, India, 2Department of Zoology, CRYPTOSPORIDIUM ISOLATED FROM HIV-INFECTED Calcutta University, Kolkata, India PATIENTS IN MALAYSIA Johari Surin1, Asma Iqbal1, Mohammed Mahdy1, Benedict Sim2, Adeeba 483 Kamarudin1, Yvonne Lim1 1 2 University of Malaya, Kuala Lumpur, Malaysia, Hospital Sungai Buloh, Selangor, NOVEL PRIMARY MEANS OF TRANSMISSION OF Malaysia VISCERAL LEISHMANIASIS (ACMCIP Abstract) Kyle Metz1, Mark Madsen2, Katherine Gibson-Corley2, Paola Boggiatto2, Marcelo Ortigao3, Lyric Bartholomay2, Christine A. Petersen2 KINETOPLASTIDA - EPIDEMIOLOGY 1Johns Hopkins University, Baltimore, MD, United States, 2Iowa State University, Ames, IA, United States, 3Kansas State University, Manhattan, KS, United States

478 484

EPIDEMIOLOGICAL INVESTIGATION OF ACUTE SPATIO-TEMPORAL PERSPECTIVES ON PREVALENCE CHAGAS DISEASE IN THE PERUVIAN AMAZON OF TRYPANOSOMA CRUZI INFECTION IN PERI-URBAN Cesar J. Ramal Asayag1, Rufi no Cabrera Champe2 AREQUIPA, PERU 1Loreto Regional Hospital, Punchana, Peru, 2Dirección General de Epidemiología, Lima, Stephen Delgado1, Ricardo Castillo Neyra2, Víctor R. Quispe Machaca2, Peru Jenny Ancca Juárez2, Manuela Verastegui2, César D. Bocángel2, Andrew Comrie1, César Náquira2, Juan G. Cornejo del Carpio3, Robert H. Gilman4, Caryn Bern5, Michael Z. Levy6 1University of Arizona, Tucson, AZ, United States, 2Universidad Peruana Cayetano Heredia, Lima, Peru, 3Dirección Regional del Ministerio de Salud, Arequipa, Peru, 4Johns Hopkins University, Baltimore, MD, United States, 5Centers for Disease Control and Prevention, Atlanta, GA, United States, 6Fogarty International Center, Bethesda, MD, United States

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PREDICTIVE FACTORS FOR UNFAVORABLE EXPRESSION PROFILING USING LEISHMANIA DONOVANI OUTCOMES IN THE TREATMENT OF HUMAN AFRICAN GENOMIC MICROARRAY FOR THE IDENTIFICATION TRYPANOSOMIASIS OF NOVEL VACCINE TARGETS FOR VISCERAL Mbiyangandu L. Kazumba1, Madishala P. Mulumba1, Desire D. Tshala- LEISHMANIASIS Katumbay2 Paresh Sharma1, Srividya Gurumurthy1, Robert Duncan2, Hira L. Nakhasi2, 1Kinshasa University, Kinshasa, The Democratic Republic of the Congo, 2Oregon Health Poonam Salotra1 and Sciences University, Portland, OR, United States 1Institute of Pathology (ICMR), New Delhi, India, 2Division of Emerging and Transfusion Transmitted Diseases, Bethesda, MD, United States 487 (ACMCIP Abstract)

EXPANDING BELT OF HUMAN AFRICAN 492 TRYPANOSOMIASIS (SLEEPING SICKNESS) IN PALLISA DISTRICT, UGANDA AN UNUSUAL HSP70 PRESENT IN RARE LEISHMANIA Loyce Okedi1, A. Patrick1, V. Alioni1, R. Azabo1, C. Sebikali1, M. Okitoi1, VIANNIA ISOLATES FROM PERU T. Amusugut2, M. Nalapa2, A. Mugyenyi3, A. Kakembo4, J. C. K Enyaru5, S. Nicolas Veland1, Rosa Pacheco2, Jorge Arevalo1 Aksoy6 1Universidad Peruana Cayetano Heredia, Lima, Peru, 2Universidad Nacional San 1National Livestock Resources Research Institute, Tororo, Uganda, 2Pallisa District Antonio Abad, Cusco, Peru Extension, Pallisa, Uganda, 3Coordinating Offi ce for Control of Trypanosomiasis in (ACMCIP Abstract) Uganda, MAAIF, Kampala, Uganda, 4National Sleeping Sickness Control Offi ce, Ministry of Health, Kampala, Uganda, 5Department of Biochemistry, Makerere 493 University, Kampala, Uganda, 6Yale School of Public Health, New Haven, CT, United States IDENTIFYING MICRORNAS THAT ALTER MACROPHAGE SUSCEPTIBILITY TO INFECTION BY LEISHMANIA KINETOPLASTIDA – MOLECULAR Joel W. Graff, Anne M. Dickson, Mary E. Wilson BIOLOGY AND IMMUNOLOGY University of Iowa, Iowa City, IA, United States (ACMCIP Abstract)

488 494

CHARACTERIZATION OF UNKNOWN GPI ANCHORED THE ANTIMICROBIAL PEPTIDES AARP-1 AND RP-1 PROTEINS IN TRYPANOSOMA BRUCEI BRUCEI DEMONSTRATE MICROBICIDAL ACTIVITY AGAINST Amy F. Savage, Serap Aksoy BOTH LEISHMANIA MAJOR AND LEISHMANIA CHAGASI Yale University, New Haven, CT, United States INFANTUM (ACMCIP Abstract) Consuelo Veronica G. David, Kevin Bruhn, Michael Yeaman, Noah Craft Los Angeles Biomedical Research Institute, Torrance, CA, United States 489 (ACMCIP Abstract)

MOLECULAR CHARACTERIZATION OF KINESINCAAX IN 495 TRYPANOSOMA BRUCEI

Erin J. Engelson COMPARATIVE PROTEOMIC ANALYSIS OF Friday, November 20 University of Washington, Seattle, WA, United States IMMUNODOMINANT 30-34 KDA PROTEINS OF (ACMCIP Abstract) TRYPANOSOMA CRUZI BY DIFFERENT MASS SPECTROMETRY METHODS 490 Giovani C. da Costa1, Leticia S. Lery1, Hercules Moura2, Vanda M. von Kruger1, Regina H. Peralta3, John R. Barr2, Jose M. Peralta1 LEISHMANIA INFANTUM ALDOSE REDUCTASE: 1Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 2Centers for Disease EXPRESSION WITH MOLECULAR CHAPERONES, Control, Atlanta, GA, United States, 3Universidade Federal Fluminense, Niteroi, Brazil PURIFICATION AND KINETIC STUDIES (ACMCIP Abstract) Lídia Barata1, Marta Sousa Silva1, Gonçalo da Costa1, Linda Schuldt2, António E. Ferreira1, Ana M. Tomás3, Manfred S. Weiss2, Ana Ponces Freire1, 496 Carlos Cordeiro1 1Faculdade de Ciencias da Universidade de Lisboa, Lisboa, Portugal, 2European TRYPANOSOMA CRUZI -INDUCED INFLAMMATION IN Molecular Biology Laboratory (EMBL), Hamburg, Germany, 3Instituto de Biologia ADIPOSE TISSUE Molecular e Celular (IBMC), Porto, Portugal FNU Nagajyothi1, Mahalia S. Desruisseaux1, Louis M. Weiss1, Philipp E. Scherer2, Herbert B. Tanowitz1 1Albert Einstein College of Medicine, Bronx, NY, United States, 2University of Texas S.W., Dallas, TX, United States (ACMCIP Abstract)

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497 503

EVALUATION OF INHIBITORY EFFECT OF A MALARIA DISCIPLINE: A COMPARATIVE STUDY OF TRYPANOSOMA BRUCEI CALCIUM CHANNEL ANTIBODY AMERICAN AND AUSTRALIAN TROOPS IN SOUTHEAST (ANTI-TBCC1) IN VITRO ASIA, 1967-1968 Kiantra I. Ramey1, Zuzana Kucerova2, Winston Thompson1, Jonathan K. David Adams, Laura F. Peaty Stiles1 AASU, Savannah, GA, United States 1Morehouse School of Medicine, Atlanta, GA, United States, 2Centers for Disease Control and Prevention, Atlanta, GA, United States 504 (ACMCIP Abstract) RANDOMIZED, PROSPECTIVE, THREE-ARM STUDY 498 OF THE AUDITORY FUNCTION FOLLOWING ANTIMALARIAL TREATMENT IN PATIENTS WITH DETECTION OF TRYPANOSOMA CRUZI ANTIGEN UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA IN SKELETAL MUSCLE OF FETUSES WITH 1 2 1 2 MORPHOLOGICAL STRUCTURAL ANOMALIES FROM Gabriel Carrasquilla , Mailis Virtanen , Clemencia Barón , Verena Walter , Laurel Fisher3, Anne-Claire Marrast2 MICE WITH ACUTE CHAGASIC INFECTION 1Fundación Santa Fe de Bogotá, Bogotá, Colombia, 2Novartis, Basel, Switzerland, 3House Maritza E. Alarcon, Mary C. Perez, Loredana Goncalves, Ana Lugo-Yarbuh, Ear Institute (HEI), Los Angeles, CA, United States Elio A. Moreno Universidad de los Andes, Merida, Venezuela 505 (ACMCIP Abstract) COHORT STUDY IN ZAMBIA EVALUATING THE SAFETY 499 OF ARTEMETHER-LUMEFANTRINE (AL; COARTEM®) AND SULFADOXINE-PYRIMETHAMINE (SP) IN CHARACTERIZATION AND EXPRESSION OF A NOVEL PREGNANT WOMEN WITH SYMPTOMATIC MALARIA SECRETORY NUCLEASE, LMEXNUCS, IN THE HUMAN 1 2 3 4 PATHOGEN LEISHMANIA MEXICANA Christine Manyando , Rhoda Mkandawire , Lwipa Puma , Moses Sinkala , Evans Mpabalwani5, Eric Njunju1, Melba Gomes6, Verena Walter7, Raymond Yunuen Hernandez, Courtney Kiphart, Manju B. Joshi, Dennis M. Dwyer Schlienger7, Mailis Virtanen7, Frank Sullivan8 National Institute of Allergy and Infectious Disease, Bethesda, MD, United States 1Tropical Diseases Research Centre, Ndola, Zambia, 2District Health Offi ce, Choma, Zambia, 3District Health Offi ce, Ndola, Zambia, 4District Health Offi ce, Lusaka, 500 Zambia, 5Department of Pediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia, 6World Health Organization, Geneva, Switzerland, 7Novartis Pharma IMPACT OF COMBINED TREATMENT OF ALLOPURINOL AG, Basel, Switzerland, 8Consultants in Toxicology, Brighton, United Kingdom AND BENZNIDAZOLE ON TOTAL AND TRYPANOSOMA 506 CRUZI-SPECIFIC T CELLS IN HUMAN CHRONIC CHAGAS DISEASE PHARMACOVIGILANCE OF INTERMITTENT 1 2 3 Damián Pérez-Mazliah , Rodolfo J. Viotti , Gretchen Colley , María G. PREVENTIVE TREATMENT IN INFANTS WITH Alvarez2, María C. Albareda1, Bruno Lococo2, Graciela Bertocchi2, Carlos A. Vigliano2, Alejandro H. Armenti2, Rick L. Tarleton3, Susana A. Laucella1 SULFADOXINE-PYRIMETHAMINE 1Instituto Nacional de Parasitología Dr. Mario Fatala Chabén, Buenos Aires, Argentina, Alexandra De Sousa 2Hospital Interzonal General de Agudos Eva Perón, Buenos Aires, Argentina, 3Center UNICEF, New York, NY, United States for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, United States 507 (ACMCIP Abstract) GENERATION AND CHARACTERIZATION OF A 5K MALARIA - CHEMOTHERAPY ANTIMALARIAL COMPOUND COLLECTION Kelli L. Kuhen1, Kerstin Gagaring1, Rachel Borboa1, Carolyn Francek1, 1 1 1 1 501 Zhong Chen , David M. Plouffe , Frantisek Supek , Lai Yin , Thierry Diagana2, Jennifer Taylor1, Arnab K. Chatterjee1, Richard J. Glynne1 1Genomics Institute of the Novartis Research Foundation, San Diego, CA, United States, ANTIMALARIAL DRUG DISPENSING AMONG 2Novartis Institute for Tropical Diseases, Singapore, Singapore COMMUNITY DRUG PROVIDERS IN IBADAN NIGERIA: A CROSS-SECTIONAL SURVEY 508 Catherine O. Falade1, Okezie O. Enwere2, Olusegun G. Ademowo1 1University of Ibadan, Ibadan Nigeria, 2Imo State University Teaching Hospital, Orlu, PHARMACOKINETICS OF CHLOROQUINE IN A MURINE Imo State, Nigeria MALARIA MODEL Kevin T. Batty1, Brioni R. Moore1, Madhu Page-Sharp1, Jillian Stoney1, 502 Jeffrey D. Jago1, Kenneth F. Ilett2 1Curtin University, Perth, Australia, 2University of WA, Perth, Australia FTY720 TREATMENT DURING EXPERIMENTAL MALARIA: POTENTIAL ADJUNCTIVE THERAPY FOR CEREBRAL MALARIA? Constance A. Finney, W. Conrad Liles, Kevin C. Kain University of Toronto, Toronto, ON, Canada (ACMCIP Abstract)

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A STUDY OF INTERMITTENT PREVENTIVE TREATMENT MONOQUINOLINE ANALOGUES HIGHLY ACTIVE AND HOME BASED MANAGEMENT OF MALARIA IN A AGAINST THE BLOOD STAGES OF PLASMODIUM IN VIVO RURAL AREA OF THE GAMBIA AND IN VITRO Kalifa A. Bojang1, Sanie Sesay1, Maimuna Sowe1, David Conway1, Paul Fabian E. Saenz1, Tina Mutka1, Ayo Oduola2, Dennis E. Kyle1 Milligan2, Brian Greenwood2 1University of South Florida, Tampa, FL, United States, 2UNICEF/UNDP/World 1MRC Laboratories, Banjul, Gambia, 2London School of Hygiene and Tropical Medicine, Bank/WHO Special Programme for Research and Training in Tropical Diseases London, United Kingdom (TDR), World Health Organization, Geneva, Switzerland

510 516

A TWO-GENERATION STUDY OF THE REPRODUCTIVE ANTI-PLASMODIUM ACTIVITY OF IMIDAZOLIUM AND TOXICITY OF PIPERAQUINE IN MICE TRIAZOLIUM SALTS Kevin T. Batty1, Brioni R. Moore1, Verity Stirling2, Kenneth F. Ilett2, Madhu Walter A. Szarek1, Ian E. Crandall2, Jason Z. Vlahakis1, Carmen Lazar1, Page-Sharp1, Keith B. Shilkin2, Ivo Mueller3, Stephen J. Rogerson4, Harin A. Simona Mitu1 Karunajeewa2, Timothy M. Davis2 1Queen’s University, Kingston, ON, Canada, 2University of Toronto/UHN, Toronto, ON, 1Curtin University, Perth, Australia, 2University of WA, Perth, Australia, 3PNG Canada Institute of Medical Research, Goroka, Papua New Guinea, 4University of Melbourne, Melbourne, Australia 517

MALARIA – DRUG DEVELOPMENT SAFETY OF PYRONARIDINE/ARTESUNATE IN CLINICAL TRIALS IN PATIENTS WITH UNCOMPLICATED ACUTE PLASMODIUM FALCIPARUM OR PLASMODIUM VIVAX 511 MALARIA: RESULTS OF AN INTEGRATED ANALYSIS

1 1 2 PHYSIOLOGICAL HIGH THROUGHPUT β-HEMATIN Stephan Duparc , Isabelle Borghini-Fuhrer , J. Carl Craft , Sarah Arbe- Barnes3, Robert M. Miller3, Chang-Sik Shin4, Lawrence Fleckenstein5 GROWTH ASSAY 1Medicines for Malaria Venture, Geneva, Switzerland, 2Former Medicines for Malaria John N. Alumasa, Katherine B. Nickley, Paul D. Roepe Venture, Geneva, Switzerland, 3Fulcrum Pharma Developments Ltd, Hemel Hempstead, Georgetown University, Washington, DC, United States United Kingdom, 4Shin Poong Pharmaceuticals, Seoul, Republic of Korea, 5University of (ACMCIP Abstract) Iowa, Iowa City, IA, United States

512 518

ABSOLUTE BIOAVAILABILITY OF CIS-MIRINCAMYCIN SYNTHESIS AND STRUCTURE-ACTIVITY AND TRANS-MIRINCAMYCIN IN HEALTHY RHESUS RELATIONSHIPS OF GENZ-644442 ANALOGS: A NOVEL MONKEYS, AND EX-VIVO ANTIMALARIAL ACTIVITY CHEMOTYPE WITH POTENT ACTIVITY PLASMODIUM AGAINST PLASMODIUM FALCIPARUM FALCIPARUM AND P. BERGHEI David Saunders1, Phisit Khemawoot1, Maneerat Rasameesoraj1, Victor Robert H. Barker, Jr. Melendez2, Rawiwan Imerbsin1, Colin Ohrt2, Susan Fracisco2, Paktiya Teja- Genzyme Corporation, Waltham, MA, United States isavadharm1 1Armed Forces Research Institute of the Medical Sciences, Bangkok, Thailand, 2Walter 519 Friday, November 20 Reed Army Institute of Research, Silver Spring, MD, United States A DUAL-SPECIFICITY PHOSPHOTYROSINE 513 PHOSPHATASE OF PLASMODIUM FALCIPARUM AND ITS POTENTIAL AS A NOVEL ANTIMALARIAL DRUG TARGET INDUSTRIAL CHICORY AS PRODUCTION PLATFORM FOR ARTEMISININ Christopher O. Campbell, Bharath Balu, Steven P. Maher, Roman Manetsch, John H. Adams 1 1 1 2 Teun van Herpen , Harro Bouwmeester , Jules Beekwilder , Herwig Jansen University of South Florida, Tampa, FL, United States 1Wageningen University, Wageningen, The Netherlands, 2Dafra Pharma international, Turnhout, Belgium 520 514 INHIBITORS OF FABI AS POTENTIAL ANTIMALARIAL PROPHYLACTIC AGENTS TETRAZOLIUM VIOLET INHIBITS MEROZOITE 1 1 1 1 INVASION Santha Kumar , Marcus Pereira , Lisa Purcell , Andrea Ecker , Photini Sinnis2, Julia Castro3, Alfonso Mendoza3, Jose Garcia-Bustos3, David Fidock1 1 2 Ian E. Crandall , Walter A. Szarek 1Columbia University Medical Center, New York, NY, United States, 2New York 1 2 University of Toronto, Toronto, ON, Canada, Queen’s University, Kingston, ON, University School of Medicine, New York, NY, United States, 3Diseases of Developing Canada World, GlaxoSmithKline, Tres Cantos, Spain

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THE USE OF TRANSGENIC PLASMODIUM FALCIPARUM INVESTIGATION OF GENETIC MUTATIONS IN IN THE EVALUATION OF IN VITRO ANTIPLASMODIAL PLASMODIUM VIVAX DIHYDROFOLATE REDUCTASE ACTIVITY OF ANTIMALARIAL DRUGS AND AND SUSCEPTIBILITY TO CONVENTIONAL AND NEW METHOTREXATE ANTIFOLATE ANTIMALARIALS USING A PLASMODIUM Olugbenga Akinola1, Olusola G. Gbotosho1, Christian T. Happi1, FALCIPARUM EXPRESSION SYSTEM Akin Sowunmi1, Mofolusho Falade1, Chairat Uthaipibull2, Sumalee Alyson M. Auliff1, Michael T. O’Neil2, Don L. Gardiner3, John H. Adams4, Kamchonwongpisan2, A.M. Oduola1 Qin Cheng1 1University of Ibadan, Ibadan, Nigeria, 2National Center for Genetic Engineering and 1Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Biotechnology, Pathum Thani, Thailand Enoggera, Australia, 2Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD, United States, 3Queensland Institute of Medical 522 Research, Brisbane, Australia, 4Global Health Infectious Disease Research Program, University of South Florida, Tampa, FL, United States A HIGH THROUGHPUT SCREEN TO IDENTIFY APICOPLAST-TARGETING ANTIMALARIALS 528 Eric Ekland1, Jessica Schneider1, Rebecca Muhle2, David Fidock1 1Columbia University Medical Center, New York, NY, United States, 2Albert Einstein CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM College of Medicine, New York, NY, United States HAPLOTYPES FROM THE BRAZILIAN AMAZON Giselle M. Viana, Marinete M. Póvoa MALARIA – DRUG RESISTANCE Instituto Evandro Chagas, Ananindeua, Brazil 529 523 A PROBABLE CASE OF CHLOROQUINE-RESISTANT HYPOTHESES OF DRUG RESPONSE DYNAMICS PLASMODIUM VIVAX IN THE PERUVIAN AMAZON TO EXPLAIN RECRUDESCENCE IN ARTESUNATE Salomon Durand1, Meddly Santolalla1, Carola Salas1, Valeria Soberon1, RESISTANT PLASMODIUM FALCIPARUM MALARIA Carlos Alvares Antonio2, Carmen Montalvan2, Mariella Galves Montoya2, 3 3 1 Richard J. Maude1, Wirichada Pontavornponyo1, Debasheesh Das1, Poravuth Andrea McCollum , Michael D. Green , Carmen Lucas , Venkatachalam 3 1 4 Yu2, Rupam Tripura1, Kamolrat Silamut1, Sompob Saralamba1, Aung Pyae Udhayakumar , Paul C. Graf , David J. Bacon 1 2 Phyo3, Nicholas P. Day1, Arjen M. Dondorp1, Francois Nosten3, Duong Naval Medical Research Center Detachment, Lima, Peru, Regional Health Directorate, 3 Socheat2, Nicholas J. White1, Lisa J. White1 Loreto, Peru, Centers for Disease Control and Prevention, Atlanta, GA, United States, 4 1Wellcome Trust Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand, Navy Environmental and Preventative Medicine Unit-2, Norfolk, VA, United States 2The National Center for Parasitology Entomology and Malaria Control, Phnom Penh, (ACMCIP Abstract) Cambodia, 3Shoklo Malaria Research Unit, Mae Sot Tak, Thailand (ACMCIP Abstract) 530

524 “YEAST OPTIMIZED” P. FALCIPARUM CRT (PFCRT) AND MDR1 PROTEINS (PFMDR1): PURIFICATION, ANALYSIS OF CHLOROQUINE TRANSPORT BY RECONSTITUTION AND PUTATIVE DRUG BINDING PURIFIED, RECONSTITUTED PFCRT Perri G. Pleeter, Linda Amoah, Jacqueline Lekostaj, Paul Roepe Michelle F. Paguio, Jayakumar J. Natarajan, Christian Wolf, Paul D. Roepe Georgetown University, Washington, DC, United States Georgetown University, Washington, DC, United States (ACMCIP Abstract) (ACMCIP Abstract) 531 525 ASSOCIATION BETWEEN SNPS IN TRANSPORTER RESISTANCE TO CHLOROQUINE CYTOTOXICITY IS GENES AND IN VITRO REDUCED SUSCEPTIBILITY TO NOT THE SAME AS RESISTANCE TO CHLOROQUINE ARTEMISININ DERIVATIVES IN PATIENTS ISOLATES OF CYTOSTASIS PLASMODIUM FALCIPARUM Mynthia Cabrera, Paul D. Roepe Christian T. Happi1, Onikepe A. Folarin1, Olusola G. Gbotosho1, Akintunde Georgetown University, Washington, DC, United States Sowunmi1, Dyann F. Wirth2, Ayoade M. Oduola3 (ACMCIP Abstract) 1University of Ibadan, Ibadan, Nigeria, 2Harvard School of Public Health, Boston, MA, United States, 3Special Programme for Research and Training in Tropical Diseases 526 (WHO/TDR), Geneva, Switzerland (ACMCIP Abstract) EFFICACY OF NON-CONTROLLED INTERMITTENT PREVENTIVE TREATMENT (IPTP) VERSUS CONTROLLED IPTP IN PREGNANT (IPTP) WOMEN IN CÔTE D’IVOIRE Toure A. Offi anan1, Penali L. Kone1, Berenger AA Ako1, Jambou Ronan2, Moussa Kone3 1Pasteur Institute, Abidjan, Cote d’Ivoire, 2Pasteur Institute, Paris, France, 3Pharmacy Sciences, Abidjan, Cote d’Ivoire

132 ASTMH 58th Annual Meeting www.astmh.org

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LONG TERM PERSISTENCE OF PLASMODIUM FALCIPARUM CLONES AND POTENTIAL BIAS IN MEASUREMENT OF 537 DRUG EFFICACY IN LOW TRANSMISSION AREAS PLACENTAL MALARIA AS A PREDICTOR OF LOW BIRTH 1 1 1 2 Claribel Murillo , Diego F. Echeverry , Lyda Osorio , Sanjay Menon , WEIGHT AMONG HIV-INFECTED AND UNINFECTED Shalini Nair2, Tim Anderson2 1Centro Internacional de Entranamiento e Investigaciones Médicas (CIDEIM), Cali, WOMEN IN TORORO, UGANDA Colombia, 2Southwest Foundation for Biomedical Research, San Antonio, TX, United Patrick Michael Newman1, Humphrey Wanzira2, Jane Achan3, Moses States Kamya3, Diane Havlir1, Philip J. Rosenthal1, Sarah Waldman1, Grant Dorsey1, Deborah Cohan1, Tamara D. Clark1 533 1University of California, San Francisco, San Francisco, CA, United States, 2Infectious Diseases Research Collaboration, Kampala, Uganda, 3Makerere University, Kampala, CANDIDATE GENE STUDIES IN LOW TRANSMISSION Uganda AREAS: DO SNPS (N326D AND S334N) IN THE 538 PLASMODIUM FALCIPARUM CHLOROQUINE TRANSPORTER (PFCRT) UNDERLIE RESISTANCE TO MOTHER’S KNOWLEDGE OF MALARIA PREDICTS ITN AMODIAQUINE/DESETHYLAMODIAQUINE? USE AND FEVER TREATMENT IN CHILDREN UNDER Diego F. Echeverry1, Claribel Murillo1, Lyda Osorio1, Sanjay Menon2, FIVE YEARS-MALARIA INDICATOR SURVEY, ETHIOPIA, 2 2 Shalini Nair , Tim Anderson 2007 1Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia, 2Southwest Foundation for Biomedical Research, San Antonio, TX, United Jimee Hwang1, Patricia M. Graves2, Richard Reithinger3, Asefaw Getachew4, States Hana Bilak4, Estifanos Biru Shargie5, Jeremiah Ngondi6, Chris Lungu4, Aryc Mosher2, Teshome Gebre5, Adam Wolkon1, Eskindir Tenaw7, S. Patrick 534 Kachur1, Daddi Jima8 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2The Carter Center, Atlanta, GA, United States, 3United States Agency for International CHARACTERIZING ARTEMISININ INDUCED DORMANCY Development, Addis Ababa, Ethiopia, 4Malaria Control and Evaluation Partnership in IN PLASMODIUM FALCIPARUM AND ITS POTENTIAL Africa, PATH, Seattle, WA, United States, 5The Carter Center, Addis Ababa, Ethiopia, IMPACT ON TREATMENT EFFICACY 6University of Cambridge Department of Public Health and Primary Care, Cambridge, 7 8 Franka Teuscher1, Michelle Gatton2, Nanhua Chen3, Jennifer Peters3, Dennis United Kingdom, Central Statistics Agency, Addis Ababa, Ethiopia, Disease Prevention E. Kyle4, Qin Cheng3 and Control Department, Ministry of Health, Addis Ababa, Ethiopia 1Queensland Institute of Medical Research/Australian Army Malaria Institute, Brisbane, Australia, 2Queensland Institute of Medical Research, Brisbane, Australia, 3Australian 539 Army Malaria Institute, Brisbane, Australia, 4University of South Florida, Tampa, FL, United States COMPARATIVE ANALYSIS OF SEQUENCES OF THE RECEPTOR BINDING DOMAIN (F2 REGION) OF P. 535 FALCIPARUM EBA 175 DERIVED FROM CHILDREN WITH SEVERE, UNCOMPLICATED AND ASYMPTOMATIC ASSOCIATION BETWEEN P. FALCIPARUM ABC MALARIA IN THE KASSENA NANKANA DISTRICT OF TRANSPORTERS SNPS AND IN VIVO PARASITE GHANA CLEARANCE AFTER CHLOROQUINE TREATMENT IN Beverly Egyir1, Charles Brown1, Langbong Bimi2, Kwadwo Koram1, Michael

MALI Wilson1 Friday, November 20 Mamadou Wele 1Noguchi Memorial Institute for Medical Research, Accra, Ghana, 2University of Ghana, Malaria Research and Training Center, Bamako, Mali Department of Zoology, Legon-Accra, Accra, Ghana (ACMCIP Abstract) 540 536 HOLDING THE LINE: LESSONS FROM MAURITIUS RESISTANCE SELECTION APPROACH TO IDENTIFY AND FOR PREVENTING REINTRODUCTION OF MALARIA VALIDATE NOVEL DRUG TARGETS FOR ANTIMALARIAL TRANSMISSION DRUG DISCOVERY Shahina Aboobakar1, T. Ram Nundlall2, Ambicadutt Bheecarry3, Allison Amar Bir S. Sidhu1, Joseph Cortese1, Erin Tyndall1, Roger Wiegand1, Derek Tatarsky4, Devanand Moonasar5, Oliver Sabot4 Martyn2, Jon Clardy2, Dyann Wirth3, Ralph Mazitschek2, Nayoung Lee2 1Ministry of Health and Quality of Life, Port Louis, Mauritius, 2Communicable Disease 1The Broad Institute of MIT and Harvard, Cambridge, MA, United States, 2Department Control Unit, Ministry of Health and Quality of Life, Port Louis, Mauritius, 3Vector of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Biology and Control Division, Ministry of Health and Quality of Life, Port Louis, MA, United States, 3Department of Immunology and Infectious Diseases, Harvard School Mauritius, 4William J. Clinton Foundation, Boston, MA, United States, 5William J. of Public Health, Boston, MA, United States Clinton Foundation and Global Health Group, Pretoria, South Africa

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MALARIA INCIDENCE IN INFANTS IN BANCOUMANA, SUCCESSFUL INTRODUCTION OF ARTESUNATE AND MALI AMODIAQUINE IS NOT ENOUGH TO FIGHT Mahamadou S. Sissoko1, Mahamadoun H. Assadou1, Mamady Kone1, Beh MALARIA - RESULTS FROM AN ADHERENCE STUDY IN Kamate1, Ousmane Guindo1, Abdoulbaki Diallo1, Issaka Sagara1, Merapen A. SIERRA LEONE 1 1 2 3 3 Guindo , Renion Saye , Michael P. Fay , Alemush Imeru , Mark A. Pierce , 1 2 2 3 1 1 1 1 Sibylle Gerstl , Sophie Dunkley , Ahmed Mukhtar , Samuel Baker , Jacob Alassane Dicko , Aldiouma Guindo , Dapa A. Diallo , Ogobara Doumbo , 4 3 3 Maikere Louis H. Miller , Ruth D. Ellis 1Médecins Sans Frontières UK, London, United Kingdom, 2Médecins Sans Frontières 1 Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Bamako, Brussels, Bo, Sierra Leone, 3Ministry of Health and Sanitation, Freetown, Sierra Leone, 2 Malaria Research and Training Center, Bamako, Mali, Biostatistics Research Branch, 4Médecins Sans Frontières Brussels, Brussels, Belgium National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rockville, MD, United States, 3Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD, United 547 States MALARIA PREVALENCE IN TSUNAMI-AFFECTED 542 DISTRICTS OF ACEH, INDONESIA Sigrid Hahn1, David Muiruki2, Abiola Fasina1, Richard Allan2 THE RELATIONSHIP BETWEEN ANTI-MEROZOITE 1Mount Sinai School of Medicine, New York, NY, United States, 2The MENTOR ANTIBODIES AND PROTECTION FROM PLASMODIUM Initiative, Skipton, United Kingdom FALCIPARUM MALARIA: A SYSTEMATIC REVIEW AND META-ANALYSIS 548

1 1 2 1 Freya J. Fowkes , Jack S. Richards , Julie A. Simpson , James G. Beeson ESTIMATES OF MALARIA AT COMMUNITY LEVEL 1Walter and Eliza Hall Institute, Parkville, Australia, 2Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, THROUGH COMMUNITY OWNED RESOURCE PERSONS Australia (CORPS) STRATEGY BY EARLY DIAGNOSIS AND TREATMENT OF FEVER CASES IN NORTHEASTERN 543 TANZANIA A.S.M Rutta, F. Francis, B. Mmbando, S. Sembuche, E.K. Malecela, S. USING DRIED BLOOD SPOTS TO MONITOR CHANGES Johari, D. Ishengoma, M.M. Lemnge IN ANTIBODY LEVELS TO PLASMODIUM FALCIPARUM IN A National Institute for Medical Research, Tanga Medical Research Centre, United REGION OF DECLINING MALARIA TRANSMISSION Republic of Tanzania Tamaki Kobayashi1, Sandra Chishimba2, Philip Thuma2, Sungano Mharakurwa2, Nirbhay Kumar1, William J. Moss1 549 1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 2The Malaria Institute at Macha, Choma, Zambia MALARIA IN THE FIRST YEARS OF LIFE AT A TIME (ACMCIP Abstract) OF BEDNET USE AND ARTESUNATE COMBINATION 544 THERAPY IN THE KASSENA-NANKANA DISTRICT OF NORTHERN GHANA MALARIA AND HIV: RELATIVE RATES OF Kwadwo A. Koram1, David J. Fryauff2, Frank Atuguba3, Abraham 3 3 3 3 ASYMPTOMATIC FALCIPARUM GAMETOCYTEMIA AND HIV Hodgson , Thomas Anyorigiya , Victor Asoala , Martin Adjuik , Abraham R. Oduro3, Thomas L. Richie2, Francis Nkrumah1 CARRIAGE IN THE BLOOD DONOR POPULATION IN 1Noguchi Memorial Institute of Medical Research, Accra, Ghana, 2Naval Medical NYANZA PROVINCE, KENYA Research Center, Silver Spring, MD, United States, 3Navrongo Health Research Center, V. Ann Stewart1, Margaret Odour2, Laura Dickson1, Joseph Koros1, Navrongo, Ghana Nancy Nyakoe1, Elizabeth Anyonje2, Lucas Otieno1, Maria Bovill1, Angus Scrimgeour3, Bernards Ogutu1, Mark Polhemus4, John Waitumbi1, Shirley MALARIA - IMMUNOLOGY Luckhart5 1USAMRU-K, Kisumu, Kenya, 2Regional Blood Transfusion Centre, Kisumu, Kenya, 3USARIEM, Natick, MA, United States, 4Walter Reed Army Institute of Research, 550 Silver Spring, MD, United States, 5University of California, Davis, CA, United States MALARIA INFECTION IN INDIVIDUALS TAKING 545 MEFLOQUINE DOES NOT INDUCE ANTIBODY RESPONSE TO MSP142 COMPARING AND VALIDATING MATHEMATICAL MODELS OF MALARIA TRANSMISSION USING James Moon, Gregory Deye, Lori Miller, Susan Fracisco, R. Scott Miller, Donna Tosh, James Cummings, Colin Ohrt, Alan Magill BAYESIAN METHODS Walter Reed Army Institute of Research, Silver Spring, MD, United States Jamie T. Griffi n, Azra C. Ghani Imperial College, London, United Kingdom

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ANALYSES OF CD8+ T CELL IMMUNE RESPONSES INTERLEUKIN-23 RECEPTOR POLYMORPHISM (C/T) IS DURING THE PLASMODIUM YOELII BLOOD STAGE ASSOCIATED WITH PROTECTION AGAINST SEVERE INFECTION MALARIAL ANEMIA IN KENYAN CHILDREN Takeshi Ono, Atsuhiro Kanayama, Yoko Yamaguchi, Saori Umemoto, Jun John M. Ong’echa1, Samuel B. Anyona1, Collins Ouma1, Gregory C. Yamada, Koki Kaku, Yasushi Miyahira Davenport2, Tom Were1, Jeremy Martinson2, Robert E. Ferrell2, Douglas J. National Defense Medical College, Tokorozawa, Saitama, Japan Perkins3 (ACMCIP Abstract) 1University of New Mexico, Laboratories of Parasitic and Viral Diseases, Kisumu, Kenya, 2University of Pittsburgh, Pittsburgh, PA, United States, 3University of New 552 Mexico School of Medicine, Albuquerque, NM, United States (ACMCIP Abstract) ANTIBODY LEVELS TO AMA1 AND MSP142 IN MALIAN 557 INFANTS

1 2 2 Ruth D. Ellis , Mahamadou Sissoko , Mahamadoun H. Assadou , Merapen ASSOCIATION BETWEEN MIP-1ALPHA (MIP-1α) A. Guindo2, Renion Saye2, Mamady Kone2, Ousmane Kante2, Beh Kamate2, Ousmane Guindo2, Issaka Sagara2, Alassane Dicko2, Alemush Imeru1, PROMOTER HAPLOTYPES AND HIGH-DENSITY Michael P. Fay3, Mark Pierce1, Louis Miller1, Kazutoyo Miura1, Dapa Diallo2, PARASITEMIA IN CHILDREN FROM WESTERN KENYA Ogobara Doumbo2 Tom Were1, Gregory C. Davenport2, Collins Ouma1, Samuel B. Anyona1, 1Malaria Vaccine Development Branch, National Institute of Allergy and Infectious James B. Hittner3, John M. Vulule4, John M. Ong’echa1, Douglas J. Perkins5 Disease, National Institutes of Health, Rockville, MD, United States, 2Malaria Research 1University of New Mexico, Laboratories of Parasitic and Viral Diseases, Kisumu, and Training Center, Faculty of Medicine Pharmacy and Dentistry, University of Kenya, 2University of Pittsburgh, Pittsburgh, PA, United States, 3College of Charleston, Bamako, Bamako, Mali, 3Biostatistics Research Branch, National Institute of Allergy Charleston, SC, United States, 4Kenya Medical Research Institute, Kisumu, Kenya, and Infectious Disease, National Institutes of Health, Rockville, MD, United States 5University of New Mexico, School of Medicine, Albuquerque, NM, United States (ACMCIP Abstract) 553 558 DUFFY ANTIGEN RECEPTOR FOR CHEMOKINES INFLUENCES LEUKOCYTE POPULATIONS AND SEROPREVALENCE OF IGG ANTIBODIES TO CIRCULATING INFLAMMATORY MEDIATORS IN PLASMODIUM VIVAX MSP-1 ANTIGEN AND PLASMODIUM KENYAN CHILDREN WITH MALARIA AND HIV-1 FALCIPARUM GLURP R2 ANTIGEN IN THE AMAZON AREA, Gregory C. Davenport1, Samuel B. Anyona2, Collins Ouma2, Tom Were2, IQUITOS-PERU James B. Hittner3, John M. Ong’echa2, Douglas J. Perkins4 Katherine Torres1, Elizabeth Villasis1, Jorge Bendezu1, Annette Erhart2, 1University of Pittsburgh, Pittsburgh, PA, United States, 2University of New Mexico/ Umberto D’Alessandro2, Dionicia Gamboa1 KEMRI, Kisumu, Kenya, 3College of Charleston, Charleston, SC, United States, 1Instituto de Medicina Tropical “Alexander von Humboldt”, Universidad Peruana 4University of New Mexico, Albuquerque, NM, United States Cayetano Heredia, Lima, Peru, 2Institute of Tropical Medicine “Prince Leopold”, (ACMCIP Abstract) Antwerp, Belgium (ACMCIP Abstract) 554 559 EVALUATION OF CYTOKINE LEVELS AND DISEASE SEVERITY IN PLASMODIUM FALCIPARUM MALARIA P. FALCIPARUM MEROZOITE SURFACE PROTEIN 6:

PATIENTS FROM THE PERUVIAN AMAZON BASIN GENETIC DIVERSITY AND ANTIBODY RESPONSES IN Friday, November 20 Laura L. Tapia1, Stella M. Chenet2, Carmen M. Lucas1, Richard S. Witzig3, A LONGITUDINAL COHORT STUDY IN THE PERUVIAN Paul C. Graf1, David J. Bacon4 AMAZON 1 2 Naval Medical Research Center Detachment, Lima, Peru, Arizona State University, 1 1 1 2 3 Ana L. Oliveira , Stephen J. Jordan , Aaron T. Neal , Oralee H. Branch , Tempe, AZ, United States, Tulane University Medical School, New Orleans, LA, United 3 4 Julian C. Rayner States, Navy Environmental and Preventive Medicine Unit-2, Norfolk, VA, United 1University of Alabama at Birmingham, Birmingham, AL, United States, 2New States York University, New York, NY, United States, 3Wellcome Trust Sanger Institute, (ACMCIP Abstract) Cambridge, United Kingdom (ACMCIP Abstract) 555

A VARIANT WITHIN THE STEM CELL GROWTH FACTOR MALARIA - VACCINES (SCGF) PROMOTER (-539C/T) IS ASSOCIATED WITH PROTECTION AGAINST PEDIATRIC SEVERE MALARIAL 560 ANEMIA AND FUNCTIONAL CHANGES IN CIRCULATING SCGF A NOVEL APPROACH TO DESIGN MULTICOMPONENT Collins Ouma1, Gregory C. Davenport2, Tom Were1, Samuel B. Anyona1, BLOOD STAGE MALARIA VACCINES Henry O. Ndege1, James B. Hittner3, John M. Vulule4, Jeremy Martinson2, Demanga G. Corine1, Daher Lena Juliette1, Blanc Catherine1, Prieur Eric1, John M. Ong’echa1, Robert E. Ferrell2, Douglas J. Perkins5 Roussilhon Christian1, Pérignon Jean-Louis1, Mbacham Wilfred2, Pierre 1University of New Mexico Laboratories of Parasitic and Viral Diseases, Kisumu, Druilhe1 Kenya, 2University of Pittsburgh, Pittsburgh, PA, United States, 3College of Charleston, 1Pasteur Institute, Paris, France, 2Laboratory of Public Health, Biotechnology Centre, Charleston, SC, United States, 4Kenya Medical Research Institute, Kisumu, Kenya, Yaoundé, Cameroon 5University of New Mexico School of Medicine, Albuquerque, NM, United States (ACMCIP Abstract) (ACMCIP Abstract)

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STABILITY OF THE PLASMODIUM FALCIPARUM AMA1 ALLELE-SPECIFIC EFFICACY OF AN AMA-1-BASED VACCINE FORMULATED IN MONTANIDE ISA 720 MALARIA SUBUNIT VACCINE Daming Zhu, Mary Anne Kidwell, Holly McClellan, Weili Dai, Elizabeth Amed Ouattara1, Shannon Takala1, Drissa Coulibaly2, Niangaly Amadou2, Gebregeorgis, Louis Miller Renion Saye2, Mahamadou A. Thera2, Christopher V. Plowe1, Ogobara K. Malaria Vaccine Development Branch, Rockville, MD, United States Doumbo2 1CVD, Baltimore, MD, United States, 2DEAP/Malaria Research and Training Center, 562 Bamako, Mali (ACMCIP Abstract) IMMUNIZATION WITH N-TERMINAL REGION OF 567 A GAMETOCYTE PROTEIN PFS230 SUCCESSFULLY INDUCE TRANSMISSION-BLOCKING ANTIBODIES OPTIMAL TARGETS IN THE SPOROZOITE LIFECYCLE AGAINST PLASMODIUM FALCIPARUM FOR PRE-ERYTHROCYTIC MALARIA VACCINES Mayumi Tachibana1, Hideyuki Iriko2, Olga Muratova3, Guanhong Song3, Yimin Wu3, Jetsumon Sattabongkot4, Satoru Takeo5, Hitoshi Otsuki1, Motomi Michael T. White Torii1, Takafumi Tsuboi5 Imperial College London, London, United Kingdom 1Ehime University, Toon, Japan, 2Tottori University, Yonago, Japan, 3National Institute of Allergy and Infectious Diseases, Rockville, MD, United States, 4Armed Forces Research 568 Institute of Medical Sciences, Bangkok, Thailand, 5Ehime University, Matsuyama, Japan EVALUATION OF POTENTIAL MALARIA VACCINE ANTIGENS IN P. YOELII/MOUSE MODEL 563 Keith Limbach, Joao Aguiar, Kalpana Gowda, Noelle Patterson, Martha Sedegah, Steve Abot, Thomas Richie SHIFT IN EPITOPE DOMINANCE OF IGM AND IGG United States Military Malaria Vaccine Program, Silver Spring, MD, United States RESPONSES TO P. FALCIPARUM MSP1 BLOCK 4 (ACMCIP Abstract) Sandra P. Chang1, Alexander K. Kayatani1, Zilka I. Terrientes2, Socrates Herrera3, Rose G. Leke4, Diane W. Taylor1 569 1John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States, 2Faculty of Medicine, University of Panama, Panama City, Panama, 3Instituto COMBINATION OF SEROLOGICALLY DISTINCT de Immunologia, Universidad del Valle, Cali, Colombia, 4Faculty of Medicine and ADENOVIRAL VECTORS IN PRIME-BOOST SCHEDULE Biomedical Research, University of Yaounde, Yaounde, Cameroon FOR MALARIA VACCINATION (ACMCIP Abstract) Ariane Rodriguez1, Ratna Mintardjo1, Dennis Tax1, Gert Gillissen1, 564 Jerome Custer1, Maria G Pau1, Jaco Klap1, Sampa Santra2, Harikrishnan Balachandran2, Norman L Letvin2, Jaap Goudsmit1, Katarina Radoševic1 1Crucell Holland BV, Leiden, The Netherlands, 2Beth Israel Deaconess Medical Center, HOW WILL MALARIA EVOLVE IN RESPONSE TO A Harvard Medical School, Boston, MA, United States VACCINE? Victoria C. Barclay1, Brian H. Chan1, Robin F. Anders2, Andrew F. Read1 570 1Pennsylvania State University, State College, PA, United States, 2La Trobe University, Melbourne, Australia COMPARING PRIME-BOOST REGIMENS OF PLASMODIUM VIVAX CS PROTEIN, DNA AND ADENOVIRAL (AD5) 565 VACCINES FOR IMMUNOGENICITY IN MICE

1 1 1 2 PURIFIED IGGS WHICH ARE OBTAINED FROM MALIAN Tupur Husain , Thomas L. Richie , Keith Limbach , Joseph T. Bruder , Sofi a Casares1, Martha Sedegah1, Noelle Patterson1, Lisa Ware1, John Cargo1, CHILDREN AND WHICH DO NOT BIND TO APICAL Fouzia Farooq1, Christian F. Ockenhouse1, Anjali Yadava1 MEMBRANE ANTIGEN 1(AMA1) INTERFERE WITH THE 1United States Military Malaria Vaccine Program, Silver Spring, MD, United States, BIOLOGICAL ACTIVITY OF AMA1-SPECIFIC IGGS AS 2GenVec, Inc., Gaithersburg, MD, United States JUDGED BY THE IN VITRO GROWTH INHIBITION ASSAY Kazutoyo Miura1, Suwani Perera1, Sarah Brockley1, Hong Zhou2, Joan A. 571 Aebig1, Samuel E. Moretz2, Louis Miller1, Issaka Sagara3, Alassane Dicko3, Ruth D. Ellis1, Carole Long2 USE OF PRIME-BOOST COMBINATIONS OF 1Malaria Vaccine Development Branch/National Institute of Allergy and Infectious ATTENUATED SPOROZOITE AND SUBUNIT VACCINES Diseases/National Institutes of Health, Rockville, MD, United States, 2Laboratory of TO INDUCE POTENT PROTECTION AGAINST Malaria and Vector Research/National Institute of Allergy and Infectious Diseases/ SPOROZOITE CHALLENGE AND DEVELOP A National Institutes of Health, Rockville, MD, United States, 3Malaria Research and Training Center/Faculty of Medicine, Pharmacy and Dentistry/University of Bamako, SCREENING TOOL FOR PROTECTIVE NOVEL ANTIGENS Bamako, Mali Maria Belmonte, Stephen Abot, Glena Banania, Lennylynn Lejano, Renato Sayo, Harini Ganeshan, Dianne Litilit, Christian F. Ockenhouse, Thomas L. Richie, Martha Sedegah United States Military Malaria Vaccine Program, Silver Spring, MD, United States (ACMCIP Abstract)

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SITE CHARACTERIZATION FOR A MALARIA VACCINE LARVICIDAL AND ANTI-LA CROSSE VIRUS EFFECTS OF TRIAL IN THE SAPONÉ HEALTH DISTRICT IN BURKINA PLANT-DERIVED COMPOUNDS FASO: THE PREVALENCE OF PARASITES THAT MIGHT Nicole E. Eastep, Justin R. Anderson INTERFERE WITH THE ASSESSMENTS OF VACCINE Radford University, Radford, VA, United States SAFETY AND EFFICACY Ouedraogo Alphonse1, Tiono B. Alfred1, Ouedraogo Esperance1, Yaro 578 B. Jean Baptiste1, Kabore Youssouf1, Kargougou W. Desire1, Kangoye T. David1, Bougouma C . Edith1, Diarra Amidou1, Soulama Issiaka1, Sanon INSECTICIDE TREATED CAMOUFLAGE SCREENING Souleymane1, Gansane Adama1, Konate T. Amadou1, Nebie Issa1, Sirima B. REDUCES SAND FLY NUMBERS IN LEISHMANIA- Sodiomon2 ENDEMIC REGIONS IN KENYA 1Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina 1 1 1 Faso, 2Centre National de Recherche et de formation sur le Paludisme, Groupe de Kenneth J. Linthicum , Seth C. Britch , Willard W. Wynn , Jeffrey W. 2 2 2 2 3 Recherche et d’Action en Santé, Ouagadougou, Burkina Faso Clark , Daniel Ng’nonga , Francis Ngere , Clifford Kibet , Todd W. Walker , Muhammad Farooq3, Cathy A. Robinson3, Vincent L. Smith3, James C. Dunford3, Assaf Anyamba4 MOSQUITOES – INSECTICIDE 1USDA-ARS, Center for Medical, Agricultural and Veterinary Entomology, Gainesville, RESISTANCE AND CONTROL FL, United States, 2United States Army Medical Research Unit - Kenya, Kisumu, Kenya, 3United States Navy Entomology Center of Excellence, Jacksonville, FL, United States, 4NASA - Goddard Space Flight Center, Greenbelt, MD, United States 573 579 SEASONAL VARIATION IN SPECIES COMPOSITION AND FREQUENCY OF INSECTICIDE RESISTANCE ALLELES HOW TO MAKE EVOLUTION-PROOF INSECTICIDES FOR (KDR AND ACE-1R) IN THE ANOPHELES GAMBIAE MALARIA CONTROL COMPLEX FROM AN IRRIGATED RICE FIELDS AREA IN Andrew F. Read1, Penelope A. Lynch2, Matthew B. Thomas1 1 2 WESTERN BURKINA FASO Pennsylvania State University, University Park, PA, United States, Open University, Milton Park, United Kingdom Moussa Namountougou1, Frédéric Simard2, Kobié Hyacinthe Toe1, Simon P. 1 1 1 3 Sawadogo , Abdoulaye Diabate , Jean Bosco Ouedraogo , Thierry Baldet , 580 Roch Dabire1 1IRSS, Bobo-Dioulasso, Burkina Faso, 2IRSS/IRD, Bobo-Dioulasso, Burkina Faso, 3IRD/CIRAD, Cotonou, Benin GENETIC CONTROL OF AEDES ALBOPICTUS USING THE RIDL® SYSTEM 574 Geneviève Labbé1, Guoliang Fu2, Derric Nimmo2, Luke Alphey2 1Imperial College, London, United Kingdom, 2Oxitec Limited, Oxford, United Kingdom INFLUENCE OF INSECTICIDES RESISTANCE ON THE SALIVARY PROTEINS OF CULEX PIPIENS 581 QUINQUEFASCIATUS MOSQUITO Innocent Djegbe BEHAVIORAL RESPONSE OF CULEX QUINQUEFASCIATUS TM CREC/IRD, Cotonou, Benin TO DUET INSECTICIDE Gary G. Clark1, Sandra A. Allan1, Miriam F. Cooperband2, William Jany3 1 575 Center for Medical, Agricultural and Veterinary Entomology, United States Department Friday, November 20 of Agriculture, Gainesville, FL, United States, 2Center for Plant Health Science VARIABILITY IN MOSQUITO RESPONSE TO Technology, United States Department of Agriculture, Otis Air National Guard Base, MA, United States, 3Clarke Mosquito Control, Roselle, IL, United States COMMERCIAL REPELLENT FORMULATIONS TESTED IN THE FOREST AREA OF CAMEROON 582 Philippe B. Nwane1, Josiane Etang1, Carlo Costantini2, Francis Batomen3, 1 4 5 Christophe Antonio-Nkondjio , Rémy Mimpfoundi , Frédéric Simard PYRETHROID RESISTANCE AND THE COMPLEXITY OF 1OCEAC, Yaounde, Cameroon, 2IRD, Yaounde, Cameroon, 3DNS, Yaoundé, Yaounde, Cameroon, 4University of Yaoundé I, Yaounde, Cameroon, 5IRD, Burkina Faso, Burkina TESTING INNOVATIVE PRODUCTS Faso Helen V. Jamet, Tessa Knox, Georgina Victoria Bingham, Michael Stanley Pedersen 576 Vestergaard Frandsen, Lausanne, Switzerland

A NOVEL DISSEMINATION TOOL FOR THE 583 APPLICATION OF MOSQUITO LARVICIDES DEVELOPMENT OF A BIOSENSOR CHIP FOR SNP Gregor J. Devine1, Elvira Zamora Perea2, Daniel Lenin del Cuadro Hidalgo2, Nicole Achee3 GENOTYPING IN THE VOLTAGE GATED SODIUM 1Rothamsted Research, Harpenden, United Kingdom, 2Laboratorio de Salud Publica, CHANNEL GENE OF AEDES AEGYPTI (DIPTERA: Iquitos, Peru, 3Uniformed Services University of the Health Sciences, Bethesda, MD, CULICIDAE) United States Guadalupe C. Reyes-Solis1, Joshua Klonoski2, Rob Jenison2, Karla L. Saavedra-Rodríguez1, William C. Black IV1 1Colorado State University, Fort Collins, CO, United States, 2Great Basin Scientifi c, Longmont, CO, United States

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EVALUATION OF THE LARVICIDE PYRIPROXYFEN BIOACOUSTICS AND COURTSHIP IN AEDES AEGYPTI (SUMILARV 0,5 G) AGAINST AEDES AEGYPTI (DIPTERA: AND ANOPHELES GAMBIAE CULICIDAE) RESISTANCE TO TEMEPHOS AND Lauren J. Cator, Ronald R. Hoy, Laura C. Harrington DELTAMETHRIN Cornell University, Ithaca, NY, United States Milagros J. Oviedo1, Jorge L. Suarez1, Laura C. Vasquez1, Leslie C. Alvarez1, Gianna Martiradonna2, Darjaniva Molina2 591 1Universidad de Los Andes, Trujillo, Venezuela, 2Instituto de Altos Estudios en Salud Pública Dr. Arnoldo Gabaldón, Maracay, Venezuela INNATE HOST SELECTION BY CULEX PIPIENS SAY (DIPTERA: CULICIDAE) 585 Jennifer E. Simpson1, Corrine M. Folsom1, James E. Childs1, Leah E. Simmons2, Theodore G. Andreadis3, Maria A. Diuk-Wasser1 DETERMINANTS OF FOCAL INSECTICIDE RESISTANCE 1Yale University, New Haven, CT, United States, 2Stony Brook University, Stony Brook, OF AEDES AEGYPTI IN THE PHILIPPINES NY, United States, 3The Connecticut Agricultural Experiment Station, New Haven, CT, Frank Mannix1, Cecille Lopez2, Manuel Mapue3, Lyndon Leesoy4, Dawn United States Wesson1 1Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 592 United States, 2Tarlac Provincial Health Offi ce, Tarlac City, Philippines, 3Valenzuela City Health Offi ce, Valenzuela City, Philippines, 4Department of Health, Manila, ASSESSING RISK IN FOCAL ARBOVIRAL INFECTIONS: Philippines ARE WE MISSING THE BIG OR LITTLE PICTURE? Andrew D. Haddow1, Carl J. Jones2, Reid R. Gerhardt2, Agricola R. Odoi2 MOSQUITOES – VECTOR BIOLOGY- 1University of Texas Medical Branch, Galveston, TX, United States, 2University of EPIDEMIOLOGY Tennessee, Knoxville, TN, United States 593 586 EFFECTS OF DIFFERENTIAL ITN COVERAGE ON OVIPOSITION SITE SELECTION IN THE DENGUE MOSQUITO ABUNDANCE IN FOUR ECOLOGICAL VECTOR, AEDES AEGYPTI SETTINGS IN COASTAL KENYA Jacklyn Wong, Amy C. Morrison, Helvio Astete, Steven T. Stoddard, Francis Mutuku1, Charles H. King2, Peter L. Mungai3, Eric M. Muchiri3, Thomas W. Scott Edward D. Walker4, Uriel Kitron1 University of California, Davis, Davis, CA, United States 1Emory University, Atlanta, GA, United States, 2Case Western Reserve University, Cleveland, OH, United States, 3Division of Vector Borne and Neglected Diseases, Ministry 587 of Public Health and Sanitation, Kenya, 4Michigan State University, East Lansing, MI, United States IMPACT OF LARVAL MOSQUITO COMPETITION ON COMPONENTS OF VECTORIAL CAPACITY 594 Bruce H. Noden, Paul A. O’Neil, Joseph E. Fader, Steven A. Juliano COMBINING ENVIRONMENTAL MANAGEMENT WITH Illinois State University, Normal, IL, United States INSECTICIDE-TREATED NETS FOR MALARIA CONTROL 588 Laith Yakob, Guiyun Yan University of California, Irvine, Irvine, CA, United States LONGEVITY OF ANOPHELES GAMBIAE S.L. UNDER NATURAL CONDITIONS USING A MODIFIED MARK 595 RELEASE RECAPTURE APPROACH IMMUNOLOGICAL PRIMING IN AN. GAMBIAE: CAN Tovi Lehmann1, Adamou Alpha2, Moussa Diallo2, Alpha S. Yaro2, Yaya MOSQUITOES ‘LEARN’ FROM A CHALLENGE WITH Kassogue2, Adama Dao2 1National Institute of Allergy and Infectious Diseases/National Institutes of Health, PLASMODIUM? Rockville, MD, United States, 2Malaria Research and Training Center, University of Janneth Rodrigues, Rajnikant Dixit, Corrie Ortega, Alvaro Molina-Cruz, Mali, Bamako, Mali Carolina Barillas Mury National Institute of Allergy and Infectious Diseases, National Institutes of Health, 589 Rockville, MD, United States (ACMCIP Abstract) SPATIAL CLUSTERING OF WEST NILE VIRUS INFECTION IS ASSOCIATED WITH COMBINED SEWER 596 OVERFLOW CREEKS IN URBAN ATLANTA, GEORGIA MOSQUITOES AND DENGUE VIRUSES IN SCHOOLS IN Gonzalo M. Vazquez-Prokopec1, Jodi Vanden Eng2, Rosmarie Kelly3, Daniel MÉRIDA, MEXICO Mead4, Priti Kolhe5, Luis F. Chaves1, Thomas Burkot2, Uriel Kitron1 1Emory University, Atlanta, GA, United States, 2Centers for Disease Control and Jose Arturo Farfan-Ale1, Julián García-Rejón1, María Alba Loroño-Pino1, Prevention, Atlanta, GA, United States, 3Georgia Division of Public Health, Atlanta, Guadalupe Nuñez-Ayala2, Lars Eisen3, Barry J. Beaty3 GA, United States, 4University of Georgia, Athens, GA, United States, 5Fulton County 1Universidad Autónoma de Yucatán, Merida, Mexico, 2Secretaría de Salud de Yucatán, Department of Health and Wellness, Atlanta, GA, United States Merida, Mexico, 3Colorado State University, Fort Collins, CO, United States

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597 BACTERIOLOGY – OTHER BACTERIAL INFECTIONS MONITOR AND OPTIMIZE DURABLY THE USAGE OF INSECTICIDE TREATED NETS WITHIN HOUSEHOLDS WITH DETECTOR FOR REDUCING MALARIA 603 TRANSMISSION, IN CENTRAL IVORY COAST: RESULTS OF PRELIMINARY TRIALS A COMPARATIVE CLINICAL STUDY OF INVASIVE PNEUMOCOCCAL DISEASE CAUSED BY PENICILLIN- Guibehi B. Koudou, Janet Hemingway Liverpool School of Tropical Medicine, Liverpool, United Kingdom RESISTANT AND PENICILLIN-SENSITIVE STREPTOCOCCUS PNEUMONIAE IN THAILAND 598 Natawan Siripongpreeda King Chulalongkorn Memorial Hospital, Bangkok, Thailand MALARIA TRANSMISSION ALONG THE NIGER RIVER IN A SUDAN SAVANNA AREA OF MALI 604 Nafomon Sogoba1, Moussa Keita1, Mahamadou Diakite1, M’Bouye Diallo1, Ibrahima Baber1, Nicholas C. Manoukis2, Sekou F. Traore1, Seydou IDENTIFICATION AND COMPARISON OF Doumbia1, Jose M. Ribeiro2 MYCOBACTERIUM LEPRAE GENOTYPES IN TWO 1Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Odonto- DIFFERENT GEOGRAPHICAL REGIONS OF COLOMBIA stomatology, University of Bamako, Bamako, Mali, 2Laboratory of Malaria and Vector Nora M. Cardona-Castro1, Camilo Beltrán-Alzate1, Marcela Romero- Research, National Institute of Allergy and Infectious Diseases, National Institutes of Montoya1, Esperanza Melendez2, Fernando Torres3, Rama Murthy Sakamuri4, Health, Rockville, MD, United States Wei Li4, Varalakshmi Vissa4 1Instituto Colombiano de Medicina Tropical - Universidad CES, Sabaneta, Antioquia, 599 Colombia, 2E.S.E. Hospital General de Barranquilla, Barranquilla, Atlántico, Colombia, 3Sanatorio de Agua de Dios, Agua de Dios, Cundinamarca, Colombia, 4Department of SPATIAL VARIATION OF HOST SELECTION IN CULEX Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, PIPIENS MOSQUITOES United States Gabriel Hamer1, Tony Goldberg1, Uriel Kitron2, Jeffrey Brawn3, Scott Loss4, Marilyn Ruiz3, Edward Walker5 605 1University of Wisconsin, Madison, WI, United States, 2Emory University, Atlanta, GA, United States, 3University of Illinois, Champaign, IL, United States, 4University of TUBERCULOSIS RELATED STIGMA EPIDEMIOLOGY Minnesota, St. Paul, MN, United States, 5Michigan State University, East Lansing, MI, AND RISK FACTORS United States Colleen Acosta1, Alejandro Necochea2, Matthew Baldwin1, Rosario Montoya3, Dami Onifade4, Carolyn M. Ford1, Robert H. Gilman2, Carlton A. Evans5 600 1Asociación Benéfi ca PRISMA, Lima, Peru, 2Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 3Universidad Peruana Cayetano Heredia, Lima, BEHAVIORAL CHANGES OF FEMALE AEDES AEGYPTI IN Peru, 4Innovation For Health and Development, London, United Kingdom, 5Wellcome RESPONSE TO VARIOUS COMBINATIONS OF MATERIAL Centre for Clinical Tropical Medicine and Department of Infectious Diseases and TEXTURES, COVERAGE, AND DOSES OF INSECTICIDES Immunity, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom USING A NOVEL LABORATORY ASSAY Hortance Manda, Luana Arce, Victoria Hardy, Tarra Foggie, John Grieco, 606 Nicole Achee Uniformed Services University of the Health Sciences, Bethesda, MD, United States THE IMPLICATIONS OF 17,000 FIRST-LINE AND 11,800 Friday, November 20 601 SECOND-LINE DRUG SUSCEPTIBILITY TESTS FOR SELECTING OPTIMAL TB TREATMENT IMMUNOGENICITY OF ANOPHELES ALBIMANUS SALIVA Alberto Mendoza, Neyda Quispe, Elena Leo, George Obregon, Juan IN MALARIA ENDEMIC AND NON-ENDEMIC AREAS Ramirez, Eddy Valencia, Lucy Vasquez, Margoth Acurio, Luis Asencios National Institute of Health, Lima, Peru Berlin L. Londono1, Daisy Carvajal2, Diva Palacios3, Adam Bennett1, Lina 1 1 1 1 1 Moses , Joseph Keating , Thomas Eisele , Mark James , Don Krogstad , 607 Dawn Wesson1 1Tulane University, New Orleans, LA, United States, 2Universidad de Pamplona, Pamplona, Colombia, 3Hospital San Francisco de Asis, Quibdo, Colombia THE EPIDEMIOLOGY OF HUMAN LEPTOSPIROSIS IN TRINIDAD AND TOBAGO BETWEEN 1996-2007: A 602 RETROSPECTIVE STUDY Andrea R. Mohan1, Abiodun Adesiyun2, Anton Cumberbatch3, Dave D. ALGINATE-ENCAPSULATED FORMULATION OF Chadee1 BACTERIA THAT ATTRACT GRAVID AEDES AEGYPTI AND 1The University of The West Indies, St. Augustine, St. Augustine, Trinidad and Tobago, 2 3 AEDES ALBOPICTUS The University of The West Indies, Mt. Hope, Trinidad and Tobago, The Ministry of Health, Port Of Spain, Trinidad and Tobago Loganathan Ponnusamy1, Luma Abu Ayyash1, Dawn M. Wesson2, Coby Schal1, Charles S. Apperson1 1North Carolina State University, Raleigh, NC, United States, 2Tulane University, New Orleans, LA, United States

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COMPARISON OF THE KINETICS AND MAGNITUDE OF METALLO BETA LACTAMASE POSITIVE NOSOCOMIAL ANTIBODY RESPONSES AGAINST THE CONSERVED 47 MDR GRAM NEGATIVE BACTERIA IN A CITY OF A KDA ANTIGEN VERSUS THE VARIABLE 56 KDA ANTIGEN TROPICAL COUNTRY IN SCRUB TYPHUS PATIENTS Debasrita Chakraborty, Satadal Das Hua-Wei Chen, Zhiwen Zhang, Erin Huber, Elissa Mutumanje, Chien- Peerless Hospital and B. K. Roy Research Centre, Kolkata, India Chung Chao, Wei-Mei Ching Naval Medical Research Center, Silver Spring, MD, United States 615

609 ACINETOBACTER SPECIES FROM INVASIVE DISEASE IN RURAL THAILAND PREVALENCE AND RISK FACTORS FOR TRACHOMA IN Duangkamon Siludjai1, Surang Dejsirilert2, Anek Kaewpan1, Possawat RWANDA Jorakate1, Prasert Salika1, Sumalee Boonmar1, Leonard Peruski1 Ruberanziza Eugene1, Mupfasoni Denise1, Nizeyimana Vianney2, Karibushi 1International Emerging Infections Program, Nonthaburi (Bangkok), Thailand, Blaise1, Kabera Michee1, Kaberuka Teddy1, Kabanda Gaspard2, Kramer 2National Institute of Health, Ministry of Public Health, Nonthaburi (Bangkok), Michael2, Ruxin Josh3, Fenwick Alan4, Khumbo Kalua5 Thailand 1The Access project, Kigali, Rwanda, 2Ministry of Health/Treatment Research Aids Center Plus, Kigali, Rwanda, 3The Earth Institute, Columbia University, New York, 616 NY, United States, 4Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom, 5Department of GENETIC RELATIONSHIPS AMONG THREE FAMILIES Ophthalmology, College of Medicine, Blantyre, Malawi OF PLASMIDS IN RICKETTSIA 610 Gregory A. Dasch1, Frankie H. White1, Marina E. Eremeeva1, Kevin Tang1, David C. Bruce2, A. Chris Munk2, J. Chris Detter2, Thomas S. Brettin2 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Joint Genome A COMPARATIVE HIGH-THROUGHPUT SCREEN OF Institute, Los Alamos National Laboratory, Los Alamos, NM, United States 300,000 COMPOUNDS FOR REGULATORS OF THE SALMONELLA ENTERICA PHOP REGULON BY THE PROTOZOA – AMEBA/GIARDIA MOLECULAR LIBRARIES PROBE CENTERS NETWORK James W. Noah1, Robert Citorik2, Carrie Wallace1, Lauren Lebrun2, Miranda Nebane1, Sara McKellip1, Melinda Sosa1, Lynn Rasmussen1, Edward Ryan2, 617 E. Lucile White1, Colleen Jonsson1, Jason Harris2 1Southern Research Specialized Biocontainment Screening Center, Southern Research GENOTYPING AND MOLECULAR CHARACTERIZATION 2 Institute, Birmingham, AL, United States, Infectious Diseases Division, Massachusetts OF GIARDIA INTESTINALIS ISOLATED FROM THE ORANG General Hospital, Boston, MA, United States ASLI (ABORIGINES) IN MALAYSIA 611 Johari Surin1, Mohammed A. Mahdy1, Yvonne A. Lim1, Adura Mohd- Adnan2, K. L. Wan2 1University of Malaya, Kuala Lumpur, Malaysia, 2Universiti Kebangsaan Malaysia, ACTIVITY OF SELECTED ANTIMICROBIAL AGENTS, Kuala Lumpur, Malaysia INCLUDING TWO EXPERIMENTAL KETOLIDES, (ACMCIP Abstract) AGAINST LEPTOSPIRA SEROVARS IN VITRO Peter J. Blatz1, Miriam L. Beckius1, Katrin Mende2, Clinton K. Murray1, 618 Duane R Hospenthal1 1San Antonio Military Medical Center, San Antonio, TX, United States, 2Infectious EXPANSION OF METRONIDAZOLE RESISTANCE GENES Disease Clinical Research Program, Bethesda, MD, United States DURING AMOEBIASIS Jaishree Paul, Lakshmi Rani Iyer 612 School of Life Sciences, Jawaharlal Nehru University, Delhi, India

EFFICACY OF FIRST GENERATION CEPHALOSPORINS 619 IN A HAMSTER MODEL OF LEPTOSPIROSIS Brande M. Harris, Peter J. Blatz, Mary K. Hinkle, Matthew E. Griffi th, THE EFFECT OF LOW TEMPERATURE ON EXCYSTMENT Suzanne McCall, Clinton K. Murray, Duane R. Hospenthal OF PATHOGENIC AND NON-PATHOGENIC SPECIES San Antonio Military Medical Center, San Antonio, TX, United States ACANTHAMOEBA AND THEIR ABILITY TO UNDERGO FEEDING FRENZY AND CANNIBALISM 613 James R. Palmieri, Shaadi F. Elswaifi Virginia College of Osteopathic Medicine, Blacksburg, VA, United States EFFICACY OF MINOCYCLINE AND TIGECYCLINE IN A HAMSTER MODEL OF LEPTOSPIROSIS Charla C. Tully, Mary K. Hinkle, Matthew E. Griffi th, Suzanne McCall, Clinton K. Murray, Duane R. Hospenthal San Antonio Military Medical Center, San Antonio, TX, United States

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MYELOPEROXIDASE ADHERES TO AND DESTROYS ANTI-TUMORIGENIC EFFECTS OF TOXOPLASMA ENTAMOEBA HISTOLYTICA TROPHOZOITES GONDII LYSATE ANTIGEN ON TUMORS PRODUCED BY Judith Pacheco-Yepez1, Rafael Campos-Rodríguez2, Víctor Rivera-Aguilar3, SARCOMA-180 AND CT-26 CELLS Elizabeth Barbosa-Cabrera4, Saúl Rojas-Hernández4, Adriana Jarillo-Luna5 Kyoung-Ho Pyo1, Bong-Kwang Jung1, Joung-Ho Moon1, Jong-Yil Chai1, 1Electron Microscopy Laboratory, Mexican Faculty of Medicine, La Salle University, Eun-Hee Shin2 Mexico City, Mexico, 2Department of Biochemistry, School of Medicine, National 1Seoul National University, College of Medicine, Department of Parasitology and Polytechnic Institute, Mexico City, Mexico, 3Department of Microbiology, UBIPRO, Tropical Medicine, Seoul, Republic of Korea, 2Seoul National University Bundang FES, Iztacala, UNAM, Mexico City, Mexico, 4Graduate Section, School of Medicine, Hospital, Seongnam, Republic of Korea National Polytechnic Institute, Mexico City, Mexico, 5Department of Morphology, School (ACMCIP Abstract) of Medicine, National Polytechnic Institute, Mexico City, Mexico 627 621 DIAGNOSTIC PARASITOLOGY TRAINING: CDC DPDX EVALUATION OF STOOL FIXATIVES FOR MOLECULAR TRAINING PROJECT 2006-2008 DIAGNOSTIC DETECTION OF GIARDIA INTESTINALIS, Stephanie P. Johnston, Henry S. Bishop, Blaine A. Mathison, Jeffrey L. ENTAMOEBA HISTOLYTICA AND ENTAMOEBA DISPAR Jones, Jacquelin Roberts, Alexandre J. da Silva Rebecca Bandea1, Mackevin Ndubuisi2, Cyndy Daniell2, Lauren DiMiceli2, Centers for Disease Control and Prevention-NCZVED-Division of Parasitic Diseases, Mahin Park2, Alexandre J. da Silva3 Atlanta, GA, United States 1Centers for Disease Control and Prevention-NCZVED-Division of Parasitic Diseases and Atlanta Research and Education Foundation, Atlanta, GA, United States, 2Georgia 628 Department of Health, Atlanta, GA, United States, 3Centers for Disease Control and Prevention-NCZVED-Division of Parasitic Diseases, Atlanta, GA, United States ACANTHAMOEBA KERATITIS IN A PREGNANT CONTACT (ACMCIP Abstract) LENS WEARER IN TURKEY 622 Mehmet Tanyuksel1, Ali Aydin2, Melih Hamdi Unal2, Dilaver Ersanli2, Mustafa Ozyurt3, Ozgur Koru1, Engin Araz1, Zeynep Guclu Kilbas1 1 THE EFFECTS OF SALINITY AND PH ON THE Gulhane Military Medical Academy, Division of Medical Parasitology, Ankara, Turkey, 2Gulhane Military Medical Academy, Haydarpasa Training Hospital, Department of SURVIVAL OF PATHOGENIC AND NON-PATHOGENIC Ophthalmology, Istanbul, Turkey, 3Gulhane Military Medical Academy, Haydarpasa ACANTHAMOEBA SPP. Training Hospital, Department of Microbiology and Clinical Microbiology, Istanbul, Shaadi F. Elswaifi 1, James R. Palmieri1, Melissa Jamerson2 Turkey 1Virginia College of Osteopathic Medicine, Blacksburg, VA, United States, 2Virginia Commonwealth University, Richmond, VA, United States 629

PROTOZOA – OTHER PROTOZOA SENSITIVE MULTIPLEX PCR ASSAY FOR GIARDIA AND CRYPTOSPORIDIUM USING DNA CAPTURE Suzanne E. Stroup1, Siripong Tongjai1, Ndealilia Swai2, Athanasia Maro2, 623 John Shao2, Venance Maro2, Eric R. Houpt1 1University of Virginia, Charlottesville, VA, United States, 2Kilimanjaro Christian ANTI-PROTOZOAL EFFECTS IN KOREA BLACK Medical Centre, Moshi, United Republic of Tanzania GINSENG-TREATED MICE Eun-Hee Shin1, Kyoung-Ho Pyo2, Bong-Kwang Jung2, Joung-Ho Moon2, 630 Friday, November 20 Jong-Yil Chai2 1Seoul National University College of Medicine and Seoul National University Bundang A LOW-PROTEIN MALNUTRITION MODEL OF Hospital, Seoul, Republic of Korea, 2Seoul National University College of Medicine, CRYPTOSPORIDIAL INFECTION IN WEANED MICE Seoul, Republic of Korea Eric A. JohnBull1, Jesus Emmanuel Sevilleja1, Reinaldo B. Oriá2, Paul S. (ACMCIP Abstract) Hoffman1, Richard L. Guerrant1, Cirle A, Warren1 1University of Virginia, Charlottesville, VA, United States, 2Federal University of Ceara, 624 Fortaleza, Brazil (ACMCIP Abstract) TOXOPLASMA GONDII INFECTION INDUCED AUTOPHAGIC CELL DEATH OF HOST CELLS 631 Myoung-Hee Ahn, Youn-Jin Lee, Hyun-Ouk Song, Han-Kyu Choi, Jae- Sook Ryu SIMULTANEOUS LUMINEX BASED DETECTION OF Hanyang University College of Medicine, Seoul, Republic of Korea MULTIPLE ENTEROPATHOGENS - PROTOZOA AND MICROSPORIDIA 625 Mami Taniuchi1, Eric Houpt1, Rashidul Haque2 1University of Virginia, Charlottesville, VA, United States, 2International Centre for CROSSTALK OF MAST CELL WITH VAGINAL Diarrhoeal Disease Research in Bangladesh, Dhaka, Bangladesh EPITHELIAL CELL IN INFLAMMATION CAUSED BY TRICHOMONAS VAGINALIS Ik-Hwan Han, Su-Jeong Im, Han-Kyu Choi, Myoung-Hee Ahn, Jae-Sook Ryu Hanyang University College of Medicine, Seoul, Republic of Korea

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EFFECTS OF TOXOPLASMA GONDII INFECTION ON THE SHORT INTERFERING RNAS, AS WELL AS LONGER DS PROGRESS OF EXPERIMENTAL ALZHEIMER’S DISEASE RNAS, DELIVER GENE SILENCING OF CATHEPSIN D OF IN MICE SCHISTOSOMA MANSONI Bong-Kwang Jung1, Kyoung-Ho Pyo1, Ki Young Shin1, Yoo-Hun Suh1, Mary A. Ayuk1, Sutas Suttiprapa1, Kristine J. Kines1, Gabriel Rinaldi1, Maria Jong-Yil Chai1, Eun-Hee Shin2 E. Morales2, Clarence M. Lee3, Paul J. Brindley1 1Seoul National University, College of Medicine, Seoul, Republic of Korea, 2Seoul 1The George Washington University, Washington, DC, United States, 2Tulane National University Bundang Hospital, Republic of Korea University, New Orleans, LA, United States, 3Howard University, Washington, DC, (ACMCIP Abstract) United States (ACMCIP Abstract) TREMATODES - SCHISTOSOMIASIS 638

633 INNATE IMMUNE PRIMING OF ADAPTIVE RESPONSES TO HELMINTH INFECTION DRUGS FOR TREATING SCHISTOSOMA HAEMATOBIUM Christine E. Ferragine, Stephen J. Davies AND S. MANSONI INFECTIONS Uniformed Services University of the Health Sciences, Bethesda, MD, United States Anthony Danso-Appiah1, Jürg Utzinger2, Paul Garner1, Piero L. Olliaro3 (ACMCIP Abstract) 1Liverpool School of Tropical Medicine, Liverpool, United Kingdom, 2Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland, 639 3UNICEF/UNDP/World Bank/WHO Special Programme on Research and Training in Tropical Diseases, World Health Organization, Geneva, Switzerland MODELING SCHISTOSOMIASIS TRANSMISSION AND CONTROL IN A DISTRIBUTED ENVIRONMENT USING A 634 STRATIFIED WORM BURDEN APPROACH David Gurarie, Charles H. King, Xiaoxia Wang COMPARISON OF TWO COMMERCIALLY AVAILABLE Case Western Reserve University, Cleveland, OH, United States URINE CCA ASSAYS FOR THE DETECTION OF S. MANSONI INFECTION IN WESTERN KENYA 640 Hillary L. Shane1, Jennifer R. Verani1, Bernard Abudho2, Susan P. Montgomery1, Anna K. Jolly1, Pauline M. Mwinzi2, Sara E. Butler1, Daniel G. PRELIMINARY FINDINGS OF COST OF DISTRIBUTION 3 2 1 Colley , Diana M. Karanja , W. Evan Secor STUDY FOR THREE ANTHELMINTHIC DRUGS IN 1Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Kenya Medical Research Institute, Kisumu, Kenya, 3Center for Tropical PLATEAU AND NASARAWA STATES, NIGERIA and Emerging Global Diseases and Department of Microbiology, University of Georgia, Darin Evans1, Deb McFarland2, Abel Eigege3, Emmanual Miri3, William Athens, GA, United States Adamani3, Frank Richards1, Johnathan Jiya4 1The Carter Center, Atlanta, GA, United States, 2Emory University, Atlanta, GA, United 635 States, 3The Carter Center, Jos, Nigeria, 4Ministry of Health, Jos, Nigeria

DO ENDOGENOUS ANTI-OXIDANTS OF SCHISTOSOMA 641 MANSONI PRIMARY SPOROCYSTS PROTECT AGAINST EXPLORING THE IMPACT OF INFECTION-INDUCED EXTERNAL OXIDATIVE STRESS? IMMUNITY ON ENDEMIC LEVELS OF SCHISTOSOMA Timothy P. Yoshino JAPONICUM University of Wisconsin, Madison, WI, United States IN HILLY AND MOUNTAINOUS ENVIRONMENTS IN CHINA 636 Shuo Wang, Edmund Y. W. Seto, Elizabeth J. Carlton, Robert C. Spear School of Public Health, University of California, Berkeley, CA, United States GENERATION AND CHARACTERIZATION OF IGM AND IGG MONOCLONAL ANTIBODIES THAT BIND 642 FUCOSYLATED GLYCAN EPITOPES FROM SCHISTOSOMA THE IMPACT OF MOBILITY ON SCHISTOSOMA JAPONICUM MANSONI AND KEY HOLE LIMPET HEMOCYANIN INFECTION: A CASE-CONTROL STUDY OF INDIVIDUAL- Nelum Dorabawila1, Msano Mandalasi1, Richard D. Cummings2, A. Kwame LEVEL INFECTION RISK Nyame1 1University of Maryland Eastern Shore, Princess Anne, MD, United States, 2Emory Edmund Y. W. Seto1, Elizabeth J. Carlton1, Bo Zhong2, Robert C. Spear1 University, Atlanta, GA, United States 1University of California, Berkeley, Berkeley, CA, United States, 2Sichuan Institute of Parasitic Diseases, Sichuan Center for Disease Control and Prevention, Chengdu, China

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IDENTIFICATION OF GENES AND PROTEINS FURTHER EVALUATION OF RVF MP12 LIVE- DIFFERENTIALLY EXPRESSED IN SCHISTOSOMA ATTENUATED VACCINE IN CATTLE AND SHEEP IN MANSONI ADULT WORMS TREATED WITH EGYPT PRAZIQUANTEL Atef Soliman1, Adel Azab2, Emad Mohareb1, Magdi Saad1, Jeffrey Tjaden1, Regina C. Lage1, Rosiane Aparecida Pereira1, Giulliana Tessarini Almeida2, Hanan El-Mohamady1, Deidra Shuck-Lee1, Kenneth Earhart1, Samuel Yingst3 Helder Nakaya2, Sérgio Verjovski-Almeida2, Guilherme Corrêa Oliveira1 1United States Naval Medical Research Unit -3, New York, NY, United States, 1Fiocruz, Belo Horizonte, Brazil, 2Instituto de Química-USP, São Paulo, Brazil 2Veterinary Serum and Vaccine Research Institute, Cairo, Egypt, 3United States Army (ACMCIP Abstract) Medical Research Institute for Infectious Diseases, Fort Detrick, MD, United States

VIRUSES - OTHER 650 ANTIBODY TO HEPATITIS E VIRUS IN TRAVELERS 644 Elizabeth Day Barnett1, Jan Drobeniuc2, Saleem Kamili2, Davidson H. Hamer1, Lin Chen3, William MacLeod4, Nina Marano2, Laura Kogelman5, SEROLOGIC SURVEILLANCE FOR EQUINE INFLUENZA Winnie W. Ooi6, Emad Yanni2, AW Karchmer7, Christine Benoit1, Mary E. 8 VIRUS IN MEXICO Wilson 1Boston Medical Center, Boston, MA, United States, 2Centers for Disease Control and 1 2 2 Bradley J. Blitvich , Maria A. Loroño-Pino , Jose A. Farfan-Ale , Julian E. Prevention, Atlanta, GA, United States, 3Mt. Auburn Hospital, Cambridge, MA, United 2 2 3 Garcia-Rejon , Fernando Puerto , Luis Ibarra-Juarez , Antonio J. Cortes- States, 4Boston University School of Public Health, Boston, MA, United States, 5Tufts 4 5 3 Guzman , Jeffrey Root , Ildefonso Fernandez-Salas Medical Center, Boston, MA, United States, 6Lahey Clinic, Burlington, MA, United 1 2 Iowa State University, Ames, IA, United States, Universidad Autonoma de Yucatan, States, 7Beth Israel Deaconess Hospital, Boston, MA, United States, 8Harvard School of 3 Merida, Mexico, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Public Health, Boston, MA, United States Mexico, 4Departamento de Control de Vectores - SSA, Chilpancingo, Mexico, 5United States Department of Agriculture, Fort Collins, CO, United States 651 645 SUSCEPTIBILITY OF AOTUS NANCYMAAE OWL MONKEYS TO NORTH AMERICAN AND SOUTH THE INCREASING DISEASE BURDEN OF IMPORTED AMERICAN STRAINS OF EASTERN EQUINE CHRONIC HEPATITIS B VIRUS INFECTION-UNITED ENCEPHALITIS VIRUS STATES, 1973-2007 Patricia V. Aguilar, Benjamin Espinoza, Tadeusz Kochel Tarissa Mitchell, John Painter, Gregory Armstrong, Annemarie Wasley, Naval Medical Research Center Detachment, Lima, Peru Dale Hu, Christina Phares, Michelle Weinberg Centers for Disease Control and Prevention, Atlanta, GA, United States 652 646 PREDICTION, ASSESSMENT OF THE RIFT VALLEY ROLE OF THE MUTATIONS IN E2 PROTEIN IN FEVER ACTIVITY IN EAST AND SOUTHERN AFRICA ADAPTATION OF CHIKUNGUNYA VIRUS TO AE. 2006 - 2008 AND POSSIBLE VECTOR CONTROL ALBOPICTUS AND AE. AEGYPTI MOSQUITOES STRATEGIES 1 2 1 1 Konstantin A. Tsetsarkin, Stephen Higgs Assaf Anyamba , Kenneth J. Linthicum , Jennifer Small , Edwin Pak , Compton J. Tucker1, Jean P. Chretien3, Seth C. Britch2, Robert Breiman4,

University of Texas Medical Branch, Galveston, TX, United States Friday, November 20 5 5 6 7 (ACMCIP Abstract) Allan Hightower , Stephan de La Rocque , Pierre Formenty , Karl Haagsma , Mark Latham8, Henry B. Lewandowski9, Rosemary Sang10, David Schnabel11, 12 647 Jason Richardson 1NASA Goddard Space Flight Center, Greenbelt, MD, United States, 2USDA-ARS Center for Medical, Agricultural and Veterinary Entomology, Gainesville, FL, United FATAL HUMAN CASES OF VENEZUELAN EQUINE States, 3Department of Defense Global Emerging Infections Surveillance and Response ENCEPHALITIS IN PERU System, Silver Spring, MD, United States, 4Centers for Disease Control and Prevention- 5 1 2 2 Kenya, Nairobi, Kenya, Food and Agriculture Organisation of the United Nations, Stalin Vilcarromero , Patricia V. Aguilar , V. Alberto Laguna-Torres , Hugo 6 7 2 3 4 5 Rome, Italy, World Health Organization, Geneva, Switzerland, Youngstown Air Razuri , Yadira Valderrama , Eduardo Gotuzzo , Luis Suárez , Manuel 8 6 2 2 Reserve Station, Vienna, OH, United States, Manatee County Mosquito Control, West Cespedes , Juan Perez , Tadeusz Kochel 9 1Naval Medical Research Center Detachment, Iquitos, Peru, 2Naval Medical Research Palmento, FL, United States, Chatham County Mosquito Control, Savannah, GA, 10 11 Center Detachment, Lima, Peru, 3Hospital de Apoyo Yurimaguas, Yurimaguas, United States, Kenya Medical Research Institute, Nairobi, Kenya, USAMRU-K - 12 Peru, 4Universidad Peruana Cayetano Heredia, Lima, Peru, 5Direccion General de GEIS, Nairobi, Kenya, Armed Forces Research Institute of Medical Sciences, United Epidemiologia, Lima, Peru, 6Instituto Nacional de Salud, Lima, Peru States Army Medical Component, Bangkok, Thailand

648

PREVALENCE OF TICK-BORNE VIRUSES AMONG PATIENTS WITH UNDIFFERENTIATED FEVER IN BULGARIA Emad W. Mohareb1, Iva Christova2, Iva Trifonova2, E. Tasseva2, Rasha Younan1, Jeffery Tjaden1 1NAMRU-3, Cairo, Egypt, 2NCIPD, Sofi a, Bulgaria

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653 Poster Session B ACMCIP Abstracts – Molecular, Cellular and Immunoparasitology GENETIC CHARACTERIZATION OF A NOVEL 438, 466, 475, 477, 488, 489, 491, 492, 493, 494, 495, 496, 497, 498, 500, 502, HANTAVIRUS STRAIN ASSOCIATED WITH HUMAN 511, 523, 524, 525, 529, 530, 531, 535, 543, 551, 553, 554, 555, 556, 557, 558, ILLNESS IN BOLIVIA 559, 560, 563, 566, 568, 571, 595 Cristhopher Cruz1, Brett M. Forshey2, Efrain Vallejo3, Roberto Agudo3, Roger Castillo1, Alfredo Huaman1, Jorge Vargas4, Tadeusz Kochel1 1Naval Medical Research Center Detachment, Lima, Peru, 2Naval Medical Research CME/Courses Committee Meeting Center Detachment, Lima and Iquitos, Peru, 3Servicio Departamental de Salud, Cochabamba, Bolivia, 4Centro Nacional de Enfermedades Tropicales, Santa Cruz, Bolivia Room 8211 Friday, November 20, 12:15 p.m. - 1:15 p.m. 654 Public Relations Committee Meeting POPULATION-BASED STUDIES TO INVESTIGATE THE Room 8212 EXPANSION OF A NEWLY-INTRODUCED DENGUE Friday, November 20, 12:15 p.m. - 1:15 p.m. VIRUS SEROTYPE IN IQUITOS, PERU Brett M. Forshey1, Amy C. Morrison2, Claudio Rocha2, Steve Stoddard3, Rebeca Carrion2, Isabel Bazan2, Stalin Vilcarromero2, Thomas W. Scott3, Late Breaker Abstract Session 78 Tadeusz Kochel4 1Naval Medical Research Center Detachment, Lima and Iquitos, Peru, 2Naval Medical Late Breakers in Clinical Tropical Medicine Research Center Detachment, Iquitos, Peru, 3University of California, Davis, Davis, CA, United States, 4Naval Medical Research Center Detachment, Lima, Peru Delaware A Friday, November 20, 12:15 p.m. - 1:15 p.m. WATER, SANITATION AND HYGIENE This session is specifi cally designed for presentations of new data obtained after the closing date for abstract submission. Presentations feature reports of 655 clinical trials, preliminary data on new outbreaks of disease or individual case reports of interest. See the Late Breaker handout in your registration packet for the presentation schedule. THE USE OF INTRAVAGINAL PRODUCTS AND VAGINAL HYGIENE PRACTICES AMONGST NIGERIAN WOMEN CHAIR Ngozi M. Otuonhye Barbara L. Herwaldt Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria Centers for Disease Control and Prevention, Atlanta, GA, United States Jason D. Maguire 656 Naval Medical Center Portsmouth, Portsmouth, VA, United States NEIGHBORHOOD WATER AND SANITATION AND Mid-Day Session 79 DIARRHEAL DISEASE IN AN URBAN AND DEVELOPING REGION OF COASTAL ECUADOR Preparation and Review of Scientifi c Manuscripts for the Darlene Bhavnani1, William Cevallos2, Joseph N. Eisenberg1 American Journal of Tropical Medicine & Hygiene 1University of Michigan, Ann Arbor, MI, United States, 2Universidad San Francisco de Quito, Quito, Ecuador Delaware B Friday, November 20, 12:15 p.m. - 1:15 p.m. 657 This symposium is aimed at trainees and others interested in understanding OUTBREAK OF A CYCLOSPORA CAYETANENSIS WITHIN A better how manuscripts are reviewed, edited and processed by the society’s PERUVIAN MILITARY FACILITY IN LIMA, PERU journal. Pointers on preparation and review of manuscripts will be stressed. Mariana Ramos1, Victor Gonzaga1, Carmen Lucas1, Maria Bernal1, Christian The following topics will be covered: 1) Why publish your work in our Loret-de-Mola1, Marianela Ore2, Rina Meza1, Ryan C. Maves1, Paul Graf1, society’s journal; 2) Why and where to publish, i.e. selection of the “right” Joel M. Montgomery1 journal for your work; 3) Examples of a paper in progress; how to prepare and 1Naval Medical Research Center Detachment Peru, Lima, Peru, 2Health Intelligence how to write a good paper; 4) The submission and review processes and how Section-Peruvian Army, Lima, Peru they work; 5) How to properly review a paper; 6) How to respond to reviewer comments; and 6) The publication process: what happens after your paper is 658 accepted. CHAIR RELATIONSHIP BETWEEN SOCIO-ECONOMIC FACTORS AND TIME-TO-INFECTION WITH GIARDIA INTESTINALIS Cathi Siegel American Journal of Tropical Medicine and Hygiene, Cleveland, OH, United AMONG CHILDREN IN PERU States Geoffrey Kahn1, Lilia Cabrera2, Manuela Verastegui3, Ynes R. Ortega4, 5 1 1 James Kazura Robert H. Gilman , Lihua Xiao , Vitaliano A. Cama Case Western Reserve University, Cleveland, OH, United States 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Asociacion Benefi ca Prisma, Lima, Peru, 3Universidad Peruana Cayetano Heredia, Lima, Peru, 4University of Georgia, Griffi n, GA, United States, 5Johns Hopkins University, Baltimore, MD, United States

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12:15 p.m. Meet the Professors 81 WHY SELECT THE AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (AJTMH) FOR YOUR PAPER: Meet the Professors B: Enigmatic and Teaching Cases SELECTING THE RIGHT JOURNAL FOR YOUR WORK Virginia C James Kazura Case Western Reserve University, Cleveland, OH, United States Friday, November 20, 12:15 p.m. - 1:15 p.m. 12:25 p.m. A panel of professors will present one clinical case each of a tropical disease specifi c to a particular region that they have found a challenge to manage or MANUSCRIPT PROCESSING AT AJTMH diagnose. If there is time, participants may be able to present enigmatic cases Cathi Siegel for the audience and panel to consider. American Journal of Tropical Medicine and Hygiene, Cleveland, OH, United States CHAIR Davidson H. Hamer 12:35 p.m. Boston University School of Public Health, Boston, MA, United States WHAT CONSTITUTES A WELL- VERSUS POORLY- PANELISTS WRITTEN MANUSCRIPT: RESPONDING TO REVIEWERS’ Susan McLellan COMMENTS Tulane University School of Medicine, New Orleans, LA, United States James Kazura Hans D. Nothdurft Case Western Reserve University, Cleveland, OH, United States University of Munich, München, Germany Joseph M. Vinetz University of California at San Diego, La Jolla, CA, United States 12:45 p.m. Mid-Day Session 81A THE REVIEW: EDITORIAL, CORRESPONDING AUTHOR Case Studies for Global Health: Building Relationships, AND REVIEWER PERSPECTIVES Sharing Knowledge James Kazura Case Western Reserve University, Cleveland, OH, United States Wilson AB Joseph M. Vinetz Friday, November 20, 12:15 p.m. - 1:15 p.m. University of California at San Diego, La Jolla, CA, United States 12:55 p.m. The Alliance for Case Studies for Global Health -- (a collaboration of the Association of University Technology Managers, the Bill & Melinda Gates OPEN ACCESS MOVEMENT AND AJTMH POLICY ON Foundation, Global Health Progress, International AIDS Vaccine Institute OPEN ACCESS (IAVI), and TDR: For research on diseases of poverty) – set out almost Cathi Siegel two years ago to prepare a set of multi-sector “case studies” focusing on American Journal of Tropical Medicine and Hygiene, Cleveland, OH, United global health research, development, delivery and fi nancing. The demand States for widely available case studies regarding the way various stakeholders (e.g. private funders, the WHO, academia, the pharmaceutical and biotech 1:05 p.m. sectors, public-private-partnerships and governments) address global health concerns is well known. This demand has been voiced by both 1) stakeholders OPEN FORUM WITH AUDIENCE currently involved with global health projects who continually evaluate how to most effi ciently build and manage technologies and relationships, and 2) Friday, November 20 Late Breaker Abstract Session 80 organizations and companies that are not yet involved in global health efforts but are interested in learning how others have participated. This workshop Late Breakers in Basic Science/Molecular Biology will unveil the publication for the fi rst time and highlight some of the case study participants’ experiences. Selected case study participants will discuss Virginia AB the topics of global health access, discovery/development, intervention/ prevention, and systems strengthening and capacity building from a variety of Friday, November 20, 12:15 p.m. - 1:15 p.m. perspectives. This session is specifi cally designed for brief presentations of new data obtained after the closing date for abstract submission. See the Late Breaker CHAIR handout in your registration packet for the presentation schedule. Erik Iverson Bill & Melinda Gates Foundation, Seattle, WA, United States CHAIR Labeeb Abboud Gregory D. Ebel International AIDS Vaccine Institute, New York, NY, United States University of New Mexico School of Medicine, Albuquerque, NM, United States Stefan Kappe Poster Session B Viewing Seattle Biomedical Research Institute, Seattle, WA, United States Exhibit Hall B South Friday, November 20, 1:30 p.m. - 7 p.m.

