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Estonian Statistics on Medicines 2016 ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A ALIMENTARY TRACT AND METABOLISM 167,8985 A01 STOMATOLOGICAL PREPARATIONS 0,0738 A01A STOMATOLOGICAL PREPARATIONS 0,0738 A01AB Antiinfectives and antiseptics for local oral treatment 0,0738 A01AB09 Miconazole (O) 7088 g 0,2 g 0,0738 A01AB12 Hexetidine (O) 1951200 ml A01AB81 Neomycin+ Benzocaine (dental) 30200 pieces A01AB82 Demeclocycline+ Triamcinolone (dental) 680 g A01AC Corticosteroids for local oral treatment A01AC81 Dexamethasone+ Thymol (dental) 3094 ml A01AD Other agents for local oral treatment A01AD80 Lidocaine+ Cetylpyridinium chloride (gingival) 227150 g A01AD81 Lidocaine+ Cetrimide (O) 30900 g A01AD82 Choline salicylate (O) 864720 pieces A01AD83 Lidocaine+ Chamomille extract (O) 370080 g A01AD90 Lidocaine+ Paraformaldehyde (dental) 405 g A02 DRUGS FOR ACID RELATED DISORDERS 47,1312 A02A ANTACIDS 1,0133 Combinations and complexes of aluminium, calcium and A02AD 1,0133 magnesium compounds A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 811120 pieces 10 pieces 0,1689 A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 3101974 ml 50 ml 0,1292 A02AD83 Calcium carbonate+ Magnesium carbonate (O) 3434232 pieces 10 pieces 0,7152 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 46,1179 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 2,3855 A02BA02 Ranitidine (O) 340327,5 g 0,3 g 2,3624 A02BA02 Ranitidine (P) 3318,25 g 0,3 g 0,0230 A02BC Proton pump inhibitors 43,7324 A02BC01 Omeprazole (O) 263238,18 g 0,02 g 27,4097 A02BC02 Pantoprazole (O) 172288,06 g 0,04 g 8,9697 A02BC02 Pantoprazole (P) 356,4 g 0,04 g 0,0186 A02BC03 Lansoprazole (O) 9,87 g 0,03 g 0,0007 A02BC05 Esomeprazole (O) 102877,88 g 0,03 g 7,1414 A02BC05 Esomeprazole (P) 2770 g 0,03 g 0,1923 A02BD Combinations for eradication of Helicobacter pylori <0,0001 A02BD08 Bismuth subcitrate+ Tetracycline+ Metronidazole (O) 240 pieces 12 pieces <0,0001 DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03 7,9186 DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03A 6,9014 DISORDERS A03AA Synthetic anticholinergics, esters with tertiary amino group 0,9452 A03AA04 Mebeverine (O) 136170 g 0,3 g 0,9452 A03AB Synthetic anticholinergics, quaternary ammonium compounds <0,0001 A03AB02 Glycopyrronium bromide (P) 0,02 g 3 mg <0,0001 A03AD Papaverine and derivatives 4,4043 A03AD01 Papaverine hydrochloride (P) 65,8 g 0,1 g 0,0014 A03AD02 Drotaverine (O) 206916,32 g 0,1 g 4,3090 A03AD02 Drotaverine (P) 4507 g 0,1 g 0,0939 A03AX Other drugs for functional gastrointestinal disorders 1,5519 A03AX13 Simeticone (O) 372600,6965 g 0,5 g 1,5519 A03B BELLADONNA AND DERIVATIVES, PLAIN 0,1142 A03BA Belladonna alkaloids, tertiary amines 0,0971 A03BA01 Atropine (O, P) 25,39 g 0,0015 g 0,0352 A03BA01 Atropine (P) 44,53 g 0,0015 g 0,0618 1/41 Estonian Statistics on Medicines 2016 ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day Belladonna alkaloids, semisynthetic, quaternary ammonium A03BB 0,0171 compounds A03BB01 Butylscopolamine (O) 58,4 g 0,06 g 0,0020 A03BB01 Butylscopolamine (P) 430,5 g 0,06 g 0,0149 A03BB01 