Carbocisteine Sodium (BANM, Rinnm) Preparations Cai2 = 293.9

Brovanexine Hydrochloride (rINNM) Brovanexine, Chlorhydrate de; Brovanexini Hydrochloridum; CH O Hidrocloruro de brovanexina. 4-(Acetyloxy)-N-[2,4-dibromo-6- 3 HNH2 [(cyclohexylmethylamino)methyl]phenyl]-3-methoxybenzamide SOH monohydrochloride. O HO N CH3 Брованексина Гидрохлорид O C24H29Br2ClN2O4 = 604.8. O CH CAS — 54340-61-3 (brovanexine); 54340-60-2 (brovan- 3 Pharmacopoeias. In Chin., Eur. (see p.vii), and Jpn. exine hydrochloride). (butetamate) Ph. Eur. 6.2 (Carbocisteine). A white or almost white, crystal- line powder. Practically insoluble in water and in alcohol; dis- solves in dilute mineral acids and in dilute solutions of alkali hy- CH3 Profile Butetamate citrate is reported to be an antispasmodic and bron- droxides. A 1% suspension in water has a pH of 2.8 to 3.0. N chodilator and has been used alone or in combination prepara- Protect from light. tions for the symptomatic treatment of coughs and other associ- Incompatibility. UK licensed product information states that ated respiratory-tract disorders. mixing carbocisteine with pholcodine linctus causes precipita- H3C Preparations tion of carbocisteine from solution but no information is given on Br NH O whether this incompatibility is with the pholcodine or some com- Proprietary Preparations (details are given in Part 3) ponent of the formulation used. O Arg.: Heliphenicol. Br O Multi-ingredient: Arg.: Febrigrip; Fugafebril; Kiper; Mejoral Grip; Muco Cortos†; Mucoprednibron; Piritos; Pulmocler; Refenax Jarabe; Tavinex An- Carbocisteine Lysine (BANM, rINNM) O CH3 tigripal; Austria: Coldadolin; Influbene; Switz.: Bronchotussine. Carbocisteína lisina; Carbocistéine Lysine; Carbocisteinum Lysi- num; Carbocysteine Lysine. (brovanexine) Карбоцистеина Лизин Calcium Iodide CAS — 49673-81-6. Profile Calcii Iodidum; Calciumjodid; Ioduro de calcio; Kalcio jodidas; Kal- ATC — R05CB03. Brovanexine is a derivative of bromhexine (above) and is given siumjodidi. ATC Vet — QR05CB03. orally as the hydrochloride, usually as an adjunct to antibacterials in preparations for the treatment of respiratory-tract infections. Йодид Кальция Carbocisteine Sodium (BANM, rINNM) Preparations CaI2 = 293.9. CAS — 10102-68-8. Carbocisteína sódica; Carbocistéine Sodique; Carbocysteine So- Proprietary Preparations (details are given in Part 3) Braz.: Bronquimucil; Port.: Bronquimucil†; Pulmo-San†; Spain: Broncimu- Pharmacopoeias. Eur. (see p.vii) includes the tetrahydrate for dium; Natrii Carbocisteinum. cil. homoeopathic preparations. Натрий Карбоцистеин Ph. Eur. 6.2 (Calcium Iodide Tetrahydrate for Homoeopathic Multi-ingredient: Arg.: Trifamox Bronquial; Spain: Bronquimucil†; Eu- CAS — 49673-84-9 (carbocisteine sodium, L-form). pen Bronquial. Preparations; Calcii Iodidum Tetrahydricum ad Praeparationes ATC — R05CB03. . A white or almost white, very hygroscopic, Homoeopathicas) ATC Vet — QR05CB03. powder. Very soluble to freely soluble in water and in alcohol. Store in airtight containers. Butamirate Citrate (BANM, USAN, rINNM) Adverse Effects and Precautions Abbott-36581; Butamirát-citrát; Butamirate, Citrate de; Butami- Profile Nausea and gastric discomfort, and gastrointestinal Calcium iodide has been used orally in expectorant mixtures. rati Citras; Butamyrate Citrate; Citrato de butamirato; HH-197. The limitations of iodides as expectorants are