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Supplemental Material.Pdf Decreased rCBF with 60mg bid SYN115 See legend at bottom of table. cluster-level voxel-level atlas location pFWE-corr qFDR-corr kE puncorr pFWE-corr qFDR-corr T Zequiv puncorr Xmm Ymm Zmm cluster # VOI Nearest gray matter according to Talairach Daemon (last number = distance in mm) 1 0.000 0.000 1387 0.000 0.000 0.005 19.51 6.17 0.000 10.5 -21 12 1 Right Cerebrum,Sub-lobar,Thalamus,Gray Matter,Medial Dorsal Nucleus,0 0.000 0.016 15.36 5.75 0.000 -7.5 -18 12 2 Left Cerebrum,Sub-lobar,Thalamus,Gray Matter,Medial Dorsal Nucleus,0 0.001 0.029 12.91 5.44 0.000 13.5 -66 36 3 Right Cerebrum,Parietal Lobe,Precuneus,Gray Matter,Brodmann area 7,1 0.005 0.059 11.37 5.20 0.000 1.5 -60 21 Right Cerebrum,Occipital Lobe,Precuneus,Gray Matter,Brodmann area 23,1 0.006 0.063 11.00 5.14 0.000 19.5 -72 39 Right Cerebrum,Parietal Lobe,Precuneus,Gray Matter,Brodmann area 7,1 0.023 0.111 9.68 4.89 0.000 10.5 -36 -12 midbrain, edge of brain 0.034 0.121 9.32 4.81 0.000 -4.5 -33 -3 4 midbrain (superior colliculus per Mai atlas) 0.039 0.121 9.20 4.79 0.000 -7.5 -24 6 Left Cerebrum,Sub-lobar,Thalamus,Gray Matter,Pulvinar,0 0.077 0.166 8.56 4.65 0.000 1.5 -69 18 5 Right Cerebrum,Occipital Lobe,Precuneus,Gray Matter,Brodmann area 31,1 0.088 0.167 8.45 4.62 0.000 10.5 -48 -6 Right Cerebellum,Anterior Lobe,Culmen,Gray Matter,*,0 0.109 0.167 8.27 4.57 0.000 4.5 -27 -15 6 midbrain (pons near SNr, per Mai atlas) 0.114 0.167 8.23 4.56 0.000 -7.5 -69 51 Left Cerebrum,Parietal Lobe,Precuneus,Gray Matter,Brodmann area 7,2 0.298 0.262 7.43 4.36 0.000 -4.5 -27 -12 midbrain (SNr, per Mai atlas) 0.532 0.303 6.98 4.23 0.000 7.5 -51 18 7 Right Cerebrum,Limbic Lobe,Posterior Cingulate,Gray Matter,Brodmann area 30,1 0.734 0.331 6.66 4.13 0.000 -7.5 -45 18 Left Cerebrum,Limbic Lobe,Posterior Cingulate,Gray Matter,Brodmann area 29,1 0.762 0.349 6.57 4.10 0.000 7.5 -69 51 Right Cerebrum,Parietal Lobe,Precuneus,Gray Matter,Brodmann area 7,1 0.787 0.365 6.49 4.08 0.000 -4.5 -54 -6 Left Cerebellum,Anterior Lobe,Culmen,Gray Matter,*,0 0.810 0.381 6.41 4.05 0.000 -13.5 -66 39 Left Cerebrum,Parietal Lobe,Precuneus,Gray Matter,Brodmann area 7,2 0.881 0.435 6.14 3.97 0.000 -13.5 -72 33 Left Cerebrum,Occipital Lobe,Cuneus,Gray Matter,Brodmann area 7,0 0.910 0.442 6.01 3.92 0.000 -16.5 -45 -3 Left Cerebrum,Occipital Lobe,Lingual Gyrus,Gray Matter,Brodmann area 19,1 0.958 