Butylscopolamine (R) 4,8 g 0,06 g 0,0002 A03F PROPULSIVES 0,9030 A03FA Propulsives 0,9030 A03FA01 Metoclopramide (O) 10519 g 0,03 g 0,7302 A03FA01 Metoclopramide (P) 1899,3 g 0,03 g 0,1318 A03FA01 Metoclopramide (R) 0,5 g 0,03 g <0,0001 A03FA03 Domperidone (O) 589,8 g 0,03 g 0,0409 A04 ANTIEMETICS AND ANTINAUSEANTS 0,1264 A04A ANTIEMETICS AND ANTINAUSEANTS 0,1264 A04AA Serotonin (5-HT3) antagonists 0,1117 A04AA01 Ondansetron (P) 29,62 g 0,016 g 0,0039 A04AA02 Granisetron (O) 60,64 g 0,002 g 0,0631 A04AA02 Granisetron (P) 64,4 g 0,003 g 0,0447 A04AD Other antiemetics 0,0147 A04AD01 Scopolamine (TD) 15 pieces 1 pieces <0,0001 A04AD12 Aprepitant (O) 395,865 g 0,095 g 0,0087 A04AD81 Fosaprepitant (P) 274,65 g 0,095 g 0,0060 A05 BILE AND LIVER THERAPY 2,4278 A05A BILE THERAPY 0,4881 A05AA Bile acid preparations 0,4881 A05AA02 Ursodeoxycholic acid (O) 175775 g 0,75 g 0,4881 A05B LIVER THERAPY, LIPOTROPICS 1,9397 A05BA Liver therapy 1,9397 A05BA03 Silymarin (O) 2963650 pieces A05BA80 Essential phospholipids (O) 2794350 pieces 3 pieces 1,9397 A05BA80 Essential phospholipids (P) 1865 pieces A06 DRUGS FOR CONSTIPATION 15,1259 A06A DRUGS FOR CONSTIPATION 15,1259 A06AB Contact laxatives 7,1290 A06AB02 Bisacodyl (O) 14645 g 0,01 g 3,0498 A06AB02 Bisacodyl (R) 875,6 g 0,01 g 0,1823 A06AB06 Senna glycosides (O) 10300 pieces 1 pieces 0,0214 A06AB08 Sodium picosulfate (O) 9304,062 g 0,005 g 3,8751 A06AB80 Sodium picosulfate+ Magnesium oxide+ Citric acid (O) 186 pieces 2 pieces 0,0002 A06AD Osmotically acting laxatives 7,1545 A06AD11 Lactulose (O) 21946884,8 g 6,7 g 6,8216 A06AD15 Macrogol (O) 1598600 g 10 g 0,3329 Macrogol+ Sodium citrate+ Citric acid+ Sodium chloride+ A06AD80 35000 ml Potassium chloride (O) Sodium sulphate, anhydrous+ Potassium chloride+ Sodium A06AD81 53092 pieces chloride+ Macrogol+ Sodium hydrogen carbonate (O) Macrogol+ Sodium sulphate, anhydrous+ Sodium chloride+ A06AD83 1 pieces Potassium chloride+ Ascorbic acid+ Sodium ascorbate (O) Sodium sulphate, anhydrous+ magnesium sulfate A06AD85 1102112 ml heptahydrate+ Potassium sulphate (O) A06AG Enemas 0,8425 A06AG11 Laurilsulfate, incl. combinations+ Sorbitol+ Sodium citrate (R) 404564 pieces 1 pieces 0,8425 A06AH Peripheral opioid receptor antagonists A06AH03 Naloxegol (O) 8,25 g A06AX Other drugs for constipation A06AX01 Glycerol (R) 300 pieces 2/41 Estonian Statistics on Medicines 2016 ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day Sodium hydrogen carbonate+ Sodium dihydrogen phosphate A06AX80 100 pieces (R) ANTIDIARRHEALS, INTESTINAL A07 3,8855 ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A07A INTESTINAL ANTIINFECTIVES <0,0001 A07AA Antibiotics <0,0001 A07AA11 Rifaximin (O) 7,2 g 0,6 g <0,0001 A07B INTESTINAL ADSORBENTS 0,4636 A07BC Other intestinal adsorbents 0,4636 A07BC05 Diosmectidum (O) 2003400 g 9 g 0,4636 A07C ELECTROLYTES WITH CARBOHYDRATES A07CA Oral rehydration salt formulations Sodium chloride+ Potassium chloride+ Sodium citrate+ A07CA80 60780 pieces Glucose (O) A07D ANTIPROPULSIVES 0,9245 A07DA Antipropulsives 0,9245 A07DA03 Loperamide (O) 4439,5 g 0,01 g 0,9245 A07E INTESTINAL ANTIINFLAMMATORY AGENTS 1,9117 A07EA Corticosteroids acting locally 