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Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer
cancers Review Cannabinoids and Endocannabinoid System Changes in Intestinal Inflammation and Colorectal Cancer Viktoriia Cherkasova, Olga Kovalchuk * and Igor Kovalchuk * Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 7X8, Canada; [email protected] * Correspondence: [email protected] (O.K.); [email protected] (I.K.) Simple Summary: In recent years, multiple preclinical studies have shown that changes in endo- cannabinoid system signaling may have various effects on intestinal inflammation and colorectal cancer. However, not all tumors can respond to cannabinoid therapy in the same manner. Given that colorectal cancer is a heterogeneous disease with different genomic landscapes, experiments with cannabinoids should involve different molecular subtypes, emerging mutations, and various stages of the disease. We hope that this review can help researchers form a comprehensive understanding of cannabinoid interactions in colorectal cancer and intestinal bowel diseases. We believe that selecting a particular experimental model based on the disease’s genetic landscape is a crucial step in the drug discovery, which eventually may tremendously benefit patient’s treatment outcomes and bring us one step closer to individualized medicine. Abstract: Despite the multiple preventive measures and treatment options, colorectal cancer holds a significant place in the world’s disease and mortality rates. The development of novel therapy is in Citation: Cherkasova, V.; Kovalchuk, critical need, and based on recent experimental data, cannabinoids could become excellent candidates. O.; Kovalchuk, I. Cannabinoids and This review covered known experimental studies regarding the effects of cannabinoids on intestinal Endocannabinoid System Changes in inflammation and colorectal cancer. In our opinion, because colorectal cancer is a heterogeneous Intestinal Inflammation and disease with different genomic landscapes, the choice of cannabinoids for tumor prevention and Colorectal Cancer. -
Who Can Replace Xavi? a Passing Motif Analysis of Football Players
Who can replace Xavi? A passing motif analysis of football players. Javier Lopez´ Pena˜ ∗ Raul´ Sanchez´ Navarro y Abstract level of passing sequences distributions (cf [6,9,13]), by studying passing networks [3, 4, 8], or from a dy- Traditionally, most of football statistical and media namic perspective studying game flow [2], or pass- coverage has been focused almost exclusively on goals ing flow motifs at the team level [5], where passing and (ocassionally) shots. However, most of the dura- flow motifs (developed following [10]) were satis- tion of a football game is spent away from the boxes, factorily proven by Gyarmati, Kwak and Rodr´ıguez passing the ball around. The way teams pass the to set appart passing style from football teams from ball around is the most characteristic measurement of randomized networks. what a team’s “unique style” is. In the present work In the present work we ellaborate on [5] by ex- we analyse passing sequences at the player level, us- tending the flow motif analysis to a player level. We ing the different passing frequencies as a “digital fin- start by breaking down all possible 3-passes motifs gerprint” of a player’s style. The resulting numbers into all the different variations resulting from labelling provide an adequate feature set which can be used a distinguished node in the motif, resulting on a to- in order to construct a measure of similarity between tal of 15 different 3-passes motifs at the player level players. Armed with such a similarity tool, one can (stemming from the 5 motifs for teams). -
CZECH MYCOLOGY Formerly Česká Mykologie Published Quarterly by the Czech Scientific Society for Mycology
