DOCSLIB.ORG

Minimizing Inequality in Access to Precision Medicine in Breast Cancer by Real-Time Population-Based Molecular Analysis in the SCAN-B Initiative

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Minimizing Inequality in Access to Precision Medicine in Breast Cancer by Real-Time Population-Based Molecular Analysis in the SCAN-B Initiative Original article Minimizing inequality in access to precision medicine in breast cancer by real-time population-based molecular analysis in the SCAN-B initiative L. Rydén1,4 , N. Loman2,5, C. Larsson3, C. Hegardt2, J. Vallon-Christersson2, M. Malmberg2,5, H. Lindman7, A. Ehinger2,6, L. H. Saal2 and Å. Borg2 1Department of Clinical Sciences Lund, Surgery, 2Department of Clinical Sciences Lund, Oncology and Pathology, and 3Department of Laboratory Medicine Lund, Translational Cancer Research, Lund University, and 4Department of Surgery, 5Department of Haematology, Oncology and Radiotherapy, and 6Department of Pathology and Cytology, Medicinsk Service, Skåne University Hospital, Lund, and 7Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden Correspondence to: Professor L. Rydén, Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Surgery, Medicon Village, SE-223 81, Lund, Sweden (e-mail: [email protected]) Background: Selection of systemic therapy for primary breast cancer is currently based on clinical biomarkers along with stage. Novel genomic tests are continuously being introduced as more precise tools for guidance of therapy, although they are often developed for specific patient subgroups. The Sweden Cancerome Analysis Network – Breast (SCAN-B) initiative aims to include all patients with breast cancer for tumour genomic analysis, and to deliver molecular subtype and mutational data back to the treating physician. Methods: An infrastructure for collection of blood and fresh tumour tissue from all patients newly diagnosed with breast cancer was set up in 2010, initially including seven hospitals within the southern Sweden regional catchment area, which has 1.8 million inhabitants. Inclusion of patients was implemented into routine clinical care, with collection of tumour tissue at local pathology departments for transport to the central laboratory, where routines for rapid sample processing, RNA sequencing and biomarker reporting were developed. Results: More than 10 000 patients from nine hospitals have currently consented to inclusion in SCAN-B with high (90 per cent) inclusion rates from both university and secondary hospitals. Tumour samples and successful RNA sequencing are being obtained from more than 70 per cent of patients, showing excellent representation compared with the national quality registry as a truly population-based cohort. Molecular biomarker reports can be delivered to multidisciplinary conferences within 1 week. Conclusion: Population-based collection of fresh tumour tissue is feasible given a decisive joint effort between academia and collaborative healthcare groups, and with governmental support. An infrastructure for genomic analysis and prompt data output paves the way for novel systemic therapy for patients from all hospitals, irrespective of size and location. Paper accepted 30 September 2017 Published online in Wiley Online Library (www.bjs.co.uk). DOI: 10.1002/bjs.10741 Introduction therapy to patients with hormone-sensitive tumours has improved the prognosis for those with endocrine respon- Breast cancer heterogeneity is a well recognized concept, sive breast cancer2. Moreover, systemic polychemotherapy with implications for clinical decision-making related to systemic adjuvant and palliative therapy. Its description in the adjuvant setting has led to an increased cure rate has evolved from a simplistic distinction of tumour steroid and prolonged survival for the majority of patients with hormone receptor levels (hormone sensitive versus insen- breast cancer who have node-positive and/or high-grade sitive) into a refined molecular classification based on disease, despite the lack of a specific predictive biomarker3. gene expression (GEX) patterns, as described by Perou Amplification of human epidermal growth factor receptor 2 and colleagues in 20001. The introduction of endocrine (HER2) was recognized decades ago as an important factor © 2018 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd. BJS 2018; 105: e158–e168 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Real-time population-based molecular analysis in breast cancer e159 associated with dismal outcome4. With the subsequent cancer, but also for optimal surgical and potentially med- , introduction of adjuvant HER2-targeted therapy in the ical management of incident breast cancer18 19. Finally, mid-2000s, the prognosis for patients with HER2-positive circulating tumour markers such as circulating tumour disease has become as favourable as that of patients with- cells and cell-free circulating tumour DNA are about to out this genetic aberration, and the development of differ- enter the clinical