0,0003 A07EA06 Budesonide (O) 1,2 g 0,009 g 0,0003 A07EA06 Budesonide (R) 1,6177 g A07EC Aminosalicylic acid and similar agents 1,9114 A07EC01 Sulfasalazine (O) 783050 g 2 g 0,8154 A07EC02 Mesalazine (O) 722900 g 1,5 g 1,0036 A07EC02 Mesalazine (R) 66584 g 1,5 g 0,0924 A07F ANTIDIARRHEAL MICROORGANISMS 0,5857 A07FA Antidiarrheal microorganisms 0,5857 A07FA02 Saccharomyces boulardii (O) 281237,5 g 1 g 0,5857 A07X OTHER ANTIDIARRHEALS A07XA Other antidiarrheals A07XA04 Racecadotril (O) 2681,92 g A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0171 A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0171 A08AB Peripherally acting antiobesity products 0,0171 A08AB01 Orlistat (O) 2958,48 g 0,36 g 0,0171 A09 DIGESTIVES, INCL. ENZYMES 1,4609 A09A DIGESTIVES, INCL. ENZYMES 1,4609 A09AA Enzyme preparations 1,4603 A09AA02 Lipase+ Amylase+ Protease (O) 2804925 pieces 4 pieces 1,4603 A09AC Enzyme and acid preparations, combinations 0,0006 A09AC80 Pepsin+ Betaine (O) 800 pieces 3 pieces 0,0006 A10 DRUGS USED IN DIABETES 61,5309 A10A INSULINS AND ANALOGUES 16,5197 A10AB Insulins and analogues for injection, fast-acting 6,2793 A10AB01 Insulin (human) (P) 900000 U 40 U 0,0469 A10AB04 Insulin lispro (P) 24964500 U 40 U 1,2997 A10AB05 Insulin aspart (P) 81061500 U 40 U 4,2203 A10AB06 Insulin glulisine (P) 13684500 U 40 U 0,7124 A10AC Insulins and analogues for injection, intermediate-acting 0,1243 A10AC01 Insulin (human) (P) 2388000 U 40 U 0,1243 Insulins and analogues for injection, intermediate- or long- A10AD 1,4836 acting combined with fast-acting A10AD04 Insulin lispro (P) 10512000 U 40 U 0,5473 A10AD05 Insulin aspart (P) 17985000 U 40 U 0,9363 A10AE Insulins and analogues for injection, long-acting 8,6325 A10AE04 Insulin glargine (P) 94092000 U 40 U 4,8987 3/41 Estonian Statistics on Medicines 2016 ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A10AE05 Insulin detemir (P) 71718000 U 40 U 3,7338 A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS 45,0111 A10BA Biguanides 19,7828 A10BA02 Metformin (O) 18999126 g 2 g 19,7828 A10BB Sulfonylureas 15,4082 A10BB07 Glipizide (O) 1414,95 g 0,01 g 0,2947 A10BB09 Gliclazide (O) 248991 g 0,06 g 8,6421 A10BB12 Glimepiride (O) 6215,1 g 0,002 g 6,4715 A10BD Combinations of oral blood glucose lowering drugs 4,2250 A10BD07 Metformin+ Sitagliptin (O) 1863400 pieces 2 pieces 1,9403 A10BD08 Metformin+ Vildagliptin (O) 803160 pieces 2 pieces 0,8363 A10BD10 Metformin+ Saxagliptin (O) 308580 pieces 2 pieces 0,3213 A10BD11 Metformin+ Linagliptin (O) 659940 pieces 2 pieces 0,6872 A10BD15 Metformin+ Dapagliflozin (O) 150528 pieces 2 pieces 0,1567 A10BD20 Metformin+ Empagliflozin (O) 272040 pieces 2 pieces 0,2833 A10BF Alpha glucosidase inhibitors 0,0001 A10BF01 Acarbose (O) 21 g 0,3 g 0,0001 A10BG Thiazolidinediones 0,0883 A10BG03 Pioglitazone (O) 1271,34 g 0,03 g 0,0883 A10BH Dipeptyl peptidase 4 (DPP-4) inhibitors 3,2135 A10BH01 Sitagliptin (O) 72375,1 g 0,1 g 1,5072 A10BH02 Vildagliptin (O) 7788 g 0,1 g 0,1622 A10BH03 Saxagliptin (O) 522,9 g 5 mg 0,2178 A10BH04 Alogliptin (O) 32,2 g 25 mg 0,0027 A10BH05 Linagliptin (O) 3178,05 g 5 mg 1,3237 A10BX Other blood glucose lowering drugs, excl.
