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Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer
cancers Review Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer Viktoriia Cherkasova, Olga Kovalchuk * and Igor Kovalchuk * Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 7X8, Canada; [email protected] * Correspondence: [email protected] (O.K.); [email protected] (I.K.) Simple Summary: In recent years, multiple preclinical studies have shown that changes in endo- cannabinoid system signaling may have various effects on intestinal inflammation and colorectal cancer. However, not all tumors can respond to cannabinoid therapy in the same manner. Given that colorectal cancer is a heterogeneous disease with different genomic landscapes, experiments with cannabinoids should involve different molecular subtypes, emerging mutations, and various stages of the disease. We hope that this review can help researchers form a comprehensive understanding of cannabinoid interactions in colorectal cancer and intestinal bowel diseases. We believe that selecting a particular experimental model based on the disease’s genetic landscape is a crucial step in the drug discovery, which eventually may tremendously benefit patient’s treatment outcomes and bring us one step closer to individualized medicine. Abstract: Despite the multiple preventive measures and treatment options, colorectal cancer holds a significant place in the world’s disease and mortality rates. The development of novel therapy is in Citation: Cherkasova, V.; Kovalchuk, critical need, and based on recent experimental data, cannabinoids could become excellent candidates. O.; Kovalchuk, I. Cannabinoids and This review covered known experimental studies regarding the effects of cannabinoids on intestinal Endocannabinoid System Changes in inflammation and colorectal cancer. In our opinion, because colorectal cancer is a heterogeneous Intestinal Inflammation and disease with different genomic landscapes, the choice of cannabinoids for tumor prevention and Colorectal Cancer. -
CZECH MYCOLOGY Formerly Česká Mykologie Published Quarterly by the Czech Scientific Society for Mycology
r 7|— I VOLUME 48 L ^ Z - t U M M A Y 1 9 9 5 My c o l o g y l CZECH SCIENTIFIC SOCIETY FOR MYCOLOGY PRAHA JSAYCU N l . o Clov J < M ^/\YCU ISSN 0009-0476 n§ ! r % . O o v J < Vol. 48, No. 1, May 1995 CZECH MYCOLOGY formerly Česká mykologie published quarterly by the Czech Scientific Society for Mycology EDITORIAL BOARD Editor-in-Chief ZDENĚK POUZAR (Praha) Managing editor ; JAROSLAV KLÁN (Praha) VLADIMÍR ANTONÍN (Brno) JIŘÍ KUNERT (Olomouc) OLGA FASSATIOVÁ (Praha) LUDMILA MARVANOVÁ (Brno) ROSTISLAV FELLNER (Praha) PETR PIKÁLEK (Praha) JOSEF HERINK (Mnichovo Hradiště) MIRKO SVRČEK (Praha) Czech Mycology is an international scientific journal publishing papers in all aspects of mycology. Publication in the journal is open to members of the Czech Scientific Society for Mycology and non-members. Contributions to: Czech Mycology, National Museum, Department of Mycology, Václavské nám. 68, 115 79 Praha 1, Czech Republic. Phone: 02/24230485 SUBSCRIPTION. Annual subscription is Kč 250,- (including postage). The annual sub scription for abroad is US $80,- (including postage). The annual membership fee of the Czech Scientific Society for Mycology (Kč 160,- or US $ 60,- for foreigners) includes the journal without any other additional payment. For subscriptions, address changes, pay ment and further information please contact The Czech Scientific Society for Mycology, P.O.Box 106, 11121 Praha 1, Czech Republic. Copyright © The Czech Scientific Society for Mycology, Prague, 1995 : No. 4 of the vol. 47 of Czech Mycology appeared in February 16, 1995 CZECH MYCOLOGY Publication of the Czech Scientific Society for Mycology Volume 48 May 1995 Number 1 Articles published in this number of Czech Mycology were presented at 7th International Congress of Mycology Division (IUMS - 94) in Prague, July 3 - 8, 1994. -
