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Home , Acitretin, Adapalene, Alglucosidase alfa, Alteplase, Aminosalicylate, Ammonium ferric citrate

Estonian Statistics on Medicines 2016

ATC code ATC / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

A ALIMENTARY TRACT AND 167,8985 A01 STOMATOLOGICAL PREPARATIONS 0,0738 A01A STOMATOLOGICAL PREPARATIONS 0,0738 A01AB Antiinfectives and for local oral treatment 0,0738 A01AB09 (O) 7088 g 0,2 g 0,0738 A01AB12 (O) 1951200 ml A01AB81 + (dental) 30200 pieces A01AB82 + (dental) 680 g A01AC for local oral treatment A01AC81 + Thymol (dental) 3094 ml A01AD Other agents for local oral treatment A01AD80 + Cetylpyridinium (gingival) 227150 g A01AD81 Lidocaine+ (O) 30900 g A01AD82 salicylate (O) 864720 pieces A01AD83 Lidocaine+ Chamomille extract (O) 370080 g A01AD90 Lidocaine+ Paraformaldehyde (dental) 405 g A02 FOR ACID RELATED DISORDERS 47,1312 A02A 1,0133 Combinations and complexes of , and A02AD 1,0133 compounds A02AD81 Aluminium hydroxide+ (O) 811120 pieces 10 pieces 0,1689 A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 3101974 ml 50 ml 0,1292 A02AD83 + Magnesium carbonate (O) 3434232 pieces 10 pieces 0,7152 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 46,1179 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 2,3855 A02BA02 Ranitidine (O) 340327,5 g 0,3 g 2,3624 A02BA02 Ranitidine (P) 3318,25 g 0,3 g 0,0230 A02BC Proton pump inhibitors 43,7324 A02BC01 (O) 263238,18 g 0,02 g 27,4097 A02BC02 (O) 172288,06 g 0,04 g 8,9697 A02BC02 Pantoprazole (P) 356,4 g 0,04 g 0,0186 A02BC03 (O) 9,87 g 0,03 g 0,0007 A02BC05 (O) 102877,88 g 0,03 g 7,1414 A02BC05 Esomeprazole (P) 2770 g 0,03 g 0,1923 A02BD Combinations for eradication of Helicobacter pylori <0,0001 A02BD08 Bismuth subcitrate+ Tetracycline+ (O) 240 pieces 12 pieces <0,0001 DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03 7,9186 DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03A 6,9014 DISORDERS A03AA Synthetic , with tertiary amino group 0,9452 A03AA04 (O) 136170 g 0,3 g 0,9452 A03AB Synthetic anticholinergics, quaternary compounds <0,0001 A03AB02 Glycopyrronium bromide (P) 0,02 g 3 mg <0,0001 A03AD Papaverine and derivatives 4,4043 A03AD01 hydrochloride (P) 65,8 g 0,1 g 0,0014 A03AD02 (O) 206916,32 g 0,1 g 4,3090 A03AD02 Drotaverine (P) 4507 g 0,1 g 0,0939 A03AX Other drugs for functional gastrointestinal disorders 1,5519 A03AX13 (O) 372600,6965 g 0,5 g 1,5519 A03B BELLADONNA AND DERIVATIVES, PLAIN 0,1142 A03BA Belladonna alkaloids, tertiary 0,0971 A03BA01 (O, P) 25,39 g 0,0015 g 0,0352 A03BA01 Atropine (P) 44,53 g 0,0015 g 0,0618

1/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

Belladonna alkaloids, semisynthetic, quaternary ammonium A03BB 0,0171 compounds A03BB01 Butylscopolamine (O) 58,4 g 0,06 g 0,0020 A03BB01 Butylscopolamine (P) 430,5 g 0,06 g 0,0149 A03BB01 Butylscopolamine (R) 4,8 g 0,06 g 0,0002 A03F PROPULSIVES 0,9030 A03FA Propulsives 0,9030 A03FA01 (O) 10519 g 0,03 g 0,7302 A03FA01 Metoclopramide (P) 1899,3 g 0,03 g 0,1318 A03FA01 Metoclopramide (R) 0,5 g 0,03 g <0,0001 A03FA03 Domperidone (O) 589,8 g 0,03 g 0,0409 A04 AND ANTINAUSEANTS 0,1264 A04A ANTIEMETICS AND ANTINAUSEANTS 0,1264 A04AA (5-HT3) antagonists 0,1117 A04AA01 Ondansetron (P) 29,62 g 0,016 g 0,0039 A04AA02 Granisetron (O) 60,64 g 0,002 g 0,0631 A04AA02 Granisetron (P) 64,4 g 0,003 g 0,0447 A04AD Other antiemetics 0,0147 A04AD01 (TD) 15 pieces 1 pieces <0,0001 A04AD12 Aprepitant (O) 395,865 g 0,095 g 0,0087 A04AD81 Fosaprepitant (P) 274,65 g 0,095 g 0,0060 A05 AND 2,4278 A05A BILE THERAPY 0,4881 A05AA Bile acid preparations 0,4881 A05AA02 Ursodeoxycholic acid (O) 175775 g 0,75 g 0,4881 A05B LIVER THERAPY, LIPOTROPICS 1,9397 A05BA Liver therapy 1,9397 A05BA03 Silymarin (O) 2963650 pieces A05BA80 Essential phospholipids (O) 2794350 pieces 3 pieces 1,9397 A05BA80 Essential phospholipids (P) 1865 pieces A06 DRUGS FOR CONSTIPATION 15,1259 A06A DRUGS FOR CONSTIPATION 15,1259 A06AB Contact 7,1290 A06AB02 Bisacodyl (O) 14645 g 0,01 g 3,0498 A06AB02 Bisacodyl (R) 875,6 g 0,01 g 0,1823 A06AB06 Senna glycosides (O) 10300 pieces 1 pieces 0,0214 A06AB08 picosulfate (O) 9304,062 g 0,005 g 3,8751 A06AB80 Sodium picosulfate+ + (O) 186 pieces 2 pieces 0,0002 A06AD Osmotically acting laxatives 7,1545 A06AD11 Lactulose (O) 21946884,8 g 6,7 g 6,8216 A06AD15 Macrogol (O) 1598600 g 10 g 0,3329 Macrogol+ Sodium citrate+ Citric acid+ + A06AD80 35000 ml chloride (O) Sodium sulphate, anhydrous+ + Sodium A06AD81 53092 pieces chloride+ Macrogol+ Sodium carbonate (O)

Macrogol+ Sodium sulphate, anhydrous+ Sodium chloride+ A06AD83 1 pieces Potassium chloride+ Ascorbic acid+ Sodium ascorbate (O) Sodium sulphate, anhydrous+ magnesium A06AD85 1102112 ml heptahydrate+ Potassium sulphate (O) A06AG 0,8425 A06AG11 Laurilsulfate, incl. combinations+ + Sodium citrate (R) 404564 pieces 1 pieces 0,8425 A06AH Peripheral receptor antagonists A06AH03 Naloxegol (O) 8,25 g A06AX Other drugs for constipation A06AX01 (R) 300 pieces

2/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

Sodium hydrogen carbonate+ Sodium dihydrogen A06AX80 100 pieces (R) ANTIDIARRHEALS, INTESTINAL A07 3,8855 ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A07A INTESTINAL ANTIINFECTIVES <0,0001 A07AA Antibiotics <0,0001 A07AA11 Rifaximin (O) 7,2 g 0,6 g <0,0001 A07B INTESTINAL ADSORBENTS 0,4636 A07BC Other intestinal adsorbents 0,4636 A07BC05 Diosmectidum (O) 2003400 g 9 g 0,4636 A07C WITH A07CA Oral rehydration formulations Sodium chloride+ Potassium chloride+ Sodium citrate+ A07CA80 60780 pieces (O) A07D 0,9245 A07DA Antipropulsives 0,9245 A07DA03 (O) 4439,5 g 0,01 g 0,9245 A07E INTESTINAL ANTIINFLAMMATORY AGENTS 1,9117 A07EA Corticosteroids acting locally 0,0003 A07EA06 (O) 1,2 g 0,009 g 0,0003 A07EA06 Budesonide (R) 1,6177 g A07EC Aminosalicylic acid and similar agents 1,9114 A07EC01 (O) 783050 g 2 g 0,8154 A07EC02 (O) 722900 g 1,5 g 1,0036 A07EC02 Mesalazine (R) 66584 g 1,5 g 0,0924 A07F ANTIDIARRHEAL 0,5857 A07FA Antidiarrheal microorganisms 0,5857 A07FA02 Saccharomyces boulardii (O) 281237,5 g 1 g 0,5857 A07X OTHER ANTIDIARRHEALS A07XA Other antidiarrheals A07XA04 (O) 2681,92 g A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0171 A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0171 A08AB Peripherally acting antiobesity products 0,0171 A08AB01 Orlistat (O) 2958,48 g 0,36 g 0,0171 A09 DIGESTIVES, INCL. 1,4609 A09A DIGESTIVES, INCL. ENZYMES 1,4609 A09AA preparations 1,4603 A09AA02 Lipase+ Amylase+ Protease (O) 2804925 pieces 4 pieces 1,4603 A09AC Enzyme and acid preparations, combinations 0,0006 A09AC80 Pepsin+ Betaine (O) 800 pieces 3 pieces 0,0006 A10 DRUGS USED IN DIABETES 61,5309 A10A AND ANALOGUES 16,5197 A10AB Insulins and analogues for , fast-acting 6,2793 A10AB01 (human) (P) 900000 U 40 U 0,0469 A10AB04 Insulin lispro (P) 24964500 U 40 U 1,2997 A10AB05 Insulin aspart (P) 81061500 U 40 U 4,2203 A10AB06 Insulin glulisine (P) 13684500 U 40 U 0,7124 A10AC Insulins and analogues for injection, intermediate-acting 0,1243 A10AC01 Insulin (human) (P) 2388000 U 40 U 0,1243 Insulins and analogues for injection, intermediate- or long- A10AD 1,4836 acting combined with fast-acting A10AD04 Insulin lispro (P) 10512000 U 40 U 0,5473 A10AD05 Insulin aspart (P) 17985000 U 40 U 0,9363 A10AE Insulins and analogues for injection, long-acting 8,6325 A10AE04 Insulin glargine (P) 94092000 U 40 U 4,8987

3/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

A10AE05 Insulin detemir (P) 71718000 U 40 U 3,7338 A10B GLUCOSE LOWERING DRUGS, EXCL. INSULINS 45,0111 A10BA 19,7828 A10BA02 (O) 18999126 g 2 g 19,7828 A10BB Sulfonylureas 15,4082 A10BB07 (O) 1414,95 g 0,01 g 0,2947 A10BB09 (O) 248991 g 0,06 g 8,6421 A10BB12 (O) 6215,1 g 0,002 g 6,4715 A10BD Combinations of oral blood glucose lowering drugs 4,2250 A10BD07 Metformin+ Sitagliptin (O) 1863400 pieces 2 pieces 1,9403 A10BD08 Metformin+ Vildagliptin (O) 803160 pieces 2 pieces 0,8363 A10BD10 Metformin+ Saxagliptin (O) 308580 pieces 2 pieces 0,3213 A10BD11 Metformin+ Linagliptin (O) 659940 pieces 2 pieces 0,6872 A10BD15 Metformin+ Dapagliflozin (O) 150528 pieces 2 pieces 0,1567 A10BD20 Metformin+ Empagliflozin (O) 272040 pieces 2 pieces 0,2833 A10BF Alpha glucosidase inhibitors 0,0001 A10BF01 Acarbose (O) 21 g 0,3 g 0,0001 A10BG Thiazolidinediones 0,0883 A10BG03 Pioglitazone (O) 1271,34 g 0,03 g 0,0883 A10BH Dipeptyl peptidase 4 (DPP-4) inhibitors 3,2135 A10BH01 Sitagliptin (O) 72375,1 g 0,1 g 1,5072 A10BH02 Vildagliptin (O) 7788 g 0,1 g 0,1622 A10BH03 Saxagliptin (O) 522,9 g 5 mg 0,2178 A10BH04 Alogliptin (O) 32,2 g 25 mg 0,0027 A10BH05 Linagliptin (O) 3178,05 g 5 mg 1,3237 A10BX Other blood glucose lowering drugs, excl. insulins 2,2931 A10BX04 Exenatide (P) 10,9902 g 0,286 mg 0,0800 A10BX07 Liraglutide (P) 689,076 g 1,2 mg 1,1958 A10BX09 Dapagliflozin (O) 2160,6 g 10 mg 0,4499 A10BX10 Lixisenatide (P) 1,473 g 20 mcg 0,1534 A10BX12 empagliflozin (O) 3478,65 g 17,5 mg 0,4140 A11 16,7523 A11A , COMBINATIONS 2,0634 A11AA Multivitamins with minerals 2,0634 A11AA03 Multivitamins+ elements (O) 990840 pieces 1 pieces 2,0634 A11C A AND D, INCL. COMBINATIONS OF THE TWO 1,1212 A11CC and analogues 1,1212 A11CC01 (O) 148870400 U 400 U 0,7751 A11CC03 (O) 0,0003 g 0,001 mg 0,0006 A11CC04 (O) 0,0864 g 0,001 mg 0,1800 A11CC05 Colecalciferol (O) 31800000 U 400 U 0,1656 VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN A11D 2,2175 B6 AND B12 A11DA Vitamin B1, plain 0,2748 A11DA01 (P) 6599 g 0,05 g 0,2748 A11DA03 (O) 2016510 pieces A11DB Vitamin B1 in combination with and/or 1,9427 A11DB80 Thiamine+ (P) 4355 pieces 1 pieces 0,0091 A11DB81 Benfotiamine+ Pyridoxine (O) 192060 pieces 3 pieces 0,1333 A11DB84 Thiamine+ Pyridoxine+ (O) 758360 pieces 1 pieces 1,5793 A11DB85 Thiamine+ Pyridoxine+ Cyanocobalamin+ Lidocaine (P) 106115 pieces 1 pieces 0,2210 A11E VITAMIN B-COMPLEX, INCL. COMBINATIONS 0,7689 A11EA Vitamin B-complex, plain 0,7689 Thiamine+ + + Calcium pantothenate+ A11EA80 369200 pieces 1 pieces 0,7689 Pyridoxine (O)

4/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

A11G ASCORBIC ACID (), INCL. COMBINATIONS 3,2377 A11GA Ascorbic acid (vitamin C), plain 3,2377 A11GA01 Ascorbic acid (O) 303420 g 0,2 g 3,1594 A11GA01 Ascorbic acid (P) 7525 g 0,2 g 0,0784 A11H OTHER PLAIN VITAMIN PREPARATIONS 0,0374 A11HA Other plain vitamin preparations 0,0374 A11HA02 Pyridoxine (O) 190 g 0,16 g 0,0025 A11HA02 Pyridoxine (P) 2342,5 g 0,16 g 0,0305 A11HA03 (O) 80 g 0,2 g 0,0008 A11HA05 (O) 2 g A11HA08 (O) 345 g 0,2 g 0,0036 A11J OTHER VITAMIN PRODUCTS, COMBINATIONS 7,3062 A11JA Combinations of vitamins A11JA80 Combinations of vitamins (O) 1200 ml A11JB Vitamins with minerals 7,3062 A11JB81 Pyridoxine+ Magnesium (O) 11162900 pieces 4 pieces 5,8117 Thiamine+ Riboflavin+ Pyridoxine+ Cyanocobalamin+ A11JB82 Ascorbic acid+ Biotin+ Nicotinamide+ Calcium pantothenate+ 717645 pieces 1 pieces 1,4945 Calcium+ Magnesium+ Folic acid+ (O) A12 MINERAL SUPPLEMENTS 10,3734 A12A CALCIUM 6,5763 A12AA Calcium 0,6668 A12AA03 (P) 18410 g 3 g 0,0128 A12AA04 Calcium carbonate (O) 942125 g 3 g 0,6540 A12AX Calcium, combinations with vitamin D and/or other drugs 5,9096 A12AX80 Calcium+ Colecalciferol (O) 996450 pieces 1 pieces 2,0751 A12AX80 Calcium+ Colecalciferol (O) 3682560 pieces 2 pieces 3,8345 A12B POTASSIUM 0,1885 A12BA Potassium 0,1885 A12BA01 Potassium chloride (O) 271560 g 3 g 0,1885 A12BA80 Potassium chloride+ Potassium hydrogen carbonate (O) 4000 pieces A12C OTHER MINERAL SUPPLEMENTS 3,6086 A12CC Magnesium 0,5090 A12CC04 (O) 488829,6 g 2 g 0,5090 A12CX Other mineral products 3,0996 A12CX80 + Potassium aspartate (O) 4396900 pieces 3 pieces 3,0522 A12CX80 Magnesium aspartate+ Potassium aspartate (P) 22770 pieces 1 pieces 0,0474 A12CX83 Phosphate (O) 7500 pieces A14 ANABOLIC AGENTS FOR SYSTEMIC USE 0,0020 A14A ANABOLIC STEROIDS 0,0020 A14AB Estren derivatives 0,0020 A14AB01 (P) 1,9 g 0,002 g 0,0020 A14B OTHER ANABOLIC AGENTS A14BX Other anabolic agents A14BX80 Riboxine (O) 80 g OTHER ALIMENTARY TRACT AND METABOLISM A16 1,0727 PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM A16A 1,0727 PRODUCTS A16AA Amino acids and derivatives 0,0036 A16AA01 Levocarnitine (O) 3400 g 2 g 0,0035 A16AA02 Ademetionine (O) 30 g A16AA05 (O) 1 g 0,2 g <0,0001 A16AA80 L-arginiin (O) 3000 g A16AA81 (O) 1140 g