r 7|— I VOLUME 48 L ^ Z - t U M M A Y 1 9 9 5 My c o l o g y l CZECH SCIENTIFIC SOCIETY FOR MYCOLOGY PRAHA JSAYCU N l . o Clov J < M ^/\YCU ISSN 0009-0476 n§ ! r % . O o v J < Vol. 48, No. 1, May 1995 CZECH MYCOLOGY formerly Česká mykologie published quarterly by the Czech Scientific Society for Mycology EDITORIAL BOARD Editor-in-Chief ZDENĚK POUZAR (Praha) Managing editor ; JAROSLAV KLÁN (Praha) VLADIMÍR ANTONÍN (Brno) JIŘÍ KUNERT (Olomouc) OLGA FASSATIOVÁ (Praha) LUDMILA MARVANOVÁ (Brno) ROSTISLAV FELLNER (Praha) PETR PIKÁLEK (Praha) JOSEF HERINK (Mnichovo Hradiště) MIRKO SVRČEK (Praha) Czech Mycology is an international scientific journal publishing papers in all aspects of mycology. Publication in the journal is open to members of the Czech Scientific Society for Mycology and non-members. Contributions to: Czech Mycology, National Museum, Department of Mycology, Václavské nám. 68, 115 79 Praha 1, Czech Republic. Phone: 02/24230485 SUBSCRIPTION. Annual subscription is Kč 250,- (including postage). The annual sub scription for abroad is US $80,- (including postage). The annual membership fee of the Czech Scientific Society for Mycology (Kč 160,- or US $ 60,- for foreigners) includes the journal without any other additional payment. For subscriptions, address changes, pay ment and further information please contact The Czech Scientific Society for Mycology, P.O.Box 106, 11121 Praha 1, Czech Republic. Copyright © The Czech Scientific Society for Mycology, Prague, 1995 : No. 4 of the vol. 47 of Czech Mycology appeared in February 16, 1995 CZECH MYCOLOGY Publication of the Czech Scientific Society for Mycology Volume 48 May 1995 Number 1 Articles published in this number of Czech Mycology were presented at 7th International Congress of Mycology Division (IUMS - 94) in Prague, July 3 - 8, 1994. -
Topps - UEFA Champions League Match Attax 2015/16 (08) - Checklist
Topps - UEFA Champions League Match Attax 2015/16 (08) - Checklist 2015-16 UEFA Champions League Match Attax 2015/16 Topps 562 cards Here is the complete checklist. The total of 562 cards includes the 32 Pro11 cards and the 32 Match Attax Live code cards. So thats 498 cards plus 32 Pro11, plus 32 MA Live and the 24 Limited Edition cards. 1. Petr Ĉech (Arsenal) 2. Laurent Koscielny (Arsenal) 3. Kieran Gibbs (Arsenal) 4. Per Mertesacker (Arsenal) 5. Mathieu Debuchy (Arsenal) 6. Nacho Monreal (Arsenal) 7. Héctor Bellerín (Arsenal) 8. Gabriel (Arsenal) 9. Jack Wilshere (Arsenal) 10. Alex Oxlade-Chamberlain (Arsenal) 11. Aaron Ramsey (Arsenal) 12. Mesut Özil (Arsenal) 13. Santi Cazorla (Arsenal) 14. Mikel Arteta (Arsenal) - Captain 15. Olivier Giroud (Arsenal) 15. Theo Walcott (Arsenal) 17. Alexis Sánchez (Arsenal) - Star Player 18. Laurent Koscielny (Arsenal) - Defensive Duo 18. Per Mertesacker (Arsenal) - Defensive Duo 19. Iker Casillas (Porto) 20. Iván Marcano (Porto) 21. Maicon (Porto) - Captain 22. Bruno Martins Indi (Porto) 23. Aly Cissokho (Porto) 24. José Ángel (Porto) 25. Maxi Pereira (Porto) 26. Evandro (Porto) 27. Héctor Herrera (Porto) 28. Danilo (Porto) 29. Rúben Neves (Porto) 30. Gilbert Imbula (Porto) 31. Yacine Brahimi (Porto) - Star Player 32. Pablo Osvaldo (Porto) 33. Cristian Tello (Porto) 34. Alberto Bueno (Porto) 35. Vincent Aboubakar (Porto) 36. Héctor Herrera (Porto) - Midfield Duo 36. Gilbert Imbula (Porto) - Midfield Duo 37. Joe Hart (Manchester City) 38. Bacary Sagna (Manchester City) 39. Martín Demichelis (Manchester City) 40. Vincent Kompany (Manchester City) - Captain 41. Gaël Clichy (Manchester City) 42. Elaquim Mangala (Manchester City) 43. Aleksandar Kolarov (Manchester City) 44. -
Smiths Abound Discussion Document
Smiths Abound According to Wikipedia, Smith is the most common surname in the United Kingdom, Australia and the United States, and second only to Li in Canada. It is the fifth most common surname in Ireland. Worldwide there are about 5 million Smiths; data on how many live in the U.S.is conflicting, but at least 2.4 million. Therefore, it’s not surprising that people who bear the surname Smith have chosen to have their own holiday on January 6. The event seems to have been started by Adrienne Sioux Koopersmith in 1995, in part to find help in tracing her own genealogy. She chose January 6th because it was the birthday in 1580 of Captain John Smith, the English colonial leader who helped to settle Jamestown, Virginia in 1607, thereby bringing the name to North American shores. The word “smith” derives from the word “smite” or “strike,” and although there has been a suggestion that Smiths originally derived their name from the occupation of soldiers (smiting the enemy), most present day Smiths are probably descendants of blacksmiths who worked with black metals, such as iron. Related names include: • Whitesmith and Tinsmith for those who worked with tin • Coppersmith (or in Adrienne’s case) Koopersmith for those who worked with copper, and Brownsmith, Redsmith, and Greensmith for the color of copper when it oxidized • Silversmith and Goldsmith, obviously for those who worked with silver and gold In addition, of course, there are people named Smythe, Smithers, Smitherman, Smithson, or Smithwick, all related in one way or another to their laboring ancestors. -