arena in breast cancer management20–23. ent HER2-directed therapies has much improved outcome This article describes the initiation and implementation even in metastatic HER2-postive disease5–10. of SCAN-B, a large and expanding population-based effort In the clinical setting today, all newly diagnosed breast prospectively including all new patients with breast can- tumours are routinely characterized by immunohistochem- cer from southern Sweden and beyond, with the aim of istry for the treatment predictive biomarkers oestrogen exploring and implementing new prognostic and predictive receptor (ER), progesterone receptor (PR) and HER2, biomarkers in routine clinical care of breast cancer. along with cell proliferation marker Ki-67 and Nottingham histological grade (NHG), and presented to a multidisci- Methods plinary conference that gives recommendations on post- operative locoregional and systemic therapy for individual Early partnership between departments of surgery patients. All these markers can be combined into the St and experimental oncology 11 Gallen molecular subtype system , a surrogate for the ini- The Department of Oncology at Lund University began tial Perou–Sørlie classification of breast cancer, into lumi- assessing hormone receptor status and flow cytometric nal A-like, luminal B-like HER2-positive, luminal B-like S-phase fraction in fresh tumour tissue in the late HER2-negative, HER2-enriched and triple-negative sub- 1970s24,25. The assessment was implemented into clinical groups. Today, the St Gallen algorithm is used in clinical routine in the catchment area of the South Swedish Health decision-making, albeit imperfectly, to guide recommen- Care Region, and paved the way for adjuvant clinical trials dations for adjuvant systemic therapy based on predictive on the efficacy of adjuvant tamoxifen administered by biomarkers and risk of relapse. A question still of intense the South Swedish Breast Cancer Group (SSBCG)25.In debate is the cut-off between luminal A- and luminal B-like parallel with other national and international collaborative HER2-negative disease. It is presumed that a substantial groups, the SSBCG was established in 1977 as a collabo- number of these women, either node-negative or -positive, rative group between surgical departments at 15 hospitals treated with endocrine therapy for 5 years have a very low as well as oncologists, pathologists and radiologists, with risk of distant recurrence and should be spared overtreat- the goal of reducing inequality in delivery of care and ment with the addition of adjuvant chemotherapy. The promoting clinical trials of adjuvant therapy. In the early choice is often made on the basis of fraction of nuclear 2000s, routine analysis of hormone receptor status was 12 staining of Ki-67 . This distinction may be improved by shifted towards immunohistochemistry performed in the 1,13,14 multigene molecular assays , which are now being val- departments of pathology, and clinical trials were no 15 idated in large prospective studies . In many areas of the longer undertaken by professional collaborative groups. world, these specific multigene assays are already being The SSBCG continued its mission to promote best clinical applied in the decision-making process. care and diagnostics for patients, and supported continu- In Sweden, immunohistochemical/in situ hybridization ous collection of fresh tumour material in its biobank for assessment of ER, PR, Ki-67 and HER2 is now mandatory future diagnostics and as a research resource. Over time, for all patients with breast cancer, and reports on these new molecular techniques were set up in the Department biomarkers should be delivered within a short time frame of Oncology and introduced in a clinical setting. This was according to national guidelines. Compliance with these followed by early routine screening of inherited BRCA recommendations is monitored by the National Swedish gene mutations in familial breast and breast–ovarian Quality Register on Breast Cancer (INCA)16. However, cancer26. Such screening remains a national activity, but no laboratory-derived or commercially available genomic today these mutations are assessed by next-generation test has been approved by the Swedish National Board of sequencing (NGS) methods. In parallel, new methods Health17. and bioinformatics tools for tumour characterization were In addition to tumour-related biomarkers, inherited introduced, including microarray and NGS for genomic germline mutations in breast cancer susceptibility genes, and GEX profiling. However, facing
Load more

Recommended publications
  • Uppsala Academic Hospital Context Kildal
