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A Stable and Safe Form of Iodine Azide: Polymer-Bound Bisazido- Iodate(I)

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A Stable and Safe Form of Iodine Azide: Polymer-Bound Bisazido- Iodate(I) SYNOPEN2509-9396 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart 2021, 5, 104–107 spotlight 104 en SynOpen V. George, A. Kirschning Spotlight A Stable and Safe Form of Iodine Azide: Polymer-Bound Bisazido- iodate(I) Vincent George 0000-0003-2594-895X Andreas Kirschning* 0000-0001-5431-6930 Institute of Organic Chemistry, Leibniz University Hannover, Schneiderberg 1B, 30167 Hannover, Germany [email protected] Corresponding Author Received: 28.03.2021 Accepted after revision: 12.04.2021 Published online: 13.04.2021 DOI: 10.1055/a-1480-8983; Art ID: so-2021-d0018-spot License terms: © 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/) Abstract Key words azides, iodine azide, oxidation, polymer- bound reagents, radical reaction Vincent George studied chemistry at Leibniz University in Hannover (Germany) and received his master’s degree in chemistry in 2021 after While haloazides like iodine azide have been known for an Erasmus stay in Prague (Czech Republic), which was part of his mas- many years, their use in synthetic organic chemistry has ter’s studies on drugs and natural products. During his master’s thesis been considered challenging due to their unstable or even studies under the supervision of Prof. Dr. Andreas Kirschning, he ex- explosive nature.1 Due to the extraordinary versatility of plored new reaction conditions for the safe generation of bromine azide with versatile applications in radical reactions. these interhalogen reagents for synthetic chemistry, there is a fundamental demand for safe and easy-to-use substi- Andreas Kirschning studied chemistry at the University of Hamburg tutes. and at Southampton University (UK). In Hamburg, he joined the group of Prof. Ernst Schaumann and received his PhD in 1989. After a post- Although IN can be generated in situ from iodine chlo- 3 doctoral stay at the University of Washington (Seattle, USA) with Prof. 2 ride and sodium azide in polar solvents, this method and Heinz G. Floss, he started his independent research at Clausthal Univer- 3 4 similar routes from TlN3 or Bu3SnN3 have not gained wide sity of Technology in 1991, where he finished his habilitation in 1996. In 2000 he moved to the Leibniz University Hannover. His research inter- acceptance. A safe route for the formation of IN3 in the form of a stable analogue, the bisazidiodate(I) complexes 3 or 3′, ests cover structure elucidation as well as the semi-, muta- and total synthesis of natural products, complemented with the use of terpene which can be generated from organic iodide sources such as synthases as synthetic tools. Other important aspects of his research tetraalkylammonium iodide 1′ or basic ion-exchange resin deal with drug targeting and release and the development of synthetic in the iodide form 1.5–10 The first step represents the oxida- technologies (solid-phase-assisted synthesis, microreactors, and induc- tion of iodide, mediated by iodine(III) reagents, and the re- tive heating). Recently, he initiated a research program on the role of sulting iodate(I) complexes 2 or 2′ are then subjected to a coenzymes and cofactors being involved in the origin of life. ligand exchange reaction with Me3SiN3 to form the bis- azidoiodate(I) complexes 3 or 3′ (Scheme 1).11 While the used to recover the iodide loaded exchange resin 1 from ammonium-bound complex must be prepared in situ, a where polymer-bound reagent 3 can be regenerated.1,2 polymer-assisted version can be prepared on a large scale It has been suggested that iodine azide is released into and stored for several months under argon atmosphere at solution from the polymer-bound bisazido iodate(I) com- –15 °C without loss of activity. The polymer12 did not ex- plex 1 into the organic solvent of choice. There it can under- hibit explosive properties in impact experiments. Reactions go a variety of reactions under well-controlled conditions. with these functionalized polymers can be terminated by With alkenes, 1,2-addition is usually observed, yielding the simple filtration. Active reagents remaining in solution can corresponding 2-iodoazides. Noteworthy, these reactions subsequently be removed by workup with thiosulfate-load- tolerate various other functional groups and, in combina- ed ion-exchange resin 5, eliminating the need for aqueous tions with other functionalized polymers such as polymer- workup. Filtered polymeric byproducts such as 4 can be bound 1,8-diazabicyclo (5.4.0)undec-7-ene (DBU) 6, could © 2021. The Author(s). SynOpen 2021, 5, 104–107 Georg Thieme Verlag KG, Rüdigerstraße 14, 70469 Stuttgart, Germany 105 SynOpen V. George, A. Kirschning Spotlight tion products. Problems arising from the photoinstability of the carbo–iodine bond formed can be circumvented by ad- dition of a stable radical scavenger such as (2,2,6,6-tetra- methylpiperidin-1-yl)oxyl (TEMPO). This results in azido- oxygenated products from alkenes. In contrast, sterically very demanding substrates are oxidatively converted into bisazido adducts (Table 1, B). In this way, iodine azide can not only be added to dou- ble bonds, but the photochemically generated azide radical can abstract hydrogen atoms from secondary alcohols to Scheme 1 Preparation of iodate(I)-based IN3 analogue 3 and regenera- form intermediate ketyl radicals. The second H-abstraction tion from byproduct 4 via 1; ion-exchange resin 5 suitable for reductive then terminates the oxidation of the secondary alcohol and workup of reactions with 3 (R = polystyrene 1, 2, 3 or alkyl 1′, 2′, 3′). ketones are formed. The chemoselectivity of this oxidation The photograph of 3 displays the orange color of the resin. is particularly noteworthy because it leaves primary alco- hols unaffected (Table 1, C). be used as chemically active fixed-bed materials inside flow Under forcing conditions, however, primary alcohols reactors (Table 1, A). also react, presumably to form aldehydes, which then un- If these reaction mixtures are irradiated with light, e.g., dergo further H-abstraction under the photochemical con- using blue LEDs, a drastically changed reactivity is ob- ditions, and in that case the acyl radical is scavenged by the served. Iodine azide is then no longer characterized by the N3 radical and acyl azides are formed, which further rear- electrophilicity of iodine, but radicals now dominate the re- range to the carbamoyl azide by Curtius rearrangement (Ta- action events. This includes the formation of radical addi- ble 1, D). 13 Table 1 Applications of Polymer-Bound Bisazidoiodate(I) Complex 3 and a Stable Form of IN3 (A) The addition of 313 to alkenes will result in electrophilic addition, forming N the 1,2-anti-iodoazidated product. A large variety of functional groups, such 3 as alcohols, nitro groups, and pyridines, is tolerated.2 The conditions can even NMe3 I N be used to functionalize glycals with good yields, giving glycosyl azides.3 Fur- 3 N 3 (5 eq.), 3 ther treatment with non-nucleophilic bases such as DBU can induce the elimi- CH2Cl2, 20 h nation of hydrogen iodide towards the newly introduced azide group. This was I 78% reported for a telescoped flow protocol.4,5 TESO OTBS TESO OTBS 3 (4 eq.), CH2Cl2, 12 h O O TESO N3 TESO 82% I β-galacto/α-talo = 9:1 3 (8 eq.), N3 CH Cl , 2 d Ph 2 2 Ph I 48% H H Flow protocol: N3 NMe3 I DBU N3 N3 OH 3 6 Ph Ph CH2Cl2, 0.03 mL/min 91% OH 13 (B) The addition of iodate(I) complex 3 to alkenes under irradiation condi- O-TEMP tions using blue LEDs results in the formation of the 1,2-bisazido addition 3, TEMPO, blue LED, CH2Cl2, 20 h product. However, the intermediate C-radical formed can be trapped with N3 TEMPO to furnish the anti-azido-oxygenated product.1 Sterically demanding 77% alkenes preferentially still furnish 1,2-bisazides under these conditions. But: O O 3, TEMPO, blue LED, H CH2Cl2, 20 h H H H 50% H H AcO AcO N3 N3 SynOpen 2021, 5, 104–107 106 SynOpen V. George, A. Kirschning Spotlight (C) Ion-exchange resin 3 can also be used to oxidize secondary alcohols in the OH OH 1,13 3 (4 eq.), MeCN, presence of primary ones with good yields and high selectivity. blue LED, rt, 20 h 88% OH O (D) In the absence of secondary alcohols, primary alcohols can be oxidized un- OH 3 (4 eq.), MeCN, H der forcing conditions with blue LED irradiation forming the carbamoyl azide. N N3 blue LED, rt, 18 h C H The reaction is proposed to proceed via ketyl radicals and acyl azides that un- 5 11 C6H13 82% O dergo Curtius rearrangement. Consequently, aldehydes are converted into the corresponding acyl azides. However, if the mixture is heated instead of being O 3 (4 eq.), MeCN, O exposed to irradiation, the Curtius rearrangement takes place forming the blue LED, rt, 18 h carbamoyl azide.1,6,7,13 C6H13 H 90% C6H13 N3 3 (5 eq.), MeCN, H O N N 83 °C, 4 h 3 C6H13 C7H15 H 87% O (E) Oxidation and trisazidation of para-substituted phenol derivatives are O O achieved with polymer 3.8,13 Exposure of phenol to 3 results in 2,4,6- 3 (5 eq.), triiodophenol (not shown). H MeCN, 2 h N3 H N3 H H 92% H H HO O N3 13 (F) Ion exchange resin 3 promotes the double -functionalization of O O ketones.8 Secondary -positions will undergo monoazidation.
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