GMP LIST OF CONTENTS: Infusion therapy Antiseptics and irrigation solutions RHeosorbilact® 8 Latren® 8 Decasan® 17 Soda-Bufer® 9 CYTOCLIN® 17 XYlat® 9 Turusol® 18 Tivortin® 10 Horosten® 18 GiK® 10 GeCoTON® 11 GeCodeS® 11 SorbilaCt® 12 AminocaproNic acid, sol. 5% 12 ANTIBACTERIAL AND FAMOZOL® 13 FUNGICIDAL DRUGS SUFER® 13 Leflocin® 19 Leflocin® 750 19 SIMPLEX INFUSION Bigaflon® 20 SOLUTIONS Ofloxacin 20 MAXICIN® 21 sol. 0,9% 14 LINELID® 21 Water for injection 14 Ornigil® 22 sol. 5% 14 Ciprofloxacin 22 14 Soluseptol® 23 Ringer's sol. 15 METRONIDAZOLE 23 Ringer's-lactate sol. 15 FLUCONAZOLE 24 Sodium hydrocarbonate sol. 4% 15 FLUCONAZOLE 400 mg 24 Mannit, 15% 16 Polyglucin 16 Rheopolyglucin 16

2 cartilage modifying ANALGESICS AND ACCESSORIES FOR Drugs ANAESTHETICS INFUSION THERAPY

Hyalual®-artro 25 LONGOCAIN® 30 SOLUVEN® 35 LONGOCAIN® HEAVY 30 Syringes with two needles 36 NOVOCAINE, sol. 0,25%, 0,5% 30 I.V. SETS (PS and PB) 36 INFULGAN® 31 ORAL Solutions COMPRESSOR Lactuvit® 26 Tivortin® Aspartate 27 NEBULIZERS «ULAIZER» Ulaizer® Pro 37 Clinical Ulaizer® Home 37 Ulaizer® First Aid 37 Aminol® 32 GluXyl® 32 ANTI-TUBERCULOSIS DRUGS FOR NEBULIZER THERAPY Isoniazid syrup 28 ANTIVIRAL DRUGS DECASAN® 38 RIFONAT 28 ® SODIUM CHLORIDE 38 Inbutol® 29 NEBUTAMOL® 38 Paskonat® 29 АКК® 33 NEBUFLUZON® 38 BITUB® 29

DIALYSIS SOLUTIONS Drugs for treatment of wounds and ulcers

DIAVITEC® PD 34 LACERTA® 39

3 "YURiA-PHARM" – a dynamically The total headcount of "YURiA-PHARM" is constantly growing growing company and at the moment, it exceeds 1000, 2/3 of them being involved in production and R&D. Founded in 1998, "YURiA-PHARM" focused its efforts towards the production of infusions and as of today, "YURiA-PHARM" is the leading infusion manufacturer not only in Ukraine, but "YURiA-PHARM" – a wide range of popular also in CIS. We supply medical facilities with more than 100 original and generic infusion preparations items of - and plasma substitute solutions, original Our company produces a number of medications (original infusion drugs, antibiotics, fungicidal drugs, syrups, antiseptics, and generic), which are not produced in CIS countries – parenteral nourishment medications, anti-tuberculosis drugs, RHEOSORBILACT®, SORBILACT®, DECASAN®, HOROSTEN® etc. syringes and I.V. sets. Our product line sums up to more For instance, RHEOSORBILACT® (30% of the total distribution than 40 infusions, completely covering the needs of medical of the medications included in B 05 ATC code (B05 - Blood facilities with infusion therapy medications. The annual substitutes and perfusion solutions) and SORBILACT® turnover of our company exceeds 60 mln bottles. constitute the basis of infusion therapy in Ukraine. They have completely replaced polyvinylpyrrolidone medications (such "YURiA-PHARM" confidently takes a as Hemodez, Neohemodez etc.) prohibited in many European leading position in the export markets and other countries, and solutions, whose usage is We deliver our products to Russia, Moldova, Kazakhstan, restricted. Uzbekistan, Azerbaijan, Tajikistan, Kirgizia, Turkmenistan and In our portfolio we also have unique cosmetic therapeutic Georgia. More than 100 items are now being registered for products – HYALUAL® (an anti-age therapy, helps keep the usage in different countries and the number is continuously skin young and healthy for a long time), cartilage modifying growing. injectable drug – HYALUAL®-ARTRO – a unique innovative In 2008, "YURiA-PHARM" Corporation has received a Certificate cartilage protective of a new generation. It is of compliance to international quality management standards an effective combination of hyaluronic acid and sodium ISO 9001 (9001:2009). In 2011 "YURiA-PHARM" Corporation succinate for the treatment of osteoarthritis. was GMP certified.

4 "YURiA-PHARM" – appreciated by the At the moment our products are released in 9 forms, including physitians and the scientific medical prefilled syringes, nebules, bags for irrigation solutions, community polypropylene bags, PVC bags, glass bottles and plastic bottles.