Krafts Sieg Am Kulm Ging Eine Geduldsprobe Voraus
28 Sport Nummer 47 | Montag, 17. Februar 2020 Kurzmeldungen Krafts Sieg am Kulm ging eine Geduldsprobe voraus Nach nur einem Flug und einigem Zuwarten im dann abgebrochenen zweiten Durchgang war der erste Heim-Sieg für Stefan Kraft Gewissheit. Bad Mitterndorf – Stefan Kraft hat es am Sonntag mit Der neue Silberpfeil wurde bereits in der Vorwoche präsentiert und wird nur einem Flug geschafft, ab Mittwoch in Barcelona (ESP) an den Tests teilnehmen. Foto: Daimler AG erstmals in Österreich ei- nen Weltcup-Triumph zu feiern. Der 26-jährige Salz- Drei Formel-1-Teams lassen burger siegte nach Rang drei am Vortag auf dem Kulm bei jetzt noch die Hüllen fallen Bad Mitterndorf nach einem 230-m-Flug im ersten Durch- Mondsee, Barcelona – Ra- Stroll lüftet heute am Mond- gang nur 0,7 Punkte vor dem cing Point, Williams (bei- see, bei Hauptsponsor BWT, Japaner Ryoyu Kobayashi. de heute) und Alfa Romeo den Vorhang. Am Mittwoch Der zweite Durchgang muss- (Mittwoch)präsentierendie- (bis Freitag) finden dann die te wegen zu starken Windes se Woche noch ihre neuen ersten Testfahrten des Jah- drei Springer vor dem Ende Formel-1-Boliden. Vor allem res statt. Traditionell wird annulliert werden: Nach ei- bei Racing Point schwingt dabei wieder in Barcelona nem 159-m-Hüpfer des nach ein Hauch von Rotweißrot (ESP) im Kreis gefahren. Der dem ersten Durchgang viert- mit: Das Team des kanadi- Saisonstart fällt auf den 15. platzierten Polen Kamil Stoch schen Milliardärs Lawrence März (Australien). (TT) entschied sich die Jury wegen starken Rückenwindes zum Abbruch. „Es ist sicher einer der schönsten Siege, sicher Mayer muss Fury verglich Wilder mit ein bisserl einem Beige- erneut vor Gericht mit Klitschko Innsbruck – Der bereits im Hamburg – Der ehemalige August 2011 vom Wiener Boxweltmeister Tyson Fu- Straflandesgericht nach ry hat eine Woche vor der dem Anti-Doping- sowie WBC-Weltmeisterschaftsei- dem Arzneimittel-Ge- nen Rivalen Deontay Wilder setz verurteilte ehemali- mit dem Ex-Champion Wla- ge ÖSV-Skilanglauf- und dimir Klitschko verglichen. -
Motor Competence in Visually Impaired Persons
See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/341870616 Motor competence in visually impaired persons Book · January 2019 DOI: 10.5507/ftk.19.24455549 CITATIONS READS 0 20 2 authors, including: Janečka Zbyněk Palacký University Olomouc 15 PUBLICATIONS 19 CITATIONS SEE PROFILE Some of the authors of this publication are also working on these related projects: dis HBSC - monitoring of lifestyle of students with special education needs View project Centra podpory integrace / Center of inclusion support View project All content following this page was uploaded by Janečka Zbyněk on 27 November 2020. The user has requested enhancement of the downloaded file. Palacký University Olomouc Faculty of Physical Culture Motor competence in visually impaired persons Zbyněk Janečka Ladislav Bláha et al. Olomouc 2019 Reviewers: Ken Black Maria Dinold First Edition Unauthorized use of the work is a breach of copyright and may be subject to civil, administrative or criminal liability. © Zbyněk Janečka, Ladislav Bláha, 2019 © Palacký University Olomouc, 2019 DOI: 10.5507/ftk.19.24455549 ISBN 978-80-244-5554-9 (print) ISBN 978-80-244-5555-6 (online : PDF) Content 1 / Terminology (Janečka, Bláha) ............................................................................................................7 2 / Type of impairment and its categorisation (Bláha) ..........................................................................11 3 / Vision (Janečka) .................................................................................................................................15 -