5/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

A16AB Enzymes 0,0059 A16AB02 (P) 166000 U 300 U 0,0012 A16AB03 Agalsidase alfa (P) 1,26 g 0,001 g 0,0026 A16AB04 Agalsidase beta (P) 1,46 g 0,005 g 0,0006 A16AB07 (P) 52,85 g 0,1 g 0,0011 A16AB09 (P) 1,344 g A16AB10 (P) 60000 U 300 U 0,0004 A16AX Various alimentary tract and metabolism products 1,0632 A16AX01 Thioctic acid (O) 100890 g 0,2 g 1,0505 A16AX01 Thioctic acid (P) 510 g 0,2 g 0,0053 A16AX03 (O) 2000 g 20 g 0,0002 A16AX05 dihydrate (O) 518,75 g 0,15 g 0,0072 A16AX07 Sapropterin (O) 180 g A16AX80 Creatine (O) 4200 g B BLOOD AND BLOOD FORMING ORGANS 105,5490 B01 AGENTS 85,3423 B01A ANTITHROMBOTIC AGENTS 85,3423 B01AA antagonists 7,0482 B01AA03 (O) 25383,7 g 0,0075 g 7,0482 B01AB group 2,9139 B01AB01 Heparin sodium (P) 496875000 U 10000 U 0,1035 B01AB02 III (P) 2500 U 2100 U <0,0001 B01AB04 Dalteparin sodium (P) 110025000 U 2500 U 0,0917 B01AB05 (P) 2130280000 U 2000 U 2,2182 B01AB06 (P) 30390500 U 2850 U 0,0222 B01AB12 (P) 574350000 U 2500 U 0,4784 B01AC aggregation inhibitors, excl. heparin 67,4992 B01AC04 (O) 161411,4 g 0,075 g 4,4819 B01AC06 Acetylsalicylic acid (O) 6515334 pieces 1 pieces 13,5682 B01AC09 Epoprostenol (P) 0,011 g B01AC11 (I) 0,0487 g 0,15 mg 0,0007 B01AC11 Iloprost (P) 0,0043 g 50 mcg 0,0002 B01AC16 (P) 60,59 g 0,2 g 0,0006 B01AC21 (P) 0,04 g 0,0043 g <0,0001 B01AC24 Ticagrelor (O) 74047,68 g 0,18 g 0,8567 B01AC80 Acetylsalicylic acid + Magnesium oxide (O) 23333000 pieces 1 pieces 48,5910 B01AD Enzymes 0,0020 B01AD01 (P) 45000000 U 1500000 U 0,0001 B01AD02 (P) 74,57 g 0,1 g 0,0016 B01AD11 (P) 8 g 0,04 g 0,0004 B01AE Direct inhibitors 1,3603 B01AE07 etexilate (O) 195954,9 g 0,3 g 1,3603 B01AF Direct factor Xa inhibitors 6,5084 B01AF01 (O) 50382,58 g 0,02 g 5,2461 B01AF02 (O) 6061,75 g 10 mg 1,2624 B01AX Other antithrombotic agents 0,0102 B01AX05 sodium (P) 12,225 g 0,0025 g 0,0102 B02 0,1584 B02A ANTIFIBRINOLYTICS 0,1286 B02AA Amino acids 0,1286 B02AA01 Aminocaproic acid (P) 30385 g 16 g 0,0040 B02AA02 Tranexamic acid (O) 93100 g 2 g 0,0969 B02AA02 Tranexamic acid (P) 26600 g 2 g 0,0277 B02B VITAMIN K AND OTHER HEMOSTATICS 0,0298 B02BA Vitamin K 0,0077 B02BA01 (P) 37,99 g 0,02 g 0,0040 B02BA02 sodium bisulfite (P) 3,6 g 0,002 g 0,0037 B02BB Fibrinogen <0,0001 B02BB01 Fibrinogen (P) 10 g 5 g <0,0001

6/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

B02BC Local hemostatics B02BC81 Fibrinogen human+ Human thrombin (epil) 451 pieces B02BD Blood factors 0,0145 B02BD01 Human prothrombin complex (P) 192000 U 350 U 0,0011 B02BD02 Human coagulation factor VIII (P) 2276500 U 500 U 0,0095 B02BD03 Factor VIII inhibitor bypassing activity (P) 1808000 U 10000 U 0,0004 B02BD04 Human coagulation factor IX (P) 470600 U 350 U 0,0028 B02BD05 Human coagulation factor VII (P) 153000 U 6000 U 0,0001 Von Willebrand factor, human+ Human coagulation factor VIII B02BD06 2289580 U 7200 U 0,0007 (P) B02BD08 Eptacog alfa (activated) (P) 5450000 U 2500000 U <0,0001 B02BD81 Simoctocog alfa (P) 957750 U B02BX Other systemic hemostatics 0,0076 B02BX01 (P) 1822,5 g B02BX04 Romiplostim (P) 0,0075 g 30 mcg 0,0005 B02BX05 Eltrombopag (O) 170,1 g 50 mg 0,0071 B03 ANTIANEMIC PREPARATIONS 20,0481 B03A PREPARATIONS 3,3382 B03AA Iron bivalent, oral preparations 2,3665 B03AA07 Ferrous sulphate (O) 227271 g 0,2 g 2,3665 B03AB Iron trivalent, oral preparations B03AB03 Sodium feredetate (O) 76 g B03AB80 Iron (III) hydroxide polymaltose complex (O) 74434,5 g B03AC Iron, parenteral preparations 0,0514 B03AC01 Dextriferron (P) 125,5 g 0,1 g 0,0026 B03AC02 Iron (III) hydroxide sucrose complex (P) 934,5 g 0,1 g 0,0195 B03AC06 Iron (III)-hydroxide complex (P) 1288 g 0,1 g 0,0268 B03AC80 Iron (III) isomaltoside 1000 complex (P) 120 g 0,1 g 0,0025 B03AD Iron in combination with folic acid 0,9203 B03AD02 Ferrous fumarate+ Folic acid (O) 441920 pieces 1 pieces 0,9203 B03AE Iron in other combinations Ferrous gluconate+ gluconate+ Manganese gluconate B03AE81 1457600 ml (O) B03B VITAMIN B12 AND FOLIC ACID 16,0966 B03BA Vitamin B12 (cyanocobalamin and analogues) 6,5796 B03BA01 Cyanocobalamin (O) 3,7 g 1 mg 0,0077 B03BA01 Cyanocobalamin (P) 62,839 g 0,02 mg 6,5431 B03BA03 (P) 0,276 g 0,02 mg 0,0287 B03BB Folic acid and derivatives 9,5170 B03BB01 Folic acid (O) 1828 g 0,4 mg 9,5170 B03X OTHER ANTIANEMIC PREPARATIONS 0,6134 B03XA Other antianemic preparations 0,6134 B03XA02 Darbepoetin alfa (P) 0,8853 g 0,0045 mg 0,4097 B03XA03 Methoxy -epoetin beta (P) 0,1883 g 4 mcg 0,0980 B03XA80 Epoetin beta (P) 50724000 U 1000 U 0,1056 B05 BLOOD SUBSTITUTES AND PERFUSION B05A BLOOD AND RELATED PRODUCTS B05AA Blood substitutes and plasma fractions B05AA01 Albumin (P) 512802,5 g B05AA05 Dextran (P) 3200 ml B05AA06 Gelatin agents (P) 15155500 ml B05AA80 + Sodium chloride (P) 106500 ml B05AA81 Dextran+ Sodium chloride (P) 206000 ml Gelatine+ Sodium chloride+ Potassium chloride+ Magnesium B05AA83 2730000 ml chloride+ Sodium lactate (P) Hydroxyethyl starch+ Sodium chloride+ Potassium chloride+ B05AA84 dihydrate+ + Sodium 60000 ml acetate trihydrate+ Malic acid (P)

7/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

B05AA86 human plasma (P) 114000 ml B05B I.V. SOLUTIONS B05BA Solutions for parenteral B05BA01 Amino acids (P) 1392000 ml B05BA02 (P) 196000 ml B05BA03 Carbohydrates (P) 75950430 ml B05BA10 Combinations (P) 13625250 ml B05BA83 Amino acids+ Electrolytes+ Glucose (P) 94000 ml B05BB Solutions affecting the balance B05BB01 Electrolytes (P) 151614000 ml B05BB03 Trometamol (P) 400 ml B05BB82 Potassium chloride+ Glucose (P) 110000 ml B05BC Solutions producing osmotic diuresis B05BC01 (P) 1098000 ml B05C IRRIGATING SOLUTIONS B05CX Other irrigating solutions B05CX10 Combinations (NA) 180000 ml B05D PERITONEAL DIALYTICS B05DA Isotonic solutions B05DA80 Isotonic solutions (P) 7630000 ml B05DB Hypertonic solutions B05DB80 hypertonic solutions (P) 141176000 ml Amino acids+ Sodium chloride+ Calcium chloride dihydrate+ B05DB81 1900000 ml Magnesium chloride hexahydrate+ Sodium lactate (P) B05Z HEMODIALYTICS AND HEMOFILTRATES B05ZB Hemofiltrates Sodium chloride+ Potassium chloride+ Calcium chloride B05ZB80 dihydrate+ Magnesium chloride+ Glucose+ Sodium hydrogen 27780000 ml carbonate (P)

Calcium chloride dihydrate+ Magnesium chloride B05ZB82 hexahydrate+ Sodium chloride+ Sodium hydrogen carbonate+ 12790000 ml Potassium chloride+ Disodium phosphate dihydrate (P)

Calcium chloride dihydrate+ Magnesium chloride B05ZB84 hexahydrate+ + Sodium hydrogen carbonate+ 4560000 ml Sodium chloride (P) B05X I.V. ADDITIVES B05XA Electrolyte solutions B05XA01 Potassium chloride (P) 3563200 ml B05XA02 Sodium hydrogen carbonate (P) 1527500 ml B05XA03 Sodium chloride (P) 517867700 ml B05XA05 Magnesium sulphate (P) 17625 g B05XA05 Magnesium sulphate (P) 390100 ml B05XA07 Calcium chloride (P) 299800 ml B05XA14 , hydrated (P) 81600 ml B05XA80 Electrolytes (P) 77900 ml B05XB Amino acids B05XB02 Alanyl (P) 159100 ml B05XC Vitamins B05XC80 Vitamins (P) 155200 ml B06 OTHER HEMATOLOGICAL AGENTS 0,0002 B06A OTHER HEMATOLOGICAL AGENTS 0,0002 B06AA Enzymes B06AA03 Hyaluronidase (P) 15640 U B06AB Other hem products B06AB80 hemoderivate of calf blood, deproteinized (P) 50 pieces B06AB81 Hemin (P) 40 ml

8/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

B06AC Drugs usedin hereditary 0,0002 B06AC01 C1-inhibitor (P) 2000 U 1400 U <0,0001 B06AC02 Icatibant (P) 1,38 g 0,03 g 0,0001 B06AC04 Conestat alfa (P) 117600 U 3500 U 0,0001 C CARDIOVASCULAR SYSTEM 412,4971 C01 CARDIAC THERAPY 29,1803 C01A CARDIAC GLYCOSIDES 3,7541 C01AA Digitalis glycosides 3,7541 C01AA05 Digoxin (O) 446,7775 g 0,25 mg 3,7217 C01AA05 Digoxin (P) 3,7575 g 0,25 mg 0,0313 C01AA06 Lanatoside C (O) 0,54 g 0,001 g 0,0011 C01B ANTIARRHYTHMICS, CLASS I AND III 6,8728 C01BA Antiarrhythmics, class Ia C01BA80 Hydroquinidine (O) 234 g C01BB Antiarrhythmics, class Ib 0,1569 C01BB80 Aethacizin (O) 15070 g 0,2 g 0,1569 C01BC Antiarrhythmics, class Ic 4,0131 C01BC03 (O) 563295 g 0,3 g 3,9102 C01BC03 Propafenone (P) 736,05 g 0,3 g 0,0051 C01BC04 (O) 9380 g 0,2 g 0,0977 C01BC04 Flecainide (P) 12 g 0,2 g 0,0001 C01BD Antiarrhythmics, class III 2,7028 C01BD01 (O) 252102 g 0,2 g 2,6250 C01BD01 Amiodarone (P) 5767,95 g 0,2 g 0,0601 C01BD07 (O) 6816 g 0,8 g 0,0177 C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES 0,8721 C01CA Adrenergic and dopaminergic agents 0,8714 C01CA01 Etilefrine (O) 3,375 g 0,05 g 0,0001 C01CA02 (P) 0,459 g 0,09 g <0,0001 C01CA03 Norepinephrine (P) 325,78 g 0,006 g 0,1131 C01CA04 (P) 1692 g 0,5 g 0,0070 C01CA06 (P) 233 g 0,004 g 0,1213 C01CA07 Dobutamine (P) 898,75 g 0,5 g 0,0037 C01CA17 Midodrine (O) 8 g 0,03 g 0,0006 C01CA24 (I) 14,454 g C01CA24 Epinephrine (P) 140,582 g 0,5 mg 0,5855 C01CA26 (P) 960 g 0,05 g 0,0400 C01CE inhibitors 0,0005 C01CE02 (P) 12,5 g 0,05 g 0,0005 C01CX Other cardiac stimulants 0,0002 C01CX08 Levosimendan (P) 1,1125 g 11 mg 0,0002 C01CX80 (I) 1013680 ml C01D VASODILATORS USED IN CARDIAC DISEASES 7,9851 C01DA Organic 7,9778 C01DA02 Glyceryl trinitrate (P) 282,2 g C01DA02 Glyceryl trinitrate (SL) 629,468 g 0,0025 g 0,5243 C01DA05 Pentaerithrityl tetranitrate (O) 3 g 0,12 g 0,0001 C01DA08 (O) 12853,25 g 0,06 g 0,4461 C01DA08 Isosorbide dinitrate (SL) 123,0188 g 0,02 g 0,0128 C01DA14 Isosorbide mononitrate (O) 134347,2 g 0,04 g 6,9945 C01DX Other vasodilatators used in cardiac diseases 0,0073 C01DX80 Meldonium (O) 2625 g 0,75 g 0,0073 C01E OTHER CARDIAC PREPARATIONS 9,6962 C01EA 0,0004 C01EA01 Alprostadil (P) 0,1012 g 0,5 mg 0,0004 C01EB Other cardiac preparations 9,6958 C01EB10 (P) 73,332 g 0,015 g 0,0102 C01EB15 Trimetazidine (O) 180576,9 g 0,04 g 9,4013

9/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

C01EB16 (P) 0,76 g 0,03 g 0,0001 C01EB17 Ivabradine (O) 1248,1 g 0,01 g 0,2599 C01EB18 (O) 17047,5 g 1,5 g 0,0237 C01EB21 Regadenoson (P) 0,1328 g 0,4 mg 0,0007 C02 ANTIHYPERTENSIVES 3,9184 C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING 2,3988 C02AC Imidazoline receptor 2,3988 C02AC01 (O) 6,459 g 0,45 mg 0,0299 C02AC01 Clonidine (P) 5,622 g 0,45 mg 0,0260 C02AC05 Moxonidine (O) 337,5138 g 0,3 mg 2,3429 C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING 1,5035 C02CA Alpha-adrenoreceptor antagonists 1,5035 C02CA01 (O) 0,54 g 0,005 g 0,0002 C02CA04 (O) 2887,42 g 0,004 g 1,5033 C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON 0,0007 C02DD Nitroferricyanide derivatives 0,0007 C02DD01 Sodium nitroprusside (P) 15,75 g 0,05 g 0,0007 C02K OTHER ANTIHYPERTENSIVES 0,0154 C02KX Antihypertensives for pulmonary arterial hypertension 0,0154 C02KX01 Bosentan (O) 1001 g 0,25 g 0,0083 C02KX02 Ambrisentan (O) 18,3 g 7,5 mg 0,0051 C02KX05 Riociguat (O) 4,263 g 4,5 mg 0,0020 C03 24,8325 C03A LOW-CEILING DIURETICS, 2,1849 C03AA Thiazides, plain 2,1849 C03AA03 (O) 26229,5 g 0,025 g 2,1849 C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES 2,5232 C03BA Sulfonamides, plain 2,5232 C03BA08 Metolazone (O) 0,25 g 5 mg 0,0001 C03BA11 Indapamide (O) 3028,905 g 2,5 mg 2,5231 C03C HIGH-CEILING DIURETICS 16,9501 C03CA Sulfonamides, plain 16,9501 C03CA01 (O) 89098,2 g 0,04 g 4,6387 C03CA01 Furosemide (P) 5176,35 g 0,04 g 0,2695 C03CA04 Torasemide (O) 86164,95 g 0,015 g 11,9626 C03CA04 Torasemide (P) 571,7 g 0,015 g 0,0794 C03D POTASSIUM-SPARING AGENTS 3,1563 C03DA antagonists 3,1563 C03DA01 (O) 113244 g 0,075 g 3,1444 C03DA04 (O) 286,5 g 0,05 g 0,0119 DIURETICS AND POTASSIUM-SPARING AGENTS IN C03E 0,0179 COMBINATION C03EA Low-ceiling diuretics and potassium-sparing agents 0,0179 C03EA81 Hydrochlorothiazide+ (O) 8610 pieces 1 pieces 0,0179 C04 PERIPHERAL VASODILATORS 2,7837 C04A PERIPHERAL VASODILATORS 2,7837 C04AC Nicotinic acid and derivatives 0,0003 C04AC01 Nicotinic acid (P) 30 g 0,2 g 0,0003 C04AD derivatives 2,1277 C04AD02 Xantinol nicotinate (O) 504 g 0,9 g 0,0012 C04AD03 (O) 1018332 g 1 g 2,1207 C04AD03 Pentoxifylline (P) 843 g 0,3 g 0,0059 C04AX Other peripheral vasodilators 0,6557 C04AX21 Naftidrofuryl (O) 188905 g 0,6 g 0,6557 C05