We cooperate intensively with many research institutions in "YURiA-PHARM" – a right hand of any the field. For the first time in CIS, in collaboration with the physician Hematologic Pathology and Transfusion Medical Institute of Ukraine's Academy of Medical Science, we have developed Our medications accelerate the patients' recovery due to their a group of complex multifunctional infusion solutions – higher efficiency, considerable decrease of complications RHEOSORBILACT®, SORBILACT® and XYLAT®, which today and minimal side-effects. Numerous reputable medical represent the basis of a new domain in internal medicine– investigations have proven a visible time saving factor in Restricted-volume infusion therapy. Our corporation inpatient treatment as well as a higher therapeutic comfort conducts an intensive researches with new medications as level. These factors reduce treatment cost and increase the well as examines more deeply the capacity of the existing average annual bed turnover. ones. We make large investments in Research & Development to help prove the quality and efficiency of our medications "YURiA-PHARM" – a reliable and according to the requirements of the “case-based medicine”. advantageous partner

"YURiA-PHARM" – constant improvement According to a broad experience, the practical usage of of production according to market medications manufactired by "YURiA-PHARM" have in general, requirements enhanced the overall image of both medical facilities and Keeping in mind the constant enhancing of quality and physicians. accessibility of treatment, we improve the forms and dosages of the medications on a permanent basis. Uncompromising quality and reasonable pricing have made our medications the bestsellers in Ukraine and in the CIS and we have every reason to expect similar success in other countries.

5 "YURiA-PHARM" Facts:

• leader in the production of infusion solutions; • more than 40% annual growth rate; • more than 100 items in the product line; • total headcount (employees) exceed 1000; • annual turnover up to 60 million units; • exports to 17 countries; • 80% of annual net profit is invested in the modernization of production; • each year about 10-15 new medical products are released each year; • presence of an operational quality control system ISO 9001: 2009; • GMP-certified manufacturer.

6 "YURiA-PHARM" Corporate philosophy

OUR PURPOSE OUR VISION Life is the greatest value of all! We are a leading specialized pharmaceutical corporation, Our calling is to preserve and improve it! and the best employer in the market.

OUR MISSION OUR VALUES • We create unique solution for health care and treatment. • The trust of our Partners • We earn the respect of our Community, recognition of our • We are an ambitious team of professionals united by our Doctors and the trust of our Patients. corporate spirit • We engage the creative potential of our Employees and • Supreme product quality Partner and increase their welfare. • Superior level of Client interaction • Our innovations shape the style of the pharmaceutical • Effective internal communication business. • Maximum performance and high profitability • Self-actualization of each Employee

7 INFUSION THERAPY

RHEOSORBILACT® LATREN®

Number One Enhanced infusion therapy drug microcirculatory effect Ukraine’s research heritage

2009

How supplied: How supplied: 200 ml and 400 ml glass bottles 100 ml and 200ml glass bottles

RHEOSORBILACT® is a polyfunctional electrolytic balance correction, mild metabolic LATREN® is an infusion solution with a balanced hyperosmolar drug. The rational combination acidosis correction and hepatoprotective isoosmolar electrolyte solution (Ringer's lactate of components that complement and action. RHEOSORBILACT® is the foundation of solution) which potentiates the effect of potentiate each other, allowing the Restricted-volume infusion therapy, a modern pentoxifylline. Effective for both peripheral and achievement of a polyfunctional effect: branch of internal medicine. brain circulatory disorders. hemodynamics stabilization, pronounced LATREN® is supplied as a final dosage form, detoxication effect, improved microcirculation therefore eliminating the risk of technical error or and blood rheological properties, hydro- solution infection.

8 INFUSION THERAPY

SODA-BUFER® XYLAT®

Buffered Infusion therapy sodium for diabetes hydrocarbonate mellitus and solution ketosis of different genesis

How supplied: How supplied: 100 ml, 200 ml and 20 ml glass bottles 200 ml and 400 ml glass bottles

The use of SODA-BUFER® is This ensures the exceptional safety A multicomponent hyperosmolar solution pronounced antiketogenic action. recommended for diseases of this drug. containing xylytol, sodium acetate and Sodium acetate is a slow-acting and pathological conditions The use of SODA-BUFER® of 20 a balanced electrolyte complex. It has alkalizing agent that ensures acidosis accompanied with metabolic ml is recomended for correcting antiketogenic, nitrogenpreserving and correction without sharp pH level acidosis. Unlike regular baking soda the pH of acid infusion solutions, lipotropic effects. Xylytol is a pentabasic fluctuations. Due to the balanced (4.2% sodium carbonate) with a pH thus making an angioprotective alcohol with insulinindependent utilization electrolyte complex, the drug ensures of 8.3-11.0, SODA-BUFER®, due to effect as well as minimizing that does not influence the blood glucose correction of electrolyte imbalances. a patented CO2 solution buffering uncomfortable sensations of level and facilitates the secretion of XYLAT® is an effective solution for cases technology, has a pH of 7.3-7.8, which patients during protracted infusion endogenic insulin. Of all of diabetes and ketosis of different is physiological for the human body. therapy. and polyalcohols, xylytol has the most genesis. 9 INFUSION THERAPY

TIVORTIN® GIK®

Indispensible Ready form nitric oxide of polarizing donor solution

How supplied: How supplied: 4.2% L-arginine hydrochloride infusion solution in 100 ml glass bottles. 100 ml and 200 ml glass bottles

