Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000686005Cyc: Phyllobacterium sp. UNC302MFCol5.2 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

lipid II (meso diaminopimelate 3-O-L-lysyl-1-O- containing) phosphate phosphatidylglycerol

FtsW RS0112300 MprF

lipid II (meso 3-O-L-lysyl-1-O- diaminopimelate phosphatidylglycerol containing) phosphate

Amino Acid Degradation Storage Compound Biosynthesis Polyprenyl Biosynthesis Hormone Biosynthesis Aromatic Compound Biosynthesis Macromolecule Modification tRNA-uridine 2-thiolation ATP N 6 -(3-methylbut- ditrans,octacis- ditrans,octacis- a 1-acyl-2- a [DNA]-3'- a 5'-phospho- a [protein]-L- and selenation (bacteria) an L-cysteinyl- 34 di-trans,poly-cis indole-3-acetate biosynthesis L-valine degradation I a sulfurated adenosylcobinamide a purine a [glutamine- an L-asparaginyl- a cytidine polyhydroxybutanoate biosynthesis chorismate biosynthesis I L-leucine degradation I L-arginine degradation V L-histidine degradation II L-tryptophan degradation to 2-en-1-yl)- undecaprenyldiphospho- undecaprenyldiphospho- arachidonoyl- hydroxyl [DNA] Asn Cys lys methionine L-tyrosine degradation I ATP [tRNA ] [tRNA ] ATP roseoflavin Ile2 Metabolic Regulator Biosynthesis -undecaprenyl biosynthesis 3-(4-hydroxyphenyl) Alcohol Degradation [sulfur carrier] 37 ribonucleoside synthetase]- in tRNA peptide- (arginine deiminase pathway) 2-amino-3-carboxymuconate adenosine N-acetyl-(N- N-acetyl-(N- sn-glycerol 5'-phosphate Aminoacyl-tRNA Charging glutaminyl-tRNA gln biosynthesis via transamidation phosphate biosynthesis IV (bacteria) D-erythrose pyruvate biosynthesis cys in tRNA 5'-triphosphate acetylglucosaminyl) acetylglucosaminyl) 3-phosphate CTP L-tyrosine methionine acetyl-CoA ADP val semialdehyde ATP-dependent ppGpp metabolism (2E,6E)-farnesyl (indol-3-yl) 4-phosphate leu tyr his glycerol and glycerophosphodiester degradation muramoyl-L-alanyl-γ- muramoyl-L-alanyl- (S)-S-oxide glycine betaine IPP 3-deoxy-7- cysteine ATP synthase arg aminoacyl-tRNA aminoacyl-tRNA tRNA diphosphate acetonitrile histidine trp tRNA (N6-isopentenyl bifunctional β γ DNA ligase: bifunctional reductase acetyl-CoA C- nitrile phosphoheptulonate tyr branched-chain branched-chain bifunctional D-isoglutaminyl-N-( - -D-isoglutaminyl- phosphatidate bifunctional [glutamine hydrolase: hydrolase: lysidine(34) glu biosynthesis I (Gram- desulfurase: subunit C: adenosine(37)-C2)- adenosylcobinamide BR48_RS0114820 MsrA: msrA pppGpp acetyltransferase: hydratase: bifunctional amino acid aspartate arginine ammonia- tryptophan 2,3- glycerol D-asparaginyl)-L-lysyl- N-(β-D-asparaginyl) synthetase] BR48_RS0122835 BR48_RS0122835 riboflavin kinase/ synthetase negative bacteria) synthase class II: sufS BR48_RS25055 amino acid methylthiotransferase kinase/ cytidylyltransferase: BR48_RS0105330 isoprenyl nthB nthA aspartate aminotransferase: transaminase/ deiminase: lyase: hutH dioxygenase: D-alanyl-D-alanine -L-lysyl-D-alanine adenylyltransferase/ cisplatin damage FAD synthetase: TilS: tilS peptide- (indol-3-yl) 3-deoxy- BR48_RS0113025 cysteine desulfurase: [+ 7 isozymes] aminotransferase: urocanate MiaB: miaB adenosylcobinamide- BR48_RS0118130 aminoacyl-tRNA aminoacyl-tRNA choline [+ 2 isozymes] transferase: transaminase/ BR48_RS0122710 aspartate 4- arcA kynA L-proline degradation I [glutamine synthetase]- response ATP- BR48_RS0104475 methionine D-arabino- ATP BR48_RS0122710 N-Formyl-L- phosphate phosphatidate hydrolase: hydrolase: bifunctional (p)ppGpp choline acetamide BR48_RS0111395 succinate adenylyl-L-tyrosine dependent BR48_RS0118125 aspartate 4- decarboxylase: urocanate kynurenine a glycerophosphodiester 34 (S)-S-oxide dehydrogenase: heptulosonate an [L-cysteine branched-chain branched-chain guanylyltransferase: monofunctional monofunctional cytidylyltransferase: BR48_RS0108530 BR48_RS0108530 a lysidine synthetase/guanosine- acetoacetyl-CoA amidase: decarboxylase: BR48_RS0118820 L-citrulline dehydrogenase, phosphorylase: DNA ligase: roseoflavin reductase an L-glutamyl- 7-phosphate desulfurase]-S- amino acid amino acid hydratase: pro glycerol cobU biosynthetic biosynthetic BR48_RS0110235 in tRNA Ile2 3',5'-bis(diphosphate) 3'- betA di-trans,octa-cis BR48_RS0115470 BR48_RS0118820 hydrophobic BR48_RS0102920 BR48_RS0116220 adenine MsrA: msrA [tRNA Gln ] 3-dehydroquinate sulfanyl-L-cysteine aminotransferase: aminotransferase: bifunctional BR48_RS0106840 peptidoglycan peptidoglycan a protein-L- pyrophosphohydrolase: betaine aldehyde -undecaprenyl [+ 2 isozymes] bifunctional glycerophosphodiester membrane anchor adenosyl- dinucleotide synthase: bifunctional BR48_RS0103245 4-methyl-2-BR48_RS0103245 aspartate 4-imidazolone- transglycosylase: transglycosylase: tRNA Asn a tRNA Cys Asp-tRNA(Asn) BR48_RS0102465 diphosphate ornithine proline glycerol kinase phosphodiesterase: protein: sdhD cobinamide a CDP-1-acyl- asn cys methionine- betaine-aldehyde aspartate 5-propanoate mtgA mtgA a [glutamine /Glu-tRNA(Gln) (3R)-3- undecaprenyl- (indol-3-yl)acetate BR48_RS0110835 3-methyl-2- oxopentanoate transaminase/ carbamoyltransferase: L-kynurenine dehydrogenase/L- GlpK: glpK BR48_RS0118090 phosphate a purine 2-arachidonoyl- [DNA] (S)-S-oxide dehydrogenase: transaminase/ 6 synthetase]-O gln amidotransferase hydroxybutanoyl- poly-[(R)-3- diphosphate a [TusA sulfur- oxobutanoate aspartate 4- argF imidazolonepropionase: glutamate gamma- N -(3-methylbut- ribonucleoside glycerol betB 3-dehydroquinate aspartate 4- 5'-deoxyadenosine an unsulfurated 4 -(5'-adenylyl) subunit GatB: gatB CoA hydroxybutanoate] phosphatase: carrier protein]-S- decarboxylase: BR48_RS0106825 semialdehyde 2-en-1-yl)-2- met 5'-diphosphate a peptidoglycan di-trans,octa-cis a peptidoglycan di-trans,octa-cis GTP ppGpp 3-(4- [sulfur carrier] -L-tyrosine Asp-tRNA(Asn) decarboxylase: sulfanyl-L-cysteine BR48_RS0112475 sn-glycerol 3-phosphate (methylsulfanyl) dimer (E. faeciums) -undecaprenyl dimer (E. faecium -undecaprenyl Asp-tRNA(Asn) glycine betaine BR48_RS0108145 type II 3- carbamoyl dehydrogenase 3-(4- BR48_RS0112475 3-methylbutanoyl- hydroxyphenyl) N-formimino- 37 /Glu-tRNA(Gln) class I poly(R)- di-trans,octa-cis dehydroquinate L-ornithine PutA: putA adenosine diphosphate , tetrapeptide) diphosphate /Glu-tRNA(Gln) hydroxyphenyl) CoA pyruvate phosphate L-glutamate (S)-1-pyrroline- glycerol-3-phosphate amidotransferase nucleoside- bifunctional (p)ppGpp hydroxyalkanoic -undecaprenyl dehydratase: aroQ isobutanoyl-CoA 3-hydroxy- in tRNA amidotransferase: pyruvate isovaleryl-CoA glutamine- 5-carboxylate dehydrogenase: subunit GatB: gatB diphosphate kinase: synthetase/guanosine- acid synthase: phosphate 4-hydroxyphenylpyruvate formimidoylglutamate L-kynurenine gatC gatA a [TusD sulfur- BR48_RS0107715 [+ 7 isozymes] phaC 3-dehydroshikimate dehydrogenase: dioxygenase: hppD hydrolyzing deiminase: F0F1 ATP a 5-phosphooxy- BR48_RS0102030 3',5'-bis(diphosphate) 3'- + + carrier protein]-S- BR48_RS0102795 carbamoyl- kynureninase: ditrans,octacis- a peptidoglycan with an [HPr]- phosphoenol a carboxy- a mature a [glutamine 4-methyl-5-(2- L-rhamnulose succinate (E)-4-hydroxy-3- a protein-L- H H pyrophosphohydrolase: BR48_RS0106820 menadione NADH H + synthase ammonium L-glutamyl- shikimate sulfanyl-L-cysteine kynU DHAP undecaprenyldiphospho- (L-alanyl-γ-D-glutamyl- adenylated- cys peptidoglycan synthetase]-O phosphooxyethyl) 1-phosphate methylbut-2-en- methionine- poly-[(R)-3- 3-methylcrotonyl- homogentisate phosphate L-histidine pyruvate (n) HMP-PP semialdehyde ATP [tRNA Gln ] BR48_RS0102465 dehydrogenase: N-formyl- β 4 thiazole 1-yl diphosphate synthase: L-glutamate-5- N-acetyl-(N-acetyl- -D- L-lysyl-D-alanyl-D- [ThiS sulfur- (meso-DAP -(5'-adenylyl) NAD-dependent biotin flavodoxin- (R)-S-oxide hydroxybutanoate] methylacrylyl-CoA CoA 3-hydroxyanthranilate peptide- BR48_RS0108640 homogentisate carA carB L-glutamate semialdehyde Aromatic Compound glucosaminyl)muramoyl- alanine) pentapeptide carrier protein] containing) -L-tyrosine succinate- a reduced Asp-tRNA(Asn) methylcrotonoyl- phosphoenolpyruvate- bifunctional dependent methionine a [TusE sulfur enoyl-CoA 1,2-dioxygenase: N-formylglutamate Degradation L-alanyl-γ-D-glutamyl-L- NADH-quinone semialdehyde H O c-type thiamine (E)-4-hydroxy- (R)-S-oxide 2 /Glu-tRNA(Gln) GDP shikimate CoA carboxylase: BR48_RS0116270 carbamate bifunctional lysyl-D-alanyl-D-alanine -protein oxidoreductase: rhamnulose-1- dehydrogenase: biotin--[acetyl-CoA- 34 carrier protein]-S hydratase: amidohydrolase: lytic phosphate 3-methylbut- cytochrome amidotransferase a uridine in tRNA BR48_RS0102800 proline 4-hydroxyphenylacetate phosphotransferase: ptsP cysteine desulfurase: BR48_RS0117355 bifunctional [glutamine phosphate aldolase/ reductase RS0119895 an oxidized -sulfanylcysteine BR48_RS0117195 4-maleyl- BR48_RS0110080 synthase: BR48_RS0116570 carboxylase] ligase: subunit GatB: gatB shikimate kinase: [+ 2 isozymes] dehydrogenase/L- degradation BR48_RS0111395 transglycosylase synthetase] short-chain 2-enyl- MsrB: msrB O c-type acetoacetate 2-amino-3- phosphoenolpyruvate- BR48_RS0117360 BR48_RS0117420 2 BR48_RS24335 enoyl-CoA L-glutamate [+ 3 isozymes] glutamate gamma- monofunctional cysteine F: BR48_RS24500 adenylyltransferase/ thiE dehydrogenase: NAD-dependent diphosphate cytochromea reduced Asp-tRNA(Asn) tRNA 2- 3-methylglutaconyl- carboxymuconate- -protein BR48_RS0117365 peptide- hydratase: maleylacetoacetate degradation VI (4-hydroxyphenyl) biosynthetic desulfurase: [+ 8 isozymes] [glutamine synthetase]- thiamine phosphate succinate- synthase: ispG H O c-type CoA 6-semialdehyde semialdehyde phosphotransferase: ptsP BR48_RS0117380 BR48_RS0121205 2-C-methyl-D- methionine 2 /Glu-tRNA(Gln) shikimate 3- thiouridine(34) (to pyruvate) glu acetate peptidoglycan semialdehyde BR48_RS0105860 isomerase: maiA CO dehydrogenase 4-hydroxyphenylacetate sufS nuoH nuoI adenylyl-L-tyrosine synthase: biotinyl-5'- erythritol-2,4- (R)-S-oxide RS0119890 ancytochrome oxidized amidotransferase: phosphate synthase 2 transglycosylase: phosphorylase: dehydrogenase: (S)-3-hydroxy- 4-fumaryl- PutA: putA 3-monooxygenase: BR48_RS0117395 a mature GlcNAc-1,6- BR48_RS0110425 adenylate cyclodiphosphate reductase O c-type gatC gatA 3-phosphoshikimate 1- MnmA: mnmA glu an [HPr protein]- BR48_RS0113300 2 isobutanoyl-CoA BR48_RS0112605 mtgA π peptidoglycan anhMurNAc- BR48_RS0102920 DHAP (S)-lactaldehyde a reduced acetoacetate (3,4-dihydroxyphenyl) N -phospho- pyruvate a thiocarboxylated- nuoK (n) MsrB: msrB cytochrome carboxyvinyltransferase: glu γ a [protein]-L- 34 L-arginine ala [ThiS sulfur- BR48_RS0117410 (meso-DAP L-Ala- -D-Glu- succinate H O c-type an L-glutaminyl- a 2-thiouridine HMG-CoA acetate L-histidine AMP thiamine 2 aroA a peptidoglycan with di-trans,octa-cis containing) DAP-D-Ala a [glutamine- methionine cytochrome Gln in tRNA degradation VI carrier protein] nuoN phosphate CtaD an oxidized [tRNA ] tRNA charging 3-phosphoshikimate 1- γ -undecaprenyl synthetase]- (arginase 2 pathway) (L-alanyl- -D-glutamyl- ADP O c-type carboxyvinyltransferase: tRNA uridine-5- (S)-3-hydroxy- diphosphate 2 fumarate (2S, 3S)-3- L-lysyl-D-alanyl-D- L-tyrosine cytochromea reduced aroA carboxymethylaminomethyl(34) isobutanoate arg 2-hydroxy-5- methylaspartate alanine) pentapeptide NAD + menadiol H O c-type glu a tRNA glu 5-enolpyruvoyl- synthesis GTPase MnmE: mnmE 3-hydroxyisobutyrate carboxymethylmuconate 2 acetoacetate arginase: glycine cleavage RS0119880 cytochrome gly Gly phe Phe shikimate 3- dehydrogenase: semialdehyde an oxidized a tRNA a tRNA tRNA uridine-5- rocF Cys Ile His Lys Trp Leu Tyr Arg Val Ala asp Pro Thr Met Met phosphate a [glycine-cleavage O c-type cys a tRNA ile a tRNA his a tRNA lys a tRNA trp a tRNA leu a tRNA tyr a tRNA arg a tRNA val a tRNA a tRNA ala tRNA asp pro a tRNA thr a tRNA elongator tRNA met initiator tRNA met carboxymethylaminomethyl(34) mmsB 2 ser ser asn Asn gln Gln L-ornithine complex H protein] N 6 a ring-opened 7- ditrans,octacis- a [protein]-L- an N-terminal- a peptide with an [amino-group acytochrome reduced a tRNA glutamate--tRNA ligase: tRNA a tRNA chorismate synthesis enzyme MnmG: mnmG (S)-methylmalonate- L-methionine degradation glycine a single 3'-dephospho- an (R)-2- an N-modified -[(R)-lipoyl]-L-lysine methylguanine undecaprenyldiphospho- a tRNA precursor asp β-isoaspartate L-methionyl-L- an N-terminal carrier protein]- H O c-type BR48_RS0118175 glycine--tRNA ligase: phenylalanine- synthase: semialdehyde I (to L-homocysteine) mesaconate stranded DNA ATP CoA halocarboxylate aminoacyl-[tRNA] 2 a 5-carboxymethylaminomethyl- ornithine--oxo-acid cleavage 5-carboxymethyl-2- in DNA protein-L- valyl-[protein] L-methionine C-terminal-γ- cytochrome cysteine--tRNA ligase: isoleucine--tRNA ligase: histidine--tRNA ligase: lysine--tRNA ligase: tryptophan-- leucine--tRNA ligase: tyrosine--tRNA ligase: arginine--tRNA ligase: valine--tRNA ligase: alanine--tRNA aspartate--tRNA proline--tRNA ligase: threonine--tRNA glutamate--tRNA ligase: methionine--tRNA ligase: methionine--tRNA ligase: BR48_RS0103905 -tRNA ligase: aroC 34 aminomethyl- N-acetyl-(N- bifunctional aspartate RS0119900 an oxidized 2-thiouridine in tRNA transaminase: system hydroxymuconate isoaspartate O- BR48_RS0102265 BR48_RS0104460 BR48_RS0104565 BR48_RS0105305 tRNA ligase: trpS BR48_RS0109430 BR48_RS0111410 serine--tRNA ligase: serS BR48_RS0111790 BR48_RS0111830 ligase: alaS ligase: aspS BR48_RS0117460 ligase: thrS BR48_RS0112985 BR48_RS0122025 BR48_RS0122025 BR48_RS0103915 BR48_RS0108385 pheS transferring acetylglucosaminyl) transaminase/aspartate (L-glutamate 5- O c-type met BR48_RS0117970 protein exodeoxyribonuclease HAD family methyltransferase: N-acetyl- 2 chorismate glycine bifunctional DNA- muramoyl-L-alanyl-γ-D- aminoacyl-tRNA ribonuclease D: 4-decarboxylase: type I methionyl type I methionyl semialdehyde-2- acytochrome reduced protein S-nitrosylation methionine GcvH: gcvH VII large subunit: hydrolase: BR48_RS0111845 gamma- L-glutamate-5- dehydrogenase: formamidopyrimidine triphosphoribosyl- isoglutaminyl-L-lysyl- hydrolase: BR48_RS0107085 BR48_RS0118820 aminopeptidase: aminopeptidase: yl)-L-glutamate H O c-type and denitrosylation adenosyltransferase: BR48_RS0104685 BR48_RS0107105 2 cytochrome an L-cysteinyl-[tRNA Cys ] an L-isoleucyl-[tRNA Ile ] an L-histidyl-[tRNA His ] an L-lysyl-[tRNA Lys ] an L-tryptophanyl-[tRNA Trp ] an L-leucyl-[tRNA Leu ] an L-tyrosyl-[tRNA Tyr ] an L-seryl-[tRNA ser ] an L-arginyl-[tRNA Arg ] an L-valyl-[tRNA Val ] an L-alanyl-[tRNA Ala ] an L-aspartyl-[tRNA asp ] an L-prolyl-[tRNA Pro ] an L-threonyl-[tRNA Thr ] an L-glutamyl-[tRNA Glu ] an L-methionyl-[elongator tRNA Met ] an L-methionyl-[initiator tRNA Met ] a glycyl-[tRNA Gly ] an L-phenylalanyl-[tRNA Phe ] an L-asparaginyl-[tRNA Asn ] an L-glutaminyl-[tRNA Gln ] (S)-3-amino-2- (S)-citramalate [+ 2 isozymes] dephospho- (glycyl) -D-alanyl-D-alanine protein-L- map map glutamyl- cytochrome a 5-aminomethyl-2- hydrogencarbonate semialdehyde gcvP glycosylase/ 5 BR48_RS0122835 ribonuclease BR48_RS0106110 (3E,5R)-5-carboxy-2- exodeoxyribonuclease HAD family bifunctional aspartate c oxidase an oxidized 34 a [protein]- methylpropanoate a [glycine-cleavage CoA synthase: isoaspartate(D- phosphate thiouridine in tRNA [+ 5 isozymes]a [glycine-cleavage oxohept-3-enedioate DNA-(apurinic aminoacyl-tRNA D: rnd transaminase/aspartate an [amino-group O c-type SAM 6 VII small subunit: BR48_RS0119655 hydrolase: reductase: 2 L-cysteine 6 complex H protein] N - or apyrimidinic aspartate) O- a reduced citramalate complex H protein] N BR48_RS0103765 monofunctional BR48_RS0107395 hydrolase: 4-decarboxylase: an N-terminal carrier protein]- cytochrome aminomethyldihydrolipoyl- site) lyase: mutM methyltransferase: argC H O c-type synthase: -dihydrolipoyl-L-lysine biosynthetic BR48_RS0108530 BR48_RS0112475 met L-valyl-[protein] met a peptide C-terminal-γ- 2 L-lysine 2'-(5''-triphospho- a nucleoside 5'- BR48_RS0111740 cytochrome BR48_RS0102250 (S)-1-pyrroline- peptidoglycan a tRNA ala a protein L-β- (5-phospho- RS0100095 an oxidized a 5-methylaminomethyl- L-tryptophan α-D-ribosyl)-3'- monophosphate a [protein] 3- 5-carboxylate (4Z)-2-oxohept- a [DNA]- 2,6-diamino-4- a ribonucleoside a single-stranded transglycosylase: a (2R)-2- 34 a 5'-phospho- adenine a halide anion isoaspartate L-glutamyl)- O c-type 2-thiouridine in tRNA degradation I dephospho-CoA an uncharged 2 nitrosothio- pyrroline-5- 4-enedioate nucleotide- hydroxy-5-(N-methyl) 4-oxo-2-pentenal 5'-monophosphate oligodeoxyribonucleotide mtgA hydroxy fatty acid an N-modified α-methyl ester L-glutamate cytochrome (via anthranilate) SAH acetate pyruvate [DNA] tRNA heme b CcmA heme b peptidoglycan biosynthesis I (meso-diaminopimelate containing) Cell Structure Biosynthesis L-alanine carboxylate aminomethyl- 3'-phosphate formamidopyrimidine amino acid Kdo transfer to lipid IV biosynthesis (P. putida) peptidoglycan maturation (meso-diaminopimelate containing) Fatty Acid and Lipid Biosynthesis A lipid IV biosynthesis (E. coli) trp reductase: transferring a peptidoglycan di-trans,octa-cis lipid IV I (E. coli) α A adenosylhomocysteinase: A UDP-N-acetyl- -D-glucosamine a 5-methylaminomethyl- BR48_RS0104875 glycine dimer (S. aureus) -undecaprenyl a (3R)-3- lipid II (meso tryptophan 2,3- (4S)-4-hydroxy-2- 2+ 2+ a (3R)-3- palmitate biosynthesis (type II fatty acid synthase) 2-(S-geranyl) BR48_RS0108490 Cd CadA Cd UDP-N-acetylglucosamine hydroxydecanoyl- UDP-N-acetyl- dioxygenase: dehydrogenase: diphosphate CMP-Kdo lipid IV (E. coli) diaminopimelate containing) CDP-diacylglycerol 34 oxoheptanedioate A hydroxytetradecanoyl- UDP-N-acetyl- octanoyl-[acyl-carrier thiouridine in tRNA pro gcvP 1-carboxyvinyltransferase: [acp] α-D-glucosamine gondoate biosynthesis a [protein]- kynA L-serine degradation L-arginine [acp] α-D-glucosamine monofunctional protein] biosynthesis biosynthesis I S-nitrosoglutathione N-Formyl-L- L-homocysteine 2,4-dihydroxyhept- murA (anaerobic) L-cysteine degradation [+ 2 isozymes] a 7,8-dihydro- an [apo BCAA DNA with adenine:7,8- a [protein] N- queuosine at an N-terminal- 3-deoxy-D-manno- biosynthetic an acetoacetyl-[acp] (mitochondria, yeast) kynurenine L-threonine 2-ene-1,7-dioic quinoxaline-2- 