discussed under bleeding have occasionally occurred with carbo- 2-(2-Diethylaminoethoxy)ethyl 2-phenylbutyrate dihydrogen cit- Cough, p.1547. The actions of the iodides are discussed under cisteine. Skin rashes have also been reported. rate. Iodine (p.2169). Carbocisteine should be used with caution in patients Бутамирата Цитрат Homoeopathy. Calcium iodide has been used in homoeopath- with a history of peptic ulcer disease because of the risk C18H29NO3,C6H8O7 = 499.6. ic medicines under the following names: Calcium iodatum; Cal- CAS — 18109-80-3 (butamirate); 18109-81-4 (butami- cium jodatum; Calcarea iodata; Cal. iod. that mucolytics may disrupt the gastric mucosal barri- rate citrate). er. ATC — R05DB13. Preparations ATC Vet — QR05DB13. Proprietary Preparations (details are given in Part 3) Effects on endocrine function. Transient hypothyroidism associated with the use of carbocisteine developed in a patient with Multi-ingredient: Arg.: Zantril†; Gr.: Vitreolent; USA: Calcidrine; Nori- 1 sodrine with Calcium Iodide. compromised thyroid function. 1. Wiersinga WM. Antithyroid action of carbocisteine. BMJ 1986; CH3 293: 106. H3C N Caramiphen Edisilate (BANM, rINNM) O CH Pharmacokinetics 3 Caramiphen Edisylate; Caramiphène, Edisilate de; Caramipheni Carbocisteine is rapidly and well absorbed from the Edisilas; Edisilato de caramifeno. 2-Diethylaminoethyl 1-phenylcy- gastrointestinal tract with peak plasma concentrations O clopentane-1-carboxylate ethane-1,2-disulphonate. occurring about 2 hours after an oral dose. It appears to Карамифена Эдизилат O penetrate into lung tissue and respiratory mucus. Car- C38H60N2O10S2 = 769.0. bocisteine is excreted in the urine as unchanged drug (butamirate) CAS — 77-22-5 (caramiphen); 125-86-0 (caramiphen edisilate); 125-85-9 (caramiphen hydrochloride). and metabolites. Acetylation, decarboxylation, and Profile sulfoxidation have been identified as the major meta- Butamirate citrate is a cough suppressant used in non-productive bolic pathways. Sulfoxidation may be governed by CH3 cough (p.1547) and stated to have a central action. The usual oral O genetic polymorphism. dose is up to 30 mg daily in 3 or 4 divided doses; some countries ◊ References. permit up to 90 mg daily in divided doses. Modified-release tab- N CH3 lets containing 50 mg have been given 2 or 3 times daily. O 1. Karim EFIA, et al. An investigation of the metabolism of S-carboxymethyl-L-cysteine in man using a novel HPLC-ECD meth- Preparations od. Eur J Drug Metab Pharmacokinet 1988; 13: 253–6. (details are given in Part 3) 2. Brockmoller J, et al. Evaluation of proposed sulphoxidation Proprietary Preparations pathways of carbocysteine in man by HPLC quantification. Eur Arg.: Dosodos; Talasa NF; Tossec; Belg.: Quintex†; Sinecod; Braz.: Bese- (caramiphen) J Clin Pharmacol 1991; 40: 387–92. dan†; Cz.: Sinecod; Tussin; Gr.: Antis; Antitoss; Betavix; Boutavixal; Bron- chofyl; Butacodin; Butagan; Butamir; Butrin; Buvastin; Chemisolv; Chributan; 3. Steventon GB. Diurnal variation in the metabolism of S-car- Codexine-R; Codimin; Cyne†; Devix; Doctamine; Drosten; Ellisek-S; Ger- Profile boxymethyl-L-cysteine in humans. Drug Metab Dispos 1999; totus; Leogumil; Mebronol; Minatuss; Nontoss; Novamir; Oaxen; Pandigal; Caramiphen is a centrally acting cough suppressant that has been 27: 1092–7. Pintal; Roctylan; Rondover; Safarol; Sinecod; Siroflex; Stilex; Velkacet; Veroc- 