10/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

AGENTS FOR TREATMENT OF AND ANAL C05A FISSURES FOR TOPICAL USE C05AA Corticosteroids C05AA82 + (R) 59136 pieces C05AA84 + Lidocaine (R) 167490 g C05AA84 Fluocortolone+ Lidocaine (R) 251520 pieces Other agents for treatment of hemorrhoids and anal fissures C05AX for topical use C05AX81 Xeroformium+ Zinc sulphate+ Extract of Belladonna (R) 9420 pieces C05AX83 cell extract+ Shark liver oil (R) 274320 pieces C05AX85 Hippopheae oleum (R) 240 pieces C05B ANTIVARICOSE THERAPY C05BA or for topical use C05BA01 Organo- (C) 197760 g C05BA03 Heparin sodium (C) 6948860 g C05BB Sclerosing agents for local injection C05BB02 Lauromacrogol 400 (P) 70,85 g C05C CAPILLARY STABILIZING AGENTS C05CA Bioflavonoids C05CA01 Rutoside (C) 559600 g C05CA01 Rutoside (O) 555285 pieces C05CA04 (C) 3117780 g C05CA04 Troxerutin (O) 234780 g C05CA53 + Hesperidine (O) 4650 pieces C05CX Other capillary stabilizing agents C05CX80 Vigne rouge extract (O) 9 g C05CX81 Aescin (O) 182160 pieces C07 BETA BLOCKING AGENTS 49,1348 C07A BETA BLOCKING AGENTS 49,1337 C07AA Beta blocking agents, non-selective 1,9772 C07AA05 (O) 42100 g 0,16 g 0,5480 C07AA07 (O) 109808,8 g 0,16 g 1,4292 C07AB Beta blocking agents, selective 46,4820 C07AB02 Metoprolol (O) 1708682,5 g 0,15 g 23,7222 C07AB02 Metoprolol (P) 82,35 g 0,15 g 0,0011 C07AB03 Atenolol (O) 28518,75 g 0,075 g 0,7919 C07AB07 Bisoprolol (O) 8591,925 g 0,01 g 1,7893 C07AB12 Nebivolol (O) 48445,49 g 0,005 g 20,1775 C07AG Alpha and beta blocking agents 0,6745 C07AG01 Labetalol (O) 18380 g 0,6 g 0,0638 C07AG01 Labetalol (P) 855,5 g 0,6 g 0,0030 C07AG02 Carvedilol (O) 10942,875 g 0,0375 g 0,6077 C07B BETA BLOCKING AGENTS AND THIAZIDES 0,0011 C07BB Beta blocking agents, selective, and thiazides 0,0011 C07BB07 Bisoprolol+ Hydrochlorothiazide (O) 540 pieces 1 pieces 0,0011 C08 BLOCKERS 54,6679 SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY C08C 52,5431 VASCULAR EFFECTS C08CA Dihydropyridine derivatives 52,5431 C08CA01 (O) 69345,9 g 0,005 g 28,8826 C08CA02 (O) 9742,5 g 0,005 g 4,0578 C08CA05 (O) 23039,32 g 0,03 g 1,5993 C08CA06 (O) 339 g 0,3 g 0,0024 C08CA06 Nimodipine (P) 2,2 g 0,05 g 0,0001 C08CA08 (O) 53950,12 g 0,02 g 5,6176 C08CA09 (O) 8919,848 g 0,004 g 4,6439 C08CA13 (O) 37164,6 g 0,01 g 7,7395

11/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT C08D 2,1248 CARDIAC EFFECTS C08DA Phenylalkylamine derivatives 2,0309 C08DA01 (O) 234038 g 0,24 g 2,0308 C08DA01 Verapamil (P) 17,1 g 0,24 g 0,0001 C08DB Benzothiazepine derivatives 0,0939 C08DB01 (O) 10819,8 g 0,24 g 0,0939 C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM 194,4623 C09A ACE INHIBITORS, PLAIN 81,2773 C09AA ACE inhibitors, plain 81,2773 C09AA01 Captopril (O) 1678 g 0,05 g 0,0699 C09AA02 Enalapril (O) 59921,1 g 0,01 g 12,4786 C09AA02 Enalapril (P) 8,475 g 0,01 g 0,0018 C09AA04 Perindopril (O) 5997,96 g 0,004 g 3,1227 C09AA05 Ramipril (O) 69127,495 g 2,5 mg 57,5832 C09AA06 Quinapril (O) 102 g 15 mg 0,0142 C09AA09 Fosinopril (O) 56280,28 g 0,015 g 7,8136 C09AA10 Trandolapril (O) 185,808 g 0,002 g 0,1935 C09B ACE INHIBITORS, COMBINATIONS 43,8597 C09BA ACE inhibitors and diuretics 27,8909 C09BA02 Enalapril+ Hydrochlorothiazide (O) 4711734 pieces 1 pieces 9,8122 C09BA04 Perindopril+ Indapamide (O) 6367950 pieces 1 pieces 13,2613 C09BA05 Ramipril+ Hydrochlorothiazide (O) 1464268 pieces 1 pieces 3,0493 C09BA06 Quinapril+ Hydrochlorothiazide (O) 660 pieces 1 pieces 0,0014 C09BA09 Fosinopril+ Hydrochlorothiazide (O) 848396 pieces 1 pieces 1,7668 C09BB ACE inhibitors and calcium channel blockers 9,9219 C09BB03 Lisinopril+ Amlodipine (O) 1070640 pieces 1 pieces 2,2296 C09BB04 Perindopril+ Amlodipine (O) 2429670 pieces 1 pieces 5,0598 C09BB07 Ramipril+ Amlodipine (O) 821940 pieces 1 pieces 1,7117 C09BB10 Trandolapril+ Verapamil (O) 442148 pieces 1 pieces 0,9208 C09BX ACE inhibitors, other combinations 6,0469 C09BX01 Perindopril+ Amlodipine+ Indapamide (O) 2903670 pieces 1 pieces 6,0469 C09C ANGIOTENSIN II ANTAGONISTS, PLAIN 40,8872 C09CA Angiotensin II antagonists, plain 40,8872 C09CA01 (O) 114062,7 g 0,05 g 4,7507 C09CA02 Eprosartan (O) 2570,4 g 0,6 g 0,0089 C09CA03 Valsartan (O) 186574,08 g 0,08 g 4,8568 C09CA06 Candesartan (O) 30780,976 g 0,008 g 8,0127 C09CA07 Telmisartan (O) 399330 g 0,04 g 20,7901 C09CA08 Olmesartan medoxomil (O) 23702,84 g 0,02 g 2,4681 C09D ANGIOTENSIN II ANTAGONISTS, COMBINATIONS 28,4380 C09DA Angiotensin II antagonists and diuretics 16,1946 C09DA01 Losartan+ Hydrochlorothiazide (O) 1138072 pieces 1 pieces 2,3700 C09DA03 Valsartan+ Hydrochlorothiazide (O) 936992 pieces 1 pieces 1,9513 C09DA06 Candesartan+ Hydrochlorothiazide (O) 867114 pieces 1 pieces 1,8058 C09DA07 Telmisartan+ Hydrochlorothiazide (O) 4617884 pieces 1 pieces 9,6167 C09DA08 Olmesartan medoxomil+ Hydrochlorothiazide (O) 216476 pieces 1 pieces 0,4508 C09DB Angiotensin II antagonists and calcium channel blockers 10,4249 C09DB01 Valsartan+ Amlodipine (O) 1652 pieces 1 pieces 0,0034 C09DB02 Olmesartan medoxomil+ Amlodipine (O) 1854636 pieces 1 pieces 3,8623 C09DB04 Telmisartan+ Amlodipine (O) 3090108 pieces 1 pieces 6,4352 C09DB07 Candesartan+ Amlodipine (O) 59556 pieces 1 pieces 0,1240 C09DX Angiotensin II antagonists, other combinations 1,8185 C09DX01 Valsartan+ Amlodipine+ Hydrochlorothiazide (O) 3864 pieces 1 pieces 0,0080 C09DX04 Valsartan+ Sacubitril (O) 728 pieces 1 pieces 0,0015

12/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

C09DX80 Olmesartan medoxomil+ Amlodipine+ Hydrochlorothiazide (O) 868616 pieces 1 pieces 1,8089 C10 MODIFYING AGENTS 53,5173 C10A LIPID MODIFYING AGENTS, PLAIN 53,0362 C10AA HMG CoA reductase inhibitors 52,3102 C10AA01 Simvastatin (O) 88553,72 g 0,03 g 6,1471 C10AA03 Pravastatin (O) 6030,32 g 0,03 g 0,4186 C10AA04 Fluvastatin (O) 20415,36 g 0,06 g 0,7086 C10AA05 (O) 168197,7 g 0,02 g 17,5136 C10AA07 Rosuvastatin (O) 132159,8 g 0,01 g 27,5223 C10AB Fibrates 0,4855 C10AB05 (O) 46622 g 0,2 g 0,4855 C10AC Bile acid sequestrants 0,0011 C10AC01 Colestyramine (O) 7200 g 14 g 0,0011 C10AX Other lipid modifying agents 0,2395 C10AX09 Ezetimibe (O) 1150,24 g 0,01 g 0,2395 C10AX80 Omega-3-acid ethyl esters 90 (O) 112336 pieces C10B LIPID MODIFYING AGENTS, COMBINATIONS 0,4811 C10BX HMG CoA reductase inhibitors, other combinations 0,4811 C10BX03 Atorvastatin+ Amlodipine (O) 205500 pieces 1 pieces 0,4280 C10BX11 Atorvastatin+ Amlodipine+ Perindopril (O) 25530 pieces 1 pieces 0,0532 D DERMATOLOGICALS 1,7752 D01 FOR DERMATOLOGICAL USE 1,1942 D01A ANTIFUNGALS FOR TOPICAL USE D01AC and derivatives D01AC01 (C) 1009180 g D01AC05 (C) 203480 g D01AC08 (C) 437995,8 g D01AC08 Ketoconazole (C) 1282080 ml D01AC80 Isoconazole+ (C) 624450 g D01AE Other antifungals for topical use D01AE14 (C) 1046,1 ml D01AE15 (C) 636666 g D01AE16 (C) 24030 ml D01AE22 (C) 343060 ml D01AE22 Naftifine (C) 345210 g D01B ANTIFUNGALS FOR SYSTEMIC USE 1,1942 D01BA Antifungals for systemic use 1,1942 D01BA01 (O) 552,5 g 0,5 g 0,0023 D01BA02 Terbinafine (O) 143083,5 g 0,25 g 1,1919 D02 EMOLLIENTS AND PROTECTIVES D02A EMOLLIENTS AND PROTECTIVES D02AB Zinc products D02AB80 (C) 469500 g D02AE Carbamide products D02AE01 (C) 110500 g D02AF preparations D02AF81 Salicylic acid+ Lactic acid (C) 208680 ml D02B PROTECTIVES AGAINST UV-RADIATION D02BA Protectives against UV-radiation for topical use D02BA01 4-Aminobenzoic acid (O) 2520 g PREPARATIONS FOR TREATMENT OF WOUNDS AND D03 ULCERS D03A CICATRIZANTS D03AX Other cicatrizants D03AX03 Dexpanthenol (C) 3712875 g D03AX81 Heparin sodium+ Allantoin+ Extract of Cepae (C) 131720 g D03AX83 Dexpanthenol+ (C) 1446750 g D03B ENZYMES

13/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

D03BA Proteolytic enzymes D03BA80 Collagenase+ (C) 210 g D05 ANTIPSORIATICS 0,0512 D05A ANTIPSORIATICS FOR TOPICAL USE D05AC Antracen derivatives D05AC01 (C) 6500 g D05AX Other antipsoriatics for topical use D05AX80 + (C) 729750 g D05B ANTIPSORIATICS FOR SYSTEMIC USE 0,0512 D05BB for treatment of 0,0512 D05BB02 (O) 860,4 g 0,035 g 0,0512 AND CHEMOTHERAPEUTICS FOR D06 DERMATOLOGICAL USE D06A ANTIBIOTICS FOR TOPICAL USE D06AA and derivatives D06AA04 Tetracycline (C) 1695 g D06AX Other antibiotics for topical use D06AX01 (C) 215955 g D06AX02 Chloramphenicol (C) 500 g D06AX13 (C) 1505 g D06AX80 + Neomycin (C) 144780 g D06AX84 Chloramphenicol+ Methyluracil (C) 8480 g D06B CHEMOTHERAPEUTICS FOR TOPICAL USE D06BA Sulfonamides D06BA01 (C) 1666250 g D06BB Antivirals D06BB02 (C) 70 g D06BB03 (C) 208576 g D06BB04 (C) 2598 ml D06BB06 (C) 34444 g D06BB10 (C) 4031 g D06BX Other chemotherapeutics D06BX01 Metronidazole (C) 178415 g D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS D07A CORTICOSTEROIDS, PLAIN D07AA Corticosteroids, weak (group I) D07AA02 Hydrocortisone (C) 780800 g D07AB Corticosteroids, moderately potent (group II) D07AB09 Triamcinolone (C) 78210 g D07AC Corticosteroids, potent (group III) D07AC01 Betamethasone (C) 299640 g D07AC04 acetonide (C) 600 g D07AC13 (C) 311720 ml D07AC13 Mometasone (C) 1065780 g D07AC14 aceponate (C) 580890 g D07AC17 (C) 56775 g D07AD Corticosteroids, very potent (group IV) D07AD01 (C) 94850 ml D07AD01 Clobetasol (C) 837350 g D07B CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS D07BA Corticosteroids, weak, combinations with antiseptics D07BA80 Hydrocortisone+ Chlorhexidine (C) 382540 g D07BC Corticosteroids, potent, combinations with antiseptics D07BC80 Betamethasone+ Salicylic acid (C) 850 g D07BC80 Betamethasone+ Salicylic acid (C) 805850 ml

14/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

D07C CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS D07CA Corticosteroids, weak, combinations with antibiotics D07CA83 Hydrocortisone+ Fusidic acid (C) 91320 g D07CC Corticosteroids, potent, combinations with antibiotics D07CC80 Betamethasone+ Fusidic acid (C) 553140 g D07X CORTICOSTEROIDS, OTHER COMBINATIONS D07XA Corticosteroids, weak, other combinations D07XA81 + Salicylic acid (C) 222300 ml D07XC Corticosteroids, potent, other combinations D07XC03 Mometasone+ Salicylic acid (C) 335880 g D08 ANTISEPTICS AND D08A ANTISEPTICS AND DISINFECTANTS D08AC Biguanides and amidines D08AC02 Chlorhexidine (C) 4000 ml D08AG products D08AG02 Povidone, iodinated (C) 969090 ml D08AG02 Povidone, iodinated (C) 3246330 g D08AG03 Iodine (C) 857460 ml D08AJ Quaternary ammonium compounds D08AJ81 Octenidine+ Phenoxyethanol (C) 7524200 ml D08AX Other antiseptics and disinfectants D08AX82 Tar+ Castor oil+ Xeroformium (C) 22260 g D08AX83 Brilliant Green (C) 327520 ml D10 ANTI- PREPARATIONS 0,4800 D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE D10AD Retinoids for topical use in acne D10AD01 (C) 23760 g D10AD03 (C) 147930 g D10AF Antiinfectives for treatment of acne D10AF01 (C) 499800 ml D10AF02 (C) 157050 ml D10AF81 Clindamycin+ Benzoyl (C) 91950 g D10AF82 Clindamycin+ Tretinoin (C) 220710 g D10AX Other anti-acne preparations for topical use D10AX03 (C) 399000 g D10B ANTI-ACNE PREPARATIONS FOR SYSTEMIC USE 0,4800 D10BA Retinoids for treatment of acne 0,4800 D10BA01 (O) 6914,4 g 0,03 g 0,4800 D11 OTHER DERMATOLOGICAL PREPARATIONS 0,0498 D11A OTHER DERMATOLOGICAL PREPARATIONS 0,0498 D11AH Agents for , excluding corticosteroids D11AH01 (C) 36480 g D11AH02 (C) 150750 g D11AX Other dermatologicals 0,0498 D11AX01 (C) 145260 ml D11AX10 (O) 23,912 g 0,001 g 0,0498 D11AX21 (C) 3510 g G GENITO AND SEX 54,5568 G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS 0,6660 ANTIINFECTIVES AND ANTISEPTICS, EXCL. G01A 0,6660 COMBINATIONS WITH CORTICOSTEROIDS G01AA Antibiotics 0,0655 G01AA10 Clindamycin (V) 3146 g 0,1 g 0,0655 G01AA80 + Neomycin+ B (V) 234 pieces G01AF Imidazole derivatives 0,6005 G01AF01 Metronidazole (V) 29538 g 0,5 g 0,1230 G01AF02 Clotrimazole (V) 16954,4 g 0,1 g 0,3531 G01AF05 (V) 5975,1 g 0,1 g 0,1244

