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Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer
cancers Review Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer Viktoriia Cherkasova, Olga Kovalchuk * and Igor Kovalchuk * Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 7X8, Canada; [email protected] * Correspondence: [email protected] (O.K.); [email protected] (I.K.) Simple Summary: In recent years, multiple preclinical studies have shown that changes in endo- cannabinoid system signaling may have various effects on intestinal inflammation and colorectal cancer. However, not all tumors can respond to cannabinoid therapy in the same manner. Given that colorectal cancer is a heterogeneous disease with different genomic landscapes, experiments with cannabinoids should involve different molecular subtypes, emerging mutations, and various stages of the disease. We hope that this review can help researchers form a comprehensive understanding of cannabinoid interactions in colorectal cancer and intestinal bowel diseases. We believe that selecting a particular experimental model based on the disease’s genetic landscape is a crucial step in the drug discovery, which eventually may tremendously benefit patient’s treatment outcomes and bring us one step closer to individualized medicine. Abstract: Despite the multiple preventive measures and treatment options, colorectal cancer holds a significant place in the world’s disease and mortality rates. The development of novel therapy is in Citation: Cherkasova, V.; Kovalchuk, critical need, and based on recent experimental data, cannabinoids could become excellent candidates. O.; Kovalchuk, I. Cannabinoids and This review covered known experimental studies regarding the effects of cannabinoids on intestinal Endocannabinoid System Changes in inflammation and colorectal cancer. In our opinion, because colorectal cancer is a heterogeneous Intestinal Inflammation and disease with different genomic landscapes, the choice of cannabinoids for tumor prevention and Colorectal Cancer. -
CZECH MYCOLOGY Formerly Česká Mykologie Published Quarterly by the Czech Scientific Society for Mycology
r 7|— I VOLUME 48 L ^ Z - t U M M A Y 1 9 9 5 My c o l o g y l CZECH SCIENTIFIC SOCIETY FOR MYCOLOGY PRAHA JSAYCU N l . o Clov J < M ^/\YCU ISSN 0009-0476 n§ ! r % . O o v J < Vol. 48, No. 1, May 1995 CZECH MYCOLOGY formerly Česká mykologie published quarterly by the Czech Scientific Society for Mycology EDITORIAL BOARD Editor-in-Chief ZDENĚK POUZAR (Praha) Managing editor ; JAROSLAV KLÁN (Praha) VLADIMÍR ANTONÍN (Brno) JIŘÍ KUNERT (Olomouc) OLGA FASSATIOVÁ (Praha) LUDMILA MARVANOVÁ (Brno) ROSTISLAV FELLNER (Praha) PETR PIKÁLEK (Praha) JOSEF HERINK (Mnichovo Hradiště) MIRKO SVRČEK (Praha) Czech Mycology is an international scientific journal publishing papers in all aspects of mycology. Publication in the journal is open to members of the Czech Scientific Society for Mycology and non-members. Contributions to: Czech Mycology, National Museum, Department of Mycology, Václavské nám. 68, 115 79 Praha 1, Czech Republic. Phone: 02/24230485 SUBSCRIPTION. Annual subscription is Kč 250,- (including postage). The annual sub scription for abroad is US $80,- (including postage). The annual membership fee of the Czech Scientific Society for Mycology (Kč 160,- or US $ 60,- for foreigners) includes the journal without any other additional payment. For subscriptions, address changes, pay ment and further information please contact The Czech Scientific Society for Mycology, P.O.Box 106, 11121 Praha 1, Czech Republic. Copyright © The Czech Scientific Society for Mycology, Prague, 1995 : No. 4 of the vol. 47 of Czech Mycology appeared in February 16, 1995 CZECH MYCOLOGY Publication of the Czech Scientific Society for Mycology Volume 48 May 1995 Number 1 Articles published in this number of Czech Mycology were presented at 7th International Congress of Mycology Division (IUMS - 94) in Prague, July 3 - 8, 1994. -
Iii. Administración Local