4. Jovanovic D, et al. A comparative bioavailability study of a ge- od; Vilvom; Zeleven; Zestapron†; Zetapron; Hung.: NeoCitran Antitussive; used as the edisilate in combination preparations for coughs neric capsule formulation containing carbocysteine. Pharmazie Sinecod; Ital.: Butiran; Lenistar; Lexosedin; Sinecod Tosse Sedativo; Neth.: (p.1547). Caramiphen hydrochloride was originally used simi- 2006; 61: 446–9. Sinecod; Philipp.: Sinecod; Pol.: Sinecod; Supremin; Port.: Sinecod; Rus.: larly to trihexyphenidyl (p.820) for its antimuscarinic actions. Sinecod (Синекод); Switz.: DemoTussol; NeoCitran Antitussif; Sinecod; Thai.: Sinecod; Turk.: Kreval; Sinecod. Uses and Administration Multi-ingredient: Arg.: Muco Dosodos; Braz.: Novotussan†; Cz.: Stop- Carbocisteine is used for its mucolytic activity in respi- tussin; Rus.: Stoptussin (Стоптуссин); Switz.: Hicoseen. ratory disorders associated with productive cough Carbocisteine (BAN, rINN) (p.1547). It is given orally in a dose of 750 mg three AHR-3053; Carbocisteína; Carbocistéine; Carbocisteinum; Car- times daily, reduced by one-third when a response is Butetamate Citrate (BANM, rINNM) bocysteine (USAN); Karbocistein; Karbocisteinas; Karbocisztein; obtained. Carbocisteine is also given orally as the sodi- Karbocystein; Karbocysteina; Karbosisteiini; Karbosistein; LJ-206. Butétamate, Citrate de; Butetamati Citras; Butethamate Citrate; um or lysine salts. Butethamate Dihydrogen Citrate; Citrato de butetamato. 2-Di- S-Carboxymethyl-L-cysteine. ethylaminoethyl 2-phenylbutyrate citrate. Карбоцистеин For children’s doses, see Administration in Children, below. Бутетамата Цитрат C5H9NO4S = 179.2. CAS — 2387-59-9; 638-23-3 (carbocisteine, L-form). C16H25NO2,C6H8O7 = 455.5. Administration in children. Children from 2 to 5 years may CAS — 14007-64-8 (butetamate); 13900-12-4 (buteta- ATC — R05CB03. be given oral carbocisteine 62.5 to 125 mg four times daily and mate citrate). ATC Vet — QR05CB03. those aged 5 to 12 years 250 mg three times daily. The symbol † denotes a preparation no longer actively marketed The symbol ⊗ denotes a substance whose use may be restricted in certain sports (see p.vii) 1554 Cough Suppressants Expectorants Mucolytics and Nasal Decongestants Chronic obstructive pulmonary disease. The value of mu- Profile Preparations colytic therapy in chronic obstructive pulmonary disease Clobutinol hydrochloride is a centrally acting cough suppressant Proprietary Preparations (details are given in Part 3) (COPD—p.1112) is controversial. Two studies have reported for non-productive cough (p.1547) that has been given orally in some improvements in lung function in patients with chronic doses of 40 to 80 mg three times daily; it has also been given by Multi-ingredient: Ital.: Localyn. bronchitis given carbocisteine for up to 6 months,1,2 but it ap- subcutaneous, intramuscular, or intravenous injection. However, peared to have no effect on the number of acute exacerbations.1 the EMEA has recommended for its withdrawal due to the risk However, later studies3,4 have reported reductions in the number of QT interval prolongation. Cloperastine (rINN) of acute exacerbations; the number of common colds was also Preparations Cloperastina; Clopérastine; Cloperastinum; HT-11. 