And Oxidative Stress in the Differentiation of SH-SY5Y Cells
Hernandez-Martinez, Juan-Manuel (2015) Role of kynurenines and oxidative stress in the differentiation of SH-SY5Y cells. PhD thesis. http://theses.gla.ac.uk/6133/ Copyright and moral rights for this thesis are retained by the author A copy can be downloaded for personal non-commercial research or study, without prior permission or charge This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the Author The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the Author When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given Glasgow Theses Service http://theses.gla.ac.uk/ [email protected] Role of Kynurenines and Oxidative Stress in the Differentiation of SH-SY5Y Cells Juan-Manuel Hernandez-Martinez B.Sc. (UNAM) A thesis submitted in fulfilment of the requirements for the Degree of PhD Institute of Neuroscience and Psychology College of Medical, Veterinary and Life Sciences University of Glasgow September 2014 Abstract Neuroblastoma is the most common solid extracranial tumour in children. The neuroblastoma SH-SY5Y cell line is a third successive subclone established from a metastatic bone tumour biopsy. It can be induced to differentiate (regress) into a neuronal phenotype when treated with any of several molecules including retinoic acid (RA). This characteristic has been exploited in several studies that use the SH-SY5Y cell line as a neuronal model. These studies have had far- reaching implications in shaping our understanding of certain key aspects of neurotoxicity and neurodevelopment yet their genuine relevance becomes evident when approached from an oncological point of view, as they provide information about the process underlying tumour regression which in turn can lead to the development of better therapies for the clinical management of this malignancy. -
New Challenge for Keita
WEDNESDAY, AuguSt 24, 2016 VOLuME XI ISSuE NO.29 QR2.00 www.dohastadiumplusqatar.com P 27 | FOOTBALL P 28 | BEACH VOLLEYBALL QATAR BEAT JORDAN QATAR EYE HAT-TRICK QATAR’S FIRST Qatar overcome Jordan in a friendly Holders Qatar, represented by Cherif ENGLISH SPORTS played as part of their preparations for Younousse and Jefferson Pereira, start WEEKLY Asian Zone World Cup qualification. as favourites at the Arab Championship. FOLLOW US OVER TO TOKYO PAGES 6-7 P 20 | POSTER MUTAZ ESSA BARSHIM P 26 | FOOTBALL DSP SPECIAL STORY New challenge for Keita UK £1, Europe €2 | Oman 200 Baisas | Bahrain 200 Fils | Egypt LE 2 | Lebanon 3,000 Livre | Kuwait 250 Fils | Morocco Dh 6 | UAEDh 5 | Yemen 75 Riyals | Sudan 1 Pound | KSA 2 Riyals | Jordan 500 Fils | Iraq $1 | Palestine $1 | Syria LS 20 www.dohastadiumplusqatar.com | Wednesday, August 24, 2016 www.dohastadiumplusqatar.com 3 EXCITEMENT NOW JUST A TOUCH AWAY OutlookThe writer can be contacted at [email protected] Mutaz, Akram make history as Aspire shows the way forward ĈĈThe best preparation for tomorrow pollution and the gunmen from ‘crime-ravaged Liga club when he donned the colours of Sporting is doing your best today favelas’ didn’t shoot down anybody! Gijon against Athletic Bilbao last Sunday. Rio not only overcame all such fears, but also I’m sure their monumental achievements will LL’S well that ends well, they say. The Rio managed to tide over other crises, including the inspire a lot of youngsters in our country. Hearty Olympics might’ve ended in a blaze of suspension of the country’s president. -
Constructing Artworks. Issues of Authorship and Articulation Around Seydou Keïta’S Photographs