0.509 5.73 3.82 0.000 7.5 -84 12 Right Cerebrum,Occipital Lobe,Cuneus,Gray Matter,Brodmann area 18,0 0.965 0.509 5.67 3.80 0.000 4.5 -30 18 Right Cerebrum,Limbic Lobe,Posterior Cingulate,Gray Matter,Brodmann area 23,4 0.990 0.597 5.34 3.67 0.000 -19.5 -75 51 Left Cerebrum,Parietal Lobe,Precuneus,Gray Matter,Brodmann area 7,2 0.992 0.608 5.29 3.66 0.000 4.5 -78 3 Right Cerebrum,Occipital Lobe,Lingual Gyrus,Gray Matter,Brodmann area 18,0 0.997 0.670 5.09 3.57 0.000 31.5 -69 48 Right Cerebrum,Parietal Lobe,Superior Parietal Lobule,Gray Matter,Brodmann area 7,2 1.000 0.807 4.59 3.36 0.000 31.5 -60 60 Right Cerebrum,Parietal Lobe,Superior Parietal Lobule,Gray Matter,Brodmann area 7,3 1.000 0.871 4.47 3.31 0.000 19.5 -54 15 Right Cerebrum,Limbic Lobe,Posterior Cingulate,Gray Matter,Brodmann area 30,2 1.000 0.977 4.17 3.16 0.001 13.5 -66 0 Right Cerebrum,Occipital Lobe,Lingual Gyrus,Gray Matter,Brodmann area 18,1 2 0.000 0.000 327 0.000 0.000 0.018 14.27 5.62 0.000 7.5 45 9 8 Right Cerebrum,Limbic Lobe,Anterior Cingulate,Gray Matter,Brodmann area 32,0 0.138 0.180 8.06 4.52 0.000 7.5 39 21 Right Cerebrum,Limbic Lobe,Anterior Cingulate,Gray Matter,Brodmann area 32,2 0.332 0.269 7.35 4.34 0.000 7.5 30 33 9 Right Cerebrum,Frontal Lobe,Medial Frontal Gyrus,Gray Matter,Brodmann area 9,0 0.410 0.297 7.18 4.29 0.000 19.5 54 6 Right Cerebrum,Frontal Lobe,Superior Frontal Gyrus,Gray Matter,Brodmann area 10,4 0.552 0.303 6.95 4.22 0.000 -16.5 33 27 Left Cerebrum,Frontal Lobe,Medial Frontal Gyrus,Gray Matter,Brodmann area 9,0 0.563 0.303 6.94 4.22 0.000 -10.5 42 9 Left Cerebrum,Limbic Lobe,Anterior Cingulate,Gray Matter,Brodmann area 32,1 0.851 0.424 6.26 4.01 0.000 -4.5 45 0 Left Cerebrum,Limbic Lobe,Anterior Cingulate,Gray Matter,Brodmann area 32,0 0.999 0.745 4.94 3.51 0.000 -4.5 45 -12 10 Left Cerebrum,Frontal Lobe,Medial Frontal Gyrus,Gray Matter,Brodmann area 11,0 1.000 0.790 4.74 3.43 0.000 -19.5 51 15 Left Cerebrum,Frontal Lobe,Superior Frontal Gyrus,Gray Matter,Brodmann area 10,3 1.000 0.888 4.43 3.29 0.001 4.5 36 -3 Right Cerebrum,Limbic Lobe,Anterior Cingulate,Gray Matter,Brodmann area 32,0 3 0.000 0.000 263 0.000 0.026 0.111 9.59 4.87 0.000 -19.5 12 33 11 Left Cerebrum,Limbic Lobe,Cingulate Gyrus,Gray Matter,Brodmann area 32,3 0.068 0.164 8.68 4.67 0.000 -28.5 21 39 12 Left Cerebrum,Frontal Lobe,Middle Frontal Gyrus,Gray Matter,Brodmann area 8,1 0.649 0.315 6.83 4.19 0.000 -49.5 24 18 Left Cerebrum,Frontal