1-{2-[(p- lower in the carbocisteine group in one of the studies.4 Carbo- Chloro-α-phenylbenzyl)oxy]ethyl}piperidine. cisteine may also produce some beneficial effects on sputum rhe- Proprietary Preparations (details are given in Part 3) ology.2,5 Arg.: Proking; Silomat†; Austria: Silomat†; Belg.: Silomat†; Braz.: Silo- Клоперастин mat†; Chile: Broncodual; Calfetos; Clobatos†; Cloval; Pulbronc Simple; Si- C H ClNO = 329.9. 1. Grillage M, Barnard-Jones K. Long-term oral carbocisteine ther- lomat†; Cz.: Silomat†; Fin.: Mixtus; Silomat†; Fr.: Silomat†; Ger.: Husten- 20 24 apy in patients with chronic bronchitis: a double blind trial with stiller†; Nullatuss†; Rofatuss†; Silomat†; stas-Hustenstiller N†; Tussed†; Gr.: CAS — 3703-76-2 (cloperastine); 132301-89-4 (levoclop- placebo control. Br J Clin Pract 1985; 39: 395–8. Silomat†; Ital.: Silomat-Fher†; Malaysia: Silomat†; Port.: Silomat†; Singa- erastine). 2. Aylward M, et al. Clinical evaluation of carbocisteine (Mucolex) pore: Silomat†; Thai.: Silomat†; Venez.: Silomat†. ATC — R05DB21. in the treatment of patients with chronic bronchitis: a double- ATC Vet — QR05DB21. blind trial with placebo control. Clin Trials J 1985; 22: 36–44. Multi-ingredient: Arg.: Bronquisedan; Bronquisedan Mucolitico; Braz.: Hytos Plus; Silomat Plus†; Chile: Broncodual Compuesto; Cloval Com- 3. Allegra L, et al. Prevention of acute exacerbations of chronic puesto; Pulbronc; Solvanol; Tusabron; Vapoflu; Fr.: Silomat†; Indon.: Silo- obstructive bronchitis with carbocysteine lysine salt monohy- mat Compositum; S.Afr.: Silomat DA†; UAE: Orcinol; Venez.: Silomat drate: a multicenter, double-blind, placebo-controlled trial. Res- Compositum†. piration 1996; 63: 174–80. N 4. Yasuda H, et al. Carbocisteine reduces frequency of common colds and exacerbations in patients with chronic obstructive pul- O monary disease. J Am Geriatr Soc 2006; 54: 378–80. Clofedanol Hydrochloride (BANM, rINNM) 5. Braga PC, et al. Identification of subpopulations of bronchitic patients for suitable therapy by a dynamic rheological test. Int J Chlophedianol Hydrochloride (USAN); Clofédanol, Chlorhydrate Clin Pharmacol Res 1989; IX: 175–82. de; Clofedanoli Hydrochloridum; Hidrocloruro de clofedanol; Preparations SL-501. 2-Chloro-α-(2-dimethylaminoethyl)benzyl alcohol hy- Proprietary Preparations (details are given in Part 3) drochloride. Arg.: Mucolitic; Salvitos; Belg.: Bronchathiol†; Muco Rhinathiol; Mu- Клофеданола Гидрохлорид Cl costeine†; Romilar Mucolyticum; Siroxyl; Soludril Expectorans; Braz.: Car- bocin; Carbofan; Carbotoss; Carboxil†; Certuss; Fluitoss; Fluizan†; Mucocis; C17H20ClNO,HCl = 326.3. Mucocistein; Mucofan; Mucoflux; Mucolab; Mucolisil; Mucolitic; Mucolix; CAS — 791-35-5 (clofedanol); 511-13-7 (clofedanol hy- Mucotoss; Chile: Coldin; Cz.: Fenorin; Mucopront†; Pectodrill; Rhinathiol†; drochloride). Cloperastine Fendizoate (rINNM) Fin.: Reodyn; Toclapekt†; Fr.: Actifed Expectorant†; Bronchathiol; Bron- ATC — R05DB10. chokod; Broncoclar; Broncorinol Expectorant†; Bronkirex†; Codotussyl Ex- Clopérastine, Fendizoate de; Cloperastine Hydroxyphenylben- pectorant; Dimotapp Expectorant†; Drill Expectorant; Ergix; Exotoux; Flu- ATC Vet — QR05DB10. zoyl Benzoic Acid; Cloperastine Phendizoate; Cloperastini Fend- ditec; Fluvic; Humex Expectorant; Muciclar; Pectosan Expectorant; izoas; Fendizoato de cloperastina. Pharmakod expectorant; Rhinathiol; Sirop des Vosges Expectorant†; So- lutricine Expectorant†; Toclase Expectorant†; Tussilene†; Ger.: Muco- Cl