Preventive Aspects of Early Nutrition Nestlé Nutrition Institute Workshop Series
Preventive Aspects of Early Nutrition Nestlé Nutrition Institute Workshop Series Vol. 85 Preventive Aspects of Early Nutrition Editors Mary S. Fewtrell London, UK Ferdinand Haschke Salzburg, Austria Susan L. Prescott Perth, Australia Nestec Ltd., 55 Avenue Nestlé, CH–1800 Vevey (Switzerland) S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland) www.karger.com Library of Congress Cataloging-in-Publication Data Names: Fewtrell, Mary S., editor. | Haschke, F., editor. | Prescott, Susan L., editor. Title: Preventive aspects of early nutrition / editors, Mary S. Fewtrell, Ferdinand Haschke, Susan L. Prescott. Description: Basel ; New York : Karger, [2016] | Series: Nestlé Nutrition Institute workshop series, ISSN 1664-2147 ; vol. 85 | Includes bibliographical references and index. Identifiers: LCCN 2015046033| ISBN 9783318056426 (hard cover : alk. paper) | ISBN 9783318056433 (electronic version) Subjects: | MESH: Child Nutritional Physiological Phenomena | Infant Nutritional Physiological Phenomena | Pediatric Obesity--prevention & control | Hypersensitivity--prevention & control | Congresses Classification: LCC RJ206 | NLM WS 130 | DDC 613.2083--dc23 LC record available at http://lccn.loc.gov/2015046033 The material contained in this volume was submitted as previously unpublished material, except in the instances in which credit has been given to the source from which some of the illustrative material was derived. Great care has been taken to maintain the accuracy of the information contained in the volume. However, neither Nestec Ltd. nor S. Karger AG can be held responsible for errors or for any consequences arising from the use of the information contained herein. © 2016 Nestec Ltd., Vevey (Switzerland) and S. Karger AG, Basel (Switzerland). All rights reserved. This book is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, or recording, or otherwise, without the written permission of the publisher. -
Iii. Administración Local
BOCM BOLETÍN OFICIAL DE LA COMUNIDAD DE MADRID Pág. 468 LUNES 21 DE MARZO DE 2011 B.O.C.M. Núm. 67 III. ADMINISTRACIÓN LOCAL AYUNTAMIENTO DE 17 MADRID RÉGIMEN ECONÓMICO Agencia Tributaria Madrid Subdirección General de Recaudación En los expedientes que se tramitan en esta Subdirección General de Recaudación con- forme al procedimiento de apremio, se ha intentado la notificación cuya clave se indica en la columna “TN”, sin que haya podido practicarse por causas no imputables a esta Administra- ción. Al amparo de lo dispuesto en el artículo 112 de la Ley 58/2003, de 17 de diciembre, Ge- neral Tributaria (“Boletín Oficial del Estado” número 302, de 18 de diciembre), por el presen- te anuncio se emplaza a los interesados que se consignan en el anexo adjunto, a fin de que comparezcan ante el Órgano y Oficina Municipal que se especifica en el mismo, con el obje- to de serles entregada la respectiva notificación. A tal efecto, se les señala que deberán comparecer en cualquiera de las Oficinas de Atención Integral al Contribuyente, dentro del plazo de los quince días naturales al de la pu- blicación del presente anuncio en el BOLETÍN OFICIAL DE LA COMUNIDAD DE MADRID, de lunes a jueves, entre las nueve y las diecisiete horas, y los viernes y el mes de agosto, entre las nueve y las catorce horas. Quedan advertidos de que, transcurrido dicho plazo sin que tuviere lugar su compare- cencia, se entenderá producida la notificación a todos los efectos legales desde el día si- guiente al del vencimiento del plazo señalado. -