Lobe,Inferior Frontal Gyrus,Gray Matter,Brodmann area 45,0 0.697 0.318 6.77 4.17 0.000 -49.5 33 9 Left Cerebrum,Frontal Lobe,Inferior Frontal Gyrus,Gray Matter,Brodmann area 46,3 0.864 0.433 6.21 3.99 0.000 -46.5 21 30 Left Cerebrum,Frontal Lobe,Middle Frontal Gyrus,Gray Matter,Brodmann area 9,1 0.986 0.569 5.42 3.71 0.000 -49.5 18 9 Left Cerebrum,Frontal Lobe,Precentral Gyrus,Gray Matter,Brodmann area 44,0 0.996 0.670 5.14 3.60 0.000 -34.5 27 12 Left Cerebrum,Frontal Lobe,Inferior Frontal Gyrus,Gray Matter,Brodmann area 13,5 1.000 0.910 4.29 3.22 0.001 -28.5 33 9 No Gray Matter found,,,,, Decreased rCBF with 60mg bid SYN115 See legend at bottom of table. cluster-level voxel-level atlas location pFWE-corr qFDR-corr kE puncorr pFWE-corr qFDR-corr T Zequiv puncorr Xmm Ymm Zmm cluster # VOI Nearest gray matter according to Talairach Daemon (last number = distance in mm) 4 0.000 0.000 235 0.000 0.204 0.223 7.74 4.44 0.000 -46.5 6 51 13 Left Cerebrum,Frontal Lobe,Middle Frontal Gyrus,Gray Matter,Brodmann area 6,0 0.281 0.262 7.48 4.37 0.000 -22.5 -12 54 Left Cerebrum,Frontal Lobe,Middle Frontal Gyrus,Gray Matter,Brodmann area 6,1 0.882 0.435 6.14 3.97 0.000 -40.5 -18 66 Left Cerebrum,Frontal Lobe,Precentral Gyrus,Gray Matter,Brodmann area 6,4 0.891 0.435 6.10 3.95 0.000 -25.5 3 57 Left Cerebrum,Frontal Lobe,Sub-Gyral,Gray Matter,Brodmann area 6,1 0.956 0.509 5.74 3.83 0.000 -10.5 12 54 Left Cerebrum,Frontal Lobe,Superior Frontal Gyrus,Gray Matter,Brodmann area 6,2 0.957 0.509 5.74 3.82 0.000 -25.5 -9 42 Left Cerebrum,Frontal Lobe,Middle Frontal Gyrus,Gray Matter,Brodmann area 6,1 0.998 0.705 5.01 3.54 0.000 -10.5 0 57 Left Cerebrum,Frontal Lobe,Medial Frontal Gyrus,Gray Matter,Brodmann area 6,2 1.000 0.790 4.73 3.42 0.000 -34.5 3 45 Left Cerebrum,Frontal Lobe,Middle Frontal Gyrus,Gray Matter,Brodmann area 6,3 1.000 0.807 4.57 3.35 0.000 -31.5 -3 39 Left Cerebrum,Frontal Lobe,Precentral Gyrus,Gray Matter,Brodmann area 6,3 1.000 0.887 4.45 3.30 0.000 -31.5 -24 63 Left Cerebrum,Frontal Lobe,Precentral Gyrus,Gray Matter,Brodmann area 4,0 5 0.000 0.000 75 0.000 0.660 0.315 6.81 4.18 0.000 34.5 -36 60 14 Right Cerebrum,Parietal Lobe,Postcentral Gyrus,Gray Matter,Brodmann area 2,0 0.956 0.509 5.74 3.83 0.000 25.5 -27 69 Right Cerebrum,Parietal Lobe,Postcentral Gyrus,Gray Matter,Brodmann area 3,3 6 0.000 0.000 75 0.000 0.718 0.326 6.71 4.15 0.000 -28.5 -60 63 15 Left Cerebrum,Parietal Lobe,Superior