7,8-dihydrofolate + acyl-ACP--UDP-N- S-(hydroxymethyl) 8-oxoguanine NADPH H + NADPH NAD dihydro-8- an L-aspartyl- L-methionyl- NADH L-canavanine α acyl-ACP--UDP-N- peptidoglycan DHAP III (arginine degradation II aryl-carrier protein carboxyl adenylate monoglutamate dehydrogenase terminal-formyl- Asn glu position 34 octulosonic acid UDP-N-acetyl- -D-glucosamine-enolpyruvate acetylglucosamine O- ser acid aldolase: [tRNA ] an acetoacetyl-[acp] a 5-methylaminomethyl- glutathione in DNA (3S)-3-methyl-2- 6 oxoguanine mismatch of a tRNA Asp glycyl-[protein] transferase: acetylglucosamine O- transglycosylase: 3-oxoacyl-[acyl-carrier- a malonyl-[acp] an oleoyl-[acp] decarboxylase/ BR48_RS0115525 E2 protein] N L-methionine Asp-tRNA(Asn) UDP-N-acetylmuramate acyltransferase: lpxA 2-(Se-phospho) dehydrogenase/ threonine/serine oxopentanoate BR48_RS0104395 acyltransferase: lpxA mtgA protein] reductase: fabG 3-oxoacyl- agmatinase pathway) -lipoyl-L-lysine 34 dehydratase: thr 2,4-dihydroxyhept- dihydrofolate NAD(P)(+) /Glu-tRNA(Gln) NAD(+) dehydrogenase: murB [+ 2 isozymes] [acyl-carrier- sn-glycerol selenouridine in tRNA class III alcohol arg L-aspartate degradation I arginase: ala UDP-3-O-[(3R)-3- a nascent peptidoglycan BR48_RS0120320 L-threonine 3- 2-ene-1,7-dioic bifunctional DNA- acyl carrier protein: A/G-specific peptide deformylase: amidotransferase tRNA glutamyl- type I methionyl diphosphatase: α glu α protein] beta-ketoacyl-ACP dehydrogenase: L-kynurenine L-glutamine reductase: transhydrogenase -Kdo-(2->6)- UDP-N-acetyl- -D-muramate hydroxydecanoyl]- UDP-3-O-[(3R)-3- with (L-alanyl-γ-D-glutamyl- 3-phosphate formamidopyrimidine BR48_RS0113315 3-methyl-2- adenine BR48_RS0114510 subunit GatB: gatB Q(34) synthetase aminopeptidase: rocF synthase II: fabF degradation I [+ 2 isozymes] dehydrogenase: acid aldolase: BR48_RS0113900 (Re/Si-specific): nudC lipid IV (E. coli) α hydroxymyristoyl]-N- meso-2,6-diaminopimeloyl-D- a (3R)-3-hydroxybutanoyl-[acp] reductase: BR48_RS0106775 2-aminoprop- glycosylase: map A N-acetyl- -D- glycerol-3- BR48_RS0121130 asp BR48_RS0112645 glycosylase/ acyl carrier protein: oxobutanoate BR48_RS0100100 peptide deformylase: Asp-tRNA(Asn) GluQRS: glutamate racemase: UDP-N-acetylmuramate- acetyl-α-D-glucosamine fabG beta-ketoacyl-ACP a 5-methylaminomethyl- kynureninase: 2-enoate agmatine L-2-amino-3- dihydrofolate glucosamine alanyl-D-alanine) pentapeptide phosphate 1-O- S-(hydroxysulfenamide) DNA-(apurinic BR48_RS0102135 dehydrogenase (2- BR48_RS0100105 mutY BR48_RS0106190 /Glu-tRNA(Gln) BR48_RS0111070 reduced β- BR48_RS0112755 UDP-3-O-acyl-N- 3-hydroxyacyl-[acyl- synthase I: fabB 34 kynU gln oxobutanoate bifunctional aspartate reductase: -L-alanine ligase: UDP-3-O-acyl-N- [+ 2 isozymes] acyltransferase 2-selenouridine glutathione succinate semialdehyde or apyrimidinic methylpropanoyl- L-canaline urea acetylglucosamine carrier-protein] a (3R)-3- Asp-tRNA(Asn) agmatinase: transaminase/aspartate BR48_RS0114935 BR48_RS0100110 amidotransferase: an N-terminal nicotinamide D- α BR48_RS0114140 penicillin-binding PlsY: plsY in tRNA glycine C- site) lyase: mutM AMP -Kdo-(2->4)- acetylglucosamine hydroxybutanoyl-[acp] anthranilate speB a quinoxaline-2- transferring) an apurinic site gatC gatA glutamyl- met glycyl-[protein] ribonucleotide D-glt deacetylase: protein 2: dehydratase FabA: fabA a 1-acyl-sn /Glu-tRNA(Gln) acetyltransferase: 4-decarboxylase: succinate an N-terminal L- α-Kdo-(2->6)- deacetylase: carboxyl-[aryl- subunit alpha: within DNA formate an L-asparaginyl- queuosine at α BR48_RS0114100 3-hydroxyacyl- an (11Z)-3-oxo-icos-11-enoyl-[acp] amidotransferase agmatinase: BR48_RS0118820 semialdehyde AMP adenine methionyl-[protein] Asn UDP-N-acetyl- -D-muramoyl-L-alanine a nascent peptidoglycan BR48_RS0114175 a mature peptidoglycan with 3-hydroxyacyl-ACP -glycerol 3- 2-iminopropanoate BR48_RS0121135 5,6,7,8- + [tRNA ] lipid IV (E. coli) BR48_RS0114100 UDP-3-O-(3- a [DNA]- carrier protein] + BR48_RS0117780 NADH NADP position 34 A γ γ dehydratase FabZ: fabZ [acyl-carrier- phosphate subunit GatB: gatB speB bifunctional aspartate dehydrogenase a 5'-phospho- 7,8-dihydro- NADP UDP-3-O-(3- with (L-alanyl- -D-glutamyl- (L-alanyl- -D-glutamyl-meso- hydroxylamine 4-oxo-2-pentenal tetrahydrofolate Asp hydroxymyristoyl) beta-ketoacyl-ACP + nucleotide- [DNA] of a tRNA UDP-N-acetylmuramoyl- hydroxydecanoyl) meso-2,6-diaminopimeloyl- a nascent peptidoglycan 2,6-diaminopimeloyl-D-alanyl- protein] 1-acyl-sn-glycerol- tRNA processing [+ 7 isozymes] L-asparagine gly transaminase/aspartate (NADP ): 8-oxoguanine -α-D-glucosamine reductase: phbB putrescine L-phenylalanine 3'-phosphate an [apo BCAA dehydrogenase L-alanine--D-glutamate -α-D-glucosamine D-alanine) tetrapeptide with D,D cross-links (meso- D-alanine) pentapeptide a (2E)-but-2-enoyl-[acp] dehydratase 3-phosphate L-glutamine glu degradation I 4-decarboxylase: BR48_RS0113300 UDP-3-O-(3- 3-oxoacyl-[acyl- degradation E2 protein] N 6 -S-[2- ligase: BR48_RS0114155 UDP-3-O-(3- diaminopimelate containing) FabA: fabA acyltransferase: a polycistronic degradation II BR48_RS0112475 hydroxymyristoyl) enoyl-ACP carrier-protein] pyruvate I (aerobic) oxaloacetate succinate methylbutanoyl]dihydrolipoyl- hydroxymyristoyl) L,D-transpeptidase: L,D-transpeptidase: BR48_RS0110240 tRNA precursor asn α glucosamine N- 3-hydroxyacyl- L-lysine meso-diaminopimelate UDP-N-acetyl- -D-muramoyl- glucosamine N- BR48_RS0115590 BR48_RS0115590 reductase FabI: fabI reductase: fabG ammonium asparaginase: acyltransferase: ACP [+ 2 isozymes] gln L-glutamate phe D-ala L-alanyl-D-glutamate acyltransferase: [+ 8 isozymes] a nascent peptidoglycan with a mature peptidoglycan enoyl-ACP a 1,2-diacyl- BR48_RS0103305 L-alanine lpxD [+ 8 isozymes] a mature peptidoglycan dehydratase a (3R,11Z)-3-hydroxy- glutamate degradation I phenylalanine 4- (L-alanyl-γ-D-glutamyl-meso- with (L-alanyl-γ-D-glutamyl- reductase FabI: fabI sn-glycerol a reduced a DNA containing lpxD UDP-2-N,3-O-bis[(3R)- with D,D cross-links (meso- FabZ: fabZ icos-11-enoyl-[acp] synthase: asparaginase: degradation IV monooxygenase: sn-glycerol a CDP- phosphoenol β UDP-N-acetylmuramoyl- a nascent peptidoglycan a nascent peptidoglycan 3-phosphate 34 ubiquinone-6 a nucleoside H O an L-glutamyl- -citryl-L- formate acetyl-CoA D-alanine--D-alanine UDP-2-N-[(3R)-3- 2,6-diaminopimelate) tripeptide meso-2,6-diaminopimeloyl- diaminopimelate containing) a 5,10-gly a uridine electron-transfer an apurinic/ SAH RNA 2 3-hydroxytetradecanoyl]- 3-hydroxyacyl- a tRNA precursor a tRNA precursor with gltB gltD BR48_RS25100 phhA 3-phosphate diacylglycerol triphosphate GTP dGDP pyruvate [tRNA Gln ] ligase: BR48_RS0114120 L-alanyl-D-glutamate-- hydroxydodecanoyl]- with L,D cross links (meso- with (L-alanyl-γ-D-glutamyl- a butanoyl-[acp] phosphatidate glu Degradation/ methylenetetrahydrofolate in tRNA flavoprotein apyrimidinic site glutamine acetyl-CoA α-D-glucosamine D-alanine) tetrapeptide a (2E)-but-2-enoyl-[acp] glu asp ala tyr Asp-tRNA(Asn) 2, 6-diaminopimelate diaminopimelate containing) meso-2,6-diaminopimeloyl- ACP dehydratase cytidylyltransferase: with a 5' extension a 5' extension and NAD-glutamate Utilization/ D-alanine--D-alanine 3-O-[(3R)-3- /Glu-tRNA(Gln) carboxylase ligase: BR48_RS0114170 UDP-2,3- glycine) tetrapeptide beta-ketoacyl-ACP enoyl-ACP FabZ: fabZ BR48_RS0110235 and a long 3' trailer a short 3' extension dehydrogenase: alanine Assimilation - Other electron transfer formate ligase: BR48_RS0102310 hydroxydecanoyl]- a mature peptidoglycan with tRNA uridine-5- CDP-diacylglycerol-- endonuclease 5'-methylthioadenosine/ DNA-directed amidotransferase biotin α diacylglucosamine synthase I: fabB reductase 3-hydroxyacyl-[acyl- BR48_RS0109360 dehydrogenase: ald flavoprotein- GTPase N-formylglutamate dehydrogenase- UDP-N-acetyl-α-D-muramoyl-L-alanyl- -D-glucosamine (L-alanyl-γ-D-glutamyl-meso- phosphatidate acrylonitrile carboxymethylaminomethyl(34) glycerol-3-phosphate 3- III: nth S-adenosylhomocysteine RNA polymerase pyruvate subunit GatB: gatB carboxylase D-alanyl-D-alanine diphosphatase: beta-ketoacyl-ACP FabI: fabI carrier-protein] ribonuclease P 2-oxoglutarate pyruvate ubiquinone HflX: hflX deformylase: hutG N subunit γ-D-glutamyl-meso-2,6-diaminopimelate UDP-2,3- a mature peptidoglycan 2,6-diaminopimelate) tripeptide cytidylyltransferase: degradation I synthesis GTPase MnmE: mnmE phosphatidyltransferase: nucleosidase: subunit alpha: kinase: pyk subunit: accC BR48_RS0112970 synthase II: fabF dehydratase protein component: Detoxification bifunctional DNA- [+ 4 isozymes] Asp-tRNA(Asn) alpha: fdnG diacylglucosamine with L,D cross-links (meso- a mature peptidoglycan enoyl-ACP BR48_RS0118130 ribonuclease ribonuclease D: pgsA oxidoreductase: BR48_RS0104175 BR48_RS0121425 [+ 3 isozymes] UDP-2,3- FabA: fabA BR48_RS0106285 tRNA uridine-5- formamidopyrimidine /Glu-tRNA(Gln) UDP-N- diphosphatase: diaminopimelate containing) with (L-alanyl-γ-D-glutamyl- reductase a CDP- D: rnd BR48_RS0107085 acrylonitrile BR48_RS0102885 [+ 2 isozymes] malonyl-CoA a 3-oxohexanoyl-[acp] carboxymethylaminomethyl(34) glycosylase/ + amidotransferase: BR48_RS0112970 diacylglucosamine meso-2,6-diaminopimeloyl- FabI: fabI ribonuclease nitrile hydratase: reactive oxygen species degradation 1-(3-sn- phosphate H citrate gln an electron- acetylmuramoylalanyl- a (2E,11Z)-icosa-2,11-dienoyl-[acp] diacylglycerol ribonuclease D: arsenate arsenate synthesis enzyme MnmG: mnmG CMP DNA-(apurinic GDP pyruvate gatC gatA CO diphosphatase LpxI: D: rnd ribonuclease PH: a tRNA precursor with Fatty Acid and Lipid Degradation an oxidized S-ribosyl-L- 2 transfer quinol D-glutamyl-2, 6- UDP-2,3- glycine) tetrapeptide 3-oxoacyl-[acyl-carrier- nthB nthA phosphatidyl) + dGTP an L-glutaminyl- BR48_RS0118160 BR48_RS0107085 BR48_RS0107965 detoxification detoxification H ubiquinol-6 or apyrimidinic a butanoyl-[acp] a short 3' extension electron-transfer adenine homocysteine RNA Gln diaminopimelate--D- diacylglucosamine protein] reductase: fabG enoyl-ACP acrylamide superoxide II (glutaredoxin) III (thioredoxin) -sn-glycerol site) lyase: mutM [tRNA ] a 5-carboxymethylaminomethyluridine 34 flavoprotein alanyl-D-alanine ligase: diphosphatase LpxI: lipid X [+ 2 isozymes] reductase FabI: fabI oleate β-oxidation a 7,8-dihydrofolate 3-phosphate beta-ketoacyl- fatty acid β-oxidation I (generic) amidase: superoxide dismutase: arsenate arsenate in tRNA BR48_RS0114165 BR48_RS0118160 enoyl-ACP CDP-diacylglycerol lipid-A- a (3R)-3-hydroxyhexanoyl-[acp] ACP synthase ribonuclease D: BR48_RS0115470 BR48_RS0115200 arsenate arsenate a 3'-terminal a 5'-phospho- reductase FabI: fabI biosynthesis II a tRNA precursor oleate a (3Z)-alk-3- reductase reductase UDP-N-acetyl-α-D-muramoyl-L- lipid X (P. putida) disaccharide I: fabB ribonuclease PH: BR48_RS0107085 [+ 2 isozymes] superoxide dismutase: unsaturated sugar [DNA] with a 5' extension enoyl-CoA (glutaredoxin) (glutaredoxin) alanyl-γ-D-glutamyl-meso-2,6- di-trans,octa-cis-undecaprenyl phosphate synthase: lpxB 3-hydroxyacyl-[acyl- beta-ketoacyl- BR48_RS0107965 ribonuclease long-chain-fatty- BR48_RS0103240 lipid-A- a gondoyl-[acp] DHAP acrylate : arsC : arsC diaminopimeloyl-D-alanyl-D-alanine lipid A disaccharide carrier-protein] ACP synthase D: rnd acid--CoA ligase: disaccharide hydrogen peroxide arsenite a purine base D-glucopyranose a 2,3,4-saturated phosphoenol a peptide with (E. coli) dehydratase FabA: fabA II: fabF ribonuclease P BR48_RS0107235 arsenite ADP-α-D-glucose aminomalonate a RNA-DNA hybrid MoO - β-citryl-L- 7,8-dihydropterin synthase: lpxB lesion in DNA 6-phosphate 1,2-diacyl-sn- asp 2 an N-terminal phospho-N-acetylmuramoyl- protein component: dGTP ATP molybdopterin dADP pyruvate glutamate lipid A tetraacyldisaccharide 3-hydroxyacyl-ACP sn-glycerol acyl-CoA a (2E)-2- glycerol 3-phosphate CTP bifunctional aspartate L-alanine guanine pentapeptide- transferase: a 3-oxohexanoyl-[acp] BR48_RS0106285 catalase: bifunctional aspartate cofactor disaccharide 4'-kinase: dehydratase FabZ: fabZ 3-phosphate synthetase: enoyl-CoA enoyl-CoA transaminase/aspartate deaminase: BR48_RS0114160 BR48_RS0104190 bifunctional DNA- trehalose-6- transaminase/aspartate ribonuclease (P. putida) BR48_RS0104390 queuosine biosynthesis I (de novo) BR48_RS0110440 acyl-CoA hydratase: 4-decarboxylase: guaD 3-oxoacyl- glycerol-3- phosphate phosphatidate 4-decarboxylase: a (2E)-hex-2-enoyl-[acp] BR48_RS0117195 [+ 3 isozymes] arsenite arsenite formamidopyrimidine deoxyguanosinetriphosphate BR48_RS0118820 HI: rnhA molybdenum cofactor N-formylglutamate aminopeptidase undecaprenyldiphospho-N-acetylmuramoyl- tetraacyldisaccharide lipid IV (E. coli) [acyl-carrier- phosphate 1-O- synthetase: H O hydroxyl radical cytidylyltransferase: BR48_RS0118820 pyruvate guanine A oleoyl-CoA enoyl-CoA 2 glycosylase/ synthase: ribonuclease HII: deformylase: hutG N: pepN L-alanyl-γ-D-glutamyl-meso-2,6- 4'-kinase: protein] acyltransferase preQ a 2,3,4-saturated BR48_RS0110440 triphosphohydrolase: BR48_RS0118130 bifunctional aspartate guanylyltransferase deaminase: enoyl-ACP 0 acyl-CoA DNA-(apurinic BR48_RS25270 kinase: pyk diaminopimeloyl-D-alanyl-D-alanine NADPH-dependent 7- hydratase: a 2,3,4- O BR48_RS0111795 bifunctional aspartate BR48_RS0103970 MobA: mobA guaD BR48_RS0104390 reductase: PlsY: plsY acyl-CoA fatty acid long-chain-fatty- 2 phosphatidate transaminase/aspartate reductase FabI: fabI dehydrogenase: BR48_RS0105860 or apyrimidinic transaminase/aspartate 7,8- undecaprenyldiphospho- lipid IV fabG a 1-acyl-sn cyano-7-deazaguanine dehydrogenase: acid--CoA ligase: saturated (3R)-3- cytidylyltransferase: 4-decarboxylase: A enoyl-ACP BR48_RS0113485 site) lyase: mutM α,α-trehalose 4-decarboxylase: citrate dihydrolumazine muramoylpentapeptide beta-N- (P. putida) -glycerol 3- an uncharged tRNA reductase QueF: queF BR48_RS0117920 BR48_RS0107235 a 2,3,4- hydroxyacyl-CoA BR48_RS0110235 BR48_RS0112475 a nucleoside 5'- adenylyl glu ala a peptide reductase FabI: fabI [+ 2 isozymes] a 2,3,4-saturated[+ 8 isozymes] 6-phosphate BR48_RS0112475 DNA pyruvate acetylglucosaminyltransferase: phosphate preQ saturated (3S)-3- triphosphate ADP molybdenum dATP 1 [+ 8 isozymes] fatty acyl CoA 2'-deoxyguanosine gly monophosphate a (3R)-3- 1-acyl-sn-glycerol- 3-hydroxyacyl-CoAhydroxyacyl-CoA a [DNA]- a 5'-phospho- a modified oxaloacetate cofactor murG a hexanoyl-[acp] (2E,9Z)- 4-oxo-2-pentenal hydroxyhexanoyl-[acp] 3-phosphate tRNA guanosine(34) dehydrogenase: nucleotide- [DNA] nucleobase a CDP-2,3,4-saturated- octadecenoyl-CoA lipid II (meso diaminopimelate containing) 3-hydroxyacyl- acyltransferase: transglycosylase Tgt: tgt BR48_RS0118625 3'-phosphate diacylglycerol beta-ketoacyl-ACP enoyl-CoA [acyl-carrier- BR48_RS0110240 a 7-aminomethyl-7- synthase I: fabB hydratase: coenzyme A protein] biotin-carboxyl carrier [+ 2 isozymes] deazaguanosine 34 in tRNA an O 4 - an N-terminal- beta-ketoacyl-ACP BR48_RS0105860 a 5,10- a 2-thiouridine 34 a [bis(guanylyl a [protein]- sn-glycero-3- (S)-1-pyrroline- dehydratase a 1,2-diacyl- a (6S)-5- D-glycerate γ-L-glutamyl- synthase II: fabF protein assembly tRNA preQ1(34) S- methylenetetrahydrofolate molybdopterin) cofactor cys L-cysteine methylthymine glu phospho-N- L-allo-threonine L-methionyl-L- 5-carboxylate glu ala gly a protein sn-glycerol enoyl-CoA a 2,3,4-saturated in tRNA Amino Acid Biosynthesis FabA: fabA adenosylmethionine a 2,3,4-saturated chaperone]-L-cysteine in DNA formyltetrahydrofolate (arachidonoyl) threonyl-[protein] D-glycerate bifunctional D-alanine superpathway of L- superpathway of branched chain amino acid biosynthesis L-tryptophan biosynthesis a [biotin carboxyl- 3-phosphate hydratase: ATP- L-histidine biosynthesis superpathway of L- superpathway of L-serine L-selenocysteine a 3-oxooctanoyl-[acp] 3-hydroxyacyl- ribosyltransferase- fatty acyl CoA 3-ketoacyl- 3-oxoacyl-CoA ethanolamine dehydrogenase: proline isoleucine biosynthesis I carrier protein]-L-lysine BR48_RS0117195 dependent threonine biosynthesis and glycine biosynthesis I biosynthesis I (bacteria) phosphatidate phospholipases CoA thiolase: tRNA uridine-5- methylated-DNA-- BR48_RS0105995 dehydrogenase/L- ACP biotin--[acetyl-CoA- isomerase QueA: queA bifunctional low specificity L- type I methionyl glutamate-- glutathione protease cytidylyltransferase: (S)-3-hydroxy-(9Z) BR48_RS0105330 carboxymethylaminomethyl(34) cysteine desulfurase: glutamate gamma- oxaloacetate PRPP thr pyruvate gln 3-oxoacyl-[acyl-carrier- dehydratase [protein]-cysteine S- folylpolyglutamate glycerophosphodiester threonine aldolase: aminopeptidase: glyoxylate/ cysteine ligase: synthase: subunit chorismate 3-phospho-D-glycerate carboxylase] ligase: BR48_RS0110235 34 a 1,2-diacyl- synthesis GTPase MnmE: mnmE BR48_RS0111395 oxaloacetate ser a tRNA sec protein] reductase: fabG FabZ: fabZ an epoxyqueuosine in tRNA -octadecenoyl-CoA methyltransferase: semialdehyde bifunctional BR48_RS0117420 sn-glycerol synthase/ phosphodiesterase: BR48_RS0100260 map hydroxypyruvate BR48_RS0104640 gshB HslV: hslV ATP acetolactate bifunctional phosphoglycerate [+ 2 isozymes] phosphatidate 3-hydroxyacyl-CoA a phosphatidylcholine tRNA uridine-5- cysteine BR48_RS24195 dehydrogenase aspartate threonine/serine a [biotin carboxyl- tRNA 3-phosphate dihydrofolate BR48_RS0118090 reductase A: a peptide phosphoribosyltransferase synthase: ilvN aspartate dehydrogenase: a (2E)-hex-2-enoyl-[acp] cytidylyltransferase: dehydrogenase: carboxymethylaminomethyl(34) desulfurase: sufS PutA: putA transaminase/ dehydratase: anthranilate selenide carrier protein]-N epoxyqueuosine(34) [+ 2 isozymes] synthase: BR48_RS0105750 regulatory subunit: BR48_RS0113860 transaminase/ BR48_RS0116405 serine- a (3R)-3-hydroxyoctanoyl-[acp] BR48_RS0118130 synthesis enzyme MnmG: mnmG an N-terminal L- γ-L-glutamyl- aspartate 4- synthase: 6 BR48_RS0118625 acetyl-CoA BR48_RS0108455 acetaldehyde norophthalmate BR48_RS0120320 -biotinyl-L-lysine reductase QueG: queG a 1-acyl-sn a [bis(guanylyl molybdopterin) gly met threonyl-[protein] hydroxypyruvate glu D-alanine decarboxylase: BR48_RS0104560 aspartate 4- BR48_RS0123005 phosphoglycerate -tRNA selenide, enoyl-ACP a CDP- 3-oxo-(9Z)- anandamide sn-glycerol [+ 2 isozymes] (S)-2-acetolactate 3-hydroxyacyl-[acyl- a phosphatidylcholine -glycero-3- ala cofactor chaperone]- a thymine in DNA a [protein]-S- ATP decarboxylase: dehydrogenase: ligase: water reductase diacylglycerol a queuosine 34 in tRNA 3-phosphate BR48_RS0118820 octadecenoyl-CoA phosphocholine a 5-aminomethyl-2- S-sulfanyl-L-cysteine methyl-L-cysteine (2Z)-2-aminobut- BR48_RS0118820 BR48_RS0110535 serS dikinase carrier-protein] FabI: fabI C1 Compound Utilization and Assimilation a 7,8-dihydrofolate a (6S)-5- phosphoribosyltransferase: ketol-acid thiouridine 34 in tRNA bifunctional anthranilate PRPP dehydratase FabA: fabA a [biotin carboxyl- 3-ketoacyl- BR48_RS0104555 2-enoate reductoisomerase: 3-phosphooxypyruvate SelD: selD enoyl-ACP formyltetrahydrofolate aspartate bifunctional carrier-protein dimer]- CoA thiolase: a 2-acyl-sn ilvC an L-seryl- 3-hydroxyacyl-ACP reductase formaldehyde oxidation transaminase/ 1-(5-phospho- aspartate phosphoserine 6 BR48_RS0105330 a phosphatidylcholine -glycero-3- formaldehyde oxidation formaldehyde oxidation VI (H MPT pathway) formate oxidation to CO (2R)-2,3- sec selenophosphate dehydratase FabZ: fabZ N -biotinyl-L-lysine VII (THF pathway) formate assimilation into 5,10- 4 2 β anthranilate [tRNA ] FabI: fabI an O 6 - β an unstable aspartate 4- -D-ribosyl)-ATP transaminase/ transaminase: acetyl-CoA acetyl-CoA phosphocholine II (glutathione-dependent) methylenetetrahydrofolate 3-methyl-2- 5,10-methylene- a [DNA]-3'- a 5'-phospho- a [protein]- lipid II (meso N-acetyl- -D- dihydroxy-3- phosphatidylcholine lipoprotein posttranslational modification (7Z)-hexadecenoyl-CoA NAD + an adenosine 37 acetyl-CoA propanoyl-CoA D-glycerate 4-hydroxy- phosphoribosyl-ATP aspartate 4- phosphoribosyltransferase: trpD BR48_RS0110530 methylguanine diaminopimelate DMAPP glucosaminyl-(1 met RecA filament- decarboxylase: 2-iminobutanoate methylbutanoate a (2E)-oct-2-enoyl-[acp] a hexanoyl-[acp] carboxylase carboxylase formaldehyde formaldehyde formate oxobutanoate tetrahydromethanopterin hydroxyl [DNA] L-cysteine L-threonine purine decarboxylase: biosynthesis VI formaldehyde in DNA containing) in tRNA DNA complex BR48_RS0112475 diphosphatase: L-seryl-tRNA(Sec) carboxyltransferase biotin a [prolipoprotein]- acyl-CoA phospholipase C, formate formaldehyde- -> 4)-N-acetyl- glyoxylate/ bifunctional DNA dihydroxy-acid formate dehydrogenase: β BR48_RS0108550 BR48_RS0112475 N-(5-phosphoribosyl)-anthranilate O-phospho-L-serine selenium enoyl-ACP subunit beta: carboxylase a CDP- dehydrogenase: phosphocholine- formate-- -D-muramate hydroxypyruvate xanthine repair asp dehydratase: beta-ketoacyl- choline L-cysteine activating enzyme: fae fdxH BR48_RS0120515 3-methyl-2-oxobutanoate DNA acetyl-CoA C- glutamate N- β asp transferase: reductase FabI: fabI BR48_RS0108450 subunit: accC diacylglycerol BR48_RS0117920 specific: tetrahydrofolate methylated-DNA-- monofunctional tRNA (adenosine(37)-N6) reductase A: low specificity L- dehydrogenase: protein 1-(5-phospho- - ilvD ammonia assimilation cycle III ACP synthase prolipoprotein a 5,10- S-(hydroxymethyl) formaldehyde- formate dehydrogenase hydroxymethyltransferase: ligase acetyltransferase: acetyltransferase/ D-ribosyl)-AMP phosphoribosylanthranilate phosphoserine BR48_RS0120525 enoyl-ACP a [carboxyl-carrier BR48_RS0111810 methylenetetrahydrofolate ligase: [protein]-cysteine S- biosynthetic -dimethylallyltransferase beta-N- BR48_RS0105750 threonine aldolase: xdhB xdhA amino-acid RecO: aspartate kinase: dihydroxy-acid I: fabB diacylglyceryl [+ 8 isozymes] glutathione activating enzyme: fae subunit alpha: BR48_RS0100610 D: ligD BR48_RS0109860 isomerase: BR48_RS0108435 6 phosphatidylcholine/ methyltransferase: MiaA: miaA 2-oxobutanoate phosphatase SerB: serB reductase FabI: fabI protein dimer]-N - 10 BR48_RS0123010 peptidoglycan acetylhexosaminidase: D-glycerate BR48_RS0100260 xanthine acetyltransferase recO BR48_RS0101225 phosphoribosyl- dehydratase: aspartate kinase: beta-ketoacyl- transferase: (2E,7Z)- phospholipase C, bifunctional an N - 5,10-methylene-tetrahydromethanopterin BR48_RS0104310 [+ 4 isozymes] [+ 2 isozymes] a stabilized an L- ammonium carboxybiotinyl-L-lysine phosphatidylserine glutathione- 3-methyl-2-oxobutanoate BR48_RS24195 transglycosylase: nagZ dehydrogenase: dehydrogenase: AMP ilvD BR48_RS0101225 1-(2-carboxyphenylamino)-1- ACP synthase BR48_RS0122780 hexadecenoyl-CoA phosphocholine- methylenetetrahydrofolate formyltetrahydrofolate CO ArgJ: argJ RecA filament- acetolactate selenocysteinyl- an octanoyl-[acp] synthase: dependent 2 hydroxymethyltransferase: [+ 2 isozymes] 6 BR48_RS0105995 cyclohydrolase: deoxy-D-ribulose 5-phosphate ser II: fabF a [prolipoprotein]- specific: dehydrogenase/ mtgA N -(3-methylbut- xdhB xdhA N-acetyl-L- DNA complex L-aspartyl- synthase: ilvN 3-methyl-2- [tRNA sec ] glu BR48_RS0121815 enoyl-CoA formaldehyde bifunctional panB glycolaldehyde hisI L-aspartyl- glutamine S-1,2-diacyl-sn- methenyltetrahydrofolate 2-en-1-yl)- N-acetyl-D- 3-oxopentanoyl- hydroxypyruvate gly 8-hydroxypurine methionine 4-phosphate BR48_RS0113860 indole-3-glycerol 2-oxoglutarate hydratase: BR48_RS0103550 a 1,2-diacyl- methylenetetrahydrofolate [DNA] NMN oxobutanoate serine glutamate synthetase: beta-ketoacyl-ACP dehydrogenase: AMP a [protein]-S- adenosine 37 GlcNAc CoA 1-(5-phospho-β-D-ribosyl)- 4-phosphate phosphate a 3-oxooctanoyl-[acp] glyceryl-L-cysteine BR48_RS0105860 a phosphatidylcholine cyclohydrolase FolD: folD a guanine in DNA lipid II (meso di-trans,octa-cis muramate (S)-2-aceto-2- hydroxymethyltransferase: synthase: synthase I: fabB sn-glycerol BR48_RS0119330 dehydrogenase/ 5,10-methenyltetrahydromethanopterin aspartate- 5-[(5-phosphoribosylamino) synthase TrpC: trpC BR48_RS0115045 a phosphatidylcholine a 5,10- methyl-L-cysteine diaminopimelate -undecaprenyl in tRNA hydroxybutanoate 2-isopropylmalate aspartate- enoyl-CoA methenyltetrahydrofolate 2-dehydropantoate THMPT semialdehyde methylideneamino]imidazole- branched-chain BR48_RS0116890 gltB gltD [+ 3 isozymes] beta-ketoacyl-ACP 3-oxoacyl- signal peptidase II: S-(hydroxymethyl) containing) diphosphate synthase: leuA semialdehyde (1S,2R)-1-C-(indol-3- hydratase: a 1-phosphatidyl- methenyltetrahydrofolate cyclohydrolase FolD: folD methenyltetrahydromethanopterin dehydrogenase: 4-carboxamide ketol-acid amino acid synthase II: fabF [acyl-carrier- BR48_RS0106985 a 1,2-diacyl- glutathione aminotransferase: dehydrogenase: yl)glycerol 3-phosphate gly Asp-tRNA(Asn) BR48_RS0117195 1D-myo-inositol bifunctional a 5,10- cyclohydrolase: BR48_RS0119645 BR48_RS0108785 1-(5-phosphoribosyl)-5- reductoisomerase: protein] sn-glycerol dehydrogenase/ (2S)-2- BR48_RS0122710 BR48_RS0108785 /Glu-tRNA(Gln) a 3-oxodecanoyl-[acp] an (S-diacyl-sn- 4,5-bisphosphate methylenetetrahydrofolate methenyltetrahydrofolate a [protein]- a DNA methyl an (R)-2- an N-terminal- L-aspartate 4- [(5- phosphoribosylamino) ilvC tryptophan ammonium gln reductase: a lipoprotein (S)-3-hydroxy-(7Z) class III alcohol cob(II)inamide a lipid II a peptidoglycan L-cysteate a peptide with a 1-butanesulfonate D-glycerate an unfolded isopropylmalate amidotransferase glyceryl)-L-cysteinyl- dehydrogenase/ 5-formyl-tetrahydromethanopterin L-cysteine phosphotriester halocarboxylate L-methionyl-L- methylideneamino]imidazole-4- (R)-2,3-dihydroxy- branched-chain L-aspartate 4- synthase: trpB L-methionine biosynthesis III fabG signal peptide -hexadecenoyl-CoA dehydrogenase: bifunctional ATP leader sequence hypoxanthine dGDP protein semialdehyde subunit GatB: gatB 3-oxoacyl-[acyl-carrier- [apolipoprotein] methenyltetrahydrofolate bifunctional aspartate D-glycerate alanyl-[protein] 3-methylpentanoate 3-isopropylmalate amino acid semialdehyde BR48_RS0108445 3-hydroxyacyl-CoA BR48_RS0106775 methylenetetrahydrofolate chaperonin homoserine carboxamide isomerase: hisA [+ 7 isozymes] [+ 2 isozymes] signal peptide transaminase/aspartate dehydrogenase: xanthine vitamin B12- dehydratase protein] reductase: fabG fatty acid elongation -- saturated apolipoprotein N- dehydrogenase: cyclohydrolase FolD: folD dehydrogenase/ monofunctional GroEL: groL dihydroxy-acid aminotransferase: homoserine ser peptidase Aldehyde Degradation methylated-DNA-- HAD family FMNH2-dependent dependent dehydrogenase: phosphoribulosylformimino- L-lysine biosynthesis I indole [+ 2 isozymes] a (3R)-3- 10 4-decarboxylase: BR48_RS0105995 dehydrogenase: small subunit: leuD BR48_RS0103245 L-homoserine acyltransferase: lnt BR48_RS0118625 an N - S-formylglutathione methenyltetrahydrofolate cob(I)yrinic acid a,c-diamide biosynthetic signal type I methionyl chaperonin BR48_RS0111580 AICAR-phosphate dehydratase: dehydrogenase: SppA: sppA [protein]-cysteine S- hydrolase: BR48_RS0118820 alkanesulfonate xdhB xdhA ribonucleotide 3-isopropylmalate hydroxyoctanoyl-[acp] an N-acyl-(S-diacyl- formyltetrahydrofolate cyclohydrolase FolD: folD adenosyltransferase: peptidoglycan peptidase glyoxylate/ aminopeptidase: GroEL: groL ilvD BR48_RS0111580 homoserine O- a (3R)-3-hydroxydecanoyl-[acp] an acetoacetyl-[acp] 3-oxo-(7Z)- methylglyoxal degradation I formate methyltransferase: BR48_RS0107105 monooxygenase: reductase: homoserine dehydratase glu 3-hydroxyacyl- sn-glyceryl)-L- S-formylglutathione BR48_RS0111045 transglycosylase: bifunctional aspartate I: lepB hydroxypyruvate map xanthine a protein dihydroxy-acid asp homoserine tryptophan acetyltransferase: a peptide hexadecenoyl-CoA formyltetrahydrofolate a 5,10- BR48_RS0108005 HAD family ssuD BR48_RS0112255 dehydrogenase: imidazole large subunit: leuC val [acyl-carrier- cysteinyl-[lipoprotein] hydrolase: fghA cob(I)yrinic acid a,c-diamide mtgA transaminase/aspartate reductase A: dehydrogenase: dehydratase: dehydrogenase: synthase: trpB BR48_RS0110915 3-hydroxyacyl-[acyl- 3-ketoacyl- deformylase: purU methylenetetrahydrofolate [+ 2 isozymes] hydrolase: GDP BR48_RS0122285 glycerol aspartate kinase: protein] methylglyoxal adenosyltransferase: cobO 4-decarboxylase: BR48_RS0105750 xdhB xdhA ilvD BR48_RS0122285 BR48_RS0108445 carrier-protein] CoA thiolase: formate BR48_RS0107395 an N-terminal L- 6,8- phosphate 2-isopropylmaleate BR48_RS0101225 O-acetyl-L- dehydratase lactoylglutathione lyase: BR48_RS0112475 a leader sequence a peptide sulfite hydroxypyruvate met dehydratase FabA: fabA BR48_RS0105330 formate di-trans,octa-cis 1-butanal alanyl-[protein] dihydroxypurine L-homoserine synthase: (3S)-3-methyl-2- hydrogen sulfide BR48_RS0122735 a peptidoglycan a [protein]-S- 3-sulfopyruvate 3-isopropylmalate L-aspartyl-4-phosphate L-homoserine homoserine FabA: fabA adenosylcobinamide -undecaprenyl [DNA] hisF hisH oxopentanoate trp 3-hydroxyacyl-ACP a 3-oxoacyl-[acp] (5Z)-tetradecenoyl-CoA lactoylglutathione lyase: triphosphate methyl-L-cysteine an (S)-2- dehydratase 3-hydroxyacyl- periplasmic disulfide bond formation diphosphate a halide anion homoserine kinase: branched-chain dehydratase FabZ: fabZ BR48_RS0117655 hydroxycarboxylate small subunit: leuD aspartate- O-acetylhomoserine ACP BR48_RS0103675 D-erythro-1- amino acid homoserine kinase: a [DsbB protein] a [DsbA protein] two reduced acyl-CoA (R)-S-lactoylglutathione AICAR semialdehyde aminocarboxypropyltransferase: a (2E)-dec-2-enoyl-[acp] dehydratase an electron- (imidazol-4- aminotransferase: 3-isopropylmalate BR48_RS0103675 with reduced L- carrying a cysteine residues dehydrogenase: dehydrogenase: an N-terminal- O-phospho- yl)-glycerol dehydratase BR48_RS0117205 FabZ: fabZ beta-ketoacyl- transfer quinone a cytosine 32 an [L-cysteine an (S)-2- a peptide with (R)-3- BR48_RS0122710 L-arginine biosynthesis II (acetyl cycle) beta-ketoacyl- cysteine residues disulfide bond in a protein BR48_RS0113485 hydroxyacylglutathione cob(II)alamin MoO - an alkylated DNA BR48_RS0108785 O-phospho- enoyl-ACP 2 desulfurase]-S- a PII protein an N-terminal L-methionyl-L- Ins(1)P L-homoserine 3-phosphate large subunit: leuC ACP [+ 8 isozymes] hydrolase: gloB ATP GTP in tRNA halocarboxylate hydroxybutanoate dADP GTP branched-chain L-homoserine a (2E)-oct-2-enoyl-[acp] ACP synthase molybdopterin sulfanyl-L-cysteine UTP L-proline 3-hydroxybutyrate seryl-[protein] imidazoleglycerol- (2R,3S)-3- L-aspartate 4- reductase FabI: fabI reductase: phbB molybdopterin inositol threonine synthase: amino acid N-acetylglutamyl- L-homocysteine II: fabF (2E,5Z)- cofactor dehydrogenase: vitamin B12- phosphate isopropylmalate semialdehyde enoyl-ACP [+ 2 isozymes] (R)-lactate monophosphatase: diguanylate BR48_RS0103635 aminotransferase: threonine synthase: phosphate enoyl-ACP tetradecenoyl-CoA HAD family DNA-3- dependent dehydratase reductase FabI: fabI beta-ketoacyl- cob(I)yrinic acid a,c-diamide tRNA 2- [protein-PII] BR48_RS0109810 type I methionyl BR48_RS0110405 cyclase: BR48_RS0103245 3-isopropylmalate 4-hydroxy- BR48_RS0103635 methionine methionine reductase hydrolase: methyladenine prolyl ribonucleotide HisB: hisB ACP synthase adenosyltransferase: cobO molybdenum cofactor thiocytidine(32) uridylyltransferase: 3-hydroxybutyrate aminopeptidase: BR48_RS25085 dehydrogenase: tetrahydrodipicolinate N-acetyl- FabI: fabI a 2,3,4-saturated a (3R)-3-hydroxyacyl- enoyl-CoA BR48_RS0107105 glycosylase: aminopeptidase: pip inositol reductase: thr 3-(imidazol-4- synthase: synthase: a decanoyl-[acyl-carrier protein] I: fabB 3-hydroxyacyl- guanylyltransferase synthetase dehydrogenase: map thr gamma- fatty acyl-[acp] [acyl-carrier protein] hydratase: cob(I)yrinic acid a,c-diamide BR48_RS0114750 BR48_RS0107000 monophosphatase: BR48_RS0112255 c-di-GMP yl)-2-oxopropyl ile leuB synthase: metH metH enoyl-ACP MobA: mobA TtcA: ttcA HAD family glutamyl- ACP dehydratase adenosyltransferase: BR48_RS0107565 BR48_RS0114475 (2S)-2-isopropyl- BR48_RS24810 beta-ketoacyl-ACP reductase (3E,5Z)-tetradeca- BR48_RS0117195 pyruvate hydrolase: ADP threonine/serine phosphate phosphate 5-methyltetrahydrofolate- 5-methyltetrahydrofolate- FabZ: fabZ BR48_RS0111045 acetoacetate 3-oxosuccinate enoyl-CoA an [L-cysteine BR48_RS0107395 a DNA containing an N-terminal myo-inositol dehydratase: histidinol-phosphate 4-hydroxy- -homocysteine -homocysteine synthase I: fabB FabI: fabI 3,5-dienoyl-CoA bis(guanylyl a 2-thiocytosine 32 an alkylated a uridylylated reductase: 3-hydroxyacyl- a peptide pro met L-seryl-[protein] hydratase: desulfurase]- nucleobase an apurinic/ PII protein BR48_RS0120320 transaminase: tetrahydrodipicolinate acetylglutamate argC methyltransferase: methyltransferase: beta-ketoacyl-ACP [acyl-carrier- acyl-CoA molybdopterin) in tRNA an octanoyl-[acp] BR48_RS0105860 Inorganic Nutrient Metabolism adenosylcobalamin L-cysteine apyrimidinic site [+ 2 isozymes] BR48_RS0110920 synthase: kinase: argB BR48_RS0113565 BR48_RS0113565 synthase II: fabF protein] thioesterase: triphosphate cofactor an (S)-2- BR48_RS0102535 gln N-acetyl-L-glutamate BR48_RS0115225 a halide anion (2Z)-2-aminobut- L-histidinol L-phenylalanine 4-methyl-2- glu N-acetyl-L-glutamate dehydratase hydroxycarboxylate (2S,4S)-4- 5-semialdehyde L-citrulline biosynthesis met a 3-oxododecanoyl-[acp] enoyl-ACP DsbA family (S)-3-hydroxy-(5Z) (aminomethyl)phosphonate degradation 2-enoate phosphate biosynthesis I oxopentanoate bifunctional FabA: fabA [+ 3 isozymes] glyphosate degradation III methylphosphonate dimethyl sulfide thiosulfate oxidation III (multienzyme complex) hydroxy-2,3,4,5- N-acetylornithine reductase oxidoreductase: -tetradecenoyl-CoA glutamate N- glutamine- (3E,5Z)- degradation I degradation histidinol- branched-chain tetrahydrodipicolinate 3-oxoacyl-[acyl-carrier- a 2,3,4-saturated FabI: fabI a trans-2-enoyl- BR48_RS0121780 3-hydroxyacyl-CoA UDP-N-acetyl-α-D-muramoyl- MoO - a peptidoglycan an N-terminal- N-acetyl-D- (2R,3S)-3- chorismate acetyltransferase/ hydrolyzing bifunctional aminotransferase: gln L-cysteine biosynthesis I Tetrapyrrole Biosynthesis a [DsbB protein] a [DsbA protein] tetradecadienoate (aminomethyl)phosphonate di-trans,octa-cis- 2 3-methylbutanoate a ribonucleoside a single a phosphate N-ethylglycine phosphatase: amino acid 4-hydroxy- protein] reductase: fabG fatty acyl-[acp] [acyl-carrier protein] an electron- an intra- glyphosate II (oxidation) a [SoxY protein]-L-cysteine L-alanyl-γ-D-glutamyl-L- molybdopterin dimer (generic) L-methionyl-L- galactosamine 3',5'-ADP a DNA segment carbamoyl- BR48_RS0105275 enoyl-ACP carrying a with reduced L- dehydrogenase: undecaprenyl phosphate cys triphosphate isopropylmalate monoester hisN chorismate mutase: amino-acid glutamate N- methylphosphonate stranded DNA 6-phosphate aminotransferase: tetrahydrodipicolinate [+ 2 isozymes] reductase transfer quinol protein disulfide BR48_RS0118625 phosphonate dimethyl sulfide lysyl-D-alanyl-D-alanine cofactor cysteinyl-[protein] 3-isopropylmalate 3'(2'),5'-bisphosphate alkaline 2-iminobutanoate BR48_RS0109300 acetyltransferase phosphate acetyltransferase/ Asp-tRNA(Asn) superpathway of heme b disulfide bond cysteine residues phosphonate BR48_RS0122710 reductase: ser C-P lyase dehydratase nucleotidase CysQ: phosphatase: recombinase histidinol ArgJ: argJ synthase: amino-acid /Glu-tRNA(Gln) FabI: fabI biosynthesis from glutamate 3-oxo-(5Z)- (acetamidomethyl)phosphonate C-P lyase acetate- lytic glycine prephenate BR48_RS0108190 a (3R)-3-hydroxydodecanoyl-[acp] system protein phospho-N- DNA primase: large subunit: leuC RecA: recA branched-chain carA carB tetradecenoyl-CoA system protein molybdenum -CoA transglycosylase type I methionyl N-acetylglucosamine- BR48_RS0104410 BR48_RS0110010 oxidase acetyltransferase amidotransferase PhnL: phnL BR48_RS0122335 histidinol amino acid (S)-2,3,4,5- serine O- phosphonate C- a [SoxY protein]-S- acetylmuramoyl- cofactor sulfurase: F: BR48_RS24500 aminopeptidase: 6-phosphate 3-isopropylmalate 3'(2'),5'-bisphosphate alkaline a DNA segment prephenate ArgJ: argJ subunit GatB: gatB 3-hydroxyacyl-[acyl- 3-ketoacyl- PhnL: phnL dimethyl sulfoxide ligase: acs ThiO: thiO dehydrogenase: aminotransferase: tetrahydrodipicolinate carbamoyl phosphate L-ornithine acetyltransferase: enoyl-ACP glu α-D-ribose-1-[[+N 2- isozymes] pentapeptide- bifunctional DNA map deacetylase: nagA dehydratase in reverse dehydratase: 5-oxo-L-proline metabolism CoA thiolase: P lyase system α [+ 2 isozymes] sulfosulfanyl-L-cysteine BR48_RS0114285 [+ 9 