    Implementing High Value Care in Europe Implementing Value-Based Health Care in Europe Public hospitals Public Hospital Uppsala AcademicUppsala Academic Hospital Context Kildal. To increase efficiency, pathway coordinators were appointed to manage patient flows across departments Hospital Uppsala University Hospital is a large academic hospital with interprofessional teams focused on improvements in Sweden. With 8,300 employees and nearly 360,000 within units. Uppsala’s plan-do-study-act approach and outpatient visits annually[114], it provides highly specialised breakthrough programmes are now integral to a culture of care for complex and rare pathologies in a catchment area organisational change. Uppsala’s implementation Matrix is Context of over 2.2 million Swedes (20% of the population). In 2013, presented on the left. Uppsala launched its VBHC transformation plan. “With Uppsala University Hospital is a large academic the implementation of quality registries, we’ve had outcome hospital in Sweden. With 8,300 employees and nearly data for twenty years, but to achieve an in-depth, value- Internal forces 360,000 outpatient visits annually1, it provides highly driven transformation, you also need process,” said Professor specialised care for complex and rare pathologies in Morten Kildal, Lead for VBHC. This dialogue between process In 2015, Per Andersson, an Uppsala nurse, headed the a catchment area of over 2.2 million Swedes (20% and Achievementsoutcomes empowers teams to lead change across a ambulance unit and took over the dispatch centre, which had broad array of departments such as maternity, ambulance been outsourced to a private company. Andersson worked of the population). In 2013, Uppsala launched its Two years after launching its HVC programme, the and surgery.
    [Show full text]
  • Gofood 2017 in Lund-Copenhagen May 31–June 2 the 2Nd Global Food Safety & Technology Forum
    GoFood 2017 in Lund-Copenhagen May 31–June 2 The 2nd Global Food Safety & Technology Forum Invitation to GoFood 2017 We warmly invite you to the next global food safety conference, which will emphasize the need for joint global action within food safety. The inaugural conference was held in Hong Kong in February 2016 and the conference in 2017 will follow-up on the close collaborations between important global players in the field. The theme of the conference is: Challenges are global – So are the solutions! The conference and your valuable input and experience at this upcoming event will add to the understanding of the food safety challenges our world is facing as well as the possible global solutions. The conference will run from May 31 to June 2, 2017, and invited participants come from universities, global and regional authorities, NGO:s and industries. Themes are: Challenge: Do we get what we are paying for? Food authenticity and food fraud Challenge: Can we prioritize? Burden of disease from food Challenge: Can we share? Open access and pre-competition solutions Challenge: Food is traded globally – packaging and logistics Challenge: Time and Quality Challenge: Consumer Trust and New Challenges for the Retailers Challenge: Sustainable food production Challenge: Antimicrobial resistance and microbial food safety The conference is planned by the newly formed centre of excellence within global food safety together with collaborators around the world. The new Joint Centre of Excellence in Food Safety founded by the four universities: Lund University, National Food Institute – Technical University of Denmark, The Hong Kong Polytechnic University and University of Bologna.
    [Show full text]
  • Lundamats III Strategy for a Sustainable Transport System in Lund Municipality Foreword Contents
    LUNDAMATS III Strategy for a sustainable transport system in Lund Municipality Foreword Contents For a long time Lund Municipality has been working success- Page fully to take its transport system in an ever more sustainable 5 Why LundaMaTs III? direction. This work has attracted much attention at both People, traffic and sustainability in Lund national and international level. On many occasions the 6 Municipality has received awards for its work. 8 Future trends Since LundaMaTs II was adopted in 2006, the conditions 10 The transport system of the future for traffic and urban planning in Lund have changed. Lund 12 Six focus areas for a more sustainable is expanding, and its growing population and number of transport system in Lund businesses require more efficient use of its land and transport. 14 LundaMaTs’ targets The change in these conditions means that our approach and 15 LundaMaTs taken in context focus need updating in order to achieve long-term sustain- 16 Focus area 1 – Development of the villages able social development. LundaMaTs was therefore updated 18 Focus area 2 – A vibrant city centre during the autumn of 2013 and the winter of 2014, and on 7 May 2014 the City Council took the decision to adopt 20 Focus area 3 – Business transport LundaMaTs III. 22 Focus area 4 – Regional commuting LundaMaTs III will give our work clear direction over 24 Focus area 5 – A growing Lund the coming years and create favourable conditions for deve- 26 Focus area 6 – Innovative Lund lopment whereby the transport system will help ensure a better quality of life for all the residents, visitors and business operators in Lund.