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Symposium 82 Symposium 83

Targets and Mechanisms of Acquired Immunity to Malaria Clinical Group I Salon 1 Supported with funding from the International Association for Friday, November 20, 1:30 p.m. - 3:15 p.m. Medical Assistance to Travelers Salon 2 Individuals living in malaria-endemic areas eventually develop effective Friday, November 20, 1:30 p.m. - 3:15 p.m. immunity that protects against severe and symptomatic malaria. Presently there is only a limited understanding of the key targets of protective immune This session features the Marcolongo Lecture, named for Vincenzo responses and specifi c mechanisms involved in mediating immunity in humans. Marcolongo, who founded the International Association for Medical This symposium will review our current understanding and recent insights Assistance to Travelers (IAMAT) and organized physicians from all over the into the targets and mechanisms of immunity. world into a network assisting travelers. The session also features an update from the GeoSentinel Surveillance group and Global TravEpiNet group. CHAIR James G. Beeson CHAIR Walter and Eliza Hall Institute, Parkville, Australia Joseph M. Vinetz Christopher L. King University of California at San Diego, La Jolla, CA, United States Case Western Reserve University, Cleveland, OH, United States 1:30 p.m. 1:30 p.m. VINCENZO MARCOLONGO MEMORIAL LECTURE: APPROACHES TO DEFINING THE TARGETS OF PARADIGM SHIFTS IN TUBERCULOSIS DRUG IMMUNITY TO MALARIA SUSCEPTIBILITY TESTING: NEW DOS AND DON’TS Kevin Marsh David A.J. Moore Kenya Medical Research Institute, Kilifi , Kenya Imperial College London and Universidad Peruana, Lima, Peru 1:50 p.m. 2:15 p.m. BIOLOGICALLY RELEVANT CORRELATES OF GEOSENTINEL SURVEILLANCE REPORT NATURALLY ACQUIRED IMMUNITY TO PLASMODIUM David O. Freedman FALCIPARUM IN HUMANS University of Alabama Birmingham, Birmingham, AL, United States James W. Kazura Case Western Reserve University, Cleveland, OH, United States 3 p.m. 2:10 p.m. TRAVEPINET UPDATE Edward T. Ryan GROWTH INHIBITORY ANTIBODIES AGAINST BLOOD- Massachusetts General Hospital, Boston, MA, United States STAGE P. FALCIPARUM Carole A. Long Symposium 84 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States American Committee on Arthropod-Borne Viruses 2:30 p.m. (ACAV) I: Business Meeting, Awards and Shope MEROZOITE INVASION LIGANDS AS TARGETS OF Fellowship Presentations PROTECTIVE IMMUNITY AGAINST P. FALCIPARUM Salon 3 James G. Beeson Friday, November 20, 1:30 p.m. - 3:15 p.m. Walter and Eliza Hall Institute, Parkville, Australia The American Committee on Arthropod-Borne Viruses provides a forum 2:50 p.m. for exchange of information among people interested in arbovirus research. CORRELATES OF PROTECTIVE IMMUNITY TO This session will include the business meeting/award presentations and PLASMODIUM VIVAX presentations by previous winners of the Robert E. Shope International Fellowship in Infectious Diseases to describe their research on arbovirology Christopher L. King and emerging diseases. These awardees have developed and executed Case Western Reserve University, Cleveland, OH, United States international work in the fi eld of arbovirology and strive to reinvigorate international research in tropical infectious diseases. The session will end with an informal social designed to encourage new and young members of our community to interact with fellow arbovirologists and become involved in the ACAV system.

CHAIR Ann Powers Centers for Disease Control and Prevention, Fort Collins, CO, United States Laura D. Kramer Wadsworth Center, Slingerlands, New York, United States

146 ASTMH 58th Annual Meeting www.astmh.org

1:30 p.m. 2:20 p.m. AWARDS PRESENTATION AND BUSINESS MEETING THE ARTESUNATE-AMODIAQUINE FIXED-DOSE Ann Powers COMBINATION FIELD MONITORING PROGRAM: Centers for Disease Control and Prevention, Fort Collins, CO, United States OBJECTIVES, METHODS AND FIRST RESULTS FROM LIBERIA AND SENEGAL 2:05 p.m. Francois Bompart BLOOD FEEDING BEHAVIOR OF POTENTIAL WEST sanofi -aventis, Paris, France NILE VIRUS VECTORS IN GUATEMALA 2:50 p.m. Rebekah J. Kent Centers for Disease Control and Prevention, Fort Collins, CO, United States BEYOND ANTIMALARIALS: PERSPECTIVES FOR IMPROVING PHARMACOVIGILANCE IN SUB-SAHARAN 2:25 p.m. AFRICA NEW UNDERSTANDING OF THE EPIDEMIOLOGY OF Fred Binka RIFT VALLEY FEVER INDEPTH Network, Accra, Ghana Angelle D. LaBeaud Children’s Hospital Oakland Research Institute, Oakland, United States Symposium 86

2:45 p.m. The Global Burden of Anemia: Bridging Pathogenesis and SOCIAL NETWORKING Pathology Symposium 85 Supported with funding from the Burroughs Wellcome Fund Delaware B Pharmacovigilance of New Antimalarials in the Field: Friday, November 20, 1:30 p.m. – 3:15 p.m. Challenges and Opportunities Anemia is a major disease pathology associated with a variety of infections, Delaware A malnutrition and poverty. Assessing the global burden of anemia is critical to revealing the major causes and assessing mechanisms of intervention. Friday, November 20, 1:30 p.m. - 3:15 p.m. Parasitic infections are signifi cant contributors to anemia and linking parasite genomics and biology to pathologies of anemia, is urgently needed for effective Pharmacovigilance in most sub-Saharan African countries is insuffi ciently vaccine development in many parasitic diseases. This requires understanding operative. This situation poses acute problems for assessing the “real life” the complexities of pathogenic mechanisms, acute and chronic anemia safety profi le of new drugs, such as antimalarials, that will not be used in and treatment strategies. This symposium will bring together strategies in developed countries with pharmacovigilance systems. The symposium will fi rst measuring anemia due to distinct infectious agents, underlying mechanisms of review the status of pharmacovigilance systems in Africa. It will also provide anemia with implications for vaccine development, as well as the utilization of the fi rst results of a large-scale proactive pharmacovigilance plan launched in model systems to understand human disease. 2008 on a fi xed-dose ACT that uses innovative ways to gather good quality safety and effectiveness data in the fi eld. It will fi nally discuss how this fi rst CHAIR experience can pave the way for monitoring plans for newer antimalarial drugs that will be launched in the coming years, and how these initiatives contribute Kasturi Haldar to build capacity on pharmacovigilance in Africa. University of Notre Dame, Notre Dame, IN, United States Peter Hotez CHAIR George Washington University, Washington, DC, United States Friday, November 20 Wilfred Mbacham University of Yaoundé, Yaoundé, Cameroon 1:30 p.m. Ambrose Talisuna ASSESSING THE GLOBAL BURDEN OF ANEMIA Medicines for Malaria Venture, Kampala, Uganda Michael Boele van Hensbroek Emma Children’s Hospital AMC, Amsterdam, The Netherlands 1:30 p.m. LESSONS DRAWN FROM A COMPARISON OF THE 1:55 p.m. STATUS OF PHARMACOVIGILANCE SYSTEMS IN NORTH THE ANEMIA OF HOOKWORM: MECHANISMS OF AFRICA AND IN SUB-SAHARAN AFRICA BLOOD LOSS Rachida Soulaymani Peter J. Hotez National Pharmacovigilance Center, Rabat, Morocco The George Washington University, Washington, DC, United States 1:55 p.m. 2:20 p.m. ANTIMALARIALS PHARMACOVIGILANCE IN SUB- MALARIAL IMMUNITY, INFLAMMATION AND ANEMIA SAHARAN AFRICA: CHALLENGES AND ONGOING Kasturi Haldar INITIATIVES University of Notre Dame, Notre Dame, IN, United States Shanti Pal World Health Organization, Geneva, Switzerland

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2:45 p.m. Symposium 88 ANEMIA ASSOCIATED WITH MALARIA AND SCHISTOSOMIASIS AND HOW TO MORE EFFECTIVELY Molecular Pathogenesis of Leishmaniasis ADDRESS BEST TREATMENT OPTIONS. Virginia C Jennifer F. Friedman Brown University, Providence, United States Friday, November 20, 1:30 p.m. - 3:15 p.m. This symposium is designed for leishmania researchers, as well as physicians, Symposium 87 interested in leishmaniasis. The research areas covered by this symposium include promastigote virulence factors, complement resistance mechanisms Research Agenda of the Schistosomiasis Consortium for and amastigote survival in macrophage phagolysosomes. Operational Research and Elimination (SCORE) CHAIR Virginia AB Chaoqun Yao Friday, November 20, 1:30 p.m. - 3:15 p.m. University of Wyoming, Laramie, WY, United States Jeffrey Beetham This symposium will review the objectives and research agenda of the Iowa State University, Ames, IA, United States newly-created Schistosomiasis Consortium for Operational Research and Elimination. The aim of the session will be to review the present state-of 1:30 p.m. the-art in the areas of operational research toward schistosomiasis control, COMPLEMENT RESISTANCE MECHANISMS IN including highlights of current approaches to measurement of drug impact on parasite diversity, the monitoring of snail populations and transmission LEISHMANIA CHAGASI parameters during control and the assessment of infection-associated Jeffrey Beetham morbidities. Iowa State University, Ames, IA, United States

CHAIR 1:55 p.m. Charles H. King THE ROLE OF LEISHMANIA GLYCOLIPIDS IN THE Case Western Reserve University, Cleveland, OH, United States INFECTIOUS CYCLE Daniel G. Colley Stephen Beverley University of Georgia, Athens, GA, United States Washington University, St. Louis, MO, United States 1:30 p.m. 2:20 p.m. IMPACT OF LARGE-SCALE CONTROL PROGRAMS ON VIRULENCE DETERMINANTS IN THE PLASMA PARASITE POPULATION STRUCTURE AND GENETIC MEMBRANE OF LEISHMANIA PROMASTIGOTES DIVERSITY Chaoqun Yao Ronald E. Blanton University of Wyoming, Laramie, WY, United States Case Western Reserve University, Cleveland, OH, United States 2:45 p.m. 1:55 p.m. AMASTIGOTE SURVIVAL IN MACROPHAGE MOLECULAR DETECTION OF SNAIL INFECTION BY PHAGOLYSOSOMES SCHISTOSOMA SPECIES — STATE-OF-THE-ART FOR Peter Kima XENOMONITORING OF TRANSMISSION University of Florida, Gainesville, FL, United States David Rollinson The Natural History Museum, London, United Kingdom Scientifi c Session 89 2:20 p.m. American Committee of Molecular, Cellular and CURRENT APPROACHES TO MEASURING THE Immunoparasitology (ACMCIP): Cellular Parasitology II DISABLING ‘SUBTLE’ MORBIDITIES OF CHRONIC SCHISTOSOMIASIS Supported with funding from the Burroughs Wellcome Fund Charles H. King Washington 1 Case Western Reserve University, Cleveland, OH, United States Friday, November 20, 1:30 p.m. - 3:15 p.m. 2:45 p.m. CHAIR WHO’S PERSPECTIVE ON OPERATIONAL RESEARCH Nilda E. Rodriguez GOALS FOR SCHISTOSOMIASIS Veterans Affairs Medical Center Iowa City, Iowa City, IA, United States Peter Melby Dirk A. Engels University of Texas Health Science Center, San Antonio, TX, United States World Health Organization, Geneva, Switzerland

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1:30 p.m. 2:30 p.m.

1150 661

NEUTROPHIL-DERIVED CCL3 IS ESSENTIAL FOR THE DOMINANT ALTERNATIVE MACROPHAGE ACTIVATION RAPID RECRUITMENT OF DENDRITIC CELLS TO THE IN PROGRESSIVE VISCERAL LEISHMANIASIS IS SITE OF LEISHMANIA INOCULATION IN RESISTANT MICE MEDIATED BY PARASITE-INDUCED STAT6 ACTIVATION Mélanie Charmoy1, Saskia Brunner-Agten1, David Aebisher1, Floriane AND ARGINASE EXPRESSION Auderse1, Pascal Launois1, Geneviève Milon2, Amanda E. I. Proudfoot3 and Elvia Y. Osorio1, Weiguo Zhao1, Claudia M. Espitia1, Omar A. Saldarriaga1, Fabienne Tacchini-Cottier1 Leo Hawel2, Craig V. Byus2, Bruno L. Travi1, Peter C. Melby1 1Department of Biochemistry, WHO Immunology Research and Training Center, 1South Texas Veterans Health Care System/University of Texas Health Science Center, University of Lausannne, Epalinges, Switzerland, 2Institut Pasteur, Département de San Antonio, TX, United States, 2University of California-Riverside, Riverside, CA, Parasitologie et Mycologie, Unité d’Immunophysiologie et Parasitisme Intracellulaire, United States Paris, France, 3Merck-Serono Geneva Research Center, Geneva, Switzerland 2:45 p.m. 1:45 p.m. 662 1151 PHOSPHATIDYLSERINE EXPOSURE BY AMASTIGOTES RELEASE OF TRAP FROM THE SPOROZOITE SURFACE OF LEISHMANIA AMAZONENSIS IS INDUCED BY HOST IS REQUIRED FOR GLIDING MOTILITY AND INVASION IMMUNE RESPONSES OF TARGET ORGANS Joao L. Wanderley1, Poliana Deolindo2, Marcello Barcinski3, Lynn Soong4 Ijeoma Ejigiri, Kwadwo Kwakye, Alida Coppi, Brandy Bennett, Photini 1Federal University of Rio de Janeiro, Morphological Sciences Program, Rio de Janeiro, Sinnis Brazil, 2Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, 3University of Sao Paulo, Sao Department of Medical Parasitology, New York University School of Medicine, New Paulo, Brazil, 4University of Texas Medical Branch, Galveston, TX, United States York, NY, United States 3 p.m. 2 p.m. ACMCIP ANNUAL BUSINESS MEETING Rick Fairhurst 659 National Institutes of Health, Rockville, MD, United States STIMULATION OF MONOCYTES BY FILARIAL Symposium 90 EXCRETORY-SECRETORY PRODUCTS: A POTENTIAL ROLE IN MODULATION OF THE LYMPHATIC Johns Hopkins Malaria Research Institute Symposium on ENDOTHELIUM? Plasmodium-Mosquito Interactions Tiffany S. Weinkopff1, Patrick Lammie2 1University of Georgia, Athens, GA, United States, 2Centers for Disease Control and Washington 2 Prevention, Atlanta, GA, United States Friday, November 20, 1:30 p.m. - 3:15 p.m.

2:15 p.m. Transmission of Plasmodium, the causative agent of malaria, is entirely dependent on its successful development in its mosquito vector. Thus, this part 660 of the life cycle is a potential weak link in the transmission chain. Traditional Friday, November 20 control measures are either only partially effective (drugs, insecticides) or MACROPHAGE CHOLESTEROL MEDIATES THE ENTRY, extremely hard to develop (vaccines). These considerations emphasize the PHAGOSOME MATURATION, AND INTRACELLULAR importance of understanding parasite-insect vector interactions because such knowledge could lead to the development of novel control strategies. Exciting SURVIVAL OF LEISHMANIA CHAGASI PARASITES IN new discoveries are being made in this area of knowledge and the symposium A STAGE-SPECIFIC AND VIRULENCE-DEPENDENT will highlight some of these advances. Speakers will be asked to relate their MANNER discoveries to potential new strategies for disease control. Nilda E. Rodriguez, Upasna Gaur, Lee-Ann H. Allen, Mary E. Wilson CHAIR Veterans Affairs Medical Center and The University of Iowa, Iowa City, IA, United States Marcelo Jacobs-Lorena Johns Hopkins School of Public Health, Baltimore, MD, United States 1:30 p.m. MOSQUITO MICROBIOTA AND PLASMODIUM INFECTION George Dimopoulos Johns Hopkins School of Public Health, Baltimore, MD, United States

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1:55 p.m. 2 p.m. GENETICS OF PLASMODIUM FALCIPARUM-ANOPHELES 665 GAMBIAE INTERACTIONS Ken Vernick PREVALENCE OF PFDHFR AND PFDHPS HAPLOTYPES Institut Pasteur, Paris, France OF GENES ASSOCIATED WITH PLASMODIUM FALCIPARUM 2:20 p.m. RESISTANCE TO SULFADOXINE-PYRIMETHAMINE FROM ASYMPTOMATIC ISOLATES IN ANONKOUA- IDENTIFICATION OF TRANSCRIPTION FACTORS IN KOUTE (ABIDJAN, IVORY COAST) MALARIA SPOROZOITES Louis K. Penali1, Berenger A. Ako1, Offi anan A. Toure1, Marnie Briceno2, Masao Yuda Rokia Traore1, Carol H. Sibley2 Mie University, Mie, Japan 1Institut Pasteur de Cote d’Ivoire, Abidjan, Cote d’Ivoire, 2Genome Sciences Department, Seattle, WA, United States 2:45 p.m. (ACMCIP Abstract) GLYCOMIC AND GLYCO-PROTEOMIC INSIGHTS INTO PLASMODIUM TRANSMISSION BIOLOGY 2:15 p.m. Rhoel Dinglasan 666 Johns Hopkins School of Public Health, Baltimore, MD, United States BURDEN OF MALARIA IN PREGNANCY IN WOMEN Scientifi c Session 91 PRESENTING TO DELIVERY UNITS IN AREAS WITH STABLE AND UNSTABLE MALARIA TRANSMISSION IN Malaria - Epidemiology I CHHATTISGARH, INDIA Washington 3 Neeru Singh1, Mrigendra P. Singh2, Blair J. Wylie3, Manmohan M. Shukla2, Mobassir Hussain2, Aditya P. Dash4, Kojo Yeboah-Antwi5, Lora Sabin5, Friday, November 20, 1:30 p.m. - 3:15 p.m. Venkatachalam Udhayakumar6, Meghna Desai6, Davidson H. Hamer7 1 2 CHAIR Regional Medical Research Centre (ICMR), Jabalpur, India, National Institute for Malaria Research Field Station, Jabalpur, India, 3Massachusetts General Hospital, Frank Atuguba Boston, MA, United States, 4National Institute for Malaria Research, Delhi, India, Navrongo Health Research Centre, Navrongo, Ghana 5Center for International Health and Development, Boston University, Boston, MA, Louis Penali United States, 6Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Institute Pasteur, Abidjan, Cote d’Ivoire GA, United States, 7Center for International Health and Development, Boston, MA, United States 1:30 p.m. 2:30 p.m. 663 667 A RANDOMIZED CLINICAL TRIAL OF THE PROTECTIVE EFFICACY OF TRIMETHOPRIM-SULFAMETHOXAZOLE ROUTINE IRON SUPPLEMENTATION IN HIV-INFECTED PROPHYLAXIS AGAINST MALARIA IN HIV-EXPOSED PREGNANT WOMEN: IS IT ASSOCIATED WITH THE RISK CHILDREN OF MALARIA PARASITEMIA? 1 1 Taylor Sandison1, Jaco Homsy2, Emmanuel Arinaitwe3, Neil Vora4, Abel Atupele P. Kapito-Tembo , Steven R. Meshnick , Michaël B. van 2 2 3 4 Kakuru3, Humphrey Wanzira3, Victor Bigira3, Julius Kalamya2, Moses Hensbroek , Kamija S. Phiri , Margaret Fitzgerald , Terrie Taylor , Victor 5 Kamya5, Grant Dorsey4, Jordan Tappero6 Mwapasa 1 2 1University of Washington, Seattle, WA, United States, 2PMTCT Program, Centers for University of North Carolina-Chapel Hill, Chapel Hill, NC, United States, Malawi- Disease Control-Uganda, Entebbe, Uganda, 3Infectious Disease Research Collaboration, Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, 3 4 Kampala, Uganda, 4University of California, San Francisco, San Francisco, CA, United Malawi, Medecins San Frontieres (MSF)- Luxembourg, Thyolo, Malawi, Blantyre 5 States, 5Makerere University, Kampala, Uganda, 6Centers for Disease Control, Atlanta, Malaria Project, Blantyre, Malawi, Department of Community Health, College of GA, United States Medicine, Blantyre, Malawi 1:45 p.m. 2:45 p.m.

664 668

SEVERE DISEASE IN CHILDREN PACKAGE: IMPROVING USING DEMOGRAPHIC SURVEILLANCE SYSTEM CARE FOR CHILDREN WITH VERY SEVERE FEBRILE TO RECORD EARLY INADVERTENT EXPOSURE OF DISEASE PRESENTING TO FIRST-LEVEL HEALTH ANTIMALARIAL DURING PREGNANCY FACILITIES IN TANZANIA Abdunoor M. Kabanywanyi1, Aggrey Malila,2, Mathew Alexander2, Honesta Mzyangizyangi2, Honorati Masanja1, Salim Abdulla1 Jacek Skarbinski1, Thomas Lyimo2, Faustin Rwebogora2, Peter McElroy1, 1Ifakara Health Institute, Dar es Salaam, United Republic of Tanzania, 2Ifakara Health Salim Abdulla2, S. Patrick Kachur1, Elizeus Kahigwa2 Institute, Ifakara, United Republic of Tanzania 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Ifakara Health Institute, Dar es Salaam, United Republic of Tanzania

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3 p.m. 2:15 p.m.

669 673

LOW BIRTH WEIGHT, ILLNESS, AND DEATH AMONG BRUGIA MALAYI GENE EXPRESSION IN RESPONSE YOUNG CHILDREN OF THE KASSENA-NANAKANA TO TARGETED ELIMINATION OF THE WOLBACHIA DISTRICT OF NORTHERN GHANA: WHO, WHERE, ENDOSYMBIONT WHEN, AND SOMETIMES, WHY? Sara Lustigman1, Tiruneh Hailemariam1, Jay DePasse2, Xu Zhang2, Yelena Frank Atuguba1, David J. Fryauff2, Kwadwo A. Koram3, Thomas Oksov1, Thomas R. Unnasch3, Elodie Ghedin2 Anyorigiya1, Martin Adjuik1, Patrick Ansah1, Victor Asoala1, Abraham R. 1New York Blood Center, New York, NY, United States, 2University of Pittsburgh School Oduro1, Abraham Hodgson1, Lucas Amenga Etego1, Francis Nkrumah4 of Medicine, Pittsburgh, PA, United States, 3University of South Florida, Tampa, FL, 1Navrongo Health Research Center, Navrongo, Ghana, 2Naval Medical Research Center, United States Silver Spring, MD, United States, 3Noguchi Memorial Institute of Medical Research, (ACMCIP Abstract) Accra, Ghana, 4Navrongo Health Research Center, Accra, Ghana 2:30 p.m.

Scientifi c Session 93 674

Filariasis - Molecular Biology LATERAL GENE TRANSFER IN THE FILARIAL Washington 5 NEMATODES ONCHOCERCA FLEXUOSA AND Friday, November 20, 1:30 p.m. - 3:15 p.m. ACANTHOCHEILONEMA VITEAE CREATES NOVEL TRANSCRIPTS CHAIR Samantha N. McNulty1, Jeremy M. Foster2, Makedonka Mitreva1, John Sara Lustigman Martin1, Julie C. Dunning-Hotopp3, Norbert W. Brattig4, Barton E. Slatko5, New York Blood Center, New York, NY, United States Gary J. Weil1, Peter U. Fischer1, Bo Wu2 1Washington University School of Medicine, St. Louis, MO, United States, 2New England Helton C. Santiago Biolabs, Inc., Ipswich, MA, United States, 3University of Maryland School of Medicine, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD, United States, 4Bernhard Nocht Institute for Tropical Medicine, Bethesda, MD, United States Hamburg, Germany, 5New England Biolabs, Inc., Ipswich, MD, United States 1:30 p.m. 2:45 p.m.

670 675

STAGE-SPECIFIC MOLECULAR DETECTION OF EXPERIMENTAL CONFIRMATION OF FUNCTIONAL WUCHERERIA BANCROFTI L3 LARVAE IN MOSQUITOES OPERONS IN BRUGIA MALAYI Sandra J. Laney1, Reda M. Ramzy2, Hanan H. Helmy3, Hoda A. Farid3, Canhui Liu1, Ana deOliveira2, Elodie Ghedin3, Mutende Sikuyayenga2, Ameen Ashour3, Gary J. Weil4, Steven A. Williams5 Thomas R. Unnasch1 1Smith College/Ain Shams University, Northampton, MA, United States, 2Egyptian 1GHIDR Program, University of South Florida, Tampa, FL, United States, 2Division of Ministry of Health and Population, Cairo, Egypt, 3Ain Shams University, Cairo, Egypt, Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, United 4Washington University, St. Louis, MO, United States, 5Smith College/University of States, 3Division of Infectious Diseases, University of Pittsburgh School of Medicine, Massachusetts, Northampton, MA, United States Pittsburgh, PA, United States (ACMCIP Abstract) Friday, November 20 1:45 p.m. Exhibit Hall Open 671 Exhibit Hall A Friday, November 20, 3 p.m. - 4 p.m. THE TRANSCRIPTOME OF LOA LOA L3 INFECTIVE LARVAE IN COMPARISON TO THE L3 TRANSCRIPTOMES Coffee Break OF THE OTHER MAJOR HUMAN PATHOGENIC Exhibit Hall A FILARIAE Friday, November 20, 3:15 p.m. - 3:45 p.m. Doran L. Fink, Amy Klion, Thomas B. Nutman National Institutes of Health, Bethesda, MD, United States 2 p.m.

672

DECODING THE INVASION AND MOLTING PROCESSES OF BRUGIA MALAYI L3 LARVAE Sasisekhar Bennuru, Thomas B. Nutman National Institutes of Health, Bethesda, MD, United States

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Symposium 94 4:10 p.m. TRAVELERS’ VACCINE UPDATE FROM THE CENTERS Attenuated Whole Organism Sporozoite Vaccines for FOR DISEASE CONTROL AND PREVENTION Malaria Gary Brunette Centers for Disease Control and Prevention, Atlanta, GA, United States Salon 1 Friday, November 20, 3:45 p.m. - 5:30 p.m. 4:35 p.m. TRIBUTE TO JOHN DICK FLEMING MACLEAN, MD, Immunization with live attenuated sporozoites results in immune responses which generate protection against virulent sporozoites in rodent models of FRCPC, MRCP (UK), DCMT (LOND.) malaria and human volunteers. The symposium will present the current status Brian J. Ward on the development and optimization of live attenuated sporozoite vaccines Infectious Diseases, McGill University, Montreal, QC, Canada and the host responses that generate protective immunity to liver stage Michael Libman infection. McGill University, Toronto, ON, Canada CHAIR 5 p.m. Robert Sauerwein CLINICAL GROUP ANNUAL BUSINESS MEETING UMC Nijmegen, Nijmegen, The Netherlands Joseph M. Vinetz Ashley Birkett University of California at San Diego, La Jolla, CA, United States PATH Malaria Vaccine Initiative, Bethesda, MD, United States 3:45 p.m. Symposium 96 THE ROLE OF IMMUNOMICS American Committee on Arthropod-Borne Viruses (ACAV) Denise Doolan Queensland Institute of Medical Research, Brisbane, Australia II: ACAV 50th Anniversary Symposium: The Historical Role of ACAV in Virus Discovery, Epidemiology and 4:10 p.m. Prevention PROGRESS TOWARDS A GENETICALLY ATTENUATED Salon 3 PLASMODIUM SPOROZOITE VACCINE Friday, November 20, 3:45 p.m. - 5:30 p.m. Shahid Khan UMC Leiden, Leiden, The Netherlands The American Committee on Arthropod-Borne Viruses was founded 50 years ago to provide a forum for exchange of information among people 4:35 p.m. interested in arbovirus research. Because of the activities of ACAV, numerous PROGRESS IN DEVELOPING A GENETICALLY outstanding scientifi c contributions to arbovirology and tropical medicine ATTENUATED PARASITE (GAP) MALARIA VACCINE were accomplished. The symposium will describe the formation and history of ACAV and demonstrate how this network of dedicated scientists advanced Stefan Kappe research and our knowledge in areas including the invertebrate-transmitted Seattle Biomedical Research Institute, Seattle, WA, United States hemorrhagic fevers and California serogroup viruses. 5 p.m. CHAIR THE PFSPZ VACCINE: CHALLENGES IN MOVING FROM Charles Calisher PHASE 1 CLINICAL TRIALS TO LICENSURE Colorado State University, Fort Collins, CO, United States Steve Hoffman Sanaria Inc., Rockville, MD, United States 3:45 p.m. THE FOUNDING AND ORGANIZATION OF ACAV: Symposium 95 FORMATION OF A COMMUNITY Charles Calisher Clinical Group II Colorado State University, Fort Collins, CO, United States Salon 2 4:05 p.m. Friday, November 20, 3:45 p.m. - 5:30 p.m. COEVOLUTION OF ARBOVIROLOGY AND ACAV: This session features a malaria drug update and travel vaccine update. SYNERGY AND WORLDWIDE GROWTH Thomas Yuill CHAIR University of Wisconsin, Madison, United States Joseph M. Vinetz University of California at San Diego, La Jolla, CA, United States 4:25 p.m. YELLOW FEVER: THE ACAV NEXUS 3:45 p.m. Thomas P. Monath UPDATE ON MALARIA PROPHYLAXIS AND TREATMENT Kleiner Perkins Caufi eld & Byers, Harvard, MA, United States FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION Paul Arguin Centers for Disease Control and Prevention, Atlanta, GA, United States

152 ASTMH 58th Annual Meeting www.astmh.org

4:45 p.m. 4:25 p.m. CALIFORNIA SEROGROUP VIRUSES: ACAV AS MENTOR UGANDA: BUILDING NTD PROGRAMS ON A CHILD Don McLean HEALTH DAYS PLATFORM University of British Columbia, Vancouver, Canada Ambrose Onapa RTI International, Kampala, Uganda 5:05 p.m. HEMORRHAGIC FEVERS, HIGH HAZARD PATHOGEN 4:45 p.m. RESEARCH AND ACAV: A BRIEF HISTORY SIERRA LEONE: BUILDING NTD PROGRAMS ON AN Tom Ksiazek APOC PLATFORM University of Texas Medical Branch, Galveston, United States Joseph B. Koroma National Programme for the Control of Neglected Tropical Diseases, Ministry of Health Symposium 97 and Sanitation (MOHS), Freetown, Sierra Leone 5:10 p.m. Out of the Shadows: Integrated Efforts to Target the Neglected Tropical Diseases (NTDs) CLIMATE CHANGE IN NTD FUNDING: THE ROLE OF THE U.S. GOVERNMENT IN EXPANDING ACCESS TO Delaware A NTD CONTROL IN PARTNERSHIP WITH DISEASE- Friday, November 20, 3:45 p.m. - 5:30 p.m. ENDEMIC COUNTRIES, THE PRIVATE SECTOR AND INTERNATIONAL COMMUNITY Causing an unrelieved drain on the lives, health and economies of the world’s Christy Hanson poorest populations, the 13 diseases identifi ed by WHO as Neglected Tropical United States Agency for International Development, Washington, DC, United States Diseases (NTDs) have fi nally, during the past fi ve years, received deserved public attention and a legitimacy in discussions of global health policy. Essential to this attitudinal shift have been, fi rst, the recognition that seven of Symposium 98 these diseases can be effectively controlled or eliminated with agreed strategies and with tools often available at minimal or no cost because of generous A Winning Team: The Success of the Walter Reed Army donations by the pharmaceutical industry. Second, a focusing by WHO on Institute of Research and Its International Partnerships in opportunities for signifi cant resource optimization and health gains through integrated NTD control; and, fi nally, major funding commitments, fi rst by Advancing Vaccines for Malaria, HIV, Diarrheal Diseases the U.S. Congress (through USAID) and then by the U.K. government and Dengue Fever (through DFID), the Bill and Melinda Gates Foundation and others to support integrated efforts to control or eliminate these NTDs. Not all Delaware B countries have taken the same approach to integrating NTD control activities. Friday, November 20, 3:45 p.m. - 5:30 p.m. Each country has built its program on an appropriate, existing healthcare platform, aimed at achieving sustainable, cost-effective disease elimination or Walter Reed Army Institute of Research (WRAIR) investigators and their control. Quantifi able successes have been rapidly achieved. In 2008 the U.S. international partners will present practical examples of advances in vaccine government announced an initiative to expand its commitment to integrated development to counter the signifi cant endemic diseases of malaria, HIV, NTD control, aiming to provide one billion treatments in 30 countries by 2013. diarrheal diseases and dengue fever. The presentations will emphasize U.S. President Obama has included NTDs among his global health priorities. tangible solutions to the challenges of executing successful clinical trials in The purpose of this symposium is to provide country-specifi c experience international settings to include: investment in infrastructure and research with integrated approaches to NTD control and to identify opportunities capabilities, cross-training and technology transfer, community and cultural that must be pursued to promote the continued success of NTD control perspectives, ethical and regulatory challenges and the effi cient leveraging of programs everywhere and to expand the health improvements and poverty funding during a period of declining research funding, using current clinical Friday, November 20 reduction resulting from the investments already made by the partnership of trials as examples. Presentations will address the integration of research with governments, international agencies and the private sector. prevention, care and treatment programs, such as the President’s Emergency Program for AIDS Relief. The symposium will link advances in the research CHAIR laboratories, both at the WRAIR and at its overseas laboratories, and will Eric A. Ottesen address the challenges and rewards of translating these vaccine research Task Force for Global Health, Decatur, GA, United States efforts to the fi eld. Mary E. Linehan CHAIR RTI International, Washington, DC, United States Mark E. Polhemus 3:45 p.m. Walter Reed Army Institute of Research, Silver Spring, MD, United States NEGLECTED TROPICAL DISEASES (NTDS): Douglas N. Shaffer United States Army Research Unit-Kenya, Kericho, Kenya YESTERDAY’S DRAIN, TOMORROW’S GAIN FOR GLOBAL HEALTH 3:45 p.m. Lorenzo Savioli CRITERIA FOR ADVANCING MALARIA VACCINE World Health Organization, Geneva, Switzerland CANDIDATES FROM THE U.S. TO THE FIELD 4:05 p.m. Chris F. Ockenhouse Walter Reed Army Institute of Research, Silver Spring, MD, United States PARTNERING TO ACHIEVE A COMPREHENSIVE, COST- EFFECTIVE APPROACH TO THE NTDS Eric A. Ottesen Task Force for Global Health, Decatur, GA, United States

153 www.astmh.org Detailed Program

4:10 p.m. Symposium 100 CREATING A PREMIER INTERNATIONAL HIV VACCINE RESEARCH EFFORT BY LEVERAGED HORIZONTAL AND Understanding More about the Antimalarials Market in VERTICAL INTEGRATION Africa: Progress in a New Field of Research Nelson F. Michael Walter Reed Army Institute of Research, Rockville, MD, United States Washington 1 Friday, November 20, 3:45 p.m. - 5:30 p.m. 4:35 p.m. In 2008, the ASTMH meeting examined for the fi rst time the link between ESTABLISHING INTEGRATED PARTNERSHIPS IN EGYPT, understanding the antimalarials market and implications of such information PERU AND KENYA TO DESIGN, DEVELOP AND TEST to guide public health initiatives focused on the uptake of ACTs. Participants VACCINES AGAINST THE COMMON BACTERIAL CAUSES learned of early attempts to measure the antimalarials market in several OF DIARRHEA AND DYSENTERY African countries, and the way in which policymakers could use such data. Since then, the fi eld of market intelligence has expanded, with the early Robert Bowden Walter Reed Army Institute of Research, Silver Spring, MD, United States initiatives of 2008 now bearing fruit. The need for market data to guide public health initiatives is more pressing than ever. The Affordable Medicines 5 p.m. Facility, malaria (AMFm) has been approved for a pilot in 11 countries. GFATM funding to scale up access to ACTs has reached new highs. And yet KAMPHAENG-PHET, THAILAND: A MULTI-FACETED, we still have little information about the size and structure of the market. Who LONG-TERM COLLABORATION TO DEVELOP A still turns to the private sector to purchase an antimalarial medicine, what PREMIER FIELD SITE FOR SCIENTIFIC ADVANCEMENT do they receive, at what cost? This symposium will present the results of 12 AND CLINICAL TRIALS months of research, leading to a signifi cant improvement in our understanding of the market size, structure and the ways in which such information can guide In-Kyu Yoon ACT access and public health investments. This symposium will describe Armed Forces Research Institute of Medical Sciences/Walter Reed Army Institute of new data on the process and delays in public sector procurement of ACTs; Research, Bangkok, Thailand groundbreaking ways to measure the size and change in the market structure; and country-specifi c work concerning the affordability and availability of Symposium 99 antimalarial medicines. This range of initiatives starts to build a picture of the market, which can improve demand forecasting for needs, to target additional Getting the Most out of Bioinformatics Resources - ACT distribution opportunities in the public and private sectors, to measure Introduction to Resources That Can Facilitate Your Research the change in the market structure as the AMFm replaces older classes of drugs with ACTs. Such information is relevant to policymakers at the global Virginia AB level, as well as those working at national and sub-national level, making sure each caregiver has access to the most effective possible treatment available, at Friday, November 20, 3:45 p.m. - 5:30 p.m. all points of delivery. Bioinformatics, in particular organism-specifi c and comparative genomic CHAIR databases, are becoming increasingly available for a large number of organisms of interest to tropical disease researchers. The databases contain data ranging Renia Coghlan from genome sequences and the geographic locations of isolates, to tools Medicines for Malaria Venture, Geneva, Switzerland designed to help identify drug and vaccine targets. This session is designed as Eusebio Macete an introduction to several key resources, the data they contain and examples of CISM, Manhica, Mozambique how the tools they provide can facilitate both wet bench and fi eld research. 3:45 p.m. CHAIR AMFM: WHAT DO WE NEED TO KNOW ABOUT THE Jessica C. Kissinger MARKET, AND WHY? University of Georgia, Athens, GA, United States Serge Xueref 3:45 p.m. Global Fund for HIV/AIDS, TB and Malaria, Geneva, Switzerland SCHISTODB: SCHISTOSOMA MANSONI GENOME 4:10 p.m. EXPLORATION THE ANTIMALARIALS MARKET REALITY: PRICE AND Guilherme C. Oliveira AFFORDABILITY OF ANTIMALARIALS IN MALAWI Centro de Pesquisas René Rachou - FIOCRUZ, Belo Horizonte, Brazil Storn Kabuluzi 4:20 p.m. Ministry of Health, Malawi, Lilongwe, Malawi TARGET-BASED DRUG DEVELOPMENT: FROM 4:35 p.m. DATABASE PRIORITIZATION TO VALIDATION TO MINING DATABASES: WHAT DO WE KNOW ABOUT STRUCTURE BASED DRUG DEVELOPMENT PROCUREMENT DATA? Wesley C. Van Voorhis University of Washington, Seattle, WA, United States Brenda Waning Boston University, Boston, MA, United States 4:55 p.m. 5 p.m. EUPATHDB: A PROTIST PATHOGEN DATABASE FOR GATHERING MARKET DATA FROM THE TOP: IMS APICOMPLEXANS, KINETOPLASTIDS, GIARDIA AND HEALTH WORK ON MEASURING MARKET SIZE TRICHOMONAS Peter Stephens Jessica C. Kissinger IMS Health, London, United Kingdom University of Georgia, Athens, GA, United States

154 ASTMH 58th Annual Meeting www.astmh.org

Symposium 101 CHAIR Wilbur K. Milhous Anopheles Immunity to Plasmodium University of South Florida, Tampa, FL, United States Christine L. Moe Washington 2 Emory University, Atlanta, GA, United States Friday, November 20, 3:45 p.m. - 5:30 p.m. 3:45 p.m. The past decade has experienced a dramatic proliferation of our knowledge A MULTIDISCIPLINARY APPROACH IN WATER AND on the molecular biology of the malaria vector Anopheles gambiae. This SANITATION INTERVENTIONS symposium will address the latest breakthroughs and discoveries on genes and mechanisms that are implicated in defending the Anopheles mosquito against Linda Whiteford Plasmodium infection. University of South Florida, Tampa, FL, United States

CHAIR 4:10 p.m. George Dimopoulos DRY SANITATION AS WATER SAVING STRATEGY Johns Hopkins School of Public Health, Baltimore, MD, United States Ricardo Izurieta University of South Florida, Tampa, FL, United States 3:45 p.m. CAN THE MOSQUITO IMMUNE SYSTEM LEARN FROM 4:35 p.m. EXPERIENCE? WASTE WATER REUSE IN DEVELOPING COUNTRIES: Carolina Barillas-Mury THE DEVELOPMENT OF THE RECYCLED-TIRE SMALL National Institutes of Health, Bethesda, MD, United States BIOREACTOR AS STRATEGY FOR WASTE WATER REUSE IN DEVELOPING COUNTRIES 4:10 p.m. Daniel Yeh GENETIC VARIATION OF PLASMODIUM RESISTANCE University of South Florida, Tampa, FL, United States LOCI IN ANOPHELES GAMBIAE 5 p.m. Ken Vernick Institut Pasteur, Paris, France THE USE OF CACTUS MUCILAGE AS STRATEGY TO SCOUR ARSENIC AND BACTERIA IN WATER 4:35 p.m. Norma Alcantar MOSQUITO MECHANISMS OF DEFENSE AGAINST University of South Florida, Tampa, FL, United States MALARIA PARASITES George Christophides Symposium 103 Imperial College London, London, United Kingdom Drug Discovery for Human Helminthiases: From Genes to 5 p.m. Screens and Lessons from the Animal Health Sector IMMUNE PATHWAY REGULATED REFRACTORINESS TO PLASMODIUM Washington 4 George Dimopoulos Friday, November 20, 3:45 p.m. - 5:30 p.m. Johns Hopkins School of Public Health, Baltimore, MD, United States Schistosomiasis treatment and community-based morbidity control relies on just one drug, praziquantel. The dependency on a single drug is not Friday, November 20 Symposium 102 sustainable with concern about the evolution and spread of drug resistance. Hence, alternative drugs are urgently needed. This symposium reviews some Strategies for Water and Sanitation: A Multidisciplinary of the key advances in drug discovery approaches for neglected diseases, with Approach for Sustainable Communities a focus on helminth infections, not least the lessons learned from the animal health industry on what makes a good drug. Washington 3 Friday, November 20, 3:45 p.m. - 5:30 p.m. CHAIR David Williams The symposium is intended for health professionals, social scientists, engineers Rush University Medical Center, Chicago, IL, United States and other planners, or anyone with an interest in addressing critical shortages Conor Caffrey and health problems associated with inadequate and unsanitary water University of California San Francisco, San Francisco, CA, United States throughout the world. The symposium is designed to discus new strategies to overcome the barriers to provide water and sanitation in low-resource 3:45 p.m. countries. Adequate technologies for water treatment, waste water recycling and sanitation will be evaluated within the broader context of the earth’s CURRENT AND PROSPECTIVE NEEDS FOR environment, particularly from a sustainability perspective; the role of water PRAZIQUANTEL FOR THE CONTROL OF NEGLECTED as a crucial component to global health; and the cultural dimensions of local TROPICAL DISEASES and global health. As a result, the symposium will be highly interdisciplinary Lester Chitsulo and aims to share the information necessary to address complex problems World Health Organization, Geneva, Switzerland associated with water, sanitation, sustainability and health impacts to form teams that bring together many specialties.

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4:10 p.m. 4:15 p.m. IDENTIFICATION AND VALIDATION OF TARGETS FOR 678 ANTHELMINTIC DISCOVERY Tim Geary ASSESSMENT OF TWO MALARIA RAPID DIAGNOSTIC McGill University, Montreal, Canada TESTS, WITH FOLLOW-UP OF POSITIVE PLDH TEST 4:35 p.m. RESULTS, IN A HYPERENDEMIC FALCIPARUM MALARIA AREA THE USE OF SMALL MOLECULE TOOLS AND 1 2 2 3 SCREENING TECHNOLOGIES FOR NEGLECTED Sibylle Gerstl , Sophie Dunkley , Ahmed Mukhtar , Martin De Smet , Samuel Baker4, Jacob Maikere3 TROPICAL DISEASES 1Médecins Sans Frontières UK, London, United Kingdom, 2Médecins Sans Frontières Christopher Austin Brussels, Bo, Sierra Leone, 3Médecins Sans Frontières Brussels, Brussels, Belgium, National Institutes of Health Chemical Genomics Center, Bethesda, MD, United States 4Ministry of Health and Sanitation, Freetown, Sierra Leone 5 p.m. 4:30 p.m. DISCOVERY OF NEW ANTHELMINTICS FOR HUMANS: 679 LESSONS FROM THE VETERINARY SIDE Debra Woods MISDIAGNOSIS AND OVERTREATMENT OF CLINICAL Pfi zer Animal Health, Kalamazoo, MI, United States MALARIA CASES AND THEIR IMPLICATIONS IN WESTERN KENYA HIGHLANDS Yaw A. Afrane1, Andrew Githeko1, Guiyun Yan2 Scientifi c Session 104 1Kenya Medical Research Institute, Kisumu, Kenya, 2Program in Public Health, University of California, Irvine, Irvine, CA, United States Malaria - Diagnosis 4:45 p.m.

Washington 5 680 Friday, November 20, 3:45 p.m. - 5:30 p.m. QUALITY CONTROL OF MALARIA SLIDE DENSITIES CHAIR Neal Alexander1, David Schellenberg1, Billy Ngasala2, Max Petzold3, Chris Neal Alexander Drakeley1, Colin Sutherland1 London School of Hygiene and Tropical Medicine, London, United Kingdom 1London School of Hygiene and Tropical Medicine, London, United Kingdom, 2Karolinska Meredith McMorrow Institute, Stockholm, Sweden, 3Nordic School of Public Health, Gothenburg, Sweden Centers for Disease Control and Prevention, Atlanta, GA, United States 5 p.m. 3:45 p.m. 681 676 A HIGH-THROUGHPUT POOLING AND TESTING HIGH SENSITIVITY OF RAPID DIAGNOSTIC TESTS STRATEGY FOR PCR DETECTION AND SPECIATION OF FOR MALARIA IN ROUTINE PATIENT CARE IN RURAL MALARIA DURING PREGNANCY IN KINSHASA TANZANIA Steve M. Taylor1, Jonathan J. Juliano2, Paul A. Trottman1, Travis A. Meredith McMorrow1, Irene Masanja2, Elizeus Kahigwa2, Salim M. Abdulla2, Thompson1, Jennifer B. Griffi n1, Sarah H. Landis1, Paluku Kitsa3, Antoinette S. Patrick Kachur1 Tshefu3, Steven R. Meshnick1 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Ifakara 1Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, Health Institute, Dar es Salaam, United Republic of Tanzania United States, 2Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC, United States, 3Kinshasa School of Public Health, Kinshasa, The Democratic 4 p.m. Republic of the Congo

677 5:15 p.m.

A SYSTEMATIC REVIEW OF THE ACCURACY OF RAPID 682 DIAGNOSTIC TESTS FOR MALARIA IN ENDEMIC AREAS Piero Olliaro HIGH THROUGHPUT QUANTITATIVE MULTIPLEX 5’ World Health Organization, Geneva, Switzerland NUCLEASE PCR ASSAY FOR DIAGNOSIS AND CLINICAL INVESTIGATION OF MALARIA Emily G. Clemens, Megan E. Reller, Karen C. Carroll, J. Stephen Dumler The Johns Hopkins University School of Medicine, Baltimore, MD, United States

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Plenary Session 105 Saturday, November 21

Plenary Session III: Commemorative Fund Lecture Registration Salon 2 Salon Foyer Friday, November 20, 6 p.m. - 6:45 p.m. Saturday, November 21, 7 a.m. - 5 p.m.

The ASTMH Commemorative Fund Lecture is presented annually by an Cyber Cafe invited senior researcher in the tropics. Marriott Foyer CHAIR Saturday, November 21, 7 a.m. - 5 p.m. Thomas E. Wellems Speaker Ready Room ASTMH President, Rockville, MD, United States PAST VALUE AND NEW POTENTIAL OF DEMOGRAPHIC Maryland A SURVEILLANCE SYSTEMS IN DEVELOPING COUNTRIES Saturday, November 21, 7 a.m. - 6 p.m. Fred Binka Scientifi c Program Committee Meeting University of Ghana, Accra, Ghana Balcony B Poster Session B Dismantle Saturday, November 21, 7 a.m. - 8 a.m. Web Site Committee Meeting Exhibit Hall B South Friday, November 20, 7 p.m. - 8 p.m. Room 8217 Saturday, November 21, 7 a.m. - 8 a.m. Symposium 106 ASTMH Past Presidents Meeting

Malaria Genomics and Postgenomics Update Balcony C Saturday, November 21, 7 a.m. - 8 a.m. Supported with funding from the Burroughs Wellcome Fund Media Room Salon 3 Friday, November 20, 7:15 p.m. - 9 p.m. Rooms 8228/8229 Saturday, November 21, 7:30 a.m. - 6 p.m. New fi ndings and project directions from the ongoing malaria sequencing, array and analysis projects. Symposium 107 CHAIR Victoria P. McGovern Central Role of Macrophages in Parasite Immunity Burroughs Wellcome Fund, Research Triangle Park, NC, United States Salon 1 7:15 p.m. Saturday, November 21, 8 a.m. - 9:45 a.m. UPDATE FROM SCRIPPS Macrophages display amazing fl exibility and can change their function in Elizabeth Winzeler response to a wide variety of environmental stimuli. These changes can give Scripps, San Diego, CA, United States rise to different subpopulations of macrophages with distinct functional 7:40 p.m. activities. Recent studies suggest that activated macrophages, conventionally associated with IFN-Γ-dominant Th1 responses to many bacteria and UPDATE FROM SEATTLE viruses, also play a central role in the Th2-type infl ammatory response. Patrick Duffy These macrophages are referred to as alternatively activated macrophages SBRI, Seattle, WA, United States (AAMs) as they express a characteristic pattern of cell surface and secreted molecules distinct from that of classically activated macrophages (CAMs). The 8:05 p.m. conservation of underlying common mechanisms of macrophage activation and subsequent control forms the overall thematic organization of this mini- UPDATE FROM NATIONAL INSTITUTES OF HEALTH symposium. The speakers will discuss recent fi ndings regarding the role of Xinzhuan Su macrophage sub-populations in the development of disease and host protection National Institutes of Health, Bethesda, MD, United States following infection with both protozoan and helminthic parasites. Saturday, November 21

8:30 p.m. CHAIR UPDATE FROM SANGER Thomas A. Wynn Dominic Kwiatkowski National Institutes of Health, Bethesda, MD, United States Sanger Centre, Cambridge, United Kingdom 8 a.m. HELMINTH-ELICITED MACROPHAGES IN TH2- MEDIATED INFLAMMATION Judi Allen University of Edinburgh, Edinburgh, United Kingdom

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8:25 a.m. 8:50 a.m. ROLE OF ALTERNATIVELY-ACTIVATED MACROPHAGES HIGH SPATIAL RESOLUTION ENDEMICITY MAPPING IN IN IMMUNITY TO INTESTINAL NEMATODES KENYA William C. Gause Abdisalan M. Noor University of Medicine and Dentistry of New Jersey, Newark, NJ, United States Kenya Medical Research Institute (KEMRI), Nairobi, Kenya 8:50 a.m. 9:15 a.m. EXPLORING THE FULL SPECTRUM OF MACROPHAGE THE GLOBAL SPATIAL LIMIT AND INTENSITY OF P. ACTIVATION DURING INFECTION VIVAX TRANSMISSION David M. Mosser Carlos A. Guerra University of Maryland, College Park, MD, United States Oxford University, Oxford, United Kingdom 9:15 a.m. Symposium 109 ROLE OF ALTERNATIVELY-ACTIVATED MACROPHAGES IN CHRONIC HELMINTH INFECTION Call 4 Action: Use of Mobile Phone Technologies for the Thomas A. Wynn Improvement of Human Health National Institutes of Health, Bethesda, MD, United States Salon 3 Symposium 108 Saturday, November 21, 8 a.m. - 9:45 a.m.

Mobile phones are widely used and are means for new communication The Global Distribution of Plasmodium falciparum Malaria technologies applied to human health issues. They could be used as ways to in 2007 link people for civil actions, help public health offi cials to implement programs, be incorporated into programs to educate the public, etc. Especially useful Salon 2 in prevention of death rates, containment of epidemics and prevention of Saturday, November 21, 8 a.m. - 9:45 a.m. communicable diseases, mobile technologies may represent potential benefi ts to users. This symposium will present specifi c examples by which the use of A global evidence-based distribution map describing Plasmodium falciparum cell phones has shown to be an effective tool, and data will be presented on endemicity in 2007 has been published by the Malaria Atlas Project (http:// ongoing specifi c projects. This symposium aims to show how interdisciplinary www.map.ox.ac.uk). In addition, an open access database of the contributing solutions could make signifi cant differences in the future of global health. parasite rate surveys has also recently been released under a creative commons Experts in the fi elds of global health, civil action and medical epidemiology license. This symposium will give an overview of the 2007 P. falciparum will each present an example of the use of mobile technology in the developing map and include brief navigation of the database. The scientifi c advances world. and statistical techniques that were required to create this map will also be detailed. Data continues to be accumulated by the Malaria Atlas Project so CHAIR that more than 14,000 surveys will contribute to the 2008 iteration of the Irene Bosch P. falciparum map. The methodological underpinnings also continue to be University of Massachusetts Medical School, Worcester, MA, United States developed at the national level and this is explored with the country example of endemicity mapping in Kenya. Finally, these techniques are also being Martin Lajous extended to P. vivax and preliminary results of a global spatial limits and Harvard School of Public Health, Boston, MA, United States intensity of its transmission is presented. 8 a.m. CHAIR CELL PHONES AS A TOOL FOR COMMUNITY ACTIONS David L. Smith Christopher Csikszentmihályi University of Florida, Gainesville, FL, United States Massachusetts Institute of Technology, Cambridge, MA, United States Simon I. Hay Kenya Medical Research Institute and Department of Zoology, University of Oxford, 8:25 a.m. Nairobi, Kenya OPEN MOBILE CONSORTIUM: WHO WE ARE AND WHAT 8 a.m. WE DO Kirkpatrick Robert THE GLOBAL DISTRIBUTION OF P. FALCIPARUM Open Mobile Consortium, Cambridge, MA, United States MALARIA IN 2007 AND 2008 Simon I. Hay 8:50 a.m. Kenya Medical Research Institute and Department of Zoology, University of Oxford, MOBILE PHONE APPLICATIONS IN THE HEALTH Nairobi, Kenya PROJECTS 8:25 a.m. Daniel Carucci United Nations Foundation, Washington DC, United States BAYESIAN MODEL-BASED GEOSTATISTICS Peter W. Gething 9:15 a.m. Oxford University, Oxford, United Kingdom INFORMATION TECHNOLOGY TO PROMOTE GLOBAL HEALTH Anup Akkihal Logistics for Global Good, Inc., Washington DC, United States

158 ASTMH 58th Annual Meeting www.astmh.org

Scientifi c Session 110 9 a.m. 687 Viruses I Delaware A PREVENTING NIPAH VIRUS TRANSMISSION: Saturday, November 21, 8 a.m. - 9:45 a.m. UNDERSTANDING EFFICACY OF BAMBOO SKIRT TO IMPEDE DATE PALM SAP CONTAMINATION BY BATS CHAIR M. S. Khan1, Emily S. Gurley1, Md. Jahangir Hossain1, Nazmun Nahar1, Charles Calisher Stephen P. Luby2 Colorado State University, Fort Collins, CO, United States 1International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, 2 Sarah A. Ziegler Centers for Disease Control and Prevention, Atlanta, GA, United States University of Texas Medical Branch, Galveston, TX, United States 9:15 a.m. 8 a.m. 688 683 CHIKUNGUNYA VIRUS POPULATION DYNAMICS IN SARS CORONAVIRUS ADAPTATION TO HUMAN IS CELLS AND AEDES ALBOPICTUS PARTIALLY CONSTRAINED BY HOST ALTERATION Lark L. Coffey, Marco Vignuzzi Xianchun Tang1, Nikos Vasilakis2, Zhenli Shi3, Yang Zhong4, Lin-fa Wang5, Institut Pasteur, Paris, France Shuyi Zhang1 1School of Life Science, East China Normal University, Shanghai, China, 2Center for 9:30 a.m. Vaccine Research, University of Pittsburgh, Pittsburgh, PA, United States, 3Institute of Virology, Chinese Academy of Sciences, Wuhan, China, 4School of Life Sciences, Fudan 689 University, Shanghai, China, 5Australian Animal Health Laboratory and Australian Biosecurity Cooperative Research Centre, Geelong, Australia ISOLATION AND PHYLOGENETIC ANALYSIS OF MUCAMBO VIRUS (VENEZUELAN EQUINE 8:15 a.m. ENCEPHALITIS COMPLEX SUBTYPE IIIA) IN TRINIDAD 684 Auguste J. Auguste1, Sara Volk2, Nicole Arrigo2, Raymond Martinez1, Vernie Ramkissoon1, A. Paige Adams2, Abiodun Adesiyun1, Dave Chadee1, Jerome Foster1, Amelia Travassos Da Rosa2, Robert Tesh2, Scott Weaver2, Christine A COMPARISON OF THE PATHOGENESIS OF V. Carrington1 CHIKUNGUNYA VIRUS IN MICE AFTER INFECTION BY 1The University of the West Indies, St. Augustine, Trinidad and Tobago, 2University of MOSQUITO BITE OR NEEDLE INOCULATION Texas Medical Branch, Galveston, TX, United States Sarah A. Ziegler1, Dana Vanlandingham1, Amelia P. Travassos da Rosa1, Shu-Yuan Xiao2, Stephen Higgs1, Robert B. Tesh1 Symposium 111 1University of Texas Medical Branch, Galveston, TX, United States, 2Weill Cornell Medical College, New York, NY, United States Rapid Diagnostic Tools in Theory and Practice 8:30 a.m. Delaware B 685 Saturday, November 21, 8 a.m. - 9:45 a.m. There is an urgent need for simple, reliable and accurate diagnostics for IMMUNOGENICITY AND EFFICACY OF A NOVEL infectious diseases of public health importance in the developing world. RECOMBINANT VACCINE AGAINST ARGENTINE Improving existing tests and approaches and adopting new methods are HEMORRHAGIC FEVER integral to improving disease control and patient outcomes and curtailing drug resistance. However, even rapid diagnostic tests (RDTs), despite their Alexey Seregin, Nadezhda E. Yun, Milagros Salazar, Allison L. Poussard, Jennifer K. Smith, Jeanon N. Smith, Michele A. Zacks, Slobodan Paessler apparent simplicity, are not widely accessible, and due to the weak regulatory University of Texas Medical Branch, Galveston, TX, United States approval standards in most developing countries, the quality of diagnostics is not assured. Furthermore, even after independent, comprehensive 8:45 a.m. evaluation of performance, the adoption of these approaches and/or methods and acceptance into everyday practice poses a specifi c set of challenges. 686 This symposium aims to give an overview of the technical and operational performance of selected diagnostic methods, with special emphasis on rapid diagnostic tests (RDTs) for high burden diseases (TB, malaria and visceral MOLECULAR PHYLOGENY OF A NEWFOUND Saturday, November 21 leishmaniasis) and address the challenges and solutions to their adoption into HANTAVIRUS HARBORED BY THE EASTERN MOLE daily practice in endemic settings. (SCALOPUS AQUATICUS) Hae Ji Kang1, Shannon N. Bennett1, Laarni Sumibcay1, Andrew G. Hope2, CHAIR Jin-Won Song3, Joseph A. Cook2, Richard Yanagihara1 Jane Cunningham 1University of Hawaii, Honolulu, HI, United States, 2University of New Mexico, World Health Organization, Geneva, Switzerland Albuquerque, NM, United States, 3Korea University, Seoul, Republic of Korea Rosanna Peeling London School of Hygiene and Tropical Medicine, London, United Kingdom

159 www.astmh.org Detailed Program

8 a.m. 8:30 a.m. GETTING A RAPID TB DIAGNOSIS: WHAT CAN WE DO 692 WITH WHAT’S AVAILABLE? Luis Cuevas EFFECT OF CHALLENGE INFECTIONS ON THE IMMUNE World Health Organization, Geneva, Switzerland RESPONSE OF MICE PREVIOUSLY INFECTED WITH 8:25 a.m. TOXOCARA CANIS, TOXOPLASMA GONDII OR BOTH PARASITES PERFORMANCE AND QUALITY ASSURANCE OF 1 1 1 MALARIA RDTS: LESSONS FROM THE LAB AND THE Dwight D. Bowman , Benjamin R. Bralove , Tian Z. Liang , Janice L. Liotta1, Woraporn Sukhumavasi2, J. P. Dubey3 FIELD 1Cornell College of Veterinary Medicine, Ithaca, NY, United States, 2Chulalongkorn David Bell University, Bangkok, Thailand, 3USDA, Beltsville, MD, United States Foundation for Innovative New Diagnostics, Geneva, Switzerland (ACMCIP Abstract) 8:50 a.m. 8:45 a.m. EXPERIENCES ROLLING OUT RAPID DIAGNOSTICS FOR 693 VL ELIMINATION CAMPAIGN Suman Rijal APPLICATION OF A TRNA REPEAT UNIT GENOTYPING B.P Koirala Institute of Health Sciences, Dharan, Nepal METHOD TO CLINICAL ISOLATES OF ENTAMOEBA 9:15 a.m. HISTOLYTICA 1 2 1 INTEGRATING NEW DIAGNOSTIC TOOLS AND Krishna Khairnar , Irving Salit , Dylan R. Pillai 1Ontario Agency for Health Protection and Promotion, Toronto, ON, Canada, 2University APPROACHES AS PART OF A COMMUNITY-BASED CASE Health Network, Toronto, ON, Canada MANAGEMENT PACKAGE Caroline Asiimwe 9 a.m. Foundation for Innovative New Diagnostics, Kampala, Uganda 694 Scientifi c Session 112 ROLE OF NF-KB RESPONSES AND APOPTOSIS IN Protozoa MAINTAINING EPITHELIAL HOMEOSTASIS DURING ENTAMOEBA HISTOLYTICA INFECTION Virginia AB Stephen Becker, Kyou-Nam Cho, Eric R. Houpt Saturday, November 21, 8 a.m. - 9:45 a.m. University of Virginia, Charlottesville, VA, United States (ACMCIP Abstract) CHAIR Thaddeus Graczyk 9:15 a.m. Johns Hopkins University, Baltimore, MD, United States 695 Barbara Mann University of Virginia, Charlottesville, VA, United States HIGH DOSE OF VITAMIN A SUPPLEMENTATION 8 a.m. PROTECTS ABORIGINAL SCHOOLCHILDREN IN RURAL MALAYSIA FROM GIARDIA DUODENALIS REINFECTION: A 690 RANDOMIZED CONTROLLED TRIAL Hesham M. Al-Mekhlafi 1, Johari Surin1, Atiya A. Sallam1, Wan Ariffi n TRACKING TOXOPLASMA GONDII FROM LAND TO SEA Abdullah1, Mohammed A. Mahdy1, Che Abdullah Hassan2 Patricia A. Conrad1, Elizabeth VanWormer1, Karen Shapiro1, Melissa Miller2, 1University of Malaya, Kuala Lumpur, Malaysia, 2Ministry of Health, Putrajaya, Chris Kreuder-Johnson1, Tim Tinker3, Michael Grigg4, John Largier1, Tim Malaysia Carpenter1, Jonna K. Mazet1 1University of California, Davis, Davis, CA, United States, 2California Department of 9:30 a.m. Fish and Game, Santa Cruz, CA, United States, 3USGS-WERC, Santa Cruz, CA, United States, 4National Institutes of Allergy and Infectious Disease, Bethesda, MD, 696 United States LOW TEMPERATURE INDUCES TROPHOZOITES OF 8:15 a.m. ACANTHAMOEBA SPP. TO PHAGOCYTOSE FRANCISELLA 691 TULARENSIS, EXPLAINING A POSSIBLE MECHANISM OF SURVIVAL DURING WINTER PUBLIC HEALTH SAFETY OF RECREATIONAL BEACH James R. Palmieri, Shaadi F. Elswaifi WATERS Virginia College of Osteopathic Medicine, Blacksburg, VA, United States Thaddeus Graczyk1, Deirdre Sunderland1, Yessika Mashinski1, Frances Lucy2, Patrick Breysse1 1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 2Institute of Technology, Sligo, Ireland

160 ASTMH 58th Annual Meeting www.astmh.org

Scientifi c Session 113 9 a.m. 701 Schistosomiasis and Other Trematodes - Vectors and Vector Biology VARIATIONS WITHIN LOCI CORRESPONDING TO Virginia C HYDROLYTIC ENZYMES BETWEEN RESISTANT AND Saturday, November 21, 8 a.m. - 9:45 a.m. SUSCEPTIBLE BIOMPHALARIA GLABRATA SNAILS: EFFECTS OF SCHISTOSOMA MANSONI EXPOSURE AND CHAIR AGE OF SNAIL Matty Knight Jocelyn C. Myers1, Wannaporn Ittiprasert1, Andre Miller1, Matty Knight1, Biomedical Research Institute, Rockville, MD, United States Clarence M. Lee2 1 2 Sam Loker Biomedical Research Institute, Rockville, MD, United States, Howard University, University of New Mexico, Albuquerque, NM, United States Washington, DC, United States 8 a.m. 9:15 a.m.

697 702

MOLECULAR SIGNALING DURING THE MIRACIDIUM HUMAN FASCIOLIASIS IN LATIN AMERICA: THE TO SPOROCYST TRANSFORMATION IN SCHISTOSOMA ENDEMIC FOCI IN ANDEAN COUNTRIES AND MANSONI CARIBBEAN-CENTRAL AMERICA 1 2 3 4 Andrew S. Taft, Francesca Norante, Timothy P. Yoshino Santiago Mas-Coma , Rene Angles , Jose R. Espinoza , Valeria Gayo , 5 6 7 University of Wisconsin, Madison, Madison, WI, United States Carolina Gonzalez , Roberto Mera y Sierra , Lazara Rojas , Jose Lino Zumaquero-Rios8, Maria Dolores Bargues1 8:15 a.m. 1Departamento de Parasitologia, Universidad de Valencia, Burjassot - Valencia, Spain, 2Catedra de Parasitologia, Facultad de Medicina, Universidad Mayor de San Andres, 3 698 La Paz, Bolivia, Unidad de Biotecnologia Molecular, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru, 4Departamento de Parasitologia, Dilave, Ministerio de Ganaderia, Agricultura y Pesca, Montevideo, Uruguay, 5Catedra de DIFFERENTIAL GENE EXPRESSION IN BIOMPHALARIA Parasitologia, Facultad de Farmacia y Bioanalisis, Universidad de Los Andes, Merida, GLABRATA NEONATE SNAILS IN RESPONSE TO Venezuela, 6Area de Infectologia, Faultad de Ciencias Medicas, Universidad Nacional de SCHISTOSOMA MANSONI INFECTION Cuyo y Catedra de Parasitologia, Facultad de Ciencias Veterinarias, Universidad J.A. Mazza, Mendoza, Argentina, 7Instituto de Medicina Tropical Pedro Kouri, La Havana, Nithya Raghavan, Andre Miller, Fred Lewis, Matty Knight Cuba, 8Laboratorio de Parasitologia, Facultad de Biologia, Benemerita Universidad Biomedical Research Institute, Rockville, MD, United States Autonoma de Puebla, Puebla, Mexico 8:30 a.m. 9:30 a.m.

699 703

CHARACTERIZATION OF THE TRANSCRIPTIONAL ETIOLOGY AND EPIDEMIOLOGY OF CERCARIAL PROFILE OF BIOMPHALARIA GLABRATA AFTER DERMATITIS IN NORTH AMERICA BACTERIAL AND PARASITE CHALLENGE Sara V. Brant, Eric S. Loker Patrick C. Hanington, C. M. Adema, C. M. Lun, E. S. Loker University of New Mexico, Albuquerque, NM, United States Center for Evolutionary and Theoretical Immunology, University of New Mexico, Albuquerque, NM, United States (ACMCIP Abstract) Scientifi c Session 114

8:45 a.m. Neglected Tropical Diseases

700 Washington 1 Saturday, November 21, 8 a.m. - 9:45 a.m. DEVELOPMENT AND CHARACTERIZATION OF VARIABLE EST-SSR MARKERS DELINEATING CHAIR RESISTANCE/SUSCEPTIBILITY TO SCHISTOSOMA Peter Fischer MANSONI IN THE INTERMEDIATE SNAIL HOST, Washington University School of Medicine, St. Louis, MO, United States Saturday, November 21 BIOMPHALARIA GLABRATA Artemis Koukounari Imperial College, London, United Kingdom Wannaporn Ittiprasert, Andre’ Miller, Jocelyn Myers, Matty Knight Biomedical Research Institute, Rockville, MD, United States

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8 a.m. 9:15 a.m.

704 709

RESULTS FROM SENTINEL SITE SURVEILLANCE DIFFERENTIAL DECLINE OF HELMINTH INFECTIONS FOR TRACHOMA AND SCHISTOSOMIASIS BEFORE ON ALOR ISLAND, INDONESIA FOLLOWING SIX PREVENTIVE CHEMOTHERAPY IN BURKINA FASO ROUNDS OF MASS DRUG ADMINISTRATION USING Artemis Koukounari1, Seydou Toure2, Amadou Ouedraogo2, Bernadette DIETHYLCARBAMAZINE IN COMBINATION WITH B. Yoda3, Martin Kabore3, Elisa Bosque-Oliva1, Joanne P. Webster1, Alan ALBENDAZOLE 1 Fenwick 1 2 2 3 1 2 Peter U. Fischer , Yenny Djuardi , Heri Wibowo , Mark Bradley , Asmus Schistosomiasis Control Initiative, London, United Kingdom, Réseau International Hammerich4, Rahmah Noordin5, Taniawati Supali2 Schistosomiases Environnement Aménagements et Lutte, Ouagadougou, Burkina Faso, 1Washington University School of Medicine, St. Louis, MO, United States, 2Department 3 Programme National de Prevention de la Cecité, Ouagadougou, Burkina Faso Parasitology, University of Indonesia, Jakarta, Indonesia, 3Global Community Partnerships, GlaxoSmithKline, Brentfort, United Kingdom, 4GTZ/SISKES, Kupang, 8:15 a.m. Indonesia, 5Universiti Sains Malaysia, Penang, Malaysia 705 9:30 a.m.

PARASITOLOGICAL IMPACT OF ONE YEAR PREVENTIVE 710 MASS CHEMOTHERAPY ON SOIL-TRANSMITTED HELMINTHIASIS AND SCHISTOSOMIASIS IN PERCEPTIONS OF INTEGRATED NEGLECTED TROPICAL NORTHERN RWANDA DISEASE PROGRAMS AMONG MINISTRY OF HEALTH Karibushi Blaise1, Mupfasoni Denise1, Ruberanziza Eugene1, Sebeza STAFF IN MALI Jackson2, Mukabayire Odette3, Kabera Michee1, Kramer Michael2, Ruxin Sonia Pelletreau1, Jennifer Lasley1, Sory I. Bamba2, Massitan D. Soumare2, Josh4, Fenwick Alan5 Sanoussi Bamani2, Antandou Telly3, Els Mathieu1 1The Access Project, Kigali, Rwanda, 2Ministry of Health/Treatment Research Aids 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Ministry of Center Plus, Kigali, Rwanda, 3National Reference Laboratory, Kigali, Rwanda, 4The Health, Bamako, Mali, 3International Trachoma Initiative, Bamako, Mali Earth Institute, Columbia University, New York, NY, United States, 5Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom Symposium 115

8:30 a.m. Fetal Responses to Placental Malaria: The Forgotten Half

706 Washington 2 Saturday, November 21, 8 a.m. - 9:45 a.m. RANDOMISED CONTROLLED TRIALS (RCTS) OF PRAZIQUANTEL 40 VS. 60 MG/KG FOR TREATING The problem of malaria during pregnancy has received increasing attention in recent years, resulting in major advances in our understanding of the INTESTINAL SCHISTOSOMIASIS pathogenesis of malaria in both the expectant woman and her unborn baby. Piero L. Olliaro However, many questions remain. It is important to determine mechanisms World Health Organization, Geneva, Switzerland by which placental malaria results in placental damage, fetal compromise and poor neonatal outcomes. Some information on maternal and parasitic 8:45 a.m. contributions to the problem is available, but little is known about the contributions of the fetoplacental unit itself to placental malaria. This 707 symposium will summarize current efforts to assess the biochemical and immunological functions of the villous placenta in the context of malaria INTEGRATED CONTROL STRATEGIES OF infection, and how malaria-associated perturbations infl uence the fetoplacental SCHISTOSOMIASIS TRANSMISSION INFORMED BY A unit, birth outcome and infant responses to malaria. BAYESIAN MULTILEVEL MODEL AT A LOCAL SCALE CHAIR Kun Yang College of Public Health, The Ohio State University, Columbus, OH, United States Julie M. Moore University of Georgia, Athens, GA, United States 9 a.m. Diane W. Taylor University of Hawaii, Honolulu, HI, United States 708 8 a.m. EVALUATION OF INTEGRATED MASS DRUG THE CONTRIBUTION OF THE TROPHOBLAST TO ADMINISTRATIONS FOR NEGLECTED TROPICAL THE MATERNAL IMMUNE RESPONSE TO PLACENTAL DISEASES IN HAITI MALARIA Erin D. Kennedy1, Gabrielle Philius2, Abdel N. Direny3, Luccene Desir4, Julie M. Moore Jean-Francois Vely2, Thomas G. Streit4, Els Mathieu1 University of Georgia, Athens, GA, United States 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Ministry of Health, Port-au-Prince, Haiti, 3IMA World Health, Port-au-Prince, Haiti, 4University of Notre Dame, Notre Dame, IN, United States

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8:30 a.m. 8:30 a.m. PLACENTAL MALARIA AND TROPHOBLAST FUNCTION 713 Stephen Rogerson University of Melbourne, Melbourne, Australia IDENTIFICATION OF COLONIZATION FACTOR 8:55 a.m. ANTIGEN IN NON-ENTEROTOXIGENIC E. COLI STRAINS 1 2 1 2 MECHANISMS OF TRANSPLACENTAL TRANSFER OF Fulton P. Rivera , Maria Bernal , Theresa J. Ochoa , Rina Meza , Francesca Barletta1, Erik Mercado1, Maribel Riveros1, David Cepeda2, Ryan C. Maves2, MALARIAL ANTIGENS TO THE FETUS Eric R. Hall3, Ann-Mari Svennerholm4, Claudio F. Lanata5 Christopher L. King 1Universidad Peruana Cayetano Heredia, Lima, Peru, 2United States Naval Medical Case Western Reserve University, Cleveland, OH, United States Research Center Detachment, Lima, Peru, 3United States Naval Medical Research Center, Silver Spring, MD, United States, 4Göteburg University, Göteburg, Sweden, 9:20 a.m. 5Instituto de Investigacion Nutricional, Lima, Peru THE FETAL RESPONSE TO PLACENTAL MALARIA AND 8:45 a.m. IMPLICATIONS FOR THE INFANT Diane W. Taylor 714 University of Hawaii, Honolulu, HI, United States ANTI-TOXIN IMMUNITY IN ENTERIC DISEASE: Scientifi c Session 116 MAINTAINING THE INTEGRITY OF THE INNATE MUCOSAL BARRIER Bacteriology - Diarrhea, E. coli and Cholera Gregory M. Glenn, David Flyer, Diane Epperson, Jianmei Yu Intercell US, Gaithersburg, MD, United States Washington 3 Saturday, November 21, 8 a.m. - 9:45 a.m. 9 a.m.