The active ingredient of TIVORTIN® • decreases leukocyte activation and GIK® provides the transport of has antiarrhythmic action, lowers is the L-arginine aminoacid, the adhesion to endothelium; glucose in cardiomiocites, stimulates the heightens sensitivity to cardiac only substrate used for nitric oxide • inhibits thrombocyte adhesion, a synthesis of ATP, regulates a glycosides and decreases their (NO) synthesis in the human body. activation and aggregation; transmembrane transport of ions of cardiotoxic effect. + + 2+ TIVORTIN® is a physiological • inhibits adhesion protein synthesis; K , Na , Ca . GIK® is supplied as a final dosage vasodilatator and vascular • prevents pathologic vascular wall GIK® normalizes metabolism of form, therefore eliminating the risk of tone regulator. TIVORTIN® is a remodeling and atherosclerosis myocardium in the conditions of technical error or solution infection. physiological angioprotector: progression. ischemia: provides a heart glucose and reduces oxidization of fat acids,

10 INFUSION THERAPY

GECOTON® GECODEZ®

Saving a life in a Cost-efficient antishock moment therapy

How supplied: How supplied: 200 and 400 glass bottles; 250 and 500 ml polymer containers 200 and 400 ml glass bottles; 500 ml polymer containers

Balanced colloid+hyperosmolar solution 6% HES solution 200/0.5; volemic effect of 85-100%. GECODEZ® is a cost-efficient antishock therapy (the most FAST + STABLE = RELIABLE VOLEMIC EFFECT GECODEZ® is a plasma affordable HES solution in Ukraine) substitute with pronounced volemic effect, high acceptability and additional specific advantages (lowers the «capillary loss» rate).

11 INFUSION THERAPY

AMINOCAPROIC ACID, SORBILACT® 5% solution

Hyperosmolar complex Hemostatic infusion solution preparation

- stimulation of intestinal peristaltics - treatment of intracraneal hypertension

How supplied: How supplied: 200 ml and 400 ml glass bottles 100 ml glass bottles

SORBILACT® – a prophylaxis and treatment of SORBILACT's additional osmodiuretic action AMINOCAPROIC ACID, 5% solution (ACA) enteroplegias are in an early postoperative period. provides maximal effect at therapy of cerebral In addition to the previously-known hemostatic SORBILACT® stimulates intestinal peristaltic edema. The presence of the balanced electrolyte properties, this drug has pronounced antiviral mildly and efficiently; it can be applied starting composition diminishes the losses of electrolytes action. ACA actively combats influenza viruses, from the 1-2nd day after surgery. The intestinal and does not create a "rebound" effect. including such strains as H1N1, H2, H3N2 (human motility stimulation mechanism is based on the SORBILACT® – effective hemodynamic influenza viruses), H5N3, H7N3 (bird influenza direct influence of the drug on the neuroreceptor preparation which quickly removes hypovolemia viruses), parainfluenza and other viruses that apparatus of the intestines, increase of mesenterial and increases SAP and CPP. cause respiratory diseases. The 5% ACA solution circulation and stimulation of villikinine and is administered orally, by inhalation and locally cholecystokinine synthesis. (nasal drops). 12 INFUSION THERAPY

FAMOZOL® SUFER®

Do not suffer, take SUFER®!

How supplied: How supplied: 50 ml glass bottles 5 ml #5 and 10 ml #1 concentrate for preparation of infusion solution in dark glass vials with a solvent in a complete set

FAMOZOL® is a potent competitive III glycoproteins, promotes healing of Iron (III) hydroxide sucrose complex, solution for injection, 20 mg / ml generation inhibitor of H2-receptors. injuries (including stress ulcer scarring) FAMOZOL® strengthens the defense and the cessation of gastrointestinal Shortens hospital stay mechanisms of the gastric mucosa bleeding. Urgently replenishes iron deficiency by increasing the formation of The duration of action is 10 to 12 gastric mucus and its content of hours depending on the dose. Faster clinical recovery Emergency help in anemia Reduces the cost of treatment

13 SIMPLEX INFUSION SOLUTIONS

WATER FOR GLUCOSE 5% POTASSIUM SODIUM CHLORIDE 0,9% solution INJECTIONS solution CHLORIDE

Concentrate for solution for infusion 7,5%

How supplied: How supplied: How supplied: How supplied: 100, 200 and 400 ml glass bottles; 100, 200 and 400 ml glass bottles; 200 ml and 400 ml glass 10 ml and 20 ml vials containers of polymer 100, 200, 250, 500, 1000, 2000, 100, 200, 250, 500, 1000, 2000, bottles 3000, 5000 ml 3000, 5000 ml polymer containers

14 SIMPLEX INFUSION SOLUTIONS

RINGER'S LACTATE SODIUM HYDROCARBONATE RINGER'S SOLUTION SOLUTION 4% solution

How supplied: How supplied: How supplied: 200 ml and 400 ml glass bottles; 200 ml and 400 ml glass bottles; 100 ml and 200 ml glass bottles 250 ml and 500 ml containers containers 100, 200, 500 and 1000 ml