    [Show full text]
  • Country Update, Sweden
    Proceedings World Geothermal Congress 2005 Antalya, Turkey, 24-29 April 2005 Country Update, Sweden Leif Bjelm Dept. of Engineering Geology, Lund Institute of Technology – Lund University. 20040722, Sweden [email protected] Keywords: Country update, Sweden Electric generation is therefore no choice and most of the geothermal energy ambitions are related to some kind of ABSTRACT heat pump combination. In Sweden there is only one geothermal plant in operation. Till around 1990 the funding kept coming and the research It is the geothermal heat pump plant established in Lund was quite active in Sweden. However the next coming ten and in operation since 1984. The plant is owned and years till around 2000 became dormant as the funding more operated by the public utility company, Lunds Energi AB. or less disappeared. But around 2000 new economical The geothermal heat pump plant deliver a base heat load to governmental resources became available when a new era the district heating network in the city corresponding to on the reduction of nuclear energy dependency was about 40% of the energy heat demand. introduced. This is where we stand today with a number of activities around the country but only two of them are right There are two new geothermal projects under exploration now related to commercial realities. and completion in Sweden. Both are in Scania in southernmost Sweden. In Malmö a COMMERCIAL OUTCOME OF THE NATIONAL private energy company, Sydkraft AB, drilled two wells EFFORTS SO FAR during 2002 and 2003. Tests are scheduled to be finished In Sweden there is only one commercial geothermal spring 2004.
    [Show full text]
  • Bridging the Gap-The Use of Methods from Research Results For
    Bridging the gap - the use of methods from research results for implementation of Sustainable Urban Transport Plans – with the example from Lund, Sweden Christer Ljungberg, Dr Eng, CEO, Trivector Traffic, Lund, Sweden 1. The concept of sustainable transport systems in Sweden The discussion of climate change and environmental problems has accelerated during 2006. In Europe the discussion about sustainability has been ongoing since beginning of the nineties. Already in 1996 a cooperation of several Swedish transport authorities and organisations (National Road Administration, The Swedish Association of Local Authorities and Regions, National Board of Housing, Building and Planning, Rail Infrastructure Authority, The Car Industry Cooperation together with the Swedish Environmental Protection Agency), published a series of reports regarding “Environmental Adapted Transport Systems”, in Swedish called MaTs (MiljöAnpassade TransportSystem). The MaTs concept is built upon The Four Environmental System Conditions of The Natural Step organisation: 1) Substances from the Earth’s crust must not systematically increase in the ecosphere 2) Substances produced by society must not systematically increase in the ecosphere 3) The physical basis for productivity and diversity of nature must not be systematically diminished 4) Fair and efficient use of resources with respect to meeting human needs. In the concept the measures for sustainability are divided into 5 areas: 1) Measures influencing the travel need 2) Measures influencing modal split and intermodality 3) Measure influencing operation of the different transport modes 1 4) Technical measures on vehicles and fuels 5) Measures influencing building, operation and maintenance of infrastructure This concept, MaTs, has been used and discussed in several governmental bills, regarding infrastructure, transport, environment and climate.
    [Show full text]
  • National Phd Course: Economic Geography (7.5 ECTS Credits), Lund, Göteborg and Uppsala, Sweden, September–November 2013
    National PhD Course: Economic Geography (7.5 ECTS Credits), Lund, Göteborg and Uppsala, Sweden, September–November 2013 Organizers Jerker Moodysson & Lars Coenen, Lund University Patrik Ström & Anja Franck, Göteborg University Jenny Sjöholm & Johan Jansson, Uppsala University (co-ordinators) Course description The course is jointly arranged by economic geographers at the universities of Lund, Göteborg and Uppsala. It builds on a format developed during previous courses on the same theme, held every second year since 1997. The course offers an introduction to contemporary research perspectives and approaches in economic geography. While it primarily targets PhD students working on theses within economic geography, the course is designed to be accessible also to PhD students in human geography generally, as well as in related economic and social science disciplines. PhD students affiliated with Swedish geography departments taking part in the national collaboration on PhD courses in human geography are given priority, but also students from other universities in Sweden and beyond will be accepted if there are slots available. We aim at getting 15-25 students in the course. The course will be taught in English. The course introduces research questions, concepts and theories in contemporary economic geography as well as examples of ongoing empirical research. The core questions of economic geography– related to the role of place and space in processes of economic development – have in recent years attracted interest not just from geographers
    [Show full text]
  • Skåne's Regional Development Strategy
    SKÅNE'S REGIONAL DEVELOPMENT STRATEGY Skåne's Regional Development Strategy June 2014 Political Steering Group: Pia Kinhult, Katarina Erlingson, Rikard Larsson, Pontus Lindberg, Ewa Bertz, Christine Axelsson, Carl Johan Sonesson, Anders Åkesson, Henrik Fritzon, Yngve Petersson, Birgitta Södertun, Stefan Lamme, Vilmer Andersen and Lars-Johan Hallgren, representatives from the Regional Executive Committee, the Regional Growth Committee and the Healthcare Committee within Region Skåne. Political Secretaries: Sofia Nerbrand, Mattias Olsson, Jacqueline Doohan, Jonas Duveborn, Emelie Larsson, Mattias Svensson and Stefan Brandt, Region Skåne. Project Manager: Mikael Stamming, Region Skåne. Project Group: Therese Andersson, Sarah Ellström, Ola Jacobson, Eskil Mårtensson, Richard Gullstrand, Patrik Lindblom, Carina Nordqvist Falk, Christina Ståhl, Thomas Nilsson and Gudmundur Kristjansson, Region Skåne. Layout: Dockside Reklambyrå AB. Photos: Jörgen Johansson, Niklas Forshell. Published by: Region Skåne 2014. Adopted by the Regional Council on 17 June 2014 www.skane2030.se 2 Let us open up Skåne together What you have in your hand is Skåne's regional development strategy, the result of extensive dia- logues with citizens, civil society, business, and the public sector. We are now gathering around a joint strategic objective to achieve an open Skåne by 2030. An open Skåne that welcomes plural- ism, more people and new ideas. A Skåne that is characterised by high tolerance and widespread participation in common social issues. The open Skåne encompasses an open landscape as well as urbanisation. The open Skåne breaks national boundaries and is a natural part of the Öresund Region. The open Skåne offers everyone the chance of a good life. Together we have also selected five prioritised areas that we need to work with in order to achieve a completely open Skåne: Skåne shall offer optimism and quality of life, be a strong, sus- tainable growth engine, benefit from its polycentric urban structure, develop the welfare services of tomorrow and be globally attractive.
    [Show full text]
  • Municipal Finance in Sweden
    FACTSHEET April 2021 Municipal Finance in Sweden Fedra Vanhuyse, Stockholm Environment Institute Astrid Nilsson, Stockholm Environment Institute Venni Arra, Stockholm Environment Institute Alicia Requena, Cleantech Scandinavia Magnus Agerström, Cleantech Scandinavia For most Swedish citizens, their closest engagement with the Funding of Swedish municipalities government happens through the municipalities they live in. In Sweden, there are 290 municipalities that are responsible In Sweden, a municipality’s revenue mostly comes from taxes, for providing its inhabitants with numerous services, including fees for certain services and government grants. Municipal tax is education and childcare, non-medical health care, social care, the main source of revenue. For all residents in Sweden to have waste and water treatment, and environmental management. access to equal services, regardless of where they live, there is a tax equalization system, in which differences in tax revenues and This factsheet offers some introductory insights into how expenditure needs are balanced so that all municipalities have municipal governments are financed and what their budgets approximately the same tax base, I.e., revenue per inhabitant. entail. It draws upon research carried out by the Viable Cities’ It works in two ways: 1) on the revenue side, it evens out the Finance project. This project assesses how cities can fund differences in tax base per capita and 2) on the expenditures side, their investments in sustainability. We provide examples of it distributes funds and grants to local governments with adverse nine Swedish municipalities: Gothenburg, Linköping, Lund, cost structures and unfavourable demographic compositions. Malmö, Nacka, Örebro, Östersund, Västerås and Vellinge. Other income sources include financial results such as interest These cities were selected as they have issued a green bond, rates on funds in the bank and on loans.
    [Show full text]
  • A Study of 11 Large Municipalities in Sweden
    Sustainable mobility in the Sustainable City – a study of 11 large municipalities in Sweden Final Report. Project 15-549 Author: Paul Fenton Division of Environmental Technology & Management, Linköping University, 58183 Linköping, Sweden. Tel: +46 13 285620, Fax: +46 13 281101, Email: [email protected] Summary The report presents findings from a qualitative study of strategy and policy processes for sustainable mobility and sustainable transport in eleven large municipalities in Sweden. The findings are presented thematically and with reference to interviews in each of the municipalities. The main conclusions of the report are that organisational design and the extent to which external stakeholders are involved in municipal processes are important influences on outcomes; political will and the presence of committed individuals is vitally important; and that municipalities are hamstrung by ineffective national planning processes. Acknowledgements The author wishes to thank the funders of both phases of the project for their interest and support – for Phase I, Riksbyggens Jubileumsfond Den Goda Staden; the Swedish national innovation agency Vinnova through its programme “Verifiering för samverkan”; Göteborg Energis Stiftelse för forskning och utveckling; and for Phase II, J. Gust. Richerts stiftelse; and ÅForsk. In addition, thank you to the many individuals who have contributed directly or indirectly to this study, including Agnes Rönnblom, Prosper Chipato, Tanaka Mukoko, Jenny Ohlsson Orell, Karolin Ring, and Tove Nordberg. In particular,
    [Show full text]
  • Pre-Arrival Guide for Formal Exchange Students Spring 2021
    1 PRE-ARRIVAL GUIDE FOR FORMAL EXCHANGE STUDENTS SPRING 2021 Pre-Arrival Guide SPRING 2021 | PLANNING YOUR STAY AS A FORMAL EXCHANGE STUDENT 2 PRE-ARRIVAL GUIDE FOR FORMAL EXCHANGE STUDENTS SPRING 2021 Welcome to Lund University! We are delighted that you are planning to study at Lund University, a non-profit Swedish university and one of Europe’s broadest and finest. We combine a tradition of excellence dating back to 1666 with cutting-edge research and innovation. Choosing to study at Lund University is your first step to an interna- tional career. As a student, you will benefit from the opportunity to tap into a global network of contacts among fellow students, university staff and researchers alike – a valuable asset for your future. As you prepare for your studies at Lund University, the questions you face may seem endless. Where do I go when I arrive? What do I need to know about residence permits, health insurance or mobile phone operators? With this pre-arrival guide we aim to answer these questions to help make your transition abroad as smooth and informed as possible. If you read this guide carefully, you will find answers to many of your questions. We hope that your stay at Lund University will be an interesting and rewarding experience both for you and for us. We are looking forward to meet you soon! 3 PRE-ARRIVAL GUIDE FOR FORMAL EXCHANGE STUDENTS SPRING 2021 Table of contents Lund University - a world class university 4 One university - three campuses 5 Residence permits for studies 7 Student accommodation 9 Hostels and hotels 12 Travelling to Lund University 13 Arrival Day at Lund University 15 The Orientation Weeks for exchange students 16 Financial matters 19 Insurance and health care 21 Your studies 23 Student life in Lund 25 Sweden 27 Living in Sweden 29 Check-list and Academic Calendar 31 Contact details 32 4 PRE-ARRIVAL GUIDE FOR FORMAL EXCHANGE STUDENTS SPRING 2021 Lund University - a world class university At Lund, history and tradition lay the foundation for the study and research environments of tomorrow.
    [Show full text]
  • MUNICIPAL FACTS Lomma 99 118 119 182 26 20 Bjärred 7 7 8 7 12 Total 106 125 127 189 38
    5 RESIDENCE AND HOUSEHOLDS 2000 2005 Resi- House- Residence/ Resi- House- Residence/ District dence hold Household dence hold Household Lomma 8 718 3 764 2,32 9 251 3 944 2,35 Bjärred 9 051 3 496 2,59 9 343 3 594 2,60 Total 17 769 7 260 2,45 18 594 7 538 2,47 2010 2019 Resi- House- Residence/ Resi- House- Residence/ District dence hold Household dence hold Household Lomma 11 148 4 631 2,41 13 910 5 731 2,43 Bjärred 10 116 3 843 2,63 10 604 3 959 2,68 Total 21 264 8 474 2,51 24 514 9 690 2,53 6 HOUSING 2018 – TYPE OF HOUSING Number of households by household types District Domestic housing Multi dwelling housing Total Lomma 2 984 2 874 5 858 Bjärred 3 326 720 4 046 Total 6 310 3 594 9 904 7 HOUSING 2018 - TENURE STATUS Number of households by household types District Ownership Tenant Leasing Total Lomma 2 676 2 566 616 5 858 Bjärred 3 292 472 282 4 046 Total 5 968 3 038 898 9 904 8 NEW HOUSING Number of new constructed dwellings (apartments) District 2015 2016 2017 2018 2019 MUNICIPAL FACTS Lomma 99 118 119 182 26 20 Bjärred 7 7 8 7 12 Total 106 125 127 189 38 1 GENERAL DESCRIPTION 9 EMPLOYMENT AND COMMUTING 2018 The municipal district of Lomma is located on the Öresund coast, north of the Economically Work and Commute Commute city of Malmö. The municipality was created in January 1963, when the urban active live in the to another from another district of Lomma and the rural district of Flädie was amalgamated.
    [Show full text]
  • Mobile Lab on Sharing in Gothenburg
    Mobile Lab on Sharing in Gothenburg Voytenko Palgan, Yuliya; Mccormick, Kes; Leire, Charlotte; Lund, Tove; Öhrwall, Emma; Sandoff, Anders; Williamsson, Jon 2020 Document Version: Publisher's PDF, also known as Version of record Link to publication Citation for published version (APA): Voytenko Palgan, Y., Mccormick, K., Leire, C., Lund, T., Öhrwall, E., Sandoff, A., & Williamsson, J. (2020). Mobile Lab on Sharing in Gothenburg. Lund University. Total number of authors: 7 General rights Unless other specific re-use rights are stated the following general rights apply: Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Read more about Creative commons licenses: https://creativecommons.org/licenses/ Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. LUND UNIVERSITY PO Box 117 221 00 Lund +46 46-222 00 00 Mobile Lab on Sharing in Gothenburg Yuliya Voytenko Palgan, Kes McCormick, Charlotte Leire, Tove Lund, Emma Öhrwall, Anders Sandoff, and Jon Williamsson Mobile Lab Report International Institute for Industrial Environmental Economics (IIIEE), Lund University Lund, Sweden, February 2020 Mobile Lab on Sharing in Gothenburg | 2 Funded by the Swedish Research Council Formas, the aim of the Sharing and the City project is to examine, test and advance knowledge on the role of municipalities in the initiation, implementation and institutionalisation of sharing organisations across cities in Europe.
    [Show full text]