BOCM BOLETÍN OFICIAL DE LA COMUNIDAD DE MADRID Pág. 468 LUNES 21 DE MARZO DE 2011 B.O.C.M. Núm. 67 III. ADMINISTRACIÓN LOCAL AYUNTAMIENTO DE 17 MADRID RÉGIMEN ECONÓMICO Agencia Tributaria Madrid Subdirección General de Recaudación En los expedientes que se tramitan en esta Subdirección General de Recaudación con- forme al procedimiento de apremio, se ha intentado la notificación cuya clave se indica en la columna “TN”, sin que haya podido practicarse por causas no imputables a esta Administra- ción. Al amparo de lo dispuesto en el artículo 112 de la Ley 58/2003, de 17 de diciembre, Ge- neral Tributaria (“Boletín Oficial del Estado” número 302, de 18 de diciembre), por el presen- te anuncio se emplaza a los interesados que se consignan en el anexo adjunto, a fin de que comparezcan ante el Órgano y Oficina Municipal que se especifica en el mismo, con el obje- to de serles entregada la respectiva notificación. A tal efecto, se les señala que deberán comparecer en cualquiera de las Oficinas de Atención Integral al Contribuyente, dentro del plazo de los quince días naturales al de la pu- blicación del presente anuncio en el BOLETÍN OFICIAL DE LA COMUNIDAD DE MADRID, de lunes a jueves, entre las nueve y las diecisiete horas, y los viernes y el mes de agosto, entre las nueve y las catorce horas. Quedan advertidos de que, transcurrido dicho plazo sin que tuviere lugar su compare- cencia, se entenderá producida la notificación a todos los efectos legales desde el día si- guiente al del vencimiento del plazo señalado. -
Smiths Abound Discussion Document
Smiths Abound According to Wikipedia, Smith is the most common surname in the United Kingdom, Australia and the United States, and second only to Li in Canada. It is the fifth most common surname in Ireland. Worldwide there are about 5 million Smiths; data on how many live in the U.S.is conflicting, but at least 2.4 million. Therefore, it’s not surprising that people who bear the surname Smith have chosen to have their own holiday on January 6. The event seems to have been started by Adrienne Sioux Koopersmith in 1995, in part to find help in tracing her own genealogy. She chose January 6th because it was the birthday in 1580 of Captain John Smith, the English colonial leader who helped to settle Jamestown, Virginia in 1607, thereby bringing the name to North American shores. The word “smith” derives from the word “smite” or “strike,” and although there has been a suggestion that Smiths originally derived their name from the occupation of soldiers (smiting the enemy), most present day Smiths are probably descendants of blacksmiths who worked with black metals, such as iron. Related names include: • Whitesmith and Tinsmith for those who worked with tin • Coppersmith (or in Adrienne’s case) Koopersmith for those who worked with copper, and Brownsmith, Redsmith, and Greensmith for the color of copper when it oxidized • Silversmith and Goldsmith, obviously for those who worked with silver and gold In addition, of course, there are people named Smythe, Smithers, Smitherman, Smithson, or Smithwick, all related in one way or another to their laboring ancestors. -
And Oxidative Stress in the Differentiation of SH-SY5Y Cells
Hernandez-Martinez, Juan-Manuel (2015) Role of kynurenines and oxidative stress in the differentiation of SH-SY5Y cells. PhD thesis. http://theses.gla.ac.uk/6133/ Copyright and moral rights for this thesis are retained by the author A copy can be downloaded for personal non-commercial research or study, without prior permission or charge This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the Author The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the Author When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given Glasgow Theses Service http://theses.gla.ac.uk/ [email protected] Role of Kynurenines and Oxidative Stress in the Differentiation of SH-SY5Y Cells Juan-Manuel Hernandez-Martinez B.Sc. (UNAM) A thesis submitted in fulfilment of the requirements for the Degree of PhD Institute of Neuroscience and Psychology College of Medical, Veterinary and Life Sciences University of Glasgow September 2014 Abstract Neuroblastoma is the most common solid extracranial tumour in children. The neuroblastoma SH-SY5Y cell line is a third successive subclone established from a metastatic bone tumour biopsy. It can be induced to differentiate (regress) into a neuronal phenotype when treated with any of several molecules including retinoic acid (RA). This characteristic has been exploited in several studies that use the SH-SY5Y cell line as a neuronal model. These studies have had far- reaching implications in shaping our understanding of certain key aspects of neurotoxicity and neurodevelopment yet their genuine relevance becomes evident when approached from an oncological point of view, as they provide information about the process underlying tumour regression which in turn can lead to the development of better therapies for the clinical management of this malignancy. -