Клоперастина Фендизоат CH3 pront†; Sedotussin muco†; Transbronchin; Gr.: Allstam; Bronchiole†; Cefla- C20H24ClNO,C20H14O4 = 648.2. vit†; Chilvax; Divalio†; Duxil; Ectofus; Estival; Mucorem†; Mucothiol; CAS — 85187-37-7 (cloperastine fendizoate); 220329- Pneumol; Pulmoclase; Santamex-Expectorant†; Santamex†; Trusil; Hong N Kong: Fluifort; Mucospect; Purasol; Rhinathiol; Solmux; Hung.: Drill Expec- 19-1 (levocloperastine fendizoate). torant; Fenorin; Mucopront; NeoCitran Expectorant; Rhinathiol; Solucis; In- CH3 ATC — R05DB21. don.: Broncholit; Mucocil; Solmux; Irl.: Benylin Clear Action; Exputex; Mu- OH ATC Vet — QR05DB21. codyne; Mucogen; Mucolex; Pulmoclase; Viscolex; Israel: Mical; Mucolit; Mucomed; Ital.: Broncomucil; Bronx†; Carbocit; Fluifort; Lisomucil; Muco- cis; Mucojet†; Mucolase; Mucostar; Mucotreis; Polifluidil†; Polimucil; Reomu- Cloperastine Hydrochloride (rINNM) cil†; Sinecod Tosse Fluidificante; Solucis; Tossefluid†; Jpn: Mucodyne; Ma- Clopérastine, Chlorhydrate de; Cloperastini Hydrochloridum; laysia: Fluifort; Kastipron; Mucopront†; Pabron Cough; Rhinathiol; SCMC; (clofedanol) Mex.: Arbistin; Mucolin; Neth.: Dampo Solvopect; Mucodyne; Pectocold; Hidrocloruro de cloperastina. Rami Slijmoplossende; Rhinathiol; Philipp.: Abluent; Aflem; Ameustyn; Клоперастина Гидрохлорид Bromycil; Broncocent; Broxytone; Carboflem; Carbosol; Cysdexpel; Emux- Pharmacopoeias. In Jpn. el; Esboxyl; Fayerex; Fluralex; Genecar; Lofenin; Loviscol; Mediphlegm; Per- C20H24ClNO,HCl = 366.3. tussin; Phlegmol; Solmux; Solplem; Trimulex; Westcarbox; Zylotin; Zymelyt- Profile CAS — 14984-68-0. ic; Pol.: Mukolina; PectoDrill; Port.: Drill Mucolitico; Finatux; Mucolex; Clofedanol hydrochloride is a centrally acting cough suppressant ATC — R05DB21. Mucorespiral; Mucorhinathiol Infantil; Mucorhinathiol Mucoral; Pulmiben; for non-productive cough (p.1547) that has been given in oral ATC Vet — QR05DB21. Pulmoclase†; Rus.: Bronchobos (Бронхобос); Fluditec (Флюдитек); Flui- fort (Флуифорт); Mucodin (Мукодин); S.Afr.: Acuphlem; Betaphlem; doses of 25 mg three or four times daily. For children’s doses, see Pharmacopoeias. In Jpn. Bronchette; Co-Flem; Flemex; Flemgo; Flemlite; Lessmusec; Medphlem; Administration in Children, below. Mucocaps†; Mucoflem; Mucoless; Mucolinct; Mucosirop†; Mucospect; Sin- Profile gapore: Mucopront†; Rhinathiol; SCMC; Spain: Actithiol; Anatac; Fluidin Administration in children. The following oral doses of Cloperastine is primarily a centrally acting cough suppressant Mucolitico; Iniston Mucolitico; Mucovital; Pectodrill; Pectox; Viscoteina; clofedanol hydrochloride have been recommended for children: used for non-productive cough (p.1547). It also has some antihis- Switz.: Mephathiol; Mucogeran†; Mucoseptal†; Pectox; Rhinathiol; Tus- • 2 to 6 years: 12.5 mg 3 or 4 times daily santiol; Thai.: Amicof; Bocytin; Carbocter; Carbomed; Cisteine†; Exflem; taminic action. The hydrochloride has been given orally as tab- Flemex; Fluifort; I-Cof; Mucolex; Mucomex; Mucopront†; Muflex; Murhinal; • 6 to 12 years: 12.5 to 25 mg 3 or 4 times daily lets in usual doses of 10 to 20 mg three times daily. Cloperastine Rhinathiol; Rhinex; Siflex; Solmux; Throatsil-CBS; Turk.: Mucocis; Mukoliz; fendizoate is used in oral liquid preparations in equivalent doses. Mukotik; UK: Mucodyne; Venez.: Broxolflem; Cisteinol†; Gulaper; Loganil; Preparations Cloperastine