Nordic Journal of African Studies 17(1): 34–46 (2008) Constructing artworks. Issues of Authorship and Articulation around Seydou Keïta’s Photographs. ALESSANDRO JEDLOWSKI University of Naples, Italy ABSTRACT This essay focuses on Seydou Keïta’s work, and on the way in which this work has been received and conceptualized within both the African and the Western context. These photographs have a long history of geographical and cultural displacement that has deeply influenced their status, as well as the status of the people who engaged with them. The essay follows the development of this history, dealing with the processes of construction of Seydou Keïta as an author and of his photographs as international acclaimed pieces of art. Keywords: Seydou Keita, African photography, African Contemporary Art, Authorship INTRODUCTION This essay focuses on Seydou Keïta’s work, and on the way in which the work of this Malian photographer has been received and conceptualized within both the African and the Western context. Keïta’s photographs have a long history of geographical and cultural displacement that has deeply influenced their status, as well as the status of the people who engaged with them. From a photographic studio in Bamako in the 1950’s, these portraits moved to the houses of their purchasers. At least thirty years later, some negatives moved from Keïta’s personal archive to an exhibition in the Centre for African Art of New York. Attracted by the aesthetical beauty of these portraits, André Magnin bought some negatives for the biggest collection of Contemporary African Art, the Pigozzi Collection. Finally, only few years ago, the Pigozzi Collection donated some of the photographs it owns to the National Museum of Bamako. -
2011/12 UEFA Champions League Statistics Handbook
Coaches FC Barcelona v Manchester United FC: Josep Guardiola v Sir Alex Ferguson for the second time in three seasons. Prior to kick-off at Wembley, ‘Pep’ greets the coach he admires most in a meeting between two coaches with exceptionally high averages in the UEFA Champions League. All-time leader Sir Alex was bringing his total to 176 games in 16 seasons, yet even he was falling marginally short of Pep’s tally of 38 matches in only three campaigns. PHOTO: SHAUN BOTTERILL / GETTY IMAGES Season 2011/2012 Total matches played in season Played Away Played at Home Sir Alex FERGUSON Clubs Birthdate 31.12.1941 Nationality Scottish 1994/95 Manchester United FC 6 1996/97 Manchester United FC 10 Part. P W D L F A 1997/98 Manchester United FC 8 Home: - 86 59 19 8 190 70 1998/99 Manchester United FC 11 Away: - 86 36 24 26 108 84 1999/00 Manchester United FC 14 Neutral:-411247 2000/01 Manchester United FC 14 2001/02 Manchester United FC 16 Overall: 16 176 96 44 36 302 161 2002/03 Manchester United FC 14 2003/04 Manchester United FC 8 2004/05 Manchester United FC 8 2005/06 Manchester United FC 6 2006/07 Manchester United FC 12 2007/08 Manchester United FC 13 Totals 2008/09 Manchester United FC 13 2009/10 Manchester United FC 10 2010/11 Manchester United FC 13 Played at neutral venue Part.: Participations P: Matches Played W: Matches Won D: Matches Drawn L: Matches Lost F: Goals For A: Goals Against 2 Introduction THE ELITE COACHES The 18 coaches who made their UEFA Champions League debut during the 2010/11 campaign brought the total of newcomers to 31 in just two seasons – almost half of the number of participants. -
Surname Folders.Pdf
SURNAME Where Filed Aaron Filed under "A" Misc folder Andrick Abdon Filed under "A" Misc folder Angeny Abel Anger Filed under "A" Misc folder Aberts Angst Filed under "A" Misc folder Abram Angstadt Achey Ankrum Filed under "A" Misc folder Acker Anns Ackerman Annveg Filed under “A” Misc folder Adair Ansel Adam Anspach Adams Anthony Addleman Appenzeller Ader Filed under "A" Misc folder Apple/Appel Adkins Filed under "A" Misc folder Applebach Aduddell Filed under “A” Misc folder Appleman Aeder Appler Ainsworth Apps/Upps Filed under "A" Misc folder Aitken Filed under "A" Misc folder Apt Filed under "A" Misc folder Akers Filed under "A" Misc folder Arbogast Filed under "A" Misc folder Albaugh Filed under "A" Misc folder Archer Filed under "A" Misc folder Alberson Filed under “A” Misc folder Arment Albert Armentrout Albight/Albrecht Armistead Alcorn Armitradinge Alden Filed under "A" Misc folder Armour Alderfer Armstrong Alexander Arndt Alger Arnold Allebach Arnsberger Filed under "A" Misc folder Alleman Arrel Filed under "A" Misc folder Allen Arritt/Erret Filed under “A” Misc folder Allender Filed under "A" Misc folder Aschliman/Ashelman Allgyer Ash Filed under “A” Misc folder Allison Ashenfelter Filed under "A" Misc folder Allumbaugh Filed under "A" Misc folder Ashoff Alspach Asper Filed under "A" Misc folder Alstadt Aspinwall Filed under "A" Misc folder Alt Aston Filed under "A" Misc folder Alter Atiyeh Filed under "A" Misc folder Althaus Atkins Filed under "A" Misc folder Altland Atkinson Alwine Atticks Amalong Atwell Amborn Filed under -
Arxiv:1810.00224V2 [Q-Bio.PE] 7 Dec 2020 Humanity Is Increasingly Influencing Global Environments [195]
A Survey of Biodiversity Informatics: Concepts, Practices, and Challenges Luiz M. R. Gadelha Jr.1* Pedro C. de Siracusa1 Artur Ziviani1 Eduardo Couto Dalcin2 Helen Michelle Affe2 Marinez Ferreira de Siqueira2 Luís Alexandre Estevão da Silva2 Douglas A. Augusto3 Eduardo Krempser3 Marcia Chame3 Raquel Lopes Costa4 Pedro Milet Meirelles5 and Fabiano Thompson6 1National Laboratory for Scientific Computing, Petrópolis, Brazil 2Friedrich-Schiller-University Jena, Jena, Germany 2Rio de Janeiro Botanical Garden, Rio de Janeiro, Brazil 3Oswaldo Cruz Foundation, Rio de Janeiro, Brazil 4National Institute of Cancer, Rio de Janeiro, Brazil 5Federal University of Bahia, Salvador, Brazil 6Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Abstract The unprecedented size of the human population, along with its associated economic activities, have an ever increasing impact on global environments. Across the world, countries are concerned about the growing resource consumption and the capacity of ecosystems to provide them. To effectively conserve biodiversity, it is essential to make indicators and knowledge openly available to decision-makers in ways that they can effectively use them. The development and deployment of mechanisms to produce these indicators depend on having access to trustworthy data from field surveys and automated sensors, biological collections, molec- ular data, and historic academic literature. The transformation of this raw data into synthesized information that is fit for use requires going through many refinement steps. The methodologies and techniques used to manage and analyze this data comprise an area often called biodiversity informatics (or e-Biodiversity). Bio- diversity data follows a life cycle consisting of planning, collection, certification, description, preservation, discovery, integration, and analysis. -
Most-Common-Surnames-Bmd-Registers-16.Pdf
Most Common Surnames Surnames occurring most often in Scotland's registers of Births, Marriages and Deaths Counting only the surname of the child for births, the surnames of BOTH PARTIES (for example both BRIDE and GROOM) for marriages, and the surname of the deceased for deaths Note: the surnames from these registers may not be representative of the surnames of the population of Scotland as a whole, as (a) they include the surnames of non-residents who were born / married / died here; (b) they exclude the surnames of residents who were born / married / died elsewhere; and (c) some age-groups have very low birth, marriage and death rates; others account for most births, marriages and deaths.ths Registration Year = 2016 Position Surname Number 1 SMITH 2056 2 BROWN 1435 3 WILSON 1354 4 CAMPBELL 1147 5 STEWART 1139 6 THOMSON 1127 7 ROBERTSON 1088 8 ANDERSON 1001 9 MACDONALD 808 10 TAYLOR 782 11 SCOTT 771 12 REID 755 13 MURRAY 754 14 CLARK 734 15 WATSON 642 16 ROSS 629 17 YOUNG 608 18 MITCHELL 601 19 WALKER 589 20= MORRISON 587 20= PATERSON 587 22 GRAHAM 569 23 HAMILTON 541 24 FRASER 529 25 MARTIN 528 26 GRAY 523 27 HENDERSON 522 28 KERR 521 29 MCDONALD 520 30 FERGUSON 513 31 MILLER 511 32 CAMERON 510 33= DAVIDSON 506 33= JOHNSTON 506 35 BELL 483 36 KELLY 478 37 DUNCAN 473 38 HUNTER 450 39 SIMPSON 438 40 MACLEOD 435 41 MACKENZIE 434 42 ALLAN 432 43 GRANT 429 44 WALLACE 401 45 BLACK 399 © Crown Copyright 2017 46 RUSSELL 394 47 JONES 392 48 MACKAY 372 49= MARSHALL 370 49= SUTHERLAND 370 51 WRIGHT 357 52 GIBSON 356 53 BURNS 353 54= KENNEDY 347