Estudos

http://aformulabr.com.br/qrcode/venetendrocafv01.pdf

VENETRON® Fitoterapia multifuncional

DESCRIÇÃO

Venetron® é um arbusto extraído da planta Apocynum venetum L que cresce exclusivamente do noroeste da China, sendo conhecido como Luobuma na cultura da China.

MECANISMO DE AÇÃO

Venetron® (Apocynum venetum L) possui efeito sobre a função cerebral com base em flavonoides, sendo eficaz na melhora do sono, ansiedade e irritabilidade. Além disso, estudos apontam que a Apocynum venetum L presente no Venetron® aumenta as concentrações de serotonina, auxiliando na melhora do humor e ansiedade. Dessa forma,o Venetron® é uma outra opção ao tratamento da , sem causar os efeitos colaterais indesejáveis ocasionados com os antidepressivos.

INDICAÇÕES

 Antidepressivo;  Regulador do sono;  Hepaprotetor.

DOSE USUAL

Recomendação oral de 25mg a 50mg de Venetron® (Apocynum venetum L) ao dia.

SUGESTÕES DE FÓRMULAS

Venetron® (Apocynum venetum L) ...... 25mg Venetron® (Apocynum venetum L) ...... 25mg Griffonia simplicifolia...... 50mg Modo de uso: 1 dose, 2 vezes ao dia. Mulungu (Erythrina mulungu) ...... 80mg Indicação: antidepressivo. Modo de uso: 1 dose a noite.

Indicação: regulador do sono.

PRINCIPAIS REFERÊNCIAS

YAMATSU, Atsushi et al. The improvement of sleep by oral intake of GABA and Apocynum venetum leaf extract. Journal of nutritional science and vitaminology, v. 61, n. 2, p. 182-187, 2015. Disponível em < https://www.ncbi.nlm.nih.gov/pubmed/26052150>Acesso em :27 de Fevereiro de 2019.

XIE, Wenyan et al. Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L.(Luobuma): A review. Journal of ethnopharmacology, v. 141, n. 1, p. 1-8, 2012. Disponível em < https://www.ncbi.nlm.nih.gov/pubmed/22421379>Acesso em :27 de Fevereiro de 2019.

VENETRON® Estudos clínicos

The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract.

AbstractThe effects of two food materials, γ-aminobutyric acid (GABA) produced by natural fermentation and Apocynum venetum leaf extract (AVLE), on the improvement of sleep were investigated in humans. The electroencephalogram (EEG) test revealed that oral administration of GABA (100 mg) and AVLE (50 mg) had beneficial effects on sleep. GABA shortened sleep latency by 5.3 min and AVLE increased non-rapid eye movement (REM) sleep time by 7.6%. Simultaneous intake of GABA and AVLE shortened sleep latency by 4.3 min and increased non-REM sleep time by 5.1%. The result of questionnaires showed that GABA and AVLE enabled subjects to realize the effects on sleep. These results mean that GABA can help people to fall asleep quickly, AVLE induces deep sleep, and they function complementarily with simultaneous intake. Since both GABA and AVLE are materials of foods and have been ingested for a long time, they can be regarded as safe and appropriate for daily intake in order to improve the quality of sleep.

Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L. (Luobuma): A review..

Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Apocynum venetum L. (Apocynaceae, Luobuma ) has a long history as a Chinese traditional medicine with uses to calm the liver, soothe the nerves, dissipate heat, and promote diuresis. Recently, Luobuma tea has been commercialized as a sedative and anti-aging supplement that has become increasingly popular in North American and East Asian health food markets. AIMS OF THE REVIEW: The aim of this review is to provide an up-to-date and comprehensive overview of the botany, chemical constituents, traditional uses, pharmacological activities and safety aspects of Apocynum venetum in order to assess its ethnopharmacological use and to explore its therapeutic potentials and future opportunities for research. BACKGROUND AND METHODS: The accessible literature on Apocynum venetum written in English, Chinese and Japanese were collected and analyzed. The literatures included ancient Chinese herbal classics, pharmacopoeias and articles that included in Pubmed, Web of Science, Google Scholar and Wanfang. KEY FINDINGS: Modern pharmacological studies demonstrated that Apocynum venetum possess wide pharmacological activities that include antihypertensive, cardiotonic, hepatoprotective, antioxidant, lipid-lowering, antidepressant and anxiolytic effects, which can be explained by the presence of various flavonoid compounds in this plant. The traditional (Lop Nor region) use of Apocynum venetum with tobacco as an agent to detoxify nicotine may receive interest as a possible therapeutic option to detoxify the body from smoking. Based on animal studies and clinical trials, Apocynum venetum causes no severe side effects, even in a stable daily dosage (50mg/person/day) for more than three years. CONCLUSIONS: Apocynum venetum potentially has therapeutic potential in the prevention and treatment for the cardiovascular and neurological diseases, especially for high blood pressure, high cholesterol, neurasthenia, depression and anxiety. Further investigations are needed to explore individual bioact

Antidepressant-like effect of flavonoids extracted from Apocynum venetum leaves on brain monoamine levels and dopaminergic system.

Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Apocynum venetum L. (Apocynaceae), a traditional medicinal plant, has been used for the improvement of emotions in Asian countries. AIM OF THE STUDY: We explored the antidepressant-like effect and monoaminergic mechanism of a flavonoids extract from Apocynum venetum leaves (AV-extract). MATERIALS AND METHODS: Effect of AV-extract (25, 50 and 100 mg/kg, i.g.) on mice's immobility time was assessed in forced swim test (FST) and tail suspension test (TST). The locomotor activity was evaluated in the open-field test (OFT). Additionally, the main monoamine neurotransmitters serotonin (5-HT), noradrenaline (NA) and dopamine (DA) and their metabolites 5-hydroxyindole-3-acetic acid (5-HIAA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the mouse hippocampus involved in the antidepressant-like effect of AV- extract was also determined by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI- MS-MS). RESULTS: AV-extract (50 and 100 mg/kg, i.g.) administration significantly reduced the immobility time in both the FST and TST without accompanying changes in locomotor activity in the OFT. It was also found that the AV- extract significantly increased the concentrations of the main neurotransmitters NE and DA along with their respective metabolites DOPAC, HVA in the hippocampus. The antidepressant-like effect of the AV-extract (50 mg/kg, i.g.) was prevented by the pretreatment of mice with SCH23390 (0.05 mg/kg, i.g., a dopamine D1 receptor antagonist) or sulpiride (50 mg/kg, i.g., a dopamine D2 receptor antagonist). CONCLUSION: The AV-extract produced significant antidepressant-like effects, which likely attribute to increased NE and DA along with their respective metabolites DOPAC, HVA in the mouse hippocampus, and dependent on interaction with dopaminergic (D1 and D2 receptor) systems.

REFERÊNCIAS

YAMATSU, Atsushi et al. The improvement of sleep by oral intake of GABA and Apocynum venetum leaf extract. Journal of nutritional science and vitaminology, v. 61, n. 2, p. 182-187, 2015.Disponivel em < https://www.ncbi.nlm.nih.gov/pubmed/26052150>Acesso em :27 de Fevereiro de 2019.

XIE, Wenyan et al. Botany, traditional uses, phytochemistry and pharmacology of Apocynum venetum L.(Luobuma): A review. Journal of ethnopharmacology, v. 141, n. 1, p. 1-8, 2012.Disponivel em < https://www.ncbi.nlm.nih.gov/pubmed/22421379>Acesso em :27 de Fevereiro de 2019.

ZHENG, Meizhu et al. Antidepressant-like effect of flavonoids extracted from Apocynum venetum leaves on brain monoamine levels and dopaminergic system. Journal of ethnopharmacology, v. 147, n. 1, p. 108-113, 2013.Disponivel em < https://www.ncbi.nlm.nih.gov/pubmed/23453939>Acesso em: 27 de Fevereiro de 2019.