Parietal Lobule,Gray Matter,Brodmann area 7,3 0.987 0.569 5.40 3.70 0.000 -37.5 -63 48 Left Cerebrum,Parietal Lobe,Superior Parietal Lobule,Gray Matter,Brodmann area 7,0 1.000 0.807 4.61 3.37 0.000 -16.5 -54 54 Left Cerebrum,Parietal Lobe,Precuneus,Gray Matter,Brodmann area 7,1 1.000 0.829 4.53 3.33 0.000 -31.5 -69 45 Left Cerebrum,Parietal Lobe,Superior Parietal Lobule,Gray Matter,Brodmann area 7,1 7 0.780 0.264 8 0.088 0.906 0.442 6.03 3.93 0.000 -34.5 -87 6 Left Cerebrum,Occipital Lobe,Middle Occipital Gyrus,Gray Matter,Brodmann area 19,0 8 0.992 0.514 3 0.283 0.940 0.506 5.85 3.86 0.000 28.5 21 57 Right Cerebrum,Frontal Lobe,Middle Frontal Gyrus,Gray Matter,Brodmann area 6,0 9 0.992 0.514 3 0.283 0.959 0.509 5.72 3.82 0.000 -34.5 -45 -9 Left Cerebrum,Occipital Lobe,Fusiform Gyrus,Gray Matter,Brodmann area 37,0 10 0.946 0.406 5 0.169 0.960 0.509 5.71 3.82 0.000 -13.5 -78 12 16 Left Cerebrum,Occipital Lobe,Cuneus,Gray Matter,Brodmann area 17,0 11 0.845 0.309 7 0.108 0.963 0.509 5.69 3.81 0.000 -13.5 -51 9 Left Cerebrum,Limbic Lobe,Posterior Cingulate,Gray Matter,Brodmann area 30,0 12 0.396 0.176 14 0.029 0.966 0.509 5.66 3.80 0.000 25.5 -9 54 Right Cerebrum,Frontal Lobe,Middle Frontal Gyrus,Gray Matter,Brodmann area 6,0 13 0.641 0.223 10 0.060 0.972 0.525 5.61 3.78 0.000 -7.5 18 36 Left Cerebrum,Limbic Lobe,Cingulate Gyrus,Gray Matter,Brodmann area 32,2 1.000 0.807 4.62 3.37 0.000 -7.5 15 45 Left Cerebrum,Frontal Lobe,Medial Frontal Gyrus,Gray Matter,Brodmann area 6,2 14 0.509 0.212 12 0.041 0.977 0.539 5.55 3.76 0.000 37.5 -33 -9 17 Right Cerebrum,Limbic Lobe,Parahippocampal Gyrus,Gray Matter,Brodmann area 36,2 1.000 0.910 4.35 3.25 0.001 37.5 -18 -15 Right Cerebrum,Temporal Lobe,Sub-Gyral,Gray Matter,Brodmann area 20,4 15 0.020 0.010 37 0.001 0.984 0.568 5.45 3.72 0.000 13.5 -15 63 18 Right Cerebrum,Frontal Lobe,Precentral Gyrus,Gray Matter,Brodmann area 6,2 1.000 0.915 4.27 3.21 0.001 13.5 -12 51 Right Cerebrum,Frontal Lobe,Medial Frontal Gyrus,Gray Matter,Brodmann area 6,0 16 0.203 0.088 19 0.013 0.986 0.569 5.42 3.71 0.000 25.5 24 36 Right Cerebrum,Frontal Lobe,Middle Frontal Gyrus,Gray Matter,Brodmann area 8,2 17 0.992 0.514 3 0.283 0.992 0.608 5.30 3.66 0.000 4.5 -30 63 Right Cerebrum,Frontal Lobe,Paracentral Lobule,Gray Matter,Brodmann area 6,0 18 0.901 0.367 6 0.134 0.997 0.670 5.13 3.59 0.000 7.5 24 51 Right Cerebrum,Frontal
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