isozymes] nucleotidase phosphatase: pro [+ 7 isozymes] cysE carrier-protein] reductase glutamate-- -D-ribose-1- transferase: small subunit: leuD orientation 2-oxobutanoate hisD BR48_RS0105705 BR48_RS0103245 2,3,4,5- N-acetyl-L-ornithine BR48_RS0105330 protein PhnL: phnL (phosphonomethyl) primase/polymerase: CysQ: cysQ BR48_RS0109290 dehydratase FabA: fabA FabI: fabI tRNA ligase: methylphosphonate- BR48_RS0114160 3-methylbutanoyl- (2S)-2- histidinol tetrahydropyridine- a [protein] with a [protein] with glycine] 5-triphosphate cytochrome c: Mo(O)(S)- diphosphate BR48_RS0105535 D-galactosamine ethylamine glyoxylate 3-phenyl-2- glu O-acetyl-L-serine BR48_RS0118175 (3Z)-dodec- [+ 2 isozymes] 5-triphosphate CoA GlcNAc-1,6- an N-terminal L- isopropylmalate an alcohol acetolactate leu bifunctional hydrogen sulfide 3-hydroxyacyl-ACP enoyl-ACP an N-terminal an N-terminal α-D-ribose 1- alpha-D-ribose 1- molybdopterin AMP a lipid II acetate AMP dehydrogenase: oxopropanoate 2,6-dicarboxylate N- 3-enoyl-CoA alpha-D-ribose 1- BR48_RS0103195 ala anhydro-MurNAc- met cysteinyl-[protein] 6-phosphate synthase: ilvN proline dehydratase FabZ: fabZ reductase glutamate-- L-glutamine L-glutamate (acetamidomethylphosphonate) methylphosphonate dimethyl sulfone undecaprenyl-diphospho-N- cofactor hisD succinyltransferase: glutamate 5-kinase: methylphosphonate UMP ssDNA/pppN(pN) pentapeptide BR48_RS0113860 bifunctional L-arginine degradation dehydrogenase/L- FabI: fabI tRNA ligase: 5-triphosphate a [SoxY protein]-S- a [SoxY protein]-S γ L-proline biosynthesis dapD 5-triphosphate 5-triphosphate acetylmuramoyl-L-alanyl- -D- hybrid aspartate ornithine BR48_RS0109690 cysteine synthase A: a (2E)-dodec-2-enoyl-[acp] n -1 (S)-2-aceto-2- histidinal I (from L-glutamate) I (arginase pathway) glutamate gamma- BR48_RS0112985 alpha-D-ribose 1- diphosphatase: disulfanyl-L-cysteine -sulfanyl-L-cysteine glutamyl-L-lysyl- D-alanyl-D-alanine transaminase/ N-succinyl-2-amino- BR48_RS0112150 an L-glutamyl- diphosphatase: carbamoyltransferase: semialdehyde Glu BR48_RS0113215 selenate reduction hydroxybutanoate 6-ketopimelate γ-L-glutamyl enoyl-ACP [tRNA ] (2E)-dodec- methylphosphonate histidinol aspartate 4- argF dehydrogenase cysteine a [protein] with α-D-ribose-1-[N- BR48_RS0113215 ketol-acid glu arg 5-phosphate reductase FabI: fabI 2-enoyl-CoA 5-triphosphate α-D-ribose-1- α dehydrogenase: decarboxylase: PutA: putA synthase A: cysK γ-L-glutamyl (phosphonomethyl) methanesulfinate UDP-N-acetyl- -D- a mismatched 4-nitrophenyl reductoisomerase: an N-terminal 5- glutathione diphosphatase: di-trans,octa-cis- pyruvate an acyl-[acyl- 5'-deoxyadenosine carbamoyl O-ureido-L- meso-tartrate CAIR hisD BR48_RS0118820 arginase: enoyl-ACP 5-phosphate enoyl-CoA methylphosphonate selenate muramoyl-L-alanyl-γ-D- L-ornithine DNA base pair asp butanoate sarcosine glutamate 5-kinase: long-chain fatty oxo-L-proline BR48_RS0113215 glycine] 5-phosphate undecaprenyl phosphate carrier protein] phosphate IMP ilvC (S)-1-pyrroline- glutamate-5- fatty acid biosynthesis hydratase: 5-phosphate sulfate glutamyl-L-lysyl-D-alanine DNA homoserine tartrate 5-(carboxyamino) histidinol BR48_RS0109690 rocF reductase FabI: fabI acid activation α-D-ribose-1-(2-N- alpha-D-ribose 1- a [SoxY protein]-S-(2- (R)-2,3-dihydroxy- bifunctional γ-L-glutamyl N-succinyl-L,L-2,6- 5-carboxylate semialdehyde cys initiation (type II) (S)-4-amino-5- alpha-D-ribose 1- adenylyltransferase: mismatch dehydrogenase: pyrimidine 5'- imidazole dehydrogenase: L-ornithine BR48_RS0105860 acetamidomethylphosphonate) methylphosphonate sulfodisulfanyl)-L-cysteine aspartate diaminopimelate methylphosphonate pyruvate, 5'-methylthioadenosine/ BR48_RS0118695 nucleotidase: 3-methylpentanoate 5-phosphate dehydrogenase: a dodecanoyl-[acp] a long-chain oxopentanoate enoyl-CoA 5-phosphate C- adenosine 5'-cysN cysD phospho-N- phosphate ornithine repair protein argininosuccinate arylesterase: ribonucleotide hisD transaminase/ acetyl-CoA 5-phosphate phosphate dikinase: S-adenosylhomocysteine glycine oxidase BR48_RS0106235 dihydroxy-acid succinyl- L-citrulline BR48_RS0109695 fatty acid glutamate-1- TCA cycle 5-phosphate C- methanesulfonate acetylmuramoyl- acyltransferase carbamoyltransferase: MutS: mutS synthase: BR48_RS0108860 tartrate mutase: purE aspartate 4- glutamate-5- ornithine--oxo-acid acyl-CoA hydratase: alpha-D-ribose 1- P-lyase PhnJ: phosphoselenate BR48_RS0103580 nucleosidase: ThiO: thiO diaminopimelate acetyl-CoA semialdehyde 5-oxo-L-proline P-lyase PhnJ: PlsX: plsX argF DNA mismatch [+ 2 isozymes] AIR dehydratase: his semialdehyde transaminase: synthetase: BR48_RS0117195 methylphosphonate 5- BR48_RS0113260 pentapeptide- BR48_RS0104175 BR48_RS0108810 dehydrogenase: decarboxylase: desuccinylase: beta-ketoacyl-ACP carboxylase BR48_RS0113260 FMNH2-dependent ilvD dehydrogenase: BR48_RS0117970 argininosuccinate L-glutamate-5- 2,1-aminomutase: TCA cycle I (prokaryotic) (S)-3- phosphate C-P-lyase α transferase: repair protein MutS: BR48_RS0118700 inosine BR48_RS0112475 uracil degradation synthase I: fabB carboxyltransferase BR48_RS0110440 5-phospho- -D-ribose alkanesulfonate 2-hydroxy-3- dapE synthase: BR48_RS23970 5-oxoprolinase: carbon-phosphorus phosphoenol + BR48_RS0108605 butanoate 4-nitrophenol dihydroxy-acid BR48_RS0109695 L-glutamate-5- I (reductive) semialdehyde hydroxydodecanoyl-CoA PhnJ: BR48_RS0113260 1,2-cyclic phosphate assimilatory BR48_RS0114160 diphosphate H arg L-glutamate beta-ketoacyl-ACP subunit beta: long-chain-fatty- BR48_RS0114215 monooxygenase: AMP pyruvate a properly matched canavaninosuccinate glyoxylate methylamine oxosuccinate dehydratase: BR48_RS0108810 3-hydroxyacyl-CoA lyase complex selenite sulfate reduction IV acyl-carrier protein an acyl phosphate 5-deoxy-D-ribose L-citrulline phe L-glutamate-5- L,L-diaminopimelate semialdehyde synthase II: fabF laurate BR48_RS0108450 acid--CoA ligase: 5-aminolevulinate acetyl-CoA carbon-phosphorus ssuD DNA base pair ilvD uracil biosynthesis III subunit PhnI: undecaprenyl-diphospho-N adenine semialdehyde L-arginino-succinate ornithine--oxo-acid malonyl-CoA BR48_RS0107235 dehydrogenase: lyase complex subunit UMP L-alanine bifunctional long-chain-fatty- a long-chain glu BR48_RS0113265 sulfate -acetylmuramoyl-L-alanyl-γ- (3S)-3-methyl-2- alanine diaminopimelate transaminase: arginase: porphobilinogen BR48_RS0118625 PhnI: BR48_RS0113265 α sulfite proline 2-oxoglutarate acid--CoA ligase: fatty acyl-CoA oxaloacetate 5-phospho- - sulfate oxopentanoate biosynthesis III racemization BR48_RS0117970 a 3-oxotetradecanoyl-[acp] ACP S- α-D-ribose 1,5- D-glutamyl-L-lysyl- D-alanine epimerase: dehydrogenase/L- argininosuccinate rocF glutamate synthase: hemB 5-phospho-α-D-ribose D-ribose 1,2- adenylyltransferase: 5,6-dihydrouracil BR48_RS0107235 malonyltransferase: citrate (Si)-synthase: gltA 3-oxododecanoyl-CoA bisphosphate branched-chain BR48_RS0108940 glutamate gamma- lyase: argH synthase: 1,2-cyclic phosphate cyclic phosphate selenodiglutathione cysN cysD 6 cys (S)-1-pyrroline- 3-oxoacyl-[acyl-carrier- acyl-CoA synthetase: fabD porphobilinogen an N -L- di-trans,octa-cis an N-formyl-L- a peptide with a [lipoyl-carrier 6-O-α-mycolyl- amino acid glycine ala semialdehyde gltB gltD 3-ketoacyl- ribose 1,5- APS UDP-α-D-glucose dihydropyrimidinase: L-ornithine BR48_RS0110440 a sulfurated 37 2-methylbutanoate RNA γ carbonic acid L-tartrate 6 aminotransferase: cysteine alanine 5-carboxylate meso-diaminopimelate protein] reductase: fabG 6 37 threonylcarbamoyladenine -undecaprenyl methionylaminoacyl- an N-terminal -L-glutamyl-(S)- gly Ins(2)P protein]-N -[(R) trehalose 6- biosynthesis IV dehydrogenase arg hydA glu a malonyl-[acp] N -L-threonylcarbamoyladenosine CoA thiolase: bisphosphate desulfurase: sufS hydroxymethylbilane [sulfur carrier] in tRNA phosphate Xaa-L-proline 2-aminobutanoate tartrate -dihydrolipoyl]- phosphate BR48_RS0122710 racemase: pyrroline-5- PutA: putA [+ 2 isozymes] lauroyl-CoA malate dehydrogenase: mdh -modified tRNA biosynthesis BR48_RS0105330 phosphokinase: adenylyl-sulfate tRNA inositol ornithine synthase: hemC (S)-malate citrate α-D-ribose 1,5- dehydrogenase: trehalose- branched-chain cysteine desulfurase: alr carboxylate diaminopimelate 3-ureidopropanoate phnN kinase: cysN monophosphatase: L-lysine dihydrolipoyl thr carbamoyltransferase: ketoacyl-ACP α acetate- BR48_RS0118695 phosphatase: BR48_RS0111395 D-ala reductase: decarboxylase: lysA glu a (3R)-3-hydroxytetradecanoyl-[acp] decanoyl-CoA -D-ribose 1,5-bisphosphate bisphosphate undecaprenyl- peptide deformylase: leucyl ribonuclease PH: glutathione carbonic anhydrase: BR48_RS0110405 dehydrogenase: amino acid low specificity L- argF stearate biosynthesis preuroporphyrinogen thr glutathioselenol tRNA (N(6)-L- -CoA otsB ala BR48_RS0104875 synthase III: fabH aconitate hydratase PRPP PAPS phosphate glucose aminopeptidase: BR48_RS0107965 synthase: BR48_RS0109330 tartrate lpdA aminotransferase: threonine aldolase: II (bacteria and plants) acyl-CoA threonylcarbamoyladenosine(37) ligase: acs BR48_RS0114510 inositol α, α'-trehalose 3-hydroxyacyl-[acyl- AcnA: acnA threonylcarbamoyl- ribose 1,5-bisphosphate dehydrogenase: a [lipoyl-carrier BR48_RS0103245 lys L-citrulline class II fumarate -C(2))- methylthiotransferase phosphotransferase: peptide deformylase: BR48_RS0102080 gshB monophosphatase: [+ 2 isozymes] α BR48_RS0100260 carrier-protein] AMP synthase: dehydrogenase: adenine phosphoadenylyl- 6 6- -mycolate pro an acetoacetyl-[acp] phosphokinase: phnN MtaB: mtaB BR48_RS0117030 BR48_RS0118700 protein]-N -[(R gly dehydratase FabA: fabA hydratase: fumC BR48_RS0103895 BR48_RS0117920 phosphoribosyltransferase: sulfate reductase: (2S)-2- BR48_RS0106190 a nucleoside BR48_RS0114475 β a palmitoyl-[acp] fumarate cis-aconitate (L-threonylcarbamoyl) two-component alkanesulfonate RNA CO H O 2-hydroxy-3- )-lipoyl]-L-lysine ile -alanine [+ 8 isozymes] PRPP BR48_RS0122855 methylbutanoyl- diphosphate a peptide with 2 2 myo-inositol 3-hydroxyacyl-ACP beta-ketoacyl- aconitate hydratase adenylate hydrogen selenide BR48_RS0107920 AMP a proteinogenic diphosphate ophthalmate oxosuccinate uroporphyrinogen-III monooxygenase a 2-methylsulfanyl-N 6 -L- α-D-glucopyranosyl- UMP CoA an N-terminal dehydratase FabZ: fabZ ACP synthase AcnA: acnA a L-methionylaminoacyl- amino acid tRNA (adenosine(37)-N6)- (2E)-dec-2-enoyl-CoA adenine diphosphate sulfite threonylcarbamoyladenine 37 5'-deoxyadenosine an unsulfurated diphosphoundecaprenol formate L-proline I: fabB uroporphyrinogen met threonylcarbamoyltransferase phosphoribosyltransferase: an alkylsulfonate FMNH in tRNA [sulfur carrier] tRNA a (2E)-tetradec-2-enoyl-[acp] heme a biosynthesis 2 beta-ketoacyl- decarboxylase: complex dimerization enoyl-CoA BR48_RS0122855 RdgB/HAM1 family ACP synthase BR48_RS0108660 subunit type 1 TsaB: tsaB hydratase: non-canonical enoyl-ACP phosphatidylserine and succinate NADP-dependent D-threo-isocitrate urea cycle an [amino-group carrier Carbohydrate Biosynthesis II: fabF protoheme BR48_RS0105860 diphosphate a [2-oxoglutarate- an N 10 - (S)-5-amino-3- 6,8- 6-O-trans- a 3-oxooctadecanoyl- phosphatidylethanolamine coproporphyrinogen III [+ 2 isozymes] purine NTP glyphosate a sulfurated an L-methionyl- acetyl-CoA L-threo-3- aci-nitroethane cadaverine putrescine a phenyl acetate reductase FabI: fabI isocitrate dehydrogenase: 6 DL-allothreonine protein]-C-terminal-γ- methoxy-mycolyl- gly protoheme IX an N -L- enoyl-CoA hydrogen sulfide SAM dehydrogenase Met formyltetrahydrofolate oxohexanoate dihydroxypurine [acp] biosynthesis I ADP-forming succinate- pyrophosphatase: degradation II [sulfur carrier] [initiator tRNA ] phenylserine enoyl-ACP farnesyltransferase: BR48_RS0112765 threonylcarbamoyladenine 37 RdgB/HAM1 family non- E2 protein] N 6 - (L-glutamyl)-L-glutamate xanthine trehalose 6- gluconeogenesis I oxygen-dependent -CoA ligase: sucC sucD hydratase: rdgB arg glycine O-antigen building blocks biosynthesis (E. coli) reductase FabI: fabI 3-oxoacyl- a CDP-diacylglycerol BR48_RS0103715 canonical purine NTP octanoyl-L-lysine dehydrogenase: phosphate Calvin-Benson-Bassham cycle CMP-3-deoxy-D- coproporphyrinogen in tRNA BR48_RS0117195 [+ 2 isozymes] glyphosate nitronate homospermidine acetylglutamate trehalose- phosphatidylcholine/ pyrophosphatase: rdgB 3-keto-5- arylesterase: xdhB xdhA oxidase manno-octulosonate [acyl-carrier- oxidase: hemF ferroheme o glycine methionyl-tRNA serine low specificity L- synthase: kinase: argB phosphatase: UDP-α-D- α-D- a myristoyl-[acp] succinyl-CoA (S)-3- FMNH2-dependent ammonium aminohexanoate monooxygenase: ThiO: thiO (S)-malate D-glucopyranose biosynthesis protein] phosphatidylserine 2-oxoglutarate [+ 2 isozymes] phosphate oxidase lipoyl formyltransferase: hydroxymethyltransferase: threonine aldolase: an [amino-group carrier BR48_RS0108860 xanthine CO galactose glucopyranose hydroxydecanoyl-CoA alkanesulfonate argininosuccinate cleavage protein: BR48_RS0105370 BR48_RS0100330 trehalose-otsB D-ribulose-1,5- 2 6-phosphate D-ribulose reductase: synthase: protoporphyrinogen IX heme A synthase: arginase: synthase: BR48_RS0106195 BR48_RS0116890 BR48_RS0100260 dehydrogenase: glyoxylate UDP- glucose-6-phosphate beta-ketoacyl-ACP ThiO: thiO BR48_RS0100865 protein]-C-terminal- ribulose 1-phosphate 5-phosphate fabG BR48_RS0121815 BR48_RS0117065 3-hydroxyacyl-CoA phosphate monooxygenase: (aminomethyl) lyase: argH glutamine- lipA xdhB xdhA trans-methoxy- malate bisphosphate galactopyranose glucose-1-phosphate isomerase: N-end rule pathway I (prokaryotic) rocF γ-(5-phospho-L- bisphosphate D-arabinose synthase I: fabB protoporphyrinogen dehydrogenase: ssuD phosphonate hydrolyzing [+ 3 isozymes] N-(4-aminobutyl) mono-mycolate dehydrogenase: mutase: glf thymidylyltransferase BR48_RS0107215 [+ 2 isozymes] CDP-diacylglycerol--serine 2-oxoglutarate a [2-oxoglutarate an N-formyl- acetaldehyde nitrite glutamyl)-L-glutamate acetate a phenol urate carboxylase 5-phosphate beta-ketoacyl-ACP oxidase HemJ: hemJ ferroheme i leucyl/phenylalanyl- BR48_RS0118625 assimilatory carbamoyl- -cadaverine UDP-Galf α RfbA: rfbA F6P a (3R)-3- O-phosphatidyltransferase: dehydrogenase L-arginino- 5'-deoxyadenosine dehydrogenase an unsulfurated L-methionyl- a tetrahydrofolate acetaldehyde gly benzaldehyde gly mdh small subunit: dTDP- -D-glucose isomerase: synthase II: fabF tRNA--protein sulfate reduction III L-ornithine phosphate met hydroxyoctadecanoyl- pssA E1 component: 3-oxodecanoyl-CoA 6 [sulfur carrier] [initiator tRNA met ] (S)-3- BR48_RS0100300 a 3-sn-phosphatidyl- protoporphyrin IX heme A synthase: transferase: succinate synthase: E2 protein] N acetoacetate BR48_RS0119830 dTDP- glutamine-- aldehydo-D- [acp] BR48_RS0108970 aminobutanoyl-CoA a 3-oxohexadecanoyl-[acp] L-serine BR48_RS0117065 a [protein] -lipoyl-L-lysine oxaloacetate glucose 4,6- fructose-6- arabinose 5- 3-hydroxyacyl- an N-terminal BR48_RS0111485 3-ketoacyl- sulfate carA carB phosphatidylserine deferrochelatase/ N-terminal L- phosphoribulokinase: dehydratase: phosphate phosphate [acyl-carrier- arginyl-[protein] CoA thiolase: sulfate carbamoyl pyruvate 3-oxoacyl-[acyl-carrier- decarboxylase: peroxidase hydroxyferroheme i leucyl-L-arginine D-ribulose BR48_RS0119850 3-phospho- transaminase protein] BR48_RS0105330 adenylyltransferase: L-cysteine degradation III an L-1- a methylated 34 a thiocarboxylated D-ribulose-1,5- a uridine 38- phosphoenolpyruvate rfbB protein] reductase: fabG EfeB: efeB argininosuccinate ornithine phosphate an L-lysyl- a uridine adenosylcobinamide chitin 5-phosphate ribose-5- D-glycerate BR48_RS0102215 cysN cysD phosphatidyl- 2-oxoglutarate nucleobase [SAMP] C- dihydrolipoamide phenyl acetate a protein a protein D-ala dTDP-4-dehydro- (isomerizing) dehydratase an aldehyde FMN [tRNA Lys ] in tRNA bisphosphate 40 in tRNA carboxykinase: [+ 2 isozymes] ferrochelatase: leucyl/phenylalanyl- octanoyl-CoA APS synthase: carbamoyltransferase: phosphate α : glmS FabA: fabA an L-1- sn-glycerol within DNA terminal glycine bifunctional pyruvate RluA family ATP-dependent BR48_RS0108525 ribulose-phosphate 6-deoxy- -D- D-arabinofuranose BR48_RS0108810 argF glycine isomerase phosphatidylethanolamine BR48_RS0100315 tRNA--protein cys adenosylcobinamide dehydrogenase beta-N- pseudouridine Clp protease endopeptidase La: 3-epimerase: glucopyranose D-glucosamine 5-phosphate a (3R)-3-hydroxyhexadecanoyl-[acp] 3-hydroxyacyl- acyl-CoA phosphoadenylyl- L-citrulline ribulose oxidase RpiA: rpiA phosphoglycerate transferase: bifunctional alpha-ketoglutarate- tRNA 2- kinase/ complex acetylhexosaminidase: synthase: arylesterase: proteolytic subunit: BR48_RS0117235 phosphoenol BR48_RS0119820 dTDP-4- 6-phosphate 3-deoxy-8- ACP protoheme ferroheme a a [protein] dehydrogenase: sulfate reductase: bisphosphate ThiO: thiO D-ribose 5- an N-terminal BR48_RS0111485 lysylphosphatidylglycerol dependent thiouridine(34) adenosylcobinamide- dihydrolipoamide nagZ BR48_RS0110565 BR48_RS0108860 BR48_RS0104125 pyruvate kinase: pgk dehydrorhamnose phosphoglucosamine phosphooctulonate 3-hydroxyacyl-[acyl- dehydratase N-terminal L- BR48_RS0117920 BR48_RS0107920 carboxylase ribulose-phosphate phosphate L-lysyl-[protein] polyphosphate metabolism flippase/synthetase dioxygenase AlkB: synthase phosphate acetyltransferase: [+ 2 isozymes] pyruvate 3,5-epimerase: rfbC mutase: synthase: kdsA carrier-protein] FabZ: fabZ leucyl-L-lysine 38- [+ 2 isozymes] a peptide phosphopyruvate 3-epimerase: transketolase: tkt [+ 8 isozymes] MnmA: mnmA small subunit: guanylyltransferase: BR48_RS0122195 a pseudouridine D-xylulose dehydratase FabA: fabA sulfite MprF: mprF BR48_RS0108540 N-acetyl-D- hydratase: BR48_RS0112620 dTDP-4- BR48_RS0110520 a (2E)-octadec- 3-mercaptopyruvate long chain BR48_RS0119830 cobU 40 in tRNA a peptide 5-phosphate transketolase: tkt 13-DPG (2E)-oct-2-enoyl-CoA S-acetyldihydrolipoamide chitin glucosamine acetate phenol BR48_RS0122215 dehydrorhamnose α-D-glucosamine KDO-8P 3-hydroxyacyl-ACP 2-enoyl-[acp] assimilatory sulfite D-sedoheptulose (Kdo) -lipid A polyphosphate a nucleobase a [SAMP] C- a 2-thiouridine 34 adenosyl-cobinamide 3,5-epimerase: rfbC 1-phosphate dehydratase FabZ: fabZ 2 Respiration reductase (NADPH) 3-O-L-lysyl-1-O- formaldehyde succinate 