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    Management of Common Skin Conditions In General Practice including the “red rash made easy” © Arroll, Fishman & Oakley, Department of General Practice and Primary Health Care University of Auckland, Tamaki Campus Reviewed by Hon A/Prof Amanda Oakley - 2019 http://www.dermnetnz.org Management of Common Skin Conditions In General Practice Contents Page Derm Map 3 Classic location: infants & children 4 Classic location: adults 5 Dermatology terminology 6 Common red rashes 7 Other common skin conditions 12 Common viral infections 14 Common bacterial infections 16 Common fungal infections 17 Arthropods 19 Eczema/dermatitis 20 Benign skin lesions 23 Skin cancers 26 Emergency dermatology 28 Clinical diagnosis of melanoma 31 Principles of diagnosis and treatment 32 Principles of treatment of eczema 33 Treatment sequence for psoriasis 34 Topical corticosteroids 35 Combination topical steroid + antimicrobial 36 Safety with topical corticosteroids 36 Emollients 37 Antipruritics 38 For further information, refer to: http://www.dermnetnz.org And http://www.derm-master.com 2 © Arroll, Fishman & Oakley, Department of General Practice and Primary Health Care, University of Auckland, Tamaki Campus. Management of Common Skin Conditions In General Practice DERM MAP Start Is the patient sick ? Yes Rash could be an infection or a drug eruption? No Insect Bites – Crop of grouped papules with a central blister or scab. Is the patient in pain or the rash Yes Infection: cellulitis / erysipelas, impetigo, boil is swelling, oozing or crusting? / folliculitis, herpes simplex / zoster. Urticaria – Smooth skin surface with weals that evolve in minutes to hours. No Is the rash in a classic location? Yes See our classic location chart .
  • WO 2017/173059 Al 5 October 2017 (05.10.2017) P O P C T

    WO 2017/173059 Al 5 October 2017 (05.10.2017) P O P C T

    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization I International Bureau (10) International Publication Number (43) International Publication Date WO 2017/173059 Al 5 October 2017 (05.10.2017) P O P C T (51) International Patent Classification: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, C12N 9/26 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/US20 17/024981 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 30 March 2017 (30.03.2017) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/3 15,400 30 March 2016 (30.03.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/457,584 10 February 2017 (10.02.2017) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 15/473,994 30 March 2017 (30.03.2017) US TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (71) Applicant: AMICUS THERAPEUTICS, INC.
  • Tanibirumab (CUI C3490677) Add to Cart

    Tanibirumab (CUI C3490677) Add to Cart

    5/17/2018 NCI Metathesaurus Contains Exact Match Begins With Name Code Property Relationship Source ALL Advanced Search NCIm Version: 201706 Version 2.8 (using LexEVS 6.5) Home | NCIt Hierarchy | Sources | Help Suggest changes to this concept Tanibirumab (CUI C3490677) Add to Cart Table of Contents Terms & Properties Synonym Details Relationships By Source Terms & Properties Concept Unique Identifier (CUI): C3490677 NCI Thesaurus Code: C102877 (see NCI Thesaurus info) Semantic Type: Immunologic Factor Semantic Type: Amino Acid, Peptide, or Protein Semantic Type: Pharmacologic Substance NCIt Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells, while VEGF is overexpressed in many tumors and is correlated to tumor progression. PDQ Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor