Implementing Agreement Between the National Aeronautics and Space
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Mir-125 in Normal and Malignant Hematopoiesis
Leukemia (2012) 26, 2011–2018 & 2012 Macmillan Publishers Limited All rights reserved 0887-6924/12 www.nature.com/leu SPOTLIGHT REVIEW MiR-125 in normal and malignant hematopoiesis L Shaham1,2, V Binder3,4,NGefen1,5, A Borkhardt3 and S Izraeli1,5 MiR-125 is a highly conserved microRNA throughout many different species from nematode to humans. In humans, there are three homologs (hsa-miR-125b-1, hsa-miR-125b-2 and hsa-miR-125a). Here we review a recent research on the role of miR-125 in normal and malignant hematopoietic cells. Its high expression in hematopoietic stem cells (HSCs) enhances self-renewal and survival. Its expression in specific subtypes of myeloid and lymphoid leukemias provides resistance to apoptosis and blocks further differentiation. A direct oncogenic role in the hematopoietic system has recently been demonstrated by several mouse models. Targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopoietic differentiation. Leukemia (2012) 26, 2011–2018; doi:10.1038/leu.2012.90 Keywords: microRNA; hematopoiesis; hematological malignancies; acute myeloid leukemia; acute lymphoblastic leukemia MicroRNAs (miRNAs) are 21–23-nucleotide non-coding RNAs that nucleotides with the seed region of miR-125b (ebv-miR-BART21-5p, have crucial roles in fundamental biological processes by ebv-miR-BART8 and rlcv-miR-rL1-25). In humans, as in most of the regulating the levels of multiple proteins. They are transcribed genomes, there are two paralogs (hsa-miR-125b-1 on chromosome as primary miRNAs and processed in the nucleus by the RNase III 11 and hsa-miR-125b-2 on chromosome 21), coding for the same endonuclease DROSHA to liberate 70-nucleotide stem loops, the mature sequence. -
The Space Race
The Space Race Aims: To arrange the key events of the “Space Race” in chronological order. To decide which country won the Space Race. Space – the Final Frontier “Space” is everything Atmosphere that exists outside of our planet’s atmosphere. The atmosphere is the layer of Earth gas which surrounds our planet. Without it, none of us would be able to breathe! Space The sun is a star which is orbited (circled) by a system of planets. Earth is the third planet from the sun. There are nine planets in our solar system. How many of the other eight can you name? Neptune Saturn Mars Venus SUN Pluto Uranus Jupiter EARTH Mercury What has this got to do with the COLD WAR? Another element of the Cold War was the race to control the final frontier – outer space! Why do you think this would be so important? The Space Race was considered important because it showed the world which country had the best science, technology, and economic system. It would prove which country was the greatest of the superpowers, the USSR or the USA, and which political system was the best – communism or capitalism. https://www.youtube.com/watch?v=xvaEvCNZymo The Space Race – key events Discuss the following slides in your groups. For each slide, try to agree on: • which of the three options is correct • whether this was an achievement of the Soviet Union (USSR) or the Americans (USA). When did humans first send a satellite into orbit around the Earth? 1940s, 1950s or 1960s? Sputnik 1 was launched in October 1957. -
India and China Space Programs: from Genesis of Space Technologies to Major Space Programs and What That Means for the Internati
University of Central Florida STARS Electronic Theses and Dissertations, 2004-2019 2009 India And China Space Programs: From Genesis Of Space Technologies To Major Space Programs And What That Means For The Internati Gaurav Bhola University of Central Florida Part of the Political Science Commons Find similar works at: https://stars.library.ucf.edu/etd University of Central Florida Libraries http://library.ucf.edu This Masters Thesis (Open Access) is brought to you for free and open access by STARS. It has been accepted for inclusion in Electronic Theses and Dissertations, 2004-2019 by an authorized administrator of STARS. For more information, please contact [email protected]. STARS Citation Bhola, Gaurav, "India And China Space Programs: From Genesis Of Space Technologies To Major Space Programs And What That Means For The Internati" (2009). Electronic Theses and Dissertations, 2004-2019. 4109. https://stars.library.ucf.edu/etd/4109 INDIA AND CHINA SPACE PROGRAMS: FROM GENESIS OF SPACE TECHNOLOGIES TO MAJOR SPACE PROGRAMS AND WHAT THAT MEANS FOR THE INTERNATIONAL COMMUNITY by GAURAV BHOLA B.S. University of Central Florida, 1998 A dissertation submitted in partial fulfillment of the requirements for the degree of Master of Arts in the Department of Political Science in the College of Arts and Humanities at the University of Central Florida Orlando, Florida Summer Term 2009 Major Professor: Roger Handberg © 2009 Gaurav Bhola ii ABSTRACT The Indian and Chinese space programs have evolved into technologically advanced vehicles of national prestige and international competition for developed nations. The programs continue to evolve with impetus that India and China will have the same space capabilities as the United States with in the coming years. -
Outer Space Pretend Play Let Your Imagination Blast Off Into Outer Space! Astronauts and Scientists Study the Earth from Outer Space
UAMN Virtual Early Explorers: Amazing Earth Outer Space Pretend Play Let your imagination blast off into outer space! Astronauts and scientists study the Earth from outer space. They take pictures of Earth's surface and measure cloud cover, sea levels, glacier movements, and more. Instructions: Step 1: Work together with your child(ren) to create an area for your space station. Use cardboard boxes or pieces, aluminum foil, recycled plastic bottles, yarn, ribbons, bottlecaps, fabric scraps, or any other materials you have available. It can be as small or as large as you want it to be. Step 2: Pretend to be an astronaut on your space station. Let your child lead with ideas for imaginative play! Left: www.youclevermonkey.com/2016/01/space-pretend-play.html Center and right: pocketofpreschool.com/space-station-dramatic-play/ Suggestions and Prompts: • What is daily life like on your space station? Where and how do the astronauts eat, sleep, and exercise? • What sort of research are you doing on your space station? See the Studying Earth From Above sheet for ideas. • How will you control your space station’s orbit around Earth? Create a control panel so you can “pilot” the station! • How will you get more supplies? Build a rocket to launch a space shuttle to the station! • Use a phone or digital camera to take pictures from your space station. Astronauts on the International Space Station take pictures of the Earth’s surface every day! UAMN Virtual Early Explorers: Amazing Earth Studying Earth From Above NASA is best known for exploring outer space, but it also conducts many missions to investigate Earth from above. -
The New American Space Age: a Progress Report on Human Spaceflight the New American Space Age: a Progress Report on Human Spaceflight the International Space
The New American Space Age: A PROGRESS REPORT ON HUMAN SpaCEFLIGHT The New American Space Age: A Progress Report on Human Spaceflight The International Space Station: the largest international scientific and engineering achievement in human history. The New American Space Age: A Progress Report on Human Spaceflight Lately, it seems the public cannot get enough of space! The recent hit movie “Gravity” not only won 7 Academy Awards – it was a runaway box office success, no doubt inspiring young future scientists, engineers and mathematicians just as “2001: A Space Odyssey” did more than 40 years ago. “Cosmos,” a PBS series on the origins of the universe from the 1980s, has been updated to include the latest discoveries – and funded by a major television network in primetime. And let’s not forget the terrific online videos of science experiments from former International Space Station Commander Chris Hadfield that were viewed by millions of people online. Clearly, the American public is eager to carry the torch of space exploration again. Thankfully, NASA and the space industry are building a host of new vehicles that will do just that. American industry is hard at work developing new commercial transportation services to suborbital altitudes and even low Earth orbit. NASA and the space industry are also building vehicles to take astronauts beyond low Earth orbit for the first time since the Apollo program. Meanwhile, in the U.S. National Lab on the space station, unprecedented research in zero-g is paving the way for Earth breakthroughs in genetics, gerontology, new vaccines and much more. -
Molds Aboard the International Space Station
Mold Species in Dust from the International Space Station Identified and Quantified by Mold Specific Quantitative PCR Stephen J. Vesper a*, Wing Wongb C. Mike Kuoc, Duane L. Piersond a National Exposure Research Laboratory (NERL), United States (US) Environmental Protection Agency, Cincinnati, OH; b Enterprise Advisory Services Inc., Houston, TX c WYLE Laboratories Inc., Houston, TX d Johnson Space Center, National Aeronautics and Space Administration, Houston, TX *Corresponding Author: Stephen Vesper, US EPA, 26 West M.L. King Ave., M.L. 314, Cincinnati, Ohio 45268. Phone: 513-569-7367; email: [email protected] Abstract Dust was collected over a period of several weeks in 2007 from HEPA filters in the U.S. Laboratory Module of the International Space Station (ISS). The dust was returned on the Space Shuttle Atlantis, mixed, sieved, and the DNA was extracted. Using a DNA- based method called mold specific quantitative PCR (MSQPCR), 39 molds were measured in the dust. Potential opportunistic pathogens Aspergillus flavus and A. niger and potential moderate toxin producers Penicillium chrysogenum and P. brevicompactum were noteworthy. No cells of the potential opportunistic pathogens A. fumigatus, A. terreus, Fusarium solani or Candida albicans were detected. Keywords: International Space Station, mold specific quantitative PCR, Aspergillus 1 1. Introduction Since human space exploration began, microbes have traveled with us and are ubiquitous throughout the spacecraft. Previous studies have demonstrated that bacteria, including potential pathogens, were commonly isolated in the air, water, and on surfaces aboard the Mir Space Station [12] and the International Space Station (ISS) [1,6]. Biofilms were found in the water distribution lines on the Space Shuttle Discovery [5]. -
International Space Station Basics Components of The
National Aeronautics and Space Administration International Space Station Basics The International Space Station (ISS) is the largest orbiting can see 16 sunrises and 16 sunsets each day! During the laboratory ever built. It is an international, technological, daylight periods, temperatures reach 200 ºC, while and political achievement. The five international partners temperatures during the night periods drop to -200 ºC. include the space agencies of the United States, Canada, The view of Earth from the ISS reveals part of the planet, Russia, Europe, and Japan. not the whole planet. In fact, astronauts can see much of the North American continent when they pass over the The first parts of the ISS were sent and assembled in orbit United States. To see pictures of Earth from the ISS, visit in 1998. Since the year 2000, the ISS has had crews living http://eol.jsc.nasa.gov/sseop/clickmap/. continuously on board. Building the ISS is like living in a house while constructing it at the same time. Building and sustaining the ISS requires 80 launches on several kinds of rockets over a 12-year period. The assembly of the ISS Components of the ISS will continue through 2010, when the Space Shuttle is retired from service. The components of the ISS include shapes like canisters, spheres, triangles, beams, and wide, flat panels. The When fully complete, the ISS will weigh about 420,000 modules are shaped like canisters and spheres. These are kilograms (925,000 pounds). This is equivalent to more areas where the astronauts live and work. On Earth, car- than 330 automobiles. -
Astronaut Deployable Satellite
ASTRONAUT DEPLOYABLE SATELLITE BY WILLIAM G. CLAPP \JEBER STATE UNIVERSITY SCHOOL OF TECHNOLOGY ELECTRONIC ENGINEERING TECHNOLOGY OGDEN, UTAH 84408-1703 801-626-7097 FOR AIM/UTAH STATE UNIVERSITY CONFERENCE ON SMALL SATELLITES AUGUST 3, 1990 ASTRONAUT DEPLOYABLE SATELLITE William G. Clapp The Astronaut Deployable Satellite (ADSAT) is an educational satellite being designed and built by faculty, local engineers, and students at Weber State University. The ADSAT is our third satellite project after the success of two others, NUSAT I (Challenger April 85) and WEBERSAT-OSCAR 18 (Ariane-Jan 90. The ADSAT is designed to be tossed into space by an astronaut. The 16" X 16" X 4" AnSAT is self-contained and is designed to ride into space in a mid-deck stowage locker on the shuttle. When launch is desired, the astronaut removes the AnSAT from the locker and carries it outside. The astronaut then deploys the antennas and throws the ADSAT into space. The ADSAT is designed to send to Earth voice messages concerning onboard experiments. The voice messages will be generated by an onboard speech synthesizer that verbally relays the data to low-cost scanners on the ground. ADSAT is being designed to be thrown in a couple of years if NASA will agree to the concept. INTRODUCTION Realistic engineering training at the university level is a difficult task to accomplish successfully. There is no substitute for on-the-job training that takes place after graduation. Many universities offer senior projects courses in undergraduate programs to help the student transition into their entry-level engineering positions. The School of Technology at Weber State University has implemented a rigorous one-year senior projects program that consumes about 300 hours for each student. -
Astronaut Eric
CAP’s astronaut pilots shuttle Discovery on its last Photos courtesy of NASA flight into space By Maj. Steven Solomon Civil Air Patrol member and U.S. Air C Force Col. Eric Boe took NASA’s Space Shuttle Discovery into history, piloting it on its 39th and final mission. After numerous delays attributable to technical problems and bad weather, Discovery was launched Feb. 24 to deliver the Eric Boe is strapped into his seat on Space Shuttle Permanent Multipurpose Module, Discovery to practice escaping the shuttle, in preparation packed with supplies and critical for an unlikely emergency at the pad on launch day. spare parts, and Robonaut 2, the dexterous humanoid astronaut helper, to the International Space Station. “I look at the space shuttle and there’s nothing as cool in science fiction. I really Space Shuttle appreciate that we can take something like this and put Discovery carried it in orbit,” Boe said. Robonaut 2 to the Another NASA space shuttle, the Endeavour, which International Space Boe piloted in 2008 on his first flight into space, is Station. It is the first scheduled to fly in April, and the Atlantis is scheduled humanoid robot in for late June. But, after that, NASA’s human space space. program is “up in the air.” The program escaped a death blow with a congressional compromise, but budget cuts may still derail it. “I’d love to fly in space again,” Boe said. “I’d love to get the opportunity to fly one of the new vehicles, but I consider myself very fortunate, especially now that this looks like Discovery’s last flight.” For the love of flight Boe has never met a flying machine he didn’t like. -