2-phospho- 7-phosphate enoyl-ACP biosynthesis I (E. coli) 2-oxoglutarate decarboxylation to succinyl-CoA enoyl-CoA Lys within DNA terminal glycine in tRNA 3-phospho- phosphate transketolase: tkt NADH repair (prokaryotes) 3-mercaptopyruvate a tRNA 2-phosphoglycolate D-glycerate dTDP-4-dehydro- bifunctional UDP-N- hydratase: : BR48_RS0107925 phosphatidylglycerol D-glycerate + + a (2E)-hexadec-2-enoyl-[acp] reductase α-Kdo-(2->4)-α-Kdo- sulfurtransferase: Na RS0116930 Na transketolase: tkt β-L-rhamnose acetylglucosamine a [2-oxoglutarate polyphosphate FabI: fabI (2->6)-lipid IV (E. coli) BR48_RS0105860 sseA A dehydrogenase hydrogen sulfide dTDP-4- diphosphorylase/ α-Kdo lipid A biosynthesis NADH kinase 2: ppk2 exopolyphosphatase: ppx enoyl-ACP enoyl-ACP 6 enoyl-CoA D-sedoheptulose dehydrorhamnose glucosamine-1- lauroyl acyltransferase: E2 protein] N [+ 3 isozymes] 2503 a [Co(II) proline an sn-glycero-3- (3R,5S)-3- reductase 2-oxoglutarate hydratase: adenine acetoacetate succinyl-CoA 4-nitrophenyl a ribonucleoside 3-phospho- 1,7-bisphosphate reductase: rfbD reductase FabI: fabI -lipoyl-L-lysine A(H) betaine-specific phospho-N-(acyl) L-threonine 3- hydroxy-1- pro citrate potassium- D-glyceraldehyde phosphate N- 3-deoxy-manno- α α BR48_RS0113335 dehydrogenase BR48_RS0117195 hydrogen sulfide pyruvate in 23S rRNA ATP palmitate diphosphate GTP D-glycerate F6P β enoyl-ACP FabI: fabI -Kdo-(2->4)- -Kdo-(2-> a tRNA precursor ethanolamine O-phosphate + + 3-phosphate dTDP- -L- acetyltransferase octulosonate 2-oxoglutarate E1 component: corrinoid protein] vitamin B12- pyrroline-5- aconitate K transporting K reductase FabI: fabI 6)-(lauroyl)-lipid IV (E. coli) (S)-3- CTP phosphoglycerate class 1 fructose- sedoheptulose rhamnose GlmU: glmU cytidylyltransferase: A dehydrogenase BR48_RS0108970 long chain dependent threonine-phosphate adenylate/guanylate carboxylatepyrroline-5- proline racemase: hydratase ATPase a stearoyl-[acp] myristoyl-acyl carrier hydroxyoctanoyl-CoA 23S rRNA DUF4445 domain- acyl CoA:acetate/ kinase: pgk bisphosphatase: bisphosphate N-acetyl-α-D- BR48_RS0105710 E1 component: polyphosphate glycerophosphodiester arylesterase: ribonucleotide decarboxylase: cyclase domain- carboxylate BR48_RS0107265 AcnA: acnA a palmitoyl-[acp] protein-dependent (R)-NADHX 3-hydroxyacyl-CoA (adenine(2503)-C(2) containing protein: 3-ketoacid CoA BR48_RS0119855 aldolase: triose-phosphate glucosamine BR48_RS0108970 bifunctional CCA tRNA phosphodiesterase: BR48_RS0108860 reductase: BR48_RS0113400 containing protein: reductase: 2+ 2+ CMP-Kdo acyltransferase: dehydrogenase: )-methyltransferase BR48_RS0113605 transferase: (R)-1-amino- D-threo-isocitrate Zn RS0108010 Zn BR48_RS0119840 isomerase: 1-phosphate [+ 3 isozymes] nucleotidyltransferase: BR48_RS0118090 BR48_RS0112255 BR48_RS0115130 BR48_RS0104875 13-DPG class II fructose- BR48_RS0113335 acyl-CoA hydrolysis a [2-oxoglutarate a [2-oxoglutarate ADP-dependent BR48_RS0118625 RlmN: rlmN BR48_RS0107665 a 2'- 2-propanol O D-proline BR48_RS0122250 dehydrogenase dehydrogenase NAD(P)H-hydrate BR48_RS0122920 [+ 12 isozymes] Hyp bisphosphatase: bifunctional UDP-N- α-D-Kdo-(2->4)-α-D- deoxyribonucleoside -2-phosphate 6 6 a [Co(I) proline cyclic-GMP type I glpX acetylglucosamine E2 protein] N E2 protein] N -S- dehydratase/ 3-oxooctanoyl-CoA A 4-nitrophenol palmitate 5'-diphosphate β-D-fructose 1,6- stearate Kdo-(2->6)-lipid A (E. coli) a 2,3,4-saturated 2503 an N- Nucleoside and Nucleotide Degradation a 2-methyladenine betaine-specific a tRNA sn-glycerol glyceraldehyde- DHAP diphosphorylase/ palmitate -dihydrolipoyl- succinyldihydrolipoyl- NAD(P)H-hydrate 5'-deoxyadenosine acetoacetyl-CoA succinate acylethanolamine bisphosphate fatty acyl CoAacyl-CoA 3-ketoacyl- in 23S rRNA met corrinoid protein] 3-phosphate 3-phosphate PRPP biosynthesis glucosamine-1- long-chain-fatty- L-lysine L-lysine epimerase: containing a thioesterase: CoA thiolase: triose-phosphate dehydrogenase: phosphate N- long-chain-fatty- acid--CoA ligase: BR48_RS0112075 purine nucleotides degradation II (aerobic) 3' CCA end D-ribose 5- BR48_RS0115225 (S)-NADHX BR48_RS0105330 superpathway of pyrimidine isomerase: gap acetyltransferase acid--CoA ligase: BR48_RS0107235 phosphate deoxyribonucleosides degradation superpathway of purine deoxyribonucleosides degradation BR48_RS0122250 GlmU: glmU BR48_RS0107235 acyl-CoA [+ 3 isozymes] a 2'- 3 D-glyceraldehyde ribose-phosphate a 2,3,4-saturated 2-oxoglutarate bifunctional hexanoyl-CoA an N-terminal lysine within an N -methyladenine 2251 DHAP fructose- an L-phenylalanyl- isobutanoate canavaninosuccinate guanosine (S)-5-hydroxyisourate roseoflavin L(or D)-O- an aliphatic nitrile 3-phosphate cellulose pyrophosphokinase: prs UDP-N-acetyl- acyl-CoA synthetase: synthetase: fatty acid dehydrogenase ADP-dependent AMP 2'-deoxycytidine an octanoyl-[acp] deoxyribonucleoside bisphosphate arginyl-[protein] [tRNA Phe ] gcv protein H [DNA] in DNA in 23S rRNA ATP biosynthesis α acyl-CoA 5'-triphosphate hydroxyisourate bifunctional phosphoserine aldolase class I: PRPP -D-glucosamine BR48_RS0110440 BR48_RS0110440 E1 component: NAD(P)H-hydrate 23S rRNA nitrile dehydrogenase: pyrimidine 5'- nucleoside 2'-deoxyguanosine hydrolase: uraH riboflavin kinase/ phosphoserine BR48_RS0109965 BR48_RS0108970 dehydratase/ (guanosine(2251) adenylate/guanylate hydratase: cellulose palmitoyl-CoA stearoyl-CoA DNA-3- FAD synthetase: phosphatase trehalose biosynthesis I NAD(P)H-hydrate BR48_RS0117920 nucleotidase: deaminase: 2'-deoxyadenosine leucyl/phenylalanyl- lipoyl(octanoyl) acetate--CoA DNA polymerase argininosuccinate -2'-O)- hydroxyisourate cyclase domain- nthB nthA fructose- fructose- UDP- 2-oxoglutarate methyladenine SerB: serB epimerase: [+ 8 isozymes] BR48_RS0106235 BR48_RS0112265 thymidine tRNA--protein transferase ligase: acs III subunit chi: lyase: argH methyltransferase hydrolase: uraH containing protein: BR48_RS0104475 a primary bisphosphate bisphosphate forming dehydrogenase glycosylase I: (S)-2-oxo-4- roseoflavin D-glucopyranose BR48_RS0112075 [+ 2 isozymes] [+ 3 isozymes] purine-nucleoside transferase: LipB: lipB BR48_RS0102070 RlmB: rlmB BR48_RS0115130 aldolase class I: α aldolase class II: Nucleoside and Nucleotide Biosynthesis complex BR48_RS23795 2-O- hydroxy-4-carboxy- serine aliphatic amide UDP- -D-glucose 6-phosphate cellulose (2E)-hexenoyl-CoA GMP thymidine BR48_RS0111485 5'-phosphate adenosine phosphorylase: [+ 7 isozymes] 2251 [+ 14 isozymes] BR48_RS0109965 BR48_RS0119840 synthase dihydrolipoyllysine- phosphorylase: a [glycine-cleavage methylguanosine 5-ureidoimidazoline NADH adenosine 2'-deoxyuridine deaminase: BR48_RS0107315 isobutanoyl-CoA L-canavanine fumarate cyclic-AMP residue enoyl-CoA deoA complex H protein] diphosphate in 23S rRNA fructose- trehalose-6- catalytic superpathway of pyrimidine pyrimidine 5'- purine-nucleoside acyl-carrier protein AMP an apurinic site 5-aminoimidazole ribonucleotide biosynthesis I pyrimidine deoxyribonucleotides de novo biosynthesis I hydratase: BR48_RS24095 L-phenylalanyl-L- 6 superpathway of inosine-5'-phosphate biosynthesis I xanthine and succinyltransferase: Phe N -octanoyl-L-lysine 3-methyladenine bisphosphate phosphate subunit: ribonucleotides de novo biosynthesis adenosine nucleotidase: phosphorylase: a tRNA within DNA superpathway of guanosine adenosine nucleotides xanthosine salvage odhB BR48_RS0105860 IMP thymine arginyl-[protein] [DNA] aldolase class II: synthase: bcsA deaminase: BR48_RS0106235 BR48_RS0107315 purine-nucleoside nucleotides de novo biosynthesis I de novo biosynthesis I UDP CTP Secondary Metabolite Biosynthesis BR48_RS0119840 α cellulose AIR PRPP enoyl-CoA phosphorylase: BR48_RS25270 UDP- -D-glucose gln hydrogencarbonate vitamin B12-dependent BR48_RS24095 [+ 2 isozymes] IMP 2'-deoxyinosine adenosine hydratase: BR48_RS0107315 biosynthesis xanthosine ribonucleotide reductase: dehydrogenase: nucleotides a 2'- α 46 IMP 5-(carboxyamino)imidazole amidophosphoribosyltransferase: methylerythritol phosphate pathway I BR48_RS0117195 an N-terminal an L-arginyl- 3-(N-morpholino) -D-glucopyranose a [release factor]- a guanine a supercoiled sn-glycerol α,α-trehalose IMP asp BR48_RS0112255 CDP inosine guanosine α an L-phenylalanyl- glutathione deoxyribonucleoside pyruvate purine-nucleoside 2-oxoisovalerate decarboxylation to isobutanoyl-CoA guaB 2-deoxy- -D- degradation III Phe a phytochelatin a protein Arg propanesulfonate CTP 1-phosphate in tRNA repressor LexA D-glucopyranose ribonucleotide synthase: BR48_RS0102200 (S)-3- 2-deoxy-α- L-lysyl-[protein] [tRNA ] [tRNA ] [DNA] L-glutamine duplex DNA 3-phosphate β-D-fructose 1,6- 6-phosphate glutamine- phosphorylase: dUDP vitamin B12-dependent preQ biosynthesis uracil ribose 1-phosphate 5'-triphosphate peptide chain tRNA UvrD-helicase 6-phosphate BR48_RS0110050 5-phospho-β- gly D-glyceraldehyde 0 hydroxyhexanoyl-CoA D-ribose 1- glycerol-3- pyruvate bisphosphate alpha-D-glucose hydrolyzing IMP ribonucleotide reductase: pyruvate an [apo BCAA purine-nucleoside purine-nucleoside release factor (guanosine(46)-N7) domain-containing transcriptional trehalose- adenylosuccinate BR48_RS0107315 nucleoside-diphosphate 3-phosphate XMP phosphopentomutase: AMP phosphate carboxylase: phosphate-specific UDP-α-D-galactofuranose carbamoyl- dehydrogenase: xanthine D-ribosylamine dehydrogenase E2 alpha-ketoacid 3-hydroxyacyl-CoA phosphate FMNH2-dependent glucose-1-phosphate repressor class 1 fructose- phosphatase: N5-CAIR kinase: BR48_RS0102030 BR48_RS0112255 phosphorylase: phosphorylase: leucyl/phenylalanyl- phytochelatin DNA polymerase N(5)-glutamine -methyltransferase protein: dehydrogenase: pyc guaB synthase: 6 dehydrogenase: BR48_RS0105850 arginyltransferase: alkanesulfonate cytidylyltransferase: otsB phosphoglucomutase: biosynthesis phosphate GTP protein] N -lipoyl-L-lysine dehydrogenase BR48_RS0107315 BR48_RS0107315 phosphopentomutase: AMP nucleosidase: tRNA--protein synthase: methyltransferase: TrmB: trmB BR48_RS0114005 LexA: lexA bisphosphatase: BR48_RS0110550 xanthine dCDP 1-deoxy-D-xylulose- pyrimidine 5'- III subunit chi: an N 7 - BR48_RS0107715 BR48_RS0106740 synthase: 5-(carboxyamino)imidazole phosphoribosylamine- dUTP subunit beta: BR48_RS0118625 BR48_RS0105850 2-deoxy-D-ribose BR48_RS0102860 BR48_RS0115320 BR48_RS0116850 monooxygenase: BR48_RS0106470 cleaved oxaloacetate BR48_RS0119855 α-D-glucopyranose α GTP nucleotidase: transferase: BR48_RS0102070 prmC 46 [+ 4 isozymes] α α UDP- -D-glucose phosphoribosyltransferase: -glycine ligase: purD 5-phosphate 5 methylguanine DHAP , -trehalose carA carB XMP ribonucleotide mutase: purE nucleoside triphosphate nucleoside-diphosphate BR48_RS0114655 5-phosphate BR48_RS0111485 ssuD a [release factor]-N a single repressor LexA 1-phosphate synthase: cyclohydrolase 3-oxohexanoyl-CoA hypoxanthine guanine BR48_RS0106235 2-deoxy-D-ribose adenine [+ 9 isozymes] in tRNA class II fructose- UDP-glucose 4- BR48_RS0112240 7,8- α adenylo-succinate pyrophosphohydrolase: kinase: BR48_RS0102030 I FolE: folE 3-methyl-2- 5-phosphate CDP- -D-glucose -methyl-L-glutamine stranded DNA bisphosphatase: UTP--glucose- epimerase GalE: galE glutamine- asp CAIR BR48_RS0103755 [+ 2 isozymes] deoxyribose- an N-terminal carbamoyl GAR mazG dihydroneopterin oxobutanoate acetyl-CoA C- gly a phytochelatin a tRNA Arg 3-(N-morpholino) glpX 1-phosphate asp dCTP L-phenylalanyl- arginyl-[protein] sulfite [+ 2 isozymes] hydrolyzing GMP adenylosuccinate XMP 3'-triphosphate phosphate a tRNA Phe UDP-α-D-galactose phosphate dUTP diphosphatase: 1-deoxy-D-xylulose dehydrogenase (2- acetyltransferase: xanthine guanine xanthosine deoxyribose- L-lysyl-[protein] [DNA] propanal uridylyltransferase synthase: guaA lyase: phosphoribosylglycinamide 6-carboxytetrahydropterin dihydrolipoyl aldolase: deoC F6P phosphoribosylaminoimidazolesuccinocarboxamide BR48_RS0107250 5-phosphate methylpropanoyl- BR48_RS0109860 dehydrogenase: deaminase: phosphate GalU: galU UDP-galactopyranose BR48_RS0112630 CMP phosphorylation formyltransferase: guanine and guanosine salvage dehydrogenase: aspartate synthase: BR48_RS0112655 synthase: transferring): [+ 2 isozymes] xdhB xdhA guaD aldolase: BR48_RS0101955 dUMP glucose-6-phosphate UDP-α-D-glucose mutase: glf GMP BR48_RS0109045 BR48_RS0108990 BR48_RS0117780 carbamoyltransferase phosphoribosylaminoimidazolesuccinocarboxamide CMP an [apo BCAA dehydrogenase xanthine guanine purine-nucleoside deoC acetaldehyde D-glyceraldehyde 3-phosphate 5-methoxy-6- a 3-methyl-branched an N-terminal (1S,2R)-1- an N-terminal L- an [RNA]-3'- guanine 37 a [protein]- isomerase: UDP-Galf AMP thymidylate synthase: 6-carboxy-5,6,7,8- [+ 2 isozymes] BR48_RS0117785 butanoyl-CoA NaMN 2-oxoglutarate an L-arginyl- isethionate histidinol 3-cyanopyridine catalytic subunit: synthase: BR48_RS0104650 FGAR an [apo BCAA 6 2,3,4-saturated 3-sulfino-L- C-(indol-3- alanyl-[S18 protein ribonucleoside- Phe a protein (d)CMP kinase: E2 protein] N -S-[2- dehydrogenase: deaminase: phosphorylase: methylbenzimidazole Arg ser in tRNA L-histidine BR48_RS0107215 BR48_RS0113905 guanosine tetrahydropterin D-glyceraldehyde [tRNA ] BR48_RS0117570 guanylate kinase: BR48_RS0108120 dehydrogenase E2 protein] acyl-CoA xdhB xdhA guaD BR48_RS0107315 fatty acyl-CoA alanyl-[protein] yl)glycerol of 30S ribosome]ribosomal protein 2',3'- tRNA histidinol histidine kinase: nitrile D-glucopyranose purine-nucleoside MEP 6 methylpropanoyl]dihydrolipoyl- acetaldehyde CDP phosphoribosylformylglycinamidine dTMP 7-carboxy-7- N -dihydrolipoyl-L-lysine 3-phosphate 3-phosphate cyclophosphate (guanosine(37)-N1) dehydrogenase: hisD BR48_RS0102115 adenylate kinase: L-lysine dehydrogenase: nicotinate-nucleotide-- S18-alanine N- RNA 2',3'-cyclic BR48_RS0121585 metalloprotease hydratase: 6-phosphate SAICAR synthase: purS purQ phosphorylase: deazaguanine phytanoyl-CoA FMNH2-dependent -methyltransferase N-carbamoyl- BR48_RS0121410 nucleoside- dTMP kinase: bifunctional 2-C- BR48_RS0117920 acetyltransferase: histidinol [+ 2 isozymes] TldD: tldD nthB nthA phosphoribosylformylglycinamidine BR48_RS0107315 xanthine acetyl-CoA purine ribonucleosides degradation dimethylbenzimidazole dioxygenase: arginyltransferase: tryptophan alkanesulfonate phosphodiesterase: synthase: queE 1 TrmD: trmD dehydrogenase: hisD a [protein]- L-aspartate adenylosuccinate lyase: diphosphate kinase: BR48_RS0122015 guanine methyl-D-erythritol [+ 8 isozymes] phosphoribosyltransferase: an N-terminal N-acetyl-rimI thpR an N - GDP synthase subunit PurL: purL BR48_RS0120640 BR48_RS0116850 synthase: trpB monooxygenase: an [RNA]-3'- N-phospho- nicotinamide BR48_RS0112630 BR48_RS0102030 4-phosphate 7-carboxy-7- xanthine cobT ssuD L-alanyl-[S18 protein methylguanine 37 his a peptide dihydroorotase: ADP dTDP crotonyl-CoA BR48_RS0108445 ribunucleoside- L-histidine deazaguanine acetyl-CoA of 30S ribosome] Phe BR48_RS0117565 CTP FGAM xanthine cytidylyltransferase/ dehydrogenase adenosine a 2-hydroxy-3-methyl- 2'-phosphate in tRNA AICAR nucleoside-diphosphate an N-terminal L- phosphoribosyltransferase: 2-C-methyl-D- 2-oxo acid enoyl-CoA accessory protein 5-methoxy-6- branched 2,3,4- succinate D-glyceraldehyde dihydroorotase: nucleoside- vitamin B12- vitamin B12- kinase: BR48_RS0102030 a tRNA Arg arginiyl-3-sulfino- phosphoribosylformylglycinamidine BR48_RS0112240 erythritol 2,4- dehydrogenase hydratase: XdhC: xdhC nicotinate 3-phosphate trp glycolaldehyde sulfite BR48_RS0102325 diphosphate kinase: dependent dependent bifunctional adenosine methylbenzimidazole saturated fatty acyl-CoA L-alanyl-[protein] cyclo-ligase: BR48_RS0101950 dTTP hypoxanthine cyclodiphosphate subunit E2: BR48_RS0105860 [+ 3 isozymes] Amine and Polyamine Biosynthesis BR48_RS0102030 ribonucleotide ribonucleotide phosphoribosylaminoimidazolecarboxamide deaminase: ribotide phosphate (S)-dihydroorotate synthase: preQ BR48_RS0117790 reductase: formyltransferase/IMP cyclohydrolase: purH phosphoribosyltransferase: hpt 0 enoyl-CoA UTP and CTP dephosphorylation I BR48_RS24095 reductase: superpathway of pyrimidine deoxyribonucleoside salvage AIR BR48_RS0122150 urate BR48_RS0112255 hydratase: spermidine BR48_RS0112255 an N-terminal 1402 37 34 6-O-cis-methoxy- phosphoenol putrescine quinone-dependent FAICAR GMP 4-(cytidine 5'- 5-methoxybenzimidazole NaMN an L-arginyl- O-succinyl-L- (S)-2- a cytidine α-L-rhamnopyranose a guanine a cytidine biosynthesis I putrescine homospermidine GTP Pentose Phosphate Pathways BR48_RS0117195 UTP xanthosine adenosine inosine guanosine a proteinogenic leukotriene-C4 3-sulfo-L- glu D-glycerate mycolyl-trehalose biosynthesis I dihydroorotate 2'-deoxycytidine diphospho)-2-C- [tRNA Arg ] homoserine aminobutanoate in 16S rRNA in tRNA in tRNA pyruvate biosynthesis III biosynthesis I amino acid L-rhamnose tRNA (cytidine(34) 6-phosphate dADP bifunctional methyl-D-erythritol NADPH repair (prokaryotes) (S)-3- alanyl-[protein] 16S rRNA tRNA 2-hydroxy-3- dehydrogenase: CTP synthase: mutarotase: trehalose- pyruvate SAM dGDP phosphoribosylaminoimidazolecarboxamide nucleoside adenine and adenosine salvage III superpathway of pyrimidine 4-(cytidine 5'- pentose phosphate pathway hydroxybutanoyl-CoA (cytidine(1402)-2'-O) (guanosine(37)-N1) -2'-O)- oxopropionate arg putrescine spermidine BR48_RS0105200 myo-inositol BR48_RS0122235 nicotinate-nucleotide-- BR48_RS0100570 phosphatase: arg nucleoside- formyltransferase/IMP cyclohydrolase: purH nucleobases salvage (non-oxidative branch) II 3-hydroxyacyl-CoA thymine degradation purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside O-succinylhomoserine glutamate-- -methyltransferase: -methyltransferase methyltransferase: reductase: kinase: pyk PRPP deaminase: diphospho)- biosynthesis NADPH dimethylbenzimidazole gamma- arginyltransferase: otsB orotate diphosphate kinase: UDP phosphorylase: phosphorylase: phosphorylase: phosphorylase: rsmI L-rhamnose TrmD: trmD BR48_RS0122890 BR48_RS0119460 arginase: nucleoside- BR48_RS0112265 uracil 2-C-methyl-D- dehydrogenase: sulfhydrylase: cysteine ligase: an N 1 - trehalose- dCMP D-ribulose thymine CTP phosphoribosyltransferase: glutamyltransferase: ggt BR48_RS0116850 a 2'-O- a 2'-O- tartronate pyruvate homospermidine BR48_RS0102030 D-glucopyranose BR48_RS0118625 