CHAIR 715 Jean-Paul Chretien Walter Reed Army Institute of Research, Silver Spring, MD, United States CONCOMITANT INFECTION WITH VIBRIO CHOLERAE O1 Gregory M. Glenn AND ENTEROTOXIGENIC ESCHERICHIA COLI INDUCES Iomai Corporation, Gaithersburg, MD, United States A MORE ROBUST IMMUNE RESPONSE TO CHOLERA ANTIGENS 8 a.m. Fahima Chowdhury1, Yasmin Ara Begum1, Murshid Alam1, Ashraful 1 1 2 2 711 Islam Khan , Tanvir Ahmed , Regina C. LaRocque , Jason B. Harris , ASG Faruque1, Stephen B. Calderwood2, Edward T. Ryan2, Ann-Mari Svennerholm3, Firdausi Qadri1 IMPORTANCE OF VIRAL PATHOGENS IN EARLY 1International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, CHILDHOOD DIARRHEA IN RURAL AND URBAN NEPAL 2Massachusetts General Hospital, Boston, MA, United States, 3University of Gothenburg, Ladaporn Bodhidatta1, Sanjaya K. Shrestha2, Jyoti R. Dhakhwa3, Bhola Ram Gothenburg, Sweden Shrestha4, Apichai Srijan1, Carl J. Mason1 1Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, 9:15 a.m. Bangkok, Thailand, 2Walter Reed/AFRIMS Research Unit - Nepal (WARUN), Kathmandu, Nepal, 3Kanti Childrens’ Hospital, Kathmandu, Nepal, 4Bharatpur 716 Hospital, Bharatpur, Nepal A VARIANT IN LONG PALATE, LUNG AND NASAL 8:15 a.m. EPITHELIUM CLONE 1 IS ASSOCIATED WITH CHOLERA IN A BANGLADESHI POPULATION 712 Regina C. LaRocque1, Pardis Sabeti2, Priya Duggal3, Fahima Chowdhury4, Ashraful I. Khan4, Lauren M. Lebrun1, Jason B. Harris1, Edward T. Ryan1, BURDEN OF ENTEROTOXIGENIC ESCHERICHIA COLI Firdausi Qadri4, Stephen B. Calderwood1 (ETEC) DIARRHEA AMONG CHILDREN LESS THAN TWO 1Massachusetts General Hospital, Boston, MA, United States, 2Broad Institute, YEARS IN A RURAL EGYPTIAN COMMUNITY Cambridge, MA, United States, 3Johns Hopkins Bloomberg School of Public Health, 4 Adel M. Mansour1, A. Hafez2, Hind I. Shaheen1, S. El Alkamy2, Khaled Baltimore, MD, United States, International Centre for Diarrhoeal Disease Research, Hassan1, Mark Riddle3, John Sanders4, Adam Armstrong3, A. Kandeel2, Nasr Dhaka, Bangladesh 2

El Sayed Saturday, November 21 1United States Naval Medical Research Unit#3, Cairo, Egypt, 2Ministry of Health, Cairo, Egypt, 3United States Naval Medical Research Center, Bethesda, MD, United States, 4United States Naval Medical Research Center Detachment, Lima, Peru

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9:30 a.m. 9:20 a.m. THE HAJJ: HEALTH LESSONS FOR MASS GATHERINGS 717 Qanta Ahmed Winthrop University Hospital, Mineola, NY, United States FORECASTING CHOLERA EPIDEMICS IN AFRICA Jean-Paul Chretien1, Anna L. Buczak2, Assaf Anyamba3, Jennifer Small3, Trudy L. Philip2, Christine Jessup4, John Nuckols4, Stefan Leyk4, Mark Symposium 118 Miller4, Sheri H. Lewis2 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2Johns Scaling-Up Indoor Residual Spraying for Malaria Control Hopkins University/Applied Physics Laboratory, Laurel, MD, United States, 3NASA- in Africa through the President’s Malaria Initiative Goddard Space Flight Center, Greenbelt, MD, United States, 4Fogarty International Center, National Institutes of Health, Bethesda, MD, United States Washington 5 Saturday, November 21, 8 a.m. - 9:45 a.m. Symposium 117 Indoor Residual Spraying (IRS) is rapidly expanding through support from Global Health and Mass Travel Events the President’s Malaria Initiative (PMI). By the end of 2008, nearly 20 million persons across 14 countries are being protected by PMI-supported Washington 4 IRS programs. While the epidemiological impact can be swift and dramatic, large-scale IRS implementation is an exacting activity, often requiring new Saturday, November 21, 8 a.m. - 9:45 a.m. systems and strategies for Ministries of Health to implement safely and In a globalized and exceedingly mobile world, the potential for spread of effectively. Presentations in this symposium will include the experience, infectious diseases associated with large mass gatherings that can attract lessons and results from the recent rapid scale-up; improving capacity for the millions of travelers is increasingly being recognized as a critical public health safe and judicious use of pesticides; impact of IRS in combination with treated challenge. Mass travel events not only bring together a diversity of cultures mosquito nets; and fi nally, the role of IRS in the context of Integrated Vector from around the world, but also a variety of medical and immunization Management, both in the immediate and long-term control strategy. histories and health risk behaviors. While all travelers are at some risk for infectious and noninfectious hazards, mass travel events present some of the CHAIR world’s most important public health and infection control problems. Extended Michael B. Macdonald stays at gathering sites and crowded accommodations with other travelers, United States Agency for International Development, Washington, DC, United States many of whom may be from developing nations, provide an environment Robert A. Wirtz where emerging infectious diseases can quickly turn into epidemics, leading to Centers for Disease Control and Prevention, Atlanta, GA, United States the risk of potential importation or international spread of infectious disease. Effective disease and behavioral surveillance, as well as timely data analysis, 8 a.m. are necessary to better understand health risks and strengthen evidence base for health policy and prevention related to mass travel events. This symposium SCALING UP INDOOR RESIDUAL SPRAYING IN AFRICA will describe some of the many challenges of detecting developing outbreaks John Chimumbwa and carrying out effective responses at mass travel events. RTI International, Nairobi, Kenya

CHAIR 8:25 a.m. Victor Balaban IMPROVING PESTICIDE MANAGEMENT PRACTICES: Centers for Disease Control and Prevention, Atlanta, GA, United States ENVIRONMENTAL AND WORKER SAFETY IN RELATION 8 a.m. TO IRS IN AFRICA Elissa Beerbohm INTERNATIONAL MASS GATHERINGS FOR SPORTS United States Agency for International Development, Washington, DC, United States EVENTS: LESSONS FROM THE 2008 BEIJING OLYMPICS Emily Jentes 8:55 a.m. Centers for Disease Control and Prevention, Atlanta, GA, United States IMPACT OF IRS IN A COMMUNITY WITH PRE-EXISTING 8:25 a.m. HIGH TREATED MOSQUITO NET USAGE IN MALAWI Themba Mzilahowa PUBLIC HEALTH PREPARATION FOR MASS Liverpool School of Tropical Medicine, Blantyre, Malawi MIGRATIONS: CURRENT EFFORTS IN TRACKING DISEASES AND CONTAINING OUTBREAKS AT MASS 9:25 a.m. TRAVEL EVENTS IRS IN AN INTEGRATED VECTOR MANAGEMENT Aaron T. Fleischauer STRATEGY: RATIONALIZATION AND OPTIMIZATION North Carolina Department of Health and Human Services, Raleigh, NC, United States FOR SUSTAINED CONTROL 8:55 a.m. Jacob Williams RTI International, Washington, DC, United States THE HAJJ: HEALTH PUBLIC HEALTH LESSONS FOR MASS GATHERINGS Ziad A. Memish King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

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Symposium 119 Poster Session C Viewing Exhibit Hall B South Transitioning to Senior Investigator: Experiences from Saturday, November 21, 10:15 a.m. - Noon Developing Countries Wilson A Scientifi c Session 120 Saturday, November 21, 8 a.m. - 9:45 a.m. Mosquitoes - Biochemistry, Molecular Biology and Junior scientists worldwide face many challenges to initiate international research careers, and these obstacles often are harder to overcome in resource- Molecular Genetics II limited settings. Lack of funding opportunities, infrastructure and institutional Salon 1 support, in addition to inadequate legal frameworks, are only some of the many factors young researchers have to deal with in developing countries. The Saturday, November 21, 10:15 a.m. - Noon experiences of senior, more experienced colleagues are critical to understand CHAIR successful and potentially replicable pathways and strategies. Four successful investigators from developing country institutions, all currently directing William Black Research Training Grants from the Fogarty International Center, will share Colorado State University, Fort Collins, CO, United States their experiences and views about the transition to the senior researcher role. Gregory C. Lanzaro University of California, Davis, CA, United States CHAIR Andres G. Lescano 10:15 a.m. Naval Medical Research Center Detachment, Lima, Peru 718 Barbara Sina Fogarty International Center, National Institutes of Health, Bethesda, MD, United States PLEISTOCENE GEOGRAPHIC SEPARATION IN EASTERN PANAMÁ AND NORTHERN COLOMBIA 8 a.m. LEADS TO POPULATION STRUCTURE IN ANOPHELES CLIMBING UP THE RESEARCH LADDER IN AFRICA (NYSSORHYNCHUS) ALBIMANUS (DIPTERA: CULICIDAE) Halima A. Mwenesi Jose Loaiza1, Lina Gutierrez2, Margarita Correa2, Eldredge Bermingham3, Academy for Educational Development, Washington, DC, United States Marilyn Scott1, Richard Wilkerson4, Lotty Birnberg5, Mario Grijalva6, Jose Rovira7, Sara Bickersmith8, Jan E. Conn8 8:25 a.m. 1Macdonald Campus, McGill University, Montreal, QC, Canada, 2Escuela de Microbiologia, Universidad de Antioquia, Medellin, Colombia, 3Smithsonian Tropical BECOMING A SENIOR INVESTIGATOR IN BRAZIL Research Institute, Balboa Ancon, Panama, 4Walter Reed Army Institute for Research, Edgar M. Carvalho Smithsonian Institution, Washington, DC, United States, 5Center for Infectious Disease Federal University of Bahia, Salvador, Brazil Research, Pontifi cal Catholic University of Ecuador, Quito, Ecuador, 6Tropical Disease Institute, Ohio University, Athens, OH, United States, 7Instituto Conmemorativo Gorgas 8:55 a.m. de Estudios de la Salud, Panama City, Panama, 8The Wadsworth Center, New York State Department of Health, Albany, NY, United States PATHWAYS TO SENIOR RESEARCHER: AN EXPERIENCE FROM PAKISTAN 10:30 a.m. Anita K. Zaidi Aga Khan University, Karachi, Pakistan 719

9:25 a.m. GENETIC STRUCTURE OF AEDES ALBOPICTUS IN TRANSITIONING TO SENIOR INVESTIGATOR IN PERU: CAMEROON (CENTRAL AFRICA) SOME THOUGHTS Kamgang Basile1, Brengues Cecile2, Hervé Jean Pierre2, Simard Frédéric3, 1 Hector H. Garcia Christophe Paupy 1 2 3 Universidad Peruana Cayetano Heredia, Lima, Peru IRD/OCEAC, Yaoundé, Cameroon, IRD, Montpellier, France, IRD, Bobo Dioulasso, Burkina Faso

Exhibit Hall Open 10:45 a.m. Exhibit Hall A 720 Saturday, November 21, 9:30 a.m. - 10:30 a.m. EPIDEMIOLOGICAL IMPORTANCE AND POPULATION Saturday, November 21 Coffee Break GENETICS OF THE HUMAN MALARIA MOSQUITO Exhibit Hall A ANOPHELES NILI SL IN AFRICA Saturday, November 21, 9:45 a.m. - 10:15 a.m. Cyrille Ndo1, Christophe Antonio-Nkondjio1, Anna Cohuet2, Pierre Kengne2, Diego Ayala2, Pierre Ngassam3, Isabelle Morlais2, Didier Fontenille2, Frédéric Supported with funding from SCYNEXIS, Inc. Simard2 1Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale, Poster Session C Set-Up Yaoundé, Cameroon, 2Institut de Recherche pour le Développement, Unité de Recherche 3 Exhibit Hall B South 016, Montpellier, France, University of Yaoundé I, Yaoundé, Cameroon Saturday, November 21, 9:45 a.m. - 10:15 a.m.

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11 a.m. 10:15 a.m.

721 725

SPECIES DELIMITATION IN SOUTH EAST ASIAN HEPATITIS E OUTBREAK IN A LOW INCOME URBAN VECTORS OF MALARIA COMMUNITY IN BANGLADESH Magdalena Zarowiecki M. Jahangir Hossain1, Hossain M S Sazzad1, Shahana Parveen1, Saiful Natural History Museum, London, United Kingdom Islam1, Labib Imran Faruque1, Shaila Arman1, Dawlat Khan1, M. Mushtuq (ACMCIP Abstract) Husain1, Yasmin Jahan1, Mahmudur Rahman1, Stephen P. Luby2, Emily S. Gurley1 11:15 a.m. 1International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, 2Centers for Disease Control and Prevention, Atlanta, GA, United States 722 10:30 a.m. NEOTROPICAL ANOPHELES TRIANNULATUS COMPLEX: 726 PHYLOGEOGRAPHY AND DEMOGRAPHIC HISTORY BASED ON MITOCHONDRIAL AND NUCLEAR MARKERS FILOVIRUS SEROURVEY FOLLOWING AN OUTBREAK 1 1 1 Marta Moreno Leirana , Wesley Harlow , Jessica Hildebrandt , Teresa OF MARBURG HEMORRHAGIC FEVER --- IBANDA AND Fernandes Silva-do-Nascimento2, Ricardo Lourenço-de-Oliveira2, Maria Anice Mureb Sallum3, Gary N Fritz4, Freddy Ruiz5, Richard Wilkerson5, KAMWENGE DISTRICTS, UGANDA, 2007 Jose R Loaiza6, Maria Julia Dantur7, Marinete AM Póvoa8, Lina Andrea Eileen C. Farnon1, Jennifer A. Adjemian1, Edgar Kansiime2, Johanna E. Gutiérrez-Builes9, Margarita O. Correa9, Jan E Conn1 Rahman1, Godfrey S. Bwire2, Samuel Kahirita3, Atek Kagirita2, Joseph F. 1Wadsworth Center, New York Department of Health, Albany, NY, United States, Wamala2, Pierre E. Rollin1 2Departamento de Entomología, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil, 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Field 3Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Epidemiology and Laboratory Training Program, Ministry of Health, Kampala, Paulo, São Paulo, Brazil, 4Department of Biological Sciences, Eastern Illinois University, Uganda, 3Kamwenge District Health Offi ce, Ministry of Health, Kamwenge, Uganda Charleston, IL, United States, 5Division of Entomology, Walter Reed Army Institute of Research, Silver Spring, MD, United States, 6Smithsonian Tropical Research Institute, 10:45 a.m. Balboa, Panama, 7Instituto Superior de Entomología “Dr. Abraham Willink”, Facultad de Ciencias, Naturales e Instituto Miguel Lillo, Universidad Nacional de Tucumán, 727 Tucuman, Argentina, 8Instituto Evandro Chagas, Secção de Parasitologia, Belém, Brazil, 9Grupo de Microbiología Molecular, Escuela de Microbiología, Universidad de Antioquia, EPIDEMIOLOGY OF LASSA FEVER IN THE MANO RIVER Medellín, Colombia UNION COUNTRIES OF WEST AFRICA, 2004-2008 11:30 a.m. James J. Bangura1, Joseph Fair2, Augustine Goba2, Sheik H. Khan1, Richard Fonnie1, Robert F. Garry2, Lina M. Moses2, Francis Nylander3, Jerry Daboi4, 723 Louise Kpoto5, Peter C. Lugala6, Lamine Koivogui7, Mamadi Coulibaly8, Margaret Lamunu9, Cathy Roth9, Daniel G. Bausch2 1 LOW LINKAGE DISEQUILIBRIUM IN ANOPHELES Ministry of Health and Sanitation, Lassa Fever Program, Kenema Government Hospital, Sierra Leone, 2Tulane University Health Sciences Center, New Orleans, LA, GAMBIAE S.L. POPULATIONS United States, 3World Health Organization, Freetown, Sierra Leone, 4Ministry of Anna Cohuet Health, Monrovia, Liberia, 5Ministry of Health and Social Welfare, Monrovia, Liberia, Institut de Recherche pour le Développement, Bobo Dioulasso, Burkina Faso 6World Health Organization, Monrovia, Liberia, 7Ministry of Health, Conakry, Guinea, 8Ministry of Higher Education and Scientifi c Research, N’Zerekore, Guinea, 9World 11:45 a.m. Health Organization, Geneva, Switzerland

724 11 a.m.

POPULATION GENETICS OF LUTZOMYIA LONGIFLOCOSA 728 (DIPTERA: PSYCHODIDAE) POPULATIONS FROM COLOMBIA USING THE CYTOCHROME OXIDASE 1 SEROPREVALENCE OF IGG ANTIBODIES AGAINST GENE PHLEBOVIRUSES IN HUMANS IN NORTHERN AFGHANISTAN Sahar Usmani-Brown, Leonard E. Munstermann Yale University, New Haven, CT, United States Gerhard Dobler1, Michael Faulde2, Sabine Schaper1, Sandra Essbauer1 1Bundeswehr Institute of Microbiology, Munich, Germany, 2Central Institute of the Scientifi c Session 121 German Armed Forces, Koblenz, Germany 11:15 a.m. Viruses II 729 Salon 2 Saturday, November 21, 10:15 a.m. - Noon A PROFILE OF INFLUENZA VIRUS INFECTION IN ACUTE RESPIRATORY ILLNESS IN GHANA CHAIR William K. Ampofo1, Karl C. Kronmann2 James J. Bangura 1Noguchi Memorial Institute for Medical Research, Accra, Ghana, 2NAMRU-3 Ghana Ministry of Health and Sanitation, Kenema, Sierra Leone Detachment, Noguchi Memorial Institute for Medical Research, Accra, Ghana Eileen C. Farnon Centers for Disease Control and Prevention, Fort Collins, CO, United States

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11:30 a.m. 11:05 a.m. RECENT MALARIA CONTROL PROGRAM 730 ACHIEVEMENTS IN SUB-SAHARAN AFRICA: COVERAGE AND INTERVENTION EFFECTIVENESS INFLUENZA SENTINEL SURVEILLANCE - RWANDA, JULY 2008-MARCH 2009 Richard W. Steketee Malaria Control Evaluation Partnership in Africa, PATH, Ferney-Voltaire, France Jackson Sebeza1, Alice Kabanda2, Joseph Rukelibuga3, Marie-Aime Muhimpundu1, Rakhee Palekar4, John Rusine2, Odette Mukabayire2, 11:30 a.m. Michael Kramer1 1Trac Plus-MOH, Kigali, Rwanda, 2National Reference Laboratory, Kigali, Rwanda, COMPARING IMPACT OF MALARIA CONTROL IN 3Centers for Disease Control and Prevention, Kigali, Rwanda, 4Centers for Disease SELECTED HIGH-BURDEN AFRICAN COUNTRIES USING Control and Prevention, Baltimore, MD, United States ROUTINE AND OTHER SOURCES OF DATA 11:45 a.m. Robert D. Newman World Health Organization Global Malaria Program, Geneva, Switzerland 731 Symposium 123 SPATIAL ANALYSIS OF HEMORRHAGIC FEVER WITH RENAL SYNDROME IN SHANDONG PROVINCE, The Role of Vaccines in Integrated Control of Helminth EASTERN CHINA, 1968-2005 Infections Li-Qun Fang1, Song Liang2, Xian-Jun Wang3, Sake J. de Vlas4, Zhi-Qiang Wang3, Shao-Xia Song3, Wen-Yi Zhang1, You-Fu Xu1, Hong Yang1, Wu- Delaware A Chun Cao1 Saturday, November 21, 10:15 a.m. - Noon 1Beijing Institute of Microbiology and Epidemiology, Beijing, China, 2The Ohio State University, Columbus, OH, United States, 3Shandong Center for Disease Control and Recombinant vaccines against human helminths are in pre-clinical studies and Prevention, Jinan, China, 4Department of Public Health, University of Medical Center in some cases already in clinical trials. These include:1) three different Necator Rotterdam, Rotterdam, The Netherlands americanus hookworm vaccine antigens using alum as the adjuvant; 2) vaccines against schistosomiasis caused by Schistosoma mansoni or S. haematobium. Symposium 122 Transmission blocking veterinary vaccines for zoonotic S. japonicum are also showing promise; and 3) a vaccine against the infective larvae of Onchocerca volvulus. This symposium will discuss highlights and early product development Reports of High Impact in Malaria Control Programs: and experiences with these helminth vaccines. Too Good to Be True? CHAIR Supported with funding from the Bill & Melinda Gates Peter J. Hotez Foundation The George Washington University, Washington, DC, United States Salon 3 Don McManus Saturday, November 21, 10:15 a.m. - Noon Queensland Institute of Medical Research, Queensland, Australia

This symposium will discuss the recent reports of impact that have been 10:15 a.m. extremely encouraging - almost too good to be true. The session will address THE DEVELOPMENT OF A RECOMBINANT VACCINE the issue of malaria control program effectiveness, and discuss the elements of the impact assessment. This symposium hopes to stimulate a discussion about AGAINST HUMAN ONCHOCERCIASIS general and specifi c aspects of malaria control interventions, including LLINS/ Sara Lustigman IRS, whose effectiveness is often greater than their reported effi cacy. New York Blood Center, New York, NY, United States

CHAIR 10:40 a.m. Kathryn S. Aultman DEVELOPMENT OF A HUMAN SCHISTOSOMA MANSONI Bill & Melinda Gates Foundation, Seattle, WA, United States VACCINE 10:15 a.m. Alex Loukas Queensland Institute of Medical Research, Brisbane, Queensland, Australia MAPS OF MALARIA TRANSMISSION AS AN ALTERNATIVE APPROACH TO ESTABLISHING 11:05 a.m. BASELINES AND AUDITING CHANGE PROSPECTS FOR SCHISTOSOMA JAPONICUM VACCINES

Simon Hay Donald P. McManus Saturday, November 21 University of Oxford, Oxford, United Kingdom The Queensland Institute of Medical Research, Brisbane, Queensland, Australia 10:40 a.m. 11:30 a.m. CONTROL OF MALARIA VECTORS: DOES HOOKWORM VACCINE DEVELOPMENT EFFECTIVENESS EXCEED EFFICACY? Jeff Bethony Marc Coosemans The George Washington University, Washington, DC, United States Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium

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Symposium 124 10:15 a.m. 732 Diagnostics at the End-Game: Assessing Disease Elimination MANAGEMENT OF PNEUMONIA AND MALARIA AT THE Delaware B COMMUNITY LEVEL IN ZAMBIA 1 2 1 Saturday, November 21, 10:15 a.m. - Noon Kojo Yeboah-Antwi , Portipher Pilingana , William B. MacLeod , Katherine Semrau1, Kazungu Siazeele2, Penelope Kalesha3, Busiku Hamainza4, A number of parasitic diseases such as onchocerciasis, lymphatic fi lariasis and Euphrasia Mtonga3, Pascalina Chanda5, Lora Sabin1, Karen Kamholz6, Erin schistosomiasis now can look to elimination as a goal in light of the massive Twohig1, Donald M. Thea1, Davidson H. Hamer1 1 collaborative effort between government bodies, for-profi t entities, NGOs Center for International Health and Development, Boston, MA, United States, 2 3 and academia. However, while this paradigm has led to tremendous progress Chikankata Mission Hospital, Chikankata, Zambia, Child Health Unit, Ministry 4 in the context of disease control, diagnostic tools with the requisite specifi city of Health, Lusaka, Zambia, National Malaria Control Center, Ministry of Health, 5 6 and sensitivity needed to assess elimination status simply do not exist. This Lusaka, Zambia, Ministry of Health, Lusaka, Zambia, Boston University School of Medicine, Department of Pediatrics, Boston, MA, United States symposium will discuss the theory, design and implementation of diagnostic tools that can operate in low prevalence scenarios, such as those found in areas 10:30 a.m. nearing elimination. Topics to be presented include critical aspects of disease diagnostics, such as statistical treatment of data to maximize sensitivity and/ or specifi city, powerful emerging technologies for the profi ling of biological 733 samples and progress achieved by current global programs towards parasite elimination using existing diagnostics. ANTIGENIC AND PHYLOGENETIC ANALYSIS OF INFLUENZA VIRUSES IN KENYA FROM 2006-08 WITHIN CHAIR THE CONTEXT OF REGIONAL AND GLOBAL INFLUENZA Tobin J. Dickerson DRIFT The Scripps Research Institute, La Jolla, CA, United States David Schnabel1, Wallace Bulimo2, Rachel Achilla2, Tom Gibbons3, Scott Frank Richards Gordon1 The Carter Center, Atlanta, GA, United States 1United States Army Medical Research Unit - Kenya, Nairobi, Kenya, 2Kenya Medical Research Institute, Nairobi, Kenya, 3United States Air Force School of Aerospace 10:15 a.m. Medicine, Brooks City-Base, TX, United States BILL AND MELINDA GATES FOUNDATION: TARGETING 10:45 a.m. FILARIASIS ELIMINATION Julie Jacobson 734 Bill and Melinda Gates Foundation, Seattle, WA, United States VALIDATION OF THE MICROSCOPIC-OBSERVATION 10:40 a.m. DRUG-SUSCEPTIBILITY (MODS) TECHNIQUE MAXIMIZING SENSITIVITY AND SPECIFICITY IN FIELD FOR DRUG-SUSCEPTIBILITY TESTING DURING DIAGNOSTICS TUBERCULOSIS THERAPY Thomas Unnasch Marco Tovar1, Teresa Valencia1, Robert Gilman2, Lucy Caviedes1, Eric University of South Florida, Tampa, FL, United States Ramos3, Jessica Alvarado3, Willi Quino1, Beatriz Herrera1, Carlton Evans1 1Universidad Peruana Cayetano Heredia, Lima, Peru, 2Johns Hopkins Bloomberg School 11:05 a.m. of Public Health, Baltimore, MD, United States, 3Asociacion Benefi ca Prisma, Lima, VALIDATING THE ELIMINATION OF INFECTION - Peru DIAGNOSTIC CHALLENGES AT THE END GAME 11 a.m. Patrick Lammie Centers for Disease Control and Prevention, Atlanta, GA, United States 735

11:30 a.m. GAPS IN THE GLOBAL USE OF HAEMOPHILUS METABOLOMICS AS A SENSITIVE ONCHOCERCIASIS INFLUENZAE TYPE B CONJUGATE VACCINE DIAGNOSTIC Adam L. Cohen1, Linda R. Ojo1, Rosalyn E. O’Loughlin2, Karen M. Judith Denery Edmond2, Sharmila S. Shetty3, Allyson P. Bear3, Jennifer D. Loo1, Lois The Scripps Research Institute, La Jolla, CA, United States Privor-Dumm3, Ulla K. Griffi ths2, Patrick L. Zuber4, Gillian F. Mayers4, Rana Hajjeh1 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Department of Scientifi c Session 125 Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom, 3Department of International Health, Johns Hopkins Pneumonia, Respiratory Infections and Tuberculosis Bloomberg School of Public Health, Baltimore, MD, United States, 4Department of Immunizations, Vaccines and Biologicals, Family and Child Health, World Health Virginia AB Organization, Geneva, Switzerland Saturday, November 21, 10:15 a.m. - Noon

CHAIR Robert Breiman Centers for Disease Control and Prevention - Kenya, Nairobi, Kenya W. Abdullah Brooks International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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11:15 a.m. Studies and Sandwich Certifi cate Training Program: Different programs with different goals but both are designed to assist developing nations in 736 capacity building in science and technology; and 4) International Health in the Philippines: A program focusing on rural and urban global health issues TREATING ISONIAZID MONORESISTANT TB WITH including the epidemiology of infectious, non-infectious and acute or chronic diseases prevalent in the Philippines. STANDARD FIRST-LINE REGIMENS RESULTS IN HIGH RATES OF TREATMENT FAILURE, TB RECURRENCE AND CHAIR TB-RELATED DEATH Madhavi Dandu Jonathan M. Sherman1, Marco Tovar2, Robert H. Gilman3, Luz Caviedes2, University of California, San Francisco, San Francisco, CA, United States Giselle Soto4, Antonio Bernabe2, Mirko Zimic2, Lilia Cabrera4, Jaime Ortiz5, Michael Kron Nilda Victoria Trejo Maguina6, Richard Rodriguez5, Carlton A. Evans7 Medical College of Wisconsin, Milwaukee, WI, United States 1Mayo Medical School, Rochester, MN, United States, 2Faculty of Sciences, Universidad 3 Peruana Cayetano Heredia, Perú, Lima, Peru, Johns Hopkins University Bloomberg 10:15 a.m. School of Public Health, Baltimore, MD, United States, 4Asociacion Benefi ca PRISMA, Lima, Peru, 5Hospital Maria Auxiliadora, Lima, Peru, 6National Tuberculosis Control GLOBAL HEALTH CLINICAL SCHOLARS PROGRAM 7 Program, Lima, Peru, IFHAD: Innovation For Health And Development, London, Chris Stewart United Kingdom University of California San Francisco, San Francisco, CA, United States 11:30 a.m. 10:40 a.m. 737 MASTERS IN GLOBAL HEALTH John Ziegler INVESTIGATIONS OF CLOSE CONTACTS OF PATIENTS University of California San Francisco, San Francisco, CA, United States WITH LABORATORY-CONFIRMED H5N1 INFECTION IN 11:05 a.m. INDONESIA, IN 2007 Vivi Setiawaty, Siti Isfandari, Ni Ketut Susilarini, Krisnanur A. Pangesti, INTERNATIONAL TRAINEESHIPS IN AIDS PREVENTION Endang R. Sedyaningsih STUDIES National Institute of Health Research and Development, Jakarta, Indonesia Jeffrey Mandel University of California San Francisco, San Francisco, CA, United States 11:45 a.m. 11:30 a.m. 738 DEVELOPING A NEW GLOBAL HEALTH PATHWAY EDUCATIONAL SYSTEM IN MILWAUKEE BLOOD CULTURES FOR THE DIAGNOSIS OF DRUG- RESISTANT TUBERCULOSIS IN RURAL SOUTH AFRICA Richard Olds Medical College of Wisconsin, Milwaukee, WI, United States Scott K. Heysell1, Tania A. Thomas1, Francois J. Eksteen2, Anthony P. Moll2, Neel R. Gandhi3, Palav Babaria1, Umesh G. Lalloo4, Gerald Friedland1, N. Sarita Shah3 Symposium 127 1Yale University, New Haven, CT, United States, 2Church of Scotland Hospital, Tugela Ferry, South Africa, 3Albert Einstein College of Medicine, New York City, NY, United Malaria: Impact of Natural Selection on Transmission and 4 States, University of KwaZulu-Natal, Durban, South Africa Disease Symposium 126 Washington 1 Saturday, November 21, 10:15 a.m. - Noon Crossing Boundaries: Models of North-South and Interprofessional Education This symposium will discuss the concept of natural selection in malaria—how has the parasite selected variants in the human genome; how does the Virginia C host immune system or drug pressure select parasite variants; and how do insecticides select for mosquito variants? In addition, this symposium will Saturday, November 21, 10:15 a.m. - Noon explore strategies to identify genes under natural selection and the implications for understanding malaria biology and development of diagnostic tools and Global health educators are charged with training health professionals and intervention strategies. others to become leaders to improve health and eliminate disease. The goal is to guide scientists, clinicians, activists and others to create knowledge, apply CHAIR best practices and recent discoveries and to understand the determinants of

health. These complex challenges require a multidisciplinary and multinational Dyann F. Wirth Saturday, November 21 response. All global health education programs should seek to break silos, Harvard School of Public Health, Boston, MA, United States use interdisciplinary teams, create global partnerships, emphasize roles Marc A. Muskavitch of communities, universities, governments and NGOs in improving the Boston College, Boston, MA, United States health of populations. This symposium will showcase several educational programs at UCSF and The Medical College of Wisconsin which highlight 10:15 a.m. interdisciplinary and North-South partnerships: 1) Global Health Clinical NATURAL SELECTION AND TRANSMISSION OF Scholars Program: Graduate level health professional students from different disciplines formally incorporate global health into their clinical and research PLASMODIUM FALCIPARUM MALARIA training; 2) Masters in Global Health: The program prepares graduates for Sarah K. Volkman leadership careers in international health policy, health care, research, or Harvard School of Public Health, Cambridge, MA, United States development by stressing hands-on global health practice through lectures, seminars, and fi eldwork; 3) International Traineeships in AIDS Prevention

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10:40 a.m. 11:10 a.m. PARASITE SELECTION ON THE HUMAN HOST: THE PROMOTING NET USE USING VOLUNTEER HOME HEMOGLOBIN STORY VISITS: RESULTS FROM RED CROSS HANG UP/KEEP UP Rick Fairhurst ACTIVITIES National Institutes of Health, Bethesda, MD, United States Salim Sohani Canadian Red Cross, Ottawa, ON, Canada 11:05 a.m. ANTIGENIC POLYMORPHISM AND VARIATION OF 11:35 a.m. PARASITES UNDER IMMUNE SELECTION THE PROBLEM WITH NET USE IN HUMANITARIAN David Conway CRISES: CASE STUDY EASTERN CHAD Medical Research Council—The Gambia, Fajara, Gambia Richard Allan The Mentor Initiative, Toulouse, France 11:30 a.m. SELECTION ACTING ON THE VECTOR: IMPACTS OF Symposium 129 INSECTICIDES Martin Donnelly Towards the Control of Globally Important Vector-Borne Liverpool School of Tropical Medicine, Liverpool, United Kingdom Diseases: Prevention of Transmission in the Home and Indoor Environment Symposium 128 Washington 3 Net Results: Scaling up LLIN Use for Malaria Control Saturday, November 21, 10:15 a.m. - Noon

Washington 2 In the developing world, the home is not always a safe place; annually it is Saturday, November 21, 10:15 a.m. - Noon the site of hundreds of millions of infections and more than one million deaths caused by vector-borne pathogens. For many globally important vector-borne With massive scale up of LLIN distribution in recent years, more African diseases, including malaria in sub-Saharan Africa, dengue, Chagas disease, households own nets. However, fi eld programs are now faced with the lymphatic fi lariasis and leishmaniasis, the most signifi cant epidemiological challenge of closing the gap between ownership of nets and their use, which point of contact between vectors and humans is the home or other indoor is critical for achieving impact. This symposium focuses on making the link environments. Thus, in the developing world the home is often not a safe between distribution and impact by increasing the use of Long Lasting place; rather, it can be a dangerous place. This symposium will describe how Insecticidal Nets (LLINs). Speakers will discuss recent evidence in behavior targeting vectors in homes has helped to combat four globally important VBDs change communication to achieve high rates of use for LLINs, including (malaria, dengue, Chagas disease and lymphatic fi lariasis). Special emphasis results from behavioral determinant tracking methods in Madagascar, patterns will be placed on non-stovepiped interventions to broadly prevent endophilic of net use within households over the course of a rainy season in Tanzania; transmission of vector-borne pathogens in the home to reduce the public household visits by community volunteers and issues for promoting net use in health burdens of globally important VBDs in the developing world. humanitarian crises. CHAIR CHAIR Barry J. Beaty Matthew Lynch Colorado State University, Fort Collins, CO, United States Johns Hopkins University Center for Communication Programs, Baltimore, MD, United Jo Lines States London School of Hygiene and Tropical Medicine, London, United Kingdom CHAIR 10:15 a.m. Chris White Population Services International, Washington, DC, United States INTRODUCTION - THE CRITICAL IMPORTANCE OF THE HOME IN VECTOR-BORNE DISEASE TRANSMISSION 10:15 a.m. AND CONTROL TRACKING THE DETERMINANTS OF NET USE TO Barry Beaty INFORM PROGRAMS IN MADAGASCAR Colorado State University, Fort Collins, CO, United States Iarimalanto Rabary 10:35 a.m. Population Services International, Antananarivo, Madagascar MALARIA - MALARIA CONTROL - THE EFFICACY 10:45 a.m. OF TARGETING THE VECTOR IN THE HOME PATTERNS OF NET USE DURING RAINY SEASON IN ENVIRONMENT KONGWA, TANZANIA: WEEKLY HOUSEHOLD VISITS Jo Lines Hannah Koenker London School of Hygiene and Tropical Medicine, London, United Kingdom Johns Hopkins University Center for Communication Programs, Baltimore, MD, United States 10:55 a.m. DENGUE - INNOVATIVE APPROACHES TO CONTROL AE. AEGYPTI IN THE HOME ENVIRONMENT Lars Eisen Colorado State University, Fort Collins, CO, United States

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11:15 a.m. Scientifi c Session 131 CHAGAS DISEASE: THE POTENTIAL AND LIMITATIONS OF CONTROLLING T. INFESTANS IN THE HOME Malaria - Regulation of Cellular Immunity in Malaria Uriel Kitron Emory University, Atlanta, GA, United States Washington 5 Saturday, November 21, 10:15 a.m. - Noon 11:40 a.m. CHAIR VECTOR CONTROL: THE FORGOTTEN COMPONENT Kirsten E. Lyke FOR EFFECTIVE CONTROL OF FILARIASIS University of Maryland, Baltimore, MD, United States Graham White Martha Sedegah USDA-ARS, Center for Medical, Agricultural and Veterinary Entomology, Gainesville, Naval Medical Research Center, Silver Spring, MD, United States FL, United States 10:15 a.m. Symposium 130 739 Communicable Diseases in Post-Confl ict Settings IL-15 MAINTAINS A RESERVOIR OF CENTRAL MEMORY Washington 4 CD8 T CELLS THAT ARE REQUIRED FOR PROTRACTED Saturday, November 21, 10:15 a.m. - Noon PROTECTION AGAINST PLASMODIUM BERGHEI INFECTION Persons surviving confl icts are especially vulnerable to communicable diseases because of mass migration leading to overcrowding, environmental Urszula Krzych, Nick Steers, Joanne Lumsden, Dmitri Berenzon, Dmitry degradation, poor housing, water, sanitation and food, or lack of preventive Liepinsh, Robert J. Schwenk and curative healthcare. The populations of greatest concern are internally Walter Reed Army Institute of Research, Silver Spring, MD, United States displaced persons or refugees and people living under fragile governments. (ACMCIP Abstract) This session will present three public health areas involved in assessing 10:30 a.m. the health status of these populations: surveillance conducted in healthcare facilities, environmental responses to communicable disease outbreaks and specifi c healthcare program evaluations. This session presents some of the 740 current communicable diseases affecting these vulnerable persons, including traditional, emerging and re-emerging diseases. LIVER CCD8α+DC FROM MICE IMMUNIZED WITH RADIATION-ATTENUATED PLASMODIUM BERGHEI CHAIR SPOROZOITES MEDIATE THE INDUCTION OF LIVER Susan Temporado Cookson EFFECTOR CD8+ T CELLS AGAINST PRE-ERYTHROCYTIC Centers for Disease Control and Prevention, Atlanta, GA, United States STAGE INFECTION 10:15 a.m. Ousman Jobe, Robert J. Schwenk, Urszula Krzych Walter Reed Army Institute of Research, Silver Spring, MD, United States UNHCR HEALTH INFORMATION SYSTEM (HIS) (ACMCIP Abstract) FINDINGS AMONG REFUGEE CHILDREN UNDER FIVE YEARS OF AGE 10:45 a.m. Basia Tomczyk 741 Centers for Disease Control and Prevention, Atlanta, GA, United States 10:45 a.m. EXPRESSION OF FOXP3, IL-10 AND TGF-β1 IN IP-10 DEFICIENT C57BL/6 MICE WITH EXPERIMENTAL MALARIA BURDEN AMONG REFUGEES, HIS FINDINGS CEREBRAL MALARIA FOR CHILDREN UNDER FIVE YEARS OF AGE Bismark Y. Sarfo1, Nana Wilson1, Danielle Whittaker2, Vincent Bond1, Byron Holly A. Williams Ford1, Jonathan Stiles1 Centers for Disease Control and Prevention, Atlanta, GA, United States 1Morehouse School of Medicine, Atlanta, GA, United States, 2Vanderbilt University, Nashville, TN, United States 11:10 a.m. (ACMCIP Abstract) ENVIRONMENTAL RESPONSES TO CHOLERA AND HEPATITIS E OUTBREAKS AMONG VULNERABLE 11 a.m. Saturday, November 21 AFRICAN POPULATIONS, 2008 742 Thomas Handzel Centers for Disease Control and Prevention, Atlanta, GA, United States INTERFERON-ALPHA PROMOTER HAPLOTYPES AND 11:35 a.m. SUSCEPTIBILITY TO SEVERE MALARIAL ANEMIA Prakasha Kempaiah1, Collins Ouma2, Gregory C. Davenport3, Samuel B. HEALTHCARE PROGRAM EVALUATION TOOLKITS— Anyona2, Tom Were2, John M. Ong’echa2, James B. Hittner4, Douglas J. DEVELOPMENT AND INITIAL FINDINGS Perkins1 Susan Temporado Cookson 1University of New Mexico, Albuquerque, NM, United States, 2University of New Mexico/ Centers for Disease Control and Prevention, Atlanta, GA, United States KEMRI, Kisumu, Kenya, 3University of Pittsburgh, Pittsburgh, PA, United States, 4College of Charleston, Charleston, SC, United States

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11:15 a.m. 10:15 a.m.

743 746

IDENTIFICATION OF HLA RESTRICTED CD8+ T-CELL COMBINATION OF BENZNIDAZOLE AND NIFURTIMOX EPITOPES ON THE PLASMODIUM FALCIPARUM AMA1 PLUS POSACONAZOLE ENHANCES ACTIVITY AGAINST PROTEIN TRYPANOSOMA CRUZI IN EXPERIMENTAL CHAGAS Martha Sedegah1, Yohan Kim2, Shannon McGrath1, Harini Ganeshan1, DISEASE Jennylynn Lejano1, Stephen Abot1, Glena Banania1, Maria Belmonte1, Maria Terezinha Bahia1, A. Talvani1, Shing Chang2, Isabela Ribeiro3 Renato Sayo1, Fouzia Farooq1, Denise L. Doolan3, Bjoern Peters2, Joseph 1Laboratório de Doença de Chagas, Núcleo de Pesquisa em Ciências Biológicas, Bruder4, Christopher R. King4, Lorraine Soisson5, Carter Diggs5, Christian F. Universidade Federal de Ouro Preto (UFOP), Ouro Preto, Brazil, 2Drugs for Neglected Ockenhouse1, Michael Hollingdale1, Alessandro Sette2, Thomas L. Richie1 Diseases initiative (DNDi), Geneva, Switzerland, 3Drugs for Neglected Diseases initiative 1United States Military Malaria Vaccine Program, Silver Spring, MD, United (DNDi) - Latin America, Rio de Janeiro, Brazil States, 2La Jolla Institute for Allergy and Immunology, La Jolla, CA, United States, 3Queensland Institute of Medical Research, Brisbane, Australia, 4GenVec, Gaithersburg, 10:30 a.m. MD, United States, 5United States Agency for International Development, Washington, DC, United States 747 11:30 a.m. CALCULATING DRUG NEEDS AND COSTS FOR 744 TREATING VISCERAL LEISHMANIASIS IN THE INDIAN SUBCONTINENT AND AFRICA USING LOCAL PATIENT EFFECTS OF CONCOMITANT SCHISTOSOMA ANTHROPOMETRIC DATA HAEMATOBIUM INFECTION ON THE T REGULATORY Michael O. Harhay1, François Chappuis2, Suman Rijal3, Shyam Sundar4, CELL RESPONSE ELICITED BY ACUTE PLASMODIUM Piero L. Olliaro5 1 2 FALCIPARUM MALARIA INFECTION IN MALIAN University of Pennsylvania, Philadelphia, PA, United States, Geneva University Hospitals, Travel and Migration Medicine Unit, Geneva, Switzerland, 3B.P. Koirala CHILDREN Institute of Health Sciences, Dharan, Nepal, 4Institute of Medical Sciences, Banaras Kirsten E. Lyke1, Abdoulaye Dabo2, Charles Arama3, Modibo Daou2, Issa Hindu University, Varanasi, India, 5UNICEF/UNDP/World Bank/WHO Special Diarra2, Christopher V. Plowe4, Ogobara K. Doumbo2, Marcelo B. Sztein1 Programme on Research and Training in Tropical Diseases (TDR), World Health 1University of Maryland, Baltimore, MD, United States, 2Malaria Research and Organization, Geneva, Switzerland Training Center, University of Bamako, Bamako, Mali, 3Department of Immunology, University of Stockholm, Stockholm, Mali, 4Howard Hughes Medical Institute, 10:45 a.m. Baltimore, MD, United States 748 11:45 a.m. SCYX-6759, AN ORALLY BIOAVAILABLE OXABOROLE 745 6-CARBOXAMIDE, ACHIEVES THERAPEUTICALLY RELEVANT EXPOSURE IN BRAIN AND CSF LEADING ANTENATAL INFECTION WITH SCHISTOSOMIASIS TO 100% CURES IN A MOUSE MODEL OF CNS-STAGE INCREASES SUSCEPTIBILITY TO MALARIA IN KENYAN HUMAN AFRICAN TRYPANOSOMIASIS CHILDREN 1 2 1 1 1 1 2 3 Stephen Wring , Cyrus Bacchi , Beth Beaudet , Tana Bowling , Daitao Indu Malhotra , Peter Mungai , Alex Wamachi , John H. Ouma , Davy 1 3 4 1 4 2 4 1 Chen , Robert Don , Yvonne Freund , Eric Gaukel , Kurt Jarnagin , Matthew Koech , Eric Muchiri , Christopher L. King 1 1 1 1 1 1 2 Jenks , Luke Mercer , Bakela Nare , Andy Noe , Matthew Orr , Robin Case Western Reserve University, Cleveland, OH, United States, Kenya Medical 1 4 1 1 2 3 4 Parham , Jacob Plattner , Cindy Rewerts , Jessica Sligar , Nigel Yarlett , Research Institute, Nairobi, Kenya, Kenyatta University, Nairobi, Kenya, Division of Robert Jacobs1 Vector Borne Diseases, Nairobi, Kenya 1SCYNEXIS Inc., Research Triangle Park, NC, United States, 2Pace University, New (ACMCIP Abstract) York, NY, United States, 3Drugs for Neglected Diseases initiative, Geneva, Switzerland, 4Anacor Pharmaceuticals Inc., Palo Alto, CA, United States Scientifi c Session 132 11 a.m. Kinetoplastida: Epidemiology, Diagnosis and Treatment 749 Wilson A Saturday, November 21, 10:15 a.m. - Noon IDENTIFICATION OF NEW AMINOQUINOLINE COMPOUNDS ACTIVE AGAINST VISCERAL CHAIR LEISHMANIASIS USING AN EX VIVO MODEL SYSTEM Nisha Garg Alex G. Peniche1, Bruno L. Travi1, Elvia Y. Osorio1, Adam R. Renslo2, Peter University of Texas Medical Branch, Galveston, TX, United States C. Melby1 1South Texas Veterans Health Care System/University of Texas Health Science Center, San Antonio, TX, United States, 2University of California-San Francisco, San Francisco, CA, United States

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11:15 a.m. 754

750 SURVEILLANCE OF RICKETTSIAL PATHOGENS ISOLATED FROM TICKS IN THE REPUBLIC OF GEORGIA ANTILEISHMANIAL ACTIVITY OF SELECTED FDA- Tamasin R. Yarina1, Todd E. Myers1, John S. Lee2, Monica L. O’Guinn3, APPROVED DRUGS IN A MURINE CUTANEOUS Nicolas Tsertsvadze4, Nino Vephkhvadze5, Giorgi Babuadze4, Ketevan LEISHMANIASIS MODEL Sidamonidze4, Maka Kokhreidze5, Marina Donduashvili5, Allen L. Richards1 1 2 David Saunders1, Qiqui Li2, Misty Carlson2, Lisa Xie2, Qiang Zheng2, Jing Naval Medical Research Center, Silver Spring, MD, United States, United States Zhang2, Juan Mendez2, John Tally2, Suping Jiang2, Peter Weina2, Alan Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD, United States, 3 4 Magill2, Max Grogl2 Armed Forces Institute of Pathology, Washington, DC, United States, National Centers 5 1Armed Forces Research Institute of the Medical Sciences, Bangkok, Thailand, 2Walter for Disease Control, Tbilisi, Georgia, Laboratory of the Ministry of Agriculture, Tbilisi, Reed Army Institute of Research, Silver Spring, MD, United States Georgia 11:30 a.m. 755

751 ULTRASTRUCTURAL STUDY OF AEDES ALBOPICTUS SKUSE, 1895 (DIPTERA: CULICIDAE) HEMOCYTES NOVEL COMPOUNDS FOR THE TREATMENT OF Fabio A. Brayner-Santos1, Helena R. Araujo2, Luiz C. Alves1, Paulo F. CHAGAS DISEASE Pimenta3 1 2 Martine Keenan1, Wayne M. Best1, Tanya Armstrong2, Andrew Thompson2, National Institutes of Health, Rockville, MD, United States, Intitute Rene Rachou- 3 Susan Charman3, Karen White3, Robert Don4, Thomas W. von Geldern5 IRR, Belo Horizonte-Minas Gerais, Brazil, Institute Rene Rachou-IRR, Belo Horizonte- 1Epichem Pty Ltd., Murdoch, Australia, 2Murdoch University, Murdoch, Australia, Minas Gerais, Brazil 3Monash University, Parkville, Australia, 4Drugs for Neglected Diseases initiative, (ACMCIP Abstract) Geneva, Switzerland, 5Embedded Consulting, Richmond, IL, United States 756 11:45 a.m. MICROGEOGRAPHICAL ANALYSIS OF GENETIC 752 STRUCTURE AND REINFESTATION DYNAMICS OF TRIATOMA INFESTANS POPULATIONS IN NORTHERN TRANSPORT OF PENTAMIDINE AND FURAMIDINE IN ARGENTINA RAT AND HUMAN HEPATOCYTES Paula L. Marcet1, Matias S. Mora2, Ana P. Cutrera2, Ricardo E. Gürtler3, Xin Ming, Qiang Liu, Richard R. Tidwell, James E. Hall, Michael Z. Wang Uriel Kitron4, Ellen Dotson1 University of North Carolina at Chapel Hill, Chapel Hill, NC, United States 1Centers for Disease Control and Prevention- DPD- Entomology, Chamblee, GA, United (ACMCIP Abstract) States, 2Lab Ecofi siología-FCEN-Univ Mar del Plata, Mar del Plata, Argentina, 3Lab. Eco-epidemiología - FCEN-UBA, Buenos Aires, Argentina, 4Department of Environmental Studies, Emory University, Atlanta, GA, United States Exhibit Hall Open/Light Lunch 757 Exhibit Hall A Saturday, November 21, Noon - 1:30 p.m. A RAPID ASSAY FOR THE DETECTION OF ALL FOUR DENV SEROTYPES IN MOSQUITOES Poster Session 133/Light Lunch Maria E. Mayda1, Zahra Parker1, Kirti Dave2, Michael J. Turell3, Tobin Rowland1, Russell Coleman4, Daniel Strickman5 Poster Session C (#753 – 1005 and Late Breakers) 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2VecTOR Test Systems, Inc, Thousand Oaks, CA, United States, 3Virology Division, United States Exhibit Hall B South Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, United States, 4United States Army Medical Materiel Development Activity, Fort Detrick, MD, Saturday, November 21, Noon - 1:30 p.m. United States, 5Veterinary, Medical, and Urban Entomology, USDA, ARS, Beltsville, MD, United States ARTHROPODS/ENTOMOLOGY - OTHER 758

753 CHARACTERIZATION OF HEMOCYTES FROM AEDES AEGYPTI AND AEDES ALBOPICTUS

1 2 1 RESPONSE OF HUMAN SKIN EQUIVALENTS TO Luiz C. Alves , Helena R. Araújo , Fabio A. Baryner-Santos , Paulo F. Saturday, November 21 SARCOPTES SCABIEI MITES AND EXTRACT Pimenta3 Marjorie S. Morgan, Larry G. Arlian 1National Institutes of Health, Rockville, MD, United States, 2Institute Rene Rachou, Wright State University, Dayton, OH, United States Belo Horizonte-Minas Gerais, Brazil, 3Intitute Rene Rachou, Belo Horizonte-Minas (ACMCIP Abstract) Gerais, Brazil (ACMCIP Abstract)

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EVALUATION RESTING BEHAVIOR OF AEDES AEGYPTI A RETROSPECTIVE ANALYSIS OF HEALTH AND USING MARK-RELEASE-RECAPTURE DESIGN AND SCHOOL OUTCOMES OF A SCHOOL BASED MALARIA EXPERIMENTAL HUTS, PERU PROGRAMME IN MANGOCHI DISTRICT, MALAWI Fanny Castro-Llanos1, Hortance Manda2, Amy Morrison1, Victor Lopez1, Bertha Nhlema Simwaka Nichole L. Achee2, John P. Grieco2, Kirk Mundal1 Malaria Control and Evaluation Partnership for Africa Learning Community, Lusaka, 1Naval Medical Research Center, Iquitos, Peru, 2Uniformed Services University of the Zambia Health Sciences, Bethesda, MD, United States 766 760 DETECTION OF ENTAMOEBA HISTOLYTICA, GIARDIA ORAL-MEDIATED GENE SILENCING OF A FAT BODY INTESTINALIS AND CRYPTOSPORIDIUM SPP. ANTIGEN BY GENE OF RHODNIUS PROLIXUS USE OF LUMINEX XMAP TECHNOLOGY Pamela Pennington, Mabel Taracena, Claudia Umaña, Ana L. de Rashidul Haque1, Zannatun Noor1, Mamun Kabir1, Dinesh Mondal1, Li Montenegro, Celia Cordón-Rosales Chen2, Joel Herbein2, William A. Petri, Jr.3 Universidad del Valle de Guatemala, Guatemala, Guatemala 1International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, 2TechLab, Inc., Blacksburg, VA, United States, 3University of Virginia, Charlottesville, 761 VA, United States

EHRLICHIAE AND SPOTTED-FEVER GROUP RICKETTSIAE 767 IN TICKS FROM TENNESSEE Sara Cohen1, Michael Yabsley2, James Freye3, Brett Dunlap3, Junjun Huang1, LABORATORY CONFIRMED DIAGNOSES OF ACUTE Meghan Rowland1, Daniel Mead2, John Dunn1, Timothy Jones1, Abelardo C. FEBRILE ILLNESS IN GHANA Moncayo1 Karl C. Kronmann1, Guillermo Pimentel2, Naiki Puplampu3, Shirley Odoom3, 1Tennessee Department of Health, Nashville, TN, United States, 2University of Georgia, Janice Tagoe3, Edward Nyarko4, Prince Agbenohevi4, Gregory Raczniak1, Athens, GA, United States, 3United States Department of Agriculture, Animal and Plant Jamal Dejli2, Michael Wilson3, Kwadwo Koram3 Health Inspection Service, Wildlife Services, Madison, TN, United States 1Naval Medical Research Unit No. 3, Ghana Detachment, Accra, Ghana, 2Naval Medical Research Unit No. 3, Cairo, Egypt, 3Noguchi Memorial Institute for Medical Research, 762 Legon, Ghana, 437th Military Hospital, Accra, Ghana

DEMONSTRATION OF PARATRANSGENIC PHLEBOTOMUS 768 ARGENTIPES Heidi Hillesland1, Ivy Hurwitz1, Rajesh Kumar2, Ravi Durvasula1, Vijay ETIOLOGY OF FEBRILE DIARRHEA IN PERÚ AND Kumar2, Pradeep Das2, Annabeth Fieck1 PARAGUAY, 2001-2009 1University of New Mexico, Albuquerque, NM, United States, 2Rajendra Memorial Ryan C. Maves1, David Cepeda1, Michael J. Gregory1, Maria Bernal1, Rosa Research Institute of Medical Sciences, Patna, India Burga2, Jessica Vasquez2, Juan Perez1, Nicolas Aguayo3, Victor R. Ocaña4, Eduardo Gotuzzo5, Eric R. Hall6, Tadeusz J. Kochel1 763 1United States Naval Medical Research Center Detachment - Peru, Lima, Peru, 2United States Naval Medical Research Center Detachment - Peru, Iquitos, Peru, 3Rayos del Sol, PROMISING STRATEGY FOR VISCERAL LEISHMANIASIS Asuncion, Paraguay, 4Centro de Salud I 4 Pachitea, Piura, Peru, 5Universidad Peruana Cayetano Heredia, Lima, Peru, 6 United States Naval Medical Research Center, Silver CONTROL UTILIZING NANOPARTICLE DELIVERY OF Spring, MD, United States EFFECTOR MOLECULES Heidi Hillesland1, Scott Matthews1, Rajesh Kumar2, Ivy Hurwitz1, Annabeth 769 Fieck1, Ravi Durvasula1, Gabriel Lopez1, Pradeep Das2, Vijay Kumar2 1 2 University of New Mexico, Albuquerque, NM, United States, Rajendra Memorial CHILDHOOD KWASHIORKOR IN MADAGASCAR: A CASE Research Institute of Medical Sciences, Patna, India REPORT Gurpreet K. Bedi, Lesley A. Reid, Richard Roach CLINICAL TROPICAL MEDICINE Michigan State University Kalamazoo Center for Medical Studies, Kalamazoo, MI, United States 764 770 CLINICAL FACTORS CORRELATED TO IMMIGRANT SCREENING IN THE INPATIENT SETTING POSITIVE SEROLOGIC TEST IN MENINGITIC IN A MUNICIPAL HOSPITAL ANGIOSTRONGYLIASIS An Na Park1, Aaron Storms1, Jonathan Wiesen1, Phyllis Andrews1, Herbert Kanlayanee Sawanyawisuth, Kittisak Sawanyawisuth B. Tanowitz2, Christina M. Coyle2 Khon Kaen University, Khon Kaen, Thailand 1Jacobi Medical Center, Bronx, NY, United States, 2Albert Einstein College of Medicine, Bronx, NY, United States

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VARICELLA STATUS IN TRAVELERS SEEN IN THE AGGREGATE ECONOMIC COST OF DENGUE IN PUERTO BOSTON AREA TRAVEL MEDICINE NETWORK (BATMN) RICO Winnie W. Ooi Donald S. Shepard1, Yara A. Halasa1, Migda Dieppa1, Carmen L. Pérez- Lahey Clinic Medical Center, Burlington, MA, United States Guerra2 1Brandeis University, Waltham, MA, United States, 2Centers for Disease Control, San 772 Juan, PR, United States

PREVALENCE OF PLASMODIUM FALCIPARUM INFECTION 778 AMONG PATIENTS WITH CHRONIC RENAL FAILURE (CRF) IN MALI EFFECT OF METYLPREDNISOLONE IN PREVENTING DENGUE COMPLICATIONS: A SINGLE-CENTER Sahare Fongoro1, Nyangui B. Mwetse1, Ousmane A. Koita2, Mamadou W. Bagayoko3, Donald J. Krogstad4 RANDOMIZED PLACEBO-CONTROLLED TRIAL 1Hopital Point G and the Faculty of Medicine, University of Bamako, Bamako, Mali, Luis Angel Villar1, Ruth Aralí Martínez1, Fredi Alexander Díaz1, Juan Carlos 2Faculties of Science and Medicine, University of Bamako, Bamako, Mali, 3Faculty of Villar2, Ernesto Rueda1 Science, University of Bamako, Bamako, Mali, 4Tulane University Health Sciences 1Universidad Industrial de Santander, Bucaramanga, Colombia, 2Infovida, Center, New Orleans, LA, United States Bucaramanga, Colombia

773 779

LEPTOSPIROSIS IN THE REPUBLIC OF GEORGIA NATURAL STRAIN VARIATION AND THE Danielle V. Clark1, Tinatin Kuchuloria2, Tamuna Akhvlediani2, Matthew NEUTRALIZATION OF DENGUE SEROTYPE 3 VIRUSES J. Hepburn3, Guillermo Pimentel4, Maiko Chokheli5, Nana Mamuchishvili5, WMPB Wahala1, Eric Donaldson2, Yang Zhou1, Ralph Baric2, Aravinda M. Paata Imnadze5 de Silva1 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2Technology 1University of North Carolina School of Medicine, Chapel Hill, NC, United States, Management Company, Tbilisi, Georgia, 3United States Army Medical Research 2University of North Carolina School of Public Health, Chapel Hill, NC, United States Institute of Infectious Diseases, Fort Detrick, MD, United States, 4United States Naval Medical Research Unit #3, Cairo, Egypt, 5National Center for Disease Control and Public 780 Health, Tbilisi, Georgia

774 PAEDIATRIC DENGUE SURVEILLANCE IN COLOMBO, SRI LANKA CANDIDAEMIA IN A TERTIARY CARE HOSPITAL IN Hasitha Tissera1, Nihal Abeysinghe2, Aravinda M. de Silva3, WMPB 3 1 4 5 KOLKATA, INDIA Wahala , Paba Palihawadana , Clarence Tam , Sunethra Gunasena , Dharshan de Silva6, Thilini de Silva6, Dammika Seneviratne6, Ananda Saikat Basu, Satadal Das Amarasinghe7, W. William Letson7, Harold Margolis7 Peerless Hospital and B. K. Roy Research Centre, Kolkata, India 1Epidemiology Unit, Ministry of Health, Sri Lanka, 2Ministry of Health, Colombo, Sri Lanka, 3University of North Carolina School of Medicine, Chapel Hill, NC, United FLAVIVIRIDAE - DENGUE States, 4London School of Hygiene and Tropical Medicine, London, United Kingdom, 5Medical Research Institute, Colombo, Sri Lanka, 6Genetech Research Institute, Colombo, Sri Lanka, 7Pediatric Dengue Vaccine Initiative, Seoul, Republic of Korea 775 781 DENGUE AMONG PATIENTS WITH UNDIFFERENTIATED FEVER IN SOUTHERN SRI LANKA DETECTION OF ASYMPTOMATIC INFECTION AMONG RELATIVES OF DENGUE PATIENTS Megan E. Reller1, Champika Bodinayake2, Ajith Nagahawatte2, Vasantha Devasiri2, Wasantha Kodikara-Arachchi2, Anne Broadwater3, John J. Mariana C. Sobral, Luiza A. Castro-Jorge, Luzia M. Passos, Rosana Moreira Strouse1, Christopher W. Woods4, Aravinda M. de Silva3 Oliveira, Benedito A. Fonseca 1Johns Hopkins Medical Institutions, Baltimore, MD, United States, 2University of School of Medicine of Ribeirão Preto, Ribeirão Preto, S.P., Brazil Ruhuna, Galle, Sri Lanka, 3University of North Carolina, Chapel Hill, NC, United States, 4Duke University, Durham, NC, United States 782

776 INVESTIGATING NOVEL DENGUE VIRUS INFECTION BIOMARKERS USING PROTEOMIC METHODS: Saturday, November 21 COST OF DENGUE VECTOR CONTROL ACTIVITIES IN VITRONECTIN PRECURSOR PROTEIN AS A NEW LEAD PUERTO RICO Alexa Gilbert1, Takol Takol Chareonsirisuthigul2, Sukathida Ubol2, Brian J. Carmen L. Pérez-Guerra1, Kay Tomashek1, Reinaldo Rivera1, Marisol Peña1, Ward1, Momar Ndao1 Yara A. Halasa2, Donald S. Shepard2 1McGill University, Montreal, QC, Canada, 2Mahidol University, Bangkok, Thailand 1Centers for Disease Control, San Juan, PR, United States, 2Brandeis University, (ACMCIP Abstract) Waltham, MA, United States

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783 789

BABOON MODEL FOR DENGUE VIRUS INFECTION AND DENGUE TRENDS BY AGE AND SEX IN PUERTO RICO A VACCINE EVALUATION HISTORICAL ANALYSIS FROM 1990 TO 2008 James F. Papin1, Roman F. Wolf1, Isaac B. Hilton2, Anne Broadwater2, Marisol Peña-Orellana1, Jose M. Calderón-Squiabro1, Rosa Rodríguez1, Aravinda M. de Silva2, Gary L. White1, Dirk P. Dittmer2 Fermín Argüello1, Gustavo Dayan2, Kay Tomashek1 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States, 1Centers for Disease Control and Prevention, San Juan, PR, United States, 2Sanofi - 2University of North Carolina Chapel Hill, Chapel Hill, NC, United States Pasteur, Swiftwater, PA, United States

784 790

SEROPREVALENCE OF DENGUE IN UNITED STATES CHARACTERIZATION OF A PANEL OF DENV-3 ARMY SPECIAL OPERATIONS COMMAND PERSONNEL INFECTIOUS CLONES Jennifer B. Caci1, Danielle M. Tack2, Arthur Lyons3 William Messer1, Boyd Yount2, Eric Donaldson2, Kari Hacker3, Wahala 1United States Army Special Operations Command, Fort Bragg, NC, United States, Wahala3, Mary Ann Accavitti4, Aravinda de Silva3, Ralph Baric2 298th Civil Affairs Battalion, Fort Bragg, NC, United States, 3Walter Reed Army 1University of North Carolina School of Medicine, Department of Medicine, Division Institute of Research, Silver Spring, MD, United States of Infectious Diseases, Chapel Hill, NC, United States, 2University of North Carolina School of Public Health, Department of Epidemiology, Chapel Hill, NC, United States, 785 3University of North Carolina School of Medicine, Department of Microbiology and Immunology, Chapel Hill, NC, United States, 4University of Alabama, Department of Genetics, Birmingham, AL, United States MOLECULAR DETERMINANTS OF DENGUE VIRUS ENVELOPE PROTEIN IN VIRUS INFECTION 791 Claire Y. Huang1, Siritorn Butrapet2, Steven M. Erb2, Kelly Moss1, Amanda 1 1 1 2 Calvert , Richard M. Kinney , John T. Roehrig , Carol D. Blair TOWARDS DEVELOPING AN ANIMAL MODEL 1Centers for Disease Control and Prevention, Fort Collins, CO, United States, 2Colorado State University, Fort Collins, CO, United States TO EVALUATE THE PROTECTIVE EFFICACY OF ANTIBODIES RAISED AGAINST CANDIDATE DENGUE 786 VACCINES Charalambos D. Partidos1, Joseph N. Brewoo1, Shawn J. Shilengo2, Tim PHENOTYPIC ANALYSIS OF DENGUE VIRUS ISOLATES D. Powell2, Claire Y.H. Huang3, Richard M. Kinney2, Dan T. Stinchcomb2, ASSOCIATED WITH DENGUE FEVER AND DENGUE Jorge E. Osorio4 1Inviragen, Inc., Madison, WI, United States, 2Inviragen, Inc., Fort Collins, CO, United HEMORRHAGIC FEVER FOR CELLULAR ATTACHMENT, States, 3Division of Vector-Borne Infectious Diseases, Centers for Disease Control and REPLICATION AND INTERFERON SIGNALING ABILITY Prevention, Fort Collins, CO, United States, 4University of Wisconsin, Madison, WI, Ratree Takhampunya11, Dupeh R. Palmer11, David A. David A. Barvir11, United States Julia Lynch1, Richard G. Jarman2, Stephen Thomas1, Robert V. Gibbons2, Robert Putnak1, Chunlin Zhang1 792 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand IMMUNE-SUPPRESSIVE ABILITY OF DENGUE VIRUS IN AEDES AEGYPTI 787 AN CELL LINE Shuzhen Sim, Jose L. Ramirez, Jayme A. Souza-Neto, George Dimopoulos Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States NEEDLE-FREE DELIVERY OF A TETRAVALENT DENGUE VACCINE (DENVAX): SAFETY AND EFFICACY IN NON- 793 HUMAN PRIMATES Joseph N. Brewoo1, Michael A. Royals2, John J. Arguello3, Shawn J. KINETIC ASSESSMENT OF DENGUE VIRUS CELLULAR 3 3 1 3 Silengo , Tim D. Powell , Charalambos D. Partidos , Richard M. Kinney , TROPISM Claire Y. Huang4, Jorge E. Osorio5, Dan T. Stinchcomb3 1Inviragen, Inc., Madison, WI, United States, 2PharmaJet, Inc., Golden, CO, United Tyler R. Prestwood, Sujan Shresta States, 3Inviragen, Inc., Fort Collins, CO, United States, 4Division of Vector-Borne La Jolla Institute for Allergy and Immunology, La Jolla, CA, United States Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, United States, 5University of Wisconsin, Madison, WI, United States 794

788 FREQUENCY OF DENGUE FEVER AMONG FEBRILE PATIENTS PRESENTING TO AN URBAN HOSPITAL IN INHIBITION OF THE TYPE I IFN PRODUCTION IN MEDELLIN, COLOMBIA: STUDY RESULTS DENDRITIC CELLS BY DENGUE VIRUS Jorge E. Osorio1, Mark E. Beatty2, Yenny Goez3, Lina Restrepo3, Ruth E. Juan R. Rodriguez-Madoz1, Dabeiba Bernal-Rubio1, Alan Belicha- Ramirez3, Francisco J. Diaz4, Berta N. Jaramillo3 Villanueva1, Jorge Munoz-Jordan2, Adolfo Garcia-Sastre1, Ana Fernandez- 1University of Wisconsin, Madison, WI, United States, 2Pediatric Dengue Vaccine Sesma1 Initiative, International Vaccine Institute, Seoul, Republic of Korea, 3Instituto 1Mount Sinai School of Medicine, New York, NY, United States, 2Centers for Disease Colombiano de Medicina Tropical, Universidad CES, Sabaneta, Colombia, 4Universidad Control and Prevention, San Juan, PR, United States de Antioquia, Medellin, Colombia

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795 801

USE OF AG129 MICE TO ASSESS THE SAFETY OF LIVE, USE OF HAND HELD COMPUTERS FOR PRIMARY DATA ATTENUATED DENGUE VACCINES COLLECTION IN A DENGUE FEVER SURVEILLANCE Richard M. Kinney1, John J. Arguello1, Shawn J. Silengo1, Richard A. STUDY, MEDELLIN, COLOMBIA Bowen2, Claude A. Piche3, Claire Y. Huang4, Dan T. Stinchcomb1, Jorge E. Mark E. Beatty1, Daniel Perez1, Yenny Goez Rivillas2, Bertha Nelly Restrepo Osorio5 Jaramillo2, Jorge E. Osorio3 1Inviragen, Inc., Fort Collins, CO, United States, 2Colorado State University, Fort 1International Vaccine Institute, Seoul, Republic of Korea, 2Instituto Colombiano Collins, CO, United States, 3Promesa Bio, LLC, Fort Collins, CO, United States, de Medicina Tropical, Universidad CES, Sabaneta, Colombia, 3Department of 4Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Fort Collins, CO, United States, 5Inviragen, Inc., Madison, WI, United States Madison, WI, United States

796 802

SUSCEPTIBLE RECONSTRUCTION AND SEROTYPE EPIDEMIOLOGIC CONDITIONS ASSOCIATED SPECIFIC ESTIMATES OF THE TRANSMISSIBILITY WITH CASES OF DENGUE HEMORRHAGIC FEVER AND SEASONALITY OF TRANSMISSION OF DENGUE AND CONTROL EFFORTS: APPLYING TAIWAN’S VIRUSES IN THAILAND EXPERIENCES TO GLOBAL CONTROL Jon D. Benenson1, Robert V. Gibbons2, Ananda Nisalak2, Siripen Chwan-Chuen King1, Tzai-Hung Wen1, Day-Yu Chao1, Scott Yan-Jang Kalayanarooj S.3, Derek A. Cummings1 Huang2, Shu-Fang Chuang3, Cheng-Jung Lee1, Chuan-Liang Kao3 1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 1Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, 2Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand, 3Queen Sirikit Taiwan, 2Department of Public Health, College of Public Health, National Taiwan National Institute of Child Health, Bangkok, Thailand University, Taipei, Taiwan, 3Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan 797 803 DENGUE INFECTION IN HOSPITALIZED PATIENTS WITH FEBRILE SYNDROME, MEDELLIN, COLOMBIA DENGUE IN CEBU PROVINCE FOR OVER A DECADE Berta N. Restrepo1, Mark E. Beatty2, Yenny Goez1, Lina Restrepo1, Jorge E. AND PUPAL PRODUCTIVITY OF DENGUE MOSQUITO Osorio3 VECTORS (DIPTERA: CULICIDAE) IN A RURAL AREA IN 1Instituto Colombiano de Medicina Tropical, Universidad CES, Sabaneta, Colombia, CEBU, PHILIPPINES 2 Pediatric Dengue Vaccine Initiative, International Vaccine Institute, Seoul, Republic of 1 1 1 Korea, 3University of Wisconsin, Madison, WI, United States Frances E. Edillo , Nenito D. Otero II , Noel D. Roble , Susana K. Madarieta2 1University of San Carlos, Cebu City, Philippines, 2Department of Health, Region VII, 798 Cebu City, Philippines

USEFULNESS OF COMMERCIALLY AVAILABLE GPS DATA-LOGGERS FOR TRACKING HUMAN MOVEMENT FLAVIVIRIDAE - OTHER AND RISK OF DENGUE VIRUS INFECTION Gonzalo M. Vazquez-Prokopec1, Steven Stoddard2, Valerie Paz-Soldan3, 804 Amy Morrison2, Jorge Vasquez-Belchoir2, John Elder4, Thomas W. Scott2, Uriel Kitron1 ACUTE ENCEPHALITIS SYNDROME SURVEILLANCE 1 2 Emory University, Atlanta, GA, United States, University of California, Davis, CA, FOR JAPANESE ENCEPHALITIS --- INDIA, MAY United States, 3Tulane University, New Orleans, LA, United States, 4San Diego State University, San Diego, CA, United States 2007-APRIL 2008 Adrianne E. Sever1, Anindya S. Bose2, Marc Fischer1, GPS Dhillon3, 799 Barbara W. Johnson1, Jamie S. Robinson1, V. Ravi Vasanthapuram4, Nalini Ramamurty5, Anita Desai4, Hamid S. Jafari2, Hardeep S. Sandhu1 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2World Health DENGUE SURVEILLANCE IN A TERTIARY HOSPITAL IN Organization/National Polio Surveillance Project-India, Delhi, India, 3National Vector- CEBU CITY, PHILIPPINES Borne Disease Control Programme, Delhi, India, 4National Institute of Mental Health Maria Theresa P. Alera and Neurological Sciences, Bangalore, India, 5World Health Organization-South-East United States Army Medical Component-Armed Forces Research Institute of Medical Asia Regional Offi ce, New Delhi, India Sciences, Bangkok, Thailand 805 800 Saturday, November 21 IN SITU REVERSE-TRANSCRIPTION LOOP-MEDIATED ESTIMATING THE GLOBAL BURDEN OF DENGUE ISOTHERMAL AMPLIFICATION (IN SITU RT-LAMP) FOR Mark E. Beatty, G. William Letson, Harold S. Margolis DETECTION OF JAPANESE ENCEPHALITIS VIRAL RNA International Vaccine Institute, Seoul, Republic of Korea IN HOST CELLS Yi Liu, Ching-Kai Chuang, Wei-June Chen Chang Gung University, Tao-Yuan, Taiwan

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806 FLAVIVIRIDAE – WEST NILE

DEVELOPMENT OF A CONSENSUS MICROARRAY METHOD FOR IDENTIFICATION OF SOME SEVERE 811 INFECTIVE VIRUSES DEVELOPMENT OF A BROAD SPECTRUM FLAVIVIRUS Yang Y. Yinhui, Kang X. Xiaoping, Jiang Y. Yongqiang, Sun Qing-Ge, Liu QUANTITATIVE DETECTION ASSAY USING Hong, Zhu Qing-Yu Institute of Microbiology and Epidemiology, Beijing, China, Beijing, China RT-PCR/ELECTROSPRAY IONIZATION MASS SPECTROMETRY ON THE IBIS T5000 PLATFORM 807 Rebecca J. Grant1, Carson D. Baldwin1, Michael J. Turell1, Cindy Rossi1, Feng Li2, Robert Lovari2, Larry Blyn2, Ranga Sampath2, Chris A. Whitehouse1 THE CHANGE OF THE HSP70-RELATED GENES AND 1United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, 2 ITS POTENTIAL ROLE IN C6/36 CELL INFECTED BY United States, Ibis Biosciences, Carlsbad, CA, United States JAPANESE ENCEPHALITIS VIRUS 812 Ching-kai Chuang, Wei-June Chen Chang Gung University, Tao-Yuan, Taiwan DETECTION OF WEST NILE VIRUS RNA BY ONE-STEP 808 REAL TIME RT-PCR Kenan Sener1, Mehmet Yapar1, Aykut Ozkul2, Ozgur Koru1, Ayhan Kubar1 1 2 DIFFERENTIAL INTERACTION OF DENDRITIC CELLS Gulhane Military Medical Academy, Ankara, Turkey, Faculty of Veterinary, University of Ankara, Ankara, Turkey AND MACROPHAGES TO RUSSIAN SPRING-SUMMER ENCEPHALITIS AND OMSK HEMORRHAGIC FEVER 813 VIRUSES Bersabeh Tigabu, Michael Holbrook A CPE BASED HIGH THROUGHPUT SCREEN FOR ANTI- University of Texas Medical Branch, Galveston, TX, United States WEST NILE VIRUS: MLPCN CAMPAIGN 809 Dong Hoon Chung, Blake Moore, Fuli Jia, Shuang Feng, Clinton Maddox, Rasmussen Lynn, E. Lucile White, Melinda I. Sosa, Colleen B. Jonsson Southern Research Institute, Birmingham, AL, United States DETECTION AND CHARACTERIZATION OF TICK-BORNE ENCEPHALITIS VIRUS AND ITS RESERVOIR IN THE HELMINTHS – NEMATODES – FILARIASIS KYRGYZ REPUBLIC (OTHER) Benjamin J. Briggs1, Donna M. Czechowski1, Peter A. Larsen2, Heather N. Meeks2, Juan P. Carrera2, Vicki J. Swier2, Barry Atkinson3, Roger Hewson3, Asankadyr T. Junushov4, Olga N. Gavrilova5, Irena Breininger5, Carlton J. 814 Phillips2, Robert J. Baker2, John Hay1 1University at Buffalo, Buffalo, NY, United States, 2Texas Tech University, Lubbock, TX, United States, 3Health Protection Agency, Porton Down, United Kingdom, 4National A MULTICENTER EVALUATION OF A NEW ANTIBODY Academy of Sciences of the Kyrgyz Republic, Bishkek, Kyrgyzstan, 5Ministry of TEST KIT FOR LYMPHATIC FILARIASIS EMPLOYING Healthcare of the Kyrgyz Republic, Bishkek, Kyrgyzstan RECOMBINANT BRUGIA MALAYI ANTIGEN BM-14 Kurt C. Curtis1, Peter U. Fischer1, Kimberly Y. Won2, Patrick J. Lammie2, 810 Hayley M. Joseph3, Wayne D. Melrose3, Norbert W. Brattig4, Gary J. Weil1 1Washington University School of Medicine, St. Louis, MO, United States, 2Centers for JAPANESE ENCEPHALITIS IN THE PHILIPPINES: Disease Control and Prevention, Atlanta, GA, United States, 3James Cook University, CHART REVIEW AND LABORATORY CONFIRMED Townsville, Australia, 4Bernhard Nocht Institute for Tropical Medicine, Hamburg, HOSPITALIZED CASES Germany Maria Theresa P. Alera 815 United States Army Medical Component-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand SOCIO-ECONOMIC ANALYSIS OF NTD AT INDIVIDUAL AND HOUSEHOLD LEVEL: SELECTED EVIDENCES, KNOWLEDGE GAPS AND ALTERNATIVE PATTERNS OF IMPACT ASSESSMENT Elena Vuolo World Health Organizarion Eastern Mediterranean Offi ce, Cairo, Egypt

816

NOVEL BORON-CONTAINING SMALL MOLECULES AS POTENTIAL THERAPEUTICS AGAINST HUMAN LYMPHATIC FILARIASIS Yvonne R. Freund1, Yong-Kang Zhang1, Vincent Hernandez1, Liang Liu1, Lisa Feng1, Jessica Kopaczewski2, Michael A. Kron2 1Anacor Pharmaceuticals, Inc., Palo Alto, CA, United States, 2Medical College of Wisconsin, Milwaukee, WI, United States

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817 823

OPTIMISING ANTIBIOTIC TREATMENT OF BRUGIA STATUS OF NEGLECTED TROPICAL DISEASES IN MALAYI WOLBACHIA IN INFECTED JIRDS MOROGORO REGION, TANZANIA MAINLAND Louise Ford1, Ana Guimaraes1, John W. McCall2, Mark J. Taylor1 Upendo J. Mwingira1, Benjamin Mayalla1, Bernard Kilembe1, William 1A-WOL Consortium, Filariasis Research Group, Liverpool School of Tropical Medicine, Kisoka1, Mbutolwe E. Mwakitalu1, Nicholas Lwambo2, Prince Mutalemwa1, Liverpool, United Kingdom, 2Department of Infectious Diseases, College of Veterinary Charles D. Mackenzie3, Lynsey Blair4, Allan Fenwick4, Edwin Michael4, Medicine, University of Georgia, Athens, GA, United States Mwele N. Malecela1 1National Institute for Medical Research, Dar-es-salaam, United Republic of Tanzania, 818 2National Institute for Medical Research, Mwanza, United Republic of Tanzania, 3Michigan State University, East Lansing, MI, United States, 4Imperial College School of Medicine, London, United Kingdom PROSPECTS FOR THE INTERRUPTION OF ONCHOCERCIASIS TRANSMISSION IN MOUNT ELGON 824 FOCUS, EASTERN UGANDA Frank Richards1, Tom Lakwo2, Peace Habomugisha3, Ephraim Tukesiga2, THE NEMATODE PARASITE ONCHOCERCA VOLVULUS AND 3 2 2 3 Stella Agunyu , David Ogutu , John Bosco Rwakimari , Edson Byamukama , OTHER FILARIAE GENERATE THE TRANSFORMING D. K. Lwamafa2, Sam Zaramba2, Donald Hopkins1, Lindsay Rakers1, Moses Katabarwa1 GROWTH FACTOR-BETA (TGF-BETA) 1Emory University/The Carter Center, Atlanta, GA, United States, 2Ministry of Health, Simone Korten1, Dietrich W. Büttner1, Christel Schmetz1, Achim Hoerauf2, Kampala, Uganda, 3The Carter Center, Kampala, Uganda Sabine Mand2, Norbert Brattig1 1Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, 2Institute for 819 Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany COST-EFFECTIVENESS ANALYSIS OF MICROSCOPY, (ACMCIP Abstract) OG4C3 ELISA AND PCR FOR THE MONITORING OF 826 LYMPHATIC FILARIASIS MASS DRUG ADMINISTRATION INTERVENTION DEVELOPMENT OF GMP PROTOCOL FOR THE Vida E. Hotor1, Michael D. Wilson1, Moses Aikins2, Charles Brown1, Daniel PRODUCTION OF R-BM14 BASED IGG4 ELISA KIT A. Boakye1, Langbong Bimi3 1Noguchi Memorial Institute for Medical Research, Accra, Ghana, 2School of Public Diane Dogcio Health, University of Ghana, Accra, Ghana, 3Zoology Department, University of Ghana, Cellabs Pty Ltd., Brookvale, Australia Accra, Ghana (ACMCIP Abstract) KINETOPLASTIDA – DIAGNOSIS AND 820 TREATMENT

STRUCTURAL AND IMMUNOLOGIC CROSS REACTIVITY 827 AMONG ALLERGENS AND HOMOLOGOUS HELMINTH ANTIGENS: LESSONS LEARNED FROM TROPOMYOSIN CONGENITAL TRANSMISSION OF TRYPANOSOMA CRUZI AND THEIR IMPLICATION FOR THE HYGIENE IN SECOND GENERATION WISTAR RATS HYPOTHESIS Elio Moreno, Marta Ramirez, Maritza Alarcon, Ana Lugo-Yarbuh, Juana Helton C. Santiago, Sasisekhar Bennuru, Thomas Nutman Villarreal, Anajulia Gonzalez National Institutes of Health, Bethesda, MD, United States Universidad de Los Andes, Merida, Venezuela (ACMCIP Abstract) 828

821 IMPORTANCE OF URINARY KINETIC TO VALUE THE DISPOSITION OF EXPERIMENTAL PENTAVALENT NATURAL PROGRESSION OF LYMPHEDEMA IN TOGO ANTIMONY ULAMINA® BETWEEN 2004 AND 2007 Laura C. Vasquez1, Libia R. Vasquez1, Milagros Oviedo2, Jose V. Scorza D3, Hashini Seneviratne1, Jennifer Lasley1, Stephanie Richard1, Ameyo M. Nelson Vicuña-Fernandez1, Yaneira Petit de Peña3 Dorkenoo2, Yao Sodahlon3, Els Mathieu1 1Universidad de Los Andes, Valera, Venezuela, 2Instituto Experimental Jose W. 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Ministry of Torrealba Universidad de Los Andes, Trujillo, Venezuela, 3Universidad de Los Andes, 3

Health, Lome, Togo, Mectizan Donation Program, Atlanta, GA, United States Merida, Venezuela Saturday, November 21

822

EVALUATION OF THE LARVAL MIGRATION INHIBITION ASSAY FOR DETECTING IVERMECTIN RESISTANCE IN BRUGIA PAHANGI Christopher C. Evans, Michael T. Dzimianski, Andy R. Moorhead, Ray M. Kaplan University of Georgia, Athens, GA, United States

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829 834

LEAD OPTIMIZATION OF NOVEL BORON-CONTAINING A NEW PEDIATRIC TABLET STRENGTH OF DRUG CANDIDATES FOR THE TREATMENT OF HUMAN BENZNIDAZOLE FOR THE TREATMENT OF CHAGAS AFRICAN TRYPANOSOMIASIS DISEASE Robert Jacobs1, Charles Ding2, Yvonne Freund2, Kurt Jarnagin2, Jacob Dianne J. Terlouw1, Fabiana P. Alves2, Sergio Sosa-Estani3, Hector Freilij4, Plattner2, Cyrus Bacchi3, Nigel Yarlett3, Matthew Orr1, Bakela Nare1, Cindy Jaime Altcheh4, Laurent Brutus5, Jean-René Kiechel2, Isabela Ribeiro2 Rewerts1, Daitao Chen1, Andy Noe1, Jessica Sligar1, Matthew Jenks1, 1Liverpool School of Tropical Medicine (LSTM), Liverpool, United Kingdom, 2Drugs Stephen Wring1, Robert Don4 for Neglected Diseases initiative (DNDi), Geneva, Switzerland, 3Centro Nacional de 1SCYNEXIS, INC., Research Triangle Park, NC, United States, 2Anacor Diagnóstico e Investigación de Endemo-epidemias (CeNDIE) ANLIS Dr. Carlos G. Pharmaceuticals, Inc., Palo Alto, CA, United States, 3Pace University, New York, NY, Malbrán, Ministry of Health, Buenos Aires, Argentina, 4Hospital de Niños Ricardo United States, 4Drugs for Neglected Diseases initiative, Geneva, Switzerland Gutierrez, Buenos Aires, Argentina, 5IRD-UR010 Santé de la mère et de l’enfant en milieu tropical, Université Paris Descartes, Paris, France 830 835 COST-EFFECTIVENESS ANALYSIS OF COMBINATION THERAPIES FOR VISCERAL LEISHMANIASIS ON THE EVALUATION OF NEW TESTS FOR EARLY INDIAN SUBCONTINENT DIAGNOSIS OF VISCERAL LEISHMANIASIS AND ITS Filip Meheus1, Shyam Sundar2, Suman Rijal3, A. Faiz4, Manica Balasegaram5, COMPLICATIONS AT THE ‘POINT-OF-CARE’ Jorge Alvar6, Piero Olliaro6, Marleen Boelaert1 Kazi M. Jamil1, Abu Toha Bhuiyan1, Gulam M. Khan1, Mohammad S. Alam1, 1Institute of Tropical Medicine, Antwerp, Belgium, 2Banaras Hindu University, Rashidul Haque1, Makoto Itoh2, Eisei Noiri3, Stephen P. Luby1 Varanasi, India, 3BP Koirala Institute of Medical Sciences, Dharan, Nepal, 4Ministry 1International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, of Health and Family Welfare, Dhaka, Bangladesh, 5Drugs for Neglected Diseases 2Aichi Medical University, Nagakute, Aichi-ken, Japan, 3University of Tokyo, Tokyo, Initiative, Geneva, Switzerland, 6World Health Organization, Geneva, Switzerland Japan

831 836

LOOK TO THE LESION: SYSTEMIC ANTIMONIAL REVERSED AMIDINES AS ANTI LEISHMANIAL AGENTS: THERAPY DOES NOT CURE EARLY PREULCERATIVE IN VIVO EVALUATION OF CANDIDATE COMPOUNDS AMERICAN CUTANEOUS LEISHMANIASIS IN AGAINST VISCERAL LEISHMANIASIS IN HAMSTER NORTHEASTERN BRAZIL MODEL Alon Unger1, Paulo R. Machado2, Luiz H. Guimarães2, Olivia Bacellar2, Anuradha Srivastava, Brian Vesely, Dennis E. Kyle Albert Schreifer2, Marshall J. Glesby3, Edgar M. Carvalho2 University of South Florida, Tampa, FL, United States 1Departments of Medicine and Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States, 2Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil, 3Department of MALARIA – BIOLOGY AND Medicine, Weill Cornell Medical College, New York City, NY, United States PATHOGENESIS 832 837 EFFICACY OF MILTEFOSINE IN THE TREATMENT OF AMERICAN CUTANEOUS LEISHMANIASIS CAUSED BY L. HISTOPATHOLOGIC STUDIES IN DIFFERENT STRAINS BRAZILIENSIS IN BRAZIL OF SEMI IMMUNE MICE INFECTED WITH PBANKA AFTER CHRONIC EXPOSURE Paulo R.L. Machado1, Julia Ampuero1, Luiz Henrique S. Guimaraes1, Albert Schriefer1, Edgar M. Carvalho1, Sinésio Talhari2, Gerson O. Penna3 Gideon K. Helegbe, Tetsuo Yanagi, Masachika Senba, Nguyen T. Huy, 1Serviço de Imunologia, HUPES, Universidade Federal da Bahia, Salvador - BA, Brazil, Mohammed N. Shuaibu, Akiko Yamazaki, Mihoko Kikuchi, Michio 2Fundação de Medicina Tropical, Amazonas, Brazil, 3Universidade de Brasília - Nucleo Yasunami, Kenji Hirayama de Medicina Tropical, Brasília - DF, Brazil Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan

833 838

EVALUATION OF COMPOUNDS FOR CUTANEOUS ANALYSIS OF PLASMODIUM INFECTION IN CULTURED LEISHMANIAL ACTIVITY IN BALB/C MICE INFECTED ERYTHROPOIETIC CELLS WITH LEISHMANIA MAJOR Tetsuya Furuya1, Maki Touma2, Kenkichi Sugimoto2, Wu Ma1, Timothy 1 Arba Ager1, Bill Ellis2, Bill Ellis2, Juan Mendez2, Alan Magill2, Richard Stedman 1American Type Culture Collection, Manassas, VA, United States, 2Niigata University, Boodoo1, Jenbon Lui1, Max Grogl2 1University of Miami, Miami, FL, United States, 2Walter Reed Army Institute of Niigata, Japan Research, Silver Spring, MD, United States 839

EUROPEAN CONCERTED RESEARCH ACTION ON LIFE OR DEATH OF PROTOZOAN PARASITES Stephane Picot1, Sue Welburn2 1Malaria Research Unit, University Lyon 1, Lyon, France, 2College of Medicine and Veterinary Medicine, Edinburgh, United Kingdom