15 SIMPLEX INFUSION SOLUTIONS

MANNIT, POLYGLUCIN solution RHEOPOLYGLUCIN solution 15% solution

How supplied: How supplied: How supplied: 200 ml and 400 ml glass bottles 200 ml and 400 ml glass bottles 200 ml and 400 ml glass bottles

16 ANTISEPTICS AND IRRIGATION SOLUTIONS

DECASAN® CYTOCLIN™

The most effective antiseptic solution

How supplied: Sodium chloride-Cytoclin sol., Glukose-Cytoclin sol., Ringer's-Cytoclin sol., Ringer's 100 ml, 200 ml, 400 ml glass bottles; 1000 ml polymer containers, 2 ml containers lactate-Cytoclin sol., Decasan-Cytoclin sol. How supplied: 1000 ml, 2000 ml, 3000 ml and 5000 ml polymer containers DECASAN® – antiseptic solution and fungal skin diseases, microbial CYTOCLIN™ is a system for irrigation Used as an irrigational liquid for external and endocavitary eczema, pyoinflammatory soft and washing. during endoscopic manipulations, application. 1 ml of solution contains tissue involvement, dental diseases, washing of cavities, and also for 0.2 mg of decametoxyn. One of inflammatory respiratory diseases, CYTOCLIN™ solutions are produced washing of medical equipment. the most important advantages of treatment of wounds, peritoneal in high-volume polymeric containers: DECASAN® is the fact that it affects commissures prevention, efficient 500, 1000, 2000, 3000 and 5000 ml, only bacterial cells, and not the cells of prophylaxis and treatment of wich is an additional factor, providing the human body. Additionally, it has bedsores and trophic ulcers. comfort and safety of use both in anti-inflammatory, desensitizing and DECASAN® is also highly effective in-patient cases and in extreme spasmolitic effect, which makes it a for inhalation treatment. situations. good choice for treatment of bacterial 17 ANTISEPTICS AND IRRIGATION SOLUTIONS

TURUSOL® HOROSTEN®

Protect yourself! Non-hemolizing solution for endoscopy

How supplied: How supplied: 1000 ml, 3000 ml and 5000 ml polymer containers 400 ml polymer bottle, 30 ml and 100 ml spray

1000 ml of solution containes: - 27 g, Turusol is used as irrigation Active component – decametoxyne, a widely known highly effective antiseptic. - 5,4 g in water for injections. solution during realization Auxiliary components: Turusol corresponds to the requirements posed to of endoscopic diagnostic • Glycerin – softens and moisturizes the skin. irrigation solutions: and surgical interferences in urology, ginecology, • Citral – stimulates a tissues reparation and gives a lemon aroma. • does not contain electrolytes; orthopaedia-traumatology • 15% alcohol – does not dry out the skin, but ensures quick drying of the solution. • osomotically adapted; (TURP, hysteroscopy, A wide range of antibacterial, antiviral, antifungal and antiprotozoal effect. • optically translucent; arthroscopy etc.). The absence of an allergenic effect is ensured by the desensitizing effect of • sterile, apyrogenic, constant composition (officinal) decametoxyne. 18 ANTIBACTERIAL AND FUNGICIDAL DRUGS

LEFLOCIN® LEFLOCIN® 750

The gold standard of empiric The shortest antibiotic therapy. path to the The safety standard of goal! fluoroquinolones.

How supplied: How supplied: 500 mg/100 ml glass bottles 750 mg/150 ml glass bottles

III generation of fluoroquinolones Unique mechanism of action provides Short high-dosage treatment by levofloxacyn (750 mg antibacterial drug. the expressed bactericidal effect and once daily, during 5 days) is officially approved for patients The clinical and economic advantages minimum risk of resistance development. aged over 18 with community-acquired pneumonia, acute of levofloxacyn over other groups of Levofloxacin is recognized as one of the bacterial sinusitis, as well as aggravated urinary infections and antibacterial drugs has been scientifically most safe antibacterial medications of acute pyelonephritis. proved in treatment of infections of available today. 750 mg of levofloxacin in one vial ensures the best treatment different etiology and localization. effects in record-breaking time.

19 ANTIBACTERIAL AND FUNGICIDAL DRUGS

BIGAFLON® OFLOXACIN

The proper gatifloxacin

How supplied: How supplied: 400mg/100ml and 800mg/200ml glass bottles 200 mg/100 ml and 400 mg/200 ml glass bottles

BIGAFLON® is a IV generation fluroquinolone. BIGAFLON's effectiveness and safety are tested Quick and reliable antibacterial therapy for a wide Its wide range of effect, including gram- by many years of clinical application and the range of infections. negative, gram-positive, atypical and anaerobic reputation of its manufacturer — YURiA-PHARM, microgerms, ensures highly effective treatment the leader of the Ukrainian market of infusion of virulent diseases regardless of their etiology. drugs.

20 ANTIBACTERIAL AND FUNGICIDAL DRUGS

MAXICIN® LINELID®

Solving the More powerfull! problem of resistant Gram "+" infections!