Persbest Men 20170615.Xlsx
Personal Best List Surname Name Country Distance (m) Place Year Kraft Stefan Austria (AUT) 253.5 Vikersund 2017 Johansson Robert Norway (NOR) 253.0 Vikersund 2017 Fannemel Anders Norway (NOR) 251.5 Vikersund 2015 Stoch Kamil Poland (POL) 251.5 Planica 2017 Prevc Peter Slovenia (SLO) 250.0 Vikersund 2015 Stjernen Andreas Norway (NOR) 249.0 Vikersund 2016 Gangnes Kenneth Norway (NOR) 248.5 Vikersund 2016 Eisenbichler Markus Germany (GER) 248.0 Planica 2017 Evensen Johan Remen Norway (NOR) 246.5 Vikersund 2011 Żyła Piotr Poland (POL) 245.5 Vikersund 2017 Forfang Johann André Norway (NOR) 245.5 Vikersund 2017 Freund Severin Germany (GER) 245.0 Vikersund 2015 Wellinger Andreas Germany (GER) 245.0 Planica 2017 Bickner Kevin United States of America (USA) 244.5 Vikersund 2017 Kranjec Robert Slovenia (SLO) 244.0 Vikersund 2012 Tepeš Jurij Slovenia (SLO) 244.0 Planica 2015 Kot Maciej Poland (POL) 244.0 Vikersund 2017 Schlierenzauer Gregor Austria (AUT) 243.5 Vikersund 2011 Geiger Karl Germany (GER) 243.5 Planica 2017 Prevc Domen Slovenia (SLO) 243.5 Vikersund 2017 Velta Rune Norway (NOR) 243.0 Vikersund 2012 Hauer Joachim Norway (NOR) 243.0 Vikersund 2016 Tande Daniel-André Norway (NOR) 242.0 Vikersund 2016 Koch Martin Austria (AUT) 241.5 Vikersund 2011 Hayböck Michael Austria (AUT) 241.5 Planica 2015 Kasai Noriaki Japan (JPN) 241.5 Vikersund 2017 Happonen Janne Finland (FIN) 240.0 Vikersund 2011 Itō Daiki Japan (JPN) 240.0 Vikersund 2012 Takeuchi Taku Japan (JPN) 240.0 Vikersund 2016 Ammann Simon Switzerland (SUI) 239.5 Vikersund 2011 Romøren -
Smiths Abound Discussion Document
Smiths Abound According to Wikipedia, Smith is the most common surname in the United Kingdom, Australia and the United States, and second only to Li in Canada. It is the fifth most common surname in Ireland. Worldwide there are about 5 million Smiths; data on how many live in the U.S.is conflicting, but at least 2.4 million. Therefore, it’s not surprising that people who bear the surname Smith have chosen to have their own holiday on January 6. The event seems to have been started by Adrienne Sioux Koopersmith in 1995, in part to find help in tracing her own genealogy. She chose January 6th because it was the birthday in 1580 of Captain John Smith, the English colonial leader who helped to settle Jamestown, Virginia in 1607, thereby bringing the name to North American shores. The word “smith” derives from the word “smite” or “strike,” and although there has been a suggestion that Smiths originally derived their name from the occupation of soldiers (smiting the enemy), most present day Smiths are probably descendants of blacksmiths who worked with black metals, such as iron. Related names include: • Whitesmith and Tinsmith for those who worked with tin • Coppersmith (or in Adrienne’s case) Koopersmith for those who worked with copper, and Brownsmith, Redsmith, and Greensmith for the color of copper when it oxidized • Silversmith and Goldsmith, obviously for those who worked with silver and gold In addition, of course, there are people named Smythe, Smithers, Smitherman, Smithson, or Smithwick, all related in one way or another to their laboring ancestors. -
And Oxidative Stress in the Differentiation of SH-SY5Y Cells