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FLUORESCENCE MULTIPLEXING IMAGING FOR ELEVATED TNF RECEPTOR 2 IS AN INDICATOR STUDYING PROTEIN TRAFFICKING IN PLASMODIUM OF PLACENTAL MALARIA BUT LEVELS DID NOT FALCIPARUM-INFECTED HUMAN ERYTHROCYTES CORRELATE WITH MALARIA-ASSOCIATED LOW BIRTH USING TETRACYSTEINE-TAGGED KNOB-ASSOCIATED WEIGHT BABIES PROTEINS Audrey D. Thévenon1, Rose G. Leke and the team at the Biotechnology Georgeta Crivat1, Juliana Martha Sa2, Jeeseong Hwang1, Fuyuki Center2, Diane Wallace Taylor1 Tokumasu2, Thomas E. Wellems2 1Georgetown University, Washington, DC, United States, 2University of Yaoundé 1, 1National Institutes of Health/NIST, Rockville, MD, United States, 2National Institutes Yaoundé, Cameroon of Health/National Institute of Allergy and Infectious Diseases, Rockville, MD, United (ACMCIP Abstract) States (ACMCIP Abstract) 847

841 MEROZOITE SURFACE PROTEIN 2 HAS A POTENTIAL ROLE IN THE ATTACHMENT OF PLASMODIUM METABOLOMIC ANALYSIS OF THE MALARIA PARASITE FALCIPARUM MEROZOITES TO ERYTHROCYTES DURING PLASMODIUM FALCIPARUM INVASION Viswanathan Lakshmanan1, Kyu Rhee2, Johanna Daily1 Jesse L. Schloegel1, Christopher G. Adda2, Fiona Durand2, Vince J. 1Albert Einstein College of Medicine, Bronx, NY, United States, 2Weill Cornell Medical Murphy2, Kleo Vingas3, Giuseppe D. Ciccotosto4, Roberto Cappai4, Barnham College, New York, NY, United States J. Kevin4, Michael Foley2, Robin F. Anders2 1University of South Florida, Tampa, FL, United States, 2Latrobe University, Victoria, 842 Australia, 3CRC for Vaccine Technology, Victoria, Australia, 4Department of Pathology, University of Melbourne and Mental Health Research Institute, Victoria, Australia DISRUPTION OF LIPOYLATION IN THE P. FALCIPARUM MITOCHONDRION AND APICOPLAST IS LETHAL 848 Maroya D. Spalding, Sean T. Prigge Johns Hopkins School of Public Health, Baltimore, MD, United States MODIFICATION OF CD47 LEVELS ON PLASMODIUM (ACMCIP Abstract) FALCIPARUM-INFECTED ERYTHROCYTES Kodjo Ayi1, Constance Finney1, W Conrad Liles2, Kevin K. Kain2 843 1Tropical Disease Unit, Sandra A. Rotman Laboratories, McLaughlin-Rotman Centre for Global Health, Toronto General Hospital-UHN, Toronto, ON, Canada, 2Tropical NITRIC OXIDE PROTECTION AGAINST CEREBRAL Disease Unit, Sandra A. Rotman Laboratories, McLaughlin-Rotman Centre for Global Health, Toronto General Hospital-UHN, McLaughlin Centre for Molecular Medicine; MALARIA IN MICE IS ASSOCIATED WITH IMPROVED Institute of Medical Sciences, Department of Medicine, University of Toronto, Toronto, CEREBRAL MICROCIRCULATORY PHYSIOLOGY ON, Canada Pedro Cabrales, Graziela M. Zanini, Diana Meays, John Frangos, Leonardo J. Carvalho 849 La Jolla Bioengineering Institute, La Jolla, CA, United States SERUM BUT NOT CEREBROSPINAL FLUID 844 ENDOTHELIN-1 LEVELS IN CHILDREN WITH CEREBRAL MALARIA ARE ASSOCIATED WITH NEUROLOGIC ASSOCIATION OF NITRIC OXIDE WITH HEME IN P. DEFICITS FALCIPARUM FOOD VACUOLES Gregory S. Park1, Kathleen Ireland1, Robert O. Opoka2, Michael J. Boivin3, 1 2 3 Graciela R. Ostera , Gudrun Lukat-Rodgers , Fuyuki Tokumasu , Sanjai Chandy C. John1 4 2 Kumar , Kenton Rodgers 1University of Minnesota, Minneapolis, MN, United States, 2Makerere University, 1 National Institutes of Health, Laboratory of Malaria and Vector Research, Rockville, Kampala, Uganda, 3Michigan State University, East Lansing, MI, United States MD, United States, 2North Dakota State University, Fargo, ND, United States, 3National Institutes of Health, Rockville, MD, United States, 4Center for Biologics Evaluation and Research, FDA, Rockville, MD, United States MALARIA - CHEMOTHERAPY

845 850 RELATIONSHIPS BETWEEN HEMOGLOBIN/RED BLOOD COMPARATIVE EFFICACY AND SAFETY OF CELL POLYMORPHISMS AND HEMOGLOBIN LEVELS IN Saturday, November 21 DIHYDROARTEMISININ PLUS AMODIAQUINE OR MALI SULFADOXINE -PYRIMETHAMINE IN THE TREATMENT 1 1 2 Seidina A. S. Diakité , Saibou Doumbia , Tatiana M. Lopera-Mesa , Karim OF ACUTE UNCOMPLICATED FALCIPARUM MALARIA IN Traoré1, Drissa Konaté1, Mory Doumbia1, Michael A. Krause2, Ababacar Diouf2, Maria Cecilia Huaman2, Jennifer M. Anderson2, Seydou Doumbia1, NIGERIAN CHILDREN Carole A. Long2, Mahamadou Diakité1, Rick M. Fairhurst2 George O. Ademowo1, Catherine O. Falade1, H. Dada-Adegbola2, 1Malaria Research and Training Center, Bamako, Mali, 2Laboratory of Malaria Oluwatoyin Ogunkunle3 and Vector Research, National Institute of Allergy and Infectious Diseases, National 1Institute for Advanced Medical Research and Training, College of Medicine, University Institutes of Health, Rockville, MD, United States of Ibadan, Ibadan, Nigeria, 2College of Medicine, Ibadan, Nigeria, 3Department of Paediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria

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851 856

AN OPEN RANDOMIZED CLINICAL TRIAL IMPACT OF THE IMPLEMENTATION OF IPTI ON EPI IN COMPARING TWO ARTESUNATE-BASED VACCINES COVERAGE IN THE DISTRICT OF KOLOKANI, COMBINATION TREATMENTS [ARTESUNATE/ MALI: A CLUSTER RANDOMIZED CONTROL TRIAL SULFAMETHOXYPYRAZINE/PYRIMETHAMINE Alassane Dicko1, Issaka Sagara1, Sidy Toure1, Mariam Traore1, Abdoulbaki (FIXED DOSE OVER 24 HOURS) AND ARTESUNATE/ I. Diallo1, Mohamed Dicko1, Amadou Barry1, Ousmane B. Toure1, Oumar M. AMODIAQUINE (FIXED DOSE OVER 48 HOURS)] ON Coulibaly2, Nadouma Keita3, Bakary Konate4, Alexandra de Sousa5, Ogobara 6 PLASMODIUM FALCIPARUM MALARIA IN NIGERIAN Doumbo 1Malaria Research and Training Center, Bamako, Mali, 2District Health Center of CHILDREN Kolokani, Kolokani, Mali, 3District Health Center, Bamako, Mali, 4Health Offi ce of Adejumoke I. Ayede1, Adegoke G. Falade1, Akintunde Sowumi2, Herwig Koulikoro, Koulikoro, Mali, 5UNICEF HQ, New York, NY, United States, 6Malaria Jansen3 Research and Training Center, University of Bamako, Bamako, Mali 1Department of Pediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria, 2Institute of Advanced Medical Research and Training, College of Medicine, University of 857 Ibadan, Ibadan, Nigeria, 3Dafra Pharma, Slachuistraat, Belgium DIRECT SYNTHESIS OF CYCLOGUANIL AND 852 MISLOCALIZATION OF MITOCHONDRIAL DIHYDROFOLATE REDUCTASE-THYMIDILATE A BAYESIAN APPROACH TO REDUCING SYNTHASE (DHFR-TS) IN ATOVAQUONE-PROGUANIL MISCLASSIFICATION IN ANTIMALARIAL EFFICACY TREATED P. FALCIPARUM STUDIES Joseph W. Fowble1, Ling Li2, Jeremy E. McLean1, Prakash Pendyala1, John Kimberly A. Porter, Christina Burch, Charles Poole, Jonathan Juliano, White1, Malcolm J. Gardner2, Pradipsinh K. Rathod1 Steven R. Meshnick 1University of Washington, Seattle, WA, United States, 2Seattle Biomedical Research University of North Carolina - Chapel Hill, Chapel Hill, NC, United States Institute, Seattle, WA, United States (ACMCIP Abstract) 853 858 SAFETY AND EFFICACY OF ARTEMETHER- LUMEFANTRINE (AL; COARTEM®) IN THE TREATMENT DOSE-DEPENDENT RISK OF NEUTROPENIA OF ACUTE, UNCOMPLICATED FALCIPARUM MALARIA FOLLOWING SEVEN-DAY COURSES OF ARTESUNATE IN ADULTS (>16 YEARS OLD): A POOLED ANALYSIS OF MONOTHERAPY IN ADULT CAMBODIAN PATIENTS INDIVIDUAL PATIENT DATA WITH ACUTE FALCIPARUM MALARIA Francois Nosten1, Srivicha Krudsood2, Philip Hunt3, Verena Walter4, Hans Delia Bethell1, Youry Se1, Chanthap Lon1, Duong Socheat2, David Saunders1, Peter Beck5, Anne-Claire Marrast4, Marc Cousin4, Philip J. Rosenthal6 Sea Darapiseth2, Jessica Lin1, Sabaithip Sriwichai1, Worachet Kuntawungin1, 1Shoklo Malaria Research Unit, Mae Sot Tak, Thailand, 2WHO CC for Clinical Sok Poeu2, Sue Lee3, Ses Sarim4, Stuart Tyner1, Bryan Smith1, Mark Fukuda1 Management of Malaria, Mahidol University, Bangkok, Thailand, 3Novartis Pharma, 1Armed Forces Research Institute of the Medical Sciences, Bangkok, Thailand, 2Center Horsham, United Kingdom, 4Novartis Pharma AG, Basel, Switzerland, 5Swiss Tropical for Parasitology, Entomology and Malaria Control, Pnom Penh, Cambodia, 3MORU, Institute, Basel, Switzerland, 6Department of Medicine, University of California, San Bangkok, Thailand, 4Tasanh Health Center, Samlot, Cambodia Francisco, CA, United States 859 854 THE EFFECTS OF CHRONIC ADMINISTRATION OF SAFETY AND EFFICACY OF ARTEMETHER- LOPINAVIR/RITONAVIR ON THE PHARMACOKINETICS LUMEFANTRINE (AL, COARTEM®) IN THE TREATMENT OF QUININE IN HEALTHY VOLUNTEERS OF ACUTE, UNCOMPLICATED FALCIPARUM MALARIA Myaing M. Nyunt, Edward Fuchs, Stehen W. Eisenger, Craig W. Hendrix IN CHILDREN (BELOW 16 YEARS OLD): A POOLED Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States ANALYSIS OF INDIVIDUAL PATIENT DATA Michael Makanga1, Hans Peter Beck2, Philip Hunt3, Verena Walter4, Anne- Claire Marrast4, Marc Cousin4, Philip J. Rosenthal5 1European and Developing Countries Clinical Trials Partnership, Cape Town, South Africa, 2Swiss Tropical Institute, Basel, Switzerland, 3Novartis Pharma, Horsham, United Kingdom, 4Novartis Pharma AG, Basel, Switzerland, 5Department of Medicine, University of California, San Francisco, CA, United States

855

THERAPEUTIC EFFICACY AND EFFECTS OF ARTESUNATE-MEFLOQUINE AND MEFLOQUINE ON GAMETOCYTE CARRIAGE IN CHILDREN WITH UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA IN SOUTHWEST NIGERIA Akintunde Sowunmi, Grace O. Gbotosho, Christian T. Happi, Titilope M. Okuboyejo, Oluchi Nkogho, Onikepe A. Folarin, Sulayman T. Balogun Department of Pharmacology and Therapeutics and Institute for Advanced Medical Research and Training, University of Ibadan, Ibadan, Nigeria

182 ASTMH 58th Annual Meeting www.astmh.org

MALARIA - DIAGNOSIS 864

HEALTH WORKERS’ USE OF MALARIA RAPID 860 DIAGNOSTIC TESTS (RDTS) TO GUIDE CLINICAL DECISION-MAKING IN RURAL DISPENSARIES, GLOBAL SEQUENCE VARIATION IN THE HISTIDINE- TANZANIA RICH PROTEIN 2 OF PLASMODIUM FALCIPARUM: 1 2 1 IMPLICATIONS FOR PERFORMANCE OF RAPID M. Irene Masanja , Meredith McMorrow , Elizeus Kahigwa , Salim M. Abdulla1, S. Patrick Kachur2 DIAGNOSTIC TESTS FOR MALARIA 1Ifakara Health Institute, Dar es Salaam, United Republic of Tanzania, 2Centers for Joanne T. Baker1, Michelle Gatton2, Mei-Fong Ho2, Anita Pelecanos2, David Disease Control and Prevention, Atlanta, GA, United States Bell3, John Barnwell4, Jeffery Hii5, Bernhards Ogutu6, Wellington Oyibo7, ShanQing Wang8, Jennifer Luchavez9, Christopher Membi10, Lyda Osario11, 865 Myat Phone Kyaw12, Petra Clowes13, Inge Kroidl13, Dionicia Gamboa14, 15 16 17 18 Frederic Ariey , Djibrine Djalle , Didier Menard , Marinete Marins Povoa , COMPARISON OF REAL-TIME PCR AND MICROSCOPY Malti Adhin19, Nanhua Chen1, James McCarthy2, Qin Cheng1 1Australian Army Malaria Institute, Enoggera, Australia, 2Queensland Institute of FOR DIAGNOSIS OF MALARIA IN MALAWIAN Medical Research, Herston, Australia, 3Western Pacifi c Regional Offi ce of the World PREGNANT WOMEN Health Organization, Manila, Philippines, 4Centers for Disease Control and Prevention, Anne-Maria Rantala1, Steve M. Taylor2, Paul A. Trottman2, Mari Luntamo1, Atlanta, GA, United States, 5Western Pacifi c Regional Offi ce of the World Health Bernard Mbewe3, Kenneth Maleta3, Teija Kulmala1, Per Ashorn1, Steven R. Organization, Solomon Islands, Solomon Islands, 6Centre for Clinical Research, Meshnick2 Kenya Medical Research Institute, Kisumu, Kenya, 7College of Medicine, University of 1Department of International Health, University of Tampere, Tampere, Finland, Lagos, Odoaraba, Lagos, Nigeria, 8Hainan Provincial Centre for Disease Control and 2Gillings School of Global Public Health, University of North Carolina, Chapel Hill, Prevention, Haikou, Hainan, China, 9Research Institute for Tropical Medicine, Alabang, NC, United States, 3Division of Community Health, University of Malawi College of Philippines, 10Bagamoyo/Ifakara Health Research and Development Centre, Ifakara, Medicine, Blantyre, Malawi United Republic of Tanzania, 11Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia, 12Lower Myanmar Department of Medical Research, Yangon, 866 Myanmar, 13Mbeya Medical Research Programme, Mbeya, United Republic of Tanzania, 14Instituto de Medicina Tropical Alexander Von Humboldt, Peru, Peru, 15Pasteur Institute of Cambodia, Phnom Penh, Cambodia, 16Institut Pasteur de Bangui, Bangui, USE OF ICT MAL PF RAPID DIAGNOSTIC TEST Congo, The Democratic Republic of the, 17Institut Pasteur de Madagascar, Madagascar, CASSETTES FOR POLYMERASE CHAIN REACTION (PCR) Madagascar, 18Evandro Chagas Institute, Belem, Brazil, 19Anton de Kom Universiteit ANALYSIS OF PLASMODIUM FALCIPARUM RNA ANALYSIS van Suriname, Paramibo, Suriname IN ZAMBIA

1 2 2 2 861 Hawela B. Moonga , Berlin Londono , Thomas Eisele , Joe Keating , John M. Miller3, Elizabeth Chizema-Kawesha1, Donald Krogstad2 1National Malaria Control Centre, Lusaka, Zambia, 2Tulane University School of MALARIA DIAGNOSIS BY POLYMERASE CHAIN Public Health and Tropical Medicine, New Orleans, LA, United States, 3PATH Malaria REACTION BASED ASSAY USING A POOLING STRATEGY Control and Evaluation Partnership in Africa (MACEPA), Lusaka, Zambia Ajay Bharti, Scott L. Letendre, Kailash P. Patra, Joseph M. Vinetz, Davey (ACMCIP Abstract) M. Smith University of California San Diego, La Jolla, CA, United States 867 (ACMCIP Abstract) MOLECULAR TEST FOR VIVAX MALARIA WITH LOOP- MEDIATED ISOTHERMAL AMPLIFICATION METHOD IN 862 CENTRAL CHINA Feng Lu1, Qi Gao2, Junhu Chen1, Yue Wang1, Huayun Zhou2, Jun Cao2, A COMPARISON OF THE SENSITIVITIES OF DETECTION Weimin Wang2, Eun-Taek Han1 OF PLASMODIUM FALCIPARUM GAMETOCYTES BY 1Kangwon National University College of Medicine, Chuncheon, Gangwon-do, Republic of MAGNETIC FRACTIONATION, THICK BLOOD FILM, AND Korea, 2Jiangsu Institute of Parasitic Diseases, Wuxi, China RT-PCR TECHNIQUES Stephan Karl, Tim G. St. Pierre, Timothy M. Davis 868 The University of Western Australia, Perth, Australia DETECTION OF P. FALCIPARUM IN SALIVA USING 863 RAPID DIAGNOSTIC TEST AND POLYMARASE CHAIN REACTION (PCR) IN PATIENTS WITH ACUTE MALARIA-RELATED MORTALITY IN HOSPITALIZED UNCOMPLICATED MALARIA IN SOUTHWEST NIGERIA

UGANDAN CHILDREN IN AN AREA OF HIGH MALARIA Grace O. Gbotosho, Christian T. Happi, Onikepe Folarin, Keyamo A. Saturday, November 21 TRANSMISSION Ochuko, A. Sijuade, A. Sowunmi, A. Oduola 1Malaria Research Laboratories, College of Medicine University of Ibadan, Ibadan, Robert O. Opoka1, Paul Teekam2, Paul Bangirana1, Charles Engoru3, Justus Nigeria Byarugaba1, Chandy C. John2 1Makerere University, Kampala, Uganda, 2Global Pediatrics Program, Department of (ACMCIP Abstract) Pediatrics, Minneapolis, MN, United States, 3Soroti Regional Referral Hospital, Soroti, Uganda

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869 875

HIGH-THROUGHPUT QUANTITATIVE MULTIPLEX RANDOMIZED CLINICAL TRIAL (RCT) WITH A REVERSE TRANSCRIPTASE 5’ NUCLEASE PCR ASSAY CROSSOVER STUDY DESIGN TO EXAMINE THE SAFETY FOR QUANTITATION OF PLASMODIUM FALCIPARUM AND PHARMACOKINETICS OF A 2100 MG DOSE OF AQ- GAMETOCYTEMIA 13 AND THE EFFECTS OF A STANDARD FATTY MEAL ON Emily G. Clemens1, Megan E. Reller1, Karen C. Carroll1, Tamaki Kobayashi2, ITS BIOAVAILABILITY William J. Moss2, J. Stephen Dumler1 Fawaz Mzayek1, Haiyan Deng2, M. Azam Hadi2, Vidya Mave2, Frances J. 1The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2The Mather2, Christopher Goodenough2, David M. Mushatt2, Juan J. Lertora3, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United Donald Krogstad2 States 1University of Memphis, Memphis, TN, United States, 2Tulane University Health Sciences Center, New Orleans, LA, United States, 3Clinical Center, National Institutes of 870 Health, Bethesda, MD, United States

FIELD PERFORMANCE OF THE RAPID DIAGNOSTIC 876 TESTS PARACHECK AND FALCIVAX IN TSUNAMI- AFFECTED DISTRICTS OF ACEH AND NIAS, INDONESIA INITIATING PRECLINICAL EVALUATIONS OF REVERSED Sigrid Hahn1, David Muriuki2, Braden Hexom1, Richard Allan2 CHLOROQUINES 1Mount Sinai School of Medicine, New York, NY, United States, 2The MENTOR Steven J. Burgess1, Bornface Gunsaru2, Jane X. Kelly1, Shawheen Shomloo1, Initiative, Skipton, United Kingdom Westin Morrill1, Martin J. Smilkstein3, David H. Peyton2 1DesignMedix, Portland, OR, United States, 2Portland State University, Portland, 871 OR, United States, 3Oregon Translational Research and Drug Development Institute, Portland, OR, United States REFERENCE LABORATORY VERIFICATION, 877 VALIDATION, AND QUALITY ASSURANCE OF REAL- TIME PCR AND ICT FOR THE DIAGNOSIS OF MALARIA Krishna Khairnar, Rachel Lau, Donald S. Martin, Dylan R. Pillai LOW DOSE CYSTEAMINE POTENTIATES THE ANTI- OAHPP – University of Toronto, Toronto, ON, Canada MALARIAL ACTIVITY OF ARTEMISININ DERIVATIVES IN VIVO 872 Gundula Min-Oo1, Kodjo Ayi2, Silayuv E. Bongfen1, Anny Fortin3, Mifong Tam1, Mary M. Stevenson1, Kevin C. Kain2, Philippe Gros1 USE OF THE INTEGRATED MANAGEMENT OF 1McGill University, Montreal, QC, Canada, 2University of Toronto, Toronto, ON, 3 CHILDHOOD ILLNESS CRITERIA AND SYNDROMIC Canada, Dafra Pharma, Turnhout, Belgium DIAGNOSIS OF MALARIA IN RURAL SIERRA LEONE 878 Obinna N. Nnedu University of Washington, Seattle, WA, United States TETRACYCLIC BENZOTHIAZEPINES: A NOVEL CLASS OF PLASMODIUM FALCIPARUM CYTOCHROME BC1 MALARIA – DRUG DEVELOPMENT INHIBITORS Carolyn Dong1, Sameer Urgaonkar2, Joe Cortese2, Javier Francisco3, Jose F. 873 Garcia-Bustos3, Frederico M. Gomez-de-las-Heras3, Vishal Patel4, Leila Ross5, Jeffrey D. Dvorin6, Manoj T. Duraisingh1, Dyann Wirth1, Ralph Mazitschek7, 5 NEXT GENERATION QUINOLINE METHANOLS FOR Jon Clardy 1Harvard School of Public Health, Department of Immunology and Infectious Disease, MALARIA CHEMOPROPHYLAXIS AND IPTX Boston, MA, United States, 2Broad Institute Infectious Diseases Initiative, Boston, Erin E. Milner1, Sean R. Gardner1, Jayendra B. Bhonsle1, Diana P. Caridha1, MA, United States, 3Drug Discovery Biology Group, Diseases of the Developing World Dustin Carroll1, Lucia Gerena1, Montip Gettayacamin2, Charlotte A. Lanteri1, Center, GlaxoSmithKline R&D, Tres Cantos, Madrid, Spain, 4Harvard School of Public Qiqui Li1, ThuLan Luong1, William F. McCalmont1, Victor Melendez1, Jay Health, Department of Immunology and Infectious Disease and Harvard Medical School, K. Moon1, Norma E. Roncal1, Jason C. Sousa1, Anchalee Tangteung2, Qiang Department of Biological Chemistry and Molecular Pharmacology, Boston, MA, United Zeng1, Jing Zhang1, Peter Wipf3, Lisa Xie1, Geoffrey S. Dow1 States, 5Harvard Medical School, Department of Biological Chemistry and Molecular 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2Armed Pharmacology, Boston, MA, United States, 6Harvard School of Public Health and Forces Research Institute of Medical Sciences, Bangkok, Thailand, 3University of Children’s Hospital Boston, Division of Infectious Diseases, Boston, MA, United States, Pittsburgh, Pittsburgh, PA, United States 7Broad Institute Infectious Diseases Initiative and Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology and Massachusetts General 874 Hospital, Center for Systems Biology, Boston, MA, United States

IDENTIFICATION AND DEVELOPMENT OF A NOVEL 879 CHEMICAL SERIES WITH ACTIVITY AGAINST BOTH BLOOD- AND LIVER-STAGES OF PLASMODIUM PLASMODIUM FALCIPARUM GAMETOCYTOCIDAL FALCIPARUM ACTIVITY OF PROTEASOME INHIBITOR EPOXOMICIN Beata Czesny, Samrawit Goshu, Kim C. Williamson Clare E. Gutteridge1, Brett W. Sadowski1, Michael C. Baxter1, Michael T. Loyola University Chicago, Chicago, IL, United States O’Neil2, William F. McCalmont2, Lucia Gerena2 1United States Naval Academy, Annapolis, MD, United States, 2Walter Reed Army (ACMCIP Abstract) Institute of Research, Silver Spring, MD, United States

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880 886

METABOLIC PROFILING OF PRIMAQUINE USING IN COLOMBIAN NETWORK FOR SURVEILLANCE OF VITRO AND IN VIVO APPROACHES PLASMODIUM FALCIPARUM IN VITRO SUSCEPTIBILITY Xiannu Jin, Dustin Carroll, Thu-Lan Luong, Gavin Black, Tanya Jenkins, TO ANTIMALARIAL DRUGS: PARASITE’S PHENOTYPE Raul Olmeda, Necole Reese, Qigui Li, Lisa Xie, Jing Zhang, Michael T. AFTER THE ARTEMISININ-BASED COMBINATION O’Neil, Michael P. Kozar, Ai J. Lin, Colin Ohrt, Jason C. Sousa, Victor THERAPIES (ACT) IMPLEMENTATION Melendez Gustavo Diaz1, Zuleima Pava1, Javier Martínez2, Lidia Montenegro2, Diego Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver 1 3 1 Spring, MD, United States Echeverry , Pedro Gil , Claribel Murillo 1Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia, 2Universidad del Valle, Facultad de Salud. Escuela de Bacteriología y 881 Laboratorio Clínico, Cali, Colombia, 3Karolinska Institute, Stockholm, Sweden

IN VITRO AND IN VIVO METABOLISM AND DISPOSITION 887 STUDIES OF IMIDAZOLIDINEDIONE ANALOGS Jason C. Sousa, Raul Olmeda, Dustin Carroll, Gavin Black, Xiannu Jin, A RAPID PYROSEQUENCING METHOD FOR DETECTION Necole Reese, Tanya Jenkins, Xihong Wang, Ramadas Sathunuru, Liang OF SINGLE NUCLEOTIDE POLYMORPHISM (SNPS) Zhang, Ai J. Lin, Qigui Li, Lisa Xie, Jing Zhang, Michael P. Kozar, Victor ASSOCIATED WITH ANTIMALARIAL RESISTANCE Melendez Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Krishna Khairnar, Dylan R. Pillai Spring, MD, United States University of Toronto and Ontario Public Health Laboratories, Toronto, ON, Canada

882 888

IN VITRO AND IN VIVO METABOLIC PROFILE OF TWO SCREENING AND GENETIC MAPPING TARGETS OF DEOXO-IMIDAZOLIDINEDIONE ANALOGS DIFFERENTIAL CHEMICAL-RESPONSE PHENOTYPES IN Thu-Lan Luong, Xianjun Liu, Ai J. Lin, Qigui Li, Lisa Xie, Jing Zhang, Raul PLASMODIUM FALCIPARUM Olmeda, Michael P. Kozar, Jason C. Sousa, Victor Melendez Jing Yuan1, Ronald Johnson2, Ruiling Huang2, Jennifer Wichterman2, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Hongying Jiang1, Karen Hayton1, David Fidock3, Thomas Wellems1, James Spring, MD, United States Inglese2, Christopher Austin2, Xinzhuan Su1 1Laboratory of Malaria and Vector Research/National Institute of Allergy and Infectious 883 Diseases/National Institutes of Health, Rockville, MD, United States, 2NCGC/NHGRI/ National Institutes of Health, Rockville, MD, United States, 3Columbia University, New York, NY, United States IN VITRO METABOLISM AND DISPOSITION (ACMCIP Abstract) EVALUATIONS OF QUINOLINE METHANOL ANALOGS OF MEFLOQUINE MODIFIED AT THE 4-POSITION 889 Dustin Carroll, Geoffrey S. Dow, Erin Milner, William F. McCalmont, Charlotte A. Lanteri, Norma E. Roncal, Lucia Gerena, Xiannu Jin, Raul ACCUMULATION OF CHLOROQUINE (CQ) AND AN Olmeda, Necole Reese, Lalaine Anova, Constance Asher, Jason C. Sousa, INVESTIGATIONAL AMINOQUINOLINE (AQ-13) BY Victor Melendez Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver CQ-SUSCEPTIBLE AND CQ-RESISTANT PLASMODIUM Spring, MD, United States FALCIPARUM Haiyan Deng, Simon J. Hocart, Donald J. Krogstad 884 Tulane University Health Sciences Center, New Orleans, LA, United States (ACMCIP Abstract) DEVELOPMENT OF A NETWORK OF INVESTIGATORS TO STUDY ANTIMALARIAL PROPHYLAXIS IN THE ASIA- 890 PACIFIC REGION THE GENETIC BACKGROUND OF PLASMODIUM David Saunders1, Gregory Deye2, Kent Bennett2, Colin Ohrt2 1Armed Forces Research Institute of the Medical Sciences, Bangkok, Thailand, 2Walter FALCIPARUM DETERMINES THE EXTENT TO Reed Army Institute of Research, Silver Spring, MD, United States WHICH MUTANT PFCRT CONFERS RESISTANCE TO CHLOROQUINE MALARIA – DRUG RESISTANCE Stephanie G. Valderramos1, Juan-Carlos Valderramos2, Adele M. Lehane3, Lise Musset2, Lisa A. Purcell2, Odile Mercereau-Puijalon4, Eric Legrand5, Kiaran Kirk3, David A. Fidock2 Saturday, November 21 885 1Albert Einstein College of Medicine, Bronx, NY, United States, 2Columbia University, New York, NY, United States, 3The Australian National University, Canberra, 4 5 RAPID INCREASES IN THE PREVALENCE OF PFDHFR Australia, Institut Pasteur, Paris, France, Institut Pasteur de la Guyane, Cayenne, French Guiana AND PFDHPS MUTANT HAPLOTYPES DURING THE PERIOD OF SP USE AS THE FIRST-LINE ANTIMALARIAL IN KISUMU, KENYA Maroya D. Spalding1, Fredrick Eyase2, Hoseah Akala2, Sheryl Bedno2, Rodney L. Coldren2, Norman C. Waters3, William J. Moss1 1Johns Hopkins School of Public Health, Baltimore, MD, United States, 2United States Army Research Unit-Kenya, Nairobi, Kenya, 3Walter Reed Army Institute of Research, Silver Spring, MD, United States

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891 MALARIA - EPIDEMIOLOGY

BALANCING FITNESS COSTS WITH CHLOROQUINE RESISTANCE: A “RAISON D’ÊTRE” FOR NOVEL PFCRT 897 ALLELES IN SOUTHEAST ASIA? A NEW MALARIA EXPERIMENTAL CHALLENGE SYSTEM; 1 1 2 3 Ines Petersen , Eugene Palatulan , Thierry Fandeur , Qin Cheng , Juan- INFECTION OF VOLUNTEERS BY THE BITE OF ASEPTIC Carlos Valderramos1, David A. Fidock1 1Columbia University, New York, NY, United States, 2Institut Pasteur, Paris, France, ANOPHELES STEPHENSI MOSQUITOES INFECTED WITH 3Australian Army Malaria Institute, Enoggera, Australia PLASMODIUM FALCIPARUM (NF54) SPOROZOITES Kirsten E. Lyke1, Matthew Laurens1, Matthew Adams1, Peter Billingsley2, 892 Adam Richman2, Mark Loyevsky2, Sumana Chakravarty2, Christopher V. Plowe3, Kim Lee Sim2, Robert Edelman1, Stephen Hoffman2 MOLECULAR CHARACTERIZATION OF RESISTANCE TO 1University of Maryland, Baltimore, MD, United States, 2Sanaria, Inc., Rockville, MD, 3 ARTEMISININ DRUGS IN PLASMODIUM FALCIPARUM United States, Howard Hughes Medical Institute, Baltimore, MD, United States Matthew S. Tucker1, Lucia Gerena2, Katherine Sorber3, Michelle Dimon3, 898 Azliyati Azizan1, Zhinning Wang2, Qin Cheng4, Dennis E. Kyle1 1University of South Florida, Tampa, FL, United States, 2Walter Reed Army Institute of Research, Rockville, MD, United States, 3University of California-San Francisco, San ESTIMATING THE RATE OF ACQUIRING IMMUNITY TO Francisco, CA, United States, 4Australian Army Malaria Institute, Enoggera, Australia SEVERE DISEASE DUE TO PLASMODIUM FALCIPARUM (ACMCIP Abstract) WITH AGE AND EXPOSURE Deirdre Hollingsworth1, Neil Ferguson1, Jamie Griffi n1, Christl Donnelly1, 893 Chris Drakeley2, Eleanor Riley2, Hugh Reyburn2, Azra Ghani1 1Imperial College London, London, United Kingdom, 2London School of Hygiene and ANTI-MALARIAL TREATMENT REGIMES FROM AN Tropical Medicine, London, United Kingdom EVOLUTIONARY PERSPECTIVE Silvie Huijben, Derek Sim, Brian Chan, Danielle Tomasello, Andrew Read 899 The Pennsylvania State University, University Park, PA, United States ASYMPTOMATIC CARRIAGE OF P. FALCIPARUM 894 PARASITES PROTECT AGAINST MALARIA ATTACKS DURING THE MALARIA HIGH TRANSMISSION SEASON VALIDATION OF PLATE COATING AND STORAGE IN CHILDREN UNDER FIVE YEARS LIVING IN A RURAL TECHNIQUES FOR IN VITRO DRUG SENSITIVITY AREA OF BURKINA FASO TESTING OF PIPERAQUINE, PYRONARIDINE, AND Tiono B. Alfred, Ouedraogo Alphonse, Diarra Amidou, Sanon Souleymane, LUMIFANTRINE Yaro Jean Baptist, Ouedraogo Espérance, Ouedarogo Amathe, Soulama Maneerat Rasameesoraj1, Kuntida Tangthongchaiwiriya1, David Saunders1, Issiaka, Bougouma Edith, Konaté T. Amadou, Nébié Issa, Sirima B. Sodiomon Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Mark Fukuda1, Harald Noedl2, Pascal Ringwald3, Paktiya Teja-Isavadharm1 1Armed Forces Research Institute of the Medical Sciences, Bangkok, Thailand, Faso 2Medical University of Vienna, Vienna, Austria, 3World Health Organization, Geneva, Switzerland 900

895 BURDEN OF MALARIA IN PREGNANCY IN AREAS OF STABLE AND UNSTABLE MALARIA TRANSMISSION IN COMPARISON OF GENOTYPING USING CAPILLARY VS. CHHATTISGARH, INDIA GEL ELECTROPHORESIS FOR TWO ANTIMALARIAL Neeru Singh1, Mrigendra P. Singh2, Manmohan M. Shukla2, Mohassir DRUG EFFICACY TRIALS IN UGANDA Hussain2, Aditya P. Dash3, Blair J. Wylie4, Kojo Yeboah-Antwi5, Lora Sabin5, Venkatachalam Udhayakumar6, Meghna Desai6, Davidson H. Hamer5 Vinay Gupta, Grant Dorsey, Philip Rosenthal, Bryan Greenhouse 1 2 University of California, San Francisco, San Francisco, CA, United States Regional Medical Research Centre (ICMR), Jabalpur, India, National Institute for Malaria Research Field Station, Jabalpur, India, 3National Institute for Malaria Research, Delhi, India, 4Department of Obstetrics, Massachusetts General Hospital, 896 Boston, MA, United States, 5Center for International Health and Development, Boston, MA, United States, 6Malaria Branch, Centers for Disease Control and Prevention, IN VITRO DRUG SENSITIVITY-PHARMACODYNAMIC Atlanta, GA, United States CORRELATES IN A CLINICAL TRIAL OF VARYING DOSES OF ARTESUNATE IN CAMBODIAN ADULT PATIENTS 901 WITH UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA DISTRIBUTION OF HAPLOTYPES CARRIED BY PFCRT, Stuart Tyner1, Wiriya Rutvisuttinunt1, Kritsanai Yingyuen1, Panjaporn PFDHFR AND PFDHPS IN TWO NEIGHBOURING Chaichana1, Siratchana Sundrakes1, Piyaporn Saingam1, Youry Se1, Delia GEOGRAPHICAL SITES FROM SOUTHERN COTE Bethell1, Sabaithip Sriwichai1, Chanthap Lon1, Phisit Khemawoot1, David D’IVOIRE 1 2 2 1 3 Saunders , Sea Darapiseth , Sok Poeu , Jessica Lin , Kurt Schaecher , Paktiya 1 1 1 2 1 1 2 1 Louis K. Penali , Berenger A. Ako , Offi anan A. Toure , Marnie Briceno , Tejaisavadharm , Bryan Smith , Duong Socheat , Mark M. Fukuda Carol H. Sibley2 1Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand, 2National 1Institut Pasteur de Cote d’Ivoire, Abidjan, Cote d’Ivoire, 2Genome Sciences Department, Center for Parasitology, Entomology and Malaria Control, Pnom Penh, Cambodia, 39th Seattle, WA, United States Area Medical Laboratory, Aberdeen Proving Ground, Maryland (ACMCIP Abstract)

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902 907

GENETIC DIVERSITY IN THE P. FALCIPARUM AND P. SEVERE MALARIA IN BATTAMBANG REFERRAL VIVAX MALARIA CELTOS GENE FROM SOUTHEAST HOSPITAL, CAMBODIA FROM 2006 TO 2008 ASIA, AFRICA AND SOUTH AMERICA REVEALS A David Saunders1, Chanthap Lon2, Nillawan Buathong1, Ngo Sithy3, Youry HIGHLY CONSERVED GENE WITH FOCAL REGIONS Se2, Ans Timmermans1, Jessica Lin1, Mark Fukuda1, Duong Socheat4, Delia OF NON-SYNONOMOUS MUTATIONS UNDER IMMUNE Bethel1 1 2 SELECTIVE PRESSURE CONFIRMED BY GENE Armed Forces Research Institute of the Medical Sciences, Bangkok, Thailand, Armed Forces Research Institute of the Medical Sciences, Phnom Penh, Cambodia, 3Battambang SEQUENCING, 3D STRUCTURE PREDICTION AND Referral Hospital, Battambang, Cambodia, 4CNM, Phnom Penh, Cambodia PEPTIDE MAPPING Eric B. Ockenhouse1, Elke Bergmann-Leitner2, Matthew Riley2, Jonathan 908 D’Ambrozio3, M. Lee4, X. Hu4, Anders Wallqvist4, Paul Graf5, John Waitumbi6, Evelina Angov2, Christian F. Ockenhouse2 VALIDATING SEVERE ANEMIA AS A PROXY FOR 1Bethesda-Chevy Chase High School-Walter Reed Army Institute of Research, Silver MALARIA: EVIDENCE FROM A NATIONAL SURVEY Spring, MD, United States, 2USMMVP-Walter Reed Army Institute of Research, Silver Spring, MD, United States, 3Walter Reed Army Institute of Research, Silver Spring, Jasbir K. Sangha, Kiersten B. Johnson MD, United States, 4TATRC, MRMC, Frederick, MD, United States, 5Naval Medical ICF Macro, Calverton, MD, United States Research Center Detachment-Peru, Lima, Peru, 6USAMRU-Kenya, Kisumu, Kenya MALARIA - IMMUNOLOGY 903

ASSESSMENT OF MALARIA MORTALITY IN 910 AFRICAN CHILDREN LIVING IN A MALARIA STABLE TRANSMISSION AREA IN BURKINA FASO: A PART OF LIMITED GLOBAL DIVERSITY OF ANTIBODY EPITOPES MALARIA VACCINE TRIALS SITE CHARACTERISATION EXPRESSED BY PLACENTAL BINDING PLASMODIUM STUDY FALCIPARUM VARIANTS Konate A. None, Lankoande Malik, Ouedraogo Alphonse, Yaro Jean Mirja Hommel1, Salenna R. Elliott1, Greg Kelly2, Freya J. Fowkes1, Michael Baptiste, Ouedraogo Esperance, Tiono Alfred, Sirima Sodiomon Bienvenu F. Duffy2, Joanne Chesson1, Danielle I. Stanisic1, Ivo Mueller3, Marion Avril4, CNRFP, Ouagadougou, Burkina Faso Viju Soma4, Joseph D. Smith4, Stephen J. Rogerson2, James G. Beeson1 1The Walter and Eliza Hall Institute, Parkville, Victoria, Australia, 2Department of 904 Medicine, University of Melbourne, Parkville, Victoria, Australia, 3Papua New Guinea Institute of Medical Research, Magang, Papua New Guinea, 4Seattle Biomedical Research Institute, Seattle, WA, United States THE DYNAMICS OF MIXED AND ALTERNATING SPECIES (ACMCIP Abstract) INFECTIONS OF PLASMODIUM VIVAX AND P. FALCIPARUM IN LOW TRANSMISSION AREAS. 911 Rosalynn L. Ord1, Jean Hernandez2, Connie Leeper3, Praveen Bharti4, Neeru Sing4, OraLee Branch1 ANTIBODIES AGAINST THE ERYTHROCYTE BINDING 1New York University, New York, NY, United States, 2Universidad Nacional de ANTIGENS OF PLASMODIUM FALCIPARUM ARE STRONGLY 3 la Amazonia Peruana, Iquitos, Peru, University of Alabama at Birmingham, ASSOCIATED WITH PROTECTION AGAINST CLINICAL Birmingham, AL, United States, 4Regional Medical Research Centre for Tribals, Jabalpur, India MALARIA AND HIGH PARASITEMIA Jack S. Richards1, Danielle I. Stanisic2, Pascal Michon2, Elijah Dabod2, 905 Chetan E. Chitnis3, David E. Narum4, Jennifer K. Thompson1, Alan F. Cowman1, Ivo Mueller2, James G. Beeson1 1 2 THE LONGITUDINAL PROROGATION OF COMPLEX P. Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea, 3International FALCIPARUM INFECTIONS CULTIVATES GENETICALLY Centre for Genetic Engineering and Biotechnology, New Delhi, India, 4National Institutes DISTINCT CLONAL POPULATIONS of Health, Rockville, MD, United States Patrick L. Sutton1, Lindsay Prado Torres2, Claudia Silva2, OraLee Branch1 1New York University, New York, NY, United States, 2Universidad Nacional de la 912 Amazonia Peruana, Iquitos, Peru ACQUISITION OF ANTIBODIES TO MEROZOITE 906 SURFACE PROTEIN 3 AMONG RESIDENTS OF KOROGWE, NORTHEASTERN TANZANIA GENETIC DIVERSITY OF PLASMODIUM FALCIPARUM Saturday, November 21 Method D. Segeja, B.P. Mmbando, S.D. Misago, J.P. Lusingu and Martha FROM WESTERN KENYA HIGHLAND AREAS PRONE M. Lemnge MALARIA EPIDEMICS National Institute for Medical Research, Tanga Centre, Tanga, United Republic of David M. Menge1, Kacey C. Ernst2, John M. Vulule3, Chandy John1 Tanzania 1University of Minnesota, Minneapolis, MN, United States, 2University of Arizona, (ACMCIP Abstract) Tucson, AZ, United States, 3Kenya Medical Research Institute, Kisumu, Kenya

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913 918

BIOMARKERS OF IMMUNO-HEMATOLOGICAL MSP-119 HAPLOTYPE SPECIFICITY OF FUNCTIONAL

RELEVANCE ASSOCIATED WITH SEVERE MALARIA ANTI-MSP-119 ANTIBODIES IN PEDIATRIC ACUTE ANAEMIA IN GHANAIAN CHILDREN MALARIA INFECTION Richard H. Asmah1, Selorme Adupko2, Micheal Ofori2, Alexander Nyarko2, Arlene E. Dent1, Rhonda Kimmel1, Christopher Yohn1, Peter Sumba2, John Eugene Baah1, Ben Gyan2, Edwin Wiredu1, John Tetteh2, Patrick Ayeh- Vulule2, Ann Moormann1 Kumi1, Charles Brown1 1Case University, Cleveland, OH, United States, 2KEMRI, Kisumu, Kenya 1School of Allied Health Sciences, University of Ghana, Accra, Ghana, 2Noguchi (ACMCIP Abstract) Memorial Institute for Medical Research, University of Ghana, Accra, Ghana, (ACMCIP Abstract) 919

914 ENGINEERING APICAL MEMBRANE ANTIGEN-1 TO OVERCOME ANTIGENIC DIVERSITY IN THIS MALARIA ANTIBODY RESPONSES TO EBA-175 REGION II IN VACCINE CANDIDATE ADULTS AND CHILDREN IN A MALARIA ENDEMIC AREA Michael Foley1, Karen Harris1, Madhavi Khore1, Coley Andrew1, Robin F. OF GHANA Anders1, Sheetij Dutta2 Rafi q Okine, Dorothy Anum, Helena Lamptey, John Tetteh, Beverly Egyir, 1La Trobe University, Melbourne, Australia, 2Walter Reed Army Institute of Research, Ben Gyan, Kwadwo Koram, Daniel Dodoo Silver Spring, MD, United States Noguchi Memorial Institute for Medical Research, Accra, Ghana (ACMCIP Abstract) 920

915 EXAMINATION OF HUMORAL AND CELLULAR MEMORY RESPONSES TO PLASMODIUM FALCIPARUM IN THE RELATIONSHIP BETWEEN CLINICAL MALARIA AND PERUVIAN AMAZON IGG RESPONSES TO A PANEL OF MALARIA SPECIFIC Eva Clark1, Claudia Silva2, Carlos Padilla3, Oralee Branch4 VACCINE CANDIDATES IN CHILDREN LIVING IN 1University of Alabama at Birmingham, Birmingham, AL, United States, 2Universidad SEASONAL MALARIA TRANSMISSION AREA OF Nacional Amazonia Peruana, LIPNAA, Iquitos, Peru, 3Instituto Nacional de Salud, BURKINA FASO Lima, Peru, 4New York University, Department of Medical Parasitology, New York, NY, Diarra Amidou1, Ouedraogo Andre Lin1, Tiono Alfred1, Soulama Issiaka1, United States Ouedraogo Alphonse1, CHARRIF Mariama K.1, Yaro Jean Baptist1, (ACMCIP Abstract) Ouedraogo Espérance1, Bougouma Edith C.1, Sanon Souleymane1, Konate Amadou T.1, Gansane Adama1, Corradin Gampietro2, Dodoo Daniel3, Sirima MALARIA – MOLECULAR BIOLOGY B. Sodiomon1, Nébié Issa1 1CNRFP, Ouagadougou, Burkina Faso, 2University of Lausane, Lausane, Switzerland, 3Noguchi Memorial Institute, Accra, Ghana 921 (ACMCIP Abstract) MASSIVELY PARALLEL PYROSEQUENCING TO DEFINE 916 IN HOST DIVERSITY OF PLASMODIUM FALCIPARUM: BLANTYRE, MALAWI CYTOKINE BIOMARKERS OF ASYMPTOMATIC MALARIA Jonathan J. Juliano1, Victor Mwapasa2, Steven R. Meshnick1 1 1 1 2 Nana O. Wilson , Tammiki Bythwood , Wesley Solomon , Pauline Jolly , 1University of North Carolina, Chapel Hill, NC, United States, 2University of Malawi, 2 2 1 Nelly Yatich , Faisal Shuaib , Jonathan K. Stiles Blantyre, Malawi 1Morehouse School of Medicine, Atlanta, GA, United States, 2University of Alabama at Birmingham, Birmingham, AL, United States 922 (ACMCIP Abstract)

917 COMPARISON OF THREE DNA EXTRACTION METHODS FROM BLOOD SAMPLES COLLECTED IN MALARIA GENE CONTENT POLYMORPHISMS OF KILLER CELL RAPID DIAGNOSTIC TESTS (MRDTS) IMMUNOGLOBULIN-LIKE RECEPTORS (KIRS) IN Luis Sanchez, Erik Mercado, Juan Contreras, Dionicia Gamboa THE SUSCEPTIBILITY TO AND PROTECTION FROM Instituto de Medicina Tropical “Alexander Von Humboldt”, Universidad Peruana Cayetano Heredia, Lima, Peru PLACENTAL MALARIA IN HIV-1 NEGATIVE AND (ACMCIP Abstract) HIV-1 POSITIVE PREGNANT WOMEN IN WESTERN KENYA 923 Yusuf O. Omosun1, John Williamson1, Caroline Othoro2, Mary Carrington3, Maureen P. Martin3, John Ayisi2, Anne Maria van Eijk2, Juliana Otieno4, ASYMPTOMATIC MALARIA DETECTION BY PCR AMONG 1 1 1 5 Renu B. Lal , Richard Steketee , Bernard Nahlen , Feiko ter Kuile , Laurence A COLLATERAL NATIVE POPULATION IN AN ENDEMIC Slutsker1, Ya Ping Shi1 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Center for REGION AT THE PERUVIAN-ECUADORIAN BORDER Vector Biology and Control Research, Kenyan Medical Research Institute, Kisumu, Elizabeth Villasis1, Jorge Cacho1, Jorge Bendezu1, Victor Neyra1, Jaime M. Kenya, 3Cancer and Infl ammation Program, Laboratory of Experimental Immunology, Bernal2, Dionicia Gamboa1 SAIC-Frederick, Frederick, MD, United States, 4New Nyanza Provincial General 1Instituto de Medicina Tropical “Alexander Von Humboldt”, Universidad Peruana Hospital, Ministry of Health, Kisumu, Kenya, 5Liverpool School of Tropical Medicine, Cayetano Heredia, Lima, Peru, 2Lab. Referencial Santa Maria de Nieva, Red de Salud Liverpool, United Kingdom Condorcanqui, Amazonas, Amazonas, Peru

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924 929

TARGET PROTEINS OF THE CYTOSOLIC THIOREDOXIN SEASONAL VARIATION OF PLASMODIUM FALCIPARUM IN PLASMODIUM FALCIPARUM APICAL MEMBRANE ANTIGEN 1 (AMA-1) HAPLOTYPES Shin-ichiro Kawazu1, Hitoshi Takemae2, Kanako Komaki-Yasuda2, Shigeyuki IN CHILDREN LIVING IN MALARIA ENDEMIC AREA OF Kano2 BURKINA FASO 1 National Research Center for Protozoan Diseases, Obihiro University of Agriculture 1 1 1 1 2 Soulama Issiaka , Nebie Issa , Bougouma C. Edith , Diarra Amidou , Sanon and Veterinary Medicine, Hokkaido, Japan, Research Institute, International Medical Souleymane1, Tiono B. Alfred1, Ouedraogo Alphonse1, Yaro B. Jean Baptiste1, Center of Japan, Tokyo, Japan Ouedraogo Espérance1, Gansane Adama1, Lankoande Malik1, Konate T. Amadou1, Sirima B. Sodiomon2 925 1Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso, 2Centre National de Recherche et de Formation sur le Paludisme/Groupe de USE OF MICROSATELLITE MARKERS TO DISTINGUISH Recherche et d’Action en Santé, Ouagadougou, Burkina Faso RECRUDESCENCE FROM REINFECTION IN PLASMODIUM VIVAX INFECTIONS FROM THE PERUVIAN AMAZON 930 BASIN PROTOXIN CRY1AC INDUCES PROTECTION AGAINST P. Valeria R. Soberon1, Carola J. Salas1, Andrea M. McCollum2, Meddly Santolalla1, Salomon Durand1, Venkatachalam Udhayakumar2, Carmen M. BERGHEI ANKA AND P. CHABAUDI AS IN CBA/CA MICE Lucas1, David J. Bacon1 Martha Legorreta-Herrera, Rodrigo Oviedo-Meza, Leticia Moreno- Fierros 1United States Naval Medical Research Center Detachment, Lima, Peru, 2Centers for Universidad Nacional Autonoma de Mexico, Distrito Federal, Mexico Disease Control and Prevention, Malaria Branch, Atlanta, GA, United States (ACMCIP Abstract) (ACMCIP Abstract) 931 926 THE IDENTIFICATION OF MOLECULAR MARKERS FOR GENETIC DIVERSITY ON RE-EMERGED P. VIVAX IN DORMANCY IN PLASMODIUM FALCIPARUM SOUTH AND NORTH KOREA Alexis N. LaCrue, Dennis E. Kyle Yien Kyoung Choi1, Kyung Mi Choi1, Inho Park2, Yeon Joo Kim1, Shin University of South Florida, Tampa, FL, United States Hyung Cho Cho1, Jae Ran Yu1, Jung Yeon Kim1 1National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul, Republic of Korea, 2Armed Forces Seoul Hospital, Seoul, Republic of Korea MALARIA - VACCINES

927 932

LISP1 IS IMPORTANT FOR THE EGRESS OF PLASMODIUM CLINICAL LABORATORY REFERENCE RANGES PARASITES FROM LIVER CELLS DERIVED FROM RURAL POPULATION OF HEALTH Tomoko Ishino1, Bertrand Boisson2, Yuki Orito3, Céline Lacroix2, Emmanuel DISTRICT OF SAPONÉ IN BURKINA FASO DURING 2 2 4 2 3 Bischoff , Céline Loussert , Chris Janse , Robert Ménard , Masao Yuda , MALARIA HIGH TRANSMISSION SEASON Patricia Baldacci2 1 1 1 1 1Ehime University, Toon, Japan, 2Institut Pasteur, Paris, France, 3Mie University, Tsu, Adama Gansane , Amidou Diarra , Souleymane Sanon , Issiaka Soulama , 1 1 1 1 Japan, 4Leiden University Medical Centre, Leiden, The Netherlands Noëlie B. Henry , Amathe Ouedraogo , Alphonse Ouedraogo , Jean B. Yaro , Espérance Ouedraogo1, Andre L. Ouedraogo1, Edith C. Bougouma1, Amadou 1 1 2 1 928 T. Konate , Alfred B. Tiono , Sodiomon B. Sirima , Issa Nebie 1Centre National de Recherche et de Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso, 2Centre National de Recherche et de Formation sur le A HIGHLY SENSITIVE REAL-TIME REVERSE Paludisme (CNRFP), Groupe de Recherche et d’Action en Santé (GRAS), Ouagadougou, TRANSCRIPTION-PCR ASSAY FOR DETECTION OF Burkina Faso PLASMODIUM FALCIPARUM GAMETOCYTES USING A SINGLE AMPLIFICATION STEP 933 Laura Dickson1, Ann Stewart2, Shirley Luckhart1 1University of California, Davis, Davis, CA, United States, 2United States Military A POTENT MALARIA TRANSMISSION BLOCKING Malaria Vaccine Program, United States Army Medical Research Unit-Kenya, Kisumu, VACCINE BASED ON CODON-HARMONIZED PFS48/45 Kenya Debabani Roy Chowdhury1, Evelina Angov2, Thomas Kariuki3, Nirbhay Kumar1 1

Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United Saturday, November 21 States, 2Walter Reed Army Institute of Research, Silver Spring, MD, United States, 3Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya

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934 940

ABNORMALITIES OF HAEMOGLOBIN AND PLASMODIUM DEVELOPMENT OF A RECOMBINANT VACCINE BASED FALCIPARUM MALARIA IN UNDER FIVE CHILDREN ON THE CIRCUMSPOROZOITE PROTEIN (CSP) OF LIVING IN A HIGH AND SEASONAL MALARIA PLASMODIUM FALCIPARUM TRANSMISSION AREA OF BURKINA FASO Jennifer Carter, Joshua Clayton, Aline Alexanian, Evelina Angov, Sheetij Edith C. Bougouma1, Alfred Tiono1, Amidou Diarra1, Alphonse Ouedraogo1, Dutta Issiaka Soulama1, Adama Gansane1, Jean Baptiste Yaro1, Espérance Walter Reed Army Institute of Research, Silver Spring, MD, United States Ouédraogo1, Souleymane Sanon1, Malick Lankouande1, Amadou T. Konaté1, Issa Nébié1, Sodiomon B. Sirima2 941 1Centre National de Recherche et de Formation sur le Paludisme(CNRFP), Ouagadougou, Burkina Faso, 2Centre National de Recherche et de Formation sur le ROUTES OF MALARIA VACCINE AND CHALLENGE Paludisme(CNRFP)/Groupe de Recherche et d’Action en Santé, Ouagadougou, Burkina ADMINISTRATION: TRANSITION FROM MOSQUITO TO Faso NEEDLE AND SYRINGE 935 Nicole M. Thomas1, Judith Epstein1, Sumana Chakravarty2, Stephen L. Hoffman2 1 CELL TRAVERSAL PROTEIN FOR OOKINETES AND Naval Medical Research Center, United States Military Malaria Vaccine Program, Silver Spring, MD, United States, 2Sanaria Incorporated, Rockville, MD, United States SPOROZOITES (CELTOS) FROM P. FALCIPARUM ELICITS PROTECTIVE IMMUNITY IN MICE AGAINST 942 HETEROLOGOUS CHALLENGE WITH P. BERGHEI Elke S. Bergmann-Leitner, Kari M. Laquer, Elizabeth H. Duncan, Tatyana ENTOMOLOGICAL SUPPORT FROM PERU TOWARD Savranskaya, Ryan M. Mease, Mark E. Polhemus, Christian F. Ockenhouse, DEVELOPMENT OF A SAFE AND REPRODUCIBLE Evelina Angov PLASMODIUM VIVAX CHALLENGE SYSTEM IN THE U.S. Walter Reed Army Institute of Research, Silver Spring, MD, United States MILITARY MALARIA VACCINE PROGRAM 936 Paul C. Graf1, Kirk D. Mundal1, Carmen M. Lucas1, David J. Bacon1, Benjamin J. Espinosa1, Arturo Alvarado2, Rosa Santillan Vadivia2, Lourdes 3 3 2 INACTIVATED ESCHERICHIA COLI EXPRESSING Jimenez Campos , Rommel Garrido Gonzales , Walter Vegas Olaya , Edwar Pozo Suclupe2, Chris F. Ockenhouse4, Thomas L. Richie5, David J. Fryauff5 PLASMODIUM BERGHEI CSP EXPRESSED FROM 1Naval Medical Research Center Detachment, Lima, Peru, 2Sub Region of Health DIFFERENT CELLULAR LOCALIZATIONS INDUCE Luciano Castillo Colonna, Sullana, Peru, 3Bellavista Health Center, Sullana, Peru, DIFFERENTIAL IMMUNITY 4Walter Reed Army Institute of Research, Silver Spring, MD, United States, 5Naval Elizabeth Deriso1, Elke S. Bergmann-Leitner1, Jessica Whittington2, Medical Research Center, Silver Spring, MD, United States Elizabeth H. Duncan1, Katharine Boyle1, Tatyana Savranskaya1, Timothy Alefantis2, Paul Grewal2, Vito DelVecchio2, Evelina Angov1 943 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2Vital Probes, Inc., Mayfi eld, PA, United States PFMSP3 N-TERMINUS AS A VACCINE TARGET: CROSS-REACTIVE ANTIBODIES IN A HYPOENDEMIC 937 TRANSMISSION ENVIRONMENT Stephen J. Jordan1, Ana L. Oliveira1, Robert A. Oster1, Oralee H. Branch2, HETEROLOGOUS PRIME-BOOST STRATEGIES USING Julian C. Rayner3 1 2 DIFFERENT ALLELES OF MSP142 TO OVERCOME University of Alabama at Birmingham, Birmingham, AL, United States, New ALLELE-SPECIFIC IMMUNITY York University, New York, NY, United States, 3Wellcome Trust Sanger Institute, Evelina Angov, Elizabeth H. Duncan, Kari M. Laquer, Ryan M. Mease, Elke Cambridge, United Kingdom S. Bergmann-Leitner Walter Reed Army Institute of Research, Silver Spring, MD, United States 944

938 IDENTIFICATION OF NOVEL BLOOD-STAGE VACCINE CANDIDATES AGAINST PLASMODIUM FALCIPARUM BY EFFECT OF HISTIDINE AFFINITY TAGS ON PLASMODIUM HIGH-THROUGHPUT IMMUNOSCREENING FALCIPARUM MSP1-42 PROTEIN STRUCTURE AND Satoru Takeo1, Hirokazu Sakamoto1, Takamasa Kaneko1, Mayumi INDUCTION OF IMMUNITY Tachibana1, Kazutoyo Miura2, Sudhir Varma3, Jetsumon Sattabongkot4, 1 1 1 1 2 1 Motomi Torii , Takafumi Tsuboi Farhat Khan , Ryan M. Mease , Patricia Legler , Elke S. Bergmann-Leitner , 1 2 Evelina Angov1 Ehime University, Ehime, Japan, Malaria Vaccine Development Branch/National 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2Walter Institute of Allergy and Infectious Diseases/National Institutes of Health, Rockville, MD, 3 Reed Army Institute of Research, Biochemistry, Silver Spring, MD, United States United States, BCBB/National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, MD, United States, 4Armed Forces Research Institute of the Medical Sciences, Bangkok, Thailand 939

IMMUNOGENECITY OF APICAL MEROZOITE ANTIGEN-1 CONJUGATES IN MICE Christopher G. Rowe, David S. Jones, David Narum, Rich Shimp, Karine Reiter, Kelly Rausch, Emma Barnafo, Lynn Lambert, Kazutoyo Miura, Joan Aebig, Feng Qian, Louis Miller Malaria Vaccine Development Branch, Rockville, MD, United States

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MOSQUITOES – BIOCHEMISTRY AND 952 MOLECULAR BIOLOGY BIOMARKERS OF PHYSIOLOGICAL AGE IN ANOPHELES STEPHENSI 945 Vanessa Corby-Harris, Michael A. Riehle University of Arizona, Tucson, AZ, United States ANOPHELES STEPHENSI D7 L: A SALIVARY GLAND PROTEIN WITH BOTH ANTI-INFLAMMATORY AND 953 ANTIHEMOSTATIC EFFECT Patricia H. Alvarenga, Eric Calvo, Ivo M. Francischetti, Anderson Sa-Nunes, THE MOSQUITO HOMOLOGUE OF METHOPRENE- Jose Marcos Ribeiro, John F. Andersen TOLERANT PROTEIN IS A TRANSCRIPTIONAL National Institute of Allergy and Infectious Diseases/National Institutes of Health, REGULATOR MODULATED BY INSECT JUVENILE Rockville, MD, United States HORMONE 946 Jinsong Zhu, Meng Li, Jeff Busche, Xing Zhang Virginia Tech, Blacksburg, VA, United States

ROLE OF GLUTAMINE SYNTHETASE AND GLUTAMATE 954 SYNTHASE (GS/GLTS) IN AEDES AEGYPTI FAT BODY METABOLISM MOLECULAR BASIS OF THE ESSENTIAL AMINO ACID Patricia Scaraffi a, Vicki Wysocki, Roger Miesfeld ABSORPTION IN VECTOR MOSQUITOES University of Arizona, Tucson, AZ, United States Dmitri Y. Boudko1, Melissa M. Miller2, Dmitry A. Voronov3, Ella A. Meleshkevitch1 947 1Rosalind Franklin University, North Chicago, IL, United States, 2The Whitney Laboratory, University of Florida, St. Augustine, FL, United States, 3Institute for MOLECULAR ANALYSIS OF PROTEASE FUNCTION Information Transmission Problems, Russian Academy of Sciences, Moscow, Russian IN THE MIDGUT OF BLOOD FED AEDES AEGYPTI Federation MOSQUITOES 955 Jun Isoe, Alberto Rascon, Susan Kunz, Roger Miesfeld University of Arizona, Tucson, AZ, United States PROTEOLYTIC PROCESSING OF ANOPHELES SGS: 948 CANDIDATE RECEPTORS FOR SALIVARY GLAND INVASION BY PLASMODIUM SPOROZOITES BIOCHEMICAL ANALYSIS OF BLOOD MEAL-INDUCED Jonas G. King, Julián F. Hillyer MIDGUT PROTEASES IN AEDES AEGYPTI MOSQUITOES Vanderbilt University, Nashville, TN, United States Alberto Rascon, Jun Isoe, Roger Miesfeld University of Arizona, Tucson, AZ, United States 956

949 EFFECTS OF HUMAN IGF1 ON INSULIN SIGNALING IN THE MALARIA VECTOR ANOPHELES STEPHENSI FATTY ACID SYNTHASE (FAS1) AND THE CD36 FATTY Anna Drexler, Kong Cheung, Nazzy Pakpour, Shirley Luckhart ACID TRANSPORT PROTEIN ARE REQUIRED FOR University of California, Davis, Davis, CA, United States THE CONVERSION OF BLOOD MEAL PROTEINS INTO (ACMCIP Abstract) STORED LIPIDS IN AEDES AEGYPTI MOSQUITOES Amy Alabaster, James Morton, Roger Miesfeld MOSQUITOES – MOLECULAR GENETICS University of Arizona, Tucson, AZ, United States 957 950 GENETIC STRUCTURE OF AEDES AEGYPTI (DIPTERA: AN RNAI-BASED FORWARD GENETIC TOOL FOR CULICIDAE) USING MICROSATELLITE AND ANALYSIS OF MOSQUITO CELLULAR RESPONSES TO MITOCHONDRIAL MARKERS IN CAMEROON (CENTRAL DENGUE VIRUS INFECTION AFRICA) Baojun Yang, Qi Li, C. Bruce Cropp, Hongwei Li 1 2 3 2 University of Hawaii, Honolulu, HI, United States Basile Kamgang , Cécile Brengues , Frédéric Simard , Jean Pierre Herve , Saturday, November 21 1 (ACMCIP Abstract) Christophe Paupy 1Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale, Yaoundé, Cameroon, 2Institut de Recherche pour le Développement, Montpellier, France, 951 3Institut de Recherche pour le Développement, Bobo-Dioulasso, Burkina Faso

INSULIN SIGNALING IN THE MIDGUT OF AN. STEPHENSI MOSQUITOES IMPACTS LIFESPAN Michael A. Riehle, Laurel Watkins de Jong, Vanessa Corby-Harris, Rolf Ziegler University of Arizona, Tucson, AZ, United States

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MICROGEOGRAPHIC GENETIC DIVERSITY OF THE PHYLOGENETIC RELATIONSHIP AND POPULATION MALARIA VECTOR ANOPHELES DARLINGI FROM STRUCTURE OF THE NEOTROPICAL MALARIA VECTOR CORDOBA AND ANTIOQUIA, COLOMBIA ANOPHELES MARAJOARA (DIPTERA: CULICIDAE) USING Lina A. Gutiérrez1, Giovan F. Gómez1, John J. González2, Martha I. Castro2, MULTIPLE MOLECULAR MARKERS Shirley Luckhart3, Jan E. Conn4, Margarita M. Correa1 S. N. McKeon1, M. A. Lehr2, C. W. Kilpatrick2, R. C. Wilkerson3, M. A. 1Grupo de Microbiología Molecular, Escuela de Microbiología, Universidad de Sallum4, J. B. Pereira5, J. E. Conn6 Antioquia, Medellín, Colombia, 2Unidad de Entomología, Laboratorio de Salud Pública, 1School of Public Health, State University of New York-Albany, Slingerlands, NY, Departamento de Córdoba, Montería, Colombia, 3Department of Medical Microbiology United States, 2College of Arts and Sciences, University of Vermont, Burlington, VT, and Immunology, University of California, Davis, CA, United States, 4Griffi n United States, 3Walter Reed Army Institute of Research, Smithsonian Institution, Laboratory, Wadsworth Center, New York State Department of Health, Albany, NY, Washington, DC, United States, 4Faculdade de Saúde Pública, Universidade de Sao United States Paulo, Sao Paulo, Brazil, 5Laboratorio de Fisiologia e Controle de Artropodes Vetores, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil, 6The Wadsworth Center, Griffi n 959 Laboratory, New York State Department of Health, Albany, NY, United States

MOSQUITO VISION: MOLECULAR EVOLUTION AND 964 FUNCTIONAL CHARACTERIZATION OF THE OPSINS IN ANOPHELES GAMBIAE AND AEDES AEGYPTI MOLECULAR ANALYSIS OF THE ANOPHELES GAMBIAE Gloria I. Giraldo-Calderon, Michael J. Zanis, Catherine A. Hill S.S. CHROMOSOME 2RB INVERSION DISTAL Purdue University, West Lafayette, IN, United States BREAKPOINT AREA (ACMCIP Abstract) Djibril M. Sangare1, Neil F. Lobo2, Maria Sharakhova3, Maria Unger2, Sekou F. Traore1, Nora J. Besansky2, Frank H. Collins2 960 1MRTC/FMPOS, Bamako, Mali, 2Eck Institute for Global Health, University of Notre Dame, South Bend, IN, United States, 3University of Virginia Tech, Blacksburg, VA, POPULATION DEMOGRAPHY OF MALARIA VECTOR United States ANOPHELES (ANOPHELES) PSEUDOPUNCTIPENNIS FROM 965 ARGENTINA

1 2 2 María J. Dantur Juri , Monica J. Prado Izaguirre , Juan C. Navarro , LINEAGE DIVERGENCE IN THE NEOTROPICAL Guillermo L. Claps1, Jan E. Conn3 1Instituto Superior de Entomologia, Facultad de Ciencias Naturales e I.M.L., MALARIA VECTOR ANOPHELES (NYSSORHYNCHUS) Universidad Nacional de Tucumán, San Miguel de Tucumán- Tucumán, Argentina, NUNEZTOVARI AND ITS SISTER TAXON AN. GOELDII 2Laboratorio de Biología de Vectores, Instituto de Zoología Tropical, Universidad Central (DIPTERA: CULICIDAE) BASED ON NUCLEAR WHITE de Venezuela, Caracas, Venezuela, 3Griffi n Laboratory, Wadsworth Center, New York AND MTDNA COI SEQUENCE ANALYSIS State Department of Health, Albany, NY, United States Richard C. Wilkerson1, Victoria Spindler2, Maria Anice Sallum3, Marinete M Povoa4, Margarita M. Correa5, Lina A. Gutierrez5, Yadira Rangel6, Jan E. 961 Conn7 1Walter Reed Army Institute for Research, Smithsonian Institution, Washington, DC, GENE EXPRESSION PROFILE ASSOCIATED WITH United States, 2School of Public Health, SUNY-Albany, Albany, NY, United States, BLOOD FEEDING AND PLASMODIUM FALCIPARUM 3Faculdade de Saude Publica, Universidade de Sao Paulo, Sao Paulo, Brazil, 4Programa INFECTION IN THE MALARIA VECTOR ANOPHELES de Pesquisas em Malaria, Instituto Evandro Chagas, Belem, Brazil, 5Escuela de 6 FUNESTUS Microbiologia, Universidad de Antioquia, Medellin, Colombia, Instituto de Zoologia Tropical, Universidad Central de Venezuela, Caracas, Venezuela, 7The Wadsworth Mamadou B. Coulibaly1, Brehima Diallo1, Amadou Guindo1, Mohamed M. Center, New York State Department of Health, Albany, NY, United States Traore1, Sekou A. Traore1, Mamadou Konate1, Jennifer M. Anderson2, Neil F. Lobo3, Nora J. Besansky3, Jose M. Ribeiro2, Sekou F. Traore1 966 1Malaria Research and Training Center, Bamako, Mali, 2National Institutes of Health, Bethesda, MD, United States, 3University of Notre Dame, Notre Dame, IN, United States POPULATION CYTOGENETICS OF ANOPHELES MOUCHETI AND ANOPHELES NILI 962 Maria Sharakhova1, Christophe Antonio-Nkondjio2, Frederic Simard3, Igor Sharakhov1 ROBUST SALIVARY GLAND-SPECIFIC GENE 1Virginia Tech, Blacksburg, VA, United States, 2Malaria Research Laboratory OCEAC, Yaounde, Cameroon, 3Institut de Recherche en Sciences de la Santé (IRSS), Bobo- EXPRESSION IN TRANSGENIC AEDES AEGYPTI: Dioulasso, Burkina Faso DIVERGENT EXPRESSION OF TWO TRANSGENES DRIVEN BY A BI-DIRECTIONAL PROMOTER Geetika Mathur, Osvaldo Marinotti, Danielle Alvarez, Anthony A. James University of California Irvine, Irvine, CA, United States

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MOSQUITOES – VECTOR BIOLOGY- 973 EPIDEMIOLOGY OPTIMIZATION OF AN AUTOMATED COUNTING DEVICE FOR USE IN VECTOR BEHAVIOR STUDIES 967 Monthathip Kongmee1, Philipp Kirsch2, Hortance Manda3, John Grieco3, Theeraphap Chareonviriyaphap1, Nicole Achee3 IRRITANT AND REPELLENT BEHAVIORAL RESPONSES 1Katsetsart University, Bangkok, Thailand, 2Aptiv Inc., Portland, OR, United States, OF AEDES AEGYPTI MALE POPULATIONS DEVELOPED 3Uniformed Services University of the Health Sciences, Bethesda, MD, United States FOR RIDL® DISEASE CONTROL STRATEGIES 974 Nicole Achee1, Monthathip Kongmee2, Cecilia Coscaron-Arias1, John Grieco1, Camilla Beech3, Derric Nimmo3, Luke Alphey3, Ann Kramer3 1Uniformed Services University of the Health Sciences, Bethesda, MD, United States, STRUCTURE AND PUTATIVE FUNCTIONS OF THE 2Kasetsart University, Bangkok, Thailand, 3Oxitec, Oxford, United Kingdom ANTERIOR AND POSTERIOR LARVAL INTIMAL REMNANTS IN THE MOSQUITO ALIMENTARY CANAL 968 Christine E. Leistner1, Kriangkrai Lerdthusnee2, William S. Romoser3 1International Development Studies, Ohio University, Athens, OH, United States, MOSQUITOMAP AND THE MAL-AREA CALCULATOR: 2Department of Entomology, Armed Forces Institute of Medical Research, Bangkok, NEW WEB RESOURCES FOR GLOBAL MOSQUITO Thailand, 3Tropical Disease Institute, OUCOM, Ohio University, Athens, OH, United SPECIES DISTRIBUTION AND VECTOR-BORNE DISEASE States RISK ASSESSMENT 975 Desmond H. Foley, Richard C. Wilkerson Walter Reed Army Institute of Research, Suitland, MD, United States EVALUATION OF AEDES AEGYPTI RESTING 969 PREFERENCES IN EXPERIMENTAL HUTS IN IQUITOS, PERU TARGETED METHOD FOR THE DETECTION OF Fanny Castro-Llanos1, Hortance Manda2, Amy Morrison1, Victor Lopez1, 2 2 3 EASTERN EQUINE ENCEPHALITIS VIRUS FROM Nicole L. Achee , John Grieco , Kirk Mundal 1United States Naval Medical Research Center Detachment, Iquitos, Peru, 2Uniformed MOSQUITOES IN FLORIDA Services University of the Health Sciences, Bethesda, MD, United States, 3United States Christy L. Ottendorfer1, Gregory S. White2, Hassan K. Hassan1, Kevin J. Naval Medical Research Center Detachment, Lima, Peru Hill1, Lillian M. Stark3, Thomas R. Unnasch1 1GHIDR Program, University of South Florida, Tampa, FL, United States, 2University 976 of Alabama at Birmingham, Birmingham, AL, United States, 3Florida Department of Health, Bureau of Laboratories-Tampa, Tampa, FL, United States SUSCEPTIBILITY OF AE. AEGYPTI TO ORAL INFECTION 970 WITH MAYARO VIRUS Kanya C. Long, Charles E. McGee, Konstantin A. Tsetsarkin, Stephen Higgs, A SURVEY OF TWO SPECIES IN THE MINIMUS GROUP Robert B. Tesh University of Texas Medical Branch, Galveston, TX, United States FROM MALARIA ENDEMIC AREAS IN WESTERN THAILAND 977 Monthathip Kongmee1, Nicole Achee2, Penny Masuoka2, Theeraphap 1 Chareonviriyaphap THE RELATIONSHIP BETWEEN HOST ABUNDANCE 1Kasetsart University, Bangkok, Thailand, 2Uniformed Services University of the Health Sciences, Bethesda, MD, United States AND PER-HOST FEEDING DENSITY OF CULEX QUINQUEFASCIATUS SAY (DIPTERA: CULICIDAE) 971 Ivo M. Foppa1, Jerrilynn L. Moore1, Ricardo Cortez1, Angela C. Gallegos2, Dawn M. Wesson1 1 2 ANOPHELES ARABIENSIS FEEDING BEHAVIOR AND Tulane University, New Orleans, LA, United States, Occidental College, Los Angeles, CA, United States ITS RELATIONSHIP TO THE DEMOGRAPHICS OF INSECTICIDE-TREATED BED NET USE IN MACHA, 978 ZAMBIA Douglas E. Norris, Laura C. Norris, Christen M. Fornadel EFFECT OF DENGUE II VIRUS INFECTION ON PROTEIN Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States EXPRESSION IN THE HEAD AND THORAX OF AEDES

AEGYPTI MOSQUITOES Saturday, November 21 972 Christopher N. Mores, Daniel M. Chisenhall Louisiana State University, Baton Rouge, LA, United States EVIDENCE OF PASSIVE DISPERSAL OF ANOPHELES GAMBIAE IN THE EARLY ADULT PHASE 979 Nicholas C. Manoukis1, Nafomon Sogoba2, Moussa Diallo2, José M. Ribeiro1 1 Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious ENVIRONMENTAL FACTORS ASSOCIATED WITH THE Diseases/National Institutes of Health, Bethesda, MD, United States, 2Malaria Research and Training Center, Faculty of Medicine, Bamako, Mali MALARIA VECTORS ANOPHELES GAMBIAE S.L AND ANOPHELES FUNESTUS IN KENYA Louise A. Kelly-Hope1, F. Ellis McKenzie2 1Liverpool School of Tropical Medicine, Liverpool, United Kingdom, 2Fogarty International Center, National Institutes of Health, Bethesda, MD, United States

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TEMPORAL ASSOCIATIONS BETWEEN CULEX PITFALLS IN DIAGNOSING CNS TUBERCULOSIS TARSALIS ABUNDANCE AND WESTERN EQUINE Deborah Asnis, Tamar Toronjadze, Robert Rilpuou, Anil Kapoor, Jordan A ENCEPHALOMYELITIS VIRUS TRANSMISSION Kazakov, Chiminyan Sathyakumar Flushing Hospital Medical Center, Flushing, NY, United States Christopher M. Barker1, Bruce F. Eldridge1, Wesley O. Johnson2, Bborie K. 1 1 Park , William K. Reisen 987 1University of California, Davis, CA, United States, 2University of California, Irvine, CA, United States MOLECULAR CHARACTERIZATION OF HUMAN 981 METAPNEUMOVIRUS ISOLATES FROM PERU, HONDURAS AND COLOMBIA: 2008-2009 UNDERSTANDING THE EFFECTS OF CLIMATE ON Maria E. Gamero1, Merly Sovero1, Josefi na Garcia1, Jane Rios1, Ivette MALARIA TRANSMISSION Lorenzana2, Ana E. Arango3, Victor Ocaña4, Gloria Chauca1, Jose L. Huaman1, V. Alberto Laguna-Torres1, Patricia V. Aguilar1, Tadeusz Kochel1 Krijn Paaijmans, Simon Blanford, Andrew Bell, Andrew Read, Matthew 1Naval Medical Research Center Detachment, Lima, Peru, 2Universidad Nacional Thomas Autonoma de Honduras, Tegucigalpa, Honduras, 3Grupo de Inmunologia, Universidad Pennsylvania State University, University Park, PA, United States de Antioquia, Medellin, Colombia, 4Centro de Salud Pachitea/Ministerio de Salud, Piura, Peru 982 988 BITING BEHAVIOR OF ANOPHELES MINIMUS THEOBALD (DIPTERA:CULICIDAE) IN NORTHERN PROVINCE, A DF152 AS A NEW MOLECULE TO TREAT TUBERCULOSIS SITE OF HIGH MALARIA INCIDENCE IN THAILAND AND OTHER NEGLECTED MYCOBACTERIAL Wannapa Suwonkerd1, Nanatawan Suwannachote1, Theeraphap INFECTIONS Chareonviriyaphap2 Anny Fortin1, Shahid Soomro1, Paul Stoppie1, Sarah Cauwenbergh1, Sabine 1Offi ce of Disease Prevention and Control, Ministry of Public Health, Chiang Mai, Ruesch-Gerdes2, Frans Herwig Jansen1 Thailand, 2Faculty of Entomology, Department of Agriculture, Kasetsart University, 1Dafra Pharma R&D bvba, Turnhout, Belgium, 2National Reference Center for Bangkok, Thailand Mycobacteria, Research Center Borstel, Borstel, Germany (ACMCIP Abstract) 989 983 ASSOCIATION BETWEEN HTLV-1 INFECTION AND COMPARATIVE KINETICS OF SOUTHEAST ASIAN TUBERCULOSIS: EPIDEMIOLOGICAL AND CLINICAL DENGUE VIRUSES WITHIN AND BETWEEN SEROTYPES ASPECTS Rebecca C. Christofferson, Christopher N. Mores 1 2 3 Louisiana State University, Baton Rouge, LA, United States Maria de Loudes S. Bastos , Beth Osterbauer , Daniel L. Mesquita , Carlos A. Carreira3, Maria Juliana Albuquerque3, Leandro Silva3, Daniele N. Pereira3, Lee Riley2, Edgar M. Carvalho4 984 1Hospital Especializado Octavio Mangabeira, Salvador - BA, Brazil, 2University of California at Berkley, Berkley, CA, United States, 3Escola Bahiana de Medicina e Saúde EVALUATION OF A NEW LONG LASTING INSECTICIDAL Pública, Salvador - BA, Brazil, 4Federal University of Bahia, Salvador - BA, Brazil NET (NETPROTECT®) ON INDOOR RESTING ACTIVITY AND ON HUMAN MALARIA INCIDENCE IN VILLAGES IN 990 WESTERN KENYA Ojera Odhiambo1, John Vulule2, L. Odeny2, N. Mulaya2, E. D. Kokwaro2, IDENTIFICATION OF ENTEROVIRUS ISOLATIONS IN Ole Skovmand3 CHILDREN WITH INFLUENZA-LIKE ILLNESS IN SOUTH 1Kenyatta University, Nairobi, Kenya, 2KEMRI, Kisumu, Kenya, 3Intelligent Insect AMERICA Control, Castelnau le Lez, France Jose L. Huaman1, Maria E. Gamero1, Ana E. Arango2, Washington Aleman3, Wilson Chicaiza4, Gloria Rey5, Nicolas Aguayo6, Guillermo Comach7, Cecilia PNEUMONIA, RESPIRATORY INFECTIONS Rivera1, Gloria Chauca1, V. Alberto Laguna-Torres1, Melvin Barrantes8, Tadeusz Kochel1 AND TUBERCULOSIS 1Naval Medical Research Center Detachment, Lima, Peru, 2Grupo de Inmunovirologia, Universidad de Antioquia, Medellin, Colombia, 3Hospital Vernaza, Guayaquil, Ecuador, 4Hospital Vozandes, Quito, Ecuador, 5Instituto Nacional de Salud, Bogota, Colombia, 985 6Asociacion Rayos de Sol, Asuncion, Paraguay, 7Laboratorio Regional de Diagnostico e Investigación del Dengue y otras Enfermedades Virales, Maracay, Venezuela, 8Hospital CD36 DEFICIENCY AND RESISTANCE TO Materno Infantil San Francisco Solano, Buenos Aires, Argentina MYCOBACTERIAL INFECTION Michael Hawkes, Xiaoming Li, Maryanne Crockett, Angelina Diassiti, Constance Finney, Gundula Min-Oo, W. Conrad Liles, Jun Liu, Kevin Kain University of Toronto, Toronto, ON, Canada

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991 997

THE PITFALLS IN DIAGNOSING CENTRAL NERVOUS CHIKUNGUNYA VIRUS ANTIBODY IN TRAVELERS SYSTEM MENINGITIS Natasha K. Soodoo1, Elizabeth D. Barnett1, Abbie Stevenson1, Stephen I. Robert Rilpuou, Deborah Asnis, Tamar Toronjadze, Jordan Kazakov Pelton1, Emad Yanni2, Nina Marano2, Lin H. Chen3, Mary E. Wilson4, Winnie Flushing Hospital Medical Center, Flushing, NY, United States W. Ooi5, Laura Kogelman6, Adolf W. Karchmer7, Davidson H. Hamer8 1Boston Medical Center, Boston, MA, United States, 2Centers for Disease Control and 992 Prevention, Atlanta, GA, United States, 3Mount Auburn Hospital, Cambridge, MA, United States, 4Harvard School of Public Health, Boston, MA, United States, 5Lahey Clinic, Burlington, MA, United States, 6Tufts Medical Center, Boston, MA, United DEVELOPMENT OF A SINGLE DOSE, POX-VIRUS BASED States, 7Beth Israel Deaconess, Boston, MA, United States, 8Boston University School of VACCINE FOR HIGHLY VIRULENT AVIAN INFLUENZA Public Health, Boston, MA, United States VIRUSES (H5N1) Jeremy C. Jones1, Tim D. Powell2, Brock Bakke3, Joseph N. Brewoo1, 998 Charalambos D. Partidos1, Dan T. Stinchcomb2, Jorge E. Osorio3 1Inviragen, Inc., Madison, WI, United States, 2Inviragen, Inc., Fort Collins, CO, United ARBOVIRUSES CIRCULATING IN BOLIVIA 2008 - 2009 States, 3University of Wisconsin, Madison, WI, United States E. Roxana Caceda1, Juan Sulca1, Patricia V. Aguilar1, Jorge Vargas2, Yelin Roca2, Carolina Guevara1, Tadeusz Kochel1 993 1Naval Medical Research Center Detachment, Lima, Peru, 2Centro Nacional de Enfermedades Tropicales, Santa Cruz, Bolivia ANTIBIOTIC SUSCEPTIBILITY AND SEROTYPES OF STREPTOCOCCUS PNEUMONIAE FROM INVASIVE DISEASE 999 IN RURAL THAILAND, 2005-2009 Prasert Salika1, Leelaowadee Sangsuk2, Possawat Jorakate1, Anek Kaewpan1, CELLULAR RESPONSE TO RIFT VALLEY FEVER VIRUS Duangkamon Siludjai1, Sopida Pookit2, Surang Dejsirilert2, Sumalee INFECTION Boonmar1, Leonard Peruski1 Kimberly K. Gray, Michael R. Holbrook 1International Emerging Infections Program, Nonthaburi (Bangkok), Thailand, University of Texas Medical Branch, Galveston, TX, United States 2National Institute of Health, Ministry of Public Health, Nonthaburi (Bangkok), Thailand 1000 994 MATERNAL AND NEONATAL DEATHS ASSOCIATED WITH ACUTE JAUNDICE DURING PREGNANCY IN SENTINEL HUMAN SURVEILLANCE FOR INFLUENZA AT BANGLADESH: USING VERBAL AUTOPSY DATA HEALTH CARE FACILITIES IN KATHMANDU TO ESTIMATE OF THE BURDEN OF HEPATITIS E 1 2 2 1 Sanjaya K. Shrestha , Julie A. Pavlin , Khin S. Myint , Bishnu K. Shrestha , INFECTION Robert V. Gibbons2, Binob Shrestha1, Kittinun Hussem2, Bishnu B. Rayamajhi1, Richard G. Jarman2 Emily Gurley, Amal K. Halder, Peter K. Streatfi eld, H. M. Shahed Sazzad, 1Walter Reed/AFRIMS Research Unit Nepal, Kathmandu, Nepal, 2Armed Forces M. Tarique Huda, M. Jahangir Hossain, Stephen P. Luby Research Institute of Medical Sciences, Bangkok, Thailand International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

VIRUSES - OTHER 1001 EMERGING VIRAL ZOONOSES IN AZERBAIJAN: A 995 CROSS-SECTIONAL STUDY Danielle V. Clark1, Afrail Ismayilov2, Esmiralda Seyidova2, Ayten Hajiyeva3, EMERGENCE OF DENGUE VIRUS SEROTYPE 4 IN Sevinj Bakhishova2, Huseyn Hajiyev2, Tahir Nuriyev4, Saleh Piraliyev4, NORTHERN PERU Sadigulla Bagirov4, Afag Aslanova5, Amanda Lane6, Maqsud Qasimov2, Matthew J. Hepburn6 Brett M. Forshey1, Amy C. Morrison2, Cristhopher Cruz3, Claudio Rocha2, 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2Anti- Stalin Vilcarromero2, Carolina Guevara3, Daria E. Camacho4, Araceli Alava5, Plague Station, Baku, Azerbaijan, 3Republican Veterinary Laboratory, Baku, Cesar Madrid6, Luis Beingolea7, Victor Suarez8, Guillermo Comach4, Tadeusz Azerbaijan, 4Center for Hygiene and Epidemiology, Quba, Qusar, Xachmaz, Azerbaijan, Kochel3 5Raytheon Technical Services Company, Baku, Azerbaijan, 6United States Army 1Naval Medical Research Center Detachment, Lima and Iquitos, Peru, 2Naval Research Institute for Infectious Diseases, Fort Detrick, MD, United States Medical Research Center Detachment, Iquitos, Peru, 3Naval Medical Research Center Detachment, Lima, Peru, 4Laboratorio Regional de Diagnóstico e Investigación del Dengue y otras Enfermedades Virales, Maracay, Venezuela, 5Instituto Nacional de 1002 Higiene y Medicina Tropical “Leopoldo Izquieta Perez”, Guayaquil, Ecuador, 6Hospital Saturday, November 21 Naval de Guayaquil, Guayaquil, Ecuador, 7Direccion General de Epidemiologia/ PHYLOGENY OF EASTERN EQUINE ENCEPHALITIS Ministerio de Salud, Lima, Peru, 8Instituto Nacional de Salud, Lima, Peru VIRUS IN FLORIDA Gregory S. White1, Lillian M. Stark2, Christy L. Ottendorfer3, Thomas R. 996 Unnasch3 1University of Alabama at Birmingham, Birmingham, AL, United States, 2Florida LAGUNA NEGRA VIRUS ASSOCIATED WITH HUMAN Department of Health, Bureau of Laboratories-Tampa, Tampa, FL, United States, ILLNESS IN PARAGUAY 3GHIDR Program, University of South Florida, Tampa, FL, United States Vidal Felices1, Nicolas Aguayo2, V. Alberto Laguna-Torres1, Patricia V. Aguilar1, Cristhopher Cruz2, Ivan Allende3, Alma Barboza2, Tadeusz Kochel1 1Naval Medical Research Center Detachment, Lima, Peru, 2Asociacion Rayos de Sol, Asuncion, Paraguay, 3Ministry of Health, Asuncion, Paraguay

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1003 SCIENTIFIC MANUSCRIPT WRITING Serap Aksoy BASELINE KAP SURVEY: AVIAN INFLUENZA IN Yale University School of Public Health, New Haven, CT, United States THE INCIDENCE AREAS OF TANGERANG, BANTEN PROVINCE, INDONESIA Mid-Day Session 134 Lisa Safi ra, Alyya S. Siregar Faculty of Medicine, Pembangunan Nasional Veteran Jakarta University, Jakarta Video on Cuba’s Role in the Global Health Crisis Selatan, Indonesia Delaware B 1004 Saturday, November 21, 12:15 p.m. - 1:15 p.m.