How supplied: 400 mg/20 ml concentrate for preparation of infusion solution in dark glass How supplied: vials with a solvent in a complete set 300 ml polymer containers

MAXICIN® (moxifloxacin)– is the newest A presence in the complete set of LINELID® - linezolid 2 mg/ml - 600 mg/300 ml fluoroquinolone of IV generation. solvent with the SOLUVEN™ system The first and only oxazolidone approved for clinical use! Combining all positive properties of provides an exceptional quickness, comfort and safety of preparation The main indication - treatment of severe infections caused by previous fluoroquinolones, MAXICIN® anaerobic and aerobic gram-positive microorganisms. possesses the wide spectrum of of solution. bactericidal action, good tolerance, minimum risk of resistance development. The dark glass vials protect preparation from ultraviolet rays influence.

21 ANTIBACTERIAL AND FUNGICIDAL DRUGS

ORNIGIL® CIPROFLOXACIN

Already not a Time-proven metronidazole! effectiveness!

How supplied: How supplied: 500 mg/100 ml and 1000 mg/200 ml glass bottles 200 mg/100 ml glass bottles, 400 mg/200 ml containers

ORNIGIL® (ornidazole) - Most corresponds to the requirements Highly effective antibacterial drug for treatment of infectious - No cross-resistance with metronidazol. posed to preparation for a perioperative diseases of various origin. prophylaxis and treatment of surgical - Side effect occurrence rate does not infections; exceed 3.7%. - Long half-life period provides high - Effectiveness for treatment of effectivenes of therapy in administration trichomoniasis and prostatitis is 98.5%. regimen 1000 mg once daily or 500 mg - Powerfull bactericidal action against twice daily. wide spectrum of anaerobes;

22 ANTIBACTERIAL AND FUNGICIDAL DRUGS

SOLUSEPTOL® METRONIDAZOLE

Co-trimoxazole Anti-anaerobic antiprotozoal syrup - as effective drug for systemic as an intravenous administration drug!

How supplied: How supplied: syrup, 4 ml contains: 100 mg of sulpamethoxazole and 20 mg of trimethoprim; in 100, 200 ml bottles 500 mg/100 ml glass bottles

SOLUSEPTOL® ensures consistent peak plasma concentration levels that Effective drug for the treatment: approximate those achieved by the intravenous solution, and has an elimination - abdominal infections (peritonitis, abdominal and liver abscesses) half-life of a tablet drug. - pelvic infections (endometritis, ovarian and fallopian tubes abscesses, Co-trimoxazole is the drug of choice for treatment and prevention of urinary postoperative complications) infections, HIV/AIDS-associated infections (pneumocystic pneumonia, toxoplasmosis) and infectious diarrheas. Co-trimoxazole is included into the - infections of the lower respiratory tract (pneumonia, empyema, lung abscesses) British National Formulary and the WHO Formulary. - infections of the skin, bones, sepsis, endocarditis SOLUSEPTOL® is a highly effective and pharmacoeconomically favorable - infections of the central nervous system (meningitis, brain abscess) alternative to linezolid, clindamycin and vancomycin for treatment of infections Prevention of infectious complications caused by anaerobic caused by methicillin-resistant Staphilococcus aureus (MRSA). microbes during surgery operations! 23 ANTIBACTERIAL AND FUNGICIDAL DRUGS

FLUCONAZOLE FLUCONAZOLE 400 mg

A unique decision of The most effective the problem antifungal drug of fungal infections

How supplied: How supplied: 100 mg/50 ml and 200 mg/100 ml glass bottles 400 mg/200 ml glass bottles

Fluconazole is the drug of choice Intravenous administration Most effective in case of: • generalized fungal infections in for fungal infections of various of fluconazole ensures high • severe hospital fungal infections; oncologic patients concurrent with localization caused by Candida effectiveness against fungal chemo- and roetgen therapy. fungi, including candidemia. infections of various localization, • fungal infections in intensive care unit patients; • fungal infections caused by minimal treatment duration for resistant fungi. The prolonged elimination half-life acute uncomplicated disease forms, • systemic candidosis (including of the drug – 30 hours – allows to and a high anti-relapse effect. fungemia); administer it only once daily. • opportunistic fungal infections in patients with HIV/AIDS;

24 DRUGS MODIFYING A CARTILAGE

HYALUAL®-ARTRO

Move without pain! A unique decision for patients with osteoarthritis

How supplied: 1.1% and 1.8% in pre-filled 1 ml and 2 ml syringes, with additionally supplied needles for intraarticular injection

HYALUAL®-ARTRO is a preparation The first component of a preparation The second component of a preparation - Sodium All these effects of sodium for intraarticular injection, which - Hyaluronic acid has an anaesthetic succinate has a pathogenetic effects. It normalizes succinate allow to increase life- has the opportunity to influence and antiinflammatory actions and the intracellular metabolism of the hondrocytes, span of cartilage tissue and actively on pathogenetic mechanisms of improves the functional state of joints stimulates a syntesis of intracellular matrix of a fights for the postponement of progressing of osteoarthritis. and quality of life of patient. cartilage, has an antioxidative action. endoprotesis setting.

Osteoarthritis stage I II III The treatment course requires 64 mg sodium succinate 64-96 mg sodium succinate 96 mg sodium succinate Mode 32 mg sodium succinate at the interval of 30 days The treatment course 1-2 times per year *Hyalual® ARTRO 1.8% - 2 ml contains 32 mg of sodium succinate and 36 mg of hyaluronic acid

25 ORAL SOLUTIONS

LACTUVIT®

A natural laxative that normalizes the intestinal function

LACTUVIT® is a physiological and safe In case of hepatic encephalopathia regulator of a bowel motor function. LACTUVIT® decreases concentration It ensures bowel evacuation and of ammonia in the blood due to softens a bowels content. It results diminishing of its receipt from to the correction of chronic lock bowels. Lactuvite decreases bowels practically of any its form. Thus does pH, hinders to reproduction of not render meaningful side effects bacteria and suction of ammonia and does not cause getting used. and other toxins. The acting mechanism of LACTUVIT® is similar to that of food fiber. It creates an ideal nutritive medium for beneficial bifidus bacteria and lactic acid bacilli. It assists renewal of normal balance of microflora.

How supplied: 100 ml and 200 ml bottles

26 ORAL SOLUTIONS

TIVORTIN® ASPARTATE

Indispensible nitric oxide donor

The active ingredient of TIVORTIN® atherosclerosis occurrence and ASPARTATE is the L-arginine aminoacid, progression. The pharmaceutical the only substrate used for nitrogen form – oral solution – ensures oxide (NO) synthesis in the human dosage accuracy and convenient body. administration. TIVORTIN® ASPARTATE TIVORTIN® is a physiological can be used for patients with vasodilatator, a vascular tone regulator concurrent diabetes mellitus. in normal conditions and as response TIVORTIN® ASPARTATE oral solution to various stimuli. is part of a switch therapy with NO TIVORTIN® is a physiological donors and ensures: angioprotector: • maintained high clinic effectiveness • decreases leukocyte activation and of the therapy; adhesion to endothelium; • shorter in-patient treatment time; •i nhibits thrombocyte aggregation • possibility to continue treatment at and parietal thrombosis; home. • inhibits vessel smooth muscle proliferation and pathologic vascular wall remodeling. All of the above contributes to normalization of the endothelium How supplied: function and prevention of oral solution in 100 ml and 200 ml bottles

27 ANTI-TUBERCULOSIS DRUGS

ISONIAZID syrup RIFONAT®

Protect your The most effective child from pharmaceutical form tuberculosis! of the most effective drug!

How supplied: How supplied: 100 ml and 200 ml bottles Infusion solution concentrate 30 mg/ml. 5, 15 and 20 ml vials (150, 450 and 600 mg of Rifamycin accordingly). 15 ml and 20 ml vials (450 and 600 mg of Rifamycin accordingly) complete with a solvent The pharmaceutical form – a syrup – The accurate dosing of syrup is used for the most effective ensures treatment and prophylaxis Intravenous form of Rifamycin. In this way the highest efficiency and safe treatment and chemical effectiveness and prevents side First-line antituberculosis drug. of treatment is ensured along prophylaxis of tuberculosis for effects. Intravenous administration with minimizing the risk of diseased and infected children with 1 ml of Isoniazid syrup contains 20 of RIFONAT® provides 100% development of MTB resistance. BCG vaccination complications, as mg of isoniazid. bioavailability and creates Inhalation application is possible. well as for those who had come in maximum concentrations of contact with tuberculosis patients. preparation in blood and tissues.

28 ANTI-TUBERCULOSIS DRUGS

INBUTOL® PASKONAT® BITUB®

Unique combination of safety and efficiency!

Control and Time-tested effectiveness! tuberculosis treatment

How supplied: How supplied: How supplied: 10% solution in 10 ml and 20 ml vials 12 g/400 ml glass bottles 5 ml ampoules #10, 5 ml vials #5

Intravenous form of Ethambutol. First-line PASKONAT® is used mainly for treatment of BITUB® – 10 % solution of isoniazid for injection. antituberculosis drug. Resistance of bacillus tuberculosis form that had not responded to After intravenous administration, the plasma and Kochii to INBUTOL® develops slowly. The use of earlier therapy, recurrent diseases, forms resistant tissue concentrations of isoniazid is several times INBUTOL® (bioavailability of 100%) instead of a to the main antituberculosis drugs, and in cases higher than those after oral intake. tablet form of ethambutol (bioavailability of 77%) of patient intolerance to drugs. Using PASKONAT® Essential drug for patients with severe and during inpatient treatment allows to decrease in comprehensive tuberculosis treatment allows complicated forms of tuberculosis, and tuberculosis the administered dose while maintaining enhancing the effect of other antituberculosis with GI tract comorbidity. high treatment effectiveness. Decreasing the drugs and slow down the development of the The drug can be inhaled via nebulizer. ethambutol dosage lowers the risk of tuberculosis bacillus Kochii resistance to the drugs. The preparation includes the methionine, polychemotherapy side effects. which prevents the development of hepatotoxic side effects.

29 ANALGESICS AND ANAESTHETICS

LONGOCAIN® and LONGOCAIN® HEAVY NOVOCAIN 0,25% and 0,5% solution

How supplied: How supplied: 200 ml glass bottles, 5 ml ampoules #10 and 5 ml vials #5 200 ml and 400 ml glass bottles

LONGOKAIN® - bupivacaine 2.5 mg/ml Indications for use: Powerful long-acting anesthetic for spinal anesthesia in surgery, trauma and obstetrics. - for local anesthesia (infiltration , conduction , epidural) in Anesthesia occurs rapidly (within 5-10 minutes) and lasts for 6-8 hours. various surgical procedures; It is indicated for spinal anesthesia for urologic surgery, surgery of the lower limbs up to 2-3 hours, - for novocaine blockade; and in abdominal surgery for up to 45-60 minutes. - for circulatory and paravertebral blockade; LONGOKAIN® HEAVY - bupivacaine 5 mg/ml - is designed for hyperbaric spinal anesthesia, in - for the relief of pain in gastric ulcer , duodenal ulcer, etc.; which the gravity of the solution and the position of the patient on the table significantly affect - to relieve spasms of peripheral blood vessels and improve the initial distribution LONGOKAIN® HEAVY in the subarachnoid space. When using LONGOKAIN® microcirculation in frostbite; HEAVY level of sensory-motor unit more manageable than using isobaric solutions. Approved for - to potentiate the action of general anesthesia. use in children. 30 ANALGESICS AND ANAESTHETICS

INFULGAN®

The most widely prescribed analgesic in Europe: prescribed in 78% of postoperative patients

• Potent analgesic for intravenous infusions in a ready- to-use form; • Safe alternative to existing antipyretics (especially in paediatrics); • Absolutely safe, even when NSAIDs are contraindicated or should be used with caution; • No influence on aggregation and blood clotting time; • The smallest number of drug interactions; • A basic component of multimodality anaesthesia

How Supplied: Paracetamol, solution for infusions 1000 mg – 100 mL Paracetamol, solution for infusions 200 mg – 20 mL

31 CLINICAL NUTRITION

AMINOL® GLUXYL®

The basis of effective parenteral nutrition: optimal source of carbohydrates necessary for amino-acids assimilation

How supplied: How supplied: 100, 200 and 400 ml glass bottles 200 ml and 400 ml glass bottles

GLUXYL® is a pyruvate and glucose levels. One A balanced complex of L-forms of dispensable and indispensable component of parenteral feeding. of the obligatory conditions for aminoacids for parenteral nutrition. Contains xylytol, glucose, sodium effective parenteral nutrition is the acetate and a balanced complex concurrent administration of plastic of electrolytes. Quickly absorbed in material donors (amino-acids) and patients with normal metabolism energy donors (GLUXYL®). and under stress (xylytol enhances glucose utilization) and does not increase the lactate,

32 ANTIVIRAL DRUGS

AKK®

A reliable barrier against flu and cold!

АKK® has an evident antiviral action, For the purpose of flu and ARVI prevents contamination and blocks profilaction AKK should be use virus propagation. АKK® hampers intranasal pour 2-3 drops 4-5 times penetration of flu A and B viruses, a day; For purpose of treatment – herpes, RS-virus, adenovirus and every 3 hours. arbovirus in human cells. Course of treatment lasts 3-7 days. AKK® improves the cellular and humoral indexes of specific and The drug is suitable for newborns. nonspecific defence of organism in case of ARVI. AKK® strengthens an immune answer during immunization by influenzal vaccines.

How supplied: 10 disposable containers of 2 and 5 ml

33 DIALYSIS SOLUTIONS

DIAVITEC® PD

DIAVITEC® PD 1,5 % / DIAVITEC® PD 2,5 % / DIAVITEC® PD 4,25 % 1 liter of solution DIAVITEC® PD 1.5% containing: sodium chloride solution 5.669 g; sodium lactate 3,922 g; hexahydrate 0.383 g; hexahydrate 0.102 g; glucose monohydrate 15 g - 1.5% (equivalent to 13.6 g anhydrous glucose - 1.36% ); 1 liter of solution DIAVITEC® PD 2.5% containing: sodium chloride solution 5.669 g; sodium lactate 3,922 g; calcium chloride hexahydrate 0.383 g; magnesium chloride hexahydrate 0.102 g; glucose monohydrate 25 g - 2.5% (equivalent to 22.7 g anhydrous glucose - 2.27 %); 1 liter of solution DIAVITEC® PD 4.25% containing: sodium chloride solution 5.669 g; sodium lactate 3,922 g; calcium chloride hexahydrate 0.383 g; magnesium chloride hexahydrate 0.102 g; glucose monohydrate 42.5 g - 4.25% (equivalent to 38.6 g anhydrous glucose - 3.86 %); Excipients: Water for injections

Indications. - Acute renal failure; - Chronic renal failure; - Severe water retention in the body; How supplied: - Electrolyte imbalance; 2 000 ml polymer containers - Intoxication by drugs if another treatment is ineffective.

34 ACCESSORIES FOR INFUSION THERAPY

SOLUVEN™

Sodium chloride-Soluven sol., Glukose-Soluven sol., Ringer's-Soluven sol., Ringer's lactate-Soluven sol. How supplied: 50 ml, 100 ml, 200 ml and 400 ml polymer containers

SOLUVEN™ is a closed system for SOLUVEN™ system eliminates SOLUVEN™ systems made from drugs reconstitution. possibility of hit of medical polymeric materials, that is the preparation in an external additional factor of providing of The feature of the system is environment, contact of personnel safety of the use both in hospital emergency safety, comfort, or patient with it. conditions and in extreme situations simplicity and quickness of process on the outpatient stage of medicare. of infusion solutions preparing.

35 ACCESSORIES FOR INFUSION THERAPY

SYRINGES WITH TWO NEEDLES I.V. SETS

Unique high quality patented 3-component syringes with two needles

Yuria-Pharm 3-component syringes are supplied with 2 needles of different size: • the larger needle is attached to the syringe and is recommended for the intake of the medication solution from the container; • the smaller needle, supplied with the syringe, is recommended for the injection. Using the Yuria-Pharm syringes supplied with two different-sized needles ensures: 1. Infusion systems are used for administration of solutions; • maintaining sterility during injection; • the option to perform the injection 2. Transfusion systems are used for blood and • the option to choose the suitable with a sharp needle, and not the one blood component transfusions. needle diameter; that was used for the intake of the • the option to use a smaller diameter medication solution; needle for injections for children; • cost saving when purchasing a • the option to use the larger diameter syringe with two needles compared needle for easier intake of the to a separate purchase of a one- medication solution; needle syringe and an extra needle.

36 «ULAIZER» COMPRESSOR NEBULIZERS

Ulaizer® Pro Ulaizer® Home Ulaizer® First Aid

Ulaizer® Pro is a compressor nebulizer for Ulaizer® Home is a home-use compressor Ulaizer® First Aid is an ultra compact professional applications nebulizer for the entire family compressor nebulizer

Key Features: Key Features: Key Features: • Conforms to the European standards of • Compact handheld nebulizer • Ultra compact size nebulizer therapy • Comfortable use by all family members • Conforms to the European standards of • Universal application in all age groups • Contemporary design nebulizer therapy • Minimal losses of active medication • Wide selection of accessories • Minimal losses of active medication • Washable frame • Low noise levels • Wide selection of accessories • Protection from overheating • Protection from overheating • Convenient carrying handle • Adjustable air supply rate • Minimal losses of active medication • Low noise levels • Supplied with 5 replaceable air filters

37 MEDICATIONS FOR NEBULIZER THERAPY

DECASAN® SODIUM CHLORIDE NEBUTAMOL® Nebufluzon®

First of a kind Universal solvent Bronchodilatory drug Included to the list inhalable antiseptic for inhalational from the group of of vital and essential medications selective adrenergic drugs! agonists

How Supplied: How Supplied: How Supplied: How Supplied: Single-use containers 2 mL each, Single-use containers 2 mL each, Single-use containers 2 mL each, Single-use containers 2 mL each, 10 pcs per package 10 pcs per package 10 pcs per package 10 pcs per package

DECASAN® contains 0.02% solution SODIUM CHLORIDE contains 0.9% NEBUTAMOL® 2 mg solution of NEBUFLUZON® - fluticasone propionate. of decametoxine for inhalations. solution of sodium chloride for salbutamol for inhalations. Single-dose containers of 2 ml each, The medication possesses a potent inhalations and instillations into nasal Short action β agonist. 10 pcs per package. 1 ml suspension antibacterial, antiviral and fungicidal cavity. 2 contains 1 mg of fluticasone It is used for emergency treatment of action. Additionally, it exerts 0.9% solution of sodium chloride propionate. antispasmodic, anti-inflammatory and exacerbations in patients with asthma (normal ) is the sole universal and COPD. NEBUFLUZON® is the newest inhalable desensitizing influence. physiological solvent for inhalational glucocorticoid. The medication potentiates the action medications. A single dose for cessation of an exacerbation - 1 single-dose container NEBUFLUZON® is included to the list of of other antibacterial agents. No toxic The solution does not cause irritation of vital and essential drugs. influence upon human organism is of Nebutamol. The attack of asthma respiratory mucosa; it has no significant It is widely used for the treatment of found. and COPD is ceased with the first drug interactions and is compatible minute of inhalation. asthma and COPD. with all agents used for in inhalational therapy.

38 DRUGS FOR TREATMENT OF WOUNDS AND ULCERS

LACERTA®

Unique COMBINATION for REGENERATION!

Hyaluronate activates regeneration by increasing migration and proliferation of fibroblasts; hyaluronate with succinate (LACERTA®) accelerates this process by activating the metabolic processes within cells involved in tissue regeneration, including proliferation of fibroblasts. Lacerta is used in the treatment of venous ulcers, pressure ulcers, fistulas, burns, long-existing defects in the covering tissue and to the acceleration of normal wound healing.

How supplied: : 1.5% in pre-filled 1 ml and 2 ml syringes, 0,144% in the form of a spray in cylinder 50 and 150 ml

39 YURiA-PHARM LTD 10, Amosova street, Kyiv, Ukraine, 03680 tel/fax: +38 (044) 246-8191, 246-8383 www.uf.ua/int

Leader of intravenous drugs market in Ukraine and CIS ISO 9001: 2009