Hernandez-Martinez, Juan-Manuel (2015) Role of kynurenines and oxidative stress in the differentiation of SH-SY5Y cells. PhD thesis. http://theses.gla.ac.uk/6133/ Copyright and moral rights for this thesis are retained by the author A copy can be downloaded for personal non-commercial research or study, without prior permission or charge This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the Author The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the Author When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given Glasgow Theses Service http://theses.gla.ac.uk/ [email protected] Role of Kynurenines and Oxidative Stress in the Differentiation of SH-SY5Y Cells Juan-Manuel Hernandez-Martinez B.Sc. (UNAM) A thesis submitted in fulfilment of the requirements for the Degree of PhD Institute of Neuroscience and Psychology College of Medical, Veterinary and Life Sciences University of Glasgow September 2014 Abstract Neuroblastoma is the most common solid extracranial tumour in children. The neuroblastoma SH-SY5Y cell line is a third successive subclone established from a metastatic bone tumour biopsy. It can be induced to differentiate (regress) into a neuronal phenotype when treated with any of several molecules including retinoic acid (RA). This characteristic has been exploited in several studies that use the SH-SY5Y cell line as a neuronal model. These studies have had far- reaching implications in shaping our understanding of certain key aspects of neurotoxicity and neurodevelopment yet their genuine relevance becomes evident when approached from an oncological point of view, as they provide information about the process underlying tumour regression which in turn can lead to the development of better therapies for the clinical management of this malignancy. -
Annual Report 2008-2009
annual report 09 v4:Layout 1 11/8/2010 9:39 AM Page 1 Western Reserve Academy Annual Report 2008-2009 Behind each student and faculty member lie the loyalty, generosity and strength of the entire Western Reserve Academy community. annual report 09 v4:Layout 1 11/8/2010 9:39 AM Page 2 2008-2009 Board of Trustees Mark R. Tercek ’75, Daniel W. Christman ’61 Andrew R. Midler ’79 Douglas Kurdziel ’05, Co-president Alexandria, Va. St. Thomas, U.S. Virgin College Trustee Irvington, N.Y. Kathryn I. Clark ’76 Islands Nashville, Tenn. Peter S. Hellman ’68, Ann Arbor, Mich. Katie Ong-Landini ’83 Cookie Richardson, Co-president Ruth Swetland Eppig Shaker Heights, Ohio Pioneer Women President Hunting Valley, Ohio Bratenahl, Ohio Gregory Pennington ’71 Hudson, Ohio Stephan W. Cole ’66, Dagmar F. Fellowes ’75 Milwaukee, Wis. Lorraine Debose ’93, Vice President Pepper Pike, Ohio R. Lawrence Roth Alumni Association President Jupiter, Fla. New York, N.Y. Euclid, Ohio John M. Fowler ’67 Trustee Emeriti David M. Hunter ’68, Bronxville, N.Y. Hewitt B. Shaw Vice President Hudson, Ohio H. Arthur Bellows Jr. ’56 Silver Lake, Ohio Anne C. Goodman ’84 Shaker Heights, Ohio Shannah Tharp-Taylor ’91 Greenwich, Conn. Richard W. Neu, Ronald M. Harrington ’87 Pittsburgh, Pa. Jefferson W. Keener Jr. ’50 Treasurer Akron, Ohio Naples, Fla. Hudson, Ohio Jason M. Wortendyke ’94 Olin J. Heestand Jr. ’62 Chicago, Ill. T. Dixon Long ’51 Fred A. Cummings ’85, San Anselmo, Calif. Assistant Treasurer Chicago, Ill. Special Trustees Moreland Hills, Ohio Nathaniel E. Leonard ’82 David J. -
Søndre Green, Kunst- Og Kulturgården Under Norefjell Den Nye Ms Kryllingen • Fjelltur Med Barn