A COMPARISON OF THE INFECTION DYNAMICS From the shores of Africa to the Americas, the documentary fi lm, !Salud!, OF HOUSE SPARROW AND COTTON RATS WITH hits the road with some of the 28,000 Cuban health professionals serving in 68 countries, and explores the hearts and minds of international medical NORTH AND SOUTH AMERICAN EASTERN EQUINE students in Cuba—now numbering 30,000, including nearly 100 from the ENCEPHALITIS VIRUS USA. Their stories plus testimony from experts around the world bring home Nicole Arrigo1, Douglas M. Watts2, Patrick C. Newman1, Scott C. Weaver1 the competing agendas that mark the battle for global health, and the complex 1University of Texas Medical Branch, Galveston, TX, United States, 2University of realities confronting the movement to make healthcare everyone’s birth right. Texas El Paso, El Paso, TX, United States CHAIR 1005 Peter Bourne MEDICC, Washington, DC, United States DENGUE SMS SURVEILLANCE PROJECT IN THE PHILIPPINES 12:15 p.m. Jacqueline Coberly1, Richard Wojcik1, Agnes D. Tomayao2, IIya A. Tac-an3, VIDEO PRESENTATION John Mark S. Velasco4, Sheri Lewis1 1JHU Applied Physics Laboratory, Laurel, MD, United States, 2USAMC-AFRIMS/ 12:45 p.m. Philippines-AFRIMS Virology Research Unit, Cebu City, Philippines, 3Cebu City Health Department/City Epidemiology Surveillance Statistics Unit, Cebu City, Philippines, DISCUSSION 4PAVRU, Manila, Philippines Meet the Professors 135 Poster Session C ACMCIP Abstracts – Molecular, Cellular and Immunoparasitology Meet the Professors C: Enigmatic and Teaching Cases 617, 621, 623, 626, 630, 632, 637, 638, 643, 646, 753, 755, 758, 782, 819, 820, 824, 840, 842, 846, 857, 861, 866, 868, 879, 888, 889, 892, 901, 910, 912, 913, Virginia C 914, 915, 916, 918, 920, 925, 930, 950, 956, 959, 982 Saturday, November 21, 12:15 p.m. - 1:15 p.m.

Membership Committee Meeting A panel of professors will present one clinical case each of a tropical disease specifi c to a particular region that they have found a challenge to manage or Room 8217 diagnose. If there is time, participants may be able to present enigmatic cases for the audience and panel to consider. Saturday, November 21, 12:15 p.m. - 1:15 p.m. Certifi cate Exam Committee Meeting CHAIR Davidson H. Hamer Room 8212 Boston University School of Public Health, Boston, MA, United States Saturday, November 21, 12:15 p.m. - 1:15 p.m. PANELISTS David Shlim Mid-Day Session 133A Jackson Hole Travel and Tropical Medicine, Jackson Hole, WY, United States Eli Schwartz Workshop on Manuscript Preparation: How to Get Your Tel-Aviv University, Tel-Aviv, Israel Work Published Delaware A Poster Session C Viewing Saturday, November 21, 12:15 p.m. - 1:15 p.m. Exhibit Hall B South Saturday, November 21, 1:30 p.m. - 7 p.m. This workshop is intended for students and junior scientists who are not extensively familiar with manuscript publication processes. The workshop will be interactive and discuss the manuscript submission process and provide tips on how to avoid the most common mistakes.

CHAIR Serap Aksoy Yale University, New Haven, CT, United States Barbara Sina Fogarty International Center, National Institutes of Health, Bethesda, MD, United States

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Symposium 136 in the 60-80 % range. Inputs (i.e., resources invested, commodities procured), actions (i.e., teams organized, people trained, districts engaged) and outputs (i.e., prevention interventions [ITNs, and IRS] and diagnostics and drugs Progress Towards Predicting and Preventing Outbreaks of distributed) have grown steadily, especially in the past three years. Outcomes Vector-Borne Disease Utilizing Satellite Remote Sensing (i.e., increasing nationwide coverage of interventions) have similarly improved Technology and Models dramatically in successive years. The declaration of expanded ambitions for malaria control, including elimination and eradication, poses a new set of Salon 1 programming. SUFI has proven to be a coherent framework for launching national malaria control programming, but does not constitute a sustainable Saturday, November 21, 1:30 p.m. - 3:15 p.m. approach longer-term to maintain malaria burden at low levels or elimination. The symposium is designed to update the progress in the using Remote The transition from a campaign approach to programming for sustained Sensing to predict and mitigate vector-borne disease. The speakers will discuss impact creates new criteria of program success. National program competency models developed by NASA and their partners for application of the research to maintain low malaria transmission and burden, the capacity to defi ne results for improved prevention and prediction of outbreaks. We will discuss highly cost-effi cient program strategies and to assure fi nancing loom as major new fi nding from the projects that were introduced last year and also present challenges. National experiences in planning for sustained impact on malaria new projects that are using NASA data. will build our collective knowledge on how countries in the Africa region can not only realize, but also sustain, low malaria burden. CHAIR CHAIR Sue M. Estes NASA/USRA, Huntsville, AL, United States Carlos C. (Kent) Campbell PATH Malaria Control and Evaluation Partnership in Africa (MACEPA), Seattle, 1:30 p.m. WA, United States AN UPDATE OF NASA PUBLIC HEALTH APPLICATIONS 1:30 p.m. PROJECTS USING REMOTE SENSING DATA OPENING REMARKS Sue M. Estes David Brandling-Bennett NASA/USRA, Huntsville, AL, United States Bill & Melinda Gates Foundation, Seattle, WA, United States 1:55 p.m. 1:40 p.m. ROLES OF REMOTE SENSING AND GIS IN AVIAN AND ZAMBIA: STRATEGIES TO SUSTAIN THE PROGRAM PANDEMIC INFLUENZA SURVEILLANCE AND RISK IMPACT ACHIEVED THROUGH SUFI PREDICTION Elizabeth Chizema Richard Kiang Ministry of Health, Lusaka, Zambia NASA, Greenbelt, MD, United States 2 p.m. 2:20 p.m. ETHIOPIA: DEVELOPMENT OF A RISK STRATIFIED ENHANCING MALARIA EARLY WARNING SYSTEMS APPROACH TO FOCUS PROGRAM AND PREVENTING (MEWS) WITH EARTH OBSERVATION AND MODELING RESURGENCE RESULTS Kesetebirhan Admasu Stephen Connor Federal Ministry of Health, Addis Ababa, Ethiopia International Research Institute for Climate and Society (IRI), New York, NY, United States 2:25 p.m. 2:45 p.m. SWAZILAND: PROGRAMMING WITH NEIGHBORING COUNTRIES TO SUSTAIN MALARIA CONTROL AND MOSQUITO-BORNE ENCEPHALITIS VIRUS ELIMINATION INTEGRATION USING REMOTE SENSING FOR INTERVENTION DECISION SUPPORT SYSTEMS Simon Kunene Ministry of Health, Manzini, Swaziland William K. Reisen University of California - Davis, Davis, CA, United States 2:50 p.m. Symposium 137 DONORS AND TECHNICAL AGENCIES – SUPPORTING PLANNING, IMPLEMENTATION, AND FINANCING FOR SUSTAINED IMPACT Malaria Control in Africa for Sustained Impact: Mapping Duncan Earle Saturday, November 21 the Transition from Program Scale-up to Elimination PATH, Ferney, France Salon 2 Saturday, November 21, 1:30 p.m. - 3:15 p.m.

Scale-up for Impact (SUFI) has served as a framework for national program implementation, with an emphasis on rapid national-scope attainment of high prevention coverage with documentation of programming impact on the burden of malaria. The programming approaches required to implement SUFI are based on the public health planning, resourcing, implementation and evaluation cycle (the PRIME) and a core set of essential methodologies for malaria program scale-up. Zambia, Swaziland and Ethiopia have documented attaining program coverage of a consensus package of malaria interventions

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Scientifi c Session 138 2:15 p.m. 1008 American Committee of Molecular, Cellular and Immunoparasitology (ACMCIP): Immunoparasitology II VIVAX MALARIA VACCINE DEVELOPMENT: TAKING Supported with funding from the Burroughs Wellcome Fund CUES FROM NATURE Salon 3 Sope Olugbile1, Akihide Takagi Takagi1, Pu Liu1, Malcolm Gardner1, Ivan Dario Velez2, Ruobing Wang1 Saturday, November 21, 1:30 p.m. - 3:15 p.m. 1Seattle Biomedical Research Institute, Seattle, WA, United States, 2Programa de Estudio CHAIR y Control de Enfermedades Tropicales PECET. Universidad de Antioquia, Medellín, Joao Carlos Aguiar Colombia Naval Medical Research Center, Silver Spring, MD, United States 2:30 p.m. Ian A. Cockburn Johns Hopkins University, Baltimore, MD, United States 1009 1:30 p.m. DISCOVERING NOVEL PRE-ERYTHROCYTIC ANTIGENS 1152 FOR MALARIA VACCINES Joao Carlos Aguiar1, Jessica Bolton1, Joyce Wanga1, AnneMarie Urquhart2, DOMINANT CD8+ T CELL RESPONSES ARE ESSENTIAL John B. Sacci3, Keith Limbach1, Takafumi Tsuboi4, Chris Ockenhouse2, 1 FOR OPTIMAL CONTROL OF TRYPANOSOMA CRUZI Thomas L. Richie INFECTION 1Naval Medical Research Center, Silver Spring, MD, United States, 2Walter Reed Army Institute of Research, Silver Spring, MD, United States, 3The University of Maryland 1,2 1 3 Charles S. Rosenberg , Diana L. Martin , Rick L. Tarleton1 School of Medicine, Baltimore, MD, United States, 4Cell-Free Science and Technology 1The Center for Tropical and Emerging Global Diseases and the Departments of Research Center, Ehime University, Matsuyama, Japan 2Microbiology and 3Cellular Biology, University of Georgia, Athens, GA, United States 2:45 p.m. 1:45 p.m. 1010 1006 IL-2-PRODUCING EFFECTOR MEMORY AND CENTRAL PRESENTATION OF CD8+ EPITOPES IN THE MEMORY CD4+ T CELL SUBSETS ARE ASSOCIATED CIRCUMSPOROZOITE PROTEIN OF P. BERGHEI IS WITH PROTECTIVE IMMUNITY IN RTS,S-IMMUNIZED STRICTLY TAP DEPENDENT SUBJECTS Ian A. Cockburn1, Sze-Wah Tse1, Andrea J. Radtke1, Yun-Chi Chen1, Photini Joanne Lumsden1, Robert J. Schwenk1, Lisa Egner1, Joe Cohen2, Ripley Sinnis2, Fidel Zavala1 Ballou2, Opokua Ofori-Anyinam2, Philippe Moris2, Kent E. Kester1, D. Gray 1Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, Heppner1, Urszula Krzych1 Baltimore, MD, United States, 2Department of Medical Parasitology, New York 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2GSK University, New York, NY, United States Biologicals, Rixensart, Belgium 2 p.m. 3 p.m.

1007 1011

PROFILING ANTIBODY RESPONSES TO P. FALCIPARUM GENETICALLY ATTENUATED VACCINES INDUCE INFECTION BY PROTEIN MICROARRAY-A STRATEGY CONTACT-DEPENDENT CD8+ T CELL KILLING FOR IDENTIFYING NOVEL MALARIA VACCINE TARGETS OF PLASMODIUM YOELII LIVER STAGE-INFECTED Peter D. Crompton1, Matthew A. Kayala2, Boubacar Traore3, Kassoum HEPATOCYTES 3 3 1 4 Kayentao , Aissata Ongoiba , Greta E. Weiss , Douglas M. Molina , Chad Megha Gupta1, Adama Trimnell1, Akihide Takagi1, Thomas L. Richie2, Stefan 5 1 5 3 R. Burk , Michael Waisberg , Algis Jasinskas , Safi atou Doumbo , Didier H. Kappe1, Ruobing Wang1 Doumtabe3, Younoussou Kone3, David L. Narum6, Xiaowu Liang4, Ogobara 1 2 K. Doumbo3, Louis H. Miller6, Denise L. Doolan7, Pierre Baldi2, Philip L. Seattle Biomedical Research Institute, Seattle, WA, United States, Naval Medical Felgner5, Susan K. Pierce1 Research Center, Silver Spring, MD, United States 1Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, CHAIR 2 National Institutes of Health, Rockville, MD, United States, School of Information and Ian A. Cockburn Computer Sciences, Institute for Genomics and Bioinformatics, University of California, Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD, 3 Irvine, CA, United States, Malaria Research and Training Center, Faculty of Medicine, United States Pharmacy and Dentistry, University of Bamako, Bamako, Mali, 4Antigen Discovery, Inc., Irvine, CA, United States, 5Department of Medicine, Division of Infectious Diseases, University of California, Irvine, CA, United States, 6Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States, 7Molecular Vaccinology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia

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Scientifi c Session 139 2:30 p.m. 1016 Arthropods/Entomology Delaware A FEED-THROUGH CONTROL FOR LARVAL SAND FLIES Saturday, November 21, 1:30 p.m. - 3:15 p.m. USING HOST-TARGETED INSECTICIDE Gideon Wasserberg1, Richard Poche2, Larisa A. Polyakova2, Michelle V. CHAIR Chenault1, Gabriela Zollner1, Edgar D. Rowton1, David Miller2 Laura C. Harrington 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2Genesis Cornell University, Ithaca, NY, United States Laboratories, Inc., Wellington, CO, United States Michelle Helinski 2:45 p.m. Cornell University, Ithaca, NY, United States 1:30 p.m. 1017

1012 ASSORTATIVE MATING IN THE DENGUE VECTOR MOSQUITO, AEDES AEGYPTI INTERACTIONS BETWEEN MUTUALIST Laura C. Harrington, Katherine J. Connors, Lauren J. Cator, Michelle E. WIGGLESWORTHIA AND TSETSE PEPTIDOGLYCAN Helinski RECOGNITION PROTEIN (PGRP-LB) INFLUENCE Cornell University, Ithaca, NY, United States TRYPANOSOME TRANSMISSION 3 p.m. Jingwen Wang, Yineng Wu, Guangxiao Yang, Serap Aksoy Yale University, New Haven, CT, United States 1018 1:45 p.m. THE EFFECT OF MALE MATING HISTORY AND BODY 1013 SIZE ON FEMALE FECUNDITY AND LONGEVITY IN THE DENGUE VECTOR AEDES AEGYPTI THE MOSQUITO HEART: FUNCTIONAL MECHANICS Michelle E. Helinski, Laura Sirot, Mariana F. Wolfner, Laura C. Harrington AND ROLE IN MALARIA SPOROZOITE MIGRATION Cornell, Ithaca, NY, United States Julian F. Hillyer, Jonas G. King, Justin D. Glenn Vanderbilt University, Nashville, TN, United States Symposium 140 (ACMCIP Abstract) Emerging Arboviral Infections among International 2 p.m. Travelers 1014 Delaware B Saturday, November 21, 1:30 p.m. - 3:15 p.m. GENE DUPLICATION AND GENOME EVOLUTION IN THE IXODIDAE The geographic expansion of arboviral infections has also affected Janice Van Zee1, Jason Meyer1, Shannon Schlueter1, Jessica Schlueter1, Phil international travelers. International travelers have the potential both to Dixon2, Catherine Hill1 acquire and to spread these infections. The most rapidly emerging arboviral 1Purdue University, West Lafayette, IN, United States, 2Iowa State University, Ames, diseases in travelers are dengue and chikungunya. It is paramount that health IA, United States care providers have an understanding of the epidemiology and risk, clinical spectrum, diagnosis, management and prevention of these emerging diseases 2:15 p.m. in travelers.

1015 CHAIR Annelies Wilder-Smith EFFICIENCY AND RELIABILITY OF RBCL AND CRCL3 National University of Singapore, Singapore, Singapore IN MARKING TRIATOMA BRASILIENSIS NYMPHS: Duane Gubler PERSISTENCE AND INFLUENCE OF TRACE ELEMENTS Asia-Pacifi c Institute of Tropical Medicine and Infectious Disease, Honolulu, HI, United ON INSECT BIOLOGY States

Rafael M. Freitas, Otilia Sarquis, Livia S. Oliveira, Jailey M. Gonçalves, 1:30 p.m. Saturday, November 21 Reginalo L. Rego, Marli M. Lima Oswaldo Cruz Foundation, Rio de Janeiro, Brazil THE EVOLUTION OF THE GEOGRAPHIC EXPANSION OF ARBOVIRAL INFECTIONS Duane Gubler Asia-Pacifi c Institute of Tropical Medicine and Infectious Disease, Honolulu, HI, United States

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1:55 p.m. 2:50 p.m. DENGUE IN TRAVELERS EXTENDING A HAND: ELI LILLY’S TB DRUG DISCOVERY Eli Schwartz PARTNERSHIP Sheba Medical Center, Tel Hashomer, Israel Gail H. Cassell Eli Lilly & Co., Indianapolis, IN, United States 2:20 p.m. EPIDEMIOLOGY AND CLINICAL MANIFESTATIONS OF Symposium 142 CHIKUNGUNYA IN TRAVELERS Philippe Parola Managing Childhood Illness at Community Level: Good WHO Collaborating Centre for Rickettsioses and Arboviral Diseases, Marseille, France News from Africa 2:45 p.m. Virginia C PREVENTION OF DENGUE AND CHIKUNGUNYA IN Saturday, November 21, 1:30 p.m. - 3:15 p.m. TRAVELERS Community Case Management (CCM) is recognized today as a critical public Annelies Wilder-Smith health strategy to reach the fourth Millennium Development Goal, especially National University of Singapore, Singapore, Singapore in low- and middle-income countries. Malaria, pneumonia, diarrhea and neonatal infections contribute towards 76% of current mortality in children Symposium 141 under fi ve. Though there are effective interventions to prevent most of the deaths related to these conditions, they have failed to reach the children who Rummaging Through Pharma’s Attic: Taking Advantage of need them most. CCM is a strategy that delivers anti-malarials, antibiotics and a combination of oral rehydration therapy and zinc at the community level Industry’s Unused Assets to Generate New Products for by trained community health workers to the most vulnerable. The purpose of Infectious Diseases of the Developing World this symposium is to present recent evidence on CCM as part of a strategy to inform implementers, donors and policymakers and advocate for CCM scale- Virginia AB up. Saturday, November 21, 1:30 p.m. - 3:15 p.m. CHAIR Among members of the global health community, there is a keen interest Alexandra O. de Sousa in leveraging existing pharmaceutical assets to generate new medicines for UNICEF, New York, NY, United States infectious diseases of poverty, such as malaria, tuberculosis and kinetoplastid diseases. Access to the pharmaceutical and biotechnology industries’ Jennifer Bryce compound libraries, technology platforms and shelved products could expedite Johns Hopkins University, Baltimore, MD, United States product discovery and development, while simultaneously reducing the overall costs of innovation. But gaining access to industry’s assets requires more than 1:30 p.m. goodwill alone. In this session, leaders from industry, academia and non- ZAMBIA INTEGRATED MANAGEMENT OF MALARIA AND profi t product development partnerships (PDPs) will discuss strategies for PNEUMONIA harnessing industry resources for new product innovation. Kojo Yeboah-Antwi CHAIR Boston University, Boston, MA, United States Christopher D. Earl 1:55 p.m. BIO Ventures for Global Health, Washington, DC, United States LET’S TALK ABOUT SCALE: INTEGRATED COMMUNITY 1:30 p.m. CASE MANAGEMENT IN SIX COUNTRIES FINDING A DIAMOND IN THE ROUGH: SCREENING Emmanuel d’Harcourt INDUSTRY’S LIBRARIES AGAINST TROPICAL PARASITES International Rescue Committee, New York, NY, United States James H. McKerrow 2:20 p.m. University of California, San Francisco, San Francisco, CA, United States QUALITY OF CASE MANAGEMENT SERVICES FOR 1:55 p.m. PNEUMONIA, MALARIA AND DIARRHEA PROVIDED BY RAIDING THE DEEP FREEZE: THE FEXINIDAZOLE HEALTH SURVEILLANCE ASSISTANTS IN MALAWI STORY Cristina Cardemil Johns Hopkins School of Public Health, Baltimore, MD, United States Els Torreele Drugs for Neglected Diseases Initiative, Geneva, Switzerland 2:45 p.m. 2:20 p.m. AN INTEGRATED APPROACH FOR THE CASE WILL THEY RESPECT YOU IN THE MORNING: FORGING MANAGEMENT OF MALARIA AND PNEUMONIA AT PARTNERSHIPS WITH BIOTECH AND BIG PHARMA COMMUNITY LEVEL IN UGANDA James Tibenderana Jörg J. Möhrle Malaria Consortium, Kampala, Uganda Medicines for Malaria Venture, Geneva, Switzerland

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Symposium 143 Scientifi c Session 144

The Spatial Scale of Dengue Virus Transmission: Filariasis - Control Implications for Disease Prevention Washington 2 Washington 1 Saturday, November 21, 1:30 p.m. - 3:15 p.m. Saturday, November 21, 1:30 p.m. - 3:15 p.m. CHAIR Network models of infectious disease transmission predict that insight Paul T. Cantey into heterogeneity in the distribution and movement of infectious and Centers for Disease Control and Prevention, Atlanta, GA, United States susceptible individuals is fundamental to understanding and reducing Daniel J. Tisch pathogen transmission. Results from regional space-time studies have Case Western Reserve University, Cleveland, OH, United States revealed dengue transmission networks that are highly synchronized over hundreds of kilometers. In this symposium, we will examine the spatial 1:30 p.m. scale of dengue transmission dynamics and the implications for improving disease prevention. Participants, who are all engaged in spatially explicit 1019 dengue research, will discuss observed spatial scales of virus transmission patterns, core dynamics that defi ne the scale of transmission, scale-dependent DIAGNOSTIC TOOLS FOR LYMPHATIC FILARIASIS indicators of risk and how improved understanding of the spatial dimension of transmission will improve disease prevention. Virus transmission patterns ELIMINATION PROGRAM: RESULTS OF A COMMUNITY will be examined across scales ranging from clustering around households to AND SCHOOLCHILDREN SURVEY IN AN ISLAND OF citywide transmission networks to broad-scale dynamics across large endemic FRENCH POLYNESIA regions. Mechanisms for assessing and responding to risk at each scale will Catherine Plichart1, Lam Ngoc Nguyen1, Sylviane Teururai1, Clemence be reviewed. Emphasis will be on understanding the relationships between Gatti1, Herve Bossin1, Jerome Marie1, Marc Faaruia1, Albert Tetuanui1, transmission dynamics at each scale and patterns of epidemic disease, and the Tuterarii Paoaafaite1, Ralph Pawlowiez1, Sandra J. Laney2, Makoto Itoh3, role of spatial scale in developing resource-effi cient and cost-effective disease Anne-Marie Legrand1 prevention strategies. 1Institut Louis Malarde, Papeete-Tahiti, French Polynesia, 2Smith College, Northampon, MA, United States, 3Aichi Medical University, Aichi-ken, Japan CHAIR Karen M. Campbell 1:45 p.m. San Diego State University, San Diego, CA, United States 1020 Thomas W. Scott University of California, Davis, CA, United States INCREASED ADHERENCE TO MASS DRUG 1:30 p.m. ADMINISTRATION FOR LYMPHATIC FILARIASIS - LOCAL CLUSTERING OF DENGUE TRANSMISSION IN ORISSA STATE, INDIA, 2009 KAMPHAENG PHET, THAILAND Paul T. Cantey1, Grace Rao2, Jonathan Rout2, Anna Jolly1, John Williamson1, LeAnne Fox1 In-Kyu Yoon 1Division of Parasitic Diseases, NCZVED, Centers for Disease Control and Prevention, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand Atlanta, GA, United States, 2Church’s Auxiliary for Social Action, Bhubaneswar, India 1:55 p.m. 2 p.m. COMMUNITY-LEVEL DENGUE TRANSMISSION AND HUMAN MOVEMENT PATTERNS IN IQUITOS, PERU 1021 Amy C. Morrison University of California, Davis, Davis, CA, United States LONG LASTING INSECTICIDAL NETS ALONE CAN REDUCE TRANSMISSION OF LYMPHATIC FILARIASIS IN 2:20 p.m. SOUTHEAST NIGERIA FROM HOUSEHOLD TO COMMUNITY: INDICATORS Emmanuel Emukah1, Patricia M. Graves2, Aryc W. Mosher2, Lindsay OF RISK AND THE IMPLICATIONS FOR PREVENTION Rakers2, Emmanuel Miri3, Njoku Chidiebere1, Nwodu Kenrick1, Obiezu 1 1 2 STRATEGIES Josephine , Okpala T. Njideka , Frank O. Richards 1The Carter Center, Owerri, Nigeria, 2The Carter Center, Atlanta, GA, United States, Thomas W. Scott 3The Carter Center, Jos, Nigeria University of California, Davis, CA, United States

2:45 p.m. Saturday, November 21 FROM COMMUNITY TO PROVINCE TO REGION: SPACE-TIME VARIATION IN DENGUE TRANSMISSION NETWORKS AND INDICATORS OF RISK IN THAILAND Karen M. Campbell San Diego State University, San Diego, CA, United States

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2:15 p.m. 1:30 p.m.

1022 1025

TRANSMISSION INTENSITY AND BIOMARKERS OF POSSIBLE INTERRUPTION OF MALARIA TRANSMISSION WUCHERERIA BANCROFTI INFECTION 10 YEARS AFTER IN TWO HIGHLAND AREAS OF KENYA CESSATION OF MASS DRUG ADMINISTRATION TO Chandy C. John1, Melissa A. Riedesel1, Ng’wena G. Magak2, David M. ELIMINATE LYMPHATIC FILARIASIS IN PAPUA NEW Menge1, Kim A. Lindblade3, John M. Vulule4, James A. Hodges1, Willis GUINEA Akhwale5 1 2 1 1 1 2 University of Minnesota, Minneapolis, MN, United States, Moi University, Eldoret, Daniel J. Tisch , Will Kastens , Bockarie J. Moses , Moses Baisor , Melinda 3 4 2 2 2 2 3 Kenya, Centers for Disease Control and Prevention, Atlanta, GA, United States, Kenya Susapa , Daphne Sepe , Kay Baia , Manasseh Baia , John Reeder , Edwin Medical Research Institute, Kisumu, Kenya, 5Ministry of Health, Nairobi, Kenya Michael4, Peter Siba5, James W. Kazura1 1 2 Case Western Reserve University, Cleveland, OH, United States, Papua New Guinea 1:45 p.m. Institute of Medical Research, Madang, Papua New Guinea, 3Burnet Institute, Melbourne, Australia, 4Imperial College, London, United Kingdom, 5Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea 1026 2:30 p.m. PREVALENCE OF PCR-DETECTABLE PLASMODIUM PARASITEMIA IN PARTICIPANTS IN THE DEMOCRATIC 1023 REPUBLIC OF THE CONGO, 2007 DEMOGRAPHIC HEALTH SURVEY DOES TRANSMISSION TAKE PLACE IN HYPOENDEMIC Steve M. Taylor1, Jonathan J. Juliano2, Jeremie Muwonga3, Augustin AREAS FOR ONCHOCERCIASIS? A STUDY IN NORTH Okenge3, Antoinette Tshefu4, Janey Messina5, Ann A. Way6, Mohamed Ayad6, REGION OF CAMEROON Michael Emch5, Steven R. Meshnick1 1 1 2 2 Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, Moses N. Katabarwa , Albert Eyamba , Mouhamadou Souaibou , Peter 2 3 4 5 5 United States, Division of Infectious Diseases, University of North Carolina, Chapel Enyong , Thomas Kuete , Yaya Souleymanou , Abudoulaye Yougoude , 3 6 6 1 1 Hill, NC, United States, Programme National de Lutte Contre le Sida, Kinshasa, Gervais O. Andze , Marceline Ntep , Lindsay Rakers , Donald Hopkins , 4 1 The Democratic Republic of the Congo, Kinshasa School of Public Health, Kinshasa, Frank Richards 5 1Emory University/The Carter Center, Atlanta, GA, United States, 2The Carter Center, The Democratic Republic of the Congo, Department of Geography, University of North 6 Yaounde, Cameroon, 3Research Foundation for Tropical Disease and Environment, Carolina, Chapel Hill, NC, United States, Measure DHS, Calverton, MD, United Buea, Cameroon, 4University of Doula, Doula, Cameroon, 5Ministry of Health, Garoua, States Cameroon, 6Ministry of Health, Yaounde, Cameroon 2 p.m. 2:45 p.m. 1027 1024 DOES INDOOR RESIDUAL SPRAYING PROVIDE ADDED PROGRESS ON THE ELIMINATION OF PROTECTION TO INSECTICIDE TREATED NETS IN ONCHOCERCIASIS (RIVER BLINDNESS) FROM THE PREVENTING MALARIA - PRELIMINARY RESULTS OF AN AMERICAS INCIDENCE COHORT Frank O. Richards1, Mauricio Sauerbrey2, Guillermo Zea Flores2, Alfredo Mary J. Hamel1, Peter Otieno1, Nabie Bayoh1, Simon Kariuki1, Kayla Dominguez Vazquez2, Alba Lucia Morales2, Ed Cupp3 Laserson1, Willis Akhwale2, John Williamson3, Laurence Slutsker3, John 1Carter Center, Atlanta, GA, United States, 2Onchocerciasis Elimination Program for the Gimnig3 Americas, Guatemala City, Guatemala, 3Auburn University, Auburn, AL, United States 1Centers for Disease Control and Prevention/Kenya Medical Research Institute Research Station, Kisumu, Kenya, 2Kenya Ministry of Health, Nairobi, Kenya, 3Centers for Scientifi c Session 145 Disease Control and Prevention, Atlanta, GA, United States 2:15 p.m. Malaria - Epidemiology II 1028 Washington 3 Saturday, November 21, 1:30 p.m. - 3:15 p.m. THIRTY YEARS OF PLASMODIUM FALCIPARUM TRANSMISSION IN KENYA: TIME-SPACE MODELING OF CHAIR PARASITE PREVALENCE Chandy C. John 1 2 1 3 University of Minnesota, Minneapolis, MN, United States Abdisalan M. Noor , Peter W. Gething , Victor A. Alegana , Eric Muchiri , Robert W. Snow1 Giovanna Raso 1Kenya Medical Research Institute/Wellcome Trust/University of Oxford Collaborative Environment et Santé, Centre Suisse de Recherches Scientifi ques, Abidjan, Cote d’Ivoire Research Programme, Nairobi, Kenya, 2Spatial Ecology and Epidemiology Group, Tinbergen Building, Department of Zoology, University of Oxford, Oxford, United Kingdom, 3Division of Vector Borne and Neglected Disease, Ministry of Health, Nairobi, Kenya

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2:30 p.m. 1:30 p.m.

1029 1032

SPATIAL RISK PROFILING OF PLASMODIUM FALCIPARUM INDUCTION OF VACCINE-SPECIFIC T CELL AND PARASITEMIA IN WESTERN CÔTE D’IVOIRE ANTIBODY RESPONSES IN RHESUS MACAQUES Giovanna Raso1, Kigbafori D. Silué1, Penelope Vounatsou2, Burton H. IMMUNIZED WITH TWO P. VIVAX CIRCUMSPOROZOITE- Singer3, Marcel Tanner2, Juerg Utzinger2, Eliézer K. N’Goran4 BASED VACCINE ANTIGEN CANDIDATES FORMULATED 1Centre Suisse de Recherches Scientifi ques, Abidjan, Cote d’Ivoire, 2Swiss Tropical IN AS01 3 B Institute, Basel, Switzerland, Princeton University, Princeton, NJ, United States, 1 2 1 4University of Cocody-Abidjan, Abidjan, Cote d’Ivoire Yannick Vanloubbeeck , Sathit Pichyangkul , Babak Bayat , Kosol Yongvanitchit2, Utaiwan Srichairatanakul2, Amporn Chluaydumrong2, Marie- 1 1 1 3 2:45 p.m. Noelle Donner , Virginie Garze , Aram Afsar , Lisa Ware , Marie-Claude Dubois1, Pascal Mettens1, Laurence Lemiale4, Mark Polhemus3, Brent House3, Jetsumon Sattabongkot2, Kurt Schaecher3, Christian Ockenhouse3, Joe 1030 Cohen1, Anjali Yadava3 1GlaxoSmithKline Biologicals, Rixensart, Belgium, 2Armed Forces Research Institute of SUBMICROSCOPIC PLASMODIUM FALCIPARUM Medical Sciences, Bangkok, Thailand, 3Walter Reed Army Institute of Research, Silver INFECTION IN ENDEMIC POPULATION SURVEYS: A Spring, MD, United States, 4The PATH Malaria Vaccine Initiative, Bethesda, MD, SYSTEMATIC REVIEW AND META-ANALYSIS United States Lucy C. Okell1, Azra C. Ghani2, Emily Lyons2, Chris Drakeley1 1:45 p.m. 1London School of Hygiene and Tropical Medicine, London, United Kingdom, 2Imperial College London, London, United Kingdom 1033 3 p.m. EVALUATION OF A HETEROLOGOUS PRIME-BOOST 1031 VACCINE SCHEDULE BASED ON LOW SEROPREVALENT ADENOVIRUS VECTORS FOR MALARIA BIOLOGICAL AND CLINICAL IMMUNITY TO MALARIA Ariane Rodríguez Rodríguez, Gert Gillissen, Dennis Tax, Ratna Mintardjo, INCREASE WITH AGE IN KENYAN HIGHLAND AREAS Harmjan Kuipers, Jerome Custers, Maria Grazia Pau, Stefan Kostense, WITH UNSTABLE TRANSMISSION Jenny Hendriks, Mariska ter Haak, Jaap Goudsmit, Katarina Radošević Crucell, Leiden, The Netherlands Melissa A. Riedesel1, Matthew McCarra1, Ng’wena G. Magak2, Kacey C. Ernst3, Chandy C. John1 2 p.m. 1University of Minnesota, Minneapolis, MN, United States, 2Moi University, Eldoret, 3 Kenya, University of Arizona, Tucson, AZ, United States 1034 Scientifi c Session 146 A NON-ADJUVANTED POLYPEPTIDE NANOPARTICLE Malaria - Vaccines I VACCINE TARGETING PLASMODIUM FALCIPARUM CSP Washington 4 INDUCES 100% STERILE PROTECTION AGAINST LETHAL CHALLENGE WITH LIVE SPOROZOITES Saturday, November 21, 1:30 p.m. - 3:15 p.m. Stephen A. Kaba1, Clara Brando1, Christian Mittelholzer2, Qin Guo1, Ian CHAIR McWilliams1, Andrea Crisanti3, Roberta Spaccapelo4, Peter Burkhard5, David E. Lanar1 Sheetij Dutta 1Walter Reed Army Institute of Research, Silver Spring, MD, United States, 2M.E. Walter Reed Army Institute of Research, Silver Spring, MD, United States Muller Institute, Basel, Switzerland, 3Imperial College, London, United Kingdom, Vidadi M. Yusibov 4Universita degli Studi di Perugia, Perugia, Italy, 5University of Connecticut, Storrs, CT, Fraunhofer USA, Newark, DE, United States United States 2:15 p.m.

1035

IMAGING MURINE NALT FOLLOWING PROTECTIVE

INTRANASAL IMMUNIZATION WITH P. FALCIPARUM CS Saturday, November 21 PROTEIN CONJUGATED TO FLAGELLIN, A POTENT TLR5 AGONIST Adéla Nacer1, Daniel Carapau1, Robert Mitchell1, Alan Shaw2, Ute Frevert1, Elizabeth Nardin1 1New York University School of Medicine, New York, NY, United States, 2VaxInnate Corporation, Cranbury, NJ, United States (ACMCIP Abstract)

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2:30 p.m. 1:30 p.m.

1036 1039

FROM RODENTS TO HUMANS: DEVELOPMENT OF A HEMOGLOBIN AND RED BLOOD CELL P52KO BASED WHOLE ORGANISM MALARIA VACCINE POLYMORPHISMS THAT CONFER PROTECTION Ben C. Van Schaijk1, Martijn Vos1, Geert-Jan van Gemert1, Marga van de AGAINST SEVERE PLASMODIUM FALCIPARUM MALARIA Vegte-Bolmer1, Audrey Gego2, Samir Yalaoui2, Jean-Francois Franetich2, Ivo ARE EXCEEDINGLY COMMON IN MALI 1 2 3 3 Ploemen , Dominique Mazier , Chris J. Janse , Shahid M. Khan , Robert W. 1 2 1 1 Seidina A. S. Diakité , Michael A. Krause , Karim Traoré , Tatiana M. Sauerwein 2 1 1 2 1 2 Lopera-Mesa , Saibou Doumbia , Drissa Konaté , Maria Cecilia Huaman , Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, INSERM, 1 2 2 3 Mory Doumbia , Ababacar Diouf , Jennifer M. Anderson , Seydou Université Pierre et Marie Curie-Paris6, Paris, France, Leiden University Medical Doumbia1, Carole A. Long2, Rick M. Fairhurst2, Mahamadou Diakité1 Centre, Leiden, The Netherlands 1Malaria Research and Training Center, Bamako, Mali, 2Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National 3 p.m. Institutes of Health, Rockville, MD, United States 1037 1:45 p.m.

DESIGNING A PAN-REACTIVE MALARIA VACCINE 1040 BASED ON THE CROSS-REACTIVE EPITOPES OF APICAL MEMBRANE ANTIGEN-1 OF PLASMODIUM FALCIPARUM PRESUMPTIVE TREATMENT INCREASES RISK OF Sheetij Dutta1, Lisa Dlugosz1, Margaret Schwarz1, Joshua Clayton1, Michael INFLAMMATION AND POOR FETAL OUTCOMES IN Foley2, Robin Anders2, Adrian Batchelor1 WOMEN WITH PLACENTAL MALARIA AT DELIVERY 1 2 Walter Reed Army Institute of Research, Silver Spring, MD, United States, Department Whitney E. Harrington1, Edward Kabyemela1, Atis Muehlenbachs1, Kathryn of Biochemistry, La Trobe University, Australia Williamson1, Theonest K. Mutabingwa2, Michal Fried1, Patrick E. Duffy1 1Seattle Biomedical Research Institute, Seattle, WA, United States, 2National Institute of 3:15 p.m. Medical Research, Dar es Salaam, United Republic of Tanzania 1038 2 p.m.

ANTIBODIES TO PLANT-PRODUCED PLASMODIUM 1041 FALCIPARUM SEXUAL STAGE PROTEIN PFS25 EXHIBIT TRANSMISSION BLOCKING ACTIVITY RETINAL ANGIOGRAPHIC CHANGES IN PAEDIATRIC Vidadi Yusibov1, Jessica A. Chichester1, Christine E. Farrance1, Vadim CEREBRAL MALARIA Mett1, Konstantin Musiychuk1, Moneim Shamloul1, Satish Sharma1, Stephen Simon J. Glover1, Simon P. Harding2, Malcolm E. Molyneux3, Terrie E. Streatfi eld1, Natalia Ugulava1, Robert W. Sauerwein2, Will Roeffen2, Yimin Taylor4, Nicholas A. Beare5 Wu3, Olga Muratova3, Louis H. Miller3, Douglas A. Holtzman4 1College of Medicine, Blantyre, Malawi, 2University of Liverpool, Liverpool, United 1Fraunhofer USA, Center for Molecular Biotechnology, Newark, DE, United States, Kingdom, 3Malawi-Liverpool-Wellcome Trust/College of Medicine, Blantyre, Malawi, 2Radboud University Medical Centre, Nijmegen, The Netherlands, 3Malaria Vaccine 4Blantyre Malaria Project, Blantyre, Malawi, 5Royal Liverpool University Hospitals Development Branch, National Institute of Allergy and Infectious Diseases, National Trust, Liverpool, United Kingdom Institutes of Health, Rockville, MD, United States, 4The Bill and Melinda Gates Foundation, Seattle, WA, United States 2:15 p.m. (ACMCIP Abstract) 1042 Scientifi c Session 147 TRANSCRIPTIONAL PROFILE COMPARISON OF Malaria - Biology and Pathogenesis II HOST IMMUNE RESPONSE TO SEVERE VERSUS UNCOMPLICATED FALCIPARUM MALARIA: A CASE- Washington 5 CONTROL STUDY IN MALIAN CHILDREN Saturday, November 21, 1:30 p.m. - 3:15 p.m. Jessica E. Manning1, Amadou Niangaly1, Antoine Dara1, Abdoulaye K. 1 1 1 2 CHAIR Kone , Mahamadou A. Thera , Abdoulaye A. Djimde , Guy Vernet , Philippe Leissner3, Christopher Plowe4, Ogobara Doumbo1 Mahamadou Diakite 1Malaria Research and Training Center, University of Bamako, Bamako, Mali, University of Bamako, Bamako, Mali 2Fondation Merieux, Lyon, France, 3BioMerieux, Grenoble, France, 4Howard Hughes Whitney E. Harrington Medical Institute/Center for Vaccine Development, University of Maryland, Baltimore, SBRI, Seattle, WA, United States MD, United States

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2:30 p.m. 1:30 p.m. PATTERNS OF AND FACTORS IN HEALTHCARE 1043 PROVIDER MIGRATION DOWN-REGULATION OF ANTI-INFLAMMATORY Noreen A. Hynes Johns Hopkins University School of Medicine, Baltimore, MD, United States AND ANTI-APOPTOTIC GENE EXPRESSION DURING UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA 1:50 p.m. 1 2 3 Ousmane A. Koita , Joni H. Ylostalo , James M. Colborn , Ousmane H. STEMMING THE TIDE: IMPROVING HEALTH CARE Cisse1, Donald J. Krogstad4 1University of Bamako, Bamako, Mali, 2University of Texas, Temple, Temple, TX, PROVIDER TRAINING United States, 3Centers for Disease Control and Prevention, San Juan, PR, United Robert Bollinger States, 4Tulane University Health Sciences Center, New Orleans, LA, United States Johns Hopkins University School of Medicine, Baltimore, MD, United States (ACMCIP Abstract) 2:20 p.m. 2:45 p.m. STEMMING THE TIDE: INNOVATION AND 1044 EMPOWERMENT IN THE PUBLIC HEALTH-MEDICAL CARE INTERFACE DETECTION AND VALIDATION OF COMPLEMENT Joel Selanikio COMPONENT C3A AS A NOVEL BIOMARKER FOR Datadyne, Washington, DC, United States CEREBRAL MALARIA 2:50 p.m. Sarah J. Higgins, Karlee Silver, Shehzad Iqbal, Samir Patel, Kathleen Zhong, Andrea Conroy, Kevin C. Kain CAN WE STEM THE TIDE OF THE “BRAIN DRAIN”? McLaughlin-Rotman Centre for Global Health University of Toronto, Toronto, ON, Fitzhugh Mullan Canada George Washington University, Washington, DC, United States (ACMCIP Abstract) 3 p.m. Scientifi c Session 149

1045 Schistosomiasis and Other Trematodes - Epidemiology/ Control WHOLE BLOOD ANGIOPOIETIN-1 AND -2 LEVELS DISCRIMINATE CEREBRAL AND SEVERE MALARIA Salon 1 FROM UNCOMPLICATED MALARIA Saturday, November 21, 3:45 p.m. - 5:30 p.m. Andrea L. Conroy1, Erin I. Lafferty1, Fiona E. Lovegrove1, Srivicha CHAIR Krudsood2, Noppadon Tangpukdee2, Sornchai Looareesuwan2, W. Conrad Andrea Gazzinelli Liles3, Kevin C. Kain3 1McLauglin-Rotman Centre for Global Health, University of Toronto, Toronto, ON, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Canada, 2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Donald P. McManus 3Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, The Queensland Institute of Medical Research, Brisbane, Australia University of Toronto, Toronto, ON, Canada 3:45 p.m. Symposium 148 1046 Global Health Workforce Crises: Impact of International THE ROLE OF BOVINES IN HUMAN SCHISTOSOMA Migration JAPONICUM INFECTION IN THE PEOPLES’ REPUBLIC OF Wilson A CHINA 1 2 1 3 Saturday, November 21, 1:30 p.m. - 3:15 p.m. Darren J. Gray , Gail M. Williams , Yuesheng Li , Honggen Chen , Simon Forsyth2, Robert Li2, Adrian Barnett4, Jiagang Guo5, Allen Ross6, Zheng The international migration of health personnel poses a major challenge for Feng5, Donald P. McManus1 1 2 improving and maintaining health systems in developing countries. This Queensland Institute of Medical Research, Brisbane, Australia, University of 3 symposium will examine the migratory fl ow patterns, causes and impact Queensland, Brisbane, Australia, Jiangxi Provincial Institute of Parasitic Diseases, 4 5 of global south health care provider migration to the global north or more Nanchang, China, Queensland University of Technology, Brisbane, Australia, Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai, prosperous areas of the global south over the past 10-15 years. The scope Saturday, November 21 6 of the problem from the perspective of the receiving and source countries, China, Griffi th University, Brisbane, Australia including ethics and justice issues, will be examined. The World Health Organization’s recommendations for reversing these trends and proposed interventions to curb migration will be discussed.

CHAIR Noreen A. Hynes Johns Hopkins University School of Medicine, Baltimore, MD, United States Fitzhugh Mullan George Washington University, Washington, DC, United States

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4 p.m. 5:15 p.m.

1047 1052

EVIDENCE OF SYNERGISTIC EFFECTS BETWEEN RAPID ASSESSMENT OF SCHISTOSOMA HAEMATOBIUM PLASMODIUM SPP. AND SCHISTOSOMA HAEMATOBIUM INFECTION IN NIGER USING SCHOOL-BASED INFECTIONS ON ANEMIA AND STUNTING IN KENYAN QUESTIONNAIRES CHILDREN Anna E. Phillips1, Amadou Garba2, Aichatou Dijbo3, Joanne Webster1, Alfari Lia S. Florey1, Charles H. King2, Melissa K. Van Dyke1, Eric M. Muchiri3, Aichatou2, Ali Djibou2, Alan Fenwick1 Peter L. Mungai4, Peter A. Zimmerman2, Mark L. Wilson1 1Imperial College, London, United Kingdom, 2Schistosomiasis Control Initiative, 1University of Michigan, Ann Arbor, MI, United States, 2Case Western Reserve Niamey, Niger, 3Universite Abdou MouMouni, Niamey, Niger University, Cleveland, OH, United States, 3Division of Vector Borne and Neglected Diseases, Ministry of Public Health and Sanitation, Nairobi, Kenya, 4Msambweni Field Scientifi c Session 150 Station, Msambweni, Kenya 4:15 p.m. Malaria - Implementation of Malaria Control and Treatment Strategies 1048 Salon 2 THE IMPACT OF COMMUNITY CHARACTERISTICS ON Saturday, November 21, 3:45 p.m. - 5:30 p.m. INDIVIDUAL INFECTION RISK: NIGHT SOIL USE AND CHAIR SCHISTOSOMIASIS TRANSMISSION IN SOUTHWEST Justin M. Cohen CHINA Clinton Foundation HIV/AIDS Initiative, Brookline, MA, United States Elizabeth J. Carlton1, Edmund Y. Seto1, Bo Zhong2, Robert C. Spear1 Lisa Hare 1Department of Environmental Health Sciences, University of California, Berkeley, John Snow Inc., Arlington, VA, United States Berkeley, CA, United States, 2Institute for Parasitic Diseases, Sichuan Center for Disease Control and Prevention, Chengdu, China 3:45 p.m. 4:30 p.m. 1053 1049 GEOGRAPHIC VARIATION IN STOCKING AND SALES A SURVEY OF RODENTS FOR SCHISTOSOMES FROM OF SUBSIDIZED ARTEMISININ-BASED COMBINATION THE LAKE VICTORIA BASIN, KENYA, THE DISCOVERY THERAPIES BY PRIVATE DRUG SHOPS IN TWO RURAL OF A NEW SCHISTOSOME SPECIES, AND THE DISTRICTS OF TANZANIA IMPLICATIONS FOR SCHISTOSOMIASIS CONTROL Justin M. Cohen1, Kate Bowler1, Oliver Sabot1, Megumi Gordon1, Isaac 1 2 3 1 1 STRATEGIES Gross , David Bishop , Moses Odhiambo , Lorrayne Ward , Yahya Ipuge , Catherine Goodman4 1 1 1 2 Ben Hanelt , Sara V. Brant , Michelle L. Steinauer , Geoffrey M. Maina , 1Clinton HIV/AIDS Initiative, Boston, MA, United States, 2Mott MacDonald Ltd, 2 2 2 2 Joseph M. Kinuthia , Eric L. Agola , Ibrahim N. Mwangi , Ben N. Mungai , Birmingham, United Kingdom, 3The Steadman Group, Nairobi, Kenya, 4Kenyan 2 1 2 Martin W. Mutuku , Eric S. Loker , Gerald M. Mkoji Medical Research Institute/Wellcome Trust Research Programme, Nairobi, Kenya 1University of New Mexico, Albuquerque, NM, United States, 2Centre for Biotechnology Research and Development, KEMRI, Nairobi, Kenya 4 p.m.

4:45 p.m. 1054 1050 RAPID UPTAKE OF ARTEMISININ-BASED COMBINATION THERAPY IN RUFIJI DISTRICT, TANZANIA KHAT, SNAILS AND FLUKES: CLINICAL AND 1 2 3 EPIDEMIOLOGICAL FEATURES OF FASCIOLIASIS, AN Julie I. Thwing , Joseph D. Njau , Catherine A. Goodman , S. Patrick Kachur1, Elizeus Kahigwa2, Salim Abdullah2 EMERGING DISEASE IN THE UK 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Ifakara Joanna S. Herman, Meera A. Chand, Peter L. Chiodini Health Institute, Dar es Salaam, United Republic of Tanzania, 3KEMRI/Wellcome Hospital for Tropical Diseases, London, United Kingdom Trust, Nairobi, Kenya 5 p.m. 4:15 p.m.

1051 1055

ACCESSIBILITY AND UTILIZATION OF SAVING LIVES THROUGH INCREASED ACCESS TO SCHISTOSOMIASIS-RELATED HEALTH SERVICES IN ARTEMESIN-BASED COMBINATION THERAPY (ACT): A RURAL AREA IN NORTHERN MINAS GERAIS STATE, THE EXPERIENCE IN MALAWI BRAZIL Lisa Hare, Jayne Waweru, Elias Mwalabu, Evance Moyo, Ralph H. Rack Dener C. Reis1, Helmut Kloos2, Charles King3, Humberto F. Quites1, John Snow Inc., Arlington, VA, United States Leonardo F. Matoso1, Andrea Gazzinelli1 1Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, 2University California San Francisco, San Francisco, CA, United States, 3Case Western University, Cleveland, OH, United States

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4:30 p.m. Symposium 151 1056 One World One Health and Intercontinental Invaders THE COST OF SCALING UP INTERMITTENT PREVENTIVE Salon 3 TREATMENT IN INFANTS IN AFRICA Saturday, November 21, 3:45 p.m. - 5:30 p.m. Alexandra De Sousa UNICEF, New York, NY, United States This symposium will promote the concepts of the One Health Initiative (OHI). The OHI a movement to forge co-equal, all-inclusive collaborations 4:45 p.m. between physicians, veterinarians and other scientifi c-health related disciplines to improve human and animal health. Topics include water-borne infections 1057 of humans and animals, use of marine animals for surveillance of emerging infections, Rift Valley fever ecology/epidemiology, West Nile ecology and PRE-REFERRAL RECTAL ARTESUNATE IS COST- West Nile vaccine development for humans and equids. EFFECTIVE FOR TREATING SEVERE CHILDHOOD Co-Organized by the Society of Tropical Veterinary Medicine MALARIA Yesim Tozan1, Rajashree Panicker2, Sarah R. Darley2, Ramanan CHAIR 2 3 Laxminarayan , Joel G. Breman Bob H. Bokma 1 2 Boston University School of Public Health, Boston, MA, United States, Resources for United States Department of Agriculture, Riverdale, MD, United States the Future, Washington, DC, United States, 3Fogarty International Center, National Institutes of Health, Washington, DC, United States E. Paul Gibbs University of Florida, Gainesville, FL, United States 5 p.m. Thomas P. Monath Kleiner Perkins Caufi eld & Byers, Harvard, MA, United States 1058 3:45 p.m. IDENTIFYING THE OPTIMAL ANTI-MALARIA PROGRAM “ONE HEALTH” APPROACH TO INVESTIGATE FOR A COMMUNITY: THE NEED TO FOCUS ON SOCIAL ZOONOTIC WATERBORNE PROTOZOAL PARASITES IN WELFARE AS THE TARGET OUTCOME CALIFORNIA AND TANZANIA Derek W. Willis, Jeffrey S. Hammer Patricia A. Conrad Princeton University, Princeton, NJ, United States University of California at Davis, Davis, CA, United States 5:15 p.m. 4:05 p.m. 1059 RIFT VALLEY FEVER VIRUS, A ZOONOTIC DISEASE OF HIGH CONSEQUENCE IN BOTH THE VETERINARY AND HOW TO ENSURE PLASMODIUM FALCIPARUM HUMAN HEALTH ARENAS CHEMOSENSITIVITY RESULTS IN THE FIELD? Thomas G. Ksiazek University of Texas Medical Branch, Galveston, TX, United States Daniel Parzy1, Le Hong Quang2, Nguyen Xuan Thanh3, Marc Desbordes1, 4 Véronique Sinou 4:25 p.m. 1IMTSSA - UMR-MD3, Marseille, France, 2Military Center of Preventive Medicine, Ho Chi Minh City, Vietnam, 3Military Institute of Hygiene and Epidemiology, Hanoi, MARINE VERTEBRATES AS SENTINELS OF EMERGING Vietnam, 4Université de la Méditerranée - UMR-MD3, Marseille, France INFECTIOUS DISEASES: ECOLOGICAL HEALTH LINKING LAND TO SEA Alonso Aguirre Wildlife Trust, New York, NY, United States 4:45 p.m. HOW WEST NILE AND AVIAN INFLUENZA VIRUSES ILLUSTRATE THE CHALLENGES IN APPLYING ONE HEALTH Samantha E. Gibbs United States Fish and Wildlife Service, Arlington, VA, United States Saturday, November 21 5:05 p.m. CONCURRENT DEVELOPMENT OF NOVEL WEST NILE VACCINES FOR HUMANS AND EQUIDS: APPLICATION OF ONE HEALTH PRINCIPLES Thomas P. Monath Kleiner Perkins Caufi eld & Byers, Menlo Park, CA, United States

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Symposium 152 Symposium 153

New Trends in Anopheles darlingi: Divergence, Genetics, A Current Summary of Selected Zoonotic Diseases of Malaria Transmission and Ecology People and Their Pets Delaware A Delaware B Saturday, November 21, 3:45 p.m. - 5:30 p.m. Saturday, November 21, 3:45 p.m. - 5:30 p.m.

This session will review new evidence for lineage divergence in the Anopheles A series of presentations on diseases of human and veterinary health darlingi (Diptera: Culicidae), the most important and anthropophilic malaria importance will examine the zoonotic aspects of the parasitic or vector-borne vector in the Americas. Evolutionary forces shaping the genetic structure of agents, with an emphasis on new or noteworthy fi ndings. The focus of the An. darlingi across its extensive distribution from southern Mexico to northern symposium will be humans and their companion animals, dog and cats, within Argentina will be examined, as well as the putative impact of distinctive lineages the United States. Relevant details of clinical signs and symptoms, diagnosis on vectorial capacity and malaria transmission. The session will compare the and treatment will be reviewed for both human and veterinary patients, and complete mitochondrial genome of the putative An. darlingi lineages with An. opportunities and challenges for future research will be discussed. Talks gambiae, Aedes aegypti, Ae. albopictus and Drosophila yakuba, focusing on protein will discuss soil, water, and vector-borne diseases. The soil and water- coding genes, initial codons, stop codons and codon usage for amino acids, to borne presentations will cover giardiasis, cryptosporidiosis, toxoplasmosis, better understand the evolution of An. darlingi and its phylogenetic relationship toxocariasis, baylisascariasis and cutaneous larva migrans. The vector-borne to other genera of mosquitoes and to Diptera. In the Peruvian Amazon, a presentations will cover tick transmitted Lyme borreliosis, anaplasmosis, region of low intensity malaria transmission, asymptomatic humans appear to ehrlichiosis, and Rocky Mountain spotted fever, fl ea-associated bartonellosis, be reservoirs for Plasmodium vivax. This session will provide information on the typhus, and plague and mosquito-transmitted dirofi lariasis. clinical characteristics of symptomatic versus asymptomatic patients, methods to determine transmission patterns in experimental infection of natural (outbred) An. CHAIR darlingi and other malaria vectors and implications of such studies for transmission- Dwight D. Bowman blocking vaccines. The symposium will review a series of ecological investigations Cornell University, Ithaca, NY, United States of An. darlingi in Belize that have evaluated fl ight behavior using mark-release- recapture methods, detected bimodal biting patterns, assessed seasonal densities, Mark Eberhard Centers for Disease Control and Prevention, Atlanta, GA, United States discovered that the preferred breeding habitat of this species is fl oating detritus patches in rivers, used GIS and remote sensing to attempt to predict positive Ellen Carlin breeding sites and used reciprocal placement experiments to discover that An. Companion Animal Parasite Council, Washington, DC, United States darlingi survives best in its own habitat, compared with other local vectors. The Susan Montgomery session will focus on ways to use such information for novel control strategies. Centers for Disease Control and Prevention, Atlanta, GA, United States

CHAIR 3:45 p.m. Jan E. Conn PUBLIC HEALTH SIGNIFICANCE OF GIARDIASIS AND New York State Department of Health, Albany, NY, United States CRYPTOSPORIDIOSIS IN COMPANION ANIMALS Joseph M. Vinetz Vitaliano A. Cama University of California at San Diego, La Jolla, CA, United States Centers for Disease Control and Prevention, Atlanta, GA, United States 3:45 p.m. 3:55 p.m. EVIDENCE FOR LINEAGE DIVERGENCE IN ANOPHELES TOXOPLASMA GONDII: SUMMARIZING PREVALENCE AND DARLINGI RISK FACTORS Jan E. Conn Sharon Patton New York State Department of Health, Albany, NY, United States University of Tennessee, Knoxville, TN, United States 4:15 p.m. 4:10 p.m. THE MITOCHONDRIAL DNA OF ANOPHELES DARLINGI: CURRENT STATE OF TOXOCARA SPP. IN DOGS AND CATS: AN INSIGHT INTO EVOLUTION OF ANOPHELINE NEW INFORMATION ON TRANSMISSION, INFECTION MOSQUITOES AND ZOONOSIS Osvaldo Marinotti Anne M. Zajac University of California Irvine, Irvine, CA, United States Virginia Tech, Blacksburg, VA, United States 4:40 p.m. 4:20 p.m. HUMAN RESERVOIRS OF PLASMODIUM VIVAX HOOKWORMS AS AGENTS OF CUTANEOUS LARVA TRANSMISSION IN THE PERUVIAN AMAZON MIGRANS Joseph M. Vinetz Dwight D. Bowman University of California at San Diego, La Jolla, CA, United States Cornell University, Ithaca, NY, United States 5:05 p.m. 4:35 p.m. THE ECOLOGY OF ANOPHELES DARLINGI IN BELIZE AND AN UPDATE ON COMMON TICK-BORNE DISEASES THE ASSOCIATION WITH NOVEL VECTOR CONTROL SHARED BY DOGS AND PEOPLE, PART I: LYME STRATEGIES BORRELIOSIS Nicole Achee Susan E. Little Uniformed Services University of the Health Sciences, Bethesda, MD, United States Oklahoma State University, Stillwater, OK, United States

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4:45 p.m. 4:15 p.m. AN UPDATE ON COMMON TICK-BORNE DISEASES 1062 SHARED BY DOGS AND PEOPLE, PART II: RICKETTSIAL PATHOGENS A COMPARISON OF WATER TREATMENT PRACTICES William L. Nicholson AMONG PEOPLE LIVING WITH HIV/AIDS AND Centers for Disease Control and Prevention, Atlanta, GA, United States COMMUNITY MEMBERS IN ETHIOPIA, DECEMBER, 2008 5 p.m. Achuyt Bhattarai1, Ciara E. O’Reilly1, Sisay Alemayehu Abayneh2, Ribka Fantu2, Alemayehu Mekonnen2, Jelaludin Ahmed2, Beniam Feleke2, Rob CURRENT UNDERSTANDING OF FLEA-ASSOCIATED Quick1 ZOONOTIC DISEASES OF CATS: BARTONELLOSIS, 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Centers for TYPHUS, AND PLAGUE Disease Control and Prevention, Addis Ababa, Ethiopia Jennifer H. McQuiston Centers for Disease Control and Prevention, Atlanta, GA, United States 4:30 p.m. 5:15 p.m. 1063 CURRENT STATE OF DIROFILARIA IMMITIS IN THE U.S.: RANDOMIZED CONTROLLED TRIALS OF A PLASTIC NATIONAL SURVEY ON PREVALENCE OF HEARTWORM HOUSING BIOSAND FILTER IN CAMBODIA, GHANA AND INFECTION IN DOGS HONDURAS Mark L. Eberhard Christine E. Stauber1, Anna M. Fabiszewski2, Erin L. Printy2, Byron C. Centers for Disease Control and Prevention, Atlanta, GA, United States Kominek2, Adam R. Walters2, Kaida-may R. Liang2, Mark D. Sobsey2 1Georgia State University, Atlanta, GA, United States, 2University of North Carolina, Scientifi c Session 154 Chapel Hill, NC, United States

Water, Sanitation and Hygiene 4:45 p.m. Virginia AB 1064 Saturday, November 21, 3:45 p.m. - 5:30 p.m. A RETROFIT TO UPGRADE LOW-COST CERAMIC WATER CHAIR FILTER DEVICES TO PURIFIER STATUS Tarique M. Huda Jeffrey F. Williams, Michael A. Bridges, Duane D. Dunk, Lori Trimpe, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh Nevada Reuhlen, Jose I. Santiago Clair Null HaloSource Incorporated, Bothell, WA, United States Emory University, Atlanta, GA, United States 5 p.m. 3:45 p.m. 1065 1060 HOUSEHOLD PREDICTORS OF ABUNDANCE OF THE HOW TO GET SAFE WATER: PERSUASION, PEERS, LASSA VIRUS RESERVOIR, MASTOMYS NATALENSIS, IN PRICE, PROMOTERS OR PRODUCT? THE EASTERN PROVINCE OF SIERRA LEONE Clair Null1, Michael Kremer2, Edward Miguel3, Sendhil Mullainathan2, Alix Lina M. Moses1, Kandeh Kargbo2, James Koninga2, Willie Robert2, Victor K. Zwane4 Lungay2, Richard Fonnie2, Lansana D. Kanneh2, James J. Bangura3, Robert 1Rollins School of Public Health, Emory University, Atlanta, GA, United States, F. Garry1, Daniel G. Bausch1 2Harvard University, Cambridge, MA, United States, 3University of California, Berkeley, 1Tulane University, New Orleans, LA, United States, 2Kenema Government Hospital, CA, United States, 4The Bill and Melinda Gates Foundation, Seattle, WA, United States Kenema, Sierra Leone, 3Ministry of Health and Sanitation, Kenema Government Hospital, Kenema, Sierra Leone 4 p.m.

1061

INTERIM ASSESSMENT OF A SANITATION, HYGIENE EDUCATION AND WATER SUPPLY INTERVENTION IN RURAL BANGLADESH, 2008 Saturday, November 21 Tarique M. Huda1, Leanne Unicomb1, Richard B. Johnston2, Carole Tronchet2, Amal K. Halder1, Stephen P. Luby1 1International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, 2United Nations Children’s Fund (UNICEF), Dhaka, Bangladesh

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Symposium 155 Symposium 156

International Programmatic Experience in Lymphedema Lessons from 15 Years of Prospective Studies of Acute Management for Lymphatic Filariasis Dengue Illness Virginia C Washington 1 Saturday, November 21, 3:45 p.m. - 5:30 p.m. Saturday, November 21, 3:45 p.m. - 5:30 p.m.

Lymphatic Filariasis (LF) affects more than 120 million people in 81 countries With over 40 years of experience in the management of children with worldwide; over 40 million of whom suffer from LF-related disability, dengue, the Dengue Unit of the Queen Sirikit National Institute of Child including lymphedema, elephantiasis and hydrocele. The WHO Global Health (QSNICH) in Bangkok, Thailand, has been designated as a World Program to Eliminate Lymphatic Filariasis (GPELF), which began in 1998, Health Organization Collaborating Centre for Case Management of Dengue has two objectives: interruption of LF transmission and management of Hemorrhagic Fever/Dengue Shock Syndrome. Since 1994, QSNICH LF-related disability. As LF is ranked the second leading cause of disability physicians have been collaborating with investigators at the U.S. Armed worldwide and the social, physical, economic and psychological consequences Forces Research Institute of Medical Sciences (AFRIMS) and the University of LF-related disability are signifi cant, effective LF morbidity management of Massachusetts Medical School (UMMS) to conduct prospective studies of programs are critically needed. Effective morbidity management/disability children presenting within the fi rst 72 hours of suspected acute dengue illness. prevention programs reinforce community acceptance of mass drug Concurrent fi eld studies have been implemented by Armed Forces Research administration (MDA), and as such are important components of national LF Institute of the Medical Sciences, UMMS and Thai Ministry of Public Health elimination programs. This symposium will review programmatic experience investigators to identify host, vector and environmental factors that impact with lymphedema management programs for lymphatic fi lariasis from several dengue disease severity. These pivotal studies, supported by National Institute different countries, including East and West Africa and South Asia. It will also of Allergy and Infectious Diseases and USAMRMC, have yielded a detailed explore the role of non-governmental development organizations (NGDOs) and integrated picture of the clinical, virological, and immunological aspects engaged in disability-prevention efforts, discuss the integration of LF-related of human dengue virus infection. Participating investigators will review disability prevention efforts with other chronic disease prevention efforts, and both published and unpublished fi ndings from 15 years of study and discuss explore the challenges and future directions for LF morbidity management questions still to be addressed in dengue clinical research. programs worldwide. CHAIR CHAIR Stephen J. Thomas LeAnne M. Fox Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand Centers for Disease Control and Prevention, Atlanta, GA, United States Timothy P. Endy Els Mathieu State University of New York, Upstate Medical University, Syracuse, NY, United States Centers for Disease Control and Prevention, Atlanta, GA, United States 3:45 p.m. 3:45 p.m. CLINICAL DIAGNOSIS AND MANAGEMENT OF SEVERE THE GLOBAL CHALLENGE OF LYMPHEDEMA IN THE DENGUE DEVELOPING WORLD Siripen Kalayanarooj Pierre Brantus Queen Sirikit National Institute of Child Health, Bangkok, Thailand Handicap International, Prevessin-Moens, France 4:10 p.m. 4:10 p.m. CLINICAL AND MOLECULAR EPIDEMIOLOGY OF THE TOGO LYMPHEDEMA MANAGEMENT MODEL DENGUE IN A RURAL THAI COMMUNITY Ameyo Dorkenoo In-Kyu Yoon Ministry of Health, Lome, Togo Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand 4:35 p.m. 4:25 p.m. COMMUNITY-BASED LYMPHEDEMA MANAGEMENT IMMUNOLOGIC AND VIROLOGIC MARKERS OF IN ORISSA STATE, INDIA: A ROLE FOR COMMUNITY- DENGUE DISEASE SEVERITY BASED NGDOS Anon Srikiatkhachorn Jonathan Rout University of Massachusetts Medical School, Worcester, MA, United States Church’s Auxiliary for Social Action (CASA), New Delhi, India 4:45 p.m. 5 p.m. INTEGRATING CLINICAL AND LABORATORY DATA TO LYMPHEDEMA MANAGEMENT AND THE ROLE OF MASS PREDICT THE OUTCOME OF ACUTE DENGUE ILLNESS DRUG ADMINISTRATION: PATIENT PERSPECTIVES Sharone Green FROM TANZANIA University of Massachusetts Medical School, Worcester, MA, United States Charles D. Mackenzie Michigan State University, East Lansing, MI, United States

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Symposium 157 Symposium 158

New Techniques for Monitoring and Evaluating the Impact Malaria RDTs: Bench Performance Comparisons and Some of Insecticide Resistance in Mosquitoes Specifi c Issues Washington 2 Washington 3 Saturday, November 21, 3:45 p.m. - 5:30 p.m. Saturday, November 21, 3:45 p.m. - 5:30 p.m.

Insecticide resistance is increasing at a dramatic rate in malaria and dengue Malaria control and elimination is back to the global health agenda. Malaria vectors. New tools are being developed to detect this resistance, but there RDTs play an important role in diagnosis and case management, and their is an urgent need for measures to assess the impact of different resistance use is rapidly expanding globally. Many RDTs are now commercially mechanisms on the effi cacy of disease control. available and their performance is being compared head-to-head by the WHO-FIND malaria diagnostics evaluation program. Round one testing of CHAIR 41 products from 21 manufacturers is complete. The procedures and results Janet Hemingway will be presented. Besides quality, the selection of RDTs should also include Liverpool School of Tropical Medicine, Liverpool, United Kingdom geographical considerations. 3:45 p.m. CHAIR DEVELOPMENT OF MOLECULAR METHODS FOR Qin Cheng Australian Army Malaria Institute, Brisbane, Australia VECTOR POPULATION MONITORING David Bell Martin Donnelly Foundation for Innovative New Diagnostics, Geneva, Switzerland Liverpool School of Tropical Medicine, Liverpool, United Kingdom 3:45 p.m. 4:10 p.m. OPENING REMARKS FIELD USE OF MOLECULAR ASSAYS FOR RESISTANCE MONITORING IN AEDES David Bell WHO/FIND, Geneva, Switzerland Bill Black Colorado State University, Fort Collins, CO, United States 3:55 p.m. 4:35 p.m. CHARACTERIZATION AND SELECTION OF MALARIA SAMPLES FOR EVALUATION OF RDTS MONITORING OF INSECTICIDE RESISTANCE DATA IN A DENGUE DECISION SUPPORT SYSTEM Peter L. Chiodini Hospital for Tropical Diseases, London, United Kingdom Saul Lozano-Fuentes Colorado State University, Fort Collins, CO, United States 4:15 p.m. 5 p.m. METHODS FOR AND OBSERVATIONS FROM THE BENCH EVALUATION OF MALARIA RDTS NEW DEVELOPMENTS IN MALARIA DECISION SUPPORT SYSTEMS John W. Barnwell Centers for Disease Control and Prevention, Atlanta, United States Michael Coleman Liverpool School of Tropical Medicine, Liverpool, United Kingdom 4:35 p.m. ANALYSING THE BENCH PERFORMANCE OF RDTS Michelle L. Gatton Queensland Institute of Medical Research, Brisbane, Australia 4:55 p.m. SELECTION OF MALARIA RDTS IN SOUTH AMERICA Dionicia Gamboa Institute of Tropical Medicine “Alexander Von Humboldt”, Lima, Peru 4:55 p.m. SELECTION OF MALARIA RDTS IN SOUTH AMERICA Saturday, November 21 Qin Cheng Australian Army Malaria Institute, Brisbane, Australia 5:20 p.m. DISCUSSION

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Scientifi c Session 159 4:30 p.m. 1069 Malaria - Development and Functional Assessment of Antibodies to Malaria Antigens PFEMP1 IS THE MAJOR TARGET OF ANTIBODIES Washington 4 TO THE SURFACE OF P. FALCIPARUM-INFECTED Saturday, November 21, 3:45 p.m. - 5:30 p.m. ERYTHROCYTES THAT ARE ASSOCIATED WITH PROTECTION FROM MALARIA CHAIR Katherine Howell1, Joanne M. Chesson1, Linda Reiling1, Peter C. Bull2, Bryan Greenhouse George Warimwe2, Alan F. Cowman1, Kevin Marsh2, James G. Beeson1 University of California, San Francisco, San Francisco, CA, United States 1Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, 2Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi , Kenya Linda Reiling (ACMCIP Abstract) The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia 4:45 p.m. 3:45 p.m. 1070 1066 IMPACT OF INTERMITTENT PREVENTIVE TREATMENT ANTIMALARIAL ANTIBODIES ARE GOOD MARKERS OF WITH SULFADOXINE-PYRIMETHAMINE ON IMMUNE PRIOR EXPOSURE BUT NOT PROTECTION AGAINST RESPONSES TO ERYTHROCYTIC STAGE ANTIGENS IN SUBSEQUENT MALARIA IN CHILDREN IN KAMPALA, MOZAMBICAN CHILDREN UGANDA Diana Quelhas1, Laura Puyol2, Llorenc Quinto2, Tacilta Nhampossa1, Eusebio Bryan Greenhouse1, Benjamin Ho2, Moses R. Kamya3, Tamara D. Clark1, Macete1, Pedro Aide1, Elisa Serra-Casas2, Alfons Jimenez2, Pau Cistero2, Denise Njama-Meya3, Bridget Nzarubara3, Catherine Maiteki-Sebuguzi3, Alfredo Mayor2, Inacio Mandomando1, Sergi Sanz2, John Aponte2, Virander Sarah G. Staedke4, Philip J. Rosenthal1, Grant Dorsey1, Chandy C. John2 Chauhan3, Chetan Chitnis3, Pedro Alonso2, Clara Menendez2, Carlota 1University of California, San Francisco, San Francisco, CA, United States, 2University Dobano2 of Minnesota, Minneapolis, MN, United States, 3Makerere University, Kampala, 1Manhica Health Research Centre, Manhica, Mozambique, 2Centre de Recerca en Uganda, 4London School of Hygiene and Tropical Medicine, London, United Kingdom Salut Internacional de Barcelona, Barcelona, Spain, 3International Centre for Genetic 4 p.m. Engineering and Biotechnology, New Delhi, India 5 p.m. 1067 1071 ANALYSIS OF THE BIOLOGICAL FUNCTION OF ANTIBODIES ELICITED FOLLOWING IMMUNIZATION ACQUISITION OF ANTIBODIES TO THE PFRH2 OF MALARIA- NAÏVE SUBJECTS WITH A PLASMODIUM INVASION LIGANDS OF P. FALCIPARUM AND THEIR FALCIPARUM ERYTHROCYTE-BINDING ANTIGEN 175 ASSOCIATION WITH PROTECTION FROM MALARIA (EBA175) VACCINE Linda Reiling1, Jack S. Richards1, Tony Triglia1, Watcharee Chokejindachai2, Samuel E. Moretz1, Ababacar Diouf1, Hong Zhou1, Gregory Tullo1, Hanaa El John E. Donelson3, Elijah Dabod4, Pascal Michon4, Livingstone Tavul4, Alan Sahli2, Wendy Keitel2, Carole A. Long1 F. Cowman1, Ivo Mueller4, James G. Beeson1 1Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious 1The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, 2Mahidol Diseases, National Institutes of Health, Rockville, MD, United States, 2Baylor College of University, Bangkok, Thailand, 3University of Iowa, City of Iowa, IA, United States, Medicine, Houston, TX, United States 4Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea 4:15 p.m. 5:15 p.m.

1068 1072

DIFFERENT T EPITOPE REGIONS OF THE P. IDENTIFYING B-CELL EPITOPES WITHIN THE LIGAND FALCIPARUM MSP1-33 CRITICALLY INFLUENCED THE DOMAIN OF PLASMODIUM VIVAX DUFFY BINDING RESPONSIVENESS, MAGNITUDE, AND QUALITY OF PROTEIN ANTI-MSP1-19 ANTIBODIES Francis B. Ntumngia Kae Pusic1, Charmaine Aniya2, Susannah Lee1, Mazie Tsang1, James Senda2, University of South Florida, Tampa, FL, United States David Clements2, George Hui1 (ACMCIP Abstract) 1University of Hawaii, Honolulu, HI, United States, 2Hawaii Biotech Inc, Aiea, HI, United States

212 ASTMH 58th Annual Meeting www.astmh.org

Symposium 160 Symposium 160A

Vivax Malaria Research Late-Breaking Findings from a Recently Completed Trial of a Rotavirus Vaccine in Five Countries in Africa and Asia: Washington 5 Public Health Implications Saturday, November 21, 3:45 p.m. - 5:30 p.m. Wilson A Presentations will highlight important aspects of vivax malaria epidemiology, pathogenesis, drug resistance and host interactions. Saturday, November 21, 3:45 p.m. – 5:30 p.m. Rotavirus is a major cause of severe diarrhea and mortality in infants and CHAIR toddlers in the developing world. While rotavirus vaccines are used routinely John Adams in infants in the United States and a variety of other countries, they are not University of South Florida, Tampa, FL, United States yet utilized for children at highest risk for severe disease and mortality in Deirdre A. Joy Asia and Africa. This session will summarize fi ndings of a recently completed National Institute of Allergy and Infectious Diseases, National Institutes of Health, randomized, double-blind, placebo controlled investigation of effi cacy, Rockville, MD, United States immunogenicity and safety of an oral pentavalent rotavirus vaccine in two countries in Asia (Vietnam and Bangladesh) and three countries in Africa 3:45 p.m. (Ghana, Kenya and Mali). The trial which began in 2007, concluded in March 2009. In addition to the key fi ndings of this trial, the session will review MICROSATELLITE DIVERSITY IN PLASMODIUM VIVAX information on rotavirus burden of disease, impact of introduction of rotavirus FIELD PARASITE ISOLATES vaccines in other parts of the world, and will put these fi ndings in context with Nadira D. Karunaweera other trials and post-marketing assessments to consider the way forward for University of Colombo, Colombo, Sri Lanka reducing the disease burden from diarrheal disease due to rotavirus.

4:05 p.m. CHAIR MOLECULAR ANALYSES OF PLASMODIUM VIVAX Robert Breiman PARASITES INVOLVED IN SEVERE MANIFESTATIONS Centers for Disease Control and Prevention - Kenya, Nairobi, Kenya Roger Glass Ashis Das Fogarty International Center, Bethesda, MD, United States Birla Institute of Technology and Science, Pilani, Rajasthan, India 4:25 p.m. 3:45 p.m. SPECTRUM AND MORBIDITY PATTERN OF SEVERE ROTAVIRUS: GLOBAL BURDEN OF DIARRHEAL VIVAX MALARIA AND ITS COMPARISON WITH SEVERE DISEASE AND EARLY IMPACT OF VACCINE MANIFESTATION ASSOCIATED WITH FALCIPARUM INTRODUCTION AND MIXED MALARIA (A STUDY FROM BIKANER, Roger Glass NORTHWEST INDIA) Fogarty International Center, National Institutes of Health, Bethesda, MD, United States Sanjay Kumar Kochar S.P. Medical College, Bikaner, India 4 p.m. 4:45 p.m. FINDINGS OF RANDOMIZED, DOUBLE-BLIND CONTROLLED TRIAL OF AN ORAL PENTAVALENT A RANDOMISED, OPEN COMPARATIVE STUDY OF ROTAVIRUS VACCINE IN ASIA (VIETNAM AND DIHYDROARTEMISININ-PIPERAQUINE VERSUS BANGLADESH) CHLOROQUINE FOR THE TREATMENT OF VIVAX MALARIA K. Zaman ICDDR,B, Dhaka, Bangladesh Phyo Aung Shoklo Malaria Research Unit, Mae Sot Tak, Thailand 4:15 p.m. 5:05 p.m. FINDINGS OF RANDOMIZED, DOUBLE-BLIND CONTROLLED TRIAL OF AN ORAL PENTAVALENT IDENTIFICATION OF HOST FACTORS AND LEAD ROTAVIRUS VACCINE IN AFRICA (GHANA, KENYA, AND COMPOUNDS FOR DEVELOPMENT OF NOVEL AGENTS MALI) TARGETING PLASMODIUM-INFECT HEPATOCYTES - CAN THEY BE USED TO TARGET HYPNOZOITE STAGES? Samba O. Sow Center for Vaccine Development-Mali, Bamako, Mali Maria Mota Saturday, November 21 Instituto de Medicina Molecular, Lisboa, Portugal 4:40 p.m. SYNTHESIZING DATA FROM THE FIVE SITES: EVALUATING PUBLIC HEALTH IMPACT Robert Breiman Centers for Disease Control and Prevention - Kenya, Nairobi, Kenya

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4:55 p.m. Sunday, November 22 DISCUSSION OF RESULTS FROM THE TRIALS Robert Breiman Registration Centers for Disease Control and Prevention - Kenya, Nairobi, Kenya Salon Foyer 5:10 p.m. Sunday, November 22, 7 a.m. - 10:30 a.m. ROTAVIRUS VACCINES FOR CHILDREN IN Cyber Cafe DEVELOPING COUNTRIES: NEXT STEPS FOR DISEASE REDUCTION Marriott Foyer Duncan Steele Sunday, November 22, 7 a.m. - 10:30 a.m. PATH, Seattle, WA, United States Speaker Ready Room Maryland A Plenary Session 161 Sunday, November 22, 7 a.m. - Noon Media Room Plenary Session IV: Presidential Address and Business Meeting Rooms 8228/8229 Sunday, November 22, 7:30 a.m. - 1 p.m. Salon 2 Saturday, November 21, 6 p.m. - 7:30 p.m. ASTMH Council Meeting

ASTMH presidential address and annual business meeting. Balcony B Sunday, November 22, 7:30 a.m. - 9:30 a.m. CHAIR Jonathan (Josh) Berman Symposium 163 Fast-Track Drugs and Biologics LLC, North Potomac, MD, United States Christopher L. King Clinical Update: What’s New in Literature Case Western Reserve University, Cleveland, OH, United States Salon 2 6 p.m. Sunday, November 22, 8 a.m. - 9:45 a.m. INTRODUCTION Clinicians in tropical medicine and travelers’ health base their decisions on Christopher V. Plowe University of Maryland School of Medicine, Baltimore, MD, United States the knowledge of disease epidemiology, diagnostic tools, drug resistance patterns and vaccine safety data. This symposium will review the evolving 6:15 p.m. epidemiology, diagnosis, treatment, and prevention of malaria, tuberculosis, infl uenza and yellow fever, with highlights on recently published studies. OPTIMISM, PERSISTENCE AND OUR COLLECTIVE CRYSTAL BALL CHAIR Thomas E. Wellems Lin H. Chen ASTMH President, Rockville, MD, United States Mount Auburn Hospital, Cambridge, MA, United States 6:45 p.m. 8 a.m. ASTMH ANNUAL BUSINESS MEETING MALARIA: CLINICAL UPDATE WITH LITERATURE Jonathan (Josh) Berman HIGHLIGHTS Fast-Track Drugs and Biologics LLC, North Potomac, MD, United States Christoph Hatz Swiss Tropical Institute, Basel, Switzerland Poster Session C Dismantle 8:25 a.m. Exhibit Hall B South YELLOW FEVER: CLINICAL UPDATE WITH LITERATURE Saturday, November 21, 7 p.m. - 8 p.m. HIGHLIGHTS Thomas P. Monath Kleiner Perkins Caulfi eld & Byers Pandemic & Biodefense Fund, Cambridge, MA, United States 8:50 a.m. TUBERCULOSIS: CLINICAL UPDATE WITH LITERATURE HIGHLIGHTS Robert Gilman Johns Hopkins University School of Public Health, Baltimore, MD, United States

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9:15 a.m. Symposium 165 INFLUENZA: CLINICAL UPDATE WITH LITERATURE HIGHLIGHTS The Affordable Medicines Facility-malaria (AMFm) Frederick Hayden University of Virginia, Charlottesville, VA, United States Delaware A Sunday, November 22, 8 a.m. - 9:45 a.m.