15/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

G02 OTHER GYNECOLOGICALS 4,1324 G02A 0,0089 G02AB alkaloids 0,0033 G02AB01 (P) 0,317 g 0,2 mg 0,0033 G02AD Prostaglandins 0,0056 G02AD02 Dinoprostone (P) 0,32 g G02AD02 Dinoprostone (V) 1,3367 g 0,5 mg 0,0056 G02AD06 (O) 7,662 g G02B CONTRACEPTIVES FOR TOPICAL USE 2,9687 G02BA Intrauterine contraceptives 0,0150 G02BA03 (V) 7203 pieces 1 pieces 0,0150 G02BB Intravaginal contraceptives 2,9537 G02BB01 + (V) 49322 pieces 0,036 pieces 2,8531 G02BB80 Nonoxinol (V) 1056 pieces 1 pieces 0,0022 G02BB81 (V) 47230 pieces 1 pieces 0,0984 G02BB81 Benzalkonium chloride (V) 82368 g G02C OTHER GYNECOLOGICALS 1,1548 G02CA Sympathomimetics, labour repressants G02CA80 (P) 0,062 g G02CB Prolactine inhibitors 0,1718 G02CB01 (O) 372,375 g 0,005 g 0,1551 G02CB03 (O) 4,004 g 0,5 mg 0,0167 G02CX Other gynecologicals 0,9831 G02CX03 Agni casti fructus (O) 333630 pieces 1 pieces 0,6948 G02CX04 Cimicifugae rhizoma (O) 276870 pieces 2 pieces 0,2883 SEX HORMONES AND MODULATORS OF THE GENITAL G03 33,6187 SYSTEM G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE 27,3512 G03AA and , fixed combinations 23,0070 G03AA07 Levonorgestrel+ Ethinylestradiol (O) 67053 pieces 1 pieces 0,1396 G03AA09 + Ethinylestradiol (O) 715554 pieces 0,75 pieces 1,9869 G03AA10 + Ethinylestradiol (O) 101388 pieces 1 pieces 0,2111 G03AA10 Gestodene+ Ethinylestradiol (O) 2593374 pieces 0,75 pieces 7,2009 G03AA10 Gestodene+ Ethinylestradiol (TD) 10398 pieces 0,107 pieces 0,2024 G03AA12 + Ethinylestradiol (O) 976472 pieces 1 pieces 2,0335 G03AA12 Drospirenone+ Ethinylestradiol (O) 2237655 pieces 0,75 pieces 6,2132 G03AA13 Norelgestromin+ Ethinylestradiol (TD) 91782 pieces 0,107 pieces 1,7863 G03AA14 Nomegestrol+ (O) 32396 pieces 1 pieces 0,0675 G03AA15 Chlormadinone+ Ethinylestradiol (O) 245175 pieces 0,75 pieces 0,6808 G03AA16 + Ethinylestradiol (O) 196112 pieces 1 pieces 0,4084 G03AA16 Dienogest+ Ethinylestradiol (O) 747810 pieces 0,75 pieces 2,0764 G03AB Progestogens and estrogens, sequential preparations 0,4659 G03AB03 Levonorgestrel+ Ethinylestradiol (O) 123669 pieces 0,75 pieces 0,3434 G03AB05 Desogestrel+ Ethinylestradiol (O) 6666 pieces 0,75 pieces 0,0185 G03AB08 Dienogest+ Estradiol valerate (O) 49952 pieces 1 pieces 0,1040 G03AC Progestogens 3,8089 G03AC08 Etonogestrel (P) 50,048 g 68 mcg 1,5327 G03AC09 Desogestrel (O) 1093008 pieces 1 pieces 2,2762 G03AD Emergency contraceptives 0,0693 G03AD01 Levonorgestrel (O) 49,947 g 1,5 mg 0,0693 G03B 0,2040 G03BA 3-oxoandrosten (4) derivatives 0,2040 G03BA03 (C) 45 g 0,05 g 0,0019 G03BA03 Testosterone (O) 55,2 g 0,12 g 0,0010 G03BA03 Testosterone (P) 1738,5 g 0,018 g 0,2011 G03C ESTROGENS 1,5432 G03CA Natural and semisynthetic estrogens, plain 1,3770 G03CA03 Estradiol (C, V) 121100 g G03CA03 Estradiol (O) 635,404 g 2 mg 0,6616

16/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

G03CA03 Estradiol (TD) 3,9284 g 0,05 mg 0,1636 G03CA03 Estradiol (TD) 23,226 g 1 mg 0,0484 G03CA03 Estradiol (V) 2,3409 g 0,025 mg 0,1950 G03CA04 Estriol (V) 29,6175 g 0,2 mg 0,3084 G03CA80 Estradiol+ Prednisolone (C) 82300 g G03CX Other estrogens 0,1662 G03CX01 (O) 199,57 g 2,5 mg 0,1662 G03D PROGESTOGENS 1,4340 G03DA Pregnen (4) derivatives 0,7392 G03DA02 Medroxyprogesterone (O) 583,2 g 0,005 g 0,2429 G03DA02 Medroxyprogesterone (P) 558,45 g 0,007 g 0,1661 G03DA04 (O) 20727 g 0,3 g 0,1439 G03DA04 Progesterone (P) 229,625 g 0,005 g 0,0956 G03DA04 Progesterone (V) 3917,7 g 0,09 g 0,0907 G03DB Pregnadien derivatives 0,6948 G03DB01 Dydrogesterone (O) 2856,6 g 0,01 g 0,5949 G03DB08 Dienogest (O) 95,984 g 2 mg 0,0999 G03F PROGESTOGENS AND ESTROGENS IN COMBINATION 2,0536 G03FA Progestogens and estrogens, fixed combinations 1,5783 G03FA01 + Estradiol (O) 532196 pieces 1 pieces 1,1083 G03FA14 Dydrogesterone+ Estradiol (O) 71932 pieces 1 pieces 0,1498 G03FA17 Drospirenone+ Estradiol (O) 153748 pieces 1 pieces 0,3202 G03FB Progestogens and estrogens, sequential preparations 0,4753 G03FB05 Norethisterone+ Estradiol (O) 189028 pieces 1 pieces 0,3937 G03FB06 Medroxyprogesterone+ Estradiol (O) 252 pieces 1 pieces 0,0005 G03FB08 Dydrogesterone+ Estradiol (O) 38976 pieces 1 pieces 0,0812 G03G GONADOTROPINS AND OTHER OVULATION STIMULANTS 0,3387 G03GA Gonadotropins 0,1405 G03GA01 Chorionic gonadotrophin (P) 2455000 U 250 U 0,0205 G03GA02 Human menopausal gonadotropin (P) 108000 U 75 U 0,0030 G03GA05 Follitropin alfa (P) 3563775 U 75 U 0,0990 G03GA06 Follitropin beta (P) 107250 U 75 U 0,0030 G03GA07 Lutropin alfa (P) 305775 U 75 U 0,0085 G03GA08 Choriogonadotropin alfa (P) 0,7553 g 0,25 mg 0,0063 G03GA09 Corifollitropin alfa (P) 0,0158 g 0,15 mg 0,0002 G03GA30 Follitropin alfa+ Lutropin alfa (P) 60 ml 1 ml 0,0001 G03GB Ovulation stimulants, synthetic 0,1982 G03GB02 Clomifene (O) 856,5 g 0,009 g 0,1982 G03H 0,6154 G03HA Antiandrogens, plain 0,1630 G03HA01 (O) 7827,5 g 0,1 g 0,1630 G03HB Antiandrogens and estrogens 0,4524 G03HB01 Cyproterone+ (O) 162918 pieces 0,75 pieces 0,4524 OTHER SEX HORMONES AND MODULATORS OF THE G03X 0,0785 GENITAL SYSTEM G03XA Antigonadotropins and similar agents 0,0006 G03XA01 (O) 180 g 0,6 g 0,0006 G03XB Progesterone receptor modulators 0,0779 G03XB01 (O) 735 g 0,6 g 0,0026 G03XB02 Ulipristal (O) 180,88 g 5 mg 0,0753 G04 UROLOGICALS 16,1397 G04B UROLOGICALS 2,4487 G04BC Urinary concrement 0,0002 G04BC80 Extract of Lespedesa capita (O) 800 ml 10 ml 0,0002 G04BD Drugs for urinary frequency and incontinence 1,3237 G04BD04 (O) 5135,4 g 0,015 g 0,7130 G04BD06 (O) 22,05 g 0,03 g 0,0015

17/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

G04BD07 (O) 462,28 g 0,004 g 0,2407 G04BD08 (O) 78,9 g 0,005 g 0,0329 G04BD09 (O) 3572,55 g 0,04 g 0,1860 G04BD12 (O) 3593,25 g 50 mg 0,1497 G04BE Drugs used in 1,1125 G04BE01 Alprostadil (P) 0,038 g 0,02 mg 0,0040 G04BE01 Alprostadil (urethral) 1,893 g 0,25 mg 0,0158 G04BE03 (O) 20468,6 g 0,05 g 0,8525 G04BE08 (O) 784,1 g 0,01 g 0,1633 G04BE09 (O) 132,12 g 0,01 g 0,0275 G04BE10 (O) 2374,4 g 0,1 g 0,0494 G04BX Other urologicals 0,0123 G04BX14 Dapoxetin (O) 177,39 g 0,03 g 0,0123 G04BX80 Centaury+ Lovage root+ Rosemary leaf (O) 637680 pieces G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY 13,6910 G04CA Alpha-adrenoreceptor antagonists 10,9545 G04CA01 (O) 7061,7 g 7,5 mg 1,9608 G04CA02 (O) 1205,028 g 0,4 mg 6,2737 G04CA52 Tamsulosin+ (O) 1306110 pieces 1 pieces 2,7200 G04CB Testosterone-5-alpha reductase inhibitors 0,5203 G04CB01 Finasteride (O) 370,9 g 0,005 g 0,1545 G04CB02 Dutasteride (O) 87,825 g 0,5 mg 0,3658 G04CX Other drugs used in benign prostatic hypertrophy 2,2163 G04CX02 Sabalis serrulatae fructus (O) 340560 g 0,32 g 2,2163 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX H 26,8567 HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND H01 0,4048 ANALOGUES LOBE HORMONES AND H01A 0,1168 ANALOGUES H01AA ACTH 0,0003 H01AA02 Tetracosactide (P) 0,035 g 0,25 mg 0,0003 H01AB Thyrotropin 0,0009 H01AB01 Thyrotropin alfa (P) 2202,24 U 5 U 0,0009 H01AC Somatropin and somatropin agonists 0,1066 H01AC01 Somatropin (P) 102354,671 U 2 U 0,1066 H01AX Other anterior pituitary lobe hormones and analogues 0,0091 H01AX01 (P) 43,5 g 0,01 g 0,0091 H01B LOBE HORMONES 0,1895 H01BA and analogues 0,0996 H01BA01 Vasopressin injection (P) 5900 U 4 U 0,0031 H01BA02 (N) 0,0273 g 0,025 mg 0,0023 H01BA02 Desmopressin (P) 0,0406 g 0,004 mg 0,0212 H01BA02 Desmopressin (SL) 8,424 g 0,24 mg 0,0731 H01BB and analogues 0,0898 H01BB01 (O) 2875500 U 100 U 0,0599 H01BB02 Oxytocin (P) 215850 U 15 U 0,0300 H01C HYPOTHALAMIC HORMONES 0,0985 H01CA Gonadotropin-releasing hormones H01CA01 (P) 0,0037 g H01CB and analogues 0,0832 H01CB02 (P) 14,594 g 0,7 mg 0,0434 H01CB03 (P) 57,3 g 3 mg 0,0398 H01CC Anti-gonadotropin-releasing hormones 0,0153 H01CC01 (P) 1,458 g 0,25 mg 0,0121 H01CC02 (P) 0,3833 g 0,25 mg 0,0032 H02 CORTICOSTEROIDS FOR SYSTEMIC USE 7,5976

18/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN 7,5907 H02AA 0,1435 H02AA02 (O) 6,89 g 0,1 mg 0,1435 H02AB 7,4472 H02AB01 Betamethasone (P) 15,2019 g 1,5 mg 0,0211 H02AB02 Dexamethasone (O) 275,6 g 1,5 mg 0,3826 H02AB02 Dexamethasone (P) 647,9 g 1,5 mg 0,8995 H02AB04 Methylprednisolone (O) 6758,72 g 7,5 mg 1,8767 H02AB04 Methylprednisolone (P) 4995,13 g 0,02 g 0,5201 H02AB06 Prednisolone (O) 12310 g 0,01 g 2,5636 H02AB06 Prednisolone (P) 2409,3 g 0,01 g 0,5017 H02AB08 Triamcinolone (O) 29,76 g 7,5 mg 0,0083 H02AB08 Triamcinolone (P) 1570,4 g 7,5 mg 0,4360 H02AB09 Hydrocortisone (O) 2824 g 0,03 g 0,1960 H02AB09 Hydrocortisone (P) 598,1 g 0,03 g 0,0415 H02B CORTICOSTEROIDS FOR SYSTEMIC USE, COMBINATIONS 0,0069 H02BX Corticosteroids for systemic use, combinations 0,0069 H02BX80 Hydrocortisone+ Lidocaine (P) 99,625 g 0,03 g 0,0069 H03 THERAPY 18,8222 H03A THYROID PREPARATIONS 17,4125 H03AA 17,4125 H03AA01 Levothyroxine sodium (O) 1254,095 g 0,15 mg 17,4110 H03AA02 Liothyronine (O) 0,0435 g 0,06 mg 0,0015 H03B ANTITHYROID PREPARATIONS 1,4096 H03BA Thiouracils 0,6335 H03BA02 Propylthiouracil (O) 30420 g 0,1 g 0,6335 H03BB -containing imidazole derivatives 0,7761 H03BB02 Thiamazole (O) 3727 g 0,01 g 0,7761 H04 PANCREATIC HORMONES 0,0007 H04A GLYCOGENOLYTIC HORMONES 0,0007 H04AA Glycogenolytic hormones 0,0007 H04AA01 Glucagon (P) 0,36 g 0,001 g 0,0007 H05 CALCIUM 0,0313 H05B ANTI-PARATHYROID AGENTS 0,0313 H05BX Other anti-parathyroid agents 0,0313 H05BX01 (O) 729,12 g 0,06 g 0,0253 H05BX02 (O) 0,0058 g 2 mcg 0,0060 J ANTIINFECTIVES FOR SYSTEMIC USE 19,9030 J01 ANTIBACTERIALS FOR SYSTEMIC USE 13,7483 J01A 1,6034 J01AA Tetracyclines 1,6034 J01AA02 (O) 76930 g 0,1 g 1,6021 J01AA02 Doxycycline (P) 8 g 0,1 g 0,0002 J01AA08 (O) 42,5 g 0,2 g 0,0004 J01AA12 Tigecycline (P) 34,5 g 0,1 g 0,0007 J01C BETA-LACTAM ANTIBACTERIALS, 5,5988 J01CA Penicillins with extended spectrum 2,5692 J01CA01 (O) 7716 g 2 g 0,0080 J01CA01 Ampicillin (P) 24600 g 2 g 0,0256 J01CA04 (O) 1217464,5 g 1 g 2,5354 J01CA04 Amoxicillin (P) 100 g 1 g 0,0002 J01CE Beta-lactamase sensitive penicillins 0,1925 J01CE01 (P) 32910 g 3,6 g 0,0190 J01CE02 (O) 165981,6 g 2 g 0,1728 J01CE08 Benzathine benzylpenicillin (P) 1135,8 g 3,6 g 0,0007 J01CE30 Benzylpenicillin+ benzylpenicillin (P) 34,2 g 3,6 g <0,0001 J01CF Beta-lactamase resistant penicillins 0,1310 J01CF04 (P) 125750 g 2 g 0,1309

19/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

J01CF05 (O) 20 g 2 g <0,0001 J01CR Combinations of penicillins, incl. beta-lactamase inhibitors 2,7060 J01CR01 Ampicillin+ (P) 162234 g 2 g 0,1689 J01CR02 Amoxicillin+ (O) 1103751,95 g 1 g 2,2986 J01CR02 Amoxicillin+ Clavulanic acid (P) 147505 g 3 g 0,1024 J01CR04 (O) 74595 g 1,5 g 0,1036 J01CR05 + (P) 219088 g 14 g 0,0326 J01D OTHER BETA-LACTAM ANTIBACTERIALS 1,7250 J01DB First-generation 0,2291 J01DB04 (P) 104860 g 3 g 0,0728 J01DB05 (O) 150070 g 2 g 0,1563 J01DC Second-generation cephalosporins 1,3539 J01DC01 (P) 9200 g 6 g 0,0032 J01DC02 (O) 250179 g 0,5 g 1,0420 J01DC02 Cefuroxime (P) 336007,5 g 3 g 0,2332 J01DC10 (O) 36216 g 1 g 0,0754 J01DD Third-generation cephalosporins 0,0571 J01DD01 (P) 56730 g 4 g 0,0295 J01DD02 (P) 25731 g 4 g 0,0134 J01DD04 (P) 13590 g 2 g 0,0142 J01DE Fourth-generation cephalosporins 0,0209 J01DE01 (P) 20040 g 2 g 0,0209 J01DH 0,0642 J01DH02 (P) 26155 g 2 g 0,0272 J01DH03 (P) 9383 g 1 g 0,0195 J01DH51 + Cilastatin (P) 16710 g 2 g 0,0174 J01DI Other cephalosporins and J01DI54 Ceftolozane+ Tazobactam (P) 60 g J01E SULFONAMIDES AND 0,4493 J01EA Trimethoprim and derivatives 0,0254 J01EA01 Trimethoprim (O) 4875 g 0,4 g 0,0254 Combinations of sulfonamides and trimethoprim, incl. J01EE 0,4239 derivatives J01EE01 + Trimethoprim (O) 100 pieces 16 pieces <0,0001 J01EE01 Sulfamethoxazole+ Trimethoprim (O) 5660 pieces 4 pieces 0,0029 J01EE01 Sulfamethoxazole+ Trimethoprim (O) 361920 pieces 2 pieces 0,3768 J01EE01 Sulfamethoxazole+ Trimethoprim (O) 757200 ml 40 ml 0,0394 J01EE01 Sulfamethoxazole+ Trimethoprim (P) 44725 ml 20 ml 0,0047 J01F MACROLIDES, LINCOSAMIDES AND 2,4062 J01FA Macrolides 2,2071 J01FA02 Spiramycin (O) 110 g 3 g 0,0001 J01FA09 (O) 392845 g 0,5 g 1,6362 J01FA09 Clarithromycin (P) 2908,5 g 1 g 0,0061 J01FA10 (O) 81353,7 g 0,3 g 0,5647 J01FF Lincosamides 0,1991 J01FF01 Clindamycin (O) 105782,4 g 1,2 g 0,1836 J01FF01 Clindamycin (P) 13423,8 g 1,8 g 0,0155 J01G ANTIBACTERIALS 0,0327 J01GB Other 0,0327 J01GB01 (I) 119,168 g 0,112 g 0,0022 J01GB01 Tobramycin (I) 302,4 g 0,3 g 0,0021 J01GB01 Tobramycin (P) 32 g 0,24 g 0,0003 J01GB03 (P) 2552,45 g 0,24 g 0,0221 J01GB06 (P) 2870 g 1 g 0,0060 J01M QUINOLONE ANTIBACTERIALS 1,0124 J01MA Fluoroquinolones 1,0124 J01MA01 (O) 3632 g 0,4 g 0,0189

20/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

J01MA02 (O) 327145 g 1 g 0,6813 J01MA02 Ciprofloxacin (P) 14677,5 g 0,5 g 0,0611 J01MA06 (O) 77872 g 0,8 g 0,2027 J01MA12 (O) 9786 g 0,5 g 0,0408 J01MA12 Levofloxacin (P) 277 g 0,5 g 0,0012 J01MA14 (O) 1000 g 0,4 g 0,0052 J01MA14 Moxifloxacin (P) 248,8 g 0,4 g 0,0013 J01X OTHER ANTIBACTERIALS 0,9205 J01XA Glycopeptide antibacterials 0,0217 J01XA01 (P) 20830 g 2 g 0,0217 J01XB 0,0064 J01XB01 (I, P) 8860000000 U 3000000 U 0,0062 J01XB01 Colistin (P) 400000000 U 3000000 U 0,0003 J01XC Steroid antibacterials 0,0001 J01XC01 Fusidic acid (O) 100 g 1,5 g 0,0001 J01XD Imidazole derivatives 0,2987 J01XD01 Metronidazole (O) 243590 g 2 g 0,2536 J01XD01 Metronidazole (P) 32446 g 1,5 g 0,0450 J01XE derivatives 0,5866 J01XE01 (O) 56332 g 0,2 g 0,5866 J01XX Other antibacterials 0,0070 J01XX01 (O) 300 g 3 g 0,0002 J01XX01 Fosfomycin (P) 280 g 8 g 0,0001 J01XX07 Nitroxoline (O) 32,5 g 1 g 0,0001 J01XX08 (O) 3114 g 1,2 g 0,0054 J01XX08 Linezolid (P) 702 g 1,2 g 0,0012 J01XX09 (P) 7 g 0,28 g 0,0001 J01XX81 Dioxydine (P) 213 g J02 ANTIMYCOTICS FOR SYSTEMIC USE 0,3458 J02A ANTIMYCOTICS FOR SYSTEMIC USE 0,3458 J02AA Antibiotics 0,0089 J02AA01 Amphotericin (O) 360 g J02AA01 Amphotericin (P) 150,3 g 0,035 g 0,0089 J02AC Triazole derivatives 0,3315 J02AC01 (O) 12905,2 g 0,2 g 0,1344 J02AC01 Fluconazole (P) 2380,9 g 0,2 g 0,0248 J02AC02 (O) 15263 g 0,2 g 0,1589 J02AC03 (O) 1288 g 0,4 g 0,0067 J02AC03 Voriconazole (P) 115,2 g 0,4 g 0,0006 J02AC04 (O) 2346,6 g 0,8 g 0,0061 J02AX Other antimycotics for systemic use 0,0053 J02AX01 (O) 50 g 10 g <0,0001 J02AX04 Caspofungin (P) 85,65 g 0,05 g 0,0036 J02AX05 (P) 4,2 g 0,1 g 0,0001 J02AX06 (P) 79,7 g 0,1 g 0,0017 J04 0,3119 J04A DRUGS FOR TREATMENT OF 0,2929 J04AA Aminosalicylic acid and derivatives 0,0136 J04AA01 Paraaminosalicylic acid (O) 25080 g 12 g 0,0044 J04AA02 Sodium (O) 62100 g 14 g 0,0092 J04AB Antibiotics 0,0303 J04AB01 (O) 5100 g 0,75 g 0,0142 J04AB02 (O) 1650 g 0,6 g 0,0057 J04AB30 (P) 5016 g 1 g 0,0104 J04AC Hydrazides 0,0302 J04AC01 (O) 4350 g 0,3 g 0,0302 J04AK Other drugs for treatment of tuberculosis 0,1386 J04AK01 (O) 40000 g 1,5 g 0,0555 J04AK02 (O) 40000 g 1,2 g 0,0694

21/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

J04AK05 (O) 564 g 86 mg 0,0137 J04AK06 (O) 672 g J04AM Combinations of drugs for treatment of tuberculosis 0,0802 J04AM02 Rifampicin+ Isoniazid (O) 12000 pieces 4 pieces 0,0062 J04AM02 Rifampicin+ Isoniazid (O) 71000 pieces 2 pieces 0,0739 J04B DRUGS FOR TREATMENT OF LEPRA 0,0190 J04BA Drugs for treatment of lepra 0,0190 J04BA02 (O) 455 g 0,05 g 0,0190 J05 ANTIVIRALS FOR SYSTEMIC USE 5,4970 J05A DIRECT ACTING ANTIVIRALS 5,4970 and excl. J05AB 0,3184 inhibitors J05AB01 Aciclovir (O) 108671 g 4 g 0,0566 J05AB01 Aciclovir (P) 2836,25 g 4 g 0,0015 J05AB04 (O) 51156 g 1 g 0,1065 J05AB06 (P) 295 g 0,5 g 0,0012 J05AB11 (O) 208083 g 3 g 0,1444 J05AB12 (P) 3,75 g 0,025 g 0,0003 J05AB14 (O) 3368 g 0,9 g 0,0078 J05AD Phosphonic acid derivatives 0,0002 J05AD01 sodium (P) 600 g 6,5 g 0,0002 J05AE Protease inhibitors 0,1991 J05AE03 (O) 12489 g 1,2 g 0,0217 J05AE10 (O) 102156 g 1,2 g 0,1773 J05AE12 (O) 67,2 g 2,4 g 0,0001 J05AE14 (O) 4,2 g 0,15 g 0,0001 J05AF and reverse transcriptase inhibitors 0,0399 J05AF01 (O) 262 g 0,6 g 0,0009 J05AF01 Zidovudine (P) 45 g 0,6 g 0,0002 J05AF05 (O) 1305 g 0,3 g 0,0091 J05AF06 (O) 2343,6 g 0,6 g 0,0081 J05AF10 (O) 5,19 g 0,5 mg 0,0216 J05AG Non-nucleoside reverse transcriptase inhibitors 0,9864 J05AG01 (O) 4380 g 0,4 g 0,0228 J05AG03 (O) 188964 g 0,6 g 0,6559 J05AG05 (O) 3693,75 g 25 mg 0,3077 J05AH Neuraminidase inhibitors 0,1631 J05AH01 (I) 3,8 g 0,02 g 0,0004 J05AH02 (O) 11718 g 0,15 g 0,1627 J05AR Antivirals for treatment of HIV , combinations 3,4015 J05AR01 Zidovudine+ Lamivudine (O) 227580 pieces 2 pieces 0,2370 J05AR02 Lamivudine+ Abacavir (O) 544860 pieces 1 pieces 1,1347 J05AR03 + (O) 485250 pieces 1 pieces 1,0105 J05AR10 + Ritonavir (O) 223824 g 0,8 g 0,5826 J05AR14 Darunavir+ (O) 209670 pieces 1 pieces 0,4366 J05AX Other antivirals 0,3887 J05AX08 (O) 48558 g 0,8 g 0,1264 J05AX09 (O) 810 g 0,6 g 0,0028 J05AX12 (O) 1203 g 50 mg 0,0501 J05AX16 (O) 25172 g 0,5 g 0,1048 J05AX67 + + Ritonavir (O) 100352 pieces 2 pieces 0,1045 J06 IMMUNE SERA AND IMMUNOGLOBULINS J06A IMMUNE SERA J06AA Immune sera J06AA01 (P) 20 pieces J06AA03 (P) 41 pieces J06B IMMUNOGLOBULINS J06BA Immunoglobulins, normal human

22/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

J06BA01 Immunoglobulins, normal human, for extravascular a (P) 16259,1 g

J06BA02 Immunoglobulins, normal human, for intravascular a (P) 50435 g J06BB Specific immunoglobulins J06BB01 Human Anti-D Immunoglobulin (P) 1992500 U J06BB02 immunoglobulin (P) 37000 U J06BB03 Varicella zoster immunoglobulin (P) 2500 U J06BB04 B immunoglobulin (P) 2680 U J06BB09 immunoglobulin (P) 60000 U J06BB16 (P) 48 g J07 J07A BACTERIAL VACCINES J07AE Cholera vaccines J07AE01 Cholera, inactivated, whole cell (O) 30 doses J07AG Hemophilus influenzae B vaccines J07AG01 Haemophilus influenzae B, purified conjugated (P) 136 pieces J07AH Meningococcal vaccines Meningococcus, tetravalent purified polysaccharides antigen J07AH08 346 doses conjugated (P) J07AH09 Meningococcus B, multicomponent (P) 54 doses J07AL Pneumococcal vaccines J07AL01 Pneumococcus, purified polysaccharides antigen (P) 424 doses Pneumococcus, purified polysaccharides antigen conjugated J07AL02 1721 doses (P) Pneumococcus, purified polysaccharides antigen+ J07AL52 441 doses Haemophilus influenzae, conjugated (P) J07AM Tetanus vaccines J07AM51 Tetanus toxoid+ Diphtheria toxoid (P) 30310 doses J07AN Tuberculosis vaccines J07AN01 Tuberculosis, live attenuated (P) 22700 doses J07AP Typhoid vaccines J07AP03 Typhoid, purified polysaccharide antigen (P) 2129 doses J07AX Other bacterial vaccines J07AX80 Diphtheria-tetanus-pertussis (P) 12770 doses J07B VIRAL VACCINES J07BA Encephalitis vaccines J07BA01 Encephalitis, tick borne, inactivated, whole (P) 64518 doses J07BB vaccines J07BB02 Influenza, inactivated, split virus or surface antigen (P) 50355 doses J07BC Hepatitis vaccines J07BC01 , purified antigen (P) 43459 doses J07BC02 Hepatitis A, inactivated, whole virus (P) 5252 doses Hepatitis A, inactivated, whole virus+ Hepatitis B, purified J07BC80 3481 doses antigen (P) J07BD vaccines Measles, live attunated+ , live attenuated+ Mumps, J07BD52 25091 doses live,attenuated (P) J07BF Poliomyelitis vaccines J07BF03 Poliomyelitis, trivalent, inactivated, whole virus (P) 898 doses J07BG vaccines J07BG01 Rabies, inactivated, whole virus (P) 2813 doses J07BH Rota virus vaccines J07BH01 Rota virus, live attenuated (O) 26081 doses J07BH02 Rota virus, pentavalent, live, reassorted (O) 1786 doses J07BK Varicella zoster vaccines J07BK01 Varicella, live attenuated (P) 700 doses

23/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

J07BK02 Zoster, live attenuated (P) 11 doses J07BL Yellow vaccines J07BL01 Yellow fever, live attenuated (P) 1362 doses J07BM Papillomavirus vaccines J07BM01 Papillomavirus (human types 6, 11, 16, 18) (P) 483 doses J07BM02 Papillomavirus (human types 16, 18) (P) 424 doses Papillomavirus (human types 6, 11, 16, 18, 31, 33, 45, 52, 58) J07BM03 1115 doses (P) J07C BACTERIAL AND VIRAL VACCINES, COMBINED J07CA Bacterial and viral vaccines, combined Diphtheria toxoid+ Pertussis, purified antigen+ Tetanus J07CA02 14820 doses toxoid+ Poliomyelitis, trivalent, inactivated, whole virus (P)

Diphtheria toxoid+ Tetanus toxoid+ Pertussis, purified J07CA06 antigen+ Poliomyelitis, trivalent, inactivated, whole virus+ 52890 doses Haemophilus influenzae B, purified antigen conjugated (P) L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS 10,7432 L01 ANTINEOPLASTIC AGENTS L01A ALKYLATING AGENTS L01AA Nitrogen mustard analogues L01AA01 Cyclophosphamide (O) 780 g L01AA01 Cyclophosphamide (P) 4157,8 g L01AA02 Chlorambucil (O) 30,8 g L01AA03 Melphalan (O) 15 g L01AA03 Melphalan (P) 24,45 g L01AA06 Ifosfamide (P) 2491,5 g L01AA07 Trofosfamide (O) 5 g L01AA09 Bendamustine (P) 109,7 g L01AB Alkyl sulfonates L01AB01 Busulfan (O) 4 g L01AB01 Busulfan (P) 9,12 g L01AB02 Treosulfan (P) 850 g L01AD Nitrosoureas L01AD01 Carmustine (P) 11,5 g L01AD02 Lomustine (O) 28 g L01AX Other alkylating agents L01AX03 Temozolomide (O) 725,85 g L01AX04 Dacarbazine (P) 410 g L01B ANTIMETABOLITES L01BA Folic acid analogues L01BA01 (P) 1123,87 g L01BA04 Pemetrexed (P) 314,4 g L01BB Purine analogues L01BB02 Mercaptopurine (O) 313,75 g L01BB03 Tioguanine (O) 10 g L01BB04 Cladribine (P) 0,6 g L01BB05 Fludarabine (O) 1 g L01BB05 Fludarabine (P) 25,5 g L01BC analogues L01BC01 (P) 2591,5 g L01BC02 Fluorouracil (P) 14115 g L01BC05 Gemcitabine (P) 4841,828 g L01BC06 Capecitabine (O) 272802 g L01BC07 Azacitidine (P) 84 g L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS L01CA Vinca alkaloids and analogues

24/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

L01CA01 Vinblastine (P) 2,68 g L01CA02 Vincristine (P) 2,254 g L01CA04 Vinorelbine (P) 9,5 g L01CB Podophyllotoxin derivatives L01CB01 Etoposide (O) 355 g L01CB01 Etoposide (P) 537,5 g L01CD Taxanes L01CD01 Paclitaxel (P) 657,9 g L01CD02 Docetaxel (P) 383,52 g L01CD04 Cabazitaxel (P) 7,8 g L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES L01DA Actinomycines L01DA01 Dactinomycin (P) 0,025 g L01DB Anthracyclines and related substances L01DB01 (P) 117,5 g L01DB02 Daunorubicin (P) 11,82 g L01DB03 Epirubicin (P) 320,35 g L01DB06 Idarubicin (O) 0,06 g L01DB06 Idarubicin (P) 2,275 g L01DB07 Mitoxantrone (P) 3,36 g L01DB11 Pixantrone (P) 2,088 g L01DC Other cytotoxic antibiotics L01DC01 Bleomycin (P) 5805000 U L01DC03 Mitomycin (P) 4,62 g L01X OTHER ANTINEOPLASTIC AGENTS L01XA compounds L01XA01 (P) 247,8 g L01XA02 (P) 1813,35 g L01XA03 (P) 801,8 g L01XB Methylhydrazines L01XB01 Procarbazine (O) 77,5 g L01XC Monoclonal L01XC02 (P) 1215,7 g L01XC03 (P) 1545,45 g L01XC06 (P) 47,4 g L01XC07 (P) 1326,5 g L01XC08 (P) 79,7 g L01XC10 (P) 85,7 g L01XC12 (P) 4,1 g L01XC13 (P) 4,2 g L01XC14 (P) 6,34 g L01XC17 (P) 0,56 g L01XC18 (P) 7,1 g L01XC21 (P) 1,7 g L01XC24 (P) 24 g L01XD Sensitizers used in photodynamic/radiation therapy L01XD04 Aminolevulinic acid (O) 7,5 g L01XE Protein kinase inhibitors L01XE01 (O) 13128 g L01XE02 (O) 892,5 g L01XE03 (O) 558 g L01XE04 (O) 346,85 g L01XE05 (O) 4771,2 g L01XE06 (O) 552 g L01XE07 (O) 507,5 g L01XE08 (O) 6675,2 g L01XE09 (P) 2,82 g L01XE10 (O) 8,85 g

25/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

L01XE11 (O) 7776 g L01XE12 (O) 72 g L01XE13 (O) 115,92 g L01XE14 (O) 126 g L01XE16 (O) 390 g L01XE17 (O) 62,328 g L01XE18 (O) 115,92 g L01XE21 (O) 40,32 g L01XE23 Dabrafenib (O) 1035 g L01XE24 (O) 4,05 g L01XE27 (O) 1512 g L01XE31 (O) 2259 g L01XE35 (O) 48 g L01XX Other antineoplastic agents L01XX01 Amsacrine (P) 3 g L01XX02 Asparaginase (P) 700000 U L01XX05 (O) 203250 g L01XX11 Estramustine (O) 378 g L01XX14 Tretinoin (O) 10 g L01XX17 Topotecan (P) 3,915 g L01XX19 Irinotecan (P) 634,4 g L01XX23 (O) 750 g L01XX24 Pegaspargase (P) 18750 U L01XX32 Bortezomib (P) 4,2595 g L01XX35 (O) 0,6 g L01XX41 Eribulin (P) 0,11 g L01XX46 Olaparib (O) 604,8 g L01XX50 Ixazomib (O) 0,387 g L02 ENDOCRINE THERAPY 4,7600 L02A HORMONES AND RELATED AGENTS 0,4414 L02AB Progestogens 0,0112 L02AB02 Medroxyprogesterone (O) 5385 g 1 g 0,0112 L02AE Gonadotropin releasing analogues 0,4301 L02AE01 (N) 5,7 g 1,2 mg 0,0099 L02AE03 Goserelin (P) 5,9832 g 0,129 mg 0,0966 L02AE04 (P) 20,8267 g 0,134 mg 0,3237 L02B HORMONE ANTAGONISTS AND RELATED AGENTS 4,3187 L02BA Anti-estrogens 0,7743 L02BA01 Tamoxifen (O) 6162 g 0,02 g 0,6416 L02BA03 (P) 529 g 8,3 mg 0,1327 L02BB Anti-androgens 2,0402 L02BB03 (O) 40584,6 g 0,05 g 1,6903 L02BB04 26,88 g 0,16 mg 0,3499 (O) L02BG Aromatase inhibitors 1,4557 L02BG03 Anastrozole (O) 224,476 g 1 mg 0,4675 L02BG04 Letrozole (O) 1020,825 g 2,5 mg 0,8503 L02BG06 (O) 1655,25 g 0,025 g 0,1379 L02BX Other hormone antagonists and related agents 0,0484 L02BX03 Abiraterone (O) 23250 g 1 g 0,0484 L03 IMMUNOSTIMULANTS 0,9522 L03A IMMUNOSTIMULANTS 0,9522 L03AA Colony stimulating factors 0,0503 L03AA02 Filgrastim (P) 5,1166 g 0,35 mg 0,0304 L03AA13 Pegfilgrastim (P) 2,862 g 0,3 mg 0,0199 L03AB 0,7551 L03AB03 gamma (P) 0,0024 g 40 mcg 0,0001 L03AB04 Interferon alfa-2a (P) 28824000000 U 2000000 U 0,0300 L03AB07 Interferon beta-1a (P) 1,0443 g 0,0043 mg 0,5058

26/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

L03AB08 Interferon beta-1b (P) 1,782E+11 U 4000000 U 0,0928 L03AB10 Peginterferon alfa-2b (P) 0,1474 g 0,0075 mg 0,0409 L03AB11 Peginterferon alfa-2a (P) 0,9586 g 0,026 mg 0,0768 L03AB13 Peginterferon beta-1a (P) 0,0374 g 8,9 mcg 0,0088 L03AX Other immunostimulants 0,1467 L03AX03 BCG (P) 3,1875 g 1,8 mg 0,0037 L03AX13 Glatiramer acetate (P) 1367,68 g 0,02 g 0,1424 L03AX15 Mifamurtide (P) 0,2 g 0,7 mg 0,0006 L03AX16 Plerixafor (P) 0,312 g 16,8 mg <0,0001 L03AX80 Methyluracil (O) 2000 g L03AX80 Methyluracil (R) 325 g L04 IMMUNOSUPPRESSANTS 5,0310 L04A IMMUNOSUPPRESSANTS 5,0310 L04AA Selective immunosuppressants 0,8319 L04AA04 Rabbit anti-T-lymphocyte immunoglobulin (P) 10,25 g 0,1 g 0,0002 L04AA06 Mycophenolic acid (O) 234271,2 g 2 g 0,2439 L04AA06 Mycophenolic acid (P) 240 g 2 g 0,0002 L04AA10 Sirolimus (O) 19,23 g 0,003 g 0,0133 L04AA13 (O) 4153,5 g 0,02 g 0,4325 L04AA18 Everolimus (O) 0,5 g 1,5 mg 0,0007 L04AA23 Natalizumab (P) 105,3 g 0,01 g 0,0219 L04AA24 Abatacept (P) 87,75 g 0,027 g 0,0068 L04AA26 Belimumab (P) 3,6 g 25 mg 0,0003 L04AA27 Fingolimod (O) 5,306 g 0,5 mg 0,0221 L04AA31 Teriflunomide (O) 493,528 g 14 mg 0,0734 L04AA33 Vedolizumab (P) 27,3 g 5,4 mg 0,0105 L04AA34 (P) 0,372 g 0,13 mg 0,0060 L04AB Tumor factor alpha (TNF-alpha) inhibitors 0,7730 L04AB01 Etanercept (P) 449,48 g 0,007 g 0,1337 L04AB02 (P) 675,7 g 3,75 mg 0,3752 L04AB04 Adalimumab (P) 235,76 g 2,9 mg 0,1693 L04AB05 Certolizumab pegol (P) 42 g 14 mg 0,0062 L04AB06 Golimumab (P) 70,55 g 1,66 mg 0,0885 L04AC inhibitors 0,0627 L04AC02 Basiliximab (P) 1,56 g 0,04 g 0,0001 L04AC03 Anakinra (P) 101,304 g 0,1 g 0,0021 L04AC05 (P) 9,495 g 0,54 mg 0,0366 L04AC07 Tocilizumab (P) 229,64 g 0,02 g 0,0239 L04AC07 Tocilizumab (P) 416,016 g L04AC10 Secukinumab (P) 89,7 g L04AD Calcineurin inhibitors 0,3930 L04AD01 (O) 30016,25 g 0,25 g 0,2500 L04AD01 Ciclosporin (P) 139,5 g 0,25 g 0,0012 L04AD02 Tacrolimus (O) 339,825 g 5 mg 0,1415 L04AD02 Tacrolimus (P) 0,6 g 5 mg 0,0002 L04AX Other immunosuppressants 2,9703 L04AX01 (O) 23115 g 0,15 g 0,3209 L04AX02 (O) 1149,4 g 0,1 g 0,0239 L04AX03 Methotrexate (O) 3089,75 g 2,5 mg 2,5738 L04AX04 Lenalidomide (O) 196,56 g 0,01 g 0,0409 L04AX05 Pirfenidone (O) 12178,404 g 2,4 g 0,0106 Pomalidomide L04AX06 0,336 g 3 mg 0,0002 (O) M MUSCULO-SKELETAL SYSTEM 79,4933 M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS 68,6148 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, M01A 68,6087 NON-STEROIDS M01AB derivatives and related substances 10,7441

27/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

M01AB01 (O) 4835 g 0,1 g 0,1007 M01AB05 (O) 458992,125 g 0,1 g 9,5585 M01AB05 Diclofenac (P) 15602,625 g 0,1 g 0,3249 M01AB05 Diclofenac (R) 20578,5 g 0,1 g 0,4285 M01AB15 (P) 1,2 g 30 mg 0,0001 M01AB16 (O) 27470 g 0,2 g 0,2860 M01AB80 Diclofenac+ Misoprostol (O) 1755 g 0,1 g 0,0365 M01AB82 Diclofenac+ Omeprazole (O) 418,5 g 0,1 g 0,0087 M01AC 5,3064 M01AC01 (O) 2064,8 g 0,02 g 0,2150 M01AC05 (O) 4566,88 g 0,012 g 0,7925 M01AC05 Lornoxicam (P) 22,36 g 0,012 g 0,0039 M01AC06 (O) 30612,3 g 0,015 g 4,2500 M01AC06 Meloxicam (P) 324,025 g 0,015 g 0,0450 M01AE Propionic acid derivatives 37,1721 M01AE01 Ibuprofen (O) 15177316 g 1,2 g 26,3390 M01AE02 (O) 434217,75 g 0,5 g 1,8085 M01AE03 (O) 95330,125 g 0,15 g 1,3235 M01AE03 Ketoprofen (P) 15444 g 0,15 g 0,2144 M01AE17 (O) 61532,25 g 0,075 g 1,7085 M01AE17 Dexketoprofen (P) 5059,75 g 0,075 g 0,1405 M01AE52 Naproxen+ Esomeprazole (O) 1353585 g 0,5 g 5,6377 M01AG Fenamates 0,0056 M01AG02 (O) 810 g 0,3 g 0,0056 M01AH Coxibs 6,0684 M01AH01 (O) 60866 g 0,2 g 0,6338 M01AH05 (O) 156578,73 g 60 mg 5,4346 M01AX Other antiinflammatory and antirheumatic agents, non-steroids 9,3121 M01AX01 (O) 214180 g 1 g 0,4460 M01AX05 (O) 6386137,98 g 1,5 g 8,8661 M01C SPECIFIC ANTIRHEUMATIC AGENTS 0,0061 M01CC and similar agents 0,0061 M01CC01 Penicillamine (O) 1462,5 g 0,5 g 0,0061 M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN

M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN

M02AA Antiinflammatory preparations, non-steroids for topical use M02AA07 Piroxicam (C) 34225 g M02AA10 Ketoprofen (C) 1496700 g M02AA12 Naproxen (C) 888855 g M02AA13 Ibuprofen (C) 1368050 g M02AA15 Diclofenac (C) 35527840 g M02AA15 Diclofenac (TD) 306255 pieces M02AA81 Ibuprofen+ Levomenthol (C) 1621950 g M02AC Preparations with salicylic acid derivatives + Levomenthol+ Eucalyptus oil+ Turpentine M02AC80 136345 g oil (C) M02AX Other topical products for joint and muscular pain M02AX80 Nicoboxil+ Nonivamide (C) 201020 g M02AX86 + Methyl salicylate+ Levomenthol (C) 67380 g Camphor+ Salicylic acid+ Turpentine oil+ Venenum Viperae M02AX90 1251450 g berus (C) Benzyl nicotinate+ Nonivamide+ Camphor+ Turpentine oil+ M02AX92 1169370 g Dimethyl (C) M03 MUSCLE RELAXANTS 0,8974

28/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

M03A MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS M03AB Choline derivatives M03AB01 (P) 3779,5 g M03AC Other quaternary ammonium compounds M03AC04 (P) 1894 g M03AC06 Pipecuronium (P) 39,5 g M03AC09 (P) 667 g M03AX Other muscle relaxants, peripherally acting agents M03AX01 (P) 972100 U M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS 0,8974 M03BX Other centrally acting agents 0,8974 M03BX01 (O) 3885,75 g 0,05 g 0,1618 M03BX01 Baclofen (P) 0,6008 g 0,55 mg 0,0023 M03BX02 Tizanidine (O) 4216,86 g 0,012 g 0,7318 M03BX04 (O) 139,5 g 0,2 g 0,0015 M04 ANTIGOUT PREPARATIONS 5,3512 M04A ANTIGOUT PREPARATIONS 5,3512 M04AA Preparations inhibiting production 5,3362 M04AA01 (O) 863835 g 0,4 g 4,4973 M04AA03 (O) 32225,76 g 0,08 g 0,8389 M04AB Preparations increasing uric acid 0,0118 M04AB01 (O) 50 g 1 g 0,0001 M04AB03 (O) 560 g 0,1 g 0,0117 M04AC Preparations with no effect on uric acid metabolism 0,0032 M04AC01 (O) 1,55 g 1 mg 0,0032 M05 DRUGS FOR TREATMENT OF BONE DISEASES 4,6300 DRUGS AFFECTING BONE STRUCTURE AND M05B 4,6300 MINERALIZATION M05BA Bisphosphonates 1,0851 M05BA03 Pamidronic acid (P) 18,63 g 0,06 g 0,0006 M05BA04 Alendronic acid (O) 1634,36 g 0,01 g 0,3404 M05BA06 Ibandronic acid (O) 1163,55 g 0,005 g 0,4846 M05BA06 Ibandronic acid (P) 3,72 g 0,006 g 0,0013 M05BA07 Risedronic acid (O) 602,42 g 0,005 g 0,2509 M05BA08 Zoledronic acid (P) 13,94 g 0,004 g 0,0073 M05BB Bisphosphonates, combinations 2,7595 M05BB03 Alendronic acid+ Colecalciferol (O) 13250,72 g 10 mg 2,7595 M05BX Other drugs affecting bone structure and mineralization 0,7854 M05BX03 ranelate (O) 33320 g 2 g 0,0347 M05BX04 Denosumab (P) 118,963 g 0,33 mg 0,7507 N NERVOUS SYSTEM 118,3053 N01 N01A ANESTHETICS, GENERAL N01AB Halogenated hydrocarbons N01AB06 (I) 57700 ml N01AB07 (I) 61440 ml N01AB08 (I) 680000 ml N01AF , plain N01AF03 Thiopental (P) 3525 g N01AH Opioid anesthetics N01AH01 Fentanyl (P) 46,7 g N01AH06 Remifentanil (P) 11,12 g N01AX Other general anesthetics N01AX03 (P) 82 g N01AX07 Etomidate (P) 70 g N01AX10 Propofol (P) 58898 g N01AX11 (P) 4760 g N01AX13 (I) 13394000 ml

29/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

N01AX14 (P) 101 g N01B ANESTHETICS, LOCAL N01BA Esters of aminobenzoic acid N01BA02 Procaine (P) 6 g N01BB N01BB01 (Infilt, P) 2969,05 g N01BB01 Bupivacaine (P) 217 g N01BB02 Lidocaine (C) 30365 g N01BB02 Lidocaine (NA) 159000 ml N01BB02 Lidocaine (P) 24375 g N01BB03 (dental) 1660,5 g N01BB08 (P) 1,6 g N01BB09 (P) 263 g N01BB80 Articaine+ Epinephrine (dental) 1176655 ml N01BB80 Articaine+ Epinephrine (O) 142470 ml N01BB81 Bupivacaine+ Epinephrine (P) 346700 ml N01BB82 Lidocaine+ Epinephrine (P) 66080 ml N01BB83 Lidocaine+ (C) 48975 g N01BB86 Lidocaine+ Chlorhexidine (urethral) 1100300 g N01BB87 Mepivacaine+ Epinephrine (P) 90 ml N01BB89 Lidocaine+ (dental) 32040 ml N01BC Esters of N01BC01 (C) 525 g N02 18,9830 N02A 5,3172 N02AA Natural alkaloids 3,0032 N02AA01 (O) 6774,3 g 0,1 g 0,1411 N02AA01 Morphine (P) 686,7 g 0,03 g 0,0477 N02AA05 (O) 11671,37 g 0,075 g 0,3241 N02AA08 (O) 6166,8 g 0,15 g 0,0856 N02AA80 + (O) 3463780 pieces 3 pieces 2,4044 N02AA81 Oxycodone+ Naloxone (O) 10,35 g 75 mg 0,0003 N02AB Phenylpiperidine derivatives 0,1230 N02AB02 (P, V) 3418,5 g 0,4 g 0,0178 N02AB03 Fentanyl (O) 5,1452 g N02AB03 Fentanyl (SL) 4,355 g 0,6 mg 0,0151 N02AB03 Fentanyl (TD) 51,9156 g 1,2 mg 0,0901 N02AX Other opioids 2,1910 N02AX02 (O) 304786,5 g 0,3 g 2,1157 N02AX02 Tramadol (P) 6374 g 0,3 g 0,0442 N02AX02 Tramadol (R) 789,5 g 0,3 g 0,0055 N02AX52 Tramadol+ Paracetamol (O) 1838,625 g 150 mg 0,0255 N02B OTHER ANALGESICS AND ANTIPYRETICS 12,9647 N02BA Salicylic acid and derivatives 1,0881 N02BA01 Acetylsalicylic acid (O) 1339823,76 g 3 g 0,9301 N02BA80 Acetylsalicylic acid + Ascorbic acid (O) 227627,8 g 3 g 0,1580 N02BB 0,0028 N02BB02 sodium (O) 125 g 3 g 0,0001 N02BB02 Metamizole sodium (P) 1580 g 3 g 0,0011 N02BB02 Metamizole sodium (P, V) 2290 g 3 g 0,0016 N02BE Anilides 11,8319 N02BE01 Paracetamol (O) 10910083,1 g 3 g 7,5734 N02BE01 Paracetamol (P) 237192 g 3 g 0,1647 N02BE01 Paracetamol (R) 76384,7 g 3 g 0,0530 N02BE75 Paracetamol+ + Phenylephrine (O) 97775 g 3 g 0,0679 Paracetamol+ + + N02BE81 546424 g 3 g 0,3793 (O) N02BE83 Paracetamol+ (O) 65990 g 3 g 0,0458 N02BE84 Paracetamol+ Phenylephrine+ Ascorbic acid (O) 1247113,75 g 3 g 0,8657

30/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

N02BE85 Paracetamol+ + Ascorbic acid (O) 144004 g 3 g 0,1000 Paracetamol+ Phenylephrine+ hydrate+ Ascorbic acid+ N02BE86 427950 g 3 g 0,2971 Caffeine (O) N02BE87 Paracetamol+ Pseudoephedrine (O) 93785 g 3 g 0,0651 N02BE91 Paracetamol+ Ascorbic acid (O) 3267 g 3 g 0,0023 N02BE92 Paracetamol+ Codeine (O) 923550 g 3 g 0,6411 N02BE94 Paracetamol+ Codeine+ Caffeine (O) 1585224 g 3 g 1,1004 N02BE95 Paracetamol+ Phenylephrine (O) 70125 g 3 g 0,0487 N02BE97 Paracetamol+ Pseudoephedrine+ Dextromethorphan (O) 615594 g 3 g 0,4273 N02BE99 Paracetamol+ Dextromethorphan (O) 240 g 3 g 0,0002 N02BG Other analgesics and antipyretics 0,0420 N02BG07 (O) 8059 g 0,4 g 0,0420 N02C ANTIMIGRAINE PREPARATIONS 0,7012 N02CC Selective serotonin (5HT1) agonists 0,7012 N02CC01 Sumatriptan (N) 4,12 g 0,02 g 0,0004 N02CC01 Sumatriptan (O) 13812,9 g 0,05 g 0,5753 N02CC02 Naratriptan (O) 0,11 g 2,5 mg 0,0001 N02CC03 Zolmitriptan (O) 71,05 g 2,5 mg 0,0592 N02CC04 Rizatriptan (O) 55,62 g 0,01 g 0,0116 N02CC07 Frovatriptan (O) 65,5 g 2,5 mg 0,0546 N03 ANTIEPILEPTICS 8,5025 N03A ANTIEPILEPTICS 8,5025 N03AA Barbiturates and derivatives 0,4631 N03AA02 (O) 19390 g 0,1 g 0,4038 N03AA02 Phenobarbital (P) 70 g 0,1 g 0,0015 N03AA03 (O) 34725 g 1,25 g 0,0579 N03AA80 Benzobarbital (O) 5 g N03AB Hydantoin derivatives 0,0482 N03AB02 (O) 6730 g 0,3 g 0,0467 N03AB02 Phenytoin (P) 210 g 0,3 g 0,0015 N03AD derivatives 0,0112 N03AD01 (O) 6695 g 1,25 g 0,0112 N03AE derivatives 0,6476 N03AE01 Clonazepam (O) 2487,9 g 0,008 g 0,6476 N03AF Carboxamide derivatives 2,9831 N03AF01 (O) 1033851 g 1 g 2,1530 N03AF02 (O) 398625 g 1 g 0,8301 N03AG derivatives 1,4635 N03AG01 Valproic acid (O) 1049250 g 1,5 g 1,4567 N03AG01 Valproic acid (P) 643,3 g 1,5 g 0,0009 N03AG04 (O) 5700 g 2 g 0,0059 N03AX Other antiepileptics 2,8858 N03AX03 Sultiame (O) 740 g 0,4 g 0,0039 N03AX09 (O) 69607,44 g 0,3 g 0,4832 N03AX11 (O) 30633 g 0,3 g 0,2126 N03AX12 (O) 774810 g 1,8 g 0,8964 N03AX14 (O) 281827,5 g 1,5 g 0,3913 N03AX14 Levetiracetam (P) 25 g 1,5 g <0,0001 N03AX16 Pregabalin (O) 128287,95 g 0,3 g 0,8905 N03AX17 Stiripentol (O) 180 g 1 g 0,0004 N03AX21 (O) 2007,6 g 0,9 g 0,0046 N03AX22 (O) 10,752 g 8 mg 0,0028 N04 ANTI-PARKINSON DRUGS 3,8455 N04A AGENTS 0,6155 N04AA Tertiary amines 0,6155 N04AA01 (O) 2955,8 g 0,01 g 0,6155 N04B DOPAMINERGIC AGENTS 3,2300 N04BA Dopa and dopa derivatives 1,3934

31/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

N04BA03 Levodopa + Carbidopa+ Entacapone (O) 63160 g 0,45 g 0,2923 N04BA80 Levodopa + Benserazide (O) 241640 g 0,6 g 0,8387 N04BA81 Levodopa + Carbidopa (intestin) 7448 g N04BA81 Levodopa + Carbidopa (O) 75609,1 g 0,6 g 0,2624 N04BB derivatives 0,3352 N04BB01 (O) 32190 g 0,2 g 0,3352 N04BB01 Amantadine (P) 44 g N04BC Dopamine agonists 0,7139 N04BC04 (O) 962,864 g 0,006 g 0,3342 N04BC05 (O) 452,0213 g 2,5 mg 0,3765 N04BC07 (P) 30,3 g 20 mg 0,0032 N04BD Monoamine oxidase type B inhibitors 0,7875 N04BD02 Rasagiline (O) 378,166 g 0,001 g 0,7875 N05 43,5272 N05A 8,7117 N05AA with aliphatic side-chain 0,1748 N05AA01 (O) 14000 g 0,3 g 0,0972 N05AA01 Chlorpromazine (P) 90 g 0,1 g 0,0019 N05AA02 (O) 10881 g 0,3 g 0,0755 N05AA02 Levomepromazine (P, V) 10,75 g 0,1 g 0,0002 N05AB Phenothiazines with structure 0,1038 N05AB02 (P) 16,8 g 0,001 g 0,0350 N05AB03 (O) 476,8 g 0,03 g 0,0331 N05AB03 Perphenazine (P) 120,102 g 0,007 g 0,0357 N05AB04 (O) 3,78 g N05AC Phenothiazines with structure 0,0021 N05AC01 (O) 50,4 g 0,05 g 0,0021 N05AD derivatives 1,1075 N05AD01 (O) 2112,675 g 0,008 g 0,5500 N05AD01 Haloperidol (P) 838,1 g 0,008 g 0,2182 N05AD03 (O) 46302,5 g 0,3 g 0,3214 N05AD08 (P) 21,6 g 2,5 mg 0,0180 N05AE derivatives 0,1380 N05AE03 (O) 822,488 g 0,016 g 0,1071 N05AE04 (O) 1190,72 g 0,08 g 0,0310 N05AF derivatives 0,9148 N05AF01 (O) 361,8 g 0,006 g 0,1256 N05AF01 Flupentixol (P) 117,42 g 0,004 g 0,0611 N05AF03 (O) 31972,5 g 0,3 g 0,2219 N05AF05 (O) 1173 g 0,03 g 0,0814 N05AF05 Zuclopenthixol (P) 63 g 0,03 g 0,0044 N05AF05 Zuclopenthixol (P) 3027,6 g 0,015 g 0,4203 N05AG Diphenylbutylpiperidine derivatives <0,0001 N05AG02 Pimozide (O) 0,03 g 0,004 g <0,0001 N05AH Diazepines, oxazepines and thiazepines 4,6831 N05AH02 (O) 83458,75 g 0,3 g 0,5793 N05AH03 (O) 8847,44 g 0,01 g 1,8425 N05AH03 Olanzapine (P) 85,735 g 0,01 g 0,0179 N05AH04 (O) 430915 g 0,4 g 2,2435 N05AL 0,1435 N05AL01 (O) 23784 g 0,8 g 0,0619 N05AL05 (O) 15678 g 0,4 g 0,0816 N05AN 0,2002 N05AN01 Lithium (O) 86520 g 0,9 g 0,2002 N05AX Other antipsychotics 1,2438 N05AX08 (O) 1468,9 g 0,005 g 0,6118 N05AX08 Risperidone (P) 27,5875 g 2,7 mg 0,0213 N05AX12 (O) 3879,57 g 0,015 g 0,5386 N05AX12 Aripiprazole (P) 1,0725 g 0,015 g 0,0001

32/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

N05AX12 Aripiprazole (P) 144,4 g 0,0133 g 0,0226 N05AX13 (P) 59,225 g 2,5 mg 0,0493 N05B 14,0543 N05BA Benzodiazepine derivatives 14,0535 N05BA01 (O) 29669,7 g 0,01 g 6,1787 N05BA01 Diazepam (P) 638,1 g 0,01 g 0,1329 N05BA01 Diazepam (R) 66,75 g 0,01 g 0,0139 N05BA02 (O) 1,5 g 0,03 g 0,0001 N05BA03 (O) 1 g 0,02 g 0,0001 N05BA04 (O) 1122,9 g 0,05 g 0,0468 N05BA06 (O) 334,02 g 2,5 mg 0,2782 N05BA06 Lorazepam (P) 4 g 2,5 mg 0,0033 N05BA08 (O) 6571,845 g 0,01 g 1,3686 N05BA09 (O) 182 g 0,02 g 0,0190 N05BA12 (O) 2873,85 g 0,001 g 5,9848 N05BA80 (O) 13 g 0,001 g 0,0271 N05BB Diphenylmethane derivatives 0,0005 N05BB01 (O) 16,35 g 0,075 g 0,0005 N05BE Azaspirodecanedione derivatives 0,0004 N05BE01 (O) 6 g 0,03 g 0,0004 N05C HYPNOTICS AND SEDATIVES 20,7612 N05CD Benzodiazepine derivatives 0,8277 N05CD02 Nitrazepam (O) 1109,2 g 0,005 g 0,4620 N05CD05 Triazolam (O) 11 g 0,25 mg 0,0916 N05CD08 Midazolam (O) 1283,7638 g 0,015 g 0,1782 N05CD08 Midazolam (P) 690,2327 g 0,015 g 0,0958 N05CF Benzodiazepine related drugs 19,8781 N05CF01 Zopiclone (O) 57973,05 g 7,5 mg 16,0972 N05CF02 Zolpidem (O) 18155,55 g 0,01 g 3,7809 N05CH Melatonin receptor agonists 0,0504 N05CH01 Melatonin (O) 48,384 g 2 mg 0,0504 N05CM Other hypnotics and sedatives 0,0051 N05CM18 (P) 2,425 g 1 mg 0,0051 N06 PSYCHOANALEPTICS 32,0181 N06A ANTIDEPRESSANTS 27,2584 N06AA Non-selective monoamine reuptake inhibitors 2,0700 N06AA02 (O) 65 g 0,1 g 0,0014 N06AA04 (O) 3026,1 g 0,1 g 0,0630 N06AA09 (O) 57328,25 g 0,075 g 1,5918 N06AA10 (O) 14905 g 0,075 g 0,4139 N06AB Selective serotonin reuptake inhibitors 16,8494 N06AB03 (O) 28792,92 g 0,02 g 2,9981 N06AB04 (O) 14179,76 g 0,02 g 1,4765 N06AB05 (O) 22266,6 g 0,02 g 2,3185 N06AB06 (O) 86678,4 g 0,05 g 3,6102 N06AB08 (O) 291 g 0,1 g 0,0061 N06AB10 (O) 30925,02 g 0,01 g 6,4401 N06AF Monoamine oxidase inhibitors, non-selective 0,0069 N06AF03 (O) 15 g N06AF04 Tranylcypromine (O) 33 g 0,01 g 0,0069 N06AX Other antidepressants 8,3321 N06AX03 (O) 28,8 g 0,06 g 0,0010 N06AX11 (O) 24314,04 g 0,03 g 1,6878 N06AX12 Bupropione (O) 59553 g 0,3 g 0,4134 N06AX14 (O) 17997,75 g 0,0375 g 0,9995 N06AX16 (O) 115620,6 g 0,1 g 2,4078 N06AX17 (O) 11,2 g 0,1 g 0,0002 N06AX18 (O) 1,2 g 0,008 g 0,0003 N06AX21 (O) 49618,98 g 0,06 g 1,7222

33/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

N06AX22 Agomelatine (O) 10079,3 g 0,025 g 0,8396 N06AX26 (O) 1249,78 g 10 mg 0,2603 PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND N06B 0,9223 NOOTROPICS N06BA Centrally acting sympathomimetics 0,6238 N06BA04 (O) 7952,64 g 0,03 g 0,5520 N06BA07 Modafinil (O) 429 g 0,3 g 0,0030 N06BA09 (O) 2643,368 g 0,08 g 0,0688 N06BC derivatives 0,0002 N06BC80 Coffeini- (P) 35 g 0,4 g 0,0002 N06BC81 Caffeine citrate (O, P) 31 g N06BX Other psychostimulants and nootropics 0,2983 N06BX03 (O) 317112 g 2,4 g 0,2752 N06BX18 (O) 166,5 g 15 mg 0,0231 N06BX83 Aminobutyric acid (O) 11895 g N06D ANTI-DEMENTIA DRUGS 3,8374 N06DA Anticholinesterases 0,6660 N06DA02 Donepezil (O) 2398,62 g 7,5 mg 0,6660 N06DA04 (O) 0,224 g 0,016 g <0,0001 N06DX Other anti-dementia drugs 3,1714 N06DX01 (O) 1823,42 g 0,02 g 0,1899 N06DX02 Ginkgo folium (O) 171802,8 g 0,12 g 2,9815 N06DX80 cerebrolysine (P) 49,496 g N07 OTHER NERVOUS SYSTEM DRUGS 11,4289 N07A PARASYMPATHOMIMETICS 0,3547 N07AA Anticholinesterases 0,3547 N07AA01 (O) 29,1 g 0,06 g 0,0010 N07AA01 neostigmine (P) 33,27 g 0,002 g 0,0346 N07AA02 bromide (O) 25530 g 0,18 g 0,2954 N07AA03 bromide (O) 3,5 g 0,005 g 0,0015 N07AA80 Neostigmine+ (P) 10690 ml 1 ml 0,0223 N07B DRUGS USED IN ADDICTIVE DISORDERS 2,9478 N07BA Drugs used in dependence 1,2839 N07BA01 Nicotine (O) 11450,34 g 0,03 g 0,7948 N07BA01 Nicotine (TD) 3054,898 g 0,014 g 0,4544 N07BA03 (O) 33,278 g 2 mg 0,0347 N07BB Drugs used in dependence 0,2607 N07BB01 (O) 23530 g 0,2 g 0,2450 N07BB01 Disulfiram (P) 168 g N07BB03 (O) 111,888 g 2 g 0,0001 N07BB04 (O) 98 g 50 mg 0,0041 N07BB05 (O) 99,414 g 18 mg 0,0115 N07BC Drugs used in opioid dependence 1,4031 N07BC02 (O) 16630 g 0,025 g 1,3853 N07BC51 + Naloxone (SL) 68,6 g 8 mg 0,0179 N07C ANTIVERTIGO PREPARATIONS 8,1029 N07CA Antivertigo preparations 8,1029 N07CA01 (O) 76513,92 g 0,024 g 6,6392 N07CA02 (O) 63243,75 g 0,09 g 1,4634 N07CA03 (O) 1,8 g 0,01 g 0,0004 N07X OTHER NERVOUS SYSTEM DRUGS 0,0235 N07XX Other nervous system drugs 0,0235 N07XX02 (O) 921,2 g 0,1 g 0,0192 N07XX06 (O) 170,8 g 0,1 g 0,0036 N07XX07 Fampridine (O) 7,28 g 20 mg 0,0008 PRODUCTS, AND P 0,9476 REPELLENTS P01 0,7486

34/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL P01A DISEASES P01AB derivatives P01AB01 Metronidazole (O) 5119,2 g P01B ANTIMALARIALS 0,7486 P01BA Aminoquinolines 0,7274 P01BA02 (O) 180144 g 0,516 g 0,7270 P01BA03 (O) 2,4 g 0,015 g 0,0003 P01BB Biguanides 0,0196 P01BB51 + (O) 1032 pieces 16 pieces 0,0001 P01BB51 Proguanil+ Atovaquone (O) 37404 pieces 4 pieces 0,0195 P01BC Methanolquinolines 0,0014 P01BC01 (P) 49 g 1,5 g 0,0001 P01BC02 (O) 654 g 1 g 0,0014 P01BD Diaminopyrimidines 0,0002 P01BD01 (O) 7,5 g 0,075 g 0,0002 P02 0,1990 P02B ANTITREMATODALS 0,0003 P02BA derivatives and related substances 0,0003 P02BA01 (O) 403,2 g 3 g 0,0003 P02C ANTINEMATODAL AGENTS 0,1987 P02CA derivatives 0,1986 P02CA01 (O) 17973,6 g 0,2 g 0,1872 P02CA03 (O) 2200 g 0,4 g 0,0115 P02CF Avermectines 0,0001 P02CF01 (O) 0,54 g 12 mg 0,0001 , INCL. SCABICIDES, INSECTICIDES P03 AND REPELLENTS P03A ECTOPARASITICIDES, INCL. SCABICIDES P03AC Pyrethrines, incl. synthetic compounds P03AC04 (C) 6200 g P03AC81 Allethrin+ Piperonyl butoxid (C) 4000 g P03AX Other ectoparasiticides, incl. scabicides P03AX01 (C) 498750 g R 85,4760 R01 NASAL PREPARATIONS 34,6334 AND OTHER NASAL PREPARATIONS R01A 32,1519 FOR TOPICAL USE R01AA Sympathomimetics, plain 22,0982 R01AA05 (N) 365,7975 g 0,4 mg 1,9044 R01AA07 (N) 7757,495 g 0,8 mg 20,1937 R01AB Sympathomimetics, combinations excl. corticosteroids 1,6659 R01AB83 Xylometazoline+ (N) 232670 ml 0,8 ml 0,6057 R01AB85 Xylometazoline+ Dexpanthenol (N) 407310 ml 0,8 ml 1,0603 R01AC Antiallergic agents, excl. corticosteroids 0,2882 R01AC03 (N) 77,5 g 0,56 mg 0,2882 R01AD Corticosteroids 8,0996 R01AD01 (N) 18,55 g 0,4 mg 0,0966 R01AD05 Budesonide (N) 85,778 g 0,2 mg 0,8932 R01AD08 Fluticasone (N) 73,212 g 0,2 mg 0,7623 R01AD09 Mometasone (N) 301,742 g 0,2 mg 3,1419 R01AD12 (N) 150,3348 g 0,11 mg 2,8461 R01AD81 Fluticasone+ Azelastine (N) 690600 doses 4 doses 0,3595 R01AX Other nasal preparations R01AX06 (N) 30 g R01AX83 + Tocopherol (N) 164600 ml Tocopherol+ Eucalyptus oil+ Pine silvesteris oil+ Thymol+ R01AX87 187660 ml Peppermint oil+ Guaiazulene (N)

35/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

R01B NASAL DECONGESTANTS FOR SYSTEMIC USE 2,4815 R01BA Sympathomimetics 2,4815 R01BA02 Pseudoephedrine (O) 161540,76 g 0,24 g 1,4017 R01BA81 Pseudoephedrine+ (O) 29386,68 g 0,24 g 0,2550 R01BA84 Pseudoephedrine+ Guaifenesin (O) 12430,8 g 0,24 g 0,1079 R01BA89 Pseudoephedrine+ (O) 16319,52 g 0,24 g 0,1416 R01BA93 Pseudoephedrine+ (O) 66307,92 g 0,24 g 0,5754 R02 THROAT PREPARATIONS 2,4667 R02A THROAT PREPARATIONS 2,4667 R02AA Antiseptics 2,0158 R02AA06 (O) 188658 pieces R02AA82 + Cetylpyridinium chloride (O) 683840 pieces 6 pieces 0,2373 R02AA82 Benzydamine+ Cetylpyridinium chloride (O) 824070 ml R02AA89 Povidone, iodinated+ Allantoin (O) 346560 ml R02AA92 + Cinchocaine (O) 1226320 pieces 6 pieces 0,4256 R02AA94 + Dichlorobenzyl alcohol (O) 697320 pieces 6 pieces 0,2420 R02AA95 Amylmetacresol+ Dichlorobenzyl alcohol+ Levomenthol (O) 1994016 pieces 6 pieces 0,6921

R02AA96 Amylmetacresol+ Dichlorobenzyl alcohol+ Ascorbic acid (O) 461352 pieces 6 pieces 0,1601 R02AA98 Cetylpyridinium chloride+ Benzocaine (O) 418770 ml R02AA98 Cetylpyridinium chloride+ Benzocaine (O) 646164 pieces 6 pieces 0,2243 Benzalkonium chloride+ Eucalyptus oil+ Levomenthol+ R02AA99 98940 pieces 6 pieces 0,0343 Peppermint oil+ Thymol (O) R02AB Antibiotics R02AB03 (N, O) 57490 ml R02AD Anesthetics, local 0,2243 R02AD80 Lidocaine+ Propyl parahydroxybenzoate (O) 646300 pieces 6 pieces 0,2243 R02AX Other throat preparations 0,2265 R02AX01 (O) 4786,46 g 44 mg 0,2265 R02AX80 Thyme herb+ Sage leaf (O) 47115 ml R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES 25,1571 R03A ADRENERGICS, INHALANTS 17,1419 R03AC Selective beta-2-adrenoceptor agonists 4,9490 R03AC02 (I) 999,396 g 0,8 mg 2,6016 R03AC02 Salbutamol (I) 1678 g 0,01 g 0,3494 R03AC03 (I) 0,05 g 0,002 g 0,0001 R03AC04 (I) 83,24 g 0,6 mg 0,2889 R03AC12 (I) 7,887 g 0,1 mg 0,1642 R03AC13 (I) 10,3197 g 0,024 mg 0,8954 R03AC18 (I) 46,773 g 0,15 mg 0,6494 Adrenergics in combination with corticosteroids or other drugs, R03AK 10,2647 excl. anticholinergics R03AK06 Salmeterol+ Fluticasone (I) 829680 doses 4 doses 0,4320 R03AK06 Salmeterol+ Fluticasone (I) 3246960 doses 2 doses 3,3809 R03AK07 Formoterol+ Budesonide (I) 1024800 doses 2 doses 1,0671 R03AK07 Formoterol+ Budesonide (I) 5522400 doses 4 doses 2,8751 R03AK08 Formoterol+ Beclometasone (I) 1677960 doses 4 doses 0,8736 R03AK10 + Fluticasone furoate (I) 785640 doses 1 doses 1,6361 R03AL adrenergics in combination with anticholinergics 1,9282 R03AL01 Fenoterol+ Ipratropium bromide (I) 132660 ml 16 ml 0,0173 R03AL01 Fenoterol+ Ipratropium bromide (I) 2201800 doses 6 doses 0,7642 R03AL03 Vilanterol+ (I) 118950 doses 1 doses 0,2477 R03AL04 Indacaterol+ Glycopyrronium bromide (I) 243510 doses 1 doses 0,5071 R03AL05 Formoterol+ (I) 205980 doses 2 doses 0,2145 R03AL06 + (I) 170400 doses 2 doses 0,1774 OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, R03B 4,9496 INHALANTS

36/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

R03BA Glucocorticoids 1,7343 R03BA01 Beclometasone (I) 0,15 g 1,5 mg 0,0002 R03BA01 Beclometasone (I) 1,45 g 0,8 mg 0,0038 R03BA02 Budesonide (I) 132,6 g 1,5 mg 0,1841 R03BA02 Budesonide (I) 369,688 g 0,8 mg 0,9623 R03BA05 Fluticasone (I) 168,225 g 0,6 mg 0,5839 R03BB Anticholinergics 3,2153 R03BB01 Ipratropium bromide (I) 26,265 g 0,3 mg 0,1823 R03BB01 Ipratropium bromide (I) 31,44 g 0,12 mg 0,5456 R03BB04 Tiotropium bromide (I) 3,1361 g 0,005 mg 1,3062 R03BB05 Aclidinium bromide (I) 133,9456 g 0,644 mg 0,4331 R03BB06 Glycopyrronium bromide (I) 15,8054 g 44 mcg 0,7481 R03C ADRENERGICS FOR SYSTEMIC USE 0,1879 R03CC Selective beta-2-adrenoceptor agonists 0,1879 R03CC02 Salbutamol (O) 1081,5 g 0,012 g 0,1877 R03CC02 Salbutamol (P) 0,147 g 0,012 g <0,0001 R03CC03 Terbutaline (O) 1,2 g 0,015 g 0,0002 OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY R03D 2,8777 DISEASES R03DA 1,4522 R03DA04 (O) 273640 g 0,4 g 1,4246 R03DA05 (P) 7937,6 g 0,6 g 0,0276 R03DC receptor antagonists 1,4017 R03DC03 (O) 6730,724 g 0,01 g 1,4017 R03DX Other systemic drugs for obstructive airway diseases 0,0238 R03DX05 (P) 182,85 g 0,016 g 0,0238 R05 COUGH AND COLD PREPARATIONS 7,9012 EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH R05C 7,7458 SUPPRESSANTS R05CA Expectorants 0,1681 R05CA03 Guaifenesin (O) 72660 g 0,9 g 0,1681 R05CA12 Hederae helicis folium (O) 109510 pieces R05CA12 Hederae helicis folium (O) 8180895 ml R05CA86 Iceland moss (O) 6015150 ml Distillate of rectified essential oils of eucalyptus, sweet orange, R05CA87 1309080 pieces myrtle and lemon (O) R05CA88 Thyme herb+ nõmm-liivatee+ teeleht (O) 977900 ml R05CA89 Thyme herb+ Hederae helicis folium (O) 153900 ml R05CA91 Thyme herb+ Marshmallow root (O) 4707900 ml R05CA92 Thyme herb (O) 233940 pieces R05CB Mucolytics 7,5777 R05CB01 (O) 1037359,2 g 0,5 g 4,3206 R05CB01 Acetylcysteine (P) 7275 g R05CB02 (O) 7817,92 g 0,024 g 0,6784 R05CB03 (O) 203197,5 g 1,5 g 0,2821 R05CB06 (O) 131421,75 g 0,12 g 2,2807 R05CB13 (I) 19,125 g 2,5 mg 0,0159 COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH R05D 0,1015 EXPECTORANTS R05DB Other cough suppressants 0,1015 R05DB09 (O) 3899,5 g 0,08 g 0,1015 COUGH SUPPRESSANTS AND EXPECTORANTS, R05F 0,0539 COMBINATIONS R05FA Opium derivatives and expectorants 0,0539 R05FA80 Codeine+ Guaifenesin (O) 776100 ml 30 ml 0,0539 R05X OTHER COLDPREPARATIONS R05XA Other cold combination preparations

37/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

Gentian root+ nurmenukuõis+ hapu oblikas+ Elder flower+ R05XA80 3923,6 g raudürdiürt (O) Gentian root+ nurmenukuõis+ hapu oblikas+ Elder flower+ R05XA80 1987540 pieces raudürdiürt (O) R06 FOR SYSTEMIC USE 15,3171 R06A ANTIHISTAMINES FOR SYSTEMIC USE 15,3171 R06AA Aminoalkyl ethers 0,4967 R06AA02 (O) 74,5 g 0,2 g 0,0008 R06AA02 Diphenhydramine (P) 26,5 g R06AA04 (O) 422,64 g 0,002 g 0,4401 R06AA04 Clemastine (P) 53,65 g 0,002 g 0,0559 R06AE Piperazine derivatives 6,9086 R06AE07 Cetirizine (O) 31151,25 g 0,01 g 6,4872 R06AE09 (O) 1011,68 g 0,005 g 0,4214 R06AX Other antihistamines for systemic use 7,9117 R06AX13 Loratadine (O) 18711,5 g 0,01 g 3,8967 R06AX15 (O) 40 g 0,2 g 0,0004 R06AX17 (O) 2,4 g 0,002 g 0,0025 R06AX22 (O) 6569,9 g 0,01 g 1,3682 R06AX27 (O) 3971,47 g 0,005 g 1,6541 R06AX28 (O) 767,64 g 0,01 g 0,1599 R06AX29 (O) 7971,2 g 20 mg 0,8300 R07 OTHER RESPIRATORY SYSTEM PRODUCTS 0,0005 R07A OTHER RESPIRATORY SYSTEM PRODUCTS 0,0005 R07AA 0,0005 R07AA81 Porcine lung phospholipids (endotrach) 35,28 g 0,16 g 0,0005 S SENSORY ORGANS 29,1318 S01 OPHTHALMOLOGICALS 29,1318 S01A ANTIINFECTIVES S01AA Antibiotics S01AA01 Chloramphenicol (S) 188280 ml S01AA12 Tobramycin (S) 46710 ml S01AA12 Tobramycin (S) 52223,5 g S01AA13 Fusidic acid (S) 45405 g S01AD Antivirals S01AD03 Aciclovir (S) 2898 g S01AE Fluoroquinolones S01AE03 Ciprofloxacin (S) 18530 ml S01AE05 Levofloxacin (S) 22905 ml S01AE07 Moxifloxacin (S) 13525 ml S01AX Other antiinfectives S01AX15 (S) 80 ml S01B ANTIINFLAMMATORY AGENTS S01BA Corticosteroids, plain S01BA01 Dexamethasone (S) 120 pieces S01BA01 Dexamethasone (S) 7899,5 g S01BA01 Dexamethasone (S) 125905 ml S01BA02 Hydrocortisone (S) 6414 g S01BA14 (S) 3140 ml S01BC Antiinflammatory agents, non-steroids S01BC05 Ketorolac (S) 5000 ml S01BC10 (S) 23805 ml ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN S01C COMBINATION S01CA Corticosteroids and antiinfectives in combination S01CA80 Dexamethasone+ Neomycin+ (S) 47675 ml S01CA81 Dexamethasone+ Tobramycin (S) 13972 g S01CA81 Dexamethasone+ Tobramycin (S) 38160 ml S01CA82 Dexamethasone+ Chloramphenicol (S) 39119,5 g

38/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

S01CA82 Dexamethasone+ Chloramphenicol (S) 417030 ml S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS 29,1318 S01EA Sympathomimetics in therapy 0,0008 S01EA05 Brimonidine (S) 80 ml 0,2 ml 0,0008 S01EB Parasympathomimetics 0,0197 S01EB01 hydrochloride (S) 2970 ml 0,4 ml 0,0155 S01EB02 (S) 810 ml 0,4 ml 0,0042 S01EC Carbonic anhydrase inhibitors 3,0376 S01EC01 (O) 21315 g 0,75 g 0,0592 S01EC01 Acetazolamide (P) 68 g 0,75 g 0,0002 S01EC03 (S) 117925 ml 0,3 ml 0,8186 S01EC04 (S) 143625 ml 0,2 ml 1,4955 S01EC80 Brinzolamide+ Brimonidine (S) 63780 ml 0,2 ml 0,6641 S01ED Beta blocking agents 17,2087 S01ED01 (S) 130025 g 40 mg 6,7694 S01ED01 Timolol (S) 178420 ml 0,2 ml 1,8578 S01ED02 (S) 95765 ml 0,2 ml 0,9972 S01ED80 Timolol+ Dorzolamide (S) 301010 ml 0,2 ml 3,1343 S01ED81 Timolol+ (S) 46227,5 ml 0,2 ml 0,4813 S01ED82 Timolol+ (S) 97707 ml 0,2 ml 1,0174 S01ED83 Timolol+ Brinzolamide (S) 220835 ml 0,2 ml 2,2994 S01ED84 Timolol+ (S) 60427,5 ml 0,2 ml 0,6292 S01ED85 Timolol+ (S) 2106,6 ml 0,2 ml 0,0219 S01ED86 Timolol+ Brimonidine (S) 75 ml 0,2 ml 0,0008 S01EE analogues 8,8650 S01EE01 Latanoprost (S) 268455 ml 0,1 ml 5,5906 S01EE03 Bimatoprost (S) 129 ml 0,1 ml 0,0027 S01EE04 Travoprost (S) 102507,5 ml 0,1 ml 2,1347 S01EE05 Tafluprost (S) 163800 ml 0,3 ml 1,1370 S01F MYDRIATICS AND CYCLOPLEGICS S01FA Anticholinergics S01FA01 Atropine (S) 270 ml S01FA04 (S) 34005 ml S01FA06 (S) 15195 ml S01FB Sympathomimetics excl. antiglaucoma preparations S01FB01 Phenylephrine (S) 6760 ml S01G DECONGESTANTS AND ANTIALLERGICS S01GA Sympathomimetics used as decongestants S01GA02 (S) 331260 ml S01GX Other antiallergics S01GX01 (S) 104590 ml S01GX07 Azelastine (S) 23622 ml S01GX09 (S) 16690 ml S01H LOCAL ANESTHETICS S01HA Local anesthetics S01HA03 (S) 10460 ml S01HA04 (S) 38160 ml S01J DIAGNOSTIC AGENTS S01JA Colouring agents S01JA01 Fluorescein (P) 5680 ml S01JA01 Fluorescein (S) 3020 ml S01JA81 Fluorescein+ + Chlorobutanol (S) 1470 ml S01K SURGICAL AIDS S01KA Viscoelastic substances S01KA02 Hypromellose (S) 3120 g S01L OCULAR VASCULAR DISORDER AGENTS S01LA Antineovascularisation agents S01LA04 (S) 12 pieces S01LA05 (S) 146 pieces

39/41 Estonian Statistics on Medicines 2016

ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

S01X OTHER OPHTHALMOLOGICALS S01XA Other ophthalmologicals S01XA03 Sodium chloride (S) 336 g S01XA18 Ciclosporin (S) 288 ml S01XA80 Retinol+ Dexpanthenol (S) 7035 g S01XA81 Carbomer (S) 210320 g S01XA82 Hypromellose (S) 126600 ml S01XA85 Hypromellose+ Dextran (S) 484575 ml S02 OTOLOGICALS CORTICOSTEROIDS AND ANTIINFECTIVES IN S02C COMBINATION S02CA Corticosteroids and antiinfectives in combination S02CA81 Dexamethasone+ Neomycin+ Acetic acid, glacial (A) 1330 ml S02CA82 Hydrocortisone+ Ciprofloxacin (A) 130760 ml T HERBAL MEDICINAL PRODUCTS T01 HERBAL MEDICINAL PRODUCTS T01R HERBAL MEDICINAL PRODUCTS T01RS Herbal medicinal products T01RS01 herbal preparation (O) 643890 pieces T01RS01 herbal preparation (O) 13838490 ml T01RS02 homeopathic preparations (A) 3130 ml T01RS02 homeopathic preparations (C) 600750 g T01RS02 homeopathic preparations (N) 160 ml T01RS02 homeopathic preparations (O) 4610 g T01RS02 homeopathic preparations (O) 1368300 pieces T01RS02 homeopathic preparations (O) 2138750 ml T01RS02 homeopathic preparations (P) 220 ml V VARIOUS 0,1575 V01 V01A ALLERGENS V01AA extracts V01AA02 Grass pollen (O) 167 pieces V01AA02 Grass pollen (P) 99 pieces V01AA03 House dust mites (O) 147 pieces V01AA03 House dust mites (P) 24 ml V01AA03 House dust mites (P) 102 pieces V01AA05 Tree pollen (P) 248 pieces V01AA05 Tree pollen (SL) 548 pieces V01AA07 Allergen products (insects) (P) 216 pieces V01AA10 Flowers (O) 7 pieces V01AA11 Animals (O) 1 pieces V01AA80 Tree and grass pollen (O) 83 pieces V01AA80 Tree and grass pollen (P) 11 pieces V01AA83 Grass pollen+ Flowers (O) 11 pieces V01AA84 Tree and flower pollen (O) 32 pieces V03 ALL OTHER THERAPEUTIC PRODUCTS 0,1575 V03A ALL OTHER THERAPEUTIC PRODUCTS 0,1575 V03AB V03AB14 (P) 272,5 g V03AB15 Naloxone (P) 3,894 g V03AB16 (P) 24300 ml V03AB17 Methylthioninium chloride (P) 171,5 g V03AB24 Digitalis antitoxin (P) 1,44 g V03AB25 Flumazenil (P) 0,145 g V03AB33 Hydroxocobalamin (P) 65 g V03AB34 Fomepizole (P) 29 g V03AB35 (P) 40 g V03AB37 (P) 15 g V03AC Iron chelating agents

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ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day

V03AC01 (P) 1 g V03AC03 (O) 6062 g V03AE Drugs for treatment of and hyperphosphatemia 0,1001 V03AE01 sulfonate (O, R) 1173438,5 g 45 g 0,0543 V03AE02 Sevelamer (O) 85104 g 6,4 g 0,0277 V03AE03 Lanthan (O) 19507,5 g 2,25 g 0,0181 V03AF Detoxifying agents for antineoplastic treatment 0,0574 V03AF01 (P) 5382 g V03AF03 Calcium folinate (O) 24,3 g 0,06 g 0,0008 V03AF07 Rasburicase (P) 0,2925 g 0,014 g <0,0001 V03AF10 Sodium levofolinate (P) 814,5 g 0,03 g 0,0565 V03AN Medical gases V03AN01 (I) 449570000 ml V03AN05 Air, medicinal (I) 1540000 ml V04 DIAGNOSTIC AGENTS V04C OTHER DIAGNOSTIC AGENTS V04CD Tests for pituitary function V04CD04 Corticorelin (P) 0,0002 g V04CF Tuberculosis diagnostics V04CF01 (P) 26230 U V04CX Other diagnostic agents V04CX81 chloride (I) 98,412 g V04CX82 Hexaminolevulinate (P) 24,905 g V04CX83 Indocyanine green (P) 1,025 g V04CX85 Edrophonium chloride (P) 0,3 g V07 ALL OTHER NON-THERAPEUTIC PRODUCTS V07A ALL OTHER NON-THERAPEUTIC PRODUCTS V07AB Solvents and diluting agents, incl. irrigating solutions V07AB80 Sodium chloride (P) 6368800 ml V07AB83 for injection (NA) 7666400 ml V07AY Other non-therapeutic auxiliary products V07AY80 doonororgani säilituslahus (NA) 50400 ml V08 CONTRAST MEDIA V08A X-RAY CONTRAST MEDIA, IODINATED V08AA Watersoluble, nephrotropic, high osmolar X-ray contrast media V08AA01 Sodium amidotrizoate+ Meglumine Amidotrizoate (P) 11000 ml V08AB Watersoluble, nephrotropic, low osmolar X-ray contrast media V08AB02 (P) 1399794,5 g V08AB04 (P) 232475,4 g V08AB05 (P) 971724 g V08AB09 (P) 2629332 g V08AD Non-watersoluble X-ray contrast media V08AD01 Ethyl esters of iodised fatty acids (P) 38,4 g V08B X-RAY CONTRAST MEDIA, NON-IODINATED V08BA sulfate containing X-ray contrast media V08BA01 (O) 264720 g V08BA01 Barium sulfate (O, R) 72000 g V08C MAGNETIC RESONANCE IMAGING CONTRAST MEDIA V08CA Paramagnetic contrast media V08CA01 (P) 5750 ml V08CA03 (P) 70350 ml V08CA09 (P) 47242,5 ml V08CA10 (P) 3430 ml V08D ULTRASOUND CONTRAST MEDIA V08DA Ultrasound contrast media V08DA05 Sulphur hexafluoride (P) 35 ml

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