GRATISMAGASIN [ SOMMER 2017 ] SØNDRE GREEN, KUNST- OG KULTURGÅRDEN UNDER NOREFJELL DEN NYE MS KRYLLINGEN • FJELLTUR MED BARN 1 NOREFJELL.COM NOREFJELLMAGASINET 2 3 FOTO OLAV GOLBERG OLAV FOTO INNHOLD Leder 6 Mitt Norefjell, strømførende ordfører 12 Søndre Green, kunst- og kulturgården under Norefjell 16 Noreheim, setra hvor det meste er kortreist 19 16 Bjørneparken økte besøket med 50 % 22 Buskerudmuseet 24 Galleri Skredsvik, suksess fra dag en 25 Th. Kittelsen, fra skisser til ferdige tegninger 26 SETERLIV Villa Fridheim, eventyrslott og kulisse 27 Krøderbanen på bedre skinner 28 JAKTEN PÅ EN AKTIV FERIE Folkemusikk, tømmer og korn 29 31 Den nye MS Kryllingen 31 Veikåker gård, en opplevelse for store og små 35 Velkommen til en aktiv ferie med fjelltur, fiske, ridning, golf, kano, strand med Ut på tur, aldri sur 36 vollyball, fotball- og minigolfbane, klatrevegg, treningsrom, basseng med boblebad Krøderen kro & motell 41 og sauna, samt spa- og velværeavdeling. De fleste aktiviteter er inkludert i prisen. Høgevarde hytteområde 42 Aktiviteter Blaafarveværket med ny attraksjon i koboltgruvene 44 4-sengsleilighet Aktivitetskontor med utlån av kanoer, baller og diverse spill Fra fiskevær til høyfjell 47 47 med 2 soverom, bad, stue og kjøkken Filmer, barnesone og buldrevegg Fjelltur med barn utenfor allfarvei 51 1 uke 5.190,- / 4 dager 3.190,- Klatrekonkurranse, quiz, skattejakt og barnedisco Fotball- og bandyturnering Gokart i 31 år 52 6(8)-sengsleilighet Guidede fjellturer Fjellgourmet, men ikke bare det 55 med 3 soverom, bad, stue og kjøkken Åpen seter daglig med bemannet kiosk 18 hull rett under Norefjell 57 1 uke 7.190,- / 4 dager 5.190,- Dyr på seteren: 2 esler, 6-7 geiter, kaniner, høner, killinger og hester Stell, foring og melking av dyrene Vikersundbakken 60 Leilighetene har høy standard og inkl. -
Lrtsv27no3.Pdf
EDITORIATBOARD Editor,andChairpersonoJtheEditoriatBoard. .. Er-rzesl.rlrL'Tare AssistantEditors Psvllrs A RrcnrroNo .for Cataloging and Classification Section Eow,A,noSwaNsoN Cenorvr C. Monnow for Presewation of Library Materials Section FneNcrsF. SpnErrznr for Reproduction of Library Materials Section Section J. Mrcueel Bnuen for Resources LrNor Sepp for Serials Section Editorial Adoisu: Donts H Cr-acx (for Regional Groups) Liaisonuith RTSD Newsletter: Atrqor-o HrnsnoN, RTSD NewsletterEditor Library ResourcesI TechnicalSerares (ISSN 0024-252?), the quarterly official publication ofthe Resourcesand Technical ServicesDivision of the American Library Association,is publishedat 50 E.HuronSt.,Chicago, IL60611. BusinessOffice:AmericanLibraryAssociation,50E.HuronSt., Chicago, IL 60611. Aduntising Tralfic Coordinator;Leona Swiech, Central Production Unit, ALA Headquarters,50E. HuronSt., Chicago, IL60611. CirculationandProduction:Central Production Unit{turnals, ALA Headquarters,50 E. Huron St., Chicago,IL 60611 . SubscriptionPrice. to mem- bersof the ALA Resourcesand Technical ServicesDivision, $10 per year, included in the member- ship dues; to nonmembers, $20 per year; singlecopies $5. Second-classpostage paid at Chicago, Illinois, and at additional mailing offices.POSTMAS- TER: Send addiess changes to Librarl ResourcesI TechnicalSeruices, 50 E. Huron St., Chicago, IL 6061I Librar2 ResourcesI TechnicalSeraices is indexed in Library Literature,Librarl I InformationScience Index- Con- Absmai, CurrentIndex toJournals in Education, ScienceCitation Index, and Hospital Literature tentsarelistedin CALL(CurrmtAuareness-Librar\Literature).ItsreviewsareincludedinBookRetieu Digest,Book Reouw Infux, and Retieu of Reuieus Copies of books for review should be addressedto Arnold Hirshon, Editor, R ZSD Newsletter,Ca- bell Library, virginia commonwealth ljniversity, 901 Park Ave., Richmond, VA 23284. Do not send journal issuesor journal articles for review. The contents of this journal, unless otheruise indicated, are copyrighted by the Association.