Symposium 164 The Affordable Medicines Facility-malaria (AMFm) is a global fi nancing mechanism designed to make good quality ACTs (and other coformulated Pathophysiology, Pathology and Management of Severe drugs, as they are developed) widely available at low “chloroquine” prices Malaria through both the public and private sectors in malaria-endemic countries. These subsidized ACTs should, through market forces, displace more Salon 3 expensive artemisinin monotherapies (which would hasten resistance to artemisinins) and cheaper antimalarials, which now lack effectiveness because Sunday, November 22, 8 a.m. - 9:45 a.m. of resistance. What distinguishes AMFm from other subsidies is its reliance This symposium is presented by the two research groups (working in on existing supply chains to carry subsidized drugs from the highest to the Malawi and Southeast Asia) conducting studies of the pathology of severe lowest links in distribution: from country-level wholesalers to village drug- malaria. Refl ecting on over twenty years of research on the clinical features, sellers. AMFm is available in 13 countries in 2009 and will be in the rest of pathophysiology and management of severe malaria, the similarities and the malaria-endemic world within a few years. From its conception in a 2004 differences in clinical and pathological features of severe malaria in African Institute of Medicine report through to implementation, AMFm has attracted children and Asian adults will be presented and discussed and current controversy and intense debate. Speakers in this symposium will discuss the management reviewed. origins of AMFm and the early stages of its implementation, as well as the current status of ACTs in the private sector. CHAIR CHAIR Nicholas White Mahidol University, Bangkok, Thailand Hellen Gelband Resources for the Future, Washington, DC, United States Malcolm Molyneux Blantyre Malaria Project, Blantyre, Malawi Ramanan Laxminarayan Resources for the Future, Washington, DC, United States 8 a.m. 8 a.m. THE PATHOLOGY OF SEVERE MALARIA SAVING LIVES, BUYING TIME—THE IOM REPORT AND Gareth D. H. Turner Oxford University, Oxford, United Kingdom EARLY STEPS TOWARD A GLOBAL ACT SUBSIDY Ramanan Laxminarayan Dan A. Milner Resources for the Future, Washington, DC, United States Blantyre Malaria Project and Harvard School of Public Health, Boston, MA, United States 8:20 a.m. 8:20 a.m. PUTTING THE SUBSIDY IDEA INTO PRACTICE: THE PATHOPHYSIOLOGY AND CLINICAL FEATURES OF BIRTH OF AMFm SEVERE MALARIA IN MALAWIAN CHILDREN Olusoji Adeyi World Bank, Washington, DC, United States Terrie Taylor Michigan State University, East Lansing, MI, United States 8:45 a.m. 8:45 a.m. TESTING THE GLOBAL SUBSIDY IDEA: THE CHAI PATHOPHYSIOLOGICAL AND CLINICAL FEATURES OF EXPERIENCE SEVERE MALARIA IN ADULTS Oliver Sabot Clinton Foundation, Dar es Salaam, United Republic of Tanzania Nicholas P. Day Mahidol University, Bangkok, Thailand 9:10 a.m. 9:05 a.m. ACTWATCH: PRIVATE SECTOR ACT SUPPLY AND MANAGEMENT OF SEVERE MALARIA QUALITY IN SEVEN COUNTRIES BEFORE AMFm Arjen Dondorp Kathryn O’Connell Mahidol University, Bangkok, Thailand PSI, Nairobi, Kenya 9:25 a.m. GENERAL DISCUSSION AND QUESTIONS Sunday, November 22

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Symposium 166 Scientifi c Session 167

Building Bridges toward Improved IRB Processes through Filariasis - Immunology Capacity Building in Research Ethics in the Developing Virginia AB World Sunday, November 22, 8 a.m. - 9:45 a.m. Delaware B CHAIR Sunday, November 22, 8 a.m. - 9:45 a.m. Marc Hübner Strengthening research ethics review capacity in an era of signifi cant Uniformed Services University of the Health Sciences, Bethesda, MD, United States exporting of clinical trials to the developing world is an essential need. Thomas B. Nutman Recent data showed that 13,521 of 24,206 clinical trial sites being used in National Institutes of Health, Bethesda, MD, United States November 2007 for studies sponsored by the 20 largest U.S. drugmakers were international, and that the number of countries involved in clinical trials has 8 a.m. doubled over the past ten years. Concerns about the inadequacy of proper ethics review systems to effectively protect human subjects and vulnerable 1080 populations, the need to strengthen the local ethical committees or IRBs and the absence of funding allocated to research ethics capacity building through BASOPHILS AUGMENT PARASITE ANTIGEN-SPECIFIC most of the research budget calls for innovations and international liaisons to CD4+ T CELL PROLIFERATION AND EOSINOPHILIA IN A address the need for highly-advanced ethics knowledge, while at the same time MOUSE MODEL OF FILARIASIS applying the procedures and principles to local practices and traditions. The implementation of local regulations may also help address issues of compliance Marina N. Torrero, Marc P. Hübner, David Larson, Ellen Mueller, Edward from both the ethics committees and the investigators. Disregarding this Mitre concern and abandoning research ethics committees to fend for themselves Uniformed Services University of the Health Sciences, Bethesda, MD, United States will only contribute to the rise of ethical disparities in the conduction of human subject research. 8:15 a.m.

CHAIR 1081 A. Roxana Lescano Naval Medical Research Center Detachment Peru, Lima, Peru INCREASED POPULATIONS OF CIRCULATING MYELOID AND PLASMACYTOID DENDRITIC CELLS IN PATENT Barbara Sina Fogarty International Center, National Institutes of Health, Bethesda, MD, United FILARIAL INFECTIONS States Lily Mahapatra1, Benoit Dembele2, Simon Metenou1, Siaka Konate2, Housseini Dolo2, Michel E. Coulibaly2, Lamine Soumaoro2, Rungnapa Panka3, 8 a.m. Damien Chaussabel3, Siaka Y. Coulibaly2, Dramane Sanogo2, Salif Seriba Doumbia2, Abdallah A. Diallo2, Thomas B. Nutman1, Siddhartha Mahanty1, RESEARCH ETHICS TRAINING AND THE NATIONAL Roshanak Tolouei Semnani1 INSTITUTES OF HEALTH 1National Institutes of Health, National Institute of Allergy and Infectious Diseases, Reidar Lie Bethesda, MD, United States, 2Filariasis Unit, FMPOS, University of Bamako, National Institutes of Health, Bethesda, MD, United States Bamako, Mali, 3Baylor Institute for Immunology Research, Baylor University, Dallas, TX, United States 8:25 a.m. 8:30 a.m. RESEARCH ETHICS CAPACITY BUILDING EFFORTS IN INDIA 1082 Nandini Kumar Indian Council of Medical Research, New Delhi, India BASOPHILS AND MAST CELLS BECOME 8:50 a.m. HYPORESPONSIVE IN CHRONIC HELMINTH INFECTIONS RESEARCH ETHICS TRAINING, THE PERUVIAN IRB David Larson, Marc P. Hübner, Marina N. Torrero, Edward Mitre NETWORK EXPERIENCE Uniformed Services University of the Health Sciences, Bethesda, MD, United States A. Roxana Lescano Naval Medical Research Center Detachment Peru, Lima, Peru 8:45 a.m.

9:15 a.m. 1083 THE BRAZILIAN SYSTEM OF RESEARCH ETHICS REVIEW PRE-EXISTING FILARIAL INFECTION INFLUENCES CYTOKINE PRODUCTION DURING ACUTE MALARIA Dirce Guilhem Universidade de Brasilia, Brasilia, Brazil IN CHILDREN AND YOUNG ADULTS IN A COENDEMIC REGION OF MALI Benoit Dembele1, Simon Metenou2, Housseini Dolo1, Siaka Konate1, Siaka Y. Coulibaly1, Dramane Sanogo1, Siddhartha Mahanty2, Michel E. Coulibaly1, Lamine Soumaoro1, Salif S. Doumbia1, Abdallah A. Diallo1, Merepin A. Guindo1, Dapa A. Diallo1, Sekou F. Traore1, Yaya I. Coulibaly1, Thomas B. Nutman2, Amy D. Klion2 1University of Bamako, Bamako, Mali, 2National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, MD, United States

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9 a.m. and will coordinate a network of sites focusing on populations with a high prevalence of malnutrition and enteric infections. The sites, including those in 1084 Peru, Brazil, Bangladesh, India, Pakistan, Tanzania, South Africa and Nepal, will conduct comprehensive studies using shared protocols to determine the PATENT FILARIAL INFECTION MODULATES THE factors that impact early childhood growth and cognitive development. These studies will allow us to elucidate some of the complex relationships between QUALITY OF T CELL RESPONSES TO MALARIAL enteric infection and malnutrition, leading to more targeted, cost-effective ANTIGENS IN MALARIA/FILARIAL CO-ENDEMIC interventions that will further reduce the burden of disease for those living in VILLAGE OF MALI poverty. Simon Metenou1, Benoit Dembele2, Siaka Konate2, Housseini Dolo2, Lamine Soumaoro2, Abdallah A. Diallo2, Michel E. Coulibaly2, Siaka Y. Coulibaly2, CHAIR Dramane Sanogo2, Yaya I. Coulibaly2, Sekou F. Traore2, Siddhartha Mark A. Miller Mahanty1, Amy D. Klion1, Thomas B. Nutman1 National Institutes of Health, Bethesda, MD, United States 1National Institutes of Health, Bethesda, MD, United States, 2Filaria Unit, FMPOS, University of Bamako, Mali, Bamako, Mali Michael Gottlieb Foundation for the National Institutes of Health, Bethesda, MD, United States (ACMCIP Abstract) 9:15 a.m. 8 a.m. GLOBAL EPIDEMIOLOGY OF DIARRHEAL DISEASE 1085 Mark A. Miller National Institutes of Health, Bethesda, MD, United States ATTENUATION OF TLR EXPRESSION AND FUNCTION IN LATENT TUBERCULOSIS BY COEXISTENT FILARIAL 8:25 a.m. INFECTION WITH RESTORATION FOLLOWING DETERMINING DIARRHEAL ETIOLOGY IN THE MAL-ED ANTIFILARIAL CHEMOTHERAPY STUDY Subash Babu1, Sajid Q. Bhat1, Pavan Kumar1, R. Anuradha1, Paul Kumaran2, Eric Houpt P. G. Gopi2, C. Kolappan2, V. Kumaraswami2, Thomas B. Nutman3 University of Virginia, Charlottesville, VA, United States 1National Institutes of Health-TRC-ICER, Chennai, India, 2Tuberculosis Research Center, Chennai, India, 3National Institutes of Health, Bethesda, MD, United States 8:50 a.m. 9:30 a.m. EFFECTS OF ENTERIC DISEASES ON COGNITIVE DEVELOPMENT 1086 Richard Guerrant University of Virginia, Charlottesville, VA, United States HELMINTH-MEDIATED PROTECTION AGAINST AUTOIMMUNE DIABETES IN NOD MICE IS NOT 9:15 a.m. DEPENDENT ON A TH2 IMMUNE SHIFT THE LINK BETWEEN ENTERIC INFECTIONS AND Marc P. Hübner, Marina N. Torrero, Ellen Mueller, David Larson, J. MALNUTRITION Thomas Stocker, Edward Mitre Laura Caulfi eld Uniformed Services University of the Health Sciences, Bethesda, MD, United States The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States Symposium 168 Scientifi c Session 169

MAL-ED: A Study of the Effects of Enteric Diseases and Mosquitoes - Insecticide Resistance and Control Malnutrition on Child Growth and Development in Eight Resource-Poor Countries Washington 1 Sunday, November 22, 8 a.m. - 9:45 a.m. Virginia C CHAIR Sunday, November 22, 8 a.m. - 9:45 a.m. William Black One in every fi ve children in the developing world is malnourished and Colorado State University, Fort Collins, CO, United States poor nutrition is linked to more than half of all child deaths worldwide. Karla L. Saavedra-Rodriguez Early childhood malnutrition is considered one of the most prevalent risk Colorado State University, Fort Collins, CO, United States factors for morbidity and mortality in children under fi ve and may lead to cognitive and physical defi cits later in life. This vicious cycle of malnutrition 8 a.m. is compounded by the tremendous enteric infectious disease burden of children in the developing world. These infections alter gut integrity, impair 1087 absorption of nutrients and the resulting malnutrition increases susceptibility to and incidence of further infection and diminished immune response to INDOOR USE OF CARBAMATE TREATED PLASTIC vaccines. Moreover, high rates of disease, malnutrition and impaired child development place an enormous and disproportionate burden on poor families SHEETING IN COMBINATION WITH LONG LASTING and on the social and economic stability of the countries where they occur. INSECTICIDAL NETS TO CONTROL PYRETHROID Understanding the complex and synergistic relationship between enteric RESISTANT MALARIA VECTORS IN WEST AFRICA infections and malnutrition is fundamental to the design of better intervention Djenontin Armel strategies. This symposium will present the goals and organization of a study CREC/IRD, Cotonou, Benin being conducted in eight poorly-resourced countries by researchers in a new

project known as MAL-ED. The MAL-ED Consortium has established Sunday, November 22

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8:15 a.m. 9:30 a.m.

1088 1093

MULTIPLE INSECTICIDE RESISTANCE AMONG WILLINGNESS TO PAY FOR VECTOR CONTROL FOR ANOPHELES GAMBIAE IN URBAN AGRICULTURAL AREAS THE ASIAN TIGER MOSQUITO IN NEW JERSEY OF COTONOU, BENIN (WEST AFRICA) Yara A. Halasa1, Donald S. Shepard1, Dina Fonseca2, Ary Farajollahi3, Sean Moussa B. Cisse1, Thierry Baldet1, Fabrice Chandre2, Joseph Chabbi1, Jean Healy4, Randy Gaugler2, Gary G. Clark5 M. Hugard2, Martin Akogbeto1, Ousmane A. Koita3, Donald J. Krogstad4 1Brandeis University, Waltham, MA, United States, 2Rutgers University, New 1Centre de Recherche Entomologique de Cotonou (CREC), Cotonou, Benin, 2Institut Brunswick, NJ, United States, 3Mercer County Mosquito Control, West Trenton, NJ, de Recherche pour le Developpement (IRD), Cotonou, Benin, 3Laboratoire de Biologie United States, 4Monmouth County Mosquito Control Commission, Tinton Falls, NJ, Moleculaire Appliquee, Facultes des Sciences et Techniques (FAST), Bamako, Mali, United States, 5United States Department of Agriculture, Gainesville, FL, United States 4Tulane University Health Sciences Center, New Orleans, LA, United States Scientifi c Session 170 8:30 a.m.

1089 Flavivirus - West Nile Virus Washington 2 THE POTENTIAL FOR MALARIA CONTROL USING Sunday, November 22, 8 a.m. - 9:45 a.m. FUNGAL BIOPESTICIDES Matt Thomas, Simon Blanford, Andrew Read CHAIR Pennsylvania State University, University Park, PA, United States Doug E. Brackney University of New Mexico, Albuquerque, NM, United States 8:45 a.m. Heidi Smith University of Massachusetts Medical Center, Worcester, MA, United States 1090 8 a.m. INSENSITIVE ACETYLCHOLINESTERASE (ACE.1R): EVENTS OF INTROGRESSION AND DUPLICATION 1094 BETWEEN THE MOLECULAR M AND S FORMS OF ANOPHELES GAMBIAE S.S. WEST NILE VIRUS GENETIC DIVERSITY AND RNA Luc S. Djogbénou1, Mylène Weill2, Jean-Marc Hougard3, Fabrice Chandre3, INTERFERENCE IN THE MOSQUITO CULEX PIPIENS Roch Dabire4 QUINQUEFASCIATUS 1 2 Institut Régional de Santé Publique/IRD, Cotonou, Benin, Equipe Génétique de Doug E. Brackney1, Jennifer E. Beane2, Gregory D. Ebel1 3 l’Adaptation/Université Montpellier, Montpellier, France, Institut de Recherche pour 1University of New Mexico, Albuquerque, NM, United States, 2Boston University Medical 4 le Developpement, Montpellier, France, Institut Régional des Sciences de Santé, Bobo- Center, Boston, MA, United States Dioulasso, Burkina Faso 8:15 a.m. 9 a.m. 1095 1091 THE EFFECT OF MOSQUITO SALIVA ON THE CHANGES IN THE TRANSCRIPTION OF INTERACTION OF WEST NILE VIRUS AND ITS DETOXIFICATION GENES IN RESPONSE TO SELECTION VERTEBRATE HOST WITH TEMEPHOS AND PERMETHRIN IN AEDES AEGYPTI Pei-Yin Lim, Linda M. Styer, Laura D. Kramer, Kristen A. Bernard 1 2 1 Karla Saavedra-Rodriguez , Clare Strode , Guadalupe Reyes-Solis , Adriana Wadsworth Center, Slingerlands, NY, United States Flores-Suarez3, Hilary Ranson2, Janet Hemingway2, William Black IV1 1Colorado State University, Fort Collins, CO, United States, 2Liverpool School of 8:30 a.m. Tropical Medicine, Liverpool, United Kingdom, 3Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Mexico 1096 9:15 a.m. AVIAN HOSTS OF WEST NILE VIRUS IN PUERTO RICO 1092 Nicholas Komar1, Elizabeth Hunsperger2, Kovi Bessoff2, Annette Diaz2, Manuel Amador2, Ginger Young1, Rafael Seda3, Taonex Perez3, Roberto OPTIMIZATION OF A HOST-SEEKING MOSQUITO TRAP Barrera2 1 2 FOR INTEGRATION INTO AN AEDES AEGYPTI PUSH-PULL Centers for Disease Control and Prevention, Fort Collins, CO, United States, Centers for Disease Control and Prevention, San Juan, PR, United States, 3Puerto Rico CONTROL STRATEGY Department of Health, San Juan, PR, United States Ferdinand V. Salazar1, Theeraphap Chareonviriyaphap1, Nicole Achee2 1Kasetsart University, Bangkok, Thailand, 2Uniformed Services University of the Health Sciences, Bethesda, MD, United States

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8:45 a.m. Symposium 171 1097 The Fever from the Forest: Fifty Years of Research on THE IMPACT OF WEST NILE VIRUS ON THE Sylvatic Dengue Virus ABUNDANCE OF NORTH AMERICAN BIRDS Washington 3 1 1 2 Ivo M. Foppa , Raphaelle H. Beard , Md Monir Hossain Sunday, November 22, 8 a.m. - 9:45 a.m. 1Tulane University, New Orleans, LA, United States, 2University of Texas, Houston, TX, United States The goal of this symposium is to inform the scientifi c community about the history, current status and future directions of research on sylvatic dengue 9 a.m. virus, an important yet underappreciated component of the dengue virus (DENV) transmission cycle. DENV are members of the genus Flavivirus 1098 in the family Flaviviridae and include four antigenically distinct serotypes (DENV-1-4). In the last half-century, DENV have emerged as the most WEST NILE VIRUS INDUCES MULTIPLE MATRIX important arboviral pathogens in tropical and subtropical regions throughout METALLOPROTEINASES (MMP) IN HUMAN the world, putting one-third of the human population at risk of infection. The ASTROCYTES: ROLE IN TIGHT JUNCTION PROTEIN transmission of DENV includes a sylvatic, enzootic cycle, most likely between non-human primates and arboreal Aedes mosquitoes, and an urban, endemic/ (TJP) DEGRADATION AND BLOOD-BRAIN BARRIER epidemic cycle between peridomestic Aedes mosquitoes and human reservoir (BBB) DISRUPTION hosts. Phylogenetic analyses suggest that the four currently circulating Saguna Verma, Mukesh Kumar, Ulziijargal Gurjav, Stephanie Lum, Vivek R. urban DENV serotypes emerged independently from ancestral sylvatic Nerurkar progenitors in the forests of southeast Asia after the establishment of urban University of Hawaii, Honolulu, HI, United States populations large enough to support continuous interhuman transmission. In this symposium we will examine the sylvatic origins of DENV, including 9:15 a.m. ecology, adaptation for urban transmission and molecular epidemiology, as well as the forces that have shaped the molecular evolution of extant sylvatic 1099 DENV strains. The potential for sylvatic DENV to re-emerge into the human transmission cycle in the face of immunity to current urban strains or CHARACTERIZATION OF ANTIGEN-SPECIFIC MEMORY vaccine candidates currently under development will also be discussed. The CD8+ T CELLS FOLLOWING LIVE-ATTENUATED topics addressed in this symposium will provide an overview of how sylvatic CHIMERIC WEST NILE VIRUS VACCINATION DENV population dynamics and transmission infl uence emergence and why, therefore, the study of sylvatic DENV is critical to the prediction of future 1 2 1 1 Heidi Smith , Thomas P. Monath , Pamela Pazoles , Alan L. Rothman , DENV emergence. Francis A. Ennis1, Farshad Guirakhoo3, Sharone Green1 1 2 University of Massachusetts Medical School, Worcester, MA, United States, Kleiner CHAIR Perkins Caufi eld & Byers, Menlo Park, CA, United States, 3Sanofi Pasteur, Marcy l’Etoile, France Nikos Vasilakis University of Texas Medical Branch, Galveston, TX, United States 9:30 a.m. Kathryn A. Hanley New Mexico State University, Las Cruces, NM, United States 1100 8 a.m. VACCINATION OF WILDLIFE TO CONTROL ZOONOTIC ECOLOGY AND EPIDEMIOLOGY OF SYLVATIC DENGUE DISEASE: WEST NILE VIRUS AS A CASE STUDY IN WEST AFRICA A. Marm Kilpatrick1, Ryan J. Peters2, Matthew J. Jones3, Peter P. Marra4, Amadou A. Sall Peter Daszak5, Laura D. Kramer3 Institut Pasteur de Dakar, Dakar, Senegal 1University of California, Santa Cruz, Santa Cruz, CA, United States, 2George Mason University, Fairfax, VA, United States, 3New York State Department of Health, Albany, 8:25 a.m. NY, United States, 4Smithsonian Migratory Bird Center, Washington, DC, United States, 5Wildlife Trust, New York, NY, United States EVOLUTIONARY PATTERNS IN SYLVATIC DENGUE VIRUS Eddie Holmes The Pennsylvania State University, University Park, PA, United States 8:50 a.m. AND IN A SURPRISE MOVE…A RECENT CASE OF DENGUE HEMORRHAGIC FEVER DUE TO SYLVATIC DENGUE VIRUS INFECTION IN MALAYSIA Jane M. Cardosa Universiti Malaysia Sarawak, Sarawak, Malaysia 9:15 a.m. INSIGHTS FROM THE BENCH: EXPERIMENTAL STUDIES OF SYLVATIC DENGUE VIRUS Nikos Vasilakis University of Texas Medical Branch, Galveston, TX, United States Sunday, November 22

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Symposium 172 Symposium 173

Infl uenza in the Developing World: Advances in Defi ning Complexities of Measuring Hygiene Behavior and Health Burden and Considerations for Prevention and Preparedness Outcomes: How Do We Best Evaluate Low-Technology Solutions to Reducing Global Diarrhea Burden? Washington 4 Sunday, November 22, 8 a.m. - 9:45 a.m. Washington 5 Sunday, November 22, 8 a.m. - 9:45 a.m. In recent years, there have been new data from tropical countries in the developing world where there was essentially no information on infl uenza, Low-technology solutions such as handwashing with soap and point-of- confi rming that infl uenza is an important threat. At the 2008 ASTMH annual use water treatment are increasingly being implemented to alleviate the meeting, a symposium was presented with early data from comprehensive high burden of diarrheal disease morbidity and mortality in resource-poor surveillance established recently in fi ve countries in Africa, Asia and Latin settings. Evaluating these programs using effi cacy and effectiveness studies America: Kenya, Egypt, Thailand, Bangladesh and Guatemala. The symposium is challenging because of the complexities of measuring hygiene behavior and was widely acclaimed as providing new and exciting information, and set the health outcomes. This symposium will provide a wealth of evidence regarding stage for a follow-up symposium, during which an anticipated wealth of new these complexities and provide recommendations for measuring hygiene data from these settings would be available. New data that defi nes burden of behavior and health outcomes in a variety of research and program settings. disease and risk factors for transmission in these countries will be presented. The cross-cutting theme of the presentations and discussion will be to focus CHAIR on applying these new data to formulate and evaluate optimal cost-effective strategies for immunization and infection control to decrease burden of disease Pavani K. Ram University at Buffalo, Buffalo, NY, United States associated with infl uenza, along with adapting surveillance approaches in the developing world to detect and respond to emerging respiratory pathogen Stephen P. Luby threats, including pandemic infl uenza. International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

CHAIR 8 a.m. Robert Breiman RAPID SPOT CHECK FOR SOAP AND WATER: A USEFUL Centers for Disease Control and Prevention-Kenya, Nairobi, Kenya PROXY TO ASSESS HANDWASHING BEHAVIOR? Tim Uyeki Stephen P. Luby Centers for Disease Control and Prevention, Atlanta, GA, United States International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh 8 a.m. 8:20 a.m. USING A VARIETY OF SURVEILLANCE TOOLS TO CAN PROXY MEASURES OF HANDWASHING BEHAVIOR ASSESS BURDEN AND TO FORMULATE PREVENTION PREDICT DIARRHEA OUTCOMES? COMPARING STRATEGIES FOR KENYA MULTIPLE HANDWASHING INDICATORS AND Emma Lebo HOUSEHOLD DISEASE OUTCOMES Centers for Disease Control and Prevention-Kenya, Nairobi, Kenya Robert Dreibelbis Johns Hopkins University, Baltimore, MD, United States 8:20 a.m. A TALE OF TWO CLIMATES: THE EPIDEMIOLOGY OF 8:40 a.m. INFLUENZA IN THE HIGHLANDS AND LOWLANDS OF RECALL ERRORS IN A WEEKLY DIARRHEAL SURVEY IN GUATEMALA GUATEMALA: DETERMINING THE OPTIMAL LENGTH OF Kim Lindblade RECALL Centers for Disease Control and Prevention-Guatemala, Guatemala City, Guatemala Syed Nabeel Zafar Aga Khan University, Karachi, Pakistan 8:40 a.m. MODELING THE NATIONAL BURDEN OF INFLUENZA IN 9:05 a.m. BANGLADESH MEASURING DIARRHEA: QUANTIFYING HAWTHORNE Eduardo Azziz-Baumgartner EFFECTS IN FREQUENTLY COLLECTED DATA International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh Clair C. Null SURVEILLANCE FOR INFLUENZA IN THE MIDDLE EAST: Emory University, Atlanta, GA, United States EMERGING PERSPECTIVES 9:25 a.m. Maha Talaat NAMRU-3, Cairo, Egypt RECONTAMINATION OF HANDS FOLLOWING THOROUGH HANDWASHING WITH SOAP: LESSONS 9:20 a.m. FOR HAND CONTAMINATION MEASUREMENT AND TRANSITIONING FROM SURVEILLANCE TO POLICY: THE HANDWASHING PROMOTION IN RESOURCE-POOR EVOLVING STORY IN THAILAND SETTINGS Mark Simmerman Pavani Kalluri Ram Thailand - United States Collaboration, Bangkok, Thailand University at Buffalo, Buffalo, NY, United States

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Scientifi c Session 173A 8:45 a.m. 1076 Malaria - Vaccines II Washington 6 A PHASE 1 TRIAL OF A BIVALENT MSP2 BLOOD-STAGE Sunday, November 22, 8 a.m. - 9:45 a.m. MALARIA VACCINE FORMULATED WITH MONTANIDE ISA 720 CHAIR James S. McCarthy1, Joanne Marjason2, Suzanne Elliott2, Paul Fahey3, Kazutoyo Miura Elissa Malkin3, Eveline Tierney3, Nadia Cross4, Jack S. Richards4, Michelle National Institute of Allergy and Infectious Diseases/National Institutes of Health, Boyle4, Gilles Bang5, Carole Long6, Pierre Druilhe5, James Beeson4, Robin F. Rockville, MD, United States Anders7 1QIMR, University of Queensland, Brisbane, Australia, 2Q-Pharm Pty Ltd, Brisbane, Mahamadou Thera 3 4 MRTC/DEAP/FMPOS, Bamako, Mali Australia, PATH Malaria Vaccine Initiative, Bethesda, MD, United States, Walter and Eliza Hall Institute, Melbourne, Australia, 5Paster Institute, Paris, France, 6 8 a.m. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States, 7Department of Biochemistry, La Trobe University, 1073 Melbourne, Australia 9 a.m. ASSESSMENT OF FIELD SITES FOR CLINICAL TRIALS OF A NEW MALARIA VACCINE IN AFRICA 1077 Matthew B. Laurens1, Bernhards R. Ogutu2, Laurence Lemiale3, Karl C. Kronmann4, Linda Rosendorf5, Christopher V. Plowe1 NEUTRALIZING ANTIBODY TITERS TO SIMIAN 1Howard Hughes Medical Institute/Center for Vaccine Development, University of ADENOVIRAL VECTORS FOLLOWING ADCH63 ME-TRAP 2 Maryland School of Medicine, Baltimore, MD, United States, INDEPTH-Malaria IMMUNIZATION IN HUMANS Clinical Trials Alliance, Kisumu, Kenya, 3PATH Malaria Vaccine Initiative, Bethesda, MD, United States, 4United States Navy Medical Research Unit No. 3, Ghana Anna L. Goodman1, Geraldine O’Hara1, Katie Ewer1, Katharine Collins1, Detachment, Accra, Ghana, 5Independent Consultant, Bethesda, MD, United States Nick Edwards1, Arturo Reyes-Sandoval1, Alison Lawrie1, Alfredo Nicosia2, Stefano Colloca2, Sarah C. Gilbert1, Adrian V. Hill1 8:15 a.m. 1The Jenner Institute, University of Oxford, United Kingdom, 2Okairos, Rome, Italy

1074 9:15 a.m. 1078 RANDOMIZED, CONTROLLED, PHASE 2B CLINICAL TRIAL TO EVALUATE THE SAFETY, IMMUNOGENICITY SAFETY, TOLERABILITY, IMMUNOGENICITY AND AND EFFICACY OF WRAIR’S AMA-1 MALARIA VACCINE PROTECTIVE EFFICACY OF AN ADENOVIRUS- (FMP2.1) ADJUVANTED IN GSK BIOLOGICALS’ AS02A VECTORED P. FALCIPARUM MALARIA VACCINE IN VS. RABIES VACCINE IN 1-6 YEAR OLD CHILDREN IN HEALTHY, MALARIA-NAÏVE ADULTS BANDIAGARA, MALI 1 1 1 1 1 1 1 1 1 C. Tamminga , M. Sedegah , I. Chuang , D. Regis , J.E. Epstein , M. Spring , Mahamadou A. Thera , Ogobara K. Doumbo , Drissa Coulibaly , Matthew B. 1 1 1 1 1 2 1 1 1 1 J. Mendoza-Silveiras , V. Steinbeiss , C. Fedders , S. Reyes , F. Parekh , Laurens , Abdoulaye Kone , Ando Guindo , Dapa A. Diallo , Karim Traore , 2 1 1 1 1 1 1 1 1 F. Williams , K. Smith , S. Maiolatesi , D.L. Doolan , K. Limbach , N. B. Bourema Kouriba , Issa Diarra , Amagana Dolo , Amadou Niangaly , Modibo 1 3 3 4 4 1 1 1 1 3 3 Patterson , J. Bruder , C.R. King , L. Soisson , C. Diggs , C. Ockenhouse , Daou , Mady Sissoko , Drissa Traore , Kirsten E. Lyke , Shannon Takala , 1 4 4 4 5 T.L. Richie Olivier Godeaux , Joelle Thonnard , Joe Cohen , David Lanar , Carter 1 6 6 5 2 United States Military Malaria Vaccine Program, Naval Medical Research Center/ Diggs , Lorraine Soisson , Donald G. Heppner , Christopher V. Plowe 2 1 2 Walter Reed Army Institute of Research, Silver Spring, MD, United States, National MRTC/DEAP/FMPOS - University of Bamako, Bamako, Mali, CVD-University of 3 3 Naval Medical Center, Bethesda, MD, United States, GenVec Inc., Gaithersburg, MD, Maryland, Baltimore, MD, United States, CVD - University of Maryland, Baltimore, 4 4 5 United States, United States Agency for International Development, Washington, DC, MD, United States, GlaxoSmithKline Biologicals, Rixensart, Belgium, Walter Reed United States Army Institute of Research, Silver Spring, MD, United States, 6United States Agency for International Development, Washington, DC, United States 9:30 a.m. 8:30 a.m. 1079 1075 DEVELOPMENT OF A SAFE AND REPRODUCIBLE IMPACT OF PLASMODIUM FALCIPARUM APICAL HUMAN SPOROZOITE CHALLENGE MODEL FOR MEMBRANE ANTIGEN 1-COMBINATION 1/ALHYDROGEL PLASMODIUM VIVAX IN HEALTHY ADULTS IN THE VACCINE ON GROWTH-INHIBITORY ACTIVITY OF UNITED STATES ANTIBODIES IN CHILDREN IN MALI Ilin Chuang1, Jetsumon Prachumsri2, David Fryauff1, Jitta Murphy3, 2 2 3 3 1 2 2 2 David Saunders , Jason Richardson , Donna Tosh , Jack Williams , Delia Kazutoyo Miura , Hong Zhou , Ababacar Diouf , Gregory Tullo , Joan A. 2 1 3 3 2 1 1 1 3 3 Bethell , Thomas L. Richie , Lisa Ware , Michele Spring , Mark Fukuda , Aebig , Louis H. Miller , Allan Saul , Ogobara K. Doumbo , Issaka Sagara , 1 3 3 3 3 2 1 Cindy Tamminga , James Cummings , April Kathcart , Anjali Yadava , Jack Alassane Dicko , Carole A. Long , Ruth D. Ellis 3 3 3 3 1 Komisar , Mike O’Neil , Mark Polhemus , Christian F. Ockenhouse Malaria Vaccine Development Branch/National Institute of Allergy and Infectious 1 2 2 Naval Medical Research Center, Silver Spring, MD, United States, Armed Forces Diseases/National Institutes of Health, Rockville, MD, United States, Laboratory of Research Institute of Medical Sciences, Bangkok, Thailand, 3Walter Reed Army Institute Malaria and Vector Research/National Institute of Allergy and Infectious Diseases/ of Research, Silver Spring, MD, United States National Institutes of Health, Rockville, MD, United States, 3Malaria Research and Training Center/ Faculty of Medicine Pharmacy and Dentistry/University of Bamako, Bamako, Mali Sunday, November 22

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Coffee Break 11:05 a.m. Marriott Foyer THE RISKS ASSOCIATED WITH TB TRANSMISSION ON INTERNATIONAL BUS TRAVEL AND PRACTICAL Sunday, November 22, 9:45 a.m. - 10:15 a.m. ISSUES IN PURSUING CROSS-BORDER CONTACT INVESTIGATIONS Symposium 174 Paul Edelson Centers for Disease Control and Prevention, New York, NY, United States Cross Border Travel Bugs: Global Migration and Health Right in our Backyard 11:30 a.m. PUBLIC HEALTH INFORMATION SHARING ALONG Salon 1 THE CANADA-U.S. BORDER: OPPORTUNITIES FOR Sunday, November 22, 10:15 a.m. - Noon IMPROVEMENT On May 23, 2005, the World Health Assembly of the International Health André La Prairie Regulations (IHR) was adopted by member countries. One aim of the IHR Public Health Agency of Canada, Ottawa, ON, Canada is to “better respond to the increasing interaction between countries of the world, and to the changing nature of public health threats”. IHR Article 44 Scientifi c Session 175 affi rmed that “State Parties shall undertake to collaborate with each other” to identify, investigate and respond to events and provide technical and Clinical Tropical Medicine III logistic support. The United States shares northern and southern borders with Canada and Mexico respectively. Each year, more than 300 million Salon 2 persons travel across these borders. Some are potentially infectious or are carrying infected animals and/or cargo. For communities on these borders, Sunday, November 22, 10:15 a.m. - Noon the borders themselves are indistinct, thus local public health offi cials must CHAIR share epidemiologic information between the respective countries regarding Enrico Brunetti all epidemiologic events of mutual interest. This session will explore efforts University of Pavia, Pavia, Italy by governments on the borders to improve information-sharing during public health events and develop sharing agreements and outline the binational Sabine Mand University of Bonn, Bonn, Germany procedures currently in place to ensure effective surveillance and reporting of pubic health events of mutual interest. Specifi c examples will include a Public 10:15 a.m. Health Agency of Canada’s Offi ce of Public Health Policy study looking at the status of information-sharing arrangements and related issues along the Canada-United States border, and a model cross border case management 1101 and referral program for tuberculosis and the current status of binational collaborative efforts between Mexico and the U.S. The session will use TB COMPARISON OF P29, B2T AND EGHF DIAGNOSTIC case examples to highlight challenges for local public health response on PERFORMANCE (ELISA) IN PATIENTS WITH both sides posed by infectious border crossers to evaluate the risks to other RESIDUAL CAVITIES AFTER SURGERY FOR CYSTIC travelers and to coordinate binational contact investigations and will discuss ECHINOCOCCOSIS issues and complex dynamics of tuberculosis control among migrating and 1 2 3 4 mobile populations across both borders. Enrico Brunetti , Mar Siles-Lucas , Norbert Mueller , Maria Chiara Cerutti , Valeria D’Amico4, Chiara Bazzocchi4, Carlo Filice1, Bruno Gottstein3 1University of Pavia - IRCCS S.Matteo Hospital Foundation, Pavia, Italy, 2Consejo CHAIR Superior de Investigaciones Científi cas, Salamanca, Spain, 3Institute of Parasitology - Clive M. Brown University of Bern, Bern, Switzerland, 4University of Milan, Milan, Italy Centers for Disease Control and Prevention, Atlanta, GA, United States Steve Waterman 10:30 a.m. Centers for Disease Control and Prevention, Atlanta, GA, United States 1102 10:15 a.m. CHALLENGES AND OBSTACLES FOR IMPLEMENTING DOXYCYCLINE IMPROVES FILARIAL LYMPHOEDEMA EFFECTIVE CROSS-BORDER INFECTIOUS DISEASE INDEPENDENT FROM ITS ACTION ON WOLBACHIA SURVEILLANCE AND CONTROL ALONG THE U.S.- Sabine Mand1, Alexander Y. Debrah2, Sabine Specht1, Alexander Kwarteng3, 4 1 3 3 MEXICO BORDER Rolf Fimmers , Ute Klarmann , Linda Batsa , Yeboah Marfo-Debrekyei , Ohene Adjei3, Achim Hoerauf1 Miguel Escobedo 1Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Centers for Disease Control and Prevention, El Paso, TX, United States Bonn, Germany, 2School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, 3Kumasi Centre for Collaborative Research in Tropical 10:40 a.m. Medicine (KCCR), Kumasi, Ghana, 4Institute for Medical Biometry, Informatics and THE EXISTING FRAMEWORK FOR EFFECTIVE Epidemiology, University of Bonn, Bonn, Germany BINATIONAL TUBERCULOSIS CONTROL ACTIVITIES CURRENTLY IN PLACE ALONG THE U.S.-MEXICO BORDER Martin Castellanos Mexico Secretariat of Health, Mexico City, Mexico

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10:45 a.m. Scientifi c Session 176 1103 American Committee of Molecular, Cellular and EFFECT OF HIGH DOSE INTRAVENOUS Immunoparasitology (ACMCIP): Molecular Parasitology II DEXAMETHASONE IN THE TREATMENT OF TYPHOID Supported with funding from the Burroughs Wellcome Fund ENCEPHALOPATHY AMONG BANGLADESHI PATIENTS Salon 3 Pradip K. Bardhan, Mohammad J. Chisti, Sayeeda Huq, Wasif A. Khan, Sunday, November 22, 10:15 a.m. - Noon Mohammad A. Salam International Center for Diarrheal Disease Research, Dhaka, Bangladesh CHAIR Joanna Bridger 11 a.m. Brunel University, Middlesex, United Kingdom 1104 Godfrey O. Lisk National Institutes of Health, Rockville, MD, United States THE ETIOLOGIES OF ACUTE UNDIFFERENTIATED 10:15 a.m. FEBRILE ILLNESS IN AN ADULT COHORT IN BANDUNG, INDONESIA (2000-2008) 1153 Panji I. Rudiman1, Bachti Alisjahbana1, Herman Kosasih2, Primal Sudjana1, Hadi Jusuf1, Timothy H. Burgess2, Maya Williams2 PROFILING THE TRANSCRIPTIONAL LANDSCAPE IN 1Medical Faculty, Padjadjaran University, Bandung, Indonesia, 2United States Naval TRYPANOSOMA BRUCEI BY MRNA NEXT-GENERATION Medical Research Unit 2, Jakarta, Indonesia SEQUENCING 11:15 a.m. Nikolay G. Kolev1, Joseph B. Franklin2, Shai Carmi3, Huafang Shi4, Shulamit Michaeli3, Elisabetta Ullu2,4, Christian Tschudi1 1105 1School of Public Health, Yale University, New Haven, CT, United States, 2Department of Cell Biology, Yale University Medical School, New Haven, CT, United States, 3The THE ASSOCIATION BETWEEN KHAT CHEWING AND Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel, 4Department of Internal Medicine, Yale University School of Medicine, New TOBACCO SMOKING AMONG STUDENTS OF THE Haven, CT, United States COLLEGE OF HEALTH SCIENCES FOR MALES IN JAZAN, SAUDI ARABIA 10:30 a.m. Yasser A. Hassan College of Health Sciences, Jazan, Saudi Arabia 1154

11:30 a.m. EXPORT OF MALARIAL VIRULENCE PROTEINS THAT REMODEL INFECTED HUMAN ERYTHROCYTES 1106 Justin A. Boddey1, Anthony N. Hodder1, Svenja Gunther1, Paul R. Gilson2, Heather Patsiouras3, Eugene A. Kapp3, J. Andrew Pearce1, Richard J. OUTBREAKS OF PUFFER FISH INTOXICATION Simpson3, Brendan S. Crabb2 and Alan F. Cowman1 FOLLOWING CONSUMPTION OF MARINE PUFFER FISH 1The Walter and Eliza Hall Institute for Medical Research, Melbourne, Victoria, IN BANGLADESH, 2008 Australia, 2Macfarlane Burnet Institute for Medical Research and Public Health, Nusrat Homaira1, Mahmudur Rahman2, Stephen P. Luby1, Mustafi zur Melbourne, Victoria, Australia, 3Ludwig Institute for Cancer Research and The Walter Rahman2, Mohammad Sabbir Haider2, Labib Imran1, Dawlat Khan1, Shahana and Eliza Hall Institute for Medical Research, Melbourne, Victoria, Australia Parveen1, Emily S. Gurley1 1International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, 10:45 a.m. 2IEDCR, Dhaka, Bangladesh 1108 11:45 a.m. A GENE LINKED TO A NEW ANTIMALARIAL DRUG 1107 RESISTANCE MECHANISM: REDUCED UPTAKE BY INFECTED ERYTHROCYTES ETHICAL IMPLICATIONS OF INFORMED CONSENT Godfrey Lisk, Sanjay A. Desai IN EMERGENT CLINICAL SITUATIONS IN A “BUSH HOSPITAL” IN MALI National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States Jessica E. Manning1, Christopher V. Plowe2, Ogobara Doumbo1 1Malaria Research and Training Center, University of Bamako, Bamako, Mali, 2Howard Hughes Medical Institute/Center for Vaccine Development, University of Maryland, Baltimore, MD, United States Sunday, November 22

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11:00 a.m. Symposium 177 1109 Striking The Balance: Enhancing the Livelihoods and CYTOKINE GENE SNPS ARE ASSOCIATED WITH SEVERE Health of Persons Living in the Developing World While MALARIA IN VIETNAM Minimizing the Impact of Habitat Loss and Disease N.T.N. Quyen1, N.H. Phu2, C.Q. Thai2, T.T. Hien2, J.J. Farrar1, S.J. Transmission Dunstan1, The MalariaGEN Consortium3 Delaware A 1Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam, 2Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam, 3www. Sunday, November 22, 10:15 a.m. - Noon malariagen.net, Oxford, United Kingdom Globally, loss of habitat and biodiversity and environmental change is 11:15 a.m. occurring at an ever increasing pace. Numerous factors such as logging, crop development, road construction, mining, livestock production and 1110 advancement of human settlements are largely to blame for the demise of the environment. While at the same time, the world’s population continues to grow without an increase in these renewable resources. In addition, there is MEK/ERK SIGNALING AND REACTIVE OXYGEN SPECIES mounting evidence suggesting that this loss of biodiversity is contributing to REGULATE THE MOSQUITO ANTI-MALARIAL IMMUNE the spread of infectious diseases in most major continents, including South RESPONSE America, Asia and Africa. We are currently at the crossroads of how to reduce Win Surachetpong, Shirley Luckhart disease transmission due to environment perturbation, while at the same time enhancing the health, well-being and livelihoods of persons living in the University of California Davis, Davis, CA, United States developing world. This symposium will highlight some of the most recent data demonstrating the link between environmental change and infectious disease 11:30 a.m. transmission. Furthermore, we will explore and discuss the social impacts of this controversial issue as it relates to our changing global community. 1111 CHAIR SPATIAL REPOSITIONING OF GENE LOCI IN THE Joel M. Montgomery INTERPHASE NUCLEI OF BGE CELLS CO-CULTURED Naval Medical Research Center Detachment/Centers for Disease Control and Prevention, WITH SCHISTOSOMA MANSONI PARASITES Lima, Peru Joanna M. Bridger1, Edwin C. Odoemelan1, Halime Arican1, Ishita S. James N. Mills Mehta1, Nithya Raghavan1, Wannaporn Ittiprasert2, Andre Miller2, Matty Centers for Disease Control and Prevention, Atlanta, GA, United States Knight2 1Brunel University, Middlesex, United Kingdom, 2Biomedical Research Institute, 10:15 a.m. Rockville, MD, United States HABITAT LOSS AND PERTURBATION: THE POTENTIAL IMPACT ON INFECTIOUS DISEASE TRANSMISSION IN 11:45 a.m. SOUTHEASTERN PERU 1112 Hugo Razuri Naval Medical Research Center Detachment, Lima, Peru, United States A LATERALLY TRANSFERRED BACTERIAL 10:40 a.m. FERROCHELATASE GENE IS FUNCTIONAL IN FILARIAL PARASITES ECONOMIC STRESS, HABITAT PERTURBATION, AND LASSA VIRUS TRANSMISSION IN SIERRA LEONE, WEST Bo Wu1, Jacopo Novelli1, Daojun Jiang2, Jeremy Foster1, Peter U. Fischer2, Barton Slatko1 AFRICA 1New England Biolabs, Inc, Ipswich, MA, United States, 2Infectious Diseases Division, Daniel G. Bausch Department of Internal Medicine, Washington University School of Medicine, St. Louis, Tulane University, New Orleans, LA, United States MO, United States 11:05 a.m. HABITAT LOSS AND DISEASE TRANSMISSION IN THE AMERICAS: THE HUMAN HEALTH IMPLICATIONS Valerie Paz Soldan Tulane University, New Orleans, LA, United States 11:30 a.m. EFFECT OF LAND USE CHANGES ON MALARIA VECTOR DISTRIBUTION IN CAMBODIA Steven Tobias Naval Medical Research Unit - 2, Jakarta, Indonesia, United States

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Symposium 178 Scientifi c Session 179

Modulation of Dendritic Cell Function by Pathogens Malaria/Mosquitoes: Prevention of Transmission Delaware B Virginia AB Sunday, November 22, 10:15 a.m. - Noon Sunday, November 22, 10:15 a.m. - Noon

Dendritic cells (DC) are centrally positioned in the mammalian immune CHAIR system to orchestrate defense against infection. These cells are specialized Peter S. Larson for antigen presentation and, when combined with their ability to secrete University of Michigan, Adrian, MI, United States immunoregulatory cytokines, they play a prominent role in T cell subset differentiation and effector generation. These combined properties allow DC Fengwu Li University of California San Diego, La Jolla, CA, United States to bridge innate and adaptive immune responses. Given the importance of DC in immunity, it is interesting that many microbial pathogens actively target 10:15 a.m. these cells for infection. Furthermore, it is becoming increasingly clear that many virulent microorganisms have developed mechanisms to specifi cally disable DC function. A growing body of literature suggests that there are both 1113 common and unique methods employed by pathogens to interfere with DC function. This symposium will review recent advances in our understanding of ANOPHELES CRACENS - THE VECTOR OF THE 5TH the specifi c mechanisms used by bacteria, protozoan parasites and viruses to HUMAN MALARIA PARASITE, PLASMODIUM KNOWLESI, IN modulate DC function, resulting in establishment of persistent infection and in PENINSULAR MALAYSIA some cases development of disease. Adela Ida Jiram1, Indra Vythilingam2, Fong Mun Yik3 1Parasitology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia, 2National CHAIR Environment Agency (NEA), Singapore, 3Department of Parasitology, Faculty of Catharine M. Bosio Medicine, University Malaya, Kuala Lumpur, Malaysia National Institute of Allergy and Infectious Diseases/National Institutes of Health, Hamilton, MT, United States 10:30 a.m. Eric Y. Denkers Cornell University, Ithaca, NY, United States 1114

10:15 a.m. REGULATION OF MALARIA POPULATION DYNAMICS IN MODULATION OF HUMAN DENDRITIC CELLS BY SANTO, VANUATU VIRULENT FRANCISELLA TULARENSIS Luis F. Chaves1, Akira Kaneko2 1Emory University, Atlanta, GA, United States, 2Karolinska Institutet, Stockholm, Catharine M. Bosio Sweden National Institute of Allergy and Infectious Diseases/National Institutes of Health, Hamilton, MT, United States 10:45 a.m. 10:40 a.m. 1115 DISRUPTION OF DENDRITIC CELL AND MACROPHAGE FUNCTION DURING INTRACELLULAR TOXOPLASMA DEVELOPMENT OF A MALARIA-REFRACTORY GONDII INFECTION TRANSGENIC MOSQUITO USING AN ANTI-CHITINASE Eric Y. Denkers SINGLE-CHAIN ANTIBODY GENE Cornell University, Ithaca, NY, United States Fengwu Li1, Alison Isaacs2, Nijole Jasinskiene2, Joseph Vinetz1, Anthony A. James2 11:05 a.m. 1University of California San Diego, La Jolla, CA, United States, 2University of RESPONSES OF DIFFERENT DENDRITIC CELL California Irvine, Irvine, CA, United States SUBPOPULATIONS DURING MALARIA INFECTION (ACMCIP Abstract) Ana Rodriguez 11 a.m. New York University School of Medicine, New York, NY, United States 1116 11:30 a.m. REGULATION OF INFLUENZA VIRUS-SPECIFIC PERSPECTIVES OF PEOPLE IN MALI, WEST AFRICA TO ADAPTIVE IMMUNITY BY PULMONARY DENDRITIC GENETICALLY MODIFIED MOSQUITOES FOR MALARIA CELLS CONTROL Kevin Legge John M. Marshall1, Mahamadou B. Toure2, Mohamed M. Traore2, Shannon University of Iowa, Iowa City, IA, United States Famenini1, Charles E. Taylor1 1University of California at Los Angeles, Los Angeles, CA, United States, 2Malaria Research and Training Center, Bamako, Mali Sunday, November 22

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11:15 a.m. 10:15 a.m. VACCINES TO PREVENT PNEUMONIA AND IMPROVE 1117 CHILD SURVIVAL SPATIAL PATTERNS AND DETERMINANTS OF Richard Adegbola Medical Research Council Laboratories, Banjul, Gambia INSECTICIDE-TREATED NET USE, MALARIA AND ANEMIA IN THREE REGIONS OF MALAWI, 2005-2008 10:40 a.m. 1 2 1 Peter S. Larson , Don P. Mathanga , Mark L. Wilson ZINC AND NUTRITIONAL INTERVENTIONS TO TREAT 1University of Michigan, Ann Arbor, MI, United States, 2University of Malawi College of Medicine, Blantyre, Malawi AND PREVENT PNEUMONIA W. Abdullah Brooks 11:30 a.m. International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

1118 11:05 a.m. HANDWASHING IN THE DEVELOPING WORLD: A INSECTICIDE TREATED NETS IN MALARIA SIMPLE INTERVENTION TO PREVENT PNEUMONIA PREVENTION: DOES DISTRIBUTION MODEL MATTER? Stephen Luby Hannah Chiu, Michael Hawkes, Kevin Kain Centers for Disease Control and International Center for Diarrheal Disease Research, University of Toronto, Toronto, ON, Canada Bangladesh, Dhaka, Bangladesh 11:45 a.m. 11:30 a.m. 1119 ENVIRONMENTAL INTERVENTIONS: REDUCTION OF INDOOR AIR POLLUTION TO PREVENT PNEUMONIA EFFECTIVENESS OF INTERMITTENT PREVENTIVE Nigel Bruce TREATMENT FOR CHILDREN (IPTC) COMBINED University of Liverpool, Liverpool, United Kingdom WITH TIMELY TREATMENT AT HOME FOR MALARIA CONTROL Symposium 181 Collins S. Ahorlu1, Kwadwo A. Koram1, Atsu Seake-Kwawu2 1Noguchi Memorial Institute for Medical Research, Accra, Ghana, 2Keta District Health Advances in Anopheles gambiae Population Genomics Administration, Keta, Ghana Washington 1 Symposium 180 Sunday, November 22, 10:15 a.m. - Noon Population genomics may be defi ned as the study of genome-wide patterns of Tackling the Number One Killer of Children in the sequence variation within and between closely related species. This approach Developing World: Approaches to Prevention and can provide valuable insights into the determination of the relative importance of such evolutionary forces as mutation, recombination, natural selection and Treatment of Pneumonia genetic drift in explaining observed variation. The application of population Virginia C genomics to human biology is shedding new light on our evolutionary history and is providing the means of identifying genes that cause complex diseases. Sunday, November 22, 10:15 a.m. - Noon The release of the whole genome sequence for the malaria vector, Anopheles gambiae, in 2002 has provided vector biologists with the means of conducting In spite of the availability of cost-effective strategies to both prevent and treat population genomics studies on this species. New tools have been developed pneumonia, over 2 million children continue to die each year, which is more and studies are underway that will shed new light on the relationships among than AIDS, malaria, and measles combined. Appropriate case management divergent populations of this species and on the genetic basis of important has been shown to be highly effi cacious in treating children with pneumonia. phenotypes that infl uence malaria transmission in Africa. In this symposium However, many children in the developing world either do not seek care or we provide a description of these new methods and of the results of their do not receive appropriate antibiotics by health care workers. Pneumococcus application. and Haemophilus infl uenzae type b (Hib) together are thought to cause approximately half of childhood pneumonias. Although vaccines against both CHAIR of these organisms have been extensively used in developed countries and have had a major impact on reducing pneumonia, the majority of the poorest Gregory C. Lanzaro children in the world currently have limited access to Hib vaccine and almost University of California at Davis, Davis, CA, United States none have access to pneumococcal vaccines. Environmental and nutritional Nora Besansky factors are known to greatly increase the risk and severity of pneumonia. In University of Notre Dame, South Bend, IN, United States this symposium, world-renowned panelists will discuss the barriers to effective implementation of preventive and therapeutic strategies for pneumonia and 10:15 a.m. provide their opinions on ways to overcome these barriers. LINKAGE DISEQUILIBRIUM IN THE AN. GAMBIA CHAIR EGENOME Martin J. Donnelly Adam L. Cohen Liverpool School of Tropical Medicine, Liverpool, United Kingdom Centers for Disease Control and Prevention, Atlanta, GA, United States Mathuram Santosham Johns Hopkins School of Public Health, Baltimore, MD, United States

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10:40 a.m. 10:45 a.m. THE AN. GAMBIAE WHOLE GENOME TILING ARRAY 1122 Yoosook Lee University of California, Davis, CA, United States ENTOMOLOGICAL SURVEILLANCE FOR VIRUSES IN 11:05 a.m. THE YUCATAN PENINSULA OF MEXICO, JANUARY TO DECEMBER 2008 THE AN. GAMBIAE M AND S GENOME ANALYSIS WITH 1 2 2 A VIEW TOWARD POPULATION GENOMICS OF Bradley J. Blitvich , Maria A. Loroño-Pino , Julian E. Garcia-Rejon , Victor Soto1, Ming Lin1, Lyric C. Bartholomay1, Molly Staley1, Jose A. Farfan-Ale2 SPECIATION 1Iowa State University, Ames, IA, United States, 2Universidad Autonoma de Yucatan, Nora Besansky Merida, Mexico University of Notre Dame, Notre Dame, IN, United States 11 a.m. 11:30 a.m. DEVELOPMENT OF A GENOME-WIDE SNP ARRAY FOR 1123 AN. GAMBIAE YFV-INDUCED CYTOKINE EXPRESSION IN PRIMARY Mark A. Muskavitch HUMAN MACROPHAGES Boston College, Harvard School of Public Health, Boston, MA, United States Sara E. Woodson, Michael R. Holbrook Scientifi c Session 182 University of Texas Medical Branch, Galveston, TX, United States 11:15 a.m. Flavivirus 1124 Washington 2 Sunday, November 22, 10:15 a.m. - Noon HUMANIZED ANTI-YELLOW FEVER VIRUS MURINE MONOCLONAL ANTIBODY PROTECTS AG129 MICE CHAIR FROM PERIPHERAL VIRUS CHALLENGE Aaron C. Brault 1 2 3 Centers for Disease Control and Prevention, Fort Collins, CO, United States Brett A. Thibodeaux , John T. Roehrig , Jacob J. Schlesinger , Carol D. Blair1 Nicole Nemeth 1Colorado State University, Fort Collins, CO, United States, 2Centers for Disease Control National Wildlife Research Center, Fort Collins, CO, United States and Prevention, Fort Collins, CO, United States, 3University of Rochester Medical Center, Rochester, NY, United States 10:15 a.m. 11:30 a.m. 1120 1125 WEST NILE AND ST. LOUIS ENCEPHALITIS VIRUSES: IDENTIFICATION OF GENETIC DETERMINANTS PRE-EXISTING IMMUNITY TO RELATED FLAVIVIRUSES OF ALTERED AVIAN AND VECTOR INFECTION PROTECTS AGAINST INFECTION WITH JAPANESE PHENOTYPES ENCEPHALITIS VIRUS IN HAMSTERS Payal D. Maharaj1, Michael Anishchenko2, Stanley A. Langevin2, Aaron C. Angela M. Bosco-Lauth, Richard Bowen Brault1 Colorado State University, Fort Collins, CO, United States 1Centers for Disease Control and Prevention, Fort Collins, CO, United States, 2University of California, Davis, CA, United States 11:45 a.m.

10:30 a.m. 1126

1121 LONG-TERM IMMUNITY FOLLOWING VACCINATION WITH THE INACTIVATED JAPANESE ENCEPHALITIS NORTH AMERICAN BIRDS AS POTENTIAL AMPLIFYING VACCINE IXIARO®, IC51, AND IMMUNE RESPONSE TO A HOSTS OF JAPANESE ENCEPHALITIS VIRUS BOOSTER DOSE Nicole Nemeth1, Angela Bosco-Lauth2, Richard Bowen2 Katrin L. Dubischar-Kastner, Susanne Eder, Astrid Kaltenboeck, Christoph 1National Wildlife Research Center, Fort Collins, CO, United States, 2Colorado State Klade, Gabriele Woelfl University, Fort Collins, CO, United States Intercell AG, Vienna, Austria Sunday, November 22

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Scientifi c Session 183 11:15 a.m. 1131 Schistosomiasis and Other Trematodes - Molecular Biology/ Biochemistry PRAZIQUANTEL IS A SUBSTRATE OF A MULTIDRUG Washington 3 RESISTANCE PROTEIN (SMDR2) FROM SCHISTOSOMA Sunday, November 22, 10:15 a.m. - Noon MANSONI Ravi S. Kasinathan1, Tino Garonga2, Thomas R. Webb2, Robert M. CHAIR Greenberg1 1 2 Paul J. Brindley University of Pennsylvania, Philadelphia, PA, United States, St. Jude Children’s George Washington University Medical Center, Washington, DC, United States Research Hospital, Memphis, TN, United States Patrick Skelly 11:30 a.m. Tufts University, North Grafton, MA, United States 1132 10:15 a.m.

1127 MOLECULAR CHARACTERIZATION OF WATER MOVEMENT IN SCHISTOSOMES TRANSFORMATION OF SCHISTOSOME EGGS WITH Patrick J. Skelly, Zahra Faghiri REPORTER TRANSGENES AND MURINE LEUKEMIA Tufts University, North Grafton, MA, United States (ACMCIP Abstract) VIRUS Kristine J. Kines1, Gabriel Rinaldi1, Tunika I. Okatcha1, Maria E. Morales2, 11:45 a.m. Victoria H. Mann1, Paul J. Brindley1 1The George Washington University, Washington, DC, United States, 2Tulane 1133 University, New Orleans, LA, United States 10:30 a.m. PROTEOMIC ANALYSES OF SCHISTOSOME EGGS IN HATCHING AND DEVELOPMENT 1128 Malcolm K. Jones1, Meera Perumalpillai-McGarry1, Sujeevi Nawaratna1, Jason Mulvenna2 1 2 CHARACTERIZATION OF A MAJOR HOST-INTERACTIVE University of Queensland, Brisbane, Queensland, Australia, Queensland Institute of Medical Research, Herston Queensland, Australia SCHISTOSOME TEGUMENT PROTEIN, SM29, USING PHAGE-DISPLAYED ANTIBODIES Scientifi c Session 184 Jacque Tremblay, Jorge Sepulveda, Patrick J. Skelly, Charles B. Shoemaker Tufts Cummings School of Veterinary Medicine, North Grafton, MA, United States (ACMCIP Abstract) Global Health 10:45 a.m. Washington 4 Sunday, November 22, 10:15 a.m. - Noon 1129 CHAIR PURINERGIC SIGNALING AND IMMUNE MODULATION Ruth D. Ellis AT THE SCHISTOSOME SURFACE National Institutes of Health, Rockville, MD, United States Rita Bhardwaj, Patrick J. Skelly Antonio Quispe Tufts Cummings School of Veterinary Medicine, North Grafton, MA, United States United States Naval Medical Research Center Detachment, Lima, Peru (ACMCIP Abstract) 10:15 a.m. 11 a.m. 1134 1130 THE INTEGRATION OF NEGLECTED DISEASES: THREE RECOMBINANT EXPRESSION AND PURIFICATION OF YEARS OF EXPERIENCE IN TOGO CASPASE 9 OF OPISTHORCHIS VIVERRINI Gabriel Anthony1, Michael Deming2, Améyo M. Dorkenoo3, Kodjo Morgah3, 2 4 3 5 2 1 1 2 2 Jennifer Verani , Anders Seim , Komi Dogbe , Yao Sodahlon , Els Mathieu Sandi K. Parriott , Sutas Suttiprapa , Thewarach Laha , Banchob Sripa , 1 2 3 1 Health and Development International, Lome, Togo, Centers for Disease Control and Alex Loukas , Paul J. Brindley 3 4 1 2 Prevention, Atlanta, GA, United States, Ministry of Health, Lome, Togo, Health and The George Washington University, Washington, DC, United States, Khon Kaen 5 University, Khon Kaen, Thailand, 3Queensland Institute of Medical Research, Brisbane, Development International, Norway, Mectizan Donation Program, Atlanta, GA, United Queensland, Australia States (ACMCIP Abstract)

228 ASTMH 58th Annual Meeting www.astmh.org

10:30 a.m. 11:30 a.m.

1135 1139

THE ROLE OF PRODUCT DEVELOPMENT IS THERE AN ASSOCIATION BETWEEN PARTNERSHIPS IN R&D FOR NEGLECTED DISEASES INFRASTRUCTURE AND DISEASE REPORTING Mary Moran TIMELINESS? ASSESSMENT OF AN ELECTRONIC The George Institute for International Health, Sydney, Australia SURVEILLANCE SYSTEM OPERATING IN A RESOURCE- LIMITED SETTING 10:45 a.m. Ricardo A. Hora United States Naval Medical Research Center Detachment, Lima, Peru 1136

HYPERTENSION IN AN URBAN SLUM POPULATION: Scientifi c Session 185 POTENTIAL IMPACT OF SLUM HEALTH ON THE FORMAL HEALTH SECTOR Bacteriology - Diarrhea, Enteric Fever and Leptospirosis Alon Unger1, Ridalva D. Felzemburgh2, Vinicius B. Costa2, Astrid X. Washington 5 Melendez2, Renato B. Reis2, Francisco S. Santana2, Sharif Mohr2, Mitermayer Sunday, November 22, 10:15 a.m. - Noon G. Reis2, Lee W. Riley3, Albert I. Ko4 1 Departments of Medicine and Pediatrics, University of California, Los Angeles, Los CHAIR Angeles, CA, United States, 2Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz, Salvador, Brazil, 3School of Public Health, University of California-Berkeley, Richelle C. Charles Berkeley, CA, United States, 4Division of Infectious Diseases, Weill Medical College of Massachusetts General Hospital, Boston, MA, United States Cornell University, New York, NY, United States Eric Mintz Centers for Disease Control and Prevention, Atlanta, GA, United States 11 a.m. 10:15 a.m. 1137 1140 COMPARING THE QUALITY OF INFORMED CONSENT IN THE UNITED STATES AND MALI PROLONGED DIARRHEA IN A BRAZILIAN COMMUNITY Ruth D. Ellis1, Issaka Sagara2, Anna Durbin3, Alassane Dicko2, Donna BIRTH COHORT: EPIDEMIOLOGY, ETIOLOGIES, Shaffer3, Mark Pierce1, Louis Miller1, Mahamadoun H. Assadou2, Mamady NUTRITIONAL IMPACT AND LINKS TO PERSISTENT Kone2, Beh Kamate2, Ousmane Guindo2, Michael P. Fay4, Dapa Diallo2, DIARRHEA Ogobara K. Doumbo2, Ezekiel Emmanuel5, Joseph Millum6 Sean R. Moore1, Noélia L. Lima2, Reinaldo B. Oriá2, Relana C. Pinkerton3, 1Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Alberto M. Soares2, Richard L. Guerrant3, Aldo A. Lima2 Disease, National Institutes of Health, Rockville, MD, United States, 2Malaria 1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 2Federal Research and Training Center, Faculty of Medicine Pharmacy and Dentistry, University University of Ceará, Fortaleza, Brazil, 3University of Virginia, Charlottesville, VA, of Bamako, Bamako, Mali, 3Johns Hopkins Center for Immunization Research, United States Washington, DC, United States, 4Biostatistics Research Branch, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD, United States, 5Clinical Center Department of Bioethics, National Institutes of Health, Bethesda, 10:30 a.m. MD, United States, 6Clinical Center Department of Bioethics/Fogarty International Center, National Institutes of Health, Rockville, MD, United States 1141

11:15 a.m. MORTALITY AMONG CHILDREN WITH MODERATE-TO- SEVERE DIARRHEA IN RURAL WESTERN KENYA, 2008 1138 Richard Omore1, Ciara E. O`Reilly2, Benjamin Ochieng1, Elizabeth Blanton2, John Crump2, Tamer H. Farag3, Lynette Berkeley3, Sandra Panchalingam3, SELF-REPORTED HEALTH STATUS AND WELL-BEING James P. Nataro3, Karen Kotloff3, Myron Levine3, Fenny Moke1, Alex AMONG SMALL RIVERINE POPULATIONS IN THE Ondeng1, Peter Jaron1, Alfred Abir1, Caleb Okonji1, Michele Parsons2, Cheryl PERUVIAN RAINFOREST Bopp2, Joseph Oundo1, John Vulule4, Kubaje Adazu1, Daniel Feikin1, Kayla Laserson1, Eric Mintz2, Robert F. Breiman5 1 1 1 2 Antonio M. Quispe , Juan F. Sanchez , Angela M. Bayer , Martin Beltran , 1Kenya Medical Research Institute/United States Centers for Disease Control and 3 1 1 4 Eric S. Halsey , Victor E. Gonzaga , Hugo R. Razuri , Carol Zavaleta , Ryan Prevention, Kisumu, Kenya, 2Centers for Disease Control and Prevention, Atlanta, 1 1 1 1 C. Maves , Joel M. Montgomery , John W. Sanders , Andres G. Lescano GA, United States, 3University of Maryland, School of Medicine, Center for Vaccine 1 2 United States Naval Medical Research Center Detachment, Lima, Peru, Sub-Regional Development, Baltimore, MD, United States, 4Centre for Global Health Research, Kenya 3 Epidemiology Offi ce, Peruvian Ministry of Health, Yurimaguas, Peru, United States Air Medical Research Institute, Kisumu, Kenya, 5Kenya Medical Research Institute/ United 4 Force Wright-Patterson Medical Center, Dayton, OH, United States, National Center of States Centers for Disease Control and Prevention, Nairobi, Kenya Intercultural Health, Peruvian Ministry of Health, Lima, Peru Sunday, November 22

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10:45 a.m. 11:45 a.m.

1142 1146

OUTBREAK OF TYPHOID FEVER WITH HIGH RATE GENOMIC INSIGHTS INTO LEPTOSPIRAL OF INTESTINAL PERFORATION, KASESE DISTRICT, PATHOGENESIS UGANDA - 2008-2009 Jessica Ricaldi, Michael A. Matthias, Joseph Vinetz Karen Neil1, Samir Sodha1, Luswa Luswago2, Shikanga O-tipo3, Matthew University of California San Diego, San Diego, CA, United States Mikoleit1, Sherricka Simington1, Sam Majalija4, Atek Kagirita5, Stephen Balinandi3, Peter Mukobi6, Vianney Kweyamba7, Brigid Batten1, Patricia Symposium 186 Adem1, Deborah Talkington1, Sharif Zaki1, Eric Mintz1 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Ministry of Health, Kampala, Uganda, 3Field Epidemiology and Laboratory Training Program, Human Babesia Species: Intraerythrocytic Protozoa of Nairobi, Kenya, 4Makerere University, Kampala, Uganda, 5Central Public Health Global Public Health Concern Laboratory, Kampala, Uganda, 6District Health Offi ce, Kasese District, Uganda, 7Bwera Hospital, Bwera, Uganda Washington 6 Sunday, November 22, 10:15 p.m. - Noon 11 a.m. Babesiosis is a tick-borne disease caused by intraerythrocytic protozoan 1143 species of the genus Babesia. Human babesiosis is found throughout the world, with the highest prevalence of both tick and transfusion-transmitted infection TYPHOID FEVER OUTBREAK IN KASESE DISTRICT, occurring in the United States. Babesia microti is the most common Babesia UGANDA: 103 CASES WITH INTESTINAL PERFORATION species, causing human infection worldwide and is endemic in the northeastern and northern midwestern United States. Other Babesia species that cause 1 2 2 3 Shikanga O-tipo , Karen Neil , Samir Sodha , Luswa Luswago , Peter human disease include B. duncani and MO1 in the United States, B. divergens Mukobi4, Stephen Balinandi1, Sam Majalija5, Atek Kagirita6, Eric Mintz2 and EU1 in Europe and TW1 and KO1 in Asia. Clinical manifestations of 1Field Epidemiology and Laboratory Training Program, Nairobi, Kenya, 2Centers babesiosis range from asymptomatic infection to fulminant disease resulting for Disease Control and Prevention, Atlanta, GA, United States, 3Ministry of Health, in death. Immunocompromised individuals, including those with malignancy, Kampala, Uganda, 4District Health Offi ce, Kasese District, Uganda, 5Makerere HIV, no spleen, receiving immunosuppressive drugs and people over the University, Kampala, Uganda, 6Central Public Health Laboratory, Kampala, Uganda age of 50 years are at the highest risk of severe disease. In the majority of 11:15 a.m. healthy adults, Babesia infection results in mild to moderate symptoms that are diffi cult to distinguish from fl u-like illness. Available laboratory tests are labor- 1144 intensive and require highly specialized training and may not be well-suited for the type of mass screening necessary to identify blood donors who are γ silently infected and pose a serious blood safety risk in endemic areas. Despite EVALUATION OF INTERFERON- RESPONSES IN the signifi cant emerging global public health burden of human babesiosis, PATIENTS WITH SALMONELLA ENTERICA SEROVAR TYPHI inadequate attention has been paid to this disease that is prevalent in both BACTEREMIA IN DHAKA, BANGLADESH industrialized and developing countries. Accordingly, the primary objective of Alaullah Sheikh1, Farhana Khanam1, Taibur Rahman1, Martin Pacek2, Yanhui this symposium is to highlight the public health importance of this neglected Hu2, Andrea Baresch3, Md. Saruar Bhuiyan1, Sean Rollins3, Robert Citorik3, infection by raising awareness among researchers, heath care professionals Anuj Kalsy3, Richelle Charles3, Regina C. LaRocque3, Joshua LaBaer2, and funding agencies. Scientifi c presentations will focus on Babesia biology, Stephen B. Calderwood3, Jason B. Harris3, Firdausi Qadri1, Edward T. Ryan3 ecology, epidemiology, molecular immunology, pathogenesis, laboratory 1International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, diagnosis and blood safety concerns. 2Harvard Institute of Proteomics, Boston, MA, United States, 3Massachusetts General Hospital, Boston, MA, United States CHAIR Sanjai Kumar 11:30 a.m. Food and Drug Administration, Rockville, MD, United States 1145 Peter Krause Yale University, New Haven, CT, United States HIGH THROUGHPUT GENE EXPRESSION PROFILING 10:15 a.m. OF SALMONELLA ENTERICA SEROVAR PARATYPHI A IN THE THE BIOLOGY AND ECOLOGY OF BABESIA BLOOD OF BACTEREMIC PATIENTS IN BANGLADESH

1 2 1 1 Sam R. Telford Richelle C. Charles , Alaullah Sheikh , Sean Rollins , Jason B. Harris , Md. Tufts University, North Grafton, MA, United States Saruar Bhuiyan2, Farhana Khanam2, Archana Bukka3, Anuj Kalsy1, Steffen 4 2 1 4 Porwollik , W. Abdullah Brooks , Regina LaRocque , Michael McClelland , 10:40 a.m. Tanya Logvinenko5, Alejandro Cravioto2, Stephen B. Calderwood1, James E. Graham3, Firdausi Qadri2, Edward T. Ryan1 THE EPIDEMIOLOGY OF HUMAN BABESIOSIS 1 2 Massachusetts General Hospital, Boston, MA, United States, International Centre for Barbara L. Herwaldt 3 Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, University of Louisville, Centers for Disease Control and Prevention, Atlanta, GA, United States Louisville, KY, United States, 4Sidney Kimmel Cancer Center, San Diego, CA, United States, 5Tufts University Medical Center, Boston, MA, United States

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11:05 a.m. THE CLINICAL PRESENTATION, COMPLICATIONS, DIAGNOSIS AND TREATMENT OF HUMAN BABESIOSIS Peter J. Krause Yale University, New Haven, CT, United States 11:30 a.m. THE EMERGING RISK OF BABESIOSIS FROM TRANSFUSION IN THE UNITED STATES Jay S. Epstein Food and Drug Administration, Rockville, MD, United States

Sunday, November 22, Noon

ASTMH 58th Annual Meeting Adjourns See you next year in Atlanta, Georgia! Sunday, November 22

231 Author Index The number(s) following author name refers to abstract number.

A Aguilar, Patricia V. 647, 651, 987, Alvarado, Jessica 734 Aponte, John 160, 1070 996, 998 Alvarenga, Patricia H. 945 Appawu, Maxwell 20 A.B., Olayemi 72 Aguirre, Sarah 239 Alvares, Keith 379 Apperson, Charles S. 602 Abariga, Samuel A. 449, 454 Agunyu, Stella 818 Alvares Antonio, Carlos 23, 529 Aragon, Anthony D. 320 Abate, Luc 362 Aguwa, Okechukwu C. 197 Alvarez, Danielle 962 Arama, Charles 744 Abayneh, Sisay A. 1062 Ahmed, Jelaludin 1062 Alvarez, Leslie C. 584 Arango, Ana E. 267, 268, 987, 990 Abd El-Fattah, Mohamed E. 384 Ahmed, Tanvir 715 Alvarez, María G. 500 Araujo, Helena R. C. 755, 758 Abdel Fadeel, Moustapha 270 Ahn, Myoung-Hee 624, 625 Alvarez, Yicel 194 Araujo, Sonia 131 Abdulla, Salim M. K. 4, 664, 668, 676, Ahorlu, Collins S. K. 1119 Alves, Fabiana P. 834 Araújo, Wildo N. 308, 321 864, 1054 Aichatou, Alfari 1052 Alves, Luiz C. 755, 758 Araz, Engin 53, 628 Abdullah, Wan Ariffi n 695 Aide, Pedro 1070 Amador, Manuel 1096 Arbe-Barnes, Sarah 300, 517 Abeysinghe, Nihal 780 Aikins, Moses 819 Amadou, Konate T. 572, 899, 915, Arce, Luana 600 Abir, Alfred 1141 Ajjampur, Sitara S. R. 459 929 Ardid-Candel, Miguel 150 Aboobakar, Shahina 540 Akala, Hoseah 885 Amadou, Niangaly 566 Arenas, Fanny 264 Abot, Stephen 568, 571, 743 Akhter, Shammi 64 Amann, Josef 448 Arevalo, Jorge 127, 492 Abraham, David 312 Akhvlediani, Tamuna 773 Amarasinghe, Ananda 780 Argüello, D. Fermín 354, 439, 440, Abruquah, Harry H. 211 Akhwale, Willis 1025, 1027 Amathe, Ouedarogo 899 789 Abubucker, Sahar 118 Akinleye, Stella O. 248 Amenga Etego, Lucas 225, 669 Arguello, John J. 393, 787, 795 Abudho, Bernard 634 Akinola, Olugbenga 521 Amidou, Diarra 572, 899, 915, 929 Arguello,, Fermín Accavitti, Mary Ann 790 Ako, Berenger A. A. 526, 665, 901 Amimo, Fred A. 43 Arican, Halime 1111 Achan, Jane 366, 537 Akogbeto, Martin 1088, 223 Amnuaysirikul, Jack 297 Ariey, Frederick 2, 7, 860 Achee, Nicole 17, 242, 576, 600, 759, Aksoy, Serap 487, 488, 1012 Amoah, Linda 530 Arinaitwe, Emmanuel 663 967, 970, 973, 975, 1092 Al Saffar, Abrar 60 Ampofo, William K. 729 Arlian, Larry G., 753 Achilla, Rachel 733 Al-Ali, Faiza 60 Ampuero, Julia 832 Arman, Shaila 725 Acosta, Colleen 260, 605 Al-Enezy, Nadia A. 60 Amusugut, T. 487 Armbruster, Peter 15 Acosta, Heidi 440 Al-Mekhlafi , Hesham M. S. 695 Amuzu, Hilaria 245 Armel, Djenontin 1087 Acosta, Luz 440 Alaba, Olufunke A. 226 Amwayi, Samuel 294 Armenti, Alejandro H. 500 Acosta, Luis 79 Alabaster, Amy 949 Ancca Juárez, Jenny 484 Armoo, Samuel 210 Acosta, Luz P. 379, 462, 99 Alam, Md Tauqeer 2 Anders, Robin F. 1037, 1076, 564, Armstrong, Adam 712 Acosta, Norma 312 Alam, Masud 315 847, 919 Armstrong, Gregory 645 Acurio, Margoth 606 Alam, Murshid 715 Andersen, John F. 945 Armstrong, Philip M. 388, 389 Adam, Ishag 175 Alam, Mohammad S. 835 Anderson, Jennifer M. 11, 481, 845, Armstrong, Tanya 751 Adama, Gansane 572, 915, 929 Alarcon, Maritza 131, 498, 827 961, 1039, Arnaud-Barbe, Nadège 394 Adamani, William 453, 640 Alava, Araceli 995 Anderson, Justin R. 257, 577 Aroian, Raffi V. 468 Adams, A.P. 689 Albareda, María C. 500 Anderson, Sheri L. 233, 390, 391 Arrigo, Nicole 1004, 689 Adams, David 503 Albuquerque, Maria Juliana 989 Anderson, Tim 532, 533 Asahi, Hiroko 144, 182 Adams, John H. 336, 519, 527 Alcantara-Neves, Neuza 452 Andrade, Luiza F. 274 Asamoah, Rebecca 77 Adams, Matthew 897 Alecrim, Maria das Graças 335 Andre Lin, Ouedraogo 915 Asencios, Luis 606 Adams, Yvonne 150 Alefantis, Timothy 936 Andreadis, Theodore G. 16, 388, 389, Asfoor, Fetouh 60 Adazu, Kubaje 1141 Alegana, Victor A. 1028 591 Ashar, Raj 111 Adda, Christopher G. 847 Alegre, Yuri 227 Andrew, Coley 919 Asher, Constance 883 Addo, Rachel 147 Aleman, Washington 990 Andrews, Katherine T. 158, 299 Ashley, Elizabeth 26 Adem, Patricia 1142 Alera, Maria Theresa P. 799, 810 Andrews, Phyllis 770 Ashorn, Per 865 Adema, C.M. 699 Alexander, Mathew 668 Andze, Gervais O. 1023 Ashour, Ameen 670 Ademowo, George O. 138, 850 Alexander, Neal 680 Angelino, Elaine 378 Aslanova, Afag 1001, 451 Ademowo, Olusegun G. 501 Alexanian, Aline 940 Anglero, Yesseinia I. 429 Asmah, Richard H. 913 Adesiyun, Abiodun 607, 689 Alfaro, Manuel 474 Angles, Rene 702 Asnis, Deborah 266, 986, 991 Adhin, Malti 860 Alfred, Tiono 572, 899, 903, 915, 929 Angov, Evelina 902, 933, 935, 936, Asoala, Victor 549, 669 Adimi, Farida 195, 265 Alheri, David 453 937, 938, 940 Assadou, Mahamadoun H. 1137, 541, Adjei, Ohene 1102 Ali, Mohamed A. R. 384 Angulo-Barturen, Inigo 160 552 Adjemian, Jennifer A. 726 Alioni, V. 487 Anishchenko, Michael 1120 Assis, Dalva M. 308 Adjuik, Martin 225, 549, 669 Aliota, Matthew T. 235 Aniya, Charmaine 1068 Astete, Helvio 352, 586 Adoke, Yeka 25 Alisjahbana, Bachti 1104 Anova, Lalaine 883 Atibu, Jef 224 Adroher, Francisco Javier 463 Allain, Theresa J. 327 Ansah, Patrick 225, 669 Atkinson, Barry 809 Adupko, Selorme 913 Allan, Richard 547, 870 Ansari, Aftab A. 90, 441 Atuguba, Frank 225, 549, 669 Aebig, Joan A. 939, 1075, 565 Allan, Sandra A. 581 Anstead, Gregory M. 480 Aucott, John 415 Afrane, Yaw 220, 258, 679 Allen, Lee-Ann H. 660 Anstey, Nicholas M. 137 Auguste, Auguste J. 689 Afsar, Aram 1032 Allende, Ivan 996 Anthony, Gabriel 1134 Auliff, Alyson M. 527 Agbenohevi, Prince 270, 767 Allicock, Orchid 424 Antonelli, Lis R. V. 37 Aure, Wilfredo E. 87 Agbenyega, Edward T. 211 Almeida, Giulliana T. 319, 643 Antonio-Nkondjio, Christophe 575, Austin, Christopher 888 Ager, Arba 295, 833 Alonso, Pedro 160, 1070 720, 966 Avšič-Županc, Tatjana 286 Aggarwal, Nitin 462 Alpha, Adamou 588 Anum, Dorothy 914 Avelar, Lívia 274, 283 Agola, Eric L. 1049 Alphey, Luke 358, 359, 580, 967 Anuradha, R. 1085 Avilés, William 94, 96 Agrawal, Dinesh 157 Alphonse, Ouedraogo 572, 899, 903, Anyamba, Assaf 578, 652, 717 Avril, Marion 910 Agtini, Magdarina 76 915, 929 Anyan, William K. 182, 380 Awaldad, Razia 102 Aguayo, Nicolas 267, 268, 768, 990, Altcheh, Jaime 834 Anyirekun Fabrice, Some 377 Awobode, Henrietta O. 191 996 Altmeyer, Ralf 333 Anyona, Samuel B. 140, 141, 142, Ay, Hakan 53 Agudelo, Olga 206 Alumasa, John N. 511 553, 555, 556, 557, 742 Ayad, Mohamed 1026 Agudo, Roberto 267, 268, 653 Alvar, Jorge 830 Anyonje, Elizabeth 544 Ayala, Diego 720 Aguiar, Joao 568, 1009 Alvarado, Arturo 942 Anyorigiya, Thomas 225, 549, 669 Aydin, Ali 628

232 Author Index The number(s) following author name refers to abstract number.

Ayede, Adejumoke I. 851 Barboza, Alma 267, 268, 996 Beekwilder, Jules 513 Bhuiyan, Md. Saruar 1144, 1145 Ayeh-Kumi, Patrick 84, 913 Barcinski, Marcello 662 Beerntsen, Brenda 213 Bian, Guowu 364 Ayi, Kodjo 343, 848, 877 Barclay, Victoria C. 564 Beeson, James G. 318, 542, 910, Bickersmith, Sara 718 Ayieko, Cyrus 203 Bardhan, Pradip K. 1103 911, 1069, 1071, 1076 Bienvenu, Anne-Lise 153, 27 Ayisi, John 917 Baresch, Andrea 1144 Beg, Mohammed Asim 176, 177, Bigira, Victor 663 Ayuk, Mary A. 637 Barger, Breanna 149 183 Bila Traore, Oumar 149 Ayyash, Luma A. 602 Bargues, Maria Dolores 702 Begum, Nur Hur 64 Bilak, Hana 538 Azab, Adel 649 Baric, Ralph 779, 790 Begum, Yasmin Ara 715 Billingsley, Peter 897 Azabo, R. 487 Barillas Mury, Carolina 237, 595 Bei, Amy 1147 Bimi, Langbong 539, 819 Azad, S.M. Shamim. 288 Barker, Christopher M. 980 Beier, John C. 433 Bingham, Georgina V. 582 Azizan, Azliyati 42, 892 Barker, Robert H., Jr. 166, 169, 518 Beingolea, Luis 995 Binh, Vu Quoc 152 Barletta, Francesca 713 Belicha-Villanueva, Alan 788 Birnberg, Lotty 718 B Barnadas, Celine 24, 375 Bell, Andrew 981 Birren, Bruce 351, 378 Barnafo, Emma 939 Bell, David 860 Bischoff, Emmanuel 927 Baah, Eugene 913 Barnes, Kayla 378 Bell, Jeffery A. 256 Bishop, David 1053 Baba, Abubakar 259 Barnes, Karen I. 26 Bellinger, David C. 99 Bishop, Henry 56, 313, 466, 627 Babadjanov, A.K. 403, 404 Barnett, Adrian 1046 Belmonte, Maria 571, 743 Bisio, Margarita 38 Babaria, Palav 738 Barnett, Elizabeth D. 650, 997 Beltramello, Martina 422 Bissek, Anne-Cécile Z. 328 Baber, Ibrahima 598 Barnwell, John 2, 3, 860 Beltran, Martin 445, 446, 1138 Bissinger, Brooke W. 48 Babu, Subash 1085 Barón, Clemencia 504 Beltran, Manuela 440 Björkman, Anders 178 Babuadze, Giorgi 754 Barr, John R. 495 Beltran, Sophie 280 Black, Carla L. 381 Bacchi, Cyrus 132, 748, 829 Barrantes, Melvin 267, 268, 990 Beltrán-Alzate, Camilo 604 Black, Gavin 880, 881 Bacellar, Olivia 831 Barrera, Roberto 1096 Bendezu, Jorge 376, 558, 923 Black, IV, William 358, 583, 1091 Bacon, David J. 23, 529, 554, 925, Barreto, Mauricio L. 452 Benenson, Jon D. 796 Blair, Carol D. 1124, 785 942 Barry, Abdoulaye 27 Benítez, Rocío 463 Blair, Lynsey 823 Bagayoko, Mamadou W. 772 Barry, Amadou 856 Benitez, Susana 467 Blair, Patrick J. 420 Bagirov, Sadigulla 1001, 451 Bartholomay, Lyric 483, 1122 Bennett, Adam 601 Blaise, Karibushi 609, 705 Bahia, Maria Terezinha 746 Bartlett, John A. 365, 472 Bennett, Kent 298, 884 Blaney, Joseph E. 396 Baia, Kay 1022 Barvir, David A. 786 Bennett, Shannon N. 424, 686, 88 Blanford, Simon 1089, 981 Baia, Manasseh 1022 Baryner-Santos, Fabio A. 758 Bennuru, Sasisekhar 672, 820 Blanton, Elizabeth 1141 Bailey, Jason 117 Bashir, Nasira H. 102 Benoit, Christine 650 Blatz, Peter J. 611, 612 Baird, Kevin 185 Bashir, Sahar 175 Benoit, Joshua 15 Blaylock, Jason M. 426 Baisor, Moses 1022 Basile, Kamgang 719 Berenzon, Dmitri 739 Blazes, David 111 Bajenov, Leonid G. 403, 404 Bastos, Cecilia M. 166 Berger, Jacques 145 Blitvich, Bradley J. 1122, 644 Bakare, Rasheed A. 259 Bastos, Maria de Loudes S. 989 Bergmann-Leitner, Elke S. 902, Bloland, Peter B. 4 Baker, Joanne T. 860 Basu, Saikat 774 935, 936, 937, 938 Blyn, Larry 811 Baker, Robert J. 809 Batchelor, Adrian 1037 Berkeley, Lynette 1141 Boakye, Daniel A. 20, 245, 819 Baker, Samuel 222, 546, 678 Bathurst, Ian 298 Bermingham, Eldredge 718 Bocángel, César D. 484 Bakhishova, Sevinj 1001, 451 Batomen, Francis 575 Bern, Caryn 484 Boddey, Justin 1154 Bakke, Brock 992 Batsa, Linda 1102 Bernabe, Antonio 736 Bodeau-Livinec, Florence 145 Balachandran, Harikrishnan 569 Batten, Brigid 1142 Bernal, Jaime M. 923 Bodhidatta, Ladaporn 711 Balasegaram, Manica 830 Batty, Kevin T. 508, 510 Bernal, Maria 657, 713, 768, 78 Bodinayake, Champika 775 Baldacci, Patricia 927 Bauer, Kristen 426 Bernal-Rubio, Dabeiba 788 Boelaert, Marleen 830 Baldet, Thierry 1088, 573 Bausch, Daniel G. 1065, 727 Bernard, Kristen A. 1095 Boggiatto, Paola 483 Baldi, Pierre 1007 Baxter, Michael C. 874 Berns, Abby L. 309 Boissier, Jérôme 280 Baldwin, Carson D. 811 Bayat, Babak 1032 Berrada, Zenda L. 13 Boisson, Bertrand 927 Baldwin, Mathew 261, 605 Bayer, Angela M. 1138, 445, 446 Berrang Ford, Lea 187 Boivin, Michael J. 345, 849 Bales, Amber A. 257 Baylink, David 379 Bertaux, Lionel 7 Bojang, Kalifa A. 509 Balinandi, Stephen 1142, 1143 Bayoh, Nabie 1027 Bertocchi, Graciela 500 Bokhari, Abdullah A. B. 340 Ballou, Ripley 1010 Bazan, Isabel 654 Berzosa, Pedro 335 Bolton, Jessica 1009 Balmaseda, Angel 285, 351, 423, Bazzocchi, Chiara 1101 Besansky, Nora J. 961, 964 Bond, Vincent 741 94, 96 Be-Barragan, Leobardo 21 Besirbellioglu, Bulent 53 Bongfen, Silayuv E. 877 Balogun, Sulayman T. 855 Beane, Jennifer E. 1094 Bessoff, Kovi 1096 Bonizzoni, Mariangela 220 Balu, Bharath 519 Bear, Allyson P. 735 Best, Wayne M. 751 Boodoo, Richard 833 Bamani, Sanoussi 710 Bear, Kelly A. 306 Bethell, Delia 22, 858, 896, 907, Booker, Michael 166, 169 Bamba, Karidiatou 27 Beard, Raphaelle H. 1097 1079 Boonmar, Sumalee 615, 993 Bamba, Sory I. 710 Beare, Nicholas A. V. 1041, 135 Beutels, Philippe 399 Boonnak, Kobporn 33, 430 Banania, Glena 571, 743 Beatty, Mark E. 399, 794, 797, 800, Beverley, Stephen M. 125 Bopp, Cheryl 1141 Bandea, Rebecca 466, 621 801 Bhandari, Janhavi 170 Borboa, Rachel 507 Bang, Gilles 1076 Beatty, P. Robert 356, 422, 428 Bhandary, Sangita 57 Borghini-Fuhrer, Isabelle 300, 517 Bangirana, Paul 345, 863 Beaty, Barry J. 596 Bhardwaj, Rita 1129 Bosch, Irene 427 Bangura, James J. 1065, 727 Beaudet, Beth 748 Bharti, Ajay R. 861 Bosco-Lauth, Angela M. 1121, 1125 Banu, Nuzhat N. 324 Beavogui Ah, Abdoul H. 208 Bharti, Nita 325 Bose, Anindya S. 804 Banura, Patrick 322, 471 Beck, Hans Peter 853, 854 Bharti, Praveen 904 Bose, Carl 224 Bar, Anindita 482 Becker, Stephen 694 Bhat, Sajid Q. 1085 Bosio, Christopher F. 418 Barata, Lídia 490 Beckius, Miriam L. 611 Bhattarai, Achuyt 1062 Bosompem, Kwabena M. 314, 380 Barban, Veronique 394 Bedi, Gurpreet K. 769 Bhavnani, Darlene 656 Bosque-Oliva, Elisa 704 Barbara, Katie A. 420 Bedno, Sheryl 885 Bheecarry, Ambicadutt 540 Bossin, Herve 1019 Barbosa-Cabrera, Elizabeth 620 Beebe, Nigel W. 255 Bhonsle, Jayendra B. 168, 873 Bouchier, Christiane 335 Barbour, Alan G. 9 Beech, Camilla 967 Bhuiyan, Abu T. 835 Boudko, Dmitri Y. 954