China's Space Program: an Overview
Order Code RS21641 Updated October 18, 2005 CRS Report for Congress Received through the CRS Web China’s Space Program: An Overview Marcia S. Smith Specialist in Aerospace and Telecommunications Policy Resources, Science, and Industry Division Summary The People’s Republic of China successfully completed its second human spaceflight mission on October 17, 2005. China is only the third country, after Russia and the United States, able to launch people into space. Its first human spaceflight was in 2003 when a single astronaut, or “taikonaut,” made a flight lasting slightly less than a day. The 2005 flight lasted five days, and involved two taikonauts. As the United States embarks upon President Bush’s “Vision for Space Exploration” to return astronauts to the Moon by 2020 and someday send them to Mars, some may view China’s entrance into the human exploration of space as a competitive threat, while others may view China as a potential partner. This report will be updated as warranted. Introduction China has been launching satellites since 1970. Most of the launches are of Chinese communications, weather, remote sensing, navigation, or scientific satellites. Some of those satellites may be for military applications, or are dual use. Some were commercial launches for foreign countries or companies, primarily placing communications satellites into orbit. China launched its first astronaut, or “taikonaut,”1 in October 2003. China has three space launch sites: Jiuquan (also called Shuang Cheng-tzu) in the Gobi desert; Xichang, in southeastern China (near Chengdu); and Taiyuan, south of Beijing. Jiuquan was China’s first launch site, and is used for launches of a variety of spacecraft, including those related to the human spaceflight program. -
Apollo-Soyuz Test Project
--.I m ...ir,,.= The document_-contains materials on the Soyuz-Apollo test and consists of two parts, prepared by the USSR and USA sides res- pectively. Both parts outline the purposes and program of the mission, the spacecraft design, the flight plan and information on Joint and unilateral scientific experiments. Brief biographies of the cosmonauts and astronauts, the Joint mission crew members_ are also presented. The document covers technical support activities providing mission control and gives information about the ASTP Soviet and American leaders. As the USSR and USA parts of the document have been prepared independently, there might be duplication in the sections dealing with the Joint activities. The document is intended for press representatives and various mass information means. CONTENTS Page I.0 INTRODUCTION ....................................... 10 1.1 Background ......................................... I0 1,2 Apollo-Soyuz joint test project objectives .......... 13 2.0 COMPATIBILITY PROBLEMS ................... ......... • 15 2.1 Spacecraft compatibility conditions and principal solutions accepted for Apollo-Ssyuz Test Mission .... 15 2.2 Compatibility of ground flight control personnel ... 18 2_3 Methodological compatibility ....................... 20 3.0 SOYUZ SPACECRAFT ................................... 22 3.1 PurPose. Brief data on Soyuz spacecraft flights .... 22 3.2 Soyuz spacecraft description ....................... 25 3.2.1 General description of the Soyuz spacecraft.. 25 Main characteristics ........................ -
Part 2 Almaz, Salyut, And
Part 2 Almaz/Salyut/Mir largely concerned with assembly in 12, 1964, Chelomei called upon his Part 2 Earth orbit of a vehicle for circumlu- staff to develop a military station for Almaz, Salyut, nar flight, but also described a small two to three cosmonauts, with a station made up of independently design life of 1 to 2 years. They and Mir launched modules. Three cosmo- designed an integrated system: a nauts were to reach the station single-launch space station dubbed aboard a manned transport spacecraft Almaz (“diamond”) and a Transport called Siber (or Sever) (“north”), Logistics Spacecraft (Russian 2.1 Overview shown in figure 2-2. They would acronym TKS) for reaching it (see live in a habitation module and section 3.3). Chelomei’s three-stage Figure 2-1 is a space station family observe Earth from a “science- Proton booster would launch them tree depicting the evolutionary package” module. Korolev’s Vostok both. Almaz was to be equipped relationships described in this rocket (a converted ICBM) was with a crew capsule, radar remote- section. tapped to launch both Siber and the sensing apparatus for imaging the station modules. In 1965, Korolev Earth’s surface, cameras, two reentry 2.1.1 Early Concepts (1903, proposed a 90-ton space station to be capsules for returning data to Earth, 1962) launched by the N-1 rocket. It was and an antiaircraft cannon to defend to have had a docking module with against American attack.5 An ports for four Soyuz spacecraft.2, 3 interdepartmental commission The space station concept is very old approved the system in 1967.