BR48_RS0107315 BR48_RS0107315 BR48_RS0107315 BR48_RS0107315 1402 mutarotase: rhaM 37 34 rocF homospermidine diphosphate kinase: IMP [+ 3 isozymes] adenine uracil erythritol kinase: 5-phosphate BR48_RS0105245 BR48_RS0104640 methylcytidine methylguanine methylcytidine cis-methoxy- orotate (d)CMP kinase: guanine and guanosine salvage II cobT semialdehyde agmatine synthase: biosynthesis II BR48_RS0102030 BR48_RS0103950 6-phosphate β-L-rhamnopyranose in tRNA mono-mycolate L-ornithine purine-nucleoside phosphoribosyltransferase: acetoacetyl-CoA α-D-ribose- in 16S rRNA in tRNA putrescine dAdoMet BR48_RS0100330 phosphoribosyltransferase: dATP BR48_RS0108120 2-phospho-4-(cytidine α γ an N-terminal L- agmatinase: 2'-deoxyuridine phosphorylase: BR48_RS0107305 ribose-5- ribulose-phosphate 5,6-dihydrothymine UMP an -( -L-glutamyl) γ-L-glutamyl-(S)- BR48_RS0102460 1-phosphate leukotriene-D4 a tRNA Arg arginiyl-3-sulfo- succinate ornithine putrescine dGTP dCDP BR48_RS0107315 UMP 5'-diphospho)-2-C- phosphate 3-epimerase: acetyl-CoA C- CDP 5-methoxybenzimidazole nicotinate -L-amino acid L-homocysteine speB guanosine Ins(3)P (R)-NADPHX pyrimidine deoxyribonucleotides 2-aminobutanoate decarboxylase: sym- homospermidine thymidine kinase: adenosine methyl-D-erythritol bifunctional dihydropyrimidinase: pyrimidine 5'- phosphopentomutase: pseudouridine ribotide phosphate L-alanyl-[protein] spermidine agmatinase: nucleoside- UMP kinase: isomerase BR48_RS0119820 acetyltransferase: dephosphorylation homospermidine synthase: orotidine 5'- bifunctional 2-C- ADP-dependent hydA nucleotidase: BR48_RS0105850 degradation BR48_RS0114255 BR48_RS0123085 BR48_RS0118115 RpiA: rpiA ribulose-phosphate BR48_RS0105330 synthase: speB BR48_RS0100330 phosphate adenine salvage diphosphate kinase: methyl-D-erythritol inositol BR48_RS0106235 nucleoside triphosphate sym- thymidine adenosine NAD(P)H-hydrate [+ 2 isozymes] 3-(carbamoylamino)- D-ribose 5- BR48_RS0112430 BR48_RS0102030 monophosphatase: 3-epimerase: pyrophosphohydrolase: 1402 1498 6-O-trans-keto- putrescine dUMP deaminase: UDP 4-phosphate dehydratase/ CMP [+ 2 isozymes] pseudouridine a 2-oxo a [DNA]-3'- a cytidine a uracil putrescine homospermidine guanine D-ribose 5- BR48_RS0112620 2-methylpropanoate phosphate 5-hydroxybenzimidazole NaMN coenzyme A an apo [peptidyl- 2-oxoglutarate [DNA] a uridine in tRNA propionitrile orotidine-5'- cytidylyltransferase/ BR48_RS0110405 mazG pseudouridine L-ornithine D-ala hydroxyl in 16S rRNA L-homoserine mycolyl-trehalose dCTP BR48_RS24095 nucleoside-diphosphate NAD(P)H-hydrate phosphate acetyl-CoA pyrimidine 5'- uridine dCTP dCMP carboxylate in 16S rRNA phosphate adenine and adenine thymidylate thymidine kinase: kinase: carrier protein] 16S rRNA DNA polymerase 16S rRNA tRNA 6-phosphate spermidine kinase: BR48_RS0102030 2-C-methyl-D- inositol epimerase: nucleotidase: nitrile decarboxylase: adenosine salvage I BR48_RS0123085 xanthine D-xylulose BR48_RS0112785 III subunit chi: homoserine O- trehalose- synthase: erythritol 2,4- monophosphatase: BR48_RS0112075 (cytosine(1402)-N(4) (uracil(1498)-N(3))- dihydrouridine hydratase: inosine phosphoribosyltransferase: 5-phosphate BR48_RS0106235 pseudouridine nicotinate-nucleotide-- exodeoxyribonuclease succinyltransferase: phosphatase: pyrF BR48_RS0113905 UTP cyclodiphosphate BR48_RS0114475 nucleoside triphosphate ornithine--oxo-acid D-amino-acid )-methyltransferase BR48_RS0102070 methyltransferase: synthase nthB nthA (S)-NADPHX (R)-3-amino-2- [+ 2 isozymes] 5'-phosphate holo-ACP synthase: III: BR48_RS0109135 otsB BR48_RS0112240 pyrophosphohydrolase: S-methyl-5'-thioadenosine dimethylbenzimidazole transaminase: RsmH: rsmH [+ 2 isozymes] BR48_RS0115575 BR48_RS0104635 DusB: dusB UMP adenosine adenine deaminase: ade adenine purine-nucleoside CTP synthase: synthase: transketolase: tkt methylpropanoate BR48_RS0102450 transaminase: an N 4 - a 2'- an N 3 - trehalose- hypoxanthine myo-inositol cytidine mazG degradation IV phosphoribosyltransferase: BR48_RS0117970 [+ 2 isozymes] O-succinyl-L- a 5,6-dihydrouridine propionamide purine-nucleoside phosphoribosyltransferase: phosphorylase: BR48_RS0122235 BR48_RS0122150 bifunctional transketolase: tkt pseudouridine- BR48_RS0122065 methylcytidine 1402 deoxyribonucleoside methyluracil 1498 trans-keto- UMP kinase: adenine and phosphoribosyltransferase: hpt cobT homoserine in tRNA phosphorylase: BR48_RS0122855 BR48_RS0107315 CTP ADP-dependent dUTP diphosphatase: S-methyl-5'- 5'-phosphate in 16S rRNA 5'-monophosphate in 16S rRNA mono-mycolate BR48_RS0118115 adenosine salvage VI 2-C-methyl-D-erythritol- D-sedoheptulose a holo [peptidyl- a 2'- BR48_RS0107315 dTMP NAD(P)H-hydrate BR48_RS0107250 thioadenosine glycosidase: 3',5'-ADP a proteinogenic L-glutamate-5- a [DNA]-3'- hypoxanthine GMP 2,4-cyclodiphosphate 7-phosphate dUMP 5'-methylthioadenosine/ deoxyribonucleoside UDP adenine dehydratase/ dUTP BR48_RS0112790 5-hydroxybenzimidazole carrier protein] amino acid semialdehyde pyruvate hydroxyl dTMP kinase: hypoxanthine diphosphate--fructose- S-adenosylhomocysteine nicotinate D-glt 5'-monophosphate flavodoxin- NAD(P)H-hydrate ribotide phosphate nucleoside- xanthine AMP BR48_RS0122015 adenosine 6-phosphate 1- nucleosidase: uracil adenine xanthine dependent epimerase: diphosphate kinase: phosphoribosyltransferase: dTDP phosphotransferase: 5-hydroxy-CTP 5-hydroxy-CMP BR48_RS0104175 phosphoribosyltransferase: adenosine kinase: (E)-4-hydroxy- BR48_RS0112075 BR48_RS0102030 BR48_RS0112240 phosphoribosyltransferase: MTR BR48_RS0115860 a mature peptidoglycan (meso an apo-[LYS2 L- 2030 a 5,6- (2Z,4E)-2- gln BR48_RS0122855 nucleoside- BR48_RS0107985 BR48_RS0112240 3-methylbut- an (S)-2- adenine coenzyme A hydrogen selenide methyl red a holo [PedN acyl- 20 n-butyronitrile UTP hypoxanthine NADPH D-sedoheptulose Secondary Metabolite Degradation -diaminopimelate containing) 2-aminoadipyl- O-acetyl-L-serine halocarboxylate in 23S rRNA dihydrouracil Hyp hydroxyhexa- ser diphosphate kinase: AMP 2-enyl- carrier protein] phosphoribosyltransferase: hpt hypoxanthine 1,7-bisphosphate carrier-protein] 23S rRNA in tRNA 2,4-dienedioate AMP BR48_RS0102030 diphosphate tRNA threonine/serine nitrile CTP synthase: phosphoribosyltransferase: hpt (adenine(2030)-N(6) ACP S- 4-hydroxyproline 4-oxalocrotonate synthase: ispG sedoheptulose anhydromuropeptides recycling I lytic transglycosylase haloacid FMN-dependent dihydrouridine(20/ tautomerase: dehydratase: hydratase: BR48_RS0122235 IMP dTTP myo-inositol degradation I D-galacturonate D-sorbitol degradation I cysteine )-methyltransferase malonyltransferase: epimerase: (E)-4-hydroxy-3- bisphosphate F: BR48_RS24500 holo-ACP synthase: dehalogenase type NADH-azoreductase: 20a) synthase BR48_RS23420 BR48_RS0120320 nthB nthA IMP GlcNAc-1,6- degradation I synthase RlmJ: rlmJ fabD BR48_RS0109755 methylbut-2-en- aldolase: [+ 9 isozymes] BR48_RS0102450 II: BR48_RS0101090 BR48_RS0105130 an N 6 - a malonyl[PedN DusA: dusA (3E)-2-oxohex- [+ 2 isozymes] CTP anhMurNAc- D-sorbitol A: cysK (4R)-4-hydroxy- butyramide 1-yl diphosphate BR48_RS0119840 myo-inositol aldehydo-D- methyladenine 2030 acyl-carrier a uracil 20 in tRNA L-Ala-γ-D-Glu- L-iditol 2- [+ 3 isozymes] D-proline 3-enedioate pyruvate D-erythrose galacturonate a holo-[LYS2 L- in 23S rRNA protein] DAP-D-Ala inositol 2- glucuronate dehydrogenase: a mature peptidoglycan a mature peptidoglycan strand anthranilate N,N-dimethyl-1,4- 4-hydroxy- 4-phosphate isomerase: with (L-alanyl-γ-D-glutamyl- (non-reducing terminus) 3',5'-ADP 2-aminoadipyl- acetate L-selenocysteine dehydrogenase: BR48_RS0107115 a (2R)-2- phenylenediamine 3-methylbut- transketolase: tkt 1,6-anhydro-N- uxaC meso-2,6-diaminopimeloyl- carrier-protein] a halide anion iolG keto-D-fructose hydroxy fatty acid Cofactor, Carrier, and Vitamin Biosynthesis 2-enyl transketolase: tkt acetylmuramoyl-L- D-tagaturonate Carbohydrate Degradation D-alanine) tetrapeptide 4-hydroxy- diphosphate alanine amidase: scyllo-inosose D-glyceraldehyde pentose phosphate tagaturonate 3-methylbut- reductase: pathway (oxidative branch) I BR48_RS0114200 (S)-2-oxo-4- cob(II)yrinate a,c- [2Fe-2S] iron-sulfur flavin biosynthesis I (bacteria and plants) menaquinol-7 biosynthesis 3-phosphate reductase: Entner-Doudoroff pathway I a nascent peptidoglycan 3-aci- a [protein]-L- cob(II)yrinate a,c-diamide ubiquinol-8 biosynthesis NAD salvage glutathione- superpathway of pyridoxal 5'-phosphate biosynthesis and salvage NAD guanylyl molybdenum adenosylcobalamin 2-enyl ispH myo-inosose-2 a proteinogenic glutathione a 3-oxoacid succinyl-CoA a uracil in DNA a holo [PedD acyl- a D-hexose long chain D-ribofuranose diamide biosynthesis I β D-galactose degradation I (Leloir pathway) (meso-DAP containing) nitropropanoate hydroxy-4-carboxy- proline (ω = 180) thr biosynthesis II (late cluster biosynthesis pathway III (to peroxide phosphorylation and cofactor biosynthesis salvage from cobalamin diphosphate β γ dehydratase: iolE BR48_RS0108260 -D-fructofuranose amino acid carrier protein] polyphosphate (early cobalt insertion) (early decarboxylation) all-trans- D-glucopyranose 6-phosphate N-acetyl- -D- L-alanyl- -D- D-glucopyranose 5-ureidoimidazoline peptidylprolyl cobalt incorporation) nicotinamide riboside) redox reactions D-erythrose transhydrogenation MoO - reductase: glucosamine-1,6- glutamyl-meso-2,6- 3D-(3,5/4)- 2-oxo-4-hydroxy- ACP S- threonine/serine glucokinase: polyphosphate ribokinase: all-trans- heptaprenyl 1,4-dihydroxy- 2 glucose-6-phosphate D-altronate 6-phosphate β-D-galactopyranose isomerase: uroporphyrinogen-III GTP + 4-phosphate cob(I)alamin ispH lytic transglycosylase nitronate uracil-DNA 4-carboxy-5- dehydratase: BR48_RS0108180 kinase 2: ppk2 L-cysteine desulfurase NADP + molybdopterin IPP dehydrogenase: zwf anhydro-N-acetyl- diaminopimeloyl- trihydroxycyclohexane- acyl CoA:acetate/ malonyltransferase: BR48_RS0121670 rbsK uroporphyrinogen-III uroporphyrinogen-III 4-hydroxybenzoate octaprenyl GSSG diphosphate 2-naphthoate NAD cofactor glycolysis III (from glucose) Glycolysis β-D-muramate D-alanine 1,2-dione altronate glucose-6- F: BR48_RS24500 monooxygenase: 3-ketoacid CoA glycosylase: ureidoimidazoline fabD BR48_RS0120320 [+ 2 isozymes] uroporphyrinogen-III diphosphate D-erythrose- NAD kinase: molybdenum cofactor glucose-6-phosphate galactose gamma- [+ 4 isozymes] D-ribofuranose C-methyltransferase: cysteine GTP dehydratase: phosphate [+ 8 isozymes] BR48_RS0105370 transferase: BR48_RS0102485 decarboxylase: uraD a malonyl- [+ 2 isozymes] D-hexose 6- C-methyltransferase: 4-phosphate BR48_RS0111335 guanylyltransferase dehydrogenase: zwf beta-N- 3D-(3,5/4)- F6P mutarotase: glutamyltransferase: ggt a [protein]-L- long chain 5-phosphate cobA desulfurase: cyclohydrolase BR48_RS0108235 dehydrogenase: (S)-(+)-allantoin [PedD acyl- ω phosphate 4-hydroxybenzoate + dehydrogenase: + MobA: mobA cob(II)alamin D-glucopyranose acetylhexosaminidase: trihydroxycyclohexane- BR48_RS0113295 BR48_RS0107665 proline ( = 0) 2-oxobutanoate polyphosphate cobA NAD glutathione- NADP 6-phospho D-glucono-1,5-lactone uroporphyrinogen-III sufS II: ribB 2-dehydro- zwf a mature peptidoglycan a nascent peptidoglycan [unspecified carrier protein] octaprenyltransferase: 2,5-diamino-6- gap molybdopterin- nagZ L-alanyl-γ-D- 1,2-dione acylhydrolase galactose an apyrimidinic uracil C-methyltransferase: uroporphyrinogen-III disulfide cob(I)yrinic acid glucokinase: 3-deoxy-D- glucose-6- with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) an α-(γ-L-glutamyl) 3-oxopropanoate nitrite cysteine desulfurase: BR48_RS0103880 NAD(+) 4-phospho- demethylmenaquinol-7 NAD(P) guanine 6-phosphogluconolactonase: 1,6-anhydro-N- (decyclizing): iolD L-cysteinylglycine degradation site in DNA C-methyltransferase: (5-phospho-D- reductase: DMAPP BR48_RS0108180 glutamyl-meso- gluconate mutarotase: -L-amino acid a 2,3,4-saturated cobA BR48_RS0111395 diphosphatase: D-erythronate a,c-diamide pgl β phosphate meso-2,6-diaminopimeloyl- with GlcNAc terminus products] succinate cobA ribosylamino) gor transhydrogenase dinucleotide acetyl- -muramate diaminopimelate 2-dehydro-3- BR48_RS0121285 heparin degradation 3-oxoacyl-CoA precorrin-1 4-hydroxy-3- nudC bifunctional adenosyltransferase: D-glucopyranose 5-deoxy-D-glucuronate dehydrogenase: D-alanine) tetrapeptide precorrin-1 an S-sulfanyl-[L- pyrimidin- subunit alpha: biosynthesis anhydro-N- deoxygluconokinase: demethylmenaquinone cobO 6-phosphate D-gluconate 6-phosphate zwf α-D-galactopyranose cysteine desulfurase] octaprenylbenzoate 4(3H)-one BR48_RS0100105 guanylylprotein B: mobB 5-deoxy- uroporphyrinogen-III NMN methyltransferase/2- acetylmuramic BR48_RS0113290 6-phospho heparin cob(I)yrinic acid UDP-N-acetyl- 34 an N-acetyl-β- C-methyltransferase: uroporphyrinogen-III bifunctional molybdenum glucose-6-phosphate decarboxylating 6- acid kinase: glucuronate decaprenyl-diphospho-N- a [protein]-S- a uridine a ribonucleoside UDP glutathione (3R)-3-hydroxy-2-oxo- methoxy-6-polyprenyl- NADPH D-glucono- coenzyme A an apo-[aryl- a holo [BryU acyl- 3-aminopropanal propionamide D-glucopyranose C-methyltransferase: cofactor a,c-diamide isomerase: isomerase: iolB KDGP α-D-glucosamine acetylmuramoyl-pentapeptide coenzyme A VibB sulfanyl-L-cysteine in tRNA D-hexosaminide ethylphosphate cobA diaminohydroxyphosphoribosylaminopyrimidine 5'-nucleotidase: 4 phosphooxybutanoate 1,4-benzoquinol phosphogluconate BR48_RS0111405 heparinase: carrier protein] carrier protein] 5'-monophosphate vitamin B12- cobA adenosyltransferase: BR48_RS0107215 1,5-lactone uroporphyrinogen-III deaminase/5-amino-6-(5-phosphoribosylamino) BR48_RS0116480 dehydrogenase: gnd N-acetyl-D- superpathway of β-D- 5-dehydro-2- BR48_RS0109380 alkaline phosphatase: 5'-nucleotidase: betaine-aldehyde amidase: dependent xylose phosphoserine methylase UbiE: ubiE BR48_RS0111045 6-phosphogluconolactonase: α-D-galactose ACP S- uroporphyrinogen-III an S-sulfanyl-[cysteine 2-octaprenylphenol uracil reductase RibD: ribD β muramate 6- deoxy-D-gluconate 2-dehydro-3-deoxy- UDP-α-D-glucose undecaprenyldiphospho- beta-N- BR48_RS0109290 dehydrogenase: BR48_RS0115470 isomerase: C-methyltransferase: 1-( -D transaminase: F6P NADP-dependent glucuronosides degradation 1-phosphate 4-deoxy-2-O-sulfo- tRNA 2- malonyltransferase: BR48_RS0116480 ribonucleotide desulfurase]-[disordered- 5-amino-6-(5- cob(II)alamin- phosphate phosphogluconate pgl muramoylpentapeptide beta-N- betB xylA cobA C-methyltransferase: ribofuranosyl) BR48_RS0110530 menaquinol-7 phosphogluconate 5-dehydro-2- β-L-erythro-hex-4- holo-ACP synthase: holo-ACP synthase: thiouridine(34) acetylhexosaminidase: alkaline phosphatase: [+ 2 isozymes] [+ 2 isozymes] reductase: form scaffold 2-polyprenylphenol phospho-D- [corrinoid β aldolase: acetylglucosaminyltransferase: fabD cobA nicotinamide N-acetylmuramic a -D-glucuronoside deoxygluconokinase: D-gluconate enopyranuronosyl- BR48_RS0102450 BR48_RS0102450 nagZ BR48_RS0110010 a malonyl- BR48_RS0112255 keto-D-fructose 4-phosphooxy- adenosyltranferase] dehydrogenase: gndA synthase a ribonucleoside β-alanine propanoate precorrin-2 protein] complex 6-hydroxylase: ubiB ribosylamino)uracil acid 6-phosphate iolC BR48_RS0100350 6-phosphate murG [BryU acyl- precorrin-2 L-threonine (1,4)-D-N- MnmA: mnmA ethanol dUDP 3-(all-trans D-ribulose bifunctional D-ribulose 5-phosphate etherase: β 5-dehydro-2-deoxy-D- phosphogluconate sulfoglucosamine an N-acetyl-β- carrier protein] -octaprenyl) 5-phosphate diaminohydroxyphosphoribosylaminopyrimidine 4-hydroxythreonine- -D-fructose 1,6- BR48_RS0114390 pyruvate a holo-[aryl- a holo-[VibB aryl- precorrin-2 C(20)- D-glyceraldehyde gluconate 6-phosphate dehydratase: 6-O-sulfate decaprenyl-pyrophosphoryl- UDP 3',5'-ADP 3',5'-ADP an alcohol D-hexosamine benzene-1,2-diol deaminase/5-amino-6-(5-phosphoribosylamino) pyruvate 4-phosphate cob(I)alamin- bisphosphate N-acetyl-D- carrier protein] carrier protein] a [protein]- a 2-thiouridine 34 methyltransferase: a [cysteine desulfurase]- 3,4- 3-phosphate D-glucopyranuronate BR48_RS0104845 (N-acetylglucosamine)-N- bifunctional 2- uracil reductase RibD: ribD dehydrogenase: glucosamine L-cysteine in tRNA BR48_RS0110620 S-sulfanyl-[disordered- dihydroxy-2- [corrinoid acetylmuramyl-(pentapeptide) sirohydrochlorin polyprenyl-6- 5-amino-6-(5- BR48_RS0118690 fructose- 6-phosphate form scaffold butanone-4- 1-deoxy-D-xylulose- adenosyltranferase] KDGP hydroxyphenol phospho-D- bisphosphate N-acetylglucosamine- 4-deoxy-β-L- precorrin-3A protein] complex phosphate 5-phosphate 4-hydroxythreonine- cob(I)yrinic acid cysteine methylase/3- ribitylamino)uracil aldolase class I: 6-phosphate D-galactonate degradation erythro-hex-4- a [glycine-cleavage a single- S-(2-hydroxyacyl) a negatively dCDP 4-phosphate a,c-diamide DHAP 3-oxopropanoate UDP-glucose AsbD acyl- a protein with glutathione hydantoin a holo [BryP acyl- methylglyoxal synthase: synthase: BR48_RS0109965 a sulfurated [sulfur carrier] SAM complex H protein] coenzyme A an acyl phosphate precorrin- desulfurase: demethylubiquinol 3- dehydrogenase adenosyltransferase: deacetylase: nagA aldehydo-D-glucuronate 2-dehydro-3-deoxy- 4-epimerase enopyranuronosyl- stranded RNA glutathione supercoiled DNA vitamin B12- ribB BR48_RS0103755 N 6 -octanoyl-L-lysine carrier protein a disulfide bond carrier protein] 3B sufS O-methyltransferase cobO phosphogluconate GalE: galE (1,4)-D-N- DNA glyoxalase: cobalt- 1-deoxy-L- PdxA: pdxA fructose- D-glucosamine D-galactonate dihydropyrimidinase: ACP S- dependent synthase: glucuronate acylphosphatase: topoisomerase sirohydrochlorin cysteine desulfurase: UbiG: ubiG 1-deoxy-D- 3-amino-1- bisphosphate 6-phosphate aldolase: α [+ 2 isozymes] sulfoglucosamine BR48_RS0110720 ribonucleotide glycero-tetrulose cob(I)yrinic acid isomerase: -D-glucopyranose polyribonucleotide hydroxyacylglutathione hydA malonyltransferase: IV subunit A: parC cobG 2-methoxy- ARP pyridoxine hydroxyacetone superpathway of thiamine diphosphate biosynthesis II D-galactonate BR48_RS0100350 UDP-α-D-galactose 6-O-sulfate BR48_RS23765 [+ 5 isozymes] reductase: BR48_RS0111395 4-phosphate xylulose 5- a,c-diamide aldolase class II: phosphoglucosamine uxaC 1-phosphate lipoyl holo-ACP synthase: glutaredoxin