233 Author Index The number(s) following author name refers to abstract number.

Bougouma, , Edith C. 932, 934 Bulimo, Wallace 733 Carpenter, Rand 417 Charman, Susan 751 Bouillet, Erica M. 200 Bull, Peter C. 1069 Carpenter, Tim 690 Charmoy, Melanie 1150 Bounkeua, Viengngeun 317 Bungiro, Richard D. 314 Carrasquilla, Gabriel 504 Charunwatthana, Prakaykaew 135 Bourguinat, Catherine 120 Burch, Christina 852 Carreira, Carlos A. 989 Chase, Amanda J. 34 Boussinesq, Michel 120, 328 Burga, Rosa 768, 79 Carrera, Juan P. 809 Chatterjee, Arnab K. 170, 507 Bouwmeester, Harro 513 Burgess, Steven J. 876 Carrera, Silvia 260 Chatterjee, Mitali 36 Bovill, Maria 544 Burgess, Timothy H. 1104 Carrier, Elizabeth T. 87 Chauca, Gloria 987, 990 Bowen, Richard 393, 795, 1121, 1125 Burgos, Juan M. 38 Carrington, Christine V. F. 424, 689 Chauhan, Chitra 121 Bowler, Kate 1053 Burk, Chad R. 1007 Carrington, Mary 917 Chauhan, Virander 1070 Bowling, Tana 132, 748 Burke, Donald S. 32 Carrion, Gladys 474 Chaussabel, Damien 1081 Bowman, Dwight D. 692 Burkhard, Peter 1034 Carrion, Rebeca 654 Chavchich, Marina 6 Boyle, Glen 158 Burkot, Thomas 589 Carroll, Dustin 873, 880, 881, 883 Chaves, Luis F. 1114, 254, 589 Boyle, Katharine 936 Busche, Jeff 953 Carroll, Karen C. 682, 869 Che, Pulin 167 Boyle, Michelle 1076, 318 Bustos, Javier A. 311 Carter, Jennifer 940 Cheah, Phaik Y. 165 Bozdech, Zbyneck 158 Butler, Sara E. 634 Carter, Jennifer M. 381 Chen, Chang-Shi 468 Brackney, Doug E. 1094 Butrapet, Siritorn 393, 785 Carvajal, Daisy 238, 601 Chen, Daitao 132, 748, 829 Bradley, Mark 709 Büttner, Dietrich W. 824 Carvalho, Eunice B. 81 Chen, Honggen 1046 Braga, Erika M. 200 Buzzanell, Patrice M. 457 Carvalho, Edgar M. 37, 831, 832, 989 Chen, Hua-Wei 14, 608 Bralove, Benjamin R. 692 Bwire, Godfrey S. 726 Carvalho, Leonardo J. M. 843 Chen, I-Tzu 402 Branch, OraLee 559, 904, 905, 920, Byamukama, Edson 818 Carvalho, Omar S. 276 Chen, Iris 69 943, Byarugaba, Justus 863 Casapia, Martin 187 Chen, Junhu 867 Brando, Clara 1034 Byrd, Brian D. 52, 54 Casares, Sofi a 570 Chen, Kow-Tong 411 Brant, Sara V. 1049, 703 Bythwood, Tammiki 916 Castaneda, Lisa J. 170 Chen, Lin 650, 997 Brattig, Norbert W. 674, 814, 824 Byus, Craig V. 661 Castillo, Roger 653 Chen, Li 766 Brault, Aaron C. 1120 Castillo Neyra, Ricardo 484 Chen, Nanhua 534, 6, 860 Brawn, Jeffrey 599 C Castineiras, Catarina 193 Chen, Song 363 Brayner-Santos, Fabio A. 755 Castro, Fanny 759 Chen, Wei-June 234, 805, 807 Breiman, Robert Cabezas, Cesar 23 Castro, Julia 520 Chen, Xiaochun 151 Breiman, Robert F. 73, 85, 294, 652, Cabrales, Pedro 843 Castro, Martha I. 958 Chen, Yun-Chi 1006 1141, Cabrera, Lilia 658, 736 Castro-Jorge, Luiza A. 434, 781 Chen, Zhong 507 Breininger, Irena 809 Cabrera, Mynthia 525 Castro-Llanos, Fanny 975 Chenault, Michelle V. 1016 Breman, Joel G. 1057 Cabrera Champe, Rufi no 478 Catherine, Blanc 560 Chenet, Stella M. 554 Brems, Robert 56 Caceda, E. R. 998 Cator, Lauren J. 1017, 590 Cheng, Jiping 157 Brengues, Cécile 957 Cacho, Jorge 923 Cauwenbergh, Sarah 988 Cheng, Min-Lee 388 Brettin, Thomas S. 414, 616 Caci, Jennifer B. 784 Cavallaro, Kathleen F. 443 Cheng, Qin 28, 527, 534, 6, 860, 891, Brewoo, Joseph N. 393, 787, 791, 992 Cajal, Silvana 312 Caviedes, Lucy 734 892 Breysse, Patrick 691 Calderón-Squiabro, José M. 439, 789 Caviedes, Luz 736 Chenine, Agnes L. 475 Briand, Valerie 145 Calderwood, Stephen B. 1144, 1145, Cecile, Brengues 719 Chesson, Joanne 910, 1069 Briceno, Marnie 665, 901 323, 715, 716 Celatka, Cassandra 166 Cheung, Kong 230, 956 Bridger, Joanna M. 1111 Calvert, Amanda 785 Cepeda, David 713, 768, 78, 79 Chicaiza, Wilson 267, 268, 990 Bridges, Michael A. 1064 Calvo, Eric 945 Cerutti, Maria Chiara 1101 Chichester, Jessica 41, 1038 Brien, James D. 95 Cama, Vitaliano A. 658 Cespedes, Manuel 647 Chico, Martha E. 467 Briggs, Benjamin J. 809 Camacho, Daria 427, 995 Cevallos, William 656 Chidiebere, Njoku 1021 Brightsmith, Donald 292 Cammack, Nick 35 Chabbi, Joseph 1088 Childs, James E. 591 Brindley, Paul J. 1127, 1130, 637 Campbell, Christopher O. 519 Chabi, J. 223 Chimma, Pattamawan 205 Brinker, Achim 170 Campo, Joe 160 Chadee, Dave 101, 607, 689 Ching, Wei-Mei 14, 608 Briolant, Sébastien 7 Campos-Rodríguez, Rafael 620 Chai, Jong-Yil 623, 626, 632 Chinh, Nguyen Trong 152 Britch, Seth C. 578, 652 Canal, Enrique 78 Chai, Wengang 318 Chiodini, Peter L. 1050 Broadwater, Anne 31, 775, 783 Cano, Patricia 440 Chaichana, Panjaporn 179, 896 Chiosis, Gabriela 159 Brockley, Sarah 565 Cantey, Paul T. 1020, 329 Chakraborty, Debasrita 614 Chippaux, Jean-Philippe F. 130 Broncano, Nely 467 Cantilena, Louis R. 67 Chakravarty, Sumana 897, 941 Chiroque, Juan F. 311 Brooker, Simon 106, 458 Cao, Jun 372, 867 Chamnanchanunt, Supat 470 Chisenhall, Daniel M. 978 Brooks, Janna 448 Cao, Wu-Chun 731 Chams, Linda M. 65 Chishimba, Sandra 543 Brooks, W. Abdullah 1145 Cao-Lormeau, Van-Mai 30 Chan, Brian H. K. 564, 893 Chisti, Mohammad J. 1103 Broutin, Helene 325 Capeding, Maria R. Z. 87, 395 Chand, Meera A. 1050 Chitnis, Chetan E. 911, 1070 Brown, Allison C. 347 Cappai, Roberto 847 Chanda, Pascalina 732 Chiu, Hannah 1118 Brown, Charles 539, 819, 913 Capparelli, Edmund 224 Chandre, Fabrice 1088, 1090, 223 Chizema-Kawesha, Elizabeth 866 Bruce, David C. 414, 616 Cappello, Michael 314 Chang, Gwong-Jeng 92 Chluaydumrong, Amporn 1032 Bruder, Joseph T. 570, 743, 1078 Carapau, Daniel 1035 Chang, Shing 746 Cho, Kyou-Nam 694 Bruhn, Kevin 494 Cardona-Castro, Nora M. 604 Chang, Sandra P. 563 Cho, Shin Hyung Cho 926 Bruna-Romero, Oscar 200 Cardoso, Alessandra V. 308 Chang, Wonsuk 151 Choi, Han-Kyu 624, 625 Brunetti, Enrico 1101 Cargo, John 570 Chang, Yu-Wei 411 Choi, Kyung Mi 926 Brutus, Laurent 130, 834 Carhuas, Cinthia M. 445 Chanthavanich, Pornthep 436 Choi, Yien Kyoung 926 Buathong, Nillawan 907 Caridha, Diana P. 873 Chao, Chien-Chung 14, 608 Chokejindachai, Watcharee 1071 Buchholz, Arlene 313 Carlson, Misty 750 Chao, Day-Yu 802, 92 Chokephaibulkit, Kulkanya 90 Büchter, Britta 72 Carlsson, Hans Erik 279 Chappuis, François 747 Chokheli, Maiko 773 Buckeridge, David L. 187 Carlton, Elizabeth J. 1048, 641, 642 Chareonviriyaphap, Theeraphap 17, Chotmongkol, Verajit 409 Buczak, Anna L. 717 Carmo, Eduardo H. 308 242, 970, 973, 982, 1092 Chowdhury, Anwarul Haque 443 Bueno, Lilian L. 200 Carn, Gwenaelle 301 Charlebois, Edwin 366 Chowdhury, Fahima 323, 715, 716 Bukka, Archana 1145 Carnevale, Pierre 223 Charles, Richelle 1144, 1145 Chowdhury, Shamsi A. 324

234 Author Index The number(s) following author name refers to abstract number.

Chretien, Jean-Paul 652, 717 Cooper, Philip 452, 467 Cunningham, Coleen K. 472 Dayan, Gustavo 439, 442, 789 Christensen, Bruce 123, 235 Cooper, Robert D. 255 Cuong, Bui Tri 152 de Almeida, Marcos E. 134 Christian, Roussilhon 560 Cooperband, Miriam F. 581 Cupit, Pauline M. 320 de Alwis, Adamberage R. 31 Christofferson, Rebecca C. 983 Corby-Harris, Vanessa 951, 952 Cupp, Ed 1024 de La Rocque, Stephan 652 Christova, Iva 648 Cordeiro, Carlos 490 Cura, Carolina 38 de Montenegro, Ana L. 760 Chua, Aileen 297 Cordón-Rosales, Celia 760 Currie, Bart 8 De Rivera, Ivette 267, 268 Chuang, Ching-Kai 805, 807 Cordova, Juliana 264 Curtis, Kurt C. 814 de Silva, Aravinda M. 31, 422, 775, Chuang, I 1078 Corine, Demanga G. 560 Custer, Jerome 569, 1033 779, 780, 783, 790 Chuang, Ilin 1079 Cornejo del Carpio, Juan G. 484 Cutrera, Ana P. 756 de Silva, Dharshan 780 Chuang, Shu-Fang 802 Correa, Margarita 718, 722, 958, Czechowski, Donna M. 809 de Silva, Thilini 780 Chudy-Onwugaje, Kenechukwu 965 Czesny, Beata 879 De Smet, Martin 222, 678 O. 217 Corrêa-Oliveira, Rodrigo 275, 382 De Sousa, Alexandra 1056, 506, 856 Chukwuocha, Uchechukwu M. 197 Cortes-Guzman, Antonio J. 644 D de Vlas, Sake J. 328, 731 Chung, Dong Hoon 813 Cortese, Joseph 166, 169, 378, 536, Debrah, Alexander Y. 1102 Ciccotosto, Giuseppe D. 847 878 D’Alessandro, Umberto 376, 558 Dejli, Jamal 767 Cieza, Roberto 474 Cortez, Ricardo 977 D’Ambrozio, Jonathan 902 Dejsirilert, Surang 615, 993 Cisse, Moussa B. M.. 1088 Coscaron-Arias, Cecilia 967 D’Amico, Valeria 1101 Del Cuadro, Daniel 227 Cisse, Ousmane H. 1043 Cosseau, Céline 280 D’Alessandro, Umberto 25 Delgado, Stephen 484 Cistero, Pau 1070 Costa, Lourrany B. 75 da Costa, Gonçalo 490 Delroux, Karine 241 Citorik, Robert 1144, 610 Costa, Ligia M. C. 308 da Costa, Giovani C. V. 495 DelVecchio, Vito 936 Cjuno, Alfredo 311 Costa, Vinicius B. A. 1136 da Silva, Alexandre J. 134, 313, DeMarco, Ricardo 319 Claps, Guillermo L. 960 Costantini, Carlo 252, 575 466, 56, 621, 627 Dembele, Benoit 1081, 1083, 1084, Clardy, Jon 169, 536, 878 Cot, Michel 145 da Silva-Pereira, Rosiane 275 113, 332 Clark, Ben 68 Coudeville, Laurent 398, 399, 442 Dabire, Roch 1090, 573 Dembele, Demba 172 Clark, Danielle V. 1001, 451, 773 Coulibaly, Cheick Amadou 481 Dabire, Roch K. 252 Deming, Michael 1134 Clark, Eva 920 Coulibaly, Drissa 1074, 566 Dabo, Abdoulaye 744 Deng, Haiyan 875, 889 Clark, Gary G. 1093, 581 Coulibaly, Mamadi 727 Dabod, Elijah 1071, 911 Denise, Mupfasoni 609, 705 Clark, Jeffrey W. 578 Coulibaly, Mamadou B. 961 Daboi, Jerry 727 Denlinger, David L. 15 Clark, Tamara D. 1066, 537 Coulibaly, Michel E. 1081, 1083, Dada-Adegbola, H 850 Dent, Arlene 368, 918 Clayton, Joshua 1037, 940 1084, 113, 332 Dadhich, Swati 36 Deolindo, Poliana 662 Cleary, Lynn 107 Coulibaly, Oumar M. 856 Dagostino, Eleanor F. 170 deOliveira, Ana 675 Cleaveland, Sarah 447 Coulibaly, Siaka Y. 1081, 1083, Dai, Bui 152 DePasse, Jay 673 Clemens, Emily G. 682, 869 1084, 113, 332 Dai, Weili 561 DeRisi, Joseph L. 285 Clements, Archie 106, 458, 190 Coulibaly, Yaya I. 1083, 1084, 113, Daily, Johanna 841 Deriso, Elizabeth 936 Clements, David 1068 332 Dama, Souleymane 172 Dervaux, Benoit 399 Clowes, Petra 860 Counihan, Helen Counihan 71 Dambach, Kaitlyn M. 33 Desai, Anita 443, 804 Cobblah, Millicent 20 Cousin, Marc 853, 854 Damon, Inger 289 Desai, Meghna 666, 900 Coberly, Jacqueline 1005 Coutinho, Hannah M. 379, 462 Daniel, Dodoo 915 Desai, Sanjay A. 1108, 147, 337, 340 Cockburn, Ian A. 1006 Cowman, Alan F. 1069, 1071, 911 Daniell, Cyndy 621 Desbordes, Marc 1059 Coffeng, Luc E. 328 Coyle, Christina M. 770 Daniels, Rachel 378 Desewu, Kwame 20 Coffey, Lark L. 688 Craft, Carl 298, 300, 517 Danso-Appiah, Anthony 633 Desir, Luccene 708 Cohan, Deborah 537 Craft, Noah 494 Dantur Juri, María J. 722, 960 Desire, Kargougou W. 572 Cohen, Adam L. 735 Craig, Philip S. 55 Dao, Adama 588 Desruisseaux, Mahalia S. 496 Cohen, Danielle B. 327 Crandall, Ian E. 514, 516 Daou, Modibo 1074, 744 Dessis, Damien 399 Cohen, Joe 1010, 1032, 1074 Cravioto, Alejandro 1145 Dara, Antoine 1042, 149, 208 Detter, J. Chris 414, 616 Cohen, Justin M. 1053 Cravo, Pedro 335 Darapiseth, Sea 22, 858, 896 Devasiri, Vasantha 775 Cohen, Sara 761 Crevat, Denis 395 Darley, Sarah R. 1057 Deveci, Mustafa 53 Cohuet, Anna 362, 720, 723 Crisanti, Andrea 1034 Das, Debasheesh 523 Devine, Gregor J. 227, 576 Colborn, James M. 1043 Crivat, Georgeta 840 Das, Pradeep 762, 763 Dewa, Priscillia 105, 444 Coldren, Rodney L. 885 Crockett, Maryanne 985 Das, Satadal 482, 614, 774 Deye, Gregory 550, 884 Coleman, Michael 221 Crompton, Peter D. 1007 Dasch, Gregory A. 414, 616 Dhakhwa, Jyoti R. 711 Coleman, Russell E. 386, 757 Cropp, Bruce 91, 950 Dash, Aditya P. 171, 666, 900 Dharia, Neekesh V. 5 Colley, Daniel G. 381, 634 Crosby, Seth D. 124 Daszak, Peter 1100 Dhillon, GPS 804 Colley, Gretchen 500 Cross, Nadia 1076 Datagni, Gbati 112, 114 Dhorda, Mehul 26 Collins, Frank H. 964 Crowther, Gregory J. 170 Dave, Kirti 386, 757 Diabate, Abdoulaye 252, 573 Collins, Katharine 1077 Crump, John 1141 Dave, Sonia 386 Diagana, Thierry 507 Colloca, Stefano 1077 Crump, John A. 365, 472 Davenport, Gregory C. 140, 141, Diakité, Mahamadou 598, 845, 1039 Comach, Guillermo 267, 268, 427, Cruz, Ashley 348 142, 553, 555, 556, 557, 742 Diakité, Seidina A. 303, 845, 1039 990, 995 Cruz, Alvaro 452 David, Consuelo Veronica G. 494 Diallo, Abdoulbaki 541, 856 Comrie, Andrew 484 Cruz, Cristhopher 653, 995, 996 David, Denlinger L. 236 Diallo, Abdallah A. 113, 332, 1081, Conn, Jan E Cruz, Estrella I. E. 87 David, Kangoye T. 572 1083, 1084 Conn, Jan E. 718, 722, 958, 960, Cserti-Gazdewich, Christine M. 343 David, Mariana R. 251 Diallo, Brehima 961 963, 965 Cuervo, Andres 228 Davies, Stephen J. 284, 447, 638 Diallo, Daouda 481 Connors, Katherine J. 1017 Cumberbatch, Anton 607 Davis, Stephen 447 Diallo, Dapa A. 541, 552, 1074, Conrad, Patricia A. 690 Cummings, Derek A. T. 32, 353, Davis, Timothy M. E. 510, 862 1083, 1137 Conroy, Andrea 1044, 1045 796 Dawam, Jacob A. 302 Diallo, Moussa 588, 972 Contreras, Juan 922 Cummings, James 1079, 550 Dawson-Hahn, Elizabeth 107 Diallo, M’Bouye 598 Conway, David 509 Cummings, Richard D. 636 Day, Jonathan F. 390 Diallo, Souleymane 62, 63 Cook, Joseph A. 686 Cummings, Robert F. 388 Day, Karen P. 145 Diamond, Michael S. 95 Coomes, Oliver T. 187 Cunningham, Charles 320 Day, Nicholas P. J. 135, 137, 523 Diarra, Amidou 932, 934

235 Author Index The number(s) following author name refers to abstract number.

Diarra, Elisabeth 27 Doranz, Benjamin J. 431 Eavey, Allison 331 Ernst, Kacey C. 1031, 906 Diarra, Issa 1074, 744 Dorkenoo, Ameyo 112, 114, 115, 329, Ebel, Gregory 416, 1094 Ersanli, Dilaver 628 Diarra, Souleymane 481 821, 1134 Eberhard, Mark L. 466 Esaki, David 69 Diassiti, Angelina 985 Dorn, Patricia 21 Echeverry, Diego F. 532, 533, 886 Escalante, Ananias A. 2, 3 Diawara, Aissatou 464 Dorsey, Grant 1066, 366, 537, 663, Ecker, Andrea 520 Espérance, Ouedraogo 572, 899, 903, Diaz, Annette 1096 895 Edelman, Robert 897 915, 929 Díaz, Francisco 432, 794 Dotson, Ellen 419, 756 Eder, Susanne 1126 Espino, Ana M. 272, 385 Díaz, Fredi A. 778 Dougan, Gordon 467 Edillo, Frances E. 803 Espinosa, Benjamin J. 942 Diaz, Gustavo 886 Doumbia, Mory 1039, 845 Edith, Bougouma 572, 899, 915, 929 Espinoza, Benjamin 651 Díaz-López, Manuel 463 Doumbia, Mama N. 62 Edmond, Karen M. 735 Espinoza, Eddy 130 Dicko, Alassane 1075, 1137, 541, 552, Doumbia, Saibou 845, 1039 Edoh, Dominic 277 Espinoza, Jose R. 702 565, 856 Doumbia, Seydou 481, 598, 845, 1039 Edstein, Michael D. 152 Espitia, Claudia M. 661 Dicko, Idrissa 252 Doumbia, Salif S. 1083, 113, 332 Edwards, Nick 1077 Essbauer, Sandra 728 Dicko, Mohamed 856 Doumbo, Ogobara 149, 172, 27, 208, Egbuji, Anthony 287 Esteban, Margarita T. 14 Dickson, Anne M. 493 541, 552, 566, 744, 856, 1007, 1042, Egner, Lisa 1010 Etang, Josiane 575 Dickson, Laura 230, 544, 928 1074, 1075, 1107, 1137 Egyir, Beverly 539, 914 Eugene, Ruberanziza 609, 705 Dida, Gabriel 51, 246 Doumbo, Safi atou 1007 Eichinger, Daniel 469 Evans, Carlton A. 260, 261, 264, 605, Dieppa, Migda 777 Doumtabe, Didier 1007 Eigege, Abel 105, 116, 444, 448, 453, 734, 736 Diez, Mirta 38 Douoguih, Macaya 224 640 Evans, Christopher C. 822 Diggs, Carter 743, 1074, 1078 Dow, Geoffrey S. 298, 873, 883 Eisele, Thomas 238, 601, 866 Evans, Darin 444, 453, 640 Dijbo, Aichatou 1052 Dozie, Ikechukwu N. S. 197 Eisen, Lars 596, 9 Evans, Jennifer 211 DiMiceli, Lauren 621 Drahota, Jan 46 Eisen, Rebecca J. 9 Ewer, Katie 1077 Dimon, Michelle 892 Drake, Lisa L. 239 Eisenberg, Joseph N. 656 Eyamba, Albert 1023 Dimopoulos, George 240, 792 Drakeley, Chris 1030, 680, 898 Eisenger, Stehen W. 859 Eyase, Fredrick 885 Ding, Charles 829 Drexler, Anna 956 Ejigiri, Ijeoma 1151 Eyul, Patrick 305 Dinis Ferreira, Isabel 335 Drobeniuc, Jan 650 Ekala, Marie Thérèse 335 Diouf, Ababacar 1039, 1067, 1075, Druilhe, Pierre 1076, 205, 560 Ekland, Eric 522 F 845 Dubey, J. P. 692 Eksi, Saliha 316 Direny, Abdel N. 708 Dubischar-Kastner, Katrin L. 1126 Eksteen, Francois J. 738 Faaruia, Marc 1019 Dirks, Kathryn 414 Dubois, Marie-Claude 1032 El Alkamy, S. 712 Fabiszewski, Anna M. 1063 Dissanayake, Senarath 58 Duffy, Michael F. 910 El Sahli, Hanaa 1067 Fabre, Valeria 379 Dissous, Colette 283 Duffy, Patrick E. 1040, 136 El Sayed, Nasr 712 Fader, Joseph E. 587 Dittmer, Dirk P. 31, 783 Duffy, Tomas 38 El-Mohamady, Hanan 649 Faghiri, Zahra 1132 Diuk-Wasser, Maria A. 389, 591 Duggal, Priya 716 El-Sayed, Badria B. 175 Fahey, Paul 1076 Dixit, Rajnikant 595 Duh, Darja 286 El-Zaki, Salah Eldin 175 Fair, Joseph 727 Dixon, Phil 1014 Dumas, Rafaele 394 Elder, John 352, 798 Fairhurst, Rick M. 303, 344, 481, Djalle, Djibrine 860 Dumas, Rafaela 437 Eldridge, Bruce F. 980 845, 1039 Djegbe, Innocent 574 Dumler, J. Stephen 682, 869 Elizondo, Douglas 423 Fairlie, David 158 Djibo, Ali 325 Dumonteil, Eric 21, 50 Elliott, Suzanne 1076 Faiz, A. 830 Djibou, Ali 1052 Duncan, Elizabeth H. 935, 936, 937 Elliott, Salenna R. 910 Faiz, M.A. 135 Djimde, Abdoulaye 27, 149, 172, 208, Duncan, Robert 491 Ellis, Alicia 425 Falade, Adegoke G. 851 1042 Dunford, James C. 578 Ellis, Bill 833, 833 Falade, Catherine O. 501, 850 Djogbénou, Luc S. 1090 Dunk, Duane D. 1064 Ellis, Ruth D. 1075, 1137, 541, 552, Falade, Mofolusho 173, 521 Djuardi, Yenny 709 Dunkley, Sophie 222, 546, 678 565 Famenini, Shannon 1116 Djumaeva, N.E. 405 Dunlap, Brett 761 Elswaifi , Shaadi F. 400, 619, 622, 696 Fandeur, Thierry 2, 335, 891 Dlugosz, Lisa 1037 Dunn, John R. 417, 761 Elwood, Daniel 396, 397 Fang, Li-Qun 731 Dobano, Carlota 160, 1070 Dunning-Hotopp, Julie C. 674 Elyazar, Iqbal 185 Fantu, Ribka 1062 Dobler, Gerhard 728 Dunstan, S.J. 1109 Emch, Michael 1026 Farag, Tamar 85 Dodean, Rosie 295 Duong, Kathy 100 Emil Habashy, Engy 270 Farag, Tamer H. 1141 Dodoo, Daniel 914 Duparc, Stephan 300, 517 Emmanuel, Ezekiel 1137 Farah, Idle O. 279 Dogbe, Komi 1134 Duque, Victoria 206 Emukah, Emmanuel 1021 Farajollahi, Ary 1093 Dogcio, Diane 826 Duraisingh, Manoj T. 878 Endy, Timothy P. 32, 355, 438 Farfan-Ale, Jose Arturo 596, 644, Dogonyaro, Priscillia 448 Durand, Fiona 847 Engelson, Erin J. 489 1122, Doka, Najah I. 471 Durand, Salomon 23, 529, 925 Engoru, Charles 863 Farias, Kleber 93, 291 Dokomajilar, Chris 377 Durbin, Anna P. 396, 397, 1137 Enk, Martin J. 276 Farid, Hoda A. 670 Dolo, Amagana 1074 Durvasula, Ravi 762, 763 Ennis, Francis A. 1099, 355 Farnon, Eileen C. 726 Dolo, Housseini 1081, 1083, 1084, Dutra, Walderez O. 37 Enwere, Okezie O. 501 Farooq, Fouzia 570, 743 113, 332 Dutta, Sheetij 1037, 919, 940 Enyaru, J. C. K 487 Farooq, Muhammad 578 Dominguez Vazquez, Alfredo 1024 Duval, David 280 Enyong, Peter A. 328, 1023 Farrance, Christine E. 1038 Don, Robert 132, 748, 751, 829 Dvorin, Jeffrey D. 878 Epperson, Diane 714 Farrar, J.J. 1109 Donaldson, Eric 779, 790 Dwyer, Dennis M. 499 Epstein, Judith 941, 1078 Faruque, A.G. 323, 715 Dondorp, Arjen M. 135, 523 Dyer, John 68 Erb, Steven M. 785 Faruque, Labib I. 725 Donduashvili, Marina 754 Dzimianski, Michael T. 822 Erdem, Guliz 69 Farzeli, Arik 420 Donelson, John E. 1071 Eremeeva, Marina E. 414, 616 Fasina, Abiola 547 Dong, Carolyn 878 E Erhart, Annette 558 Fasina, Folorusho D. 287 Donnelly, Christl 898 Eric, Prieur 560 Faulde, Michael 728 Donner, Marie-Noelle 1032 Eapen, Alex 171 Erickson, Jennifer S. 233 Favaloro, Liliana 38 Donofrio, Gina C. 33 Earhart, Kenneth 649 Erickson, Sara 123 Favaloro, Roberto 38 Doolan, Denise L. 743, 1007, 1078 Eastep, Nicole E. 577 Ermler, Megan 290, 293 Fawole, Adefolarin A. 226 Dorabawila, Nelum 636 Eastman, Richard T. 5 Fay, Michael P. 1137, 541, 552

236 Author Index The number(s) following author name refers to abstract number.

Faye, Ousmane 481 Fonseca, Dina 1093 Gantt, Soren 149 Gilman, Robert H. 59, 260, 261, Featherstone, David 443 Fontenille, Didier 362, 720 Gao, Qian 262 310, 484, 605, 658, 734, 736 Feby Cahya, Florence 333 Fontes, Cor Jesus F. 200 Gao, Qi 372, 867 Gilman, Robert H. on behalf of TB Fedders, C. 1078 Foppa, Ivo M. 1097, 977 Gao, Xiugong 297 Collaborative Group, 264 Fedorova, Natalia 9 Ford, Byron 741 Gara, Samuel N. 304 Gilson, Paul R. 318 Feikin, Daniel 1141, 294, 73 Ford, Carolyn M. 605 Garba, Amadou 1052 Gimnig, John 1027 Feitosa, Taysa M. 39 Ford, Louise 817 Garboczi, David N. 344 Giordani, Bruno 345 Feleke, Beniam 1062 Formenty, Pierre 652 Garcia, Andy 425 Giraldo, Ana C. G. 180 Felgner, Philip L. 1007 Fornadel, Christen M. 18, 19, 971 Garcia, Enid 440 Giraldo-Calderon, Gloria I. 959 Felices, Vidal 996 Forquer, Isaac 295 Garcia, Hector H. 310, 311, 59 Girard, Yvette A. 9 Felzemburgh, Ridalva D. M. 1136 Forshey, Brett M. 352, 653, 654, Garcia, Josefi na 267, 268, 987 Giraudoux, Patrick 55 Feng, Lisa 816 995 Garcia, Márcio H. O. 308 Gire, Stephen K. 289 Feng, Shuang 813 Forsyth, Simon 1046 Garcia Fernandez, Maria A. 469 Girerd, Yves 394 Feng, Zheng 1046 Fortin, Anny 877, 988 Garcia-Bustos, Jose 520, 878 Githeko, Andrew 249, 258, 679 Fenwick, Alan 609, 705, 823, 1052, Foster, Jeremy 674, 1112 García-Rejón, Julián 596, 644, 1122 Gitti, Rossitza K. 344 106, 704 Foster, Jerome 689 Garcia-Rosa, Miryam I. 166 Gittis, Apostolos G. 344 Ferdig, Michael T. 341, 7 Fowble, Joseph W. 857 Garcia-Sastre, Adolfo 788 Gizatulina, N R. 403 Ferguson, Neil 898 Fowkes, Freya J. I. 542, 910 Gardiner, Donald L. 299, 527 Glenn, Gregory M. 714 Fernandes Silva-do-Nascimento, Fox, LeAnne 1020 Gardner, Malcolm 373, 857, 1008 Glenn, Justin D. 1013 Teresa 722 Fracisco, Susan 298, 512, 550 Gardner, Sean R. 873 Glennon, Erin G. 14 Fernandez, Connie 446 Francek, Carolyn 170, 507 Garner, Paul 633 Glesby, Marshall J. 831 Fernandez-Salas, Ildefonso 644 Francis, F. 548 Garonga, Tino 1131 Glover, Simon J. 1041, 327 Fernandez-Sesma, Ana 788 Francischetti, Ivo M. B. 945 Garrido Gonzales, Rommel 942 Glynne, Richard J. 170, 507 Ferragine, Christine E. 638 Francisco, Javier 878 Garry, Robert F. 1065, 727 Goba, Augustine 727 Ferraro, Aimee 401, 406 Franco, Jessica 260 Garze, Virginie 1032 Godeaux, Olivier 1074 Ferreira, Anielly A. 251 Frandah, Wesam M. 408, 410 Gasasira, Anne F. 366 Goethert, Heidi K. 12 Ferreira, António E. N.. 490 Franetich, Jean-Francois 1036 Gaspard, Amanda N. 310 Goez Rivillas, Yenny 794, 797, 801 Ferreira, Cynthia 335 Frangos, John 843 Gaspard, Kabanda 609 Goff, Jay 289 Ferrell, Robert E. 140, 142, 555, 556 Frédéric, Simard 719 Gatti, Clemence 1019 Goggins, James A. 54 Ferro, Cristina 253 Freilij, Hector 834 Gatton, Michelle 6, 28, 534, 860 Gohara, Beth 125 Fidock, David 5, 520, 522, 888, Freitas, Rafael M. 1015 Gaudier, Jose F. 385 Goldberg, Tony 599 890, 891 Frempong, Kwadwo K. 277 Gaugler, Randy 1093 Goldsmith, Rachel B. 129 Fieck, Annabeth 762, 763 Freund, Yvonne 132, 748, 816, 829 Gaukel, Eric 748 Gollob, Kenneth J. 37 Filice, Carlo 1101 Frevert, Ute 1035 Gaur, Upasna 39, 660 Gomes, Melba 505 Fillinger, Ulrike 249 Freye, James 761 Gavrilova, Olga N. 809 Gómez, Giovan F. 958 Fimmers, Rolf 1102 Fried, Michal 1040, 136 Gayo, Valeria 702 Gomez, Jorge 267, 268 Fink, Doran L. 671 Friedland, Gerald 738 Gazzinelli, Andrea 1051, 382 Gomez, Regis 481 Fink, Valeria 312 Friedman, Jennifer F. 379, 462, 99 Gbadeyanka, Confort 259 Gomez, Tangni 351 Finney, Constance 367, 502, 848, Fritz, Gary N. 722 Gbotosho, Grace 154, 855, 868 Gomez-de-las-Heras, Frederico M. 985 Fruth, A. 72 Gbotosho, Olusola G. 521, 531 878 Fischer, Marc 443, 804 Fryauff, David J. 225, 549, 669, Geary, Timothy 120, 331 Goncalves, Loredana 498 Fischer, Peter U. 119, 674, 709, 814, 942, 1079 Gebre, Teshome 538 Gonçalves, Jailey M. 1015 1112 Fu, Guoliang 580 Gebregeorgis, Elizabeth 561 Gong, Hong-Fei 358 Fish, Durland 10 Fuchs, Edward 859 Gego, Audrey 1036 Gonzaga, Victor 1138, 657, 446 Fisher, Laurel 504 Fuchs, Jeremy 123, 235 Gelb, Michael H. 170 Gonzalez, Anajulia 827 Fitzgerald, Margaret 667 Fujiwara, Ricardo T. 200, 382 Georghiou, Sophia 468 Gonzalez, Armando 59, 310 Fitzpatrick, Meagan C. 447 Fukuda, Mark 22, 179, 858, 894, Gepi-Attee, R 84 Gonzalez, Carolina 702 Fleckenstein, Lawrence 224, 300, 896, 907, 1079, Gerena, Lucia 873, 874, 883, 892 Gonzalez, Isidro 311 517 Fuller, Douglas O. 433 Gerhardt, Reid R. 592 González, John J. 958 Flessner, Christa 211 Furuya, Tetsuya 316, 838 Gershman, Mark 401, 406 González-Zeno, Gladys 354 Fligner, Corinne L. 136 Futabi, Godfred 277 Gerstl, Sibylle 222, 546, 678 Goodenough, Christopher 875 Flores, Diana 422 Futami, Kyoko 51 Getachew, Asefaw 538 Goodman, Anna L. 1077 Flores, Rosemary 41 Gething, Peter W. 184, 185, 192, Goodman, Catherine 1053, 1054 Flores-Suarez, Adriana 1091 G 458, 1028 Gopi, P.G. 1085 Florey, Lia S. 1047 Gettayacamin, Montip 298, 873 Gopinath, Vadiraj 166 Florez, Lina 228 Gadalla, Amal 175 Ghanchi, Najia 176, 177, 183 Gordon, Aubree 285, 351, 94 Flyer, David 714 Gadalla, Nahla B. H. 175 Ghani, Azra C. 545, 898, 1030 Gordon, Megumi 1053 Fobi, Grace N. 328 Gagaring, Kerstin 507 Ghedin, Elodie 673, 675 Gordon, Scott 733 Focks, Dana 425 Galagan, James 378 Ghersi, Bruno 292 Goronga, Tinopiwa 320 Fofana, Bakary 172 Gallegos, Angela C. 977 Gibbons, Robert V. 32, 786, 796, Goshu, Samrawit 879 Fogg, Carole 26 Galvani, Alison 10, 447 994 Gottstein, Bruno 1101 Foggie, Tarra 600 Galves Montoya, Mariella 23, 529 Gibbons, Tom 733 Gotuzzo, Eduardo 271, 647, 768 Folarin, Onikepe A. 531, 855, 868 Gamboa, Dionicia 376, 558, 860, Gibson-Corley, Katherine 483 Goudsmit, Jaap 1033, 569 Foley, Desmond H. 968 922, 923 Gicheru, Michael 279 Gourbal, Benjamin 280 Foley, Michael 1037, 847, 919 Gamero, Maria E. 987, 990 Gichuki, Charity W. 140 Gowda, D. Channe 344, 344 Folsom, Corrine M. 389, 591 Gampietro, Corradin 915 Gil, José Pedro 178, 886 Gowda, Kalpana 568 Fongoro, Sahare 772 Gandhi, Neel R. 738 Gilbert, Alexa 782 Gracia, Gabriel 429 Fonnie, Richard 1065, 727 Ganeshan, Harini 571, 743 Gilbert, Sarah C. 1077 Graczyk, Thaddeus 691 Fonseca, Benedito A. L. 93, 291, Ganley-Leal, Lisa 346, 348 Gilligan, James H. 170 Graf, Paul C. F. 23, 446, 529, 554, 434, 781 Gansane, Adama 932, 934 Gillissen, Gert 1033, 569 657, 902, 942

237 Author Index The number(s) following author name refers to abstract number.

Graff, Joel W. 493 Gurley, Emily S. 64, 288, 324, 687, Harris, Jason B. 323, 610, 715, 716, Hinkle, Mary K. 612, 613 Graham, James E. 1145 725, 1000, 1106 1144, 1145 Hinnebusch, B.J. 418 Grais, Rebecca 325 Gürtler, Ricardo E. 756 Harris, Karen 919 Hinrichs, Dave 295 Grant, Rebecca J. 811 Gurumurthy, Srividya 491 Harris, Steven 107 Hira, Parsotam R. 60 Graves, Patricia 116, 538, 1021, Gutierrez, Gamaliel 423 Harrison, Bruce A. 52 Hirayama, Kenji 126, 837 Gray, Darren J. 1046 Gutierrez, Lina 718, 722, 958, 965 Harrison, Lisa 314 Hise, Amy G. 45, 290, 293 Gray, Kimberly K. 999 Gutman, Julie R. 4 Hart, Julie 68 Hittner, James B. 553, 555, 557, 742 Gray, Laurie 45, 255 Gutteridge, Clare E. 874 Harter, Lynn M. 457 Ho, Benjamin 1066 Gray, Michael R. 269 Guy, Bruno 437 Hartl, Daniel 378 Ho, May 334 Green, Michael D. 529 Gyan, Ben 913, 914 Hasan, Mahtab U. 135 Ho, Mei-Fong 860 Green, Sharone 1099, 355 Gyorkos, Theresa W. 187, 460, 461 Hassan, Che Abdullah 695 Hocart, Simon J. 889 Greenberg, Lior 336 Hassan, Hassan K. 969 Hochberg, Natasha S. 99 Greenberg, Robert M. 1131, 383 H Hassan, Khaled 712 Hodges, James A. 1025 Greenhouse, Bryan 1066, 895, 377 Hassan, Yasser A. M. 1105 Hodgson, Abraham 225, 549, 669 Greenwood, Brian 509 Haagsma, Karl 652 Hattasingh, Weerawan 61, 89 Hoerauf, Achim 1102, 824 Gregory, Michael 455 Haas, Helmut 346, 348 Havlir, Diane 366, 537 Hoffman, Paul S. 630 Gregory, Michael J. 768, 78, 79 Habbanti, Shadreck 18, 19 Havt, Alexandre 75, 80, 81, 83 Hoffman, Stephen L. 206, 897, 941 Gregory, Teresa 419 Habbema, Dik J. 328 Hawel, Leo 661 Hoffmann, Juliano L. 321 Grenfell, Bryan 325 Habomugisha, Peace 818 Hawkes, Michael 1118, 985 Holbrook, Michael R. 1123, 808, 999 Grevelding, Christoph 283 Hacker, Kari 790 Hay, John 809 Hollingdale, Michael 743 Grewal, Paul 936 Haddad, João Paulo A. 382 Hay, Simon I. 184, 185 Hollingsworth, Deirdre 898 Gribaldo, Simonetta 335 Haddow, Andrew D. 592 Hayton, Karen 888 Hollingsworth, Jessica 18 Grieco, John 17, 242, 600, 759, 967, Hadi, M. A. 875 Healy, Sean 1093 Hollingsworth, Robert 313 973, 975 Hafez, A. 712 Heilek, Gabrielle 35 Hollm-Delgado, Maria-Graciela 264 Griffi n, Jamie 545, 898 Hahn, Sigrid 547, 870 Heinz, Michael 118 Holmes, Edward C. 94 Griffi n, Jennifer B. 681 Hahn, William 107, 438 Helegbe, Gideon K. 837 Holt, Deborah 8 Griffi ng, Sean 3 Haider, Mohammad S. 1106 Helinski, Michelle E. 1017, 1018 Holtzman, Douglas A. 41, 1038 Griffi th, Matthew E. 612, 613 Haile, Yoseph 316 Helmy, Hanan H. 670 Homaira, Nusrat 1106, 64 Griffi th, Qyana 346, 348 Hailemariam, Tiruneh 122, 673 Hemingway, Janet 597, 1091 Hombach, Joachim 399 Griffi ths, Kathryn 123 Hajiyev, Huseyn 1001, 451 Hemingway-Foday, Jennifer 224 Hommel, Mirja 910 Griffi ths, Ulla K. 735 Hajiyeva, Ayten 1001 Hendriks, Jenny 1033 Homsy, Jaco 663 Grigg, Michael 690 Hajjeh, Rana 735 Hendrix, Craig W. 859 Hong, Liu 806 Grijalva, Mario 718 Halasa, Yara A. 1093, 776, 777 Heng, Suvimon 326 Hong, Sung-Jong 273 Grimberg, Brian 336 Halder, Amal K. 1000, 1061 Henn, Matthew R. 351, 94, 96 Hope, Andrew G. 686 Grobbel, Mirjam 72 Hall, Eric R. 713, 768, 78, 79 Henry, Noëlie G. 932 Hopkins, Donald 1023, 818 Grogl, Max 297, 750, 833 Hall, James E. 752 Henry-Halldin, Cara N. 255 Hoque, M.G. 135 Gros, Philippe 877 Halsey, Eric S. 1138, 445, 446 Hensley, Lisa 289 Hora, Richardo 111 Gross, Isaac 1053 Hamainza, Busiku 732 Hepburn, Matthew J. 1001, 451, 773 Hora, Ricardo A. 1139 Grunau, Christoph 280 Hamel, Mary J. 1027 Heppner, Donald G. 1010, 1074 Horby, Peter 98 Gu, Charles 164 Hamer, Davidson H. 650, 666, 732, Herbein, Joel 766 Horio, H. 246 Gubler, Duane J. 424, 88, 91 900, 997 Herman, Joanna S. 1050 Horne, Peter 435 Guclu Kilbas, Zeynep 53, 628 Hamer, Gabriel 599 Hernandez, Jean 904 Hoshuyama, Tsutomu 409 Guerenstein, Pablo G. 419 Hammer, Jeffrey S. 1058 Hernandez, Salvador 408, 410 Hospenthal, Duane R. 269, 611, 612, Guerin, Philippe J. 26 Hammerich, Asmus 709 Hernandez, Vincent 816 613 Guerra, Carlos A. 184, 185 Hampson, Katie 447 Hernandez, Yunuen 499 Hossain, Amir 135 Guerrant, Richard L. 84, 75, 80, 81, Han, Eun-Taek 867 Herrera, Beatriz 734 Hossain, M. Jahangir 288, 324, 687, 82, 83, 630, 1140 Han, Ik-Hwan 625 Herrera, Socrates 563 725, 1000, 1097, Guevara, Carolina 995, 998 Han, Pauline 401, 406 Herrera-Aguilar, Melba 21, 50 Hostomska, Jitka 47 Gueye, Serigne M. 330 Handali, Sukwan 310, 59 Herrin, Bradley R. 369 Hotez, Peter J. 469 Guiguemde, Robert T. 252 Hanelt, Ben 1049 Herve, Jean Pierre 957 Hotor, Vida E. 819 Guillaneux, Stephanie 219 Hanington, Patrick C. 699 Herwaldt, Barbara L. 134 Hotsmann, Rolf 211 Guimaraes, Ana 817 Hanna, Jeffrey 435 Hewson, Roger 809 Hougard, Jean-Marc 1090, 223 Guimarães, Luiz H. 37, 831, 832 Hansen, Immo A. 239 Hexom, Braden 870 Houpt, Eric R. 629, 631, 694 Guindo, Ando 1074 Happi, Christian 154, 521, 531, 855, Heysell, Scott K. 738 House, Brent 1032 Guindo, Aldiouma 541 868 Hickey, Patrick 306 Howell, Katherine 1069 Guindo, Amadou 961 Haque, Rashidul 315, 631, 766, 835 Hickingbottom, Barbara 104 Howes, Rosalind E. 184 Guindo, Merepin A. 541, 552, 1083 Harding, Simon P. 1041 Hien, T.T. 1109 Hoy, Ronald R. 590 Guindo, Ousmane 1137, 541, 552 Hardy, Victoria 600 Higgins, Sarah J. 1044 Hoyos, Oladier 432 Guirakhoo, Farshad 1099 Hare, Lisa 1055, 156, 219 Higginson, Amanda 306 Hsiao, Hui Mien 90, 441 Gulia, Sandrine 394 Harhay, Michael O. 747 Higgs, Stephen 646, 684, 976 Hsieh, Szu-Chia 29 Gunasena, Sunethra 780 Harlow, Wesley 722 Hightower, Allen 85, 294, 652 Hsu, Fong-Fu 125 Gunsaru, Bornface 876 Harmen, Sonia P. 108 Hii, Jeffery 860 Hsu, Kan-Lin 411 Guo, Jiagang 1046 Harrington, Laura C. 1017, 1018, 590 Hildebrand, John G. 419 Hu, Dale 645 Guo, Qin 1034 Harrington, Whitney E. 1040 Hildebrandt, Jessica 722 Hu, Ruixin 473 Guo, Xiang 364 Harris, Brande M. 612 Hill, Adrian V. S. 1077 Hu, X. 902 Gupta, Megha 1011 Harris, Caroline A. 362 Hill, Catherine A. 49, 959, 1014 Hu, Yanhui 1144 Gupta, Vinay 895 Harris, Erin 295 Hill, Kevin J. 969 Hu, Yan 468 Gurarie, David 186, 639 Harris, Eva 285, 351, 356, 422, 423, Hillesland, Heidi 762, 763 Huaman, Alfredo 653 Gurjav, Ulziijargal 1098 428, 431, 94, 96 Hillyer, Julián F. 955, 1013 Huaman, Jose L. 987, 990 Hilton, Isaac B. 783 Huaman, Maria Cecilia 1039, 845

238 Author Index The number(s) following author name refers to abstract number.

Huang, Claire Y. H. 393, 785, 787, Iwanaga, Shiroh 215 John-Stewart, Grace 369, 371 Kakembo, A. 487 791, 795 Iyer, Lakshmi R. 618 JohnBull, Eric A. 630 Kaku, Koki 551 Huang, Fusheng 218 Izumiyama, Shinji 144, 182 Johnson, Allison J. 91 Kakuru, Abel 663 Huang, Junjun 417, 761 Johnson, Barbara W. 443, 804 Kalamya, Julius 663 Huang, Ruiling 888 J Johnson, Charles 378 Kalavska, Andrea 476 Huang, Scott Yan-Jang 802 Johnson, Kiersten B. 908 Kalayanarooj, Siripen 355, 796 Huang, Yuefang 118 Jackson, Sebeza 705 Johnson, Louise 104 Kalesha, Penelope 732 Huber, Erin 14, 608 Jacob, Shevin T. 322, 471 Johnson, Ronald 888 Kalilani, Linda 303 Hübner, Marc P. 1080, 1082, 1086 Jacobs, Robert 132, 748, 829 Johnson, Wesley O. 980 Kalsy, Anuj 1144, 1145 Huda, M. Tarique 1000, 1061 Jafari, Hamid S. 804 Johnston, Kelly L. 333 Kaltenboeck, Astrid 1126 Hugard, Jean M. 1088 Jafri, Sana 177, 183 Johnston, Richard B. 1061 Kalua, Khumbo 609 Huggins, John 289 Jago, Jeffrey D. 508 Johnston, Stephanie P. 466, 56, 627 Kamarudin, Adeeba 477 Hui, George 1068 Jahan, Yasmin 725 Joice, Regina C. 143 Kamate, Beh 1137, 541, 552 Huijben, Silvie 893 Jambou, Ronan 335, 7 Jolly, Anna K. 634, 1020 Kamchonwongpaisan, Sumalee 173, Humphries, Debbie 314 Jamerson, Melissa 622 Jolly, Pauline 916 209, 521 Hunsperger, Elizabeth 1096, 354, James, Anthony A. 1115, 204, 361, Jones, Carl J. 592 Kamgang, Basile 957 440 962 Jones, David S. 939 Kamgno, Joseph 120 Hunt, Philip 853, 854 James, Mark 238, 601 Jones, Jeremy C. 992 Kamhawi, Shaden 481 Huq, Sayeeda 1103 Jamet, Helen V. Pates. 582 Jones, Jeffrey L. 466, 627 Kamholz, Karen 732 Hurwitz, Ivy 762, 763 Jamil, Kazi M. 835 Jones, Matthew J. 1100 Kamili, Saleem 650 Husain, Mushtuq 324 Janse, Chris J. 215, 927, 1036 Jones, Malcolm K. 1133 Kamya, Moses 366, 537, 663, 1066 Husain, M. M. 725 Jansen, Frans Herwig 988 Jones, Timothy F. 417, 761 Kanayama, Atsuhiro 551 Husain, Tupur 570 Jansen, Herwig 513, 851 Jones-Sanpei, Hinckley 314 Kandeel, A. 712 Hussain, Mobassir 666, 900 Jany, William 581 Jongkaewwattana, Chulanee 261 Kaneko, Akira 1114 Hussem, Kittinun 994 Jaramillo, Berta N. 794 Jonsson, Colleen B. 610, 813 Kaneko, Izumi 215 Hutubessy, Raymond 399 Jarilla, Blanca 379 Jorakate, Possawat 615, 993 Kaneko, Osamu 126, 372 Huy, Nguyen T. 837 Jarillo-Luna, Adriana 620 Jordan, Stephen J. 559, 943 Kaneko, S. 246 Hwant, Jeeseong 840 Jarman, Richard G. 786, 994 Jorge, Daniel M. M. 434 Kaneko, Takamasa 944 Hwang, Jimee 538 Jarnagin, Kurt 132, 748, 829 Joseph, Hayley M. 814 Kang, Gagandeep 459 Jaron, Peter 1141 Josephine, Obiezu 1021 Kang, Hye Lim 273 I Jarrett, Clayton O. 418 Josh, Ruxin 609, 705 Kang, Hae Ji 686 Jasinskas, Algis 1007 Joshi, Hema 171 Kanneh, Lansana D. 1065 Ibadov, Ravshan A. 403, 404 Jasinskiene, Nijole 1115 Joshi, Manju B. 499 Kano, Shigeyuki 212, 924 Ibadova, Gulnara A. 74, 403, 405 Javanbakht, Hassan 35 Joyce, Jonathan D. 257 Kansiime, Edgar 726 Ibarra-Juarez, Luis 644 Javed, Anam 231 Juarez, Marisa 312 Kante, Ousmane 552 Ibrahim, Ima N. 420 Jaya, Ungke A. 420 Juliano, Jonathan 1026, 681, 852, Kao, Cheng-Yuan 468 Ibrahim, Marwa 58 Jean Baptiste, YARO B. 921 Kao, Chuan-Liang 802, 92 Idachaba, Stella 287 Jean Baptist, Yaro 572, 899, Juliano, Steven A. 587 Kapito-Tembo, Atupele P. 667 Ige, Olusoji M. 259 903¸915, 929 Jullien, Vincent 301 Kaplan, Ray 464, 822 Igu, Jennifer 307 Jean Pierre, Hervé 719 Juma, Elizabeth 192, 301 Kapoor, Anil 986 Ilett, Kenneth F. 508, 510 Jean-Louis, Pérignon 560 Jun, Gyo 181 Kappe, Stefan H. 1011 Im, Su-Jeong 625 Jedlicka, Anne E. 117 Jung, Bong-Kwang 623, 626, 632 Karanja, Diana M. S. 381, 634 Imerbsin, Rawiwan 512 Jekle, Andreas 35 Jung, Ji Sung 273 Karasuyama, Hajime 380 Imeru, Alemush 541, 552 Jenison, Rob 583 Junushov, Asankadyr T. 809 Karchmer, Adolf W. 650, 997 Imnadze, Paata 773 Jenkins, Tanya 880, 881 Jusot, Viviane 354 Kargbo, Kandeh 1065 Imran, Labib 1106 Jenks, Matthew 132, 748, 829 Jusuf, Hadi 1104 Kariuki, Michael 213 Imrie, Allison 30, 91 Jeronimo, Selma M. B. 39 Jwan, Shu-Fan 92 Kariuki, Njenga 73 Inglese, James 888 Jessup, Christine 717 Kariuki, Simon 1027 Ipuge, Yahya 1053 Jia, Fuli 813 K Kariuki, Thomas 279, 933 Iqbal, Asma 477 Jiang, Dao Jun 119, 124, 1112, Karki, Prahlad 57 Iqbal, Jamshaid 60 Jiang, Hongying 316, 888 Kaba, Stephen A. 1034 Karl, Stephan 186, 862 Iqbal, Shehzad 1044 Jiang, Ju 412 Kabanda, Alice 730 Karunajeewa, Harin A. 510 Ireland, Kathleen 849 Jiang, Rays H. Y. 339 Kabanywanyi, Abdunoor M. 668 Kasinathan, Ravi S. 1131, 383 Iriko, Hideyuki 562 Jiang, Suping 750 Kabatereine, Narcis B. 458 Kasper, Matthew R. 76 Irizarry-Pérez, E. Brian 354 Jima, Daddi 538 Kabir, Mamun 766 Kassogue, Yaya 588 Isaac Traore, Zoumana 149 Jimenez, Alfons 1070 Kabore, Martin 704 Kastens, Will 1022 Isaacs, Alison 1115 Jimenez, Mirna 267, 268 Kabyemela, Edward 1040 Katabarwa, Moses N. 818, 1023 Isfandari, Siti 737 Jimenez Campos, Lourdes 942 Kachur, S. Patrick 4, 538, 664, 676, Katera, Fredrick 366 Ishengoma, D. 548 Jimenez-Diza, Maria Belen 160 864, 1054 Kathcart, April 1079 Ishida, Hiroshi 297 Jin, Xiannu 880, 881, 883 Kaewpan, Anek 615, 993 Kato, Cecilia 414 Ishino, Tomoko 927 Jip, Nimzing 116 Kaggwa, Dan S. 305 Kattula, Deepthi 459 Islam, M. Saiful 64, 324, 725 Jiram, Adela I. 1113 Kagirita, Atek 1142, 1143, 726 Kaufusi, Pakieli 86 Ismayilov, Afrail 1001, 451 Jitpimolmard, Suthipun 409 Kagucia, Wangeci 397 Kaul, Rupert 367 Isoe, Jun 947, 948 Jiya, Jonathan 116, 640 Kahigwa, Elizeus 1054, 664, 676, Kaur, Jaspreet 133 Issa, Nébié 572, 899, 915, 929 Jiz, Mario A. 99, 379, 462 864 Kawazu, Shin-ichiro 212, 924 Issiaka, Soulama 572, 899, 915, 929 Jobe, Ousman 740 Kahirita, Samuel 726 Kayala, Matthew A. 1007 Ito, Akira 55 Johari, S. 548 Kahn, Geoffrey 658 Kayatani, Alexander K. K. 563 Itoh, Makoto 1019, 835 John, Chandy C. 906, 199, 203, 204, Kain, Kevin C. 139, 343, 367, 502, Kayentao, Kassoum 1007 Ittiprasert, Wannaporn 1111, 700, 345, 849, 863, 1025, 1031, 1066 848, 877, 985, 1044, 1045, 1118 Kazakov, Jordan 986, 991 701 John, Vulule M. 204 Kaitaba, Oscar 450 Kazumba, Mbiyangandu L. 485

239 Author Index The number(s) following author name refers to abstract number.

Kazura, James W. 199, 290, 1022 King, Jonathan D. 116 Kopaczewski, Jessica 816 Kweyamba, Vianney 1142 Keating, Joseph 238, 601, 866 King, Jonas G. 1013, 955 Koram, Kwadwo A. 225, 270, 539, Kwok, Kin On 282 Keenan, Martine 751 Kinkade, Carl 294 549, 669, 767, 914, 1119, Kyebambe, Peterson S. 370 Keesen, Tatjana S. L. 37 Kinney, Richard M. 393, 785, 787, Koros, Joseph 544 Kyle, Dennis E. 42, 515, 534, 6, 836, Kehinde, Aderemi O. 259 791, 795 Korten, Simone 824 892, 931 Keita, Adama D. 62, 63, 332 Kinuthia, Joseph M. 1049 Koru, Ozgur 134, 53, 628, 812 Kyoko, F. 246 Keita, Moussa 598 Kiphart, Courtney 499 Korva, Miša 286 Keita, Mamadou M. 62 Kirk, Kiaran 890 Kosasih, Herman 1104 L Keita, Mahamadou M. 63 Kirsch, Philipp 973 Kostense, Stefan 1033 Keita, Nadouma 856 Kirumbi, Edward 450 Kotloff, Karen 1141, 62, 63, 85 LaBaer, Joshua 1144 Keita, Somita 481 Kisoka, William 823 Koudou, Guibehi B. 597 Labbé, Geneviève 580 Keitel, Wendy 1067 Kitamura, Kei 182 Koukounari, Artemis 704 LaBeaud, A. Desiree 45, 290, 293 Kelleher, Alan 468 Kitron, Uriel 254, 352, 435, 589, 593, Kouriba, Bourema 1074 Lachica, Ruben 422, 428 Kelley, James F. 86 599, 756, 798 Kourouma, Nana 62, 63 Lacroix, Céline 927 Kelly, Greg 910 Kitsa, Paluku 681 Kovacs, Colin 367 LaCrue, Alexis N. 213, 931 Kelly, Heather E. 104 Kiwuwa, Steven 189 Kovzun, Kuzma V. 170 Lafferty, Erin I. 1045 Kelly, Jane X. 295, 876 Klade, Christoph 1126 Kozar, Michael P. 880, 881, 882 Lage, Regina C. G. 643 Kelly, Rosmarie 589 Klap, Jaco 569 Kozarsky, Phyllis 401, 406 Laguna-Torres, V. A. 267, 268, 474, Kelly-Hope, Louise A. 979 Klarman, Molly 310 Kpoto, Louise 727 647, 987, 990, 996 Kempaiah, Prakasha 742 Klarmann, Ute 1102 Kramer, Ann 967 Laha, Thewarach 1130 Kengne, Pierre 720 Klei, Thomas R. 118 Kramer, Laura D. 1095, 1100 Lahiri, Pulak 482 Kennedy, Erin D. 708 Kleinschmidt, Immo 221 Kramer, Michael 730 Lakshmanan, Viswanathan 841 Kenrick, Nwodu 1021 Klion, Amy D. 332, 671, 1083, 1084 Kramer, Martin L. 166, 169 Lakwo, Tom 818 Keny, Villa 194 Klonoski, Joshua 583 Krause, Michael A. 1039, 303, 845 Lal, Renu B. 917 Kenya-Mugisha, Nathan 322 Kloos, Helmut 1051, 382 Krcmery, Vladimir 476 Lalloo, Umesh G. 738 Keogh, Carolyn L. 254 Knap, Nataša 286 Kremer, Michael 1060 Lambert, Lynn 939 Kester, Kent E. 1010 Knapp, Elisabeth 41 Kreps, Gary L. 457 Lamias, Mark 401, 406 Keven, John B. 255 Knight, Matty 1111, 698, 700, 701 Kreuder-Johnson, Chris 690 Lammie, Patrick 312, 331, 464, 659, Kevin, Barnham J. 847 Knox, Tessa 582 Krogstad, Donald J. 238, 601, 866, 814 Khairnar, Krishna 693, 871, 887 Ko, Albert I. 1136 875, 1043, 1088, 772, 889 Lamptey, Helena 914 Khalid, Nabila 60 Ko, Winston Wen-Chien 411 Kroidl, Inge 860 Lamunu, Margaret 727 Khamag, Haneen 408, 410 Kobayashi, Tamaki 543, 869 Krolewiecki, Alejandro J. 312 Lanar, David E. 1034, 1074 Khan, Ashraful Islam 323, 715, 716 Koch, Matthew 224 Kron, Michael A. 816 Lanata, Claudio F. 713 Khan, Dawlat 64, 288, 324, 725, 1106, Kochel, Tadeusz 267, 268, 292, 352, Kronmann, Karl C. 20, 270, 1073, Lanciotti, Robert S. 443 Khan, Farhat 938 427, 446, 474, 647, 651, 653, 654, 768, 729, 767 Lander, Eric 378 Khan, Gulam M. 835 987, 990, 995, 996, 998 Krudsood, Srivicha 1045, 853 Lander, Hollie 150 Khan, M.S.U. 288, 687 Kodikara-Arachchi, Wasantha 775 Krzych, Urszula 1010, 739, 740 Landis, Sarah H. 681 Khan, Sheik H. 727 Kodio, Aly 172 Ksiazek, Tom 294 Lane, Amanda 1001 Khan, Shahid M. 1036 Koech, Davy 745 Kuan, Guillermina 285, 94, 96 Lane, Robert S. 9 Khan, Wasif A. 1103 Kogelman, Laura 650, 997 Kubar, Ayhan 812 Laney, Sandra J. 1019, 670 Khanam, Farhana 1144, 1145 Koita, Ousmane A. 1043, 1088, 772 Kucerova, Zuzana 497 Lang, Jean 437 Khemawoot, Phisit 22, 298, 512, 896 Koivogui, Lamine 727 Kuchuloria, Tinatin 773 Langevin, Edith 395 Khodiev, Aybek V. 74 Koka, Hellen S. 392 Kuete, Thomas 1023 Langevin, Stanley A. 1120 Khore, Madhavi 919 Kokhreidze, Maka 754 Kuhen, Kelli L. 170, 507 Langoi, David 279 Khoury, Kareem 278 Kokwaro, E.D. 984 Kuhlmann, F. M. 125 Lankouande, Malick 934 Kiang, Richard 195, 265 Kolaczinski, Jan H. 458 Kuipers, Harmjan 1033 Lanteri, Charlotte A. 298, 873, 883 Kibet, Clifford 578 Kolappan, C. 1085 Kulmala, Teija 865 Lanzavecchia, Antonio 422 Kidwell, Mary Anne 561 Kolev, Nikolay 1153 Kumagai, Takashi 182, 380 Laquer, Kari M. 935, 937 Kiechel, Jean-René 301, 834 Kolhe, Priti 589 Kumar, Alexander 100 Largier, John 690 Kikuchi, Mihoko 837 Komaki-Yasuda, Kanako 212, 924 Kumar, Mukesh 1098 LaRocque, Regina C. 323, 715, 716, Kilembe, Bernard 450, 823 Komar, Nicholas 1096 Kumar, Nirbhay 543, 933 1144, 1145 Kilima, Peter 450 Kominek, Byron C. 1063 Kumar, Pavan 1085 LaRoux, Michele 378 Killmaster, Lindsay F. 413 Komisar, Jack 1079 Kumar, Rajesh 762, 763 Larsen, Peter A. 809 Kilpatrick, A. Marm 1100 Konate, Amadou T. 932, 934 Kumar, Santha 520 Larson, David 1080, 1082, 1086 Kilpatrick, C.W. 963 Konate, Bakary 856 Kumar, Sanjai 844 Larson, Peter S. 1117 Kim, Jung Yeon 926 Konaté, Drissa 1039, 845 Kumar, Vijay 762, 763 Laserson, Kayla 1027, 1141 Kim, Nimol 335 Konate, Mamadou 961 Kumaran, Paul 1085 Lasley, Jennifer 710, 821 Kim, Tae Im 273 Konate, Salimata 27 Kumaraswami, V 1085 Latham, Mark 652 Kim, Yohan 743 Konate, Siaka 113, 332, 1081, 1083, Kun, Jürgen F. 191 Lau, Rachel 871 Kim, Yeon Joo 926 1084 Kuntawungin, Worachet 858 Laucella, Susana A. 500 Kimmel, Rhonda 918 Kone, Abdoulaye K. 1042, 1074 Kunz, Susan 947 Laurens, Matthew 897, 1073, 1074 Kinabo, Grace D. 472 Kone, Mamady 1137 Kuritsky, Joel 399 Lawrence, Gena G. 419 Kines, Kristine J. 1127, 637 Kone, Moussa 526 Kurtis, Jonathan D. 379, 462, 99 Lawrie, Alison 1077 King, Charles 1051, 290 Kone, Mamady 541, 552 Kurtti, Timothy J. 49 Lawyer, Phil 481 King, Christopher 368 Kone, Penali L. 526 Kusriastuti, Rita 185 Laxminarayan, Ramanan 1057 King, Chwan-Chuen 802, 92 Kone, Younoussou 1007 Kvalsund, Michelle P. 82 Lay, Bibiana W. 76 King, Charles H. 1047, 45, 593, 639 Kongkasuriyachai, Darin 216 Kwak, Byung Kook 273 Lazar, Carmen 516 King, Christopher L. 336, 745 Kongmee, Monthathip 967, 970, 973 Kwansa-Bentum, Bethel 144, 182, Le Viet, Thanh 98 King, C.R. 1078 Kongsaeree, Palangpon 214 380 Leartsakulpanich, Ubolsree 214, 216 King, Christopher R. 743 Koninga, James 1065 Kwarteng, Alexander 1102 Leary, Kevin J. 67

240 Author Index The number(s) following author name refers to abstract number.

Lebo, Emma 73 Li, Xiaoming 985 Loret-de-Mola, Christian 657 Madaki, Aboi J. K. 304 Lebras, Jacques 7 Li, Yuesheng 1046 Loroño-Pino, María Alba 596, 644, Madarieta, Susana K. 803 Lebrun, Lauren M. 610, 716 Liang, Kaida-may R. 1063 1122 Maddox, Clinton 813 Lee, Cheng-Jung 802 Liang, Song 731 Loss, Scott 599 Madhubala, Rentala 36 Lee, Clarence M. 637, 701 Liang, Tian Z. 692 Loukas, Alex 1130 Madiyarov, Ruslan S. 74 Lee, John S. 754 Liang, Xiaowu 1007 Lounibos, L. Philip 243 Madrid, Cesar 995 Lee, M. 902 Liang, YanMei 346, 348 Lourenço-de-Oliveira, Ricardo 722 Madsen, Mark 483 Lee, Nayoung 536 Libraty, Daniel H. 355 Loussert, Céline 927 Maes, Peter 222 Lee, Pi-Yao 402 Liepinsh, Dmitry 739 Loutfy, Mona 367 Maestre, Amanda 206 Lee, Rogan 312 Liepman, Michael R. 103 Lovari, Robert 811 Magak, Ng’wena G. 203, 1025, 1031 Lee, Susannah 1068 Liles, W Conrad 343, 502, 848, 985, Lovegrove, Fiona E. 1045 Magill, Alan 155, 168, 297, 298, 550, Lee, Sue 858 1045 Lowenberger, Carl 229 750, 833 Lee, Yeuk-mui 310, 59 Lim, Hyeong-Seok 181 Loyevsky, Mark 897 Maguire, Jason D. 2 Lee, Youn-Jin 624 Lim, Pei-Yin 1095 Lu, Feng 867 Mahanty, Siddhartha 1081, 1083, Leenstra, Tjalling 462 Lim, Pharath 2 Luang, Khin M. 165 1084, 309 Leeper, Connie 904 Lim, Yvonne A. L. 477, 617 Luangtrakool, Komon 355 Mahapatra, Lily 1081 Leesoy, Lyndon 585 Lima, Aldo A. M. 1140, 75, 80, 81, Luangtrakool, Panpimon 355 Maharaj, Payal D. 1120 Legac, Jenny 377 82, 83 Lubega, George 41 Maharjan, Mahendra 36 Legler, Patricia 938 Lima, Ila F. N. 75, 80, 81 Lübke-Becker, Antina 72 Mahdy, Mohammed A. K. 477, 617, Legorreta-Herrera, Martha 930 Lima, Marli M. 1015 Luby, Stephen P. 1000, 1061, 1106, 695 Legrand, Anne-Marie 1019 Lima, Noélia L. 1140 288, 324, 64, 687, 725, 835 Maher, Steven P. 519 Legrand, Eric 335, 890 Lima-Neto, Jones B. 75 Lucas, Carmen M. 23, 529, 554, Maheu-Giroux, Mathieu 187 Lehane, Adele M. 890 Limbach, Keith 568, 570, 1009, 1078 657, 925, 942 Maiga, Hamma 149, 208 Lehmann, Tovi 588 Limbaso, Samson K. 392 Luchavez, Jennifer 860 Maikere, Jacob 222, 546, 678 Lehr, M. A. 963 Limpawattana, Panita 409 Lucke, Andrew 158 Maina, Geoffrey M. 1049 Leibly, David J. 170 Lin, Ai J. 298, 880, 881, 882 Luckhart, Shirley 1110, 230, 544, Maiolatesi, S 1078 Leissner, Philippe 1042 Lin, Baochuan 455 928, 956, 958 Maiteki-Sebuguzi, Catherine 1066 Leistner, Christine E. 974 Lin, Hsiao-Han 411 Lucy, Frances 691 Majalija, Sam 1142, 1143 Lejano, Jennylynn 571, 743 Lin, Jessica 22, 858, 896, 907 Ludolf, Fernanda 275 Makanga, Michael 854 Leke, Rose G. F. 139, 563 Lin, Ming 1122 Lugala, Peter C. 727 Makio, Albina 392 Leke, Rose G. and the team at the Lin, Po-Shu 402 Lugo-Yarbuh, Ana 131, 498, 827 Malagón, David 463 Biotechnology Center 846 Lin, Wanen 110 Lui, Jenbon 833 Malanoski, Anthony 455 Lekostaj, Jacqueline 530 Lindblade, Kim A. 1025 Lukat-Rodgers, Gudrun 844 The MalariaGEN Consortium 1109 Lemiale, Laurence 1032, 1073 Lindergard, L. Gabriella 374 Lum, Stephanie 1098 Malacela, E.K. 548 Lemnge, M.M. 548 Linthicum, Kenneth J. 578, 652 Lumley, Thomas 189 Malecela, Mwele N. 450, 823 Lemos, Elba R. S. 308 Liotta, Janice L. 692 Lumsden, Joanne 1010, 739 Maleta, Kenneth 865 Lena Juliette, Daher 560 Lipoldova, Marie 46 Lun, C .M. 699 Malhotra, Indu 368, 745 Lenin del Cuadro Hidalgo, Daniel Lisk, Godfrey 1108 Lungay, Victor K. 1065 Malik, Lankoande 903, 929 576 Liskova, Anna 476 Lungu, Chris 538 Malila, Aggrey 668 Leo, Elena 606 Listyianingsih, Erlin 76 Luntamo, Mari 865 Malisa, Allan 4 Lerdthusnee, Kriangkrai 974 Litilit, Dianne 571 Luong, Thu-Lan 873, 880, 882 Malkin, Elissa 1076 Lertora, Juan J. L.. 875 Liu, Canhui 675 Lurie, Perrianne 401, 406 Mallik, Arun K. 126 Lertwilairatanapong, Thongchai 326 Liu, Jun 151, 985 Lustigman, Sara 673 Maloney, Jenny G. 417 Lery, Leticia S. 495 Liu, Liang 816 Luswago, Luswa 1142, 1143 Mammen, Mammen P. 355 Lescano, Andres G. 1138, 445, 446 Liu, Pu 1008 Lutomiah, Joel 392 Mamuchishvili, Nana 773 Leski, Tomasz A. 455 Liu, Qiang 752 Luxemburger, Christine 354, 440 Mand, Sabine 1102, 824 Letendre, Scott L. 861 Liu, Xianjun 882 Luy, Betty 393 Manda, Hortance 600, 759, 973, 975 Letson, G. William 800 Liu, Yi 805 Lwamafa, D. K. W. 818 Mandal, Rima 482 Letson, W. W. 780 Lizak, Martin 309 Lwambo, Nicholas 823 Mandalasi, Msano 636 Letvin, Norman L 569 Llinas, Maneul 341 Lyimo, Thomas 664 Mandomando, Inacio 1070 Levin, Mariano J. 38 Loaiza, Jose 718, 722 Lyke, Kirsten E. 1074, 744, 897 Manetsch, Roman 519 Levin, Michael L. 413 Lobo, Neil F. 961, 964 Lynch, Julia 426, 786 Mann, Victoria H. 1127 Levine, Myron 62, 63, 85, 1141 Lococo, Bruno 500 Lynch, Penelope A. 579 Manning, Jessica E. 1042, 1107 Levy, Michael Z. 484 Logvinenko, Tanya 1145 Lynn, Rasmussen 813 Mannix, Frank 585 Lewandowski, Henry B. 652 Loker, Eric S. 699, 703, 1049 Lyons, Arthur 784 Manong, Doris 24, 307 Lewis, Fred 698 Lokomba, Vicky 224 Lyons, Emily 1030 Manoukis, Nicholas C. 598, 972 Lewis, Sheri 717, 1005, 111 Lon, Chanthap 22, 858, 896, 907 Mansour, Adel M. M. 712 Leyk, Stefan 717 Londono, Berlin L. 238, 601, 866 M Mansurov, Z. N. 404 Li, Benwen 124 Long, Carole A. 344, 565, 845, 1039, Mante, Sunny D. 330 Li, Fengwu 1115, 317 1067, 1075, 1076 Ma, Wu 838 Mantel, Nathalie 394 Li, Feng 811 Long, Kanya C. 976 Mabunda, Samuel J. A. 221 Manyando, Christine 505 Li, Hongwei 950 Loo, Jennifer D. 735 Macareo, Louis R. 165 Mapue, Manuel 585 Li, Ling 373, 857 Looareesuwan, Sornchai 1045 MacArthur, John R. 4 Maranich, Ashley M. 426 Li, Meng 953 Lopera-Mesa, Tatiana M. 1039, 845 Macete, Eusebio 160, 1070 Marano, Nina 401, 406, 650, 997 Li, Qigui 67, 161, 162, 163, 164, Lopez, Cecille 585 Machado, Paula R. Lima 93, 291 Marcet, Paula L. 756 298, 750, 873, 880, 881, 882 Lopez, Gabriel 763 Machado, Paulo R. L. 831, 832 Marchito, Maxwell 321 Li, Qi 950 Lopez, Job 11 Maciel-de-Freitas, Rafael 251 Marcos, Luis A. 271 Li, Robert 1046 Lopez, Victor 759, 975 Mackenzie, Charles D. 120, 331, Marfo-Debrekyei, Yeboah 1102 Li, Wei 604 Lord, Cynthia C. 391 450, 823 Margolis, Harold S. 399, 780, 800 Li, Xia 262 Lorenzana, Ivette 987 MacLeod, William 650, 732 Mariama K., Charrif 915

241 Author Index The number(s) following author name refers to abstract number.

Marie, Jerome 1019 McCall, Suzanne 612, 613 Mesquita, Daniel L. 989 Mmbando, Donan 450 Marin, Dairo 253 McCalmont, William F. 298, 873, Messer, William 790 Mmbuji, Peter 450 Marinotti, Osvaldo 361, 962 874, 883 Messina, Janey 1026 Mohan, Andrea R. M. 607 Marins Povoa, Marinete 860 McCarra, Matthew 1031 Mestra, Alberto 65 Mohan, Michael J. 344 Marjason, Joanne 1076 McCarthy, James S. 860, 1076, 299 Metenou, Simon 1081, 1083, 1084 Mohan, Subburaman 379 Marks, Florian 211 McClellan, Holly 561 Mett, Vadim 1038 Mohareb, Emad W. 648, 649 Maro, Athanasia 629 McClelland, Michael 1145 Mettens, Pascal 1032 Mohd-Adnan, Adura 617 Maro, Venance P. 365, 629 McCollum, Andrea M. 23, 3, 529, 925 Metz, Kyle 483 Mohr, Sharif 1136 Marovich, Mary A. 33, 430 McElnea, Catriona 97 Meya, David 322, 471 Moke, Fenny 1141, 85 Marques, Ernesto 353 McElroy, Peter 664 Meyer, Jason 49, 1014 Molaei, Goudarz 388, 389 Marra, Peter P. 1100 McFarland, Deborah 105, 444, 448, Meymandi, Sheba K. 408, 410 Molina, Darjaniva 584 Marrast, Anne-Claire 504, 853, 854 453, 640 Meza, Rina 657, 713, 78 Molina, Douglas M. 1007 Marron, Jennifer A. 396 McGarvey, Stephen T. 379, 462, 99 Meza, Yocelinda 79 Molina-Cruz, Alvaro 237, 595 Marsh, Kevin 1069 McGee, Charles E. 976 Mharakurwa, Sungano 543 Moll, Anthony P. 738 Marshall, John M. 1116, 360 McGrath, Shannon 743 Miagkov, Alexi 415 Molyneux, Malcolm E. 1041 Martensson, Andreas 177, 183 McGready, Rose 136, 26 Michael, Edwin 1022, 450, 823 Monath, Thomas P. 1099 Marti, Matthias 143 McHenry, Amy 336 Michael, Kramer 609, 705 Moncayo, Abelardo C. 417, 761 Martin, Diane 189 McKay, Courtney 229 Michalski, Shelly 123 Mondal, Dinesh 315, 766 Martin, Donald S. 871 McKellip, Sara 610 Michaud, M. Robert 15 Mondal, Utpal K. 288 Martin, John 674 McKenzie, F. Ellis 342, 979 Michee, Kabera 609, 705 Montalvan, Carmen 23, 529 Martin, Maureen P. 917 McKeon, S. N. 963 Michon, Pascal 1071, 911 Montazeri, Sayed M. S. 60 Martinelli, Axel 335 McLean, Jeremy E. 857 Miesfeld, Roger 946, 947, 948, 949 Monteiro, Gloria R. 39 Martínez, Javier 886 McLellan, Duncan 68 Miguel, Edward 1060 Montenegro, Lidia 886 Martinez, Luis J. 426 McManus, Donald P. 1046, 55 Mikoleit, Matthew 1142 Montgomery, Brian 435 Martinez, Raymond 689 McMorrow, Meredith 676, 864 Miller, Andre 1111, 698, 700, 701 Montgomery, Jacqui 143 Martínez, Ruth A. 778 McNulty, Samantha N. 674 Miller, David 1016 Montgomery, Joel 111, 292 Martinez-Gutierrez, Marlen 432 McQueen, Philip G. 342 Miller, Joanna 428 Montgomery, Joel M. 1138, 445, Martinson, Jeremy 140, 142, 555, 556 McWilliams, Ian 1034 Miller, John M. 866 446, 657 Martiradonna, Gianna 584 Mead, Daniel 589, 761 Miller, Lori 550 Montgomery, Susan P. 56, 634 Martyn, Derek 536 Mease, Ryan M. 935, 937, 938 Miller, Louis H. 541, 552, 561, 565, Montoya, Rosario 260, 261, 605 Mas-Coma, Santiago 223, 702 Meays, Diana 843 939, 1007, 1038, 1075, 1137 Moon, James 550 Masanja, Honorati 668 Medana, Isabelle M. 137 Miller, Melissa 690 Moon, Joung-Ho 623, 626 Masanja, Irene 676 Medeiros, Márcia M. 193 Miller, Mark 717 Moon, Jay K. 873 Masanja, M. Irene 864 Medina, Freddy A. 34 Miller, Melissa M. 954 Moonasar, Devanand 540 Mashinski, Yessika 691 Meeks, Heather N. 809 Miller, R. Scott 550, 67 Moonga, Hawela B. N. 866 Mason, Carl J. 74, 711 Meeks, Janet 30, 91 Miller, Robert M. 300, 517 Moore, Blake 813 Massey, Chad 238 Meheus, Filip 830 Miller, R. S. 165 Moore, Brioni R. 508, 510 Massougbodgi, Achille 145 Mehta, Ishita S. 1111 Milligan, Paul 509 Moore, Christopher C. 322, 471 Masuoka, Penny 970 Mehus, Joseph O. 256 Mills-Robertson, Felix C. 77 Moore, Jerrilynn L. 977 Mateo, Lynette 97 Mekonnen, Alemayehu 1062 Millum, Joseph 1137 Moore, Sean R. 1140, 83 Mathanga, Don P. 1117 Melby, Peter C. 480, 661, 749 Milner, Erin 873, 883 Moorhead, Andy R. 822 Mather, Frances J. 875 Melendez, Astrid X. T. O. 1136 Milner, Jr., Danny 143, 378 Moormann, Ann M. 199, 918 Mathieu, Els 112, 1134, 114, 115, 329, Melendez, Esperanza 604 Mimche Nsangou, Patrice 150 Mora, Matias S. 756 708, 710, 821 Melendez, Victor 163, 295, 298, 512, Mimpfoundi, Rémy 575 Moraga, Berman 96 Mathison, Blaine A. 466, 56, 627 67, 873, 880, 881, 882, 883 Min, Xinan M. 199 Morahan, Belinda J. 316 Mathur, Geetika 962 Meleshkevitch, Ella A. 954 Min-Oo, Gundula 877, 985 Morais, Cristiane G. 200 Matoso, Leonardo F. 1051, 382 Melrose, Wayne D. 814 Minakawa, Noboru 51, 246 Morales, Alba Lucia 1024 Matthews, Scott 763 Meltzer, Martin I. 399 Ming, Xin 752 Morales, Maria E. 1127, 637 Matthias, Michael A. 1146 Membi, Christopher 860 Mintardjo, Ratna 1033, 569 Moran, Mary 1135 Mattia, Kimberly-Anne 431 Menard, Didier 860 Mintz, Eric 85, 1141, 1142, 1143 Moreno, Elio 131, 498, 827 Matute, Juan Carlos 96 Ménard, Robert 927 Minz, Shantidani 459 Moreno Leirana, Marta 722 Maude, Richard J. 135, 523 Mende, Katrin 269 Miranda, Jaime 311 Moreno- Fierros, Leticia 930 Mave, Vidya 875 Mendez, Juan 750, 833 Miri, Emmanuel 448, 453, 640, 1021, Morens, David M. 109 Maves, Ryan C. 1138, 446, 657, 713, Mende, Katrin 611 116 Mores, Christopher N. 978, 983 768, 78, 79 Mendoza, Ana Patricia 292 Mitchell, Robert 1035 Moretz, Samuel E. 1067, 565 May, Juergen 211 Mendoza, Alfonso 520 Mitchell, Tarissa 645 Morgah, Kodjo 1134, 114 Mayalla, Benjamin 823 Mendoza, Alberto 606 Mitre, Edward 1080, 1082, 1086 Morgan, Marjorie S. 8, 753 Mayanja-Kizza, Harriet 322, 471 Mendoza-Silveiras, J 1078 Mitreva, Makedonka 118, 674 Moris, Philippe 1010 Mayda, Maria E. 386, 757 Menendez, Clara 1070 Mitta, Guillaume 280 Morlais, Isabelle 362, 720 Mayers, Gillian F. 735 Menge, David M. 1025, 906 Mittelholzer, Christian 1034 Morrill, Westin 876 Mayor, Alfredo 1070 Menon, Sanjay 532, 533 Mitter, Sumeet S. 82, 83 Morrison, Amy C. 352, 586, 654, 759, Mazet, Jonna K. 690 Mera y Sierra, Roberto 702 Mitu, Simona 516 798, 975, 995 Mazier, Dominique 1036 Mercado, Erik 713, 922 Miura, Kazutoyo 1075, 552, 565, 939, Morrissey, Anne B. 365, 472 Mazitschek, Ralph 169, 536, 878 Mercado, Juan Carlos 94, 94, 96 944 Morton, James 949 Mbewe, Bernard 865 Mercer, Luke 132, 748 Mixson-Hayden, Tonya 3 Moses, Bockarie J. 1022 Mbogo, Loice 371 Mercereau-Puijalon, Odile 335, 890 Miyahira, Yasushi 551 Moses, Lina 601, 727, 1065 Mboup, Souleymane 378 Meseko, Clement A. 287 Mizumoto, Carla 69 Mosher, Aryc 538, 1021 Mbugi, Jenard 249 Meshnick, Steven Mkandawire, Rhoda 505 Mosites, Emily 314 McArthur, Julie H. 396 Meshnick, Steven R. 2, 224, 303, 667, Mkoji, Gerald M. 1049 Mosqueira, Beatriz 223 McCall, John W. 817 681, 852, 865, 921, 1026 Mmbando, B. 548 Moss, Kelly 785