fendizoate 17.7 mg is equivalent to about 10 mg of Loviscol; Mucofar; Mucopront. Proprietary Preparations (details are given in Part 3) cloperastine hydrochloride. Levocloperastine fendizoate has Multi-ingredient: Arg.: Mucolitic Antitusivo†; Polimucil†; Fr.: Rhinathiol Canad.: Ulone; Hong Kong: Coldrin†; Singapore: Coldrin†; Spain: been used similarly. Promethazine; Gr.: Carbozor; Flemagon; Grupozil; Gutman; Mucostein; Gentos†. Pneumol Plus; Polimucil; Respinorm; Sevlenyl; Sobrein; Sorbexyl; Vanesin; ◊ References. Hong Kong: Mucosin; Rhinathiol Promethazine; India: Caceff; Carbomox; Multi-ingredient: Arg.: Bronco Biotaer†; Causalon Bronquial; Cofron; Gentiabron†; Neo-Tosel†; Notozen; Pectoral Hebert; Selectus FN; Torfan 1. Aliprandi P, et al. Levocloperastine in the treatment of chronic Moxycarb-DT†; Ital.: Broncofluid; Keraflex; Libexin Mucolitico; Malaysia: nonproductive cough: comparative efficacy versus standard an- Mucoease Plus; Rhinathiol Promethazine; SCMC Promethazine†; Mex.: H†; Toxam†; Toxambay; Chile: Bauxol; Brontal; Cofron†; Diadicon; Kolibel; Mucolin A; Philipp.: Solmux-Broncho (Reformulated); Port.: Bronquial; Mucobrol. titussive agents. Drugs Exp Clin Res 2004; 30: 133–41. Niflux; Singapore: Rhinathiol Promethazine; Spain: Actithiol Antihist; Preparations Bronquicisteina; Eduprim Mucolitico; Switz.: Rhinathiol Promethazine; Tri- ofan. Proprietary Preparations (details are given in Part 3) Clonazoline Hydrochloride (rINNM) ⊗ Belg.: Lysotossil; Novotossil†; Sekin; Braz.: Seki; Hong Kong: Uncough; Ital.: Cloel; Clofend; Mitituss; Nitossil; Politosse; Privituss; Quik; Seki; Jpn: Clonazoline, Chlorhydrate de; Clonazolini Hydrochloridum; Hid- Hustazol; Malaysia: Copastin; Mex.: Privituss; Port.: Tecnofox; Spain: Flutox; Sekisan. Clobutinol Hydrochloride (rINNM) rocloruro de clonazolina. 2-[(4-Chloro-1-naphthyl)methyl]-2-im- Multi-ingredient: Thai.: Hustazol-C†. Clobutinol, Chlorhydrate de; Clobutinoli Hydrochloridum; Hid- idazoline hydrochloride. rocloruro de clobutinol; KAT-256. 2-(4-Chlorobenzyl)-3- Клоназолина Гидрохлорид (dimethylaminomethyl)butan-2-ol hydrochloride. C H ClN ,HCl = 281.2. 14 13 2 Cocillana Клобутинола Гидрохлорид CAS — 17692-28-3 (clonazoline); 23593-08-0 (clonazoline hydrochloride). Grape Bark; Guapi Bark; Huapi Bark. C14H22ClNO,HCl = 292.2. CAS — 14860-49-2 (clobutinol); 1215-83-4 (clobutinol Коккилана hydrochloride). CAS — 1398-77-2. ATC — R05DB03. Profile ATC Vet — QR05DB03. Cocillana is the dried bark of Guarea guidonia (G. rusbyi, Syco- N carpus rusbyi, G. trichilioides; Meliaceae), a South American tree. It is used as an expectorant similarly to ipecacuanha CH3 HN (p.1562). It has been used in large doses as an emetic. N Cl Preparations CH 3 (clonazoline) Proprietary Preparations (details are given in Part 3) Cl Fin.: Codetabs. CH3 Multi-ingredient: Braz.: Elixir de Marinheiro†; Canad.: Alsidrine†; Sirop HO Profile Cocillana Codeine; Sirop Cocillana Compose; Fin.: Codesan Comp; Code- CH3 Clonazoline hydrochloride is a sympathomimetic with effects san N†; Hong Kong: Coci-Fedra; Coci-Fedra-C; Cocillana Christo; Cocil- similar to those of naphazoline (p.1565) used for its vasocon- lana Compound; Dextrocilla; Eurocilana; Mefedra-N†; Ital.: Broncosedina; (clobutinol) strictor activity in the local treatment of nasal congestion S.Afr.: Cocillana Co; Corbar; Swed.: Cocillana-Etyfin; Venez.: Cerylana. (p.1548).