fabD an S-sulfanyl-[cysteine 6-(all-trans- dehydratase: nucleotidyltransferase: pnp hydrolase: gloB [+ 2 isozymes] phosphate 1-phosphate adenosyltransferase: BR48_RS0119840 mutase: acetyl-CoA synthase: lipA BR48_RS0102450 3: grxC a malonyl- (R)-lactate BR48_RS0112255 precorrin-3B desulfurase]-S- octaprenyl)phenol pyridoxamine BR48_RS0122645 D-glyceraldehyde N-carbamoylglycine a carboxylate a relaxed DNA 6,7-dimethyl-8- superpathway of adenosylcobalamin salvage from cobinamide I BR48_RS0111045 BR48_RS0110520 D-fructuronate alpha-D-glucose [BryP acyl- CDP sulfanyl-[disordered- pyridoxal cys 3-phosphate pyruvate cobalt-factor III precorrin-3B C(17)- ribityllumazine pyridoxine 5'- adenosylcob(III) α-D-glucosamine 2-dehydro-3-deoxy- phosphate-specific carrier protein] form scaffold kinase pyridoxal triose-phosphate a [glycine-cleavage a holo-[AsbD acyl- a nucleoside a single- a 2-hydroxy methyltransferase: phosphate synthase: alamin-[corrinoid D-galactonate type I phosphoglucomutase: 4-deoxy-L- N,6-O-disulfo- 3',5'-ADP a protein with glutathione synthase: kinase 1-phosphate 5'-deoxyadenosine 6 an unsulfurated stranded RNA GSSG carboxylate protein] complex cob(II)inamide PdxY: cysteine a [ThiS sulfur- isomerase: threo-hex-4- met complex H protein] N carrier protein] diphosphate reduced L- cobJ 2-methoxy-6-all BR48_RS0116910 BR48_RS0113820 PdxY: adenosyltranferase] 2-dehydro-3- glyceraldehyde- BR48_RS0106740 D-glucosamine [sulfur carrier] pdxY desulfurase: carrier protein] BR48_RS0122250D-glyceraldehyde bifunctional UDP-N- enopyranuronate -[(R)-lipoyl]-L-lysine cysteine residues trans-octaprenyl- cob(I)yrinic acid a,c-diamide pdxY cob(I)yrinic acid 4-deoxy-L-threo-hex-4- deoxygalactonokinase: 3-phosphate precorrin-4 6,7-dimethyl-8- sufS DHAP acetylglucosamine D-mannonate D-glucopyranose 1,4-benzoquinol adenosyltransferase: cobO a,c-diamide 3-phosphate enopyranuronate degradation BR48_RS0116120 dehydrogenase: ribityllumazine pyridoxine pyridoxamine diphosphorylase/ 6-phosphate cobalt-precorrin-3 a [cysteine cysteine desulfurase: type I mannonate 2-dehydro-3-deoxy- gap precorrin-4 C(11)- bifunctional synthase: cob(I)yrinic acid a,c-diamide adenosyltransferase: 4-deoxy-L-threo-hex- a [pyruvate dehydrogenase E2 adenine 1518 / a guanine 527 5'-phosphate 5'-phosphate BR48_RS0111395 glucosamine-1- D-galactonate N-sulfo-D- coenzyme A [EntB aryl- 2-oxoglutarate phytanoyl-CoA a peptide with a acetoacetyl-CoA α-D-lyxopyranose pyrazinamide DNA with lesion desulfurase]-(S- glyceraldehyde- dehydratase: a sulfurated [sulfur carrier] SAM 6 1519 gly methyltransferase: demethylmenaquinone BR48_RS0105755 adenosyltransferase: an [L-cysteine a carboxy- cobO phosphate N- 4-enopyranuronate fucose degradation protein] N -octanoyl-L-lysine adenine in 16S rRNA in 16S rRNA sulfanyl) -[disordered- 3-phosphate uxuA 6-phosphate 13-DPG glucosamine carrier protein] penultimate glycine D-lyxose/D- excinuclease 2 methyltransferase/2- BR48_RS0111045 cob(I)yrinic acid 16S rRNA 3-hydroxybutyryl- 16S rRNA amidase: cobM pyridoxamine 5'- pyridoxal desulfurase]-S- adenylated-[ThiS acetyltransferase form scaffold methoxy-6-polyprenyl- pyridoxamine 5'- dehydrogenase: (adenine(1518)-N(6)/ (guanine(527)-N(7) mannose family ABC subunit 6,7-dimethyl-8-(1- sulfanyl-L-cysteine sulfur-carrier protein] a,c-diamide GlmU: glmU 2-dehydro-3- CoA dehydrogenase: 5-aminolevulinate BR48_RS0115470 precorrin-5 protein] complex [corrinoid adenosyltranferase]-cob(II)inamide phosphate oxidase: phosphate oxidase: gap 2-dehydro-3-deoxy-6- D-xylose β-L-fucopyranose phytanoyl-CoA sugar isomerase: UvrB: uvrB 1,4-benzoquinol adenosyltransferase: α deoxy-D-gluconate phosphoglycerate holo-ACP synthase: adenine(1519)-N(6))- BR48_RS0111025 )-methyltransferase synthase: hemA [+ 3 isozymes] cobalt-precorrin-4 D-ribityl)lumazine BR48_RS0100765 BR48_RS0100765 N-acetyl- -D- 5-dehydro-4-deoxy- phosphogalactonate degradation I dioxygenase: carboxypeptidase: BR48_RS0116150 methylase UbiE: ubiE pyridoxal kinase: pgk lipoyl synthase: lipA dimethyltransferase (S)-3- 7 RsmG: rsmG [+ 2 isozymes] cysteine BR48_RS0111045 glucosamine 2-dehydro-3- D-glucuronate aldolase: D-glucosamine BR48_RS0102450 BR48_RS0120640 BR48_RS25235 an N - pyrazine-2- 6-methoxy-3- riboflavin synthase: pyridoxamine pyridoxamine kinase D-glyceraldehyde 13-DPG RsmA: rsmA hydroxybutanoyl- D-xylulose 5-aminolevulinate DNA without desulfurase: deoxygluconokinase: 3-phospho- N 6 -dimethyladenine 1518 methylguanine 527 carboxylate methyl-2-all- BR48_RS0116905 5'-phosphate 5'-phosphate PdxY: 3-phosphate gly adenosylcobalamin 1-phosphate 5-dehydro- BR48_RS0116115 D-xylose lesion BR48_RS0113290 6 1519 CoA a [cysteine desulfurase]- sufS 4-deoxy-D- D-glycerate xylose /N -dimethyladenine in 16S rRNA trans-octaprenyl- oxidase: pdxH oxidase: pdxH pdxY 1-deoxy-D-xylulose- phosphoglycerate bifunctional UDP-N- α-L-fucopyranose a holo-[EntB aryl- 2-hydroxyphytanoyl- [scaffold protein- [corrinoid adenosyltranferase]-cob(I)inamide cysteine desulfurase: 2,3-bisphosphoglycerate- isomerase: a [pyruvate dehydrogenase 3',5'-ADP succinate in 16S rRNA cobalt- precorrin-6A 1,4-benzoquinol riboflavin 5-phosphate glycine kinase: pgk acetylglucosamine glucuronate D-glyceraldehyde 5'-deoxyadenosine carrier protein] CoA a peptide with a KDGP pyruvate met E2 protein] N 6 -lipoyl-L-lysine an unsulfurated [sulfur carrier] an amino acid precorrin-5A (2Fe-2S)] complex BR48_RS0111395 oxidase diphosphorylase/ isomerase: 3-phosphate dependent xylA fucose isomerase: C-terminal glycine bifunctional cob(I)yrinic acid a,c-diamide synthase: 3-phospho- PLP ThiO: thiO glucosamine-1- kduI phosphoglycerate D-xylulose BR48_RS0115510 riboflavin kinase/ adenosyltransferase: cobO BR48_RS0103755 a thiocarboxylated- D-glycerate pyrroloquinoline phosphate N- 2-dehydro-3-deoxy- mutase: cob(I)yrinic acid a,c-diamide tetrahydrofolate biosynthesis AIR 1-deoxy-D-xylulose [ThiS sulfur- 3-deoxy-D-glycero- xylulokinase: FAD synthetase: BR48_RS0108195 L-fuculose RNase III mRNA 966 dimethyl(3- a [co-chaperone]- 3-demethylubiquinol-8 2-iminoacetate quinone biosynthesis 2,3-bisphosphoglycerate- acetyltransferase phosphogluconate a 3,5,7,9,11,13,15- an insertion sequence a guanine a monocarboxylic precorrin-6B BR48_RS0104475 adenosyltransferase: 5-phosphate carrier protein] 2,5-hexodiulosonate xylB a 5-L-glutamyl- glutathione F6P DHAP oxopropyl) cobalt- [scaffold protein- (7,8-dihydropterin- dependent GlmU: glmU aldolase: 2-phospho- an amino acid hypoglycin A processing hepta-oxo- element IS30 in 16S rRNA acid amide thr BR48_RS0111045 phosphomethylpyrimidine 2-dehydro- [peptide] sulfanium precorrin-5B bifunctional 2- 6-yl)methyl SAM phosphoglycerate BR48_RS0100350 L-idonate degradation D-xylulose substrate hexadecanoyl-[PKS-acp] 16S rRNA amidase: (2Fe-2S)] complex FMN 4-aminobenzoate synthase ThiC: thiC thiazole synthase: a PqqA peptide UDP-N-acetyl- D-glycerate aldo/keto reductase: L-threonine 3- methylglyoxal betaine-aldehyde NADP biosynthesis mutase: 3-deoxy-D- 5-phosphate transposase: (guanine(966)-N(2) cobalt-precorrin- polyprenyl-6- adenosylcobinamide diphosphate BR48_RS0113740 α-D-glucosamine phosphopyruvate fructose-6- BR48_RS0115470 synthase: gluconate 5- L-fuculose BR48_RS0110210 BR48_RS0117295 )-methyltransferase dehydrogenase: dehydrogenase: 5B (C(1))- hydroxyphenol bifunctional HMP-P BR48_RS0108195 D-glyceraldehyde L-idonate hydratase: phosphate [+ 2 isozymes] BR48_RS0108175 UDP-N-acetylglucosamine pyruvate dehydrogenase gamma- gamma- ribonuclease III: [+ 7 isozymes] BR48_RS0121130 betB methyltransferase: methylase/3- riboflavin kinase/ bifunctional dihydropteroate + 2-[(2R,5Z)-2-carboxy- 3-phosphate 1-phosphate an insertion 2 RsmD: rsmD precorrin-7 a [chaperone-ATP]- NAD 2-phospho- 1-carboxyvinyltransferase: KduD: kduD L-idonate 5- BR48_RS0122215 glutamyltransferase: ggt glutamyltransferase: ggt aldolase: fsa BR48_RS0102440 9-hydroxy-3,5,7,11,13,15- an N - a monocarboxylate methylglyoxal BR48_RS0113415 FAD synthetase: synthase: bifunctional 4-methylthiazol-5(2H)- sequence IS30 with 966 aminoacetone DMSP [co-chaperone]- demethylubiquinol 3- adenosylcobinamide NAD kinase: D-glycerate murA dehydrogenase: phosphoenol hexaoxohexadecanoyl- methylguanine hydroxymethylpyrimidine 2-dehydro-3- integrated transposon cobalt- O-methyltransferase BR48_RS0104475 kinase/adenosylcobinamide- BR48_RS0119680 BR48_RS0111335 ylidene]ethyl phosphate α BR48_RS0106615 [PKS-acp] in 16S rRNA [scaffold protein- a PqqA peptide with phosphopyruvate UDP-N-acetyl- - deoxy-D-gluconate pyruvate D-glyceraldehyde precorrin-6A UbiG: ubiG phosphate dihydropteroate kinase/ 5-dehydro- an α-(5-L- dihydroxyacetone RNase III (2Fe-2S)] complex NADP + linked Glu-Tyr residues hydratase: D-glucosamine- FAD guanylyltransferase: cobU phosphomethylpyrimidine 2-dehydro-3- D-gluconate pyruvate glutamyl)- a peptide hypoglycin B L-cysteinylglycine 3-phosphate an mRNA fragment processing cobalt-precorrin- synthase: folP enolpyruvate DHAP ubiquinol-8 kinase: thiD BR48_RS0122215 deoxygluconokinase: kinase: pyk (S)-lactaldehyde amino acid product mRNA 6A reductase: precorrin-8x 2-(2-carboxy-4- UDP-N- adenosyl-cobinamide phosphate phosphoenol BR48_RS0113290 BR48_RS24580 7,8- methylthiazol-5- precorrin-8X 5,6-dimethylbenzimidazole HMP-PP pyruvate acetylmuramate pyruvate a [chaperone- dihydropteroate yl)ethyl phosphate 2-amino-4-[5-(2-amino- α undecaprenyl-diphospho-N β-D-Glc-(1->3)-β-D-Glc-(1->6)-β- (9Z,12Z)-15,16- 6-O-cis-keto- cobalt- methylmutase: bifunctional dehydrogenase: KDGP D-gluconate UDP-N-acetyl- -D-glucosamine [EntF L-seryl- 5-guanidino-2- sn-glycerol an [2Fe-2S] ADP]-[disordered- bifunctional pyruvate γ coenzyme A D-Glc-(1->6)-β-D-Glc-(1->4)-6-O- glycerophosphoserine uroporphyrinogen-III epoxyoctadeca- N-ethylmaleimide acetoacetate mycolyl-trehalose precorrin-6B BR48_RS0110625 nicotinate-nucleotide-- 2-carboxylatoethyl)-2- murB -acetylmuramoyl-L-alanyl- - oxopentanoate 3-phosphate cluster protein adenosylcobinamide kinase: pyk carrier protein] β β form scaffold dimethylbenzimidazole folylpolyglutamate thiamine hydroxyphenyl]pentanedioate UDP-N-acetyl- gluconokinase: D-glutamyl-L-lysyl- D-alanine acetyl- -D-Glc-(1->4)- -D-Glc-(1->3) uroporphyrinogen-III C- 5-guanidino-2- 9,12-dienoate acetoacetate 6-phosphate kinase/adenosylcobinamide- α alkene reductase: L-glyceraldehyde trehalose- hydrogenobyrinate protein] complex phosphoribosyltransferase: synthase/ phosphate α-D-muramate 2-dehydro-3-deoxy- BR48_RS0101780 undecaprenyldiphospho- - -D-Gal-diphosphoundecaprenol methyltransferase: cobA oxopentanoate epoxide hydrolase: decarboxylase: phosphate pyruvate succinyl glycerophosphodiester BR48_RS0121890 3-phosphate phosphatase: cobT dihydrofolate NAD de novo biosynthesis synthase: thiE coenzyme A biosynthesis phosphogluconate uroporphyrinogen-III C- decarboxylase: BR48_RS0116530 guanylyltransferase: cobU D-gluconate muramoylpentapeptide beta-N- holo-ACP synthase: transferase OpgC: phosphodiesterase: reductase: mgrA BR48_RS0107560 otsB folate transformations III (E. coli) synthase: I (from aspartate) thiamine phosphate I (prokaryotic) aldolase: acetylglucosaminyltransferase: methyltransferase: cobA BR48_RS0117840 (9Z,12Z)-15,16- cobalt-precorrin-7 2-amino-4-[3-(2-amino-2- 6-phosphate BR48_RS0102450 β BR48_RS0110435β BR48_RS0118090 L-glyceraldehyde trehalose-cis-keto- α-ribazole 5'-phosphate BR48_RS0108455 glycolysis IV 6-O-succinoyl- -D-Glc-(1->3)- -D-Glc- precorrin-2 4-guanidinobutyraldehyde N-ethylsuccinimide acetone an [Fe-S cluster adenosylcobinamide-GDP synthase: carboxylatoethyl)-6-oxocyclohexa- BR48_RS0100350 murG dihydroxyoctadeca- 3-phosphate mono-mycolate (R)-4'- UDP-N-acetyl- (1->6)-β-D-Glc-(1->6)-β-D-Glc-(1->4) bifunctional cobalt- hydrogenobyrinate 7,8-dihydrofolate asp BR48_RS0110425 1,4-dien-1-yl]pentanedioate 9,12-dienoate biosynthesis a tetrahydrofolate phosphopantothenate α a holo-[EntF -6-O-acetyl-β-D-Glc-(1->4)-β-D-Glc- precorrin-7 (C(5))- monoglutamate bifunctional F6P -D-muramoyl- D-glyceraldehyde ditrans,octacis-undecaprenyldiphospho- UDP 3',5'-ADP sn-glycerol a,c-diamide chaperone]-ATP adenosylcobinamide- L-aspartate oxidase: pyruvate L-seryl-carrier α ser methyltransferase/ phosphopantothenoylcysteine L-alanyl-γ-D- 3-phosphate N-acetyl-(N-acetylglucosaminyl)muramoyl- (1->3)- -D-Gal-diphosphoundecaprenol 3-phosphate cobaltochelatase GDP ribazoletransferase: BR48_RS0102380 thiamine phosphate Carboxylate Degradation protein] cobalt-precorrin- methionine decarboxylase/ diphosphate--fructose- glutamyl-meso-2,6- L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine subunit CobN: cobN BR48_RS0113180 2-iminosuccinate 6-(2-amino-2-carboxylatoethyl) 6B (C(15))- synthase: metH phosphopantothenate-- 6-phosphate 1- diaminopimelate cobaltochelatase: -1,2,3,4-tetrahydroquinoline- glycolate and methyltransferase: dihydrofolate 5-methyltetrahydrofolate- cysteine ligase CoaBC: coaBC propanoyl CoA α a 7,8-dihydrofolate quinolinate (R)-4'- phosphotransferase: pyruvate decarboxylation to acetyl CoA I acetate UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N-acetylmuramoyl-L- (12Z,15Z)-9,10- adenosyl-cob(III) GDP- -D- cobS cobT reductase: 2,4-dicarboxylate glyoxylate an N-terminal L- an L-arginyl- glycerophosphoglycerol a folate BR48_RS0110635 -homocysteine adenosylcobalamin 5'-phosphate synthase phosphopantothenoyl- BR48_RS0115860 degradation I conversion alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine fumarate asp a formylmethanofuran epoxyoctadeca- NaMN hydroxypyruvate mannose cob(II)yrinate BR48_RS0114935 degradation I glutamyl-[protein] [tRNA Arg ] yrinate a,c-diamide methyltransferase: dihydrofolate NadA: nadA L-cysteine β a [pyruvate dehydrogenase pyruvate to acetyl-CoA dihydrofolate reductase: formylmethanofuran 12,15-dienoate GDP- a,c-diamide -D-fructose 1,6- undecaprenyldiphospho- cobyric acid cobalt-precorrin-8 dihydrofolate BR48_RS0113565 reductase: thiamine diphosphate glycolate propanoyl-CoA 6 5'-nucleotidase: hydroxypyruvate mannose 4,6- bifunctional bisphosphate E2 protein] N -lipoyl-L-lysine dehydrogenase: acetate BR48_RS0114935 dehydrogenase: epoxide hydrolase: synthase: reductase: glycine cleavage BR48_RS0114935 quinolinate 6-(2-amino-2-carboxylatoethyl) glycolate acyl-CoA pyruvate muramoylpentapeptide beta-N- glycerophosphodiester BR48_RS0116480 isomerase: hyi dehydratase: serine phosphopantothenoylcysteine BR48_RS0122200 acetate- arginyltransferase: L-aspartate oxidase: dihydrofolate reductase: BR48_RS0119600 BR48_RS0116530 BR48_RS0113480 BR48_RS0113900 system protein -7-hydroxy-8-oxo-1,2,3,4,7,8- oxidase: carboxylase acetylglucosaminyltransferase: phosphodiesterase: gmd a 7,8-dihydrofolate hydroxymethyltransferase: a 5-methyltetrahydrofolate dihydrofolate carboxylating decarboxylase/ fructose- pdhA -CoA BR48_RS0116850 BR48_RS0102380 BR48_RS0113900 BR48_RS0119610 (12Z,15Z)-9,10- β glcF glcE dihydrolipoyl glycolate and murG BR48_RS0118090 -D- tartronate GDP-4-dehydro- GcvH: gcvH adenosylcobalamin reductase: phosphopantothenate-- hexahydroquinoline- subunit beta: ligase: acs a 7,8-dihydrofolate a methanofuran adenosylcobyrate BR48_RS0116890 nicotinate- bisphosphate dehydrogenase: pyruvate glyoxylate dihydroxyoctadeca- ribosylnicotinate semialdehyde α-D-rhamnose phosphopantothenate biosynthesis I [+ 2 isozymes] BR48_RS0113900 cysteine ligase CoaBC: coaBC 2,4-dicarboxylate glyoxylate BR48_RS0117650 cobyrinate nucleotide aldolase class I: (S)-methylmalonyl- BR48_RS0108990 dehydrogenase degradation II acetyl-CoA an N-terminal 12,15-dienoate thymidylate thiamine diphosphate ditrans,octacis-undecaprenyldiphospho-N- diphosphorylase: BR48_RS0109965 glyoxylate CoA (acetyl- UDP Arg L-arginiyl-L- 2-iminosuccinate succinate glycerol sn-glycerol a tetrahydrofolate 4'-phosphopantetheine [+ 2 isozymes] acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- a tRNA 3-methyl-2-oxobutanoate synthase: nadC biosynthesis III glycolate 3-phosphate a (6S)-5- fructose- carboligase: methylmalonyl- transferring) γ glutamyl-[protein] BR48_RS0113905 (Staphylococcus) 6-(2-amino-2-carboxyethyl) glycolate alanyl- -D-glutamyl-L-lysyl-D-alanyl-D-alanine 3-methyl-2-oxobutanoate bifunctional formyltetrahydrofolate pantetheine- bisphosphate gcl CoA E1 component methylenetetrahydrofolate 2-methyladeninyl adenosylcobamide NaMN 2-(2-carboxy-4- oxidase: glcF glcE methylenetetrahydrofolate 5-formyltetrahydrofolate phosphate -7,8-dioxo-1,2,3,4,7,8- tartronate epimerase: mce subunit cob(II)yrinate hydroxymethyltransferase: reductase: BR48_RS0113595 biosynthesis from adenosylcobinamide-GDP HMP-PP methylthiazol-5- aldolase class II: a [pyruvate dehydrogenase pyruvate a [pyruvate dehydrogenase D-gluconate dehydrogenase/ adenylyltransferase: hexahydroquinoline alpha: pdhA glyoxylate an N-terminal L- poly-3- sn-glycero-3- (9Z,15Z)-12,13- a double a,c-diamide BR48_RS0100610 cyclo-ligase: nicotinate-nucleotide yl)ethyl phosphate BR48_RS0119840 semialdehyde (R)-methylmalonyl- 6 dehydrogenase 6 an L-arginyl- L,L- 5 methylenetetrahydrofolate 2,4-dicarboxylate E2 protein] N - E2 protein] N -S- degradation methanethiol O-acetyl-L- a supercoiled duplex DNA epoxy-octadeca- a 3-oxo-δ -steroid ferroheme o acetamide methenyltetrahydrofolate BR48_RS0110350 coaD CoA aspartyl-[protein] Arg hydroxyoctanoate phosphoethanolamine stranded DNA 3-methyl-2-oxobutanoate 2-methyladenine adenylyltransferase: 2-hydroxy-3- dihydrolipoyl-L-lysine complex acetyldihydrolipoyl-L-lysine homoserine [tRNA ] diaminopimelate reductase [NAD(P)H]: metF cyclohydrolase FolD: folD pyrroloquinoline- malate synthase G: DNA helicase: 9,15-dienoate ketosteroid DNA/RNA amidase: hydroxymethyltransferase: a 5,10- a 5,10- BR48_RS0109700 thiamine 3'-dephospho- oxopropionate methylmalonyl- dihydrolipoamide D-gluconate LL-diaminopimelate heme A synthase: nicotinate-nucleotide-- quinone synthase triose-phosphate BR48_RS0106170 BR48_RS0112060 epoxide hydrolase: isomerase: nuclease BR48_RS0115470 panB methylenetetrahydrofolate methenyltetrahydrofolate nicotinate adenine phosphate CoA reductase: CoA mutase: acetyltransferase: gluconokinase: glycerophosphodiester aminotransferase: BR48_RS0117065 dimethylbenzimidazole PqqC: pqqC isomerase: O-acetylhomoserine polyhydroxyalkanoate ATP-dependent DNA