242 Author Index The number(s) following author name refers to abstract number.

Moss, William J. 347, 543, 869, 885 Mutuku, Martin W. 1049 Necochea, Alejandro 261, 605 Nuriyev, Tahir 1001, 451 Mota, Javier 357 Mutumanje, Elissa 608 Neil, Karen 1142, 1143 Nutman, Thomas B. 312, 332, 671, Mota, Rosa M. S. 75, 81, 82, 83 Muwonga, Jeremie 1026 Nelson, Steevenson 95 672, 820, 1081, 1083, 1084, 1085 Mounsey, Kate 8 Muyembe, Jean-Jacque 289 Nemeth, Nicole 1121 Nwane, Philippe B. 575 Moura, Hercules 495 Mwakitalu, Mbutolwe E. 450, 823 Nerurkar, Vivek R. 1098, 86, 91 Nyakoe, Nancy 544 Moyo, Evance 1055 Mwako, Mtumwa S. 365 Newman, M. S. 188 Nyame, A. K. 636 Mpabalwani, Evans 505 Mwalabu, Elias 1055 Newman, Patrick C. 1004 Nyandindi, Ursuline 450 Mpanga Sebuyira, Lydia 305 Mwangi, Ibrahim N. 1049 Newman, Patrick M. 537 Nyarko, Alexander 913 Msuya, Levina 472 Mwapasa, Victor 667, 921 Neyra, Joan 111 Nyarko, Edward 270, 767 Mtonga, Euphrasia 732 Mwetse, Nyangui B. 772 Neyra, Victor 923 Nygren, Benjamin L. 85 Mu, Jianbing 303 Mwingira, Upendo 450, 823 Ng’nonga, Daniel 578 Nylander, Francis 727 Muchiri, Eric M. 45, 368, 593, 745, Mwinzi, Pauline N. M. 346, 381, Ng’wena, Gideon M. A.. 204 Nyunt, Myaing M. 859 1028, 1047 634 Ngasala, Billy 680 Nzarubara, Bridget 1066 Mudeppa, Devaraja G. 338, 373 Myers, Jocelyn 700, 701 Ngassam, Pierre 720 Muehlenbachs, Atis 1040, 136 Myers, Todd E. 754 Ngere, Francis 578 O Mueller, Brandi A. 424 Myint, Hla Y. 155 Ngondi, Jeremiah 538 Mueller, Ellen 1080, 1086 Myint, Khin S. A. 994 Nguku, Patrick 294 O’Brien, Kathryn 95 Mueller, Ivo 1071, 24, 307, 375, 510, Myrie, Latoya 368 Nguyen, Andy M. 254 O’Guinn, Monica L. 754 910, 911 Mzayek, Fawaz 875 Nguyen, Lam Ngoc 1019 O’Hara, Geraldine 1077 Mueller, Norbert 1101 Mzyangizyangi, Honesta 668 Nguyen, Phuc G. 344 O’Neil, Michael T. 295, 527, 874, Mugyenyi, A. 487 Nguyen Thi Thanh, Thuy 98 880, 1079 Muhimpundu, Marie-Aime 730 N Nhabomba, Augusto J. 160 O’Reilly, Ciara E. 85 Muhle, Rebecca 522 Nhampossa, Tacilta 1070 O-tipo, Shikanga 1142, 1143 Muiruki, David 547 N’Dong, Christelle 208 Niang, Makhtar 335 O`Reilly, Ciara E. 1141 Muiruri, Samuel 45 N’Goran, Eliézer K. 1029 Niangaly, Amadou 1042, 1074 O’Loughlin, Rosalyn E. 735 Mukabayire, Odette 730 Nabasumba, Carolyn 26 Nicholson, William L. 413 O’Neil, Paul A. 587 Mukherjee, Angana 36 Nacer, Adéla 1035 Nickley, Katherine B. 511 O’Reilly, Ciara E. 1062 Mukhtar, Ahmed 222, 546, 678 Nadesakumaran, Kogulan 255 Nicolai, Cecília C. A. 308 Obata, Kazushige 380 Mukhtar, Izdihar 175 Nagahawatte, Ajith 775 Nicosia, Alfredo 1077 Obregon, George 606 Mukobi, Peter 1142, 1143 Nagajyothi, FNU 496 Nimmo, Derric 358, 580, 967 Ocampo, Clara 253 Mulama, David H. K.. 198 Nagata, Kyosuke 212 Ning, Yao 282 Ocan, Samuel 305 Mulaya, N. 984 Nahar, Nazmun 288, 324, 687 Nisalak, Ananda 796 Ocaña, Victor R. 78, 768, 987 Muliyil, Jayaprakash 459 Nahlen, Bernard 917 Njama-Meya, Denise 1066 Ochieng, Benjamin 1141, 73, 85 Mullainathan, Sendhil 1060 Nahum, Laila 274 Njau, Joseph D. 1054 Ochoa, Theresa J. 713 Mulokozi, Abdunoor 4 Nair, Shalini 532, 533 Njenga, Kariuki 294 Ochola, Lyticia V. 204 Mulumba, Madishala P. 485 Nakandakare, Gianni 111 Njideka, Okpala T. 1021 Ochuko, Keyamo A. 868 Mulvenna, Jason 1133 Nakaya, Helder 643 Njogu, Julius N. 71 Ockenhouse, Christian F. 570, 571, Mundal, Kirk D. 446, 759, 942, 975 Nakhasi, Hira L. 491 Njuguna, Henry N. 73 743, 902, 935, 942, 1009, 1032, Mungai, Ben N. 1049 Nalapa, M. 487 Njunju, Eric 505 1078, 1079 Mungai, Peter L. 368, 593, 745, Namagembe, Allen 305 Nkhoma, Ella T. 303 Ockenhouse, Eric B. 902 1047 Namayanja, Monica 41 Nkogho, Oluchi 154, 855 Odeny, L. 984 Munk, A. Chris 414, 616 Namountougou, Moussa 252, 573 Nkrumah, Francis 225, 549, 669 Odera, Michael M. 201 Munoz, Benito 166 Nanayakkara, N. P. Dhammika 296 Nnedu, Obinna N. 872 Odette, Mukabayire 705 Muñoz-Jordán, Jorge L. 34, 354, Nankabirwa, Joaniter I. N. 71 Noah, James W. 610 Odhiambo, Moses 1053 394, 788 Nanteza, Ann 41 Noden, Bruce H. 587 Odhiambo, Ojera 984 Munstermann, Leonard E. 253, 724 Napuli, Alberto J. 170 Noe, Andy 132, 748, 829 Odoemelan, Edwin C. 1111 Muok, Erick M. O. 381 Náquira, César 484 Noedl, Harald 894 Odoi, Agricola R. 592 Muratova, Olga 1038, 562 Narathipput, Jariya 326 Noh, John 310, 59 Odoom, Shirley 20, 270, 767 Murillo, Claribel 532, 533, 886 Nardin, Elizabeth 1035 Noiri, Eisei 835 Odor, Livinus L. 302 Murillo Solano, Claribel 178 Nare, Bakela 132, 748, 829 Noisakran, Sansanee 441, 90 Odour, Margaret 544 Muriuki, David 870 Narum, David 911, 939, 1007 Nolan, Bill 125 Oduola, Ayo 515 Murphy, Brian R. 396, 397 Narvaez, Federico 423 Noland, Gregory S. 199, 203, 204 Oduola, Ayoade M. J. 521, 531, 868 Murphy, Jitta 1079 Nash, Theodore 309 None, Konate A. T. 903 Oduro, Abraham R. 225, 549, 669 Murphy, Vince J. 847 Naskar, Rima 482 Noor, Abdisalan M. 1028 Offi anan, Toure A. 526 Murray, Clinton K. 269, 611, 612, Nasser, Shereen 150 Noor, Zannatun 766 Ofori, Micheal 913 613 Natarajan, Jayakumar J. 524 Noordin, Rahmah 709 Ofori-Anyinam, Opokua 1010 Murray, Meridith R. 431 Nataro, James P. 75, 80, 84, 85, Norante, Francesca 697 Ofulla, Ayub V. 142, 204 Musapa, Mulenga 18 1141, Norris, Douglas E. 18, 19, 971 Ogola, Bilha S. A. 203 Mushatt, David M. 875 Nathaniel-Girdharrie, SueMin 101 Norris, Laura C. 18, 19, 971 Ogonda, Lilian A. 202 Musiychuk, Konstantin 1038 Navarro, Juan C. 960 Nosten, Francois 26, 136, 165, 523, Oguike, Mary C. 138 Muskus, Carlos 206 Nawaratna, Sujeevi 1133 853 Ogunfowokan, Oluwagbenga P. 302 Musset, Lise 890 Ndao, Momar 782 Novelli, Jacopo 1112 Ogunkunle, Oluwatoyin 850 Mutabingwa, Theonest K. 1040, 136 Ndege, Henry O. 142, 555 Ntep, Marceline 1023 Ogutu, Bernhards 301, 544, 860, Mutalemwa, Prince 823 Ndenga, Bryson A. 249 Ntumngia, Francis B. 1072 1073 Muth, Sinuon 2 Ndo, Cyrille 720 Nuchprayoon, Surang 117 Ogutu, David 818 Mutheu, Julliette 192 Ndubuisi, Mackevin 621 Nuckols, John 717 OhAinle, Molly 351 Muthoni, Milka 392 Neafsey, Daniel 378 Null, Clair 1060 Ohrt, Colin 155, 168, 297, 298, 512, Mutisya, James 392 Neal, Aaron T. 559 Nundlall, T. Ram 540 550, 880, 884 Mutka, Tina 515 Nebane, Miranda 610 Nuñez, Andrea 423, 94 Ohta, Nobuo 182, 380 Mutuku, Francis 593 Nébié, Issa 932, 934 Nuñez-Ayala, Guadalupe 596 Ojaku, Alex 305

243 Author Index The number(s) following author name refers to abstract number.

Ojo, Linda R. 735 Osorio, Jorge E. 393, 432, 787, 791, Panchalingam, Sandra 1141 Perera, Suwani 565 Okatcha, Tunika I. 1127 794, 795, 797, 801, 992 Pandey, Basy D. 126 Perez, Daniel 801 Okedi, Loyce 487 Osorio, Lyda 178, 532, 533 Pandey, Kishor 126 Perez, Juan 647, 768, 79 Okell, Lucy C. 1030 Ospina, Marta 432 Pangesti, Krisnanur A. 737 Perez, Mary C. 498 Okenge, Augustin 1026 Oster, Robert A. 943 Panicker, Rajashree 1057 Perez, Taonex 1096 Okine, Rafi q 914 Ostera, Graciela R. 844 Panka, Rungnapa 1081 Pérez-Guerra, Carmen L. 776, 777 Okiro, Emelda A. 192 Osterbauer, Beth 989 Pantoja, Petraleigh 429 Pérez-Mazliah, Damián 500 Okitoi, M. 487 Ostroff, Stephen 401, 406 Paoaafaite, Tuterarii 1019 Pérignon, Jean-Louis 205 Okonji, Caleb 1141 Otchere, Joseph 277, 314 Papin, James F. 783 Perkins, Douglas J. 140, 141, 142, Oksov, Yelena 673 Oteino, Michael F. 141 Parekh, F. 1078 553, 555, 556, 557, 742 Okuboyejo, Titilope 154, 855 Otero, II, Nenito D. 803 Parham, Robin 748 Perng, Guey Chuen 441, 90 Okumu, Fredros O. 250 Othoro, Caroline 917 Park, An Na 770 Perrigoue, Jacqueline 1149 Okuwaki, Mitsuru 212 Otiende, Moses Y. 207 Park, Bborie K. 980 Perumalpillai-McGarry, Meera 1133 Oladokun, Agnes T. 287 Otieno, Juliana 917 Park, Danny 378 Peruski, Leonard 615, 993 Olekszak, Haiyan 91 Otieno, Lucas 544 Park, Gregory S. 849 Perwitasari, Dian 420 Oliveira, Ana L. 559, 943 Otieno, Leonard 73 Park, Inho 926 Pesko, Kendra 416 Oliveira, Fabiano 481 Otieno, Michael F. 202 Park, Jae-Won 181 Peters, Bjoern 743 Oliveira, Guilherme 274, 275, 276, Otieno, Peter 1027 Park, Mahin 621 Peters, Jennifer 534 283, 643 Otsuki, Hitoshi 372, 562 Park, Sarah Y. 313 Peters, Ryan J. 1100 Oliveira, Livia S. 1015 Ottendorfer, Christy L. 1002, 969 Parker, Tina 269 Petersen, Christine A. 483 Oliveira, Rosana M. 781 Otuonye, Ngozi M. 655 Parker, Zahra 386, 757 Petersen, Ines 891 Oliveras, Elizabeth 288 Ou, Ruguang 213 Parriott, Sandi K. 1130 Petit de Peña, Yaneira 828 Olliaro, Piero L. 633, 677, 706, 747, Ouari, Ali 252 Parsons, Michele 1141 Petri, Jr., William A. 315, 766 830 Ouattara, Amed 566 Partidos, Charalambos D. 393, 787, Petzold, Max 680 Olmeda, Raul 880, 881, 882, 883 Ouedraogo, Alphonse 932, 934 791, 992 Peyton, David H. 876 Olowe, Adekunle O. 72 Ouedraogo, Amadou 704 Parveen, Shahana 1106, 64, 725 Phares, Christina 645 Olsen, Vicki 289 Ouedraogo, Amathe 932 Parzy, Daniel 1059, 7 Phasomkusolsil, Siriporn 244 Olson, Courtney L. 99 Ouedraogo, Andre L. 932 Pasay, Cielo 8 Philip, Trudy L. 717 Olszewski, Kellen A. 341 Ouedraogo, Espérance 932, 934 Passos, Luzia M. R. 781 Philius, Gabrielle 708 Olugbile, Sope 1008, 206 Ouedraogo, Jean-Bosco 252, 573, 377 Patel, Samir 1044 Phillips, Anna E. 1052 Olveda, Remigio M. 379, 462, 99 Ouma, Collins 140, 141, 142, 553, Patel, Vishal 169, 878 Phillips, Carlton J. 809 Omala, Hillary 73 555, 556, 557, 742 Patil, Anand P. 184, 185 Phiri, Kamija S. 667 Ombok, Maurice 294, 85 Ouma, John H. 745 Patra, Kailash P. 861 Phone Kyaw, Myat 860 Omore, Richard 1141, 85 Oundo, Joseph 1141 Patrick, A. 487 Phu, N.H. 1109 Omosun, Yusuf O. 917 Ouologuem, Dinkorma 208 Patrick, Peter D. 82 Piche, Claude A. 795 Omwangangye, Priscilla A. 305 Oviedo, Milagros J. 584, 828 Patrocínio, Paola 275 Pichyangkul, Sathit 1032 Ondeng, Alex 1141 Oviedo-Meza, Rodrigo 930 Pattanapanyasat, Kovit 205 Picot, Stephane 153, 27, 839 Ong, SuFey 475 Owais, Aatekah 102 Patterson, Noelle 568, 570 Piel, Fred B. 184 Ong’echa, John M. 140, 141, 142, Owens, S. Michele 475 Patterson, N. B. 1078 Pieniazek, Norman J. 466 553, 555, 556, 557, 742 Owusu-Opoku, Stephen 77 Pau, Maria Grazia 569, 1033 Pierce, Mark 541, 552, 1137 Ongoiba, Aissata 1007 Oyedeji, Segun I. 191 Paul, Jaishree 618 Pierce, Susan K. 1007 Onguru, Daniel 346 Oyibo, Wellington 860 Paupy, Christophe 719, 957 Pierro, Dennis 396, 397 Onifade, Dami 260, 605 Ozkul, Aykut 812 Pava, Zuleima 886 Pierson, Theodore C. 95 Onlamoon, Nattawat 441, 90 Ozoh, Gladys A. O. 328 Pavlin, Julie A. 994 Pike, Andrew D. 364 Ono, Takeshi 551 Ozyurt, Mustafa 628 Pawlowiez, Ralph 1019 Pilingana, Portipher 732 Onwuliri, Celestine O. E. 197 Paz-Soldan, Valerie 352, 798 Pillai, Ajay D. 147, 337 Onyamboko, Marie A. 224 P Pazoles, Pamela 1099 Pillai, Dylan R. 159, 693, 871, 887 Ooi, Winnie W. 650, 771, 997 Pearl, Erika 112 Pimenta, Paulo F. P. 755, 758 Opika, Robert O. 345 Paaijmans, Krijn 981 Pearson, Richard D. 39 Pimentel, Guillermo 269, 270, 767, Opintan, J A. 84 Pacek, Martin 1144 Peaty, Laura F. A. W. 503 773 Opoka, Robert O. 849, 863 Pacheco, Rosa 492 Pedersen, Michael S. 582 Pinjari, Jakir 166 Oporto, Patricia 130 Pacheco-Yepez, Judith 620 Pelecanos, Anita 860 Pinkerton, Relana C. 322, 1140 Orago, Alloys S. S.. 202 Padilla, Carlos 920 Pelleau, Stéphane 7 Pinto, João 335 Ord, Rosalynn L. 904 Padilla Garcia, Eva 408, 410 Pelletreau, Sonia 710 Piola, Patrice 26 Ore, Marianela 657 Paessler, Slobodan 685 Pelton, Stephen I. 997 Piraliyev, Saleh 1001, 451 Oreagba, Ibrahim A. 148 Page, Connie 345 Peña, Marisol 776 Plasai, Valaikanya 242 Oria, Reinaldo B. 82, 83, 630, 1140 Page, Heidi 290, 293 Peña-Orellana, Marisol 439, 789 Plattner, Jacob 132, 748, 829 Orimadegun, Adebola E. 70 Page-Sharp, Madhu 508, 510 Penali, Louis K. 665, 901 Pleeter, Perri G. 530 Orinda, George 141 Paguio, Michelle F. 524 Pendyala, Prakash 857 Plichart, Catherine 1019 Orito, Yuki 927 Paidi, Maya 424 Peniche, Alex G. 749 Ploemen, Ivo 1036 Orozco, Miguel 474 Painter, John 645 Penna, Gerson O. 832 Plouffe, David M. 507 Orr, Matthew 132, 748, 829 Pak, Edwin 652 Pennington, Pamela 760 Plowe, Christopher Ortega, Corrie 237, 595 Pakpour, Nazzy 230, 956 Pepi, Deni 420 Plowe, Christopher V. 566, 744, 897, Ortega, Oscar 96 Palacios, Diva 238, 601 Perales, Renzo 127 1042, 1073, 1074, 1107 Ortega, Ynes R. 658 Palatulan, Eugene 891 Peralta, Jose M. 495 Poche, Richard 1016 Ortigao, Marcelo 483 Palekar, Rakhee 730 Peralta, Regina H. S. 495 Poeu, Sok 22, 858, 896 Ortiz, Jaime 736 Palihawadana, Paba 780 Pereira, Daniele N. 989 Polhemus, Mark 426, 544, 935, 1032, Osanya, Alex 40 Palmer, Dupeh R. 786 Pereira, J. B. L. 963 1079 Osario, Lyda 860 Palmieri, James R. 400, 619, 622, 696 Pereira, Marcus 520 Pollack, Henry J. 469 Osorio, Elvia Y. 661, 749 Pamplona, Paula 82 Pereira, Rosiane A. Silva. 643 Pollack, Stephanie 428

244 Author Index The number(s) following author name refers to abstract number.

Pollissard, Laurence 398, 440 R Reis, Renato B. 1136 Roach, Richard R. 103, 769 Polsomboon, Suppaluck 17 Reisen, William K. 387, 980 Robert, Willie 1065 Polyakova, Larisa A. 1016 Raballah, Evans 141 Reisenman, Carolina E. 419 Roberts, David 205 Ponces Freire, Ana 490 Rabinowitz, Joshua D. 341 Reiter, Karine 939 Roberts, Jacquelin 627 Pond-Tor, Sunthorn 379 Rack, Ralph H. 1055, 156, 219 Reithinger, Richard 538 Roberts, Renee 213 Ponnusamy, Loganathan 602 Raczniak, Gregory 20, 270, 767 Religa, Agnieszka 1148 Robinson, Cathy A. 578 Pontavornponyo, Wirichada 523 Radoševic, Katarina 569, 1033 Reller, Megan E. 682, 775, 869 Robinson, Jaimie S. 443, 804 Pontes, Nubia N. 39 Radtke, Andrea J. 1006 Ren, Suping 35 Robinson, Lauren K. 414 Pookit, Sopida 993 Raffel, Sandra J. 11 Renom, Montse 160 Roble, Noel D. 803 Poole, Charles 852 Raghavan, Nithya 1111, 698 Renslo, Adam R. 749 Roca, Yelin 998 Pornthanakasem, Wichai 216 Rahman, Bassem A. 269 Restrepo, Berta N. 797 Rocha, Crisanta 423 Portela, Julien 280 Rahman, Johanna E. 726 Restrepo, Lina 794, 797 Rocha, Claudio 654, 995 Porter, Kimberly A. 852 Rahman, Mustafi zur 1106 Restrepo Jaramillo, Bertha Nelly Roche, Aubree J. 413 Porwollik, Steffen 1145 Rahman, Mahmudur 324, 64, 725, 801 Roche, Claudine 30 Posner, Gary H. 151 1106 Reuhlen, Nevada 1064 Roche, J. K. 84 Postigo, Jorge R. 130 Rahman, Taibur 1144 Rewerts, Cindy 748, 829 Rocheleau, Thomas A. 235 Poussard, Allison L. 685 Rajan, Latha 188 Rey, Gloria 990 Rodenbough, Philip P. 170 Póvoa, Marinete M. 528, 722, 965 Rakers, Lindsay 1021, 1023, 818 Reyburn, Hugh 365, 472, 898 Rodgers, Kenton 844 Powell, Tim D. 393, 787, 791, 992 Ramadhani, Habib O. 365, 472 Reyes, Miguel 96 Rodrigues, Janneth 237, 595 Pozo Suclupe, Edwar 942 Ramal Asayag, Cesar J. 478 Reyes, S. 1078 Rodrigues, Laura C. 452 Prachumsri, Jetsumon 1079 Ramamurty, Nalini 443, 804 Reyes-Sandoval, Arturo 1077 Rodríguez, Ariane Rodríguez 569, Pradines, Bruno 7 Ramanathan, Roshan 312 Reyes-Solis, Guadalupe C. 583, 1033 Prado Izaguirre, Monica J. 960 Ramasamy, Gowthaman 373 1091 Rodriguez, Hugo 227 Prado Torres, Lindsay 905 Ramey, Kiantra I. 497 Reynolds, Donna 395 Rodriguez, Nilda E. 660 Prapansilp, Panote 137 Ramirez, Juan 606 Reynolds, Steve 471 Rodriguez, Richard 736 Prestwood, Tyler R. 793 Ramirez, Jose L. 792 Reynolds, Steven J. 322 Rodríguez, Rosa 789 Prichard, Roger 120, 41, 464 Ramirez, Marta 827 Rhee, Kyu 841 Rodriguez, Silvia 310, 311, 59 Prigge, Sean T. 842 Ramirez, Ruth E. 794 Ribeiro, Isabela 746, 834 Rodriguez-Barraquer, Isabel 353 Printy, Erin L. 1063 Ramirez-Sierra, Maria Jesus 21, 50 Ribeiro, Jose Marcos 945 Rodriguez-Henriquez, Francisco Privor-Dumm, Lois 735 Ramkissoon, Vernie 689 Ribeiro, Jose M. C. 598, 961, 972 427 Puerto, Fernando 644 Ramos, Eric 734 Ricaldi, Jessica 1146 Rodriguez-Madoz, Juan R. 788 Puffer, Bridget A. 431 Ramos, Mary 354 Richard, Stephanie 329, 329, 821 Roe, R. M. 48 Puma, Lwipa 505 Ramos, Mariana 657 Richards, Allen L. 412, 420, 754 Roeffen, Will 1038 Punjabi, Narain H. 76 Ramos, Maria A. 194 Richards, Frank O. 105, 116, 448, Roehrig, John T. 1124, 785 Puplampu, Naiki 20, 270, 767 Ramzy, Reda M. R. 670 453, 640, 818, 1021, 1023, 1024 Roepe, Paul D. 146, 511, 524, 525, Purcell, Lisa A. 520, 890 Randhawa, Jyoti K. 103 Richards, Jack S. 1071, 1076, 318, 530 Purkayastha, Anjan 289 Rangel, Yadira 965 542, 911 Rogayah, Hanifah 185 Pusic, Kae 1068 Ranson, Hilary 1091 Richards, Stephanie L. 233, 390, Rogers, William O. 2 Putnak, Robert 786 Rantala, Anne-Maria 865 391 Rogerson, Stephen J. 303, 510, 910 Putnam, Shannon D. 76 Rao, Grace 1020 Richardson, Jason 1079, 652 Rohousova, Iva 46, 47 Puyol, Laura 1070 Rao, Ramakrishna U. 118 Richie, Thomas L. 549, 568, 570, Rojas, Lazara 702 Pyae Phyo, Aung 523 Rarau, Patricia 307 571, 743, 942, 1009, 1011, 1078, Rojas-Hernández, Saúl 620 Pyo, Kyoung-Ho 623, 626, 632 Rasameesoraj, Maneerat 512, 894 1079 Rollin, Pierre E. 726 Rascon, Alberto 947, 948 Richman, Adam 897 Rollins, Sean 1144, 1145 Q Rasgon, Jason L. 231, 363 Rico-Hesse, Rebeca 357 Romero, Candice 311 Rasmussen, Lynn 610 Riddle, Mark 712 Romero, Mario E. 130 Qadri, Firdausi 1144, 1145, 323, Raso, Giovanna 1029 Riedesel, Melissa A. 1025, 1031 Romero-Montoya, Marcela 604 715, 716 Rathod, Pradipsinh K. 338, 373, 857 Riehle, Michael A. 231, 951, 952 Romoser, Margaret A. 457 Qasimov, Maqsud 1001, 451 Rausch, Kelly 939 Rijal, Suman 747, 830 Romoser, William S. 974 Qian, Feng 939 Ravindran, John 171 Riley, Eleanor 898 Ronan, Jambou 526 Qing-Ge, Sun 806 Rawasia, Wasiq F. 176 Riley, Lee W. 989, 1136 Roncal, Norma E. 873, 883 Qing-Yu, Zhu 806 Rawiwan, Imerbsin 298 Riley, Matthew 902 Root, Jeffrey 644 Quang, Le Hong 1059 Ray, Prabhati 297 Riley, Steven 282 Rosas, Angel 227, 228 Quang, Nguyen Ngoc 152 Rayamajhi, Bishnu B. 994 Rilpuou, Robert 986, 991 Rosen, David 378 Quasie, Olga 77 Rayner, Julian C. 559, 943 Rimi, Nadia Ali 324 Rosenberg, Charles 1152 Quelhas, Diana 1070 Razuri, Hugo R. 1138, 445, 446, 647 Rinaldi, Gabriel 1127, 637 Rosendorf, Linda 1073 Quetz, Josiane S. 75, 80, 81 Read, Andrew 564, 579, 893, 981, Riner, Diana K. 349 Rosenthal, Benjamin M. 12 Quick, Rob 1062 1089 Ringwald, Pascal 894 Rosenthal, Philip J. 366, 895, 537, Quicke, Kendra M. 231 Reeder, John 1022 Rios, Jane 987 853, 854, 1066, 377 Quino, Willi 734 Reese, Necole 880, 881, 883 Rios, Tatiana 130 Ross, Allen 1046 Quiñones, Luz 354, 440 Regis, D. 1078 Riscoe, Mike 295 Ross, Leila Saxby 169, 878 Quintero, Gustavo E. 194 Rego, Reginalo L. 1015 Ritchie, Scott 435 Ross, Ted 263 Quintero-Gil, Carolina 432 Reid, Heidi 190 Rivera, Aidsa 354 Rossi, Cindy 811 Quinto, Llorenc 1070 Reid, Lesley 769 Rivera, Cecilia 990 Roth, Cathy 727 Quispe, Antonio M. 1138 Reiling, Linda 1069, 1071 Rivera, Francheska 272 Rothman, Alan L. 1099, 355 Quispe, Neyda 606 Reimer, Lisa 255 Rivera, Fulton P. 713 Rothstein, Yarrow 298 Quispe Machaca, Víctor R. 484 Reina, Miguel 467 Rivera, Reinaldo 776 Rouamba, Noel 377 Quites, Humberto F. O. 1051 Reis, Dener C. 1051 Rivera-Aguilar, Víctor 620 Rousset, François 362 Quyen, N.T.N 1109 Reis, Mitermayer G. 1136 Riveros, Maribel 713 Roussilhon, Christian 205 Qvarnstrom, Yvonne 313 Reis, Priscilleyne O. 308 Rizaeva, E. V. 404 Rout, Jonathan 1020

245 Author Index The number(s) following author name refers to abstract number.

Rovira, Jose 718 Sampath, Ranga 811 Schlesinger, Jacob J. 1124 Sette, Alessandro 743 Rowe, Christopher G. 939 Sanchez, Felix 267, 268, 474 Schlienger, Raymond 505 Sever, Adrianne E. 804 Rowland, Meghan E. 417, 761 Sanchez, Juan F. 1138, 445, 446 Schloegel, Jesse L. 847 Sevilleja, Jesus E. 84, 630 Rowland, Tobin 757 Sanchez, Luis 922 Schlueter, Jessica 1014 Seydel, Karl B. 143 Rowton, Edgar D. 1016 Sanders, John W. 445, 446, 712, 1138 Schlueter, Shannon 1014 Seyidova, Esmiralda 1001 Roy Chowdhury, Debabani 933 Sandhu, Hardeep S. 443, 804 Schmetz, Christel 824 Shaffer, Donna 1137 Royals, Michael A. 787 Sandison, Taylor 663 Schmidt, Alexander C. 396, 397 Shah, N. Sarita 738 Rubins, Kate 289 Sang, Rosemary 392, 652 Schmidt, Diane 427 Shah, Naman K. 2 Rudiman, Panji I. F. 1104 Sangare, Cheick P. Oumar. 208 Schnabel, David 392, 652, 733 Shaheen, Hind I. 712 Rueda, Ernesto 778 Sangare, Djibril M. 964 Schneider, Dominique 130 Shahinas, Dea 159 Ruel, Theodore 366 Sangare, Laura 189, 371 Schneider, Jessica 522 Shaikh, Taslima 346 Ruesch-Gerdes, Sabine 988 Sangha, Jasbir K. 908 Scholte, Ronaldo G. C. 276 Shakil, Javeria 266 Ruiz, Freddy 722 Sangsuk, Leelaowadee 993 Schotthoefer, Anna 9 Shakya, Krishna P. 118 Ruiz, Jerônimo 274 Sanogo, Dramane 1081, 1083, 1084, Schreiber, Fernanda 467 Shamloul, Moneim 1038 Ruiz, Marilyn 599 113, 332 Schreifer, Albert 831, 832 Shane, Hillary L. 634 Rukelibuga, Joseph 730 Sanon, Antoine 252 Schroeder, Betsy 401, 406 Shanieva, Z. A. 404 Ruprecht, Ruth M. 475 Sanon, Souleymane 932, 934 Schrumpf, Merry E. 11 Shanks, G. Dennis 196 Rush, Amy C. 124 Santalla, Jose A. 130 Schuldt, Linda 490 Shao, John 629 Rusine, John 730 Santana, Francisco S. 1136 Schumacher, Samuel G. 260, 261 Shapiro, Karen 690 Rutta, Acleus M. 548 Santana, Lhissa N. 66 Schwabe, Christopher 221 Shapiro, Theresa A. 151 Rutvisuttinunt, Wiriya 179, 22, 896 Santiago, Helton C. 820 Schwan, Tom G. 11 Sharakhov, Igor 966 Rwakimari, John Bosco 305, 818 Santiago, Jose I. 1064 Schwartz, John 400 Sharakhova, Maria 964, 966 Rwebogora, Faustin 664 Santillan Vadivia, Rosa 942 Schwarz, Margaret 1037 Shargie, Estifanos B. 538 Ryan, Edward T. 323, 610, 715, 716, Santolalla, Meddly 529, 925 Schwarzwalder, Alison 415 Sharif, S. K. 294 1144, 1145 Santra, Sampa 569 Schwenk, Robert J. 1010, 739, 740 Sharma, Paresh 491 Ryder, Robert 224 Sanz, Sergi 1070 Scorza D, Jose V. 828 Sharma, Satish 1038 Ryu, Jae-Sook 624, 625 Saralamba, Sompob 523 Scott, Alan L. 117 Shaw, Alan 1035 Sarfo, Bismark Y. 741 Scott, Erick 309 Shaw, Andrea V. 365 S Sarim, Ses 22, 858 Scott, Marilyn 718 Sheen, Patricia 264 Sariol, Carlos A. 429 Scott, Thomas W. 352, 425, 586, 654, Sheikh, Alaullah 1144, 1145 Sa, Juliana Martha 840 Sarkar, Bhaskar 482 798 Sheikh, Mehraj 60 Sa-Nunes, Anderson 945 Sarkar, Rouha A. 288 Scrimgeour, Angus 544 Shelahi, Fatma 60 Saad, Magdi 649 Sarnoff, Rhonda 104 Se, Youry 22, 858, 896, 907 Shen, Wen-Fan 92 Saavedra-Rodríguez, Karla L. 583, Sarquis, Otilia 1015 Seagraves, Richard 111 Shepard, Donald S. 1093, 399, 442, 1091 Sarr, Ousmane 378 Seake-Kwawu, Atsu 1119 776, 777 Sabchareon, Arunee 436 Sathunuru, Ramadas 881 Sebeza, Jackson 730 Sherman, Jonathan M. 736 Sabeti, Pardis 378, 716 Sathyakumar, Chiminyan 986 Sebikali, C. 487 Shetty, Sharmila S. 735 Sabin, Lora 666, 732, 900 Sattabongkot, Jetsumon 1032, 372, Secor, W. Evan 381, 475, 634 Shi, Lingmei 110 Saborío, Saira 94, 285, 351 562, 944 Seda, Rafael 1096 Shi, Min-Hon 402 Sabot, Oliver 1053, 540 Sauerbrey, Mauricio 1024 Sedegah, Martha 568, 570, 571, 743, Shi, Ya P. 917 Sacarlal, Jahit 160 Sauerwein, Robert W. 1036, 1038 1078 Shi, Zhenli 683 Sacci, John B. 1009 Saul, Allan 1075 Sedyaningsih, Endang 76, 737 Shiao, Shin-Hong 232 Sadowski, Brett W. 874 Saunders, David 1079, 22, 298, 512, Segeja, Method D. 912 Shilengo, Shawn J. 393, 791 Saenz, Fabian E. 515 750, 858, 884, 894, 896, 907 Segura, Jose Luis 221 Shilkin, Keith B. 510 Safi , Najibullah 195 Savage, Amy F. 488 Seim, Anders 114, 330, 1134 Shimada, M. 246 Safi ra, Lisa 1003 Saville, Melanie 437 Sem, Rithy 2 Shimogawara, Reiko 380 Saganda, Wilbrod 365 Saviolakis, George A. 67 Sembuche, S. 548 Shimp, Rich 939 Sagara, Issaka 1075, 1137, 541, 552, Savranskaya, Tatyana 935, 936 Semrau, Katherine 732 Shin, Chang-Sik 300, 517 565, 856 Sawadogo, Simon P. 252, 573 Senba, Masachika 837 Shin, Eun-Hee 623, 626, 632 Sahu, Rajnish 296 Sawanyawisuth, Kanlayanee 409, 764 Senda, James 1068 Shin, Ki Young 632 Saingam, Piyaporn 896 Sawanyawisuth, Kittisak 409, 764 Sener, Kenan 812 Shiva, Murugasampillay 221 Sakamoto, Hirokazu 944 Saye, Renion 541, 552, 566 Seneviratne, Dammika 780 Shoemaker, Charles B. 1128 Sakamuri, Rama Murthy 604 Sayeed, Abdullah A. 135 Seneviratne, Hashini 821 Shomloo, Shawheen 876 Salam, Mohammad A. 1103 Sayo, Renato 571, 743 Senn, Michele 24 Shope, Richard 456 Salas, Carola J. 529, 925 Sazzad, Hossain M. 725, 1000 Senn, Nicolas 24, 307 Shresta, Sujan 793 Salas Clavijo, Alejandra N. 130 Scaraffi a, Patricia 946 Senthong, Vichai 409 Shrestha, Bimmi 95 Salazar, Ferdinand V. 1092, 87 Schabel, David 294 Seok, Ju–Won 273 Shrestha, Binob 994 Salazar, Milagros 685 Schaecher, Kurt 22, 179, 896, 1032 Sepe, Daphne 1022, 255 Shrestha, Bishnu K. 994 Saldarriaga, Omar A. 661 Schaffner, Steve 378 Sepulveda, Jorge 1128 Shrestha, Bhola R. 711 Salib, Mary 307 Schal, Coby 602 Sere, Yves 377 Shrestha, Sanjaya K. 711, 994 Salika, Prasert 615, 993 Schaper, Sabine 728 Seregin, Alexey 685 Shuaib, Faisal 916 Salit, Irving 693 Scheld, Michael 471 Serghides, Lena 367 Shuaibu, Mohammed N. 837 Sallam, Atiya A. 695 Scheld, W. Michael 322 Seriba Doumbia, Salif 1081 Shuck-Lee, Deidra 649 Sallum, Maria Anice Mureb 722, 965 Schellenberg, David 680 Seriwatana, Jitvimal 426 Shukla, Manmohan M. 666, 900 Sallum, M. A. 963 Scherer, Philipp E. 496 Serra-Casas, Elisa 1070 Si, Yuanzheng 161 Sallusto, Federica 422 Schijman, Alejandro G. 38 Sesay, Sanie 509 Siazeele, Kazungu 732 Salotra, Poonam 491 Schilke, Jessica L. 174 Seth, Prameet 367 Siba, Peter 1022 Samake, Sibiry 481 Schimana, Werner 472 Setiawaty, Vivi 737 Sibley, Carol H. 665, 901 Samir, Ahmed 269 Schlarman, Maggie 213 Seto, Edmund Y. 641, 642, 1048 Sidamonidze, Ketevan 754 Sampath, Aruna 168, 297 Schlein, Karen 104 Siddiqui, Asim A. 336

246 Author Index The number(s) following author name refers to abstract number.

Sidhu, Amar Bir S. 536 Small, Jennifer 652, 717 Sow, Samba O. 62, 63 Styer, Linda M. 1095 Sidibe, Bakary 172 Smartt, Chelsea T. 233, 390, 391 Sowe, Maimuna 509 Su, Tianyun 388 Sierra, Gloria 427 Smer, Aiman M. 408, 410 Sowumi, Akintunde 154, 521, 531, Su, Xinzhuan 316, 888 Sijuade, A. 868 Smilkstein, Martin 295, 876 851, 855, 868 Suarez, Jorge L. 584 Sikulu, Maggy 247 Smith, Bryan 22, 858, 896 Spaccapelo, Roberta 1034 Suárez, Luis 647 Sikuyayenga, Mutende 675 Smith, Bryan L. 298 Spadafora, Carmenza 157 Suarez, Victor 995 Silamut, Kamolrat 523 Smith, Davey M. 861 Spalding, Maroya D. 842, 885 Subramanian, Shoba 377 Silengo, Shawn J. 787, 795 Smith, Heidi 1099 Spear, Robert C. 1048, 641, 642 Sudjana, Primal 1104 Siles-Lucas, Mar 1101 Smith, Joseph D. 910 Specht, Sabine 1102 Sugimoto, Kenkichi 838 Siludjai, Duangkamon 615, 993 Smith, Jennifer K. 685 Spindler, Victoria 965 Suh, Yoo-Hun 632 Silué, Kigbafori D. 1029 Smith, Jeanon N. 685 Spring, M. 1078 Sukhbaatar, Munkhzul 30 Silva, Claudia 905, 920 Smith, K. 1078 Spring, Michele 1079 Sukhumavasi, Woraporn 692 Silva, Catherine E. 49 Smith, Vincent L. 578 Sratongno, Panudda 205 Sukupolvi-Petty, Soila 95 Silva, Guida 308 Snider, Cynthia 315 Srichairatanakool, S. 209 Sulca, Juan 998 Silva, Leandro 989 Snounou, Georges 26 Srichairatanakul, Utaiwan 1032 Sullivan, Frank 505 Silva, Sheyla 423 Snow, Robert W. 192, 1028, 71 Sridaran, Sankar 176, 3 Sultana, Rebeca 288, 324 Silver, Karlee L. 139, 1044 Soares, Alberto M. 1140 Srijan, Apichai 711 Sultana, Shazia 102 Sim, Benedict 477 Soares, Irene S. 200 Sripa, Banchob 1130 Sumari, Deborah 4 Sim, Cheolho 236 Soares Magalhaes, Ricardo 106 Srivastava, Anuradha 836 Sumba, Peter 918 Sim, Derek 893 Soberon, Valeria 23, 529, 925 Sriwichai, Sabaithip 22, 858, 896 Sumibcay, Laarni 686 Sim, Kim Lee 206, 897 Sobral, Mariana C. M. 781 Ssekabira, Umaru B. 305 Sun, Jiaren 350 Sim, Shuzhen 792 Sobsey, Mark D. 1063 Ssekitoleko, Richard 322 Sun, Wellington 354 Sima, Victor 221 Socheat, Duong 22, 523, 858, 896, St. Pierre, Tim G. 186, 862 Sundar, Shyam 747, 830 Simard, Frederic 573, 575, 720, 907 Staedke, Sarah 189, 1066 Sunderland, Deirdre 691 957, 966 Sodahlon, Yao 112, 1134, 114, 115, Staley, Molly 1122 Sundrakes, Siratchana 896 Simbauni, Jemimah A. 249 329, 821 Standish, Katherine 423, 94, 96 Sungpradit, Sivapong 117 Simington, Sherricka 1142 Sodeinde, Olugbemiro 70 Stanisic, Danielle I. 910, 911 Sungvornyothin, Sungsit 17 Simmons, Leah E. 591 Sodha, Samir 1142, 1143 Stark, Lillian M. 1002, 969 Supali, Taniawati 709 Simoes, Mariana C. 281 Sodiomon, Sirima B. 572, 899, 903, Stauber, Christine E. 1063 Supek, Frantisek 507 Simons, Adam P. D. 39 915, 929 Stearns, Susan 107 Surachetpong, Win 1110 Simpson, Julie A. 542 Soebiyanto, Radina 195, 265 Stedman, Timothy 838 Suri, Amreena 316 Simpson, Jennifer E. 389, 591 Sogoba, Nafomon 11, 598, 972 Steel, Argon 88 Surin, Johari 477, 617, 695 Simwaka, Bertha N. 765 Sohner, Kevin 56 Steers, Nick 739 Susanti, Augustina I. 2 Sing, Neeru 904 Soisson, Lorraine 743, 1074, 1078 Steger, Kirby 41 Susapa, Melinda 1022 Singer, Burton H. 1029 Soliman, Atef 649 Stein, Aryeh D. 102 Susilarini, Ni Ketut 737 Singh, Kavita 344 Solomon, Wesley 916 Steinauer, Michelle L. 1049 Sutherland, Colin 175, 680 Singh, Mrigendra P. 666, 900 Soloski, Mark 415 Steinbeiss, V. 1078 Sutherland, Laura J. 45 Singh, Neeloo 133 Soma, Viju 910 Steiner, Kevin 368 Suttiprapa, Sutas 1130, 637 Singh, Neeru 666, 900 Somsak, Voravuth 209 Steketee, Richard 917 Sutton, Patrick L. 905 Singhal, Arvind 457 Song, Guanhong 562 Stenger, David 455 Suwannachote, Nanatawan 982 Singleton, Michael R. 52 Song, Hyun-Ouk 624 Stephens, Henry A. 355 Suwonkerd, Wannapa 17, 982 Sinha, Arvind 57 Song, Jin-Won 686 Stergachis, Andreas 189 Svennerholm, Ann-Mari 713, 715 Sinkala, Moses 505 Song, Shao-Xia 731 Steurer, Francis 134 Swaby, James A. 44 Sinnis, Photini 1006, 520 Sonye, George O. 51, 246 Stevenson, Abbie 997 Swai, Ndealilia 629 Sinou, Véronique 1059, 7 Soodoo, Natasha K. 997 Stevenson, Mary M. 877 Sweat, Mark 42 Siregar, Alyya S. 1003 Soomro, Shahid 988 Stewart, Ann 928 Swier, Vicki J. 809 Sirima, Sodiomon B. 932, 934 Soong, Lynn 350, 662 Stewart, Barclay T. 371 Swierczewski, Brett E. 284 Siripongpreeda, Natawan 603 Sorber, Katherine 892 Stewart, V. Ann 544 Sylla, Mamadou B. 62, 63 Sirivichayakul, Chukiat 436 Sosa, Melinda 610, 813 Stiles, Jonathan K. 497, 741, 916 Syphard, Luke 3 Sirot, Laura 1018 Sosa-Estani, Sergio 834 Stinchcomb, Dan T. 393, 787, 791, Szarek, Walter A. 514, 516 Sisowath, Christin 178 Soto, Edison 228 795, 992 Sztein, Marcelo B. 744 Sissoko, Ibrahim M 481 Soto, Giselle 736 Stirling, Verity 510 Sissoko, Mady 1074 Soto, Victor 1122 Stocker, J. T. 1086 T Sissoko, Mahamadou 541, 552 Soto-Calle, Veronica E. 187 Stockmyer, Justin B. 170 Sissoko, Sibiri 27 Soto-Cornejo, Katherine 376 Stoddard, Steven T. 352, 586, 654, Tabachnick, Walter J. 391 Sissoko, Seydou 62, 63 Souaibou, Mouhamadou 1023 798 Tac-an, IIya A. 1005 Sithy, Ngo 907 Soucko, Constance 481 Stolk, Wilma A. 328 Tachibana, Mayumi 372, 562, 944 Siwo, Geoffrey H. 341 Soulama, Issiaka 932, 934 Stoney, Jillian 508 Tack, Danielle M. 784 Skarbinski, Jacek 664 Souleymane, Sanon 572, 899, 915, Stoops, Craig A. 420 Taft, Andrew S. 697 Skelly, Patrick J. 1128, 1129, 1132 929 Stoppie, Paul 988 Tagoe, Janice 270, 767 Skerlj, Renato 166 Souleymanou, Yaya 1023 Storms, Aaron 770 Tainchum, Krajana 17 Skewes-Cox, Peter 285 Soumaoro, Lamine 1081, 1083, Stoute, Jose A. 157, 201, 202 Takagi, Akihide T. 206, 1008, 1011 Skinner-Adams, Tina 158, 299 1084, 113, 332 Streatfi eld, Peter K. 1000 Takahashi, Ken 409 Skora, Joseph F. 111 Soumare, Massitan D. 710 Streatfi eld, Stephen 1038 Takala, Shannon 1074, 566 Skovmand, Ole 984 Sousa, Jason C. 873, 880, 881, 882, Streit, Thomas G. 708 Takemae, Hitoshi 924 Slatko, Barton E. 674, 1112 883 Strickman, Daniel 386, 757 Takeo, Satoru 562, 944 Sligar, Jessica 132, 748, 829 Sousa Silva, Marta 490 Strode, Clare 1091 Takhampunya1, Ratree 786 Slike, Bonnie M. 430 Souza, Verena M. M. 321 Stroup, Suzanne E. 629 Takol Chareonsirisuthigul, Takol Slutsker, Laurence 1027, 917 Souza-Neto, Jayme A. 240, 792 Strouse, John J. 775 782 Sluzas, Emily M. 431 Sovero, Merly 267, 268, 987 Sturrock, Hugh J. W. 458 Taleo, George 190

247 Author Index The number(s) following author name refers to abstract number.

Talhari, Sinésio 832 Thévenon, Audrey D. 846 Traore, Mariam 856 Unnasch, Thomas R. 1002, 121, 673, Talisuna, Ambrose O. 25 Thibodeaux, Brett A. 1124 Traore, Mohamed M. 1116, 961 675, 969 Talkington, Deborah 1142 Thiemann, Tara C. 387 Traore, Oumar B. 208 Urbanski, Jennifer 15 Tall, Koureissi 481 Thomas, Andrew P. 170 Traore, Pierre 481 Urgaonkar, Sameer 878 Tally, John 750 Thomas, Matthew 579, 981, 1089 Traore, Rokia 665 Urquhart, AnneMarie 1009 Talvani, A. 746 Thomas, Nicole M. 941 Traore, Sekou F. 1083, 1084, 113, Ursic Bedoya, Raul 229 Tam, Clarence 780 Thomas, Stephen 786 332, 598, 961, 964 Ursing, Johan 183, 177 Tam, Mifong 877 Thomas, Tania A. 738 Traore, Zoumana I. 208 Usmani-Brown, Sahar 724 Tamminga, Cindy 1078, 1079 Thompson, Andrew 751 Travassos da Rosa, Amelia P. A. 684, Uthaipibull, Chairat 173, 209, 216, Tan, Asako 341 Thompson, Elloise 150 689 521 Tang, Kevin 414, 616 Thompson, Joanne 374 Travers, Thomas 152 Utzinger, Jürg 633, 1029 Tang, Xianchun 263, 683 Thompson, Jennifer K. 911 Travi, Bruno L. 661, 749 Tangpukdee, Noppadon 1045 Thompson, Travis A. 681 Travinsky, Bridgit 9 V Tangteung, Anchalee 873 Thompson, Winston 497 Trejo Maguina, Nilda Victoria 736 Tangthongchaiwiriya, Kuntida 894 Thongkukiatkul, Amporn 372 Tremblay, Jacque 1128 Valderrama, Yadira 647 Taniuchi, Mami 631 Thonnard, Joelle 1074 Trifonova, Iva 648 Valderramos, Juan-Carlos 890, 891 Tanner, Marcel 1029 Thuma, Philip 543 Triglia, Tony 1071 Valderramos, Stephanie G. 890 Tanowitz, Herbert B. 496, 770 Thumar, Bhavin 396, 397 Trilar, Tomi 286 Valencia, Cristian R. 479 Tanyuksel, Mehmet 53, 628 Thwing, Julie I. 1054 Trimnell, Adama 1011 Valencia, Eddy 606 Tapia, Laura L. 554 Tiamkao, Somsak 409 Trimpe, Lori 1064 Valencia, Teresa 734 Tapia, Milagritos 62, 63 Tibenderana, James K. 71 Tripet, Frederic 21 Valenzuela, Jesus L 481 Tappero, Jordan 663 Ticona, Eduardo 264 Tripura, Rupam 523 Valera, Luis 228 Taracena, Mabel 760 Tidwell, Richard R. 129, 752 Tronchet, Carole 1061 Valiente, Betty 260 Taramelli, Donatella 150 Tierney, Eveline 1076 Trottman, Paul A. 681, 865 Valks, Andrea 97 Tareen, Shama Ruqiya 103 Tigabu, Bersabeh 808 Troyo, Adriana 433 Vallejo, Efrain 653 Tarleton, Rick L. 500 Timbine, Antimbe 149 Tsai, Hung-Chin 402 Vallely, Andrew 190 Tasseva, E. 648 Timinao, Lincoln 375 Tsai, Kun-Hsien 421 van de Vegte-Bolmer, Marga 1036 Tatarsky, Allison 540 Timmermans, Ans 22, 907 Tsai, Wen-Yang 29 Van Dyke, Melissa K. 1047 Tavul, Livingstone 1071 Tinker, Tim 690 Tsang, Mazie 1068 van Eijk, Anne M. 917 Tawiah, Naa Adjeley 277 Tiono, Alfred 932, 934 Tsang, Victor C. W. 59, 310 van Gemert, Geert-Jan 1036 Tax, Dennis 1033, 569 Tirakarn, Srisuda 214 Tsao, Kimberly 10 van Hensbroek, Michaël B. 667 Tay, Sammy C. K. 211, 77 Tisch, Daniel J. 1022 Tse, Sze-Wah 1006 van Herpen, Teun 513 Taylor, Charles E. 1116 Tissera, Hasitha 780 Tsertsvadze, Nicolas 754 Van Panhuis, Wilbert 32 Taylor, Diane Wallace 139, 846 Tjaden, Jeffery 648, 649 Tsetsarkin, Konstantin A. 646, 976 Van Schaijk, Ben C. L. 1036 Taylor, Diane W. 563 Toe, Kobié Hyacinthe 252, 573 Tshala-Katumbay, Desire D. 485 Van Tyne, Daria 378 Taylor, Jennifer 507 Tokumasu, Fuyuki 840, 844 Tshefu, Antoinette 1026, 224, 681 Van Voorhis, Wesley C. 170 Taylor, Mark J. 333, 817 Tolba, Mohammed 144 Tshiswaka Kashalala, Gauthier 226 Van Zee, Janice 1014 Taylor, Steve M. 1026, 681, 865 Tolouei Semnani, Roshanak 1081 Tsorin, Boris 56 Vanden Eng, Jodi 589 Taylor, Terrie E. 1041, 143, 667 Tomás, Ana M. 490 Tsuboi, Takafumi 1009, 372, 562, 944 Vanlandingham, Dana 684 Teddy, Kaberuka 609 Tomasello, Danielle 893 Tucker, Compton J. 652 Vanloubbeeck, Yannick 1032 Teekam, Paul 863 Tomashek, Kay 354, 439, 440, 776, Tucker, Matthew S. 892 VanWormer, Elizabeth 690 Teem, John 313 789 Tukesiga, Ephraim 818 VanZee, Janice P. 49 Teixeira, Clarissa 481 Tomayao, Agnes D. 1005 Tullo, Gregory 1067, 1075, 344 Vardo-Zalik, Anne M. 1, 220 Teja-Isavadharm, Paktiya 22, 298, Tominsky, Daniella 211 Tully, Charla C. 613 Vargas, Daniel 228 512, 894, 896 Tongjai, Siripong 629 Turell, Michael J. 386, 392, 757, 811 Vargas, Jorge 653, 998 Tekete, Mamadou 149, 208 Torii, Motomi 372, 562, 944 Turk, John 125 Vargas, Victor 311 Tekwani, Babu 168, 296 Toronjadze, Tamar 986, 991 Turner, Gareth D. H. 137 Vargas-Inchaustegui, Diego A. 350 Telford, III, Sam R. 12, 13 Torrero, Marina N. 1080, 1082, 1086 Turyakira, Eleanor 26 Varma, Sudhir 944 Tellez, Yolanda 351, 94 Torres, Fernando 604 Twohig, Erin 732 Vasanthapuram, V. Ravi 443, 804 Telly, Antandou 710 Torres, Katherine 376, 558 Twum, Amoani 314 Vasilakis, Nikos 683 Telly, Nouhoun 62 Torres, Vladimir 157 Tyndall, Erin 536 Vasquez, Jessica 768, 79 Tenaw, Eskindir 538 Torres-Perez, Fernando 416 Tyner, Stuart 22, 179, 858, 896 Vasquez, Lucy 606 Tenorio, Antonio 427 Tosh, Donna 1079, 550 Vasquez, Laura C. 584, 828 ter Haak, Mariska 1033 Touma, Maki 838 U Vasquez, Libia R. 828 ter Kuile, Feiko 917 Toure, Mahamadou B. 1116 Vasquez-Belchoir, Jorge 798 Terashima, Angelica 271 Toure, Offi anan A. 665, 901 Ubol, Sukathida 782 Vasquez-Prokopec, Gonzalo 352 Terlouw, Dianne J. 834 Toure, Ousmane B. 856 Uddin, Main 324 Vaughan, Jefferson A. 256 Terrientes, Zilka I. 563 Toure, Sekou 172 Uddin, Musleh 324 Vaughn, David W. 355 Tesh, Robert B. 684, 689, 976 Toure, Seydou 704 Udhayakumar, Venkatachalam 176, Vazquez-Prokopec, Gonzalo M. 254, Tetteh, John 913, 914 Toure, Sidy 856 2, 23, 3, 529, 666, 900, 925 435, 589, 798 Tetuanui, Albert 1019 Tovar, Marco 734, 736 Ugulava, Natalia 1038 Vegas Olaya, Walter 942 Teururai, Sylviane 1019 Townsend, Jeffrey P. 447 Uhart, Marcela 292 Veis, Arthur 379 Teuscher, Franka 534 Tozan, Yesim 1057 Umaña, Claudia 760 Vejbaesya, Sasijit 355 Thacher, Tom D. 304 Traina, Mahmoud I. 408, 410 Umareddy, Indira 333 Veland, Nicolas 492 Thai, C.Q. 1109 Tran, Thanh 158 Umaru, John 105, 116, 444 Velasco, John Mark S. 1005 Thanh, Nguyen Xuan 152 Traore, Abdel K. 113 Umemoto, Saori 551 Velez, Ivan D. 1008, 206 Thea, Donald M. 732 Traore, Boubacar 1007 Unal, Melih H. 628 Vely, Jean-Francois 708 Thera, Mahamadou A. 1042, 1074, Traore, Bourama 481 Unger, Alon 1136, 831 Venancio, Thiago M. 319 566 Traore, Drissa 1074 Unger, Maria 964 Vephkhvadze, Nino 754 Theron, André 280 Traore, Karim 845, 1039, 1074 Unicomb, Leanne 1061 Vera, Delphis 111

248 Author Index The number(s) following author name refers to abstract number.

Verani, Jennifer R. 634, 1134 Wang, Lin-fa 683 White, Gregory S. 1002, 969 Woodson, Sara E. 1123 Verastegui, Manuela 484, 658 Wang, Mei-Hui 361 White, John 857 Wright, Linda 224 Verjovski-Almeida, Sérgio 319, 643 Wang, Michael Z. 752 White, Karen 751 Wring, Stephen 132, 748, 829 Verma, Saguna 1098 Wang, Ruobing 1008, 1011, 206 White, Lisa J. 523 Wu, Bo 1112, 674 Vernet, Guy 1042 Wang, Shuo 641 White, Michael T. 567 Wu, Haiwei 379 Vesely, Brian A. 42, 836 Wang, ShanQing 860 White, Nicholas J. 135, 137, 155, Wu, Han-Chung 92 Viana, Giselle M. R. 528 Wang, Wei-Kung 29 523 Wu, Yineng 1012 Vianney, Nizeyimana 609 Wang, Weimin 867 Whitehead, Stephen S. 396, 397 Wu, Yimin 1038, 562 Vicuña-Fernandez, Nelson 828 Wang, Xiaoxia 639 Whitehouse, Chris A. 811 Wunderlich, Gerhard 193 Vieira, Pedro Paulo 335 Wang, Xian-Jun 731 Whittaker, Danielle 741 Wylie, Blair J. 666, 900 Vigliano, Carlos A. 500 Wang, Xihong 881 Whittington, Jessica 936 Wynn, Willard W. 578 Vigliano, Carlos V. 38 Wang, Yu 170 Wibowo, Heri 709 Wysocki, Vicki 946 Vignuzzi, Marco 688 Wang, Ying 218 Wichmann, Ole 399, 436 Vilcarromero, Stalin 647, 654, 995 Wang, Yue 867 Wichterman, Jennifer 888 X Villar, Juan C. 778 Wang, Zhi-Qiang 731 Widjaja, Susana 420 Villar, Luis A. 778 Wang, Zhinning 892 Wiegand, Roger 378, 536 Xi, Zhiyong 364 Villarreal, Juana 827 Wanga, Joyce 1009 Wieler, Lothar H. 72 Xianli, Jia 336 Villasis, Elizabeth 558, 923 Wanionek, Kimberli A. 396, 397 Wiesen, Jonathan 770 Xiao, Lihua 658 Villegas, Leopoldo 3 Wanzira, Humphrey 537, 663 Wilfred, Mbacham 560 Xiao, Shu-Yuan 684 Villinger, Francois 441, 90 Ward, Brian J. 782 Wilkerson, Richard C. 718, 722, Xiaoping, Kang X. P. 806 Vinayak, Sumiti 2, 3 Ward, Lorrayne 1053 963, 965, 968 Xie, Changan 146 Vinetz, Joseph M. 317, 861, 1115, Ware, Lisa 1032, 1079, 570 Wilkins, Patricia P. 310, 59 Xie, Lisa 161, 162, 163, 164, 750, 1146 Warhurst, David C. 175 Williams, F. 1078 873, 880, 881, 882 Vingas, Kleo 847 Warimwe, George 1069 Williams, Greg A. 388 Xie, Yan 364 Viotti, Rodolfo J. 500 Warren, Chris 156 Williams, Gail M. 1046 Xin, Lijun 350 Virtanen, Mailis 504, 505 Warren, Cirle A. 84, 630 Williams, Jack 1079 Xiong, Xu 145 Vissa, Varalakshmi 604 Warren, Jessica 97 Williams, Jeffrey F. 1064 Xu, Peng 262 Vivas, Livia 150 Wartel-Tram, Anh 436 Williams, Katherine L. 356, 422, 428 Xu, Yao 364 Vlahakis, Jason Z. 516 Wasley, Annemarie 645 Williams, Maya 1104, 420 Xu, You-Fu 731 Vlkova, Michaela 47 Wasserberg, Gideon 1016 Williams, Steven A. 670 Xuan Thanh, Nguyen 1059 Volf, Petr 46, 47 Waters, Andrew P. 215 Williamson, John 1020, 1027, 917 Volfova, Vera 47 Waters, Norman C. 885 Williamson, Kathryn 1040 Y Volk, Sara 689 Watkins de Jong, Laurel 951 Williamson, Kim C. 316, 879 Volkman, Sarah 378 Watts, Douglas M. 1004 Willis, Derek W. 1058 Yabsley, Michael 761 Volnay, Béatrice 335 Waweru, Jayne 1055 Wilson, Donald 409 Yadava, Anjali 1032, 1079, 570 Volper, Esther M. 91 Way, Ann A. 1026 Wilson, Michael Yakob, Laith 594 von Geldern, Thomas W. 751 Weaver, Marcia R. 305 Wilson, Michael D. 20, 182, 245, Yalaoui, Samir 1036 von Kruger, Vanda M. A. 495 Weaver, Scott C. 689, 1004 270, 314, 539, 767, 819 Yalwala, Santos 392 Vora, Neil 366, 663 Webb, James P. 388 Wilson, Mary E. 39, 493, 650, 660, Yamada, Jun 551 Voronov, Dmitry A. 954 Webb, Thomas R. 1131, 320 997 Yamaguchi, Yoko 551 Vos, Martijn 1036 Webster, Joanne P. 704, 1052 Wilson, Mark L. 1047, 1117 Yamazaki, Akiko 837 Vounatsou, Penelope 1029 Weil, Ana A. 323 Wilson, Nana O. 741, 916 Yan, Guiyun 1, 220, 258, 361, 594, Vulule, John M. 140, 142, 199, 203, Weil, Gary J. 118, 119, 124, 670, Wingi, Brenda 307 679 555, 557, 906, 918, 984, 1025, 1141 674, 814 Winikor, Jared 237 Yanagi, Tetsuo 126, 837 Vuolo, Elena 815 Weill, Mylène 1090 Winoto, Imelda L. 420 Yanagihara, Richard 686 Vythilingam, Indra 1113 Weina, Peter J. 67, 161, 162, 163, Winpisinger, Kim 56 Yang, Baojun 950 164, 297, 750 Winter, Rolf 295 Yang, Chao-Fu 234 W Weinberg, Michelle 645 Winzeler, Elizabeth A. 5 Yang, Guangxiao 1012 Weinkopff, Tiffany S. 331, 659 Wipf, Peter 873 Yang, Hong 731 Wacker, Mark A. 341 Weiss, Greta E. 1007 Wiredu, Edwin 913 Yang, Kun 707 Wahala, Wahala M.P.B. 31, 422, Weiss, Louis M. 496 Wirth, Dyann 169, 378, 531, 536, Yang, Li 110 779, 780, 790 Weiss, Manfred S. 490 878 Yang, Yi-Ching 411 Waisberg, Michael 1007 Weiss, Noel 189 Wise de Valdez, Megan R. 358 Yang, Yu R. 55 Waitumbi, John 426, 544, 902 Welburn, Sue 839 Wismarini, Desak 185 Yanni, Emad 650, 997 Waldman, Sarah 537 Wele, Mamadou 535 Witzig, Richard S. 554 Yapar, Mehmet 812 Walker, Edward 361, 593, 599 Wellems, Thomas 840, 888 Woelfl , Gabriele 1126 Yarina, Tamasin R. 754 Walker, Larry A. 155, 168, 296 Welter, Kathryn 105, 444 Wojcik, Richard A. 111, 1005 Yarlett, Nigel 132, 748, 829 Walker, Todd W. 578 Welty, Suzanne 104 Wolf, Christian 524 Yaro, Alpha S. 588 Wallace, Carrie 610 Wen, Tzai-Hung 802 Wolf, Roman F. 783 Yaro, Jean B. 932 Wallqvist, Anders 902 Were, Tom 141, 142, 553, 555, 556, Wolfe, Roger J. 16 Yaro, Jean Baptiste 934 Walsh, Douglas 426 557, 742 Wolfner, Mariana F. 1018 Yasnot, Maria F. 194, 65 Walson, Judd L. 369, 371 Wertheim, Heiman F. L. 98 Wolkon, Adam 538 Yasunami, Michio 837 Walter, Verena 504, 505, 853, 854 Wesche, David 224 Wolofsky, Kayla T. 343 Yatich, Nelly 916 Walters, Adam R. 1063 Wesson, Dawn M. 54, 238, 585, Won, Kimberly Y. 312, 814 Yeaman, Michael 494 Walton, Shelley 8 601, 602, 977 Wong, Jacklyn 586 Yeboah-Antwi, Kojo 666, 732, 900 Wamachi, Alex 745 Westbrook, Catherine J. 243 Wongsrichanalai, Chansuda 2 Yeka, Adoke 305 Wamala, Joseph F. 726 Westerman, Richard 298 Woo, Lauren 314 Yeom, Joon-Sup 181 Wan, K. L. 617 White, E. Lucile 610, 813 Woodall, John P. 98 Yik, Fong M. 1113 Wanderley, Joao L. M. 662 White, Frankie H. 414, 616 Woodard, Lauren E. 151 Yildiz, Senol 53 Wang, Jingwen 1012 White, Gary L. 783 Woods, Christopher W. 775 Yin, Lai 507 Yingst, Samuel 649

249 Author Index The number(s) following author name refers to abstract number.

Yingyern, Kritsanai 179, 896 Zhao, Weiguo 661 Yinhui, Yang Y. H. 806 Zheng, Qiang 750 Ylostalo, Joni H. 1043 Zhong, Bo 1048, 642 Yoda, Bernadette B. 704 Zhong, Daibin 1 Yogiara, Yogiara 76 Zhong, Kathleen 1044, 139 Yohn, Christopher 918 Zhong, Yang 683 Yongqiang, Jiang Y. Q. 806 Zhou, Guofa 258 Yongvanitchit, Kosol 1032 Zhou, Hong 1067, 1075, 344, 565 Yoo, Won Gi 273 Zhou, Huayun 867 York, Steve 56 Zhou, Yang 779 Yoshino, Timothy P. 635, 697 Zhu, Daming 561 Yougoude, Abudoulaye 1023 Zhu, Jinsong 953 Younan, Rasha 648 Ziegler, Rolf 951 Young, Ginger 1096 Ziegler, Sarah A. 684 Yount, Boyd 790 Zielinski-Gutierrez, Emily 457 Youssouf, Kabore 572 Zimic, Mirko 736 Yozwiak, Nathan 285 Zimmerman, Peter A. 1047, 186, 255, Yu, Jianmei 714 336, 375, 45 Yu, Jae Ran 926 Zink, Rebecca 123 Yu, Mei-Ching 411 Zitzmann, Nicole 428 Yu, Poravuth 523 Zollner, Gabriela 1016 Yuan, Jing 888 Zompi, Simona 356 Yuan, Lewis 290 Zongo, Issaka 377 Yuan, Wen 471 Zuber, Patrick L. F. 735 Yuda, Masao 215, 927 Zumaquero-Rios, Jose Lino 702 Yuentrakul, Prayoon 165 Zurovac, Dejan 71 Yun, Nadezhda E. 685 Zwane, Alix 1060 Yunianto, Andre 420 Yunus, Emran B. 135 Yurttas, Yuksel 53 Yusibov, Vidadi 1038, 41 Yuthavong, Yongyuth 173, q09, 214, 216

Z

Zacks, Michele A. 685 Zaidi, Anita K. M. 102 Zaki, Sharif 1142 Zambrano, Betzana 442 Zambrano, Maria L. 414 Zamora, Elvira 227 Zamora Perea, Elvira 576 Zanini, Graziela M. 843 Zanis, Michael J. 959 Zaramba, Sam 818 Zarowiecki, Magdalena 721 Zavala, Fidel 1006 Zavaleta, Carol 1138, 445, 446 Zea Flores, Guillermo 1024 Zemtsova, Galina E. 413 Zeng, Qiang 873 Zerlotini, Adhemar 274 Zevallos, Karine 260, 261 Zhang, Chunlin 786 Zhang, Huarong 407 Zhang, Jian 218 Zhang, Jing 161, 162, 163, 164, 750, 873, 880, 881, 882 Zhang, Jian Z. 55 Zhang, Liang 881 Zhang, Peng 297 Zhang, Qiong 480 Zhang, Shukeng 110 Zhang, Shuyi 683 Zhang, Wen-Yi 731 Zhang, Xu 673 Zhang, Xing 953 Zhang, Yong-Kang 816 Zhang, Zhiwen 14, 608

250 Speaker and Session Chair Index for Plenary, Symposium, Meet the Professors and Mid-Day Sessions The number(s) following individual’s name refers to session number.

A Bompart, Francois 85 Cuevas, Luis 111 Gause, William 107 Bosch, Irene 109 Cunningham, Jane 111 Gaydos, Charlotte 43 Abboud, Labeeb 81A Bosio, Catharine 178 Czerkinsky, Cecil 21 Geary, Tim 103 Achee, Nicole 51, 152 Boslego, John 52A Gelband, Hellen 165 Adams, Emily 3 Boulware, David 27 D Gershman, Mark 59 Adams, John 160 Bourgeois, Lou 21 Gething, Peter 108 Adegbola, Richard 180 Bourne, Peter 134 Dandu, Madhavi 126 Ghani, Azra 15 Adeyi, Olusoji 165 Bowden, Robert 98 Das, Ashis 160 Gibbs, E. 151 Admasu, Kesetebirhan 137 Bowman, Dwight 153 Day, Nicholas 17, 64 Gibbs, Samantha 151 Agosti, Jan 21, 41A Brandling-Bennet, David 13, 137 de Sousa, Alexandra 142 Gillespie, Joseph 12 Agre, Peter 1 Branston, Ruth 28 DeCock, Kevin 71 Gilman, Robert 44, 163 Aguirre, Alonso 151 Brantus, Pierre 155 Denery, Judith 124 Glass, Roger 160A Ahmed, Qanta 117 Brault, Aaron 7 Denkers, Eric 178 Gleeson, Todd 4 Akkihal, Anup 109 Breiman, Robert 40A, 56, 160A, 172 d’Harcourt, Emmanuel 142 Godfrey-Faussett, Peter 58 Aksoy, Serap 23, 133A Brewer, Thomas 52A Dickerson, Tobin 124 Gomes, Melba 57 Alcantar, Norma 102 Brooks, W. Abdullah 40A, 180 Dimopoulos, George 90, 101 Gottlieb, Michael 52A, 168 Ali, Doreen 30 Brown, Clive 174 Dinglasan, Rhoel 29, 90 Gower, Emily 32 Allan, Richard 128 Bruce, Nigel 180 Dondorp, Arjen 164 Green, Sharone 156 Allen, Judi 107 Brunette, Gary 95 Donnelly, Martin 127, 157, 181 Greenwood, Brian 28, 53 Alonso, Pedro 53 Bryce, Jennifer 142 Doolan, Denise 94 Grieco, John 40, 51 Anderson, Alicia 4 Burgess, Timothy 33 Dorkenoo, Ameyo 155 Guerin, Philippe 45 Andre, Richard 40, 51 Dorsey, Grant 45 Guerra, Carlos 108 Andrus, Jon 13 C Dougan, Gordon 56 Guerrant, Richard 70, 168 Arguin, Paul 95 Drebot, Michael 7 Guilhem, Dirce 166 Aronson, Naomi 33 Caffrey, Conor 103 Dreibelbis, Robert 173 Gurtler, Ricardo 75 Asiimwe, Caroline 111 Calisher, Charles 96 Duffy, Patrick 106 Attardo, Geoffrey 23 Cama, Vitaliano 153 H Aultman, Kathryn 122 Campbell, Karen 143 E Aung, Phyo 160 Campbell, Carlos (Kent) 13, 53, 137 Haggerty, Patricia 11 Austin, Christopher 103 Campbell, Karen 143 Earl, Christopher 141 Haldar, Kasturi 86 Azziz-Baumgartner, Eduardo 172 Cardemil, Cristina 142 Earle, Duncan 137 Hale, De Von 48 Cardosa, Jane 171 Ebel, Gregory 26, 80 Hall, James 14 B Carlin, Ellen 153 Eckhoff, Phillip 15 Hamel, Mary 71 Carucci, Daniel 109 Edelson, Paul 174 Hamer, Davidson 27, 70A, 81, 130, Baggett, Kip 35 Carvalho, Edgar 119 Einterz, Robert 48 135 Baiden, Rita 57 Casares, Sofi a 41 Eisen, Rebecca 31 Hanes, Lee 23 Bailey, Robin 32 Cassell, Gail 141 Eisen, Lars 129 Hanley, Kathryn 171 Baker, David 19 Castellanos, Martin 174 Eisinger, Robert 11 Hanson, Christy 97 Balaban, Victor 117 Caulfi eld, Laura 168 Ellis, Michael 4 Harris, Eva 68 Barillas-Mury, Carolina 101 Chang, Michelle 30 Emad, Yanni 70A Hatz, Christoph 163 Barnes, Karen 45 Chen, Lin 163 Endy, Timothy 156 Hay, Simon 108, 122 Barnett, Elizabeth 70A Cheng, Qin 158 Engels, Dirk 87 Hayden, Frederick 163 Barnwell, John 158 Chew, Michael 28 Epstein, Jay 186 Hayden, Mary 31 Barrett, Michael 14 Chimumbwa, John 118 Escobedo, Miguel 174 Haynes, John 136 Barron, Eric 31 Chin, Richard 52A Estes, Sue 136 Hemingway, Janet 157 Barry, Michele 2, 67 Chin, James 13 Evans, Carlton 68 Hernandez, Milton 22 Bausch, Daniel 68, 177 Chiodini, Peter 158 Herwaldt, Barbara 25, 78, 186 Beadell, Jon 23 Chitnis, Nakul 15 F Heymann, David 52 Beaty, Barry 129 Chitsulo, Lester 103 Heysell, Scott 55 Beerbohm, Elissa 118 Chizema, Elizabeth 137 Fairhurst, Rick 8, 127 Higgs, Stephen 11, 22 Feikin, Daniel 71 Beeson, James 82 Christophides, George 101 Hightower, Allen 71 Fenwick, Alan 76 Beetham, Jeffrey 88 Clemens, John 21, 52A Hill, Nigel 51 Fields, Barry 35 Bell, David 111, 158 Clements, Archie 42 Hill, Catherine 12 Fleischauer, Aaron 117 Bergquist, Robert 42 Coghlan, Renia 100 Hjelle, Brian 46 Fleming, Fiona 76 Berman, Josh 161 Cohen, Adam 180 Hoffman, Steve 94 Floyd, Katherine 58 Bern, Caryn 63 Coldren, Rodney 33 Holmes, Eddie 171 Fortes, Filomeno 30 Bernier, Ulirich 40 Coleman, Michael 157 Hotez, Peter 52, 76, 86, 123 Fox, LeAnne 155 Besansky, Nora 181 Coles, Christian 43 Houpt, Eric 168 Freedman, David 83 Bethony, Jeff 123 Colley, Daniel 87 Hynes, Noreen 148 Fried, Michal 44 Beverley, Stephen 88 Collins, Frank 29, 53 Friedman, Jennifer 86 Bhatia, Ajay 3 Conn, Jan 152 I Binka, Fred 85, 105 Connor, Stephen 31, 136 Birkett, Ashley 29, 94 Conrad, Patricia 151 G Iverson, Erik 81A Black, Bill 157 Izurieta, Ricardo 102 Conway, David 127 Gamboa, Dionicia 158 Blanton, Ronald 87 Cookson, Susan 130 Garba, Amadou 76 Boele van Hensbroek, Michael 86 J Coosemans, Marc 122 Garcia, Hector 27, 119 Bokma, Bob 151 Cortes, Alfred 41 Gardiner, Donald 19 Jacobs-Lorena, Marcelo 90 Bolling, Bethany 7 Costero, Adriana 11, 22, 61 Gatton, Michelle 158 Jacobson, Julie 124 Bollinger, Robert 148 Csikszentmihályi, Christopher 109

251 Speaker and Session Chair Index for Plenary, Symposium, Meet the Professors and Mid-Day Sessions The number(s) following individual’s name refers to session number.

Jacquerioz, Frederique 68 Liang, Song 9 Mwenesi, Halima 119 Rolain, Jean-Marc 17 Jamison, Dean 2 Libman, Michael 95 Mzilahowa, Themba 118 Rollinson, David 87 Jentes, Emily 117 Lie, Reidar 166 Roscigno, Giorgio 58 John, Chandy 70 Lietman, Thomas 32 N Rout, Jonathan 155 Joy, Deirdre 160 Lindblade, Kim 172 Rowland, Mark 51 Linehan, Mary 97 Nahlen, Bernard 30 Ruebush, Trenton 30 K Lines, Jo 129 Nasrin, Dilruba 41A Rujumba, Joseph 57 Little, Susan 153 Nataro, James 41A Ryan, Edward 70A, 83 Kabatereine, Narcis 76 Llinas, Manuel 8 Nene, Vishvanath 12 Kabuluzi, Storn 100 Lohia, Anuradha 37 Nesin, Mirjana 61 S Kalayanarooj, Siripen 156 Long, Carole 82 Newman, Robert 122 Kappe, Stefan 26, 80, 94 Loucq, Christian 29 Newton, Paul 17 Sabot, Oliver 165 Karunaweera, Nadira 160 Loukas, Alex 123 Nicholson, William 4, 153 Sakamoto, Joyce 12 Kasubi, Mabula 43 LoVerde, Philip 28 Noor, Abdisalan 108 Sall, Amadou 171 Katunguka, Eli 37 Lozano-Fuentes, Saul 157 Nothdurft, Hans 81 Santosham, Mathuram 180 Kazura, James 79, 82 Luby, Stephen 173, 180 Null, Clair 173 Sauerwein, Robert 94 Kent, Rebekah 7, 84 Lustigman, Sara 123 Saul, Allan 56 Khan, Shahid 94 Lynch, Matthew 128 O Savioli, Lorenzo 97 Kiang, Richard 136 Schountz, Tony 46 Kima, Peter 88 M Ockenhouse, Chris 98 Schwartz, Eli 135, 140 Kimaiyo, Sylvester 48 O’Connell, Kathryn 165 Scott, Thomas 143 Kimerling, Michael 58 Macdonald, Michael 118 Okumu, Fredros 40 Selanikio, Joel 148 King, Christopher 1, 82, 115, 161 Macedo De Oliveira, Alexandre 45 Olds, Richard 126 Seto, Edmund 9 King, Charles 87 Macete, Eusebio 100 Oliveira, Guilherme 99 Shaffer, Douglas 98 Kirker, Mary 22 Mackenzie, Charles 155 Olsen, Sonja 35 Shlim, David 135 Kirkness, Ewen 12 Magill, Alan 3 Olson, Carol 14 Sibley, Carol 45 Kissinger, Jessica 99 Maguire, Jason 25, 78 Onapa, Ambrose 97 Siegel, Cathi 79 Kitron, Uriel 129 Malone, John 42 Ottesen, Eric 97 Simmerman, Mark 172 Klein, Sabra 46 Mandel, Jeffrey 126 Sina, Barbara 22, 37, 119, 133, 166 Kochar, Sanjay Kumar 160 Marano, Nina 59 P Sinden, Robert 29, 53 Koenker, Hannah 128 Marinotti, Osvaldo 152 Singh, Upinder 8 Kokwaro, Gilbert 37 Marsh, Kevin 28, 82 Pal, Shanti 85 Slutsker, Lawrence 53, 71 Kolaczinski, Jan 76 Massung, Robert 4 Panganiban, Antonito 46 Smith, David 15, 108 Kolivras, Korine 42 Mathieu, Els 155 Panosian, Claire 2 Smith, James 48 Koroma, Joseph 97 Maude, Richard 15 Paris, Daniel 17 Sohani, Salim 128 Kortepeter, Mark 33 Mbacham, Wilfred 28, 85 Paris, Mark 44 Soulaymani, Rachida 85 Kotloff, Karen 41A McGovern, Victoria 55, 106 Parola, Philippe 140 Sow, Samba 160A Kramarik, Jean 55 McGowan, John 11 Patton, Sharon 153 Srikiatkhachorn, Anon 156 Kramer, Laura 84 McKerrow, James 141 Paz Soldan, Valerie 177 Staples, Erin 59 Krause, Peter 186 McLean, Don 96 Peatey, Chris 19 Stauffer, William 70A Kron, Michael 126 McLellan, Susan 81 Peeling, Rosanna 44, 111 Steele, Duncan 160A Ksiazek, Thomas 96, 151 McManus, Donald 123 Phetsouvanh, Rattanaphone 17 Steketee, Richard 122 Kumar, Nirbhay 29 McQuiston, Jennifer 153 Plebanski, Magdalena 41 Stephens, Peter 100 Kumar, Nandini 166 Memish, Ziad 117 Plowe, Christopher 53, 161 Stewart, Chris 126 Kumar, Sanjai 186 Meyer, Jason 12 Podda, Audino 40A Stollar, Victor 7 Kumwenda, Newton 28 Michael, Nelson 98 Polhemus, Mark 98 Su, Xinzhuan 106 Kunene, Simon 137 Mihaylova, Borislava 57 Politis, Alexander 22 Sullivan, David 43 Kwiatkowski, Dominic 106 Milhous, Wilbur 44, 102 Poumerol, Gilles 59 Sundar, Shyam 3 Miller, Mark 52A, 168 Powers, Ann 84 Sur, Dipika 40 L Mills, James 177 Price, Ric 19 Milner, Dan 164 T LaBeaud, Angelle 84 Mintz, Eric 56 R Lajous, Martin 109 Moe, Christine 102 Talaat, Maha 172 Lammie, Patrick 124 Rabary, Iarimalanto 128 Tanner, Marcel 37, 53 Möhrle, Jörg 141 Ram, Pavani 173 Lanzaro, Gregory 181 Molyneux, Malcolm 57, 164 Tarleton, Rick 63, 75 LaPrairie, André 174 Razuri, Hugo 177 Tasker, Sybil 33 Monath, Thomas 59, 96, 151, 163 Reed, Steve 44 Laserson, Kayla 71 Montgomery, Joel 177 Taylor, Diane 115 Laucella, Susana 75 Reisen, William 136 Taylor, Terrie 55, 164 Montgomery, Susan 63, 153 Reller, Megan 55 Laurens, Matthew 55 Moore, David 44, 83 Telford, Sam 186 Lavery, James 61 Remais, Justin 9 Tesh, Robert 52 Moore, Julie 115 Richards, Frank 124 Laxminarayan, Ramanan 165 Morens, David 11 Thior, Moussa 30 Lebo, Emma 172 Richie, Thomas 41 Thomas, Stephen 156 Moore, Sarah 51 Rijal, Suman 111 Lee, Yoosook 181 Morrison, Amy 143 Thompson, Joanne 19 Legge, Kevin 178 Robert, Kirkpatrick 109 Thomson, Madeleine 31 Mosser, David 107 Roberts, Donald 40 Lehane, Mike 23 Mota, Maria 160 Tibenderana, James 142 Leiby, David 63 Rodrigues, Amabelia 57 Tidwell, Richard 14 Mtove, George 43 Rodriguez, Ana 41, 178 Lescano, Andres 119, 166 Mukherjee, Joia 68 Tobias, Steven 177 Levine, Myron 41A, 52A, 56 Rogers, David 59 Todd, Charles 63 Mullan, Fitzhugh 148 Rogerson, Stephen 115 Levine, Orin 35 Muskavitch, Marc 127, 181 Tomczyk, Basia 130

252 Speaker and Session Chair Index for Plenary, Symposium, Meet the Professors and Mid-Day Sessions The number(s) following individual’s name refers to session number.

Torr, Stephen 23 Z Torreele, Els 141 Tourre, Yves 42 Zafar, Syed Nabeel 173 Tozer, David 134 Zaidi, Anita 119 Trenholme, Katharine 19 Zajac, Anne 153 Turner, Gareth 164 Zaman, K. 160A Zhou, Xiaonong 9, 42 U Ziegler, John 126 Zielinski-Gutierrez, Emily 31 Udhayakumar, Kumar 45 Zunt, Joseph 70 Ullu, Elisabetta 8 Unnasch, Thomas 124 Urbina, Julio 75 Uyeki, Tim 172

V

Van Voorhis, Wesley 99 Varmus, Harold 67 Vasilakis, Nikos 171 Vernick, Ken 90, 101 Vinetz, Joseph 79, 83, 95, 152 Volkman, Sarah 8, 127 Vulule, John 71

W

Walker, Edward 40 Walker, Richard 21 Walther, Michael 41 Wang, David 35 Waning, Brenda 100 Ward, Brian 95 Waterman, Steve 174 Webster, Joanne 76 Wellems, Thomas 1, 67, 105, 161 Werbovetz, Karl 14 Were, Martin 48 Wesson, Dawn 61 West, Sheila 32, 43 White, Chris 128 White, Graham 129 White, Nicholas 164 Whiteford, Linda 102 Whitworth, Jimmy 37 Wilder-Smith, Annelies 140 Williams, David 103 Williams, Holly 130 Williams, Jacob 118 Winzeler, Elizabeth 106 Wirth, Dyann 127 Wirtz, Robert 118 Woodall, Jack 13 Woods, Debra 103 Wynn, Thomas 107

X

Xueref, Serge 100

Y

Yang, Guo-Jing 9 Yao, Chaoqun 88 Yeboah-Antwi, Kojo 142 Yeh, Daniel 102 Yoon, In-Kyu 98, 143, 156 Yuda, Masao 90 Yuill, Thomas 96

253

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NAME OF INSTITUTION SIGNATURE OF DEAN OR DEPARTMENT CHAIR DATE 255 www.astmh.org Hotel Floorplan

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LOBBY LEVEL (FIRST FLOOR) WARDMAN MEETING ROOMS TOWER BUILDING

Capitol Boardroom Room 8212 Embassy Delaware A Room 8216 Ethan Allen Delaware B Room 8217 Nathan Hale Maryland A (Speaker Ready Room) Room 8218 (Meeting Room Sign-Up) Thomas Paine Salon 1 Room 8219 (Meeting Room Sign-Up) Salon 2 Room 8222 Salon 3 Room 8223 Salon Foyer (Registration) Room 8228 (Press Room) Virginia AB Room 8229 (Press Room) Virginia C Room 8210 Room 8211

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Exhibit Hall A (Exhibit Hall) Exhibit Hall B South (Poster Hall) Washington 1 Washington 2 Washington 3 Washington 4 Washington 5 Washington 6

258