Sports Figures Price Guide
SPORTS FIGURES PRICE GUIDE All values listed are for Mint (white jersey) .......... 16.00- David Ortiz (white jersey). 22.00- Ching-Ming Wang ........ 15 Tracy McGrady (white jrsy) 12.00- Lamar Odom (purple jersey) 16.00 Patrick Ewing .......... $12 (blue jersey) .......... 110.00 figures still in the packaging. The Jim Thome (Phillies jersey) 12.00 (gray jersey). 40.00+ Kevin Youkilis (white jersey) 22 (blue jersey) ........... 22.00- (yellow jersey) ......... 25.00 (Blue Uniform) ......... $25 (blue jersey, snow). 350.00 package must have four perfect (Indians jersey) ........ 25.00 Scott Rolen (white jersey) .. 12.00 (grey jersey) ............ 20 Dirk Nowitzki (blue jersey) 15.00- Shaquille O’Neal (red jersey) 12.00 Spud Webb ............ $12 Stephen Davis (white jersey) 20.00 corners and the blister bubble 2003 SERIES 7 (gray jersey). 18.00 Barry Zito (white jersey) ..... .10 (white jersey) .......... 25.00- (black jersey) .......... 22.00 Larry Bird ............. $15 (70th Anniversary jersey) 75.00 cannot be creased, dented, or Jim Edmonds (Angels jersey) 20.00 2005 SERIES 13 (grey jersey ............... .12 Shaquille O’Neal (yellow jrsy) 15.00 2005 SERIES 9 Julius Erving ........... $15 Jeff Garcia damaged in any way. Troy Glaus (white sleeves) . 10.00 Moises Alou (Giants jersey) 15.00 MCFARLANE MLB 21 (purple jersey) ......... 25.00 Kobe Bryant (yellow jersey) 14.00 Elgin Baylor ............ $15 (white jsy/no stripe shoes) 15.00 (red sleeves) .......... 80.00+ Randy Johnson (Yankees jsy) 17.00 Jorge Posada NY Yankees $15.00 John Stockton (white jersey) 12.00 (purple jersey) ......... 30.00 George Gervin .......... $15 (whte jsy/ed stripe shoes) 22.00 Randy Johnson (white jersey) 10.00 Pedro Martinez (Mets jersey) 12.00 Daisuke Matsuzaka .... -
Journeys with Judah Halevi, Ignatius Loyola and Malcolm X
ON PILGRIMAGE: Journeys with Judah Halevi, Ignatius Loyola and Malcolm X Patrick J. Ryan, S.J. Laurence J. McGinley Professor of Religion and Society Fordham University INTRODUCTION My first pilgrimage took place sixty years ago, in the fall of my freshman year in high school. With my fellow pilgrims I traveled by train from New York City to Auriesville, New York, a village in the Mohawk River Valley. Six decades ago, all the Jesuit institutions in and around New York City hired a full train so that students, staff and other friends of the Jesuits could travel together on pilgrimage to the Shrine of the North American Martyrs at Auriesville on the Sunday in the fall nearest to their feast. That is October 19th now, but September 26th then. Who were the North American martyrs? Eight French Jesuit missionaries who died violent deaths in the 1640s in what is now Canada and New York State. Needless to say, their martyrdom not only testified to their faith but also, quite realistically, to the forebodings the Iroquois Confederacy harbored about encroaching French presence in the middle of the seventeenth century. Our pilgrimage to Auriesville in 1953 was not all prayer and solemnity, I assure you, although there were both at the mass in the Martyrs’ Shrine that Sunday, and along the paths that took us past trees marked with simple crosses and the name of Jesus, imitating a practice once followed in the Mohawk village of Ossernenon by Isaac Jogues, René Goupil and Jean de la Lande in the 1640s. But the train ride on either end of the visit to Auriesville was more 1 fun, as I recall. -
Noms De Famille Issus De L'artisanat En France Et En Pologne