BR48_RS0116530 dinucleotide synthase: dephospho- BR48_RS0119460 BR48_RS0103270 BR48_RS0122195 BR48_RS0101780 arginyltransferase: phosphodiesterase: BR48_RS0118280 SfsA: sfsA [+ 2 isozymes] bifunctional BR48_RS0122250 (S)-malate aminocarboxypropyltransferase: depolymerase: phaZ helicase RecG: recG BR48_RS0111585 2-dehydropantoate phosphoribosyltransferase: thiE D-glyceraldehyde D-gluconate BR48_RS0116850 (9Z,15Z)-12,13- a 3-oxo- methylenetetrahydrofolate CoA kinase: pyrroloquinoline quinone DHAP methylmalonyl- BR48_RS0117205 BR48_RS0118090 (S)-2,3,4,5- a 5'-phosphooligonucleotide ferroheme a acetate cobT NAD+ synthase: NAD+ synthase: 3-phosphate D-glycerate 6-phosphate a single stranded DNA dihydroxyoctadeca- ∆ 4 -steroid dehydrogenase/ thiamine phosphate BR48_RS0108635 CoA tetrahydrodipicolinate 2-dehydropantoate BR48_RS0113000 BR48_RS0113000 an N-terminal 9,15-dienoate 2-reductase: bis(guanylyl molybdopterin) cofactor sulfurylation methenyltetrahydrofolate synthase: mutase: scpA poly-3- poly-3- 2-methyladenine coenzyme A type I acetate a tRNA Arg L-arginiyl-L- ethanolamine sn-glycerol cyclohydrolase FolD: folD NAD + BR48_RS0110425 acetyl-CoA met hydroxyoctanoate hydroxyoctanoate BR48_RS0106220 adenosylcobinamide- ribotide phosphate glyceraldehyde- succinyl-CoA aspartyl-[protein] 3-phosphate adeninyl adenosylcobamide biosynthesis β-alanine 10 GDP benzimidazolyl adenosylcobamide 3-phosphate 2-phospho- Cofactor, Prosthetic Group, (R)-pantoate cys an N -formyltetrahydrofolate thiamine from adenosylcobinamide-GDP biosynthesis from adenosylcobinamide-GDP dehydrogenase: D-glycerate Electron Carrier Degradation phosphate adenosylcobinamide- gap phosphoglycerate 3-phospho- an N 10 - 5-amino-4- DNA combined with RNase R degradation (2R,3S)-3- (2S)- 2-hydroxy-2- cysteine PRPP 2-chloroacetate 2-decaprenylphenol vernolate a double stranded DNA pantoate--beta-alanine GDP benzimidazole kinase: pgk vitamin B degradation formyltetrahydrofolate phe imidazolecarboxyamide exogenous DNA to form desulfurase: sufS adenine D-glycerate 6 substrate RNA isopropylmalate ethylmalonyl-CoA methylpropanenitrile ligase: BR48_RS0102370 a recombinational junction haloacid dehalogenase cysteine desulfurase: ribazoletransferase: Holliday junction DNA gyrase 3-isopropylmalate methylmalonyl- nitrile 13-DPG type II: BR48_RS0101090 2-polyprenylphenol epoxide hydrolase: 5-methylbenzimidazolyl adenosylcobamide BR48_RS0113180 nicotinate-nucleotide-- pyridoxamine pyridoxine resolvase RuvX: ruvX subunit A: gyrA dehydrogenase: CoA hydratase: bis(guanylyl BR48_RS0111395 nicotinate-nucleotide-- phenylalanine 4- adenine 6-hydroxylase: ubiB BR48_RS0116530 biosynthesis from adenosylcobinamide-GDP thiamine dimethylbenzimidazole ribonuclease haloacid dehalogenase leuB epimerase: mce nthB nthA (R)-pantothenate molybdopterin) cofactor an [L-cysteine desulfurase]- dimethylbenzimidazole Amine and Polyamine Degradation phosphoribosyltransferase: crossover junction [+ 3 isozymes] Coα-[α-(2- phosphoribosyltransferase: 2-phospho- monooxygenase: R: rnr type II: BR48_RS0108790 (9Z)-12,13- BR48_RS0122855 endodeoxyribonuclease 3-(all-trans-decaprenyl) a negatively 4-methyl-2- (2R)- formate S-sulfanyl-L-cysteine 5-methylbenzimidazole methyladenin-9-yl)]-Co phosphoribosyltransferase: thiamine cobT phhA dihydroxyoctadeca- 2-hydroxyisobutyramide type I pantothenate D-glycerate resolution of recombinationalRuvC: ruvC glycolate benzene-1,2-diol supercoiled DNA oxopentanoate ethylmalonyl-CoA dehydrogenase cysteine β-adenosylcobamide cobT diphosphokinase: benzimidazole glycine betaine degradation I ethanolamine utilization 9-enoate kinase: BR48_RS0108545 phosphopyruvate allantoin degradation ectoine degradation L-carnitine degradation I junction formation accessory desulfurase: sufS nicotinate-nucleotide-- BR48_RS0109915 adenosylcobinamide- ribotide 10 a nucleoside 5'- 5'-phosphate adenine ribotide hydratase: to glyoxylate III 4a-hydroxy-N - a diribonucleotide sulfurtransferase dimethylbenzimidazole GDP phosphate pyridoxal tyr AICAR of two intact strands (R)-4'-phosphopantothenate cysteine desulfurase: adenosylcobinamide- phosphate thiamine BR48_RS0122215 glycine betaine formyltetrahydrofolate monophosphate FdhD: fdhD phosphoribosyltransferase: ectoine ethanolamine L-carnitine BR48_RS0111395 GDP diphosphate betaine--homocysteine (S)-(+)-allantoin pyridoxal 4- a [bis(guanylyl molybdopterin) cobT molybdopterin biosynthesis adenosylcobinamide- phosphoenol ectoine [bis-MGD cofactor Coα-[α-(2- pyruvate S-methyltransferase: bmt allantoinase hydroxyectoine dehydrogenase: cofactor chaperone]- 5-methylbenzimidazole thiamine diphosphate GDP hydrolase carnitine--CoA chaperone]-bis-MGD adenosylcobinamide- methyladenin-7-yl)]-Co adenosylcobinamide- N,N-dimethylglycine PuuE: puuE utilization BR48_RS0115730 an L-1- an (S-diacyl-sn- a 5' triphospho- a 2-(all-trans- S-sulfanyl-L-cysteine biosynthesis I (E. coli) ribazoletransferase: pyruvate DoeA: doeA ligase: glycyl-glycine glutathione a β-D-mannoside coenzyme A 2-nonaprenylphenol 5,6-dihydrouracil MeOH a maltodextrin Fe 2+ GDP ribotide phosphate β-adenosylcobamide GDP cys allantoinase (2S)-2-acetamido- dehydratase phosphatidylethanolamine glyceryl)-L-cysteinyl- [mRNA] polyprenyl)phenol ATP BR48_RS0113180 kinase: pyk BR48_RS0121925 4-pyridoxolactone S-adenosyl-L- ribazoletransferase: GTP 2-[(2R,5Z)- PuuE: puuE 4-aminobutanoate EutB: eutB [apolipoprotein] RNA NAD-dependent catalase: malto- formate dipyrromethane 2-polyprenylphenol 2-polyprenylphenol methionine salvage II adenosylcobinamide- cysteine 2-carboxy-4- α α allantoate N-alpha-acetyl pyrophosphohydrolase: dihydropyrimidine oligosyltrehalose bacterioferritin: bfr dehydrogenase BR48_RS0113180 Co -[ - pyruvate acetaldehyde beta-mannosidase: BR48_RS0104190 cofactor biosynthesis molybdopterin- desulfurase: methylthiazol-5(2H gamma- CoA pyrophosphatase: 6-hydroxylase: ubiB 6-hydroxylase: ubiB synthase: treY accessory GDP GTP 3',8- (benzimidazolyl)]-Co NAD salvage pathway I (PNC VI cycle) diaminobutyric apolipoprotein N- BR48_RS0109480 dehydrogenase [+ 3 isozymes] Coα-[α-(adenin-9-yl)]- sufS )-ylidene]ethyl glutamyltransferase: ggt BR48_RS0101690 BR48_RS0122925 a 3-(all-trans SAH ribazoletransferase: an apo-[hydroxymethylbilane synthase cyclase HMP-PP β-adenosylcobamide acid (R)-carnitinyl-CoA acyltransferase: lnt a 5'-phospho- 3-(all-trans-nonaprenyl) subunit PreA: preA a maltooligosyl- sulfurtransferase crotonobetainyl- formaldehyde Fe 3+ BR48_RS0113180 Coβ-adenosylcobamide adenylyltransferase cysteine desulfurase: phosphate sarcosine -polyprenyl) uracil trehalose adenosylhomocysteinase: FdhD: fdhD synthase]-L-cysteine MoaA: moaA 5'-phosphate NAD + deacetylase N-acetylglucosamine 4-pyridoxate [mRNA] benzene-1,2-diol 5'-phosphate γ CoA β benzene-1,2-diol MoeB: moeB BR48_RS0111395 (8S)-3',8-cyclo-7,8- NAD(+) DoeB: doeB -butyrobetainyl- an N-acyl-(S-diacyl- -D- a non glycosylated BR48_RS0108490 α α (S)-ureidoglycine degradation II hydratase: caiD a 2-acyl-1-lyso- γ-L-glutamyl- Co -[ -(5- a carboxy-adenylated an [L-cysteine dihydroguanosine thiamine CoA:carnitine L-cysteinylglycine mannopyranose 3',5'-ADP 4'-phosphopantetheine L-homocysteine sulfo-bis(guanylyl a [hydroxymethylbilane diphosphatase: nudC L-2,4- N-acetyl-D- phosphatidylethanolamine sn-glyceryl)-L- glycylglycine sugar acceptor methylbenzimidazolyl)]- [small subunit of desulfurase]-S- 5'-triphosphate phosphate NAD+ synthase: acetyl-CoA ethanol CoA transferase: synthase] ES intermediate (S)-ureidoglycine cysteinyl-[lipoprotein] molybdopterin) cofactor β 2 Coα-[α- diaminobutanoate glucosamine Co -adenosylcobamide molybdopterin synthase] sulfanyl-L-cysteine cyclic pyranopterin synthase: BR48_RS0113000 N-acetylglucosamine BR48_RS0114315 methionine synthase: metH Coα-[α-(adenin-7-yl)]- (benzimidazolyl)]-Co NAD+ synthase: aminohydrolase: γ-butyrobetainyl- crotonobetainyl- 5-formyl-3-hydroxy-2- 5'-phosphate hydroxymethylbilane monophosphate thiE gly kinase: Coβ-adenosylcobamide β-adenosylcobamide BR48_RS0113000 BR48_RS0104120 CoA CoA allantoin degradation methylpyridine-4-carboxylate N,N',N''- 5-methyltetrahydrofolate- synthase: hemC synthase thiamine phosphate 5-formyl- 6-(hydroxymethyl) cytidine BR48_RS0114395 a methanofuran + trans-aconitate D-glucopyranose L-idonate -homocysteine N-acetyl-D- to glyoxylate I tetrahydrosarcinapterin H hydrogencarbonate triacetylchitotriose 2-heptaprenylphenol 2-hydroxyisobutyramide ethanol a [hydroxymethylbilane MoaC: moaC synthase: nicotinate adenine dinucleotide NMN serine (S)-ureidoglycolate -7,8-dihydropterin nucleoside methyltransferase: folate polyglutamylation a thiocarboxylated acetyl phosphate glucosamine glucose 1- L-idonate 5- Coα-[α-(5- synthase] ES intermediate BR48_RS0110425 hydroxymethyltransferase: L-aspartate 4- 2-amino-4-hydroxy-6- amidase: trans-aconitate 2- catalase: deaminase: BR48_RS0113565 3 [small subunit of cyclic pyranopterin 6-phosphate (S)-(+)-allantoin 2-polyprenylphenol dehydrogenase: dehydrogenase: methylbenzimidazolyl)]- nicotinate-nucleotide BR48_RS0116890 ureidoglycolate semialdehyde formylmethanofuran-- hydroxymethyldihydropteridine beta-N- BR48_RS0115470 methyltransferase: BR48_RS0104190 BR48_RS0112265 hydroxymethylbilane molybdenum cofactor biosynthesis molybdopterin synthase] phosphate bis(guanylyl molybdenum N-acetylglucosamine- crotonobetainyl- allantoinase 3-hydroxy-2-methylpyridine- carbonic anhydrase: 6-hydroxylase: ubiB BR48_RS0107500 BR48_RS0106615 a tetrahydrofolate Coβ-adenosylcobamide adenylyltransferase: lyase: tetrahydromethanopterin diphosphokinase: folK acetylhexosaminidase: [+ 2 isozymes] BR48_RS0119535 [+ 3 isozymes] met synthase: hemC thiamine 6-phosphate CoA reductase: PuuE: puuE 4,5-dicarboxylate BR48_RS0109330 (E)-3- [+ 3 isozymes] cofactor) biosynthesis BR48_RS0109700 ser BR48_RS0119520 (7,8-dihydropterin- nagZ 3-(all-trans-heptaprenyl) 2-hydroxy-2- D-glucono- 5-dehydro- phosphate deacetylase: nagA N-formyltransferase: fhcD acetaldehyde uridine a [hydroxymethylbilane molybdopterin MoO - BR48_RS0117920 allantoinase 6-yl)methyl (methoxycarbonyl) 1,5-lactone D-gluconate methionine molybdate 2 ureidoglycolate benzene-1,2-diol methylpropanoate bifunctional serine formate-- synthase] ES intermediate synthase: molybdopterin threonine/serine acetate D-glucosamine PuuE: puuE diphosphate pent-2-enedioate adenosyltransferase: 4 molybdopterin NaMN nicotinamide lyase: N,N'- N-acetyl-D- folylpolyglutamate hydroxymethyltransferase: tetrahydrofolate molybdenum hydroxymethylpyrimidine BR48_RS0102020 cofactor dehydratase: asp 6-phosphate allantoate CO H O BR48_RS0106110 5,6-dimethylbenzimidazole hydroxymethylbilane molybdopterin BR48_RS0103525 3-hydroxy-2-methylpyridine- tetrahydrosarcinapterin a formylmethanofuran 2 2 diacetylchitobiose glucosamine synthase/ BR48_RS0116890 ligase: ABC salvage BR48_RS0120320 biosynthesis I (aerobic) synthase: hemC bifunctional 5-carboxylate dihydrofolate BR48_RS0123010 transporter thiamine molybdenum cofactor glyoxylate choline-O-sulfate SAM 4-amino-2-methyl-5- molybdopterin nicotinamidase/ [+ 2 isozymes] synthase: a 5,10- a holo-[hydroxymethylbilane ATP-binding diphosphate guanylyltransferase nicotinate degradation α 34 1915 55 5,6- 10 riboflavin pyrimidinemethanol phosphoribosyltransferase: pyrazinamidase: pncA 2-aminoprop-2-enoate L-carnitine degradation II -D-glucosamine 2-amino-6-[1-hydroxyethyl]- a 5-carboxymethylaminomethyluridine a pseudouridine α-D-mannose a uridine CTP BR48_RS0108455 methylenetetrahydrofolate an N - synthase] protein: modC bifunctional glutathione MobA: mobA a formylmethanofuran THMPT D-glucopyranose L-idonate bifunctional riboflavin molybdopterin Leu 4-guanidinobutyramide dihydrothymine pncB 6-phosphate choline sulfate (S)-ureidoglycolate 7-methyl-7,8-dihydropterin in tRNA in 23S rRNA 1-phosphate in tRNA 2'-deoxycytidine bifunctional formyltetrahydrofolate hydroxymethylpyrimidine biosynthesis E-2-(acetamidomethylidene) NAD-dependent kinase/FAD synthetase: adenine nicotinate 2-amino-4-hydroxy-6- tRNA (cytidine(34) 23S rRNA amidase: tRNA glucose 1- L-idonate 5- molybdate kinase/ bis(molybdenum urea degradation II L-carnitine glucosamine- choline- succinate 5'-triphosphate a tetrahydrofolate folylpolyglutamate bifunctional BR48_RS0104475 dinucleotide ureidoglycolate -2'-O)- (pseudouridine(1915)- phosphomannomutase: dehydrogenase: dihydropyrimidine dehydrogenase: phosphomethylpyrimidine cytidylyl molybdenum cofactor) putrescine degradation I carnitine 3- 6-phosphate sulfatase: betC formylmethanofuran-- hydroxymethyldihydropteridine BR48_RS0115470 pseudouridine(55) deaminase: synthase/ folylpolyglutamate FMN cys glu lyase: methyltransferase: N(3))-methyltransferase BR48_RS0106360 dehydrogenase BR48_RS0106615 thioredoxin lipoate biosynthesis dehydrogenase: deaminase: diphosphokinase: folK [+ 2 isozymes] synthase TruB: truB BR48_RS0107500 BR48_RS0105240 dihydrofolate synthase/ tetrahydrofolate salvage from molybdopterin kinase: thiD cofactor sulfurylation molybdenum cofactor choline BR48_RS0119520 tetrahydromethanopterin subunit PreA: preA pathway and incorporation I 2-iminopropanoate urea [1-(2-amino-7-methyl-4-oxo- BR48_RS0122890 3 RlmH: rlmH 55 5,10-methenyltetrahydrofolate BR48_RS0117925 BR48_RS0121145 N-formyltransferase: fhcD an N - D-mannopyranose a pseudouridine D-glucono- 5-dehydro- synthase: dihydrofolate molybdotransferase HMP-P guanylyltransferase glutathione- putrescine a 5-carboxymethylaminomethyl- 4-guanidinobutanoate thymine UTP cytidylyl molybdenum urease: choline ureidoglycolate 7,8-dihydro-3H-pteridin- 1915 6-phosphate in tRNA 1,5-lactone D-gluconate BR48_RS0108455 MobA: mobA glutaredoxin 3-dehydrocarnitine 2'-O-methyluridine 34 in tRNA Leu methylpseudouridine synthase: a 5,10- MoeA: an oxidized glutamate-- cofactor (trioxo) BR48_RS0104885 F6P dehydrogenase: lyase: succinate semialdehyde 6-yl)]ethyl diphosphate bifunctional bis(guanylyl redox reactions an octanoyl-[acp] in 23S rRNA 4-aminobenzoate a 5,10- BR48_RS0108455 BR48_RS0122275 thioredoxin cysteine ligase: BR48_RS0104890 BR48_RS0103525 5-formyl- methenyltetrahydrofolatebifunctional hydroxymethylpyrimidine lipoyl(octanoyl) betA a methanofuran biosynthesis 10 FMNH BR48_RS0104640 molybdopterin) methylenetetrahydrofolate an N - 2 an [MCD cofactor glutathione 4-aminobutanal ureC tetrahydromethanopterin methylenetetrahydrofolate MoO - kinase/ cofactor transferase pyruvate glyoxylate 2 ammonium betaine aldehyde formyltetrahydrofolate dehydrogenase/ phosphomethylpyrimidine chaperone]-MCD LipB: lipB chorismate 5,6-dimethylbenzimidazole molybdopterin thioredoxin- γ-L-glutamyl- a [lipoyl-carrier protein] gamma- methenyltetrahydrofolate kinase: thiD cysteine trimethylaminoacetone betaine-aldehyde 2,5-diamino-6-(5- aminodeoxychorismate/ synthase: bluB cofactor 6 aminobutyraldehyde 5,10-methenyl- 4a-hydroxy-N 10 - N,N'- dCTP disulfide L-cysteine a reduced N -octanoyl-L-lysine 3-phenyl-2- uroporphyrinogen-I 2-phosphoglycolate L-fuconate L-iditol cellulose anthranilate synthase: cyclohydrolase FolD: folD desulfurase: sufS dehydrogenase: phospho-D-ribitylamino) diacetylchitobiose an N 10 - reductase: glutathione dehydrogenase: tetrahydrosarcinapterin formyltetrahydrofolate oxopropanoate 2'-deoxycytidine bis(guanylyl tungstenpterin) 5,6-dimethylbenzimidazole HMP-PP glutaredoxin lipoyl betB pyrimidin-4(3H)-one pabB BR48_RS0117990 trxB synthase: cysteine desulfurase: menaquinol-6 biosynthesis BR48_RS0118425 bifunctional 4a-hydroxytetrahydrobiopterin beta-N- uroporphyrinogen phosphoglycolate L-fuconate L-iditol 2- 4-amino-4- cofactor biosynthesis menaquinol-8 biosynthesis formyltetrahydrofolate synthase: lipA methenyltetrahydromethanopterin 4-hydroxyphenylpyruvate endoglucanase: 5'-triphosphate gshB BR48_RS0111395 glutaredoxin diaminohydroxyphosphoribosylaminopyrimidine dehydratase: acetylhexosaminidase: decarboxylase: phosphatase: dehydratase: dehydrogenase: deoxychorismate phosphoribosylglycinamide a [lipoyl-carrier 4-aminobutanoate glycine betaine cyclohydrolase: BR48_RS0119645 dioxygenase: hppD BR48_RS0119035 deaminase: menaquinol-9 biosynthesis a [cytidylyl molybdenum 3: grxC glycine betaine BR48_RS0119620 nagZ BR48_RS0108660 BR48_RS0113055 BR48_RS0100595 BR48_RS0107115 formyltransferase: demethylmenaquinol-6 protein]-N 6 -[(R)- deaminase/5-amino-6-(5-phosphoribosylamino) BR48_RS0105240 GTP demethylmenaquinol-8 glutathione cofactor chaperone]- 10 N-acetyl-D- 2-dehydro-3- bis(tungstenpterin) BR48_RS0101955 a reduced bifunctional a protein with dihydrolipoyl]-L-lysine uracil reductase RibD: ribD 5-formyl- an N -formyl- (2-hydroxyphenyl) keto-L-sorbose a cellodextrin dUTP cytidylyl molybdenum 5-amino-6-(5-phospho- glucosamine coproporphyrinogen I glycolate deoxy-L-fuconate cofactor bifunctional demethylmenaquinol-9 thiamine diphosphate thioredoxin reduced L- tetrahydrosarcinapterin 7,8-dihydrofolate acetate molybdenum cofactor (sulfo-dioxo) demethylmenaquinone D-ribitylamino)uracil demethylmenaquinone a tetrahydrofolate bifunctional salvage III methyltransferase/2- cysteine residues 4-aminobenzoate cofactor sulfulylation acyl carrier molybdenum cofactor methyltransferase/2- demethylmenaquinone methoxy-6-polyprenyl- (eukaryotes) thiamine protein activation guanylyltransferase methoxy-6-polyprenyl- MoO - methyltransferase/2- 1,4-benzoquinol 3 thiamine MobA: mobA 1,4-benzoquinol molybdopterin methoxy-6-polyprenyl- diphosphokinase: methylase UbiE: ubiE an apo acyl- methylase UbiE: ubiE cofactor molybdenum 1,4-benzoquinol menaquinol-6 carrier protein menaquinol-8 BR48_RS0109915 bis(guanylyl cofactor sulfurase: methylase UbiE: ubiE thiamine holo-ACP synthase: tungstenpterin) cofactor Mo(O) (S)-BR48_RS0114285 2 menaquinol-9 diphosphate BR48_RS0102450 molybdopterin a holo acyl- cofactor carrier protein a reduced a reduced a reduced plastocyanin plastocyanin plastocyanin an oxidized phosphonate an oxidized an oxidized plastocyanin an (aminoalkyl)phosphonate molybdate thiamine plastocyanin plastocyanin ammonium an alkylphosphonate

cytochrome ModC ThiQ RS0119890 CtaD PhnC Amt c oxidase

phosphonate molybdate thiamine ammonium O O an (aminoalkyl)phosphonate 2 2 O an alkylphosphonate H O H O 2 2 2 H O 2 This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.