ROCZNIKI HUMANISTYCZNE Tom LXVI, zeszyt 8 – 2019 DOI: http://dx.doi.org/10.18290/rh.2019.67.8-5 IWONA PIECHNIK1 NOMS DE FAMILLE ISSUS DE L’ARTISANAT EN FRANCE ET EN POLOGNE SURNAMES FROM ARTISAN NAMES IN FRANCE AND IN POLAND Abstract The article analyses surnames originating from artisan names in France and in Poland. It presents their origins (including foreign influences), types and word formation. We can see, among other things, that the French surnames are shorter, but have many dialectal variants, while the Polish surnames are longer and have a richer derivation. The article also focuses on demographic statis- tics of such surnames in both countries: the blacksmith as an etymon is the most popular. In the top 50, there are also in France: baker, miller and mason; while in Poland: tailor and shoemaker. Key words: family names; surnames; patronyms; handicraft; artisan. Les plus anciens noms de famille issus des domaines de l’artisanat en France et en Pologne remontent au Moyen Âge, donc à l’époque où le sys- tème féodal se renforçait et les villes commençaient à se développer, en nourrissant surtout les ambitions des nobles de construire leurs demeures seigneuriales, et des gens de petits métiers venaient s’installer tout autour naturellement. Dans des bourgs, c’est-à-dire dans de gros villages où se te- naient ordinairement des marchés, les bourgeois bénéficiaient d’un statut privilégié et développaient le commerce et la conjoncture de la manufacture, donc il y avait aussi beaucoup de travail pour différents métiers. C’est juste- ment dans les bourgs et les villes que l’artisanat se développait le mieux, en 1 Dr hab. -
Download This PDF File
254 LRTS 51(4) Family Names and the Cataloger By Laurence S. Creider The Joint Steering Committee for the Revision of the Anglo-American Cataloguing Rules has indicated that the replacement for the Anglo-American Cataloguing Rules, 2nd ed., to be known as Resource Description and Access, will allow the use of family names as authors and will provide rules for their formation. This paper discusses what a family name describes; examines how information seekers look for family names and what they expect to find; describes the ways in which family names have been established in Anglo-American cataloging and archival traditions; asks how adequately the headings established under these rules help users find such information; and suggests how revised cataloging rules might bet- ter enable users to identify resources that meet their needs. escriptive catalogers have devoted a great deal of time over the last century Dto deciding how to establish personal names and corporate names, but they have largely ignored family names. Anglo-American cataloging codes have been based on the notion that authorship is the best basis for organizing access to works, and many library catalogers have not considered the possibility that families can be capable of authorship. One looks in vain for a discussion of families as points of entry or as headings in the comparative studies of cataloging codes written by Pettee, Hanson, or Ranganathan.1 The Paris Principles adopted in 1961 do not even mention the word family.2 This state of affairs has persisted from the days of Cutter through the various Anglo-American cataloging codes, as a glance at Laurence Creider ([email protected]. -
Progress Report Annual Report on Reactor Safety Research Projects
Gesellschaft für Anlagen- und Reaktorsicherheit (GRS) mbH DE05FF049 Progress Report Annual Report on Reactor Safety Research Projects Reporting Period 2004 Projects sponsored by the Ministry of Economics and Labour of the Federal Republic of Germany GRS - F - 2004 EN Gesellschaft für Anlagen- und Reaktorsicherheit (GRS) mbH Progress Report Annual Report on Reactor Safety Research Projects Reporting Period 2004 Projects sponsored by the Ministry of Economics and Labour of the Federal Republic of Germany GRS • F • 2004 EN Preface Within its competence for energy research, the Bundesministerium für Wirtschaft und Arbeit (BMWA) (Federal Ministry of Economics and Labour) sponsors investigations into the safety of nuclear power plants. The objective of these investigations is to provide fundamental knowledge, procedures and methods to contribute to realistic safety assessments of nuclear installations, to the further development of safety technology and to make use of the potential of innovative safety-related approaches. The Gesellschaft für Anlagen- und Reaktorsicherheit (GRS) mbH, by order of the BMWA, continuously issues information on the status of such investigations by publishing semi-annual and annual progress reports within the series of GRS-F-Fortschrittsberichte (GRS-F-Progress Reports). Each progress report represents a compilation of individual reports about the objectives, work performed, results achieved, next steps of the work etc. The individual reports are prepared in a standard form by the research organizations themselves as documentation of their progress in work. The progress reports are published by the Research Management Division of GRS. The compilation of the reports is classified according to the classification system "Joint Safety Research Index (JSRI)". -
World Directory of Forest Geneticistsand Tree Breeders
United States Department of World Directory of Forest Geneticists Agriculture and Tree Breeders Forest Service Pacific Southwest Annuaire mondial des généticiens et Research Station améliorateurs General Technical Report PSW-GTR- 170 Catálogo mundial de mejoradores y geneticistas InternationalesVerzeichnis der Forstgenetiker and Forstpflanzenzüchter Publisher: Pacific Southwest Research Station Albany, California Forest Service Mailing address: U.S. Department of Agriculture PO Box 245, Berkeley CA 94701-0245 (510) 559-6300 voice (510) 559-6440 Fax email: mailroom/[email protected] http://www.psw.fs.fed.us Abstract Ledig, F. Thomas; Neale, David B., compilers, 1998. World directory of forest geneticists and tree breeders. Gen. Tech. Rep. PSW-GTR-170. Albany, CA: Pacific Southwest September 1998 Research Station, Forest Service, U.S. Department of Agriculture; 189 p. A formal task of the Forest Genetic Resources Study Group/North American Forestry Commission/Food and Agriculture Organization of the United Nations and Working Party 2.04.09 / Division 2- Physiology and Genetics /International Union of Forest Research Organizations, this international directory lists more than 1,800 forest geneticists and tree breeders from 86 countries. Each listing includes the entrant's title, mailing address, phone and fax numbers, and email address, when available. Indices organize entrants by country, by alphabetical order, by taxa of interest, and by research subjects. Retrieval Terms: forest genetics The Compilers F. Thomas Ledig is senior scientist and -
Surnames of the Waldensian Valleys
Surnames of the Waldensian Valleys The following surname list is based largely on Osvaldo Coisson, I Nomi di Famiglia delle Valli Valdesi [Torre Pellice, 1975]. You should photocopy each Coisson article about a surname on your pedigree so you know the variations in the spelling of the name before your search other records and in which villages you should begin searching. Surnames mentioned only in early medieval records are not included on this list. NOTE: In parish and notary records, names may appear in either French or Italian forms and with many variations in spelling. Common spelling variants are in parenthesis. Abonel Acay Achard Afos Aghit (Aguiti Aguit Aghitto) Agiaton (Aguiton) Agli Agnes (De Agues) Aiello Aillard Aimar (Aymar Aymer) Aimon (Aymon) Albarea (Arbarea Arbareta Arbrea Ala Albamo Albare) Albarin (Arbarin Arbarino Albarino) Alberge Alberguin Alberti (Albert Alberge Albergia Alberico Albertengo Aliberti) Allais (Alais Aillaisa Alatia Alaxia Albertin Allai Alasia) Allamburgo (Alambergo Alamborgo) Allard (Alard Alliar) Allaud Allemdandi (Alamanni Allamani Allesan (Alesan Aleysan Alleisan Alemand Alamandi Allemanno Alligmen Alesano Alesani) Alamanda) Alliet (Aillette Alliata Allieta Alieta Allevato Alliaud (Allio Allier Alier Alye Aliar) Lietta Lieta) Alliaud (Aillaut Aillaudi Agliaudo Allio Alliou Aillaud Alio Allioud Aliot Ailiaud (Aillaud Ailleaud) Alioud) Aloerio (Aloerious Alloero Alloerio Allion Allois Alouer) Amat Amberti Amphoux (Anfossi Anfoso) Amstetto (Arasetto) Anastate (Anatate Anastaze) Anastase Andreon (Andrion