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Rigaku Americas E-Mail: Rinttyo@Rigaku.Co.Jp E-Mail: Info@Rigaku.Com Tel: +[81] 3-3479-0618 Tel: (281) 362-2300 FAX: +[81] 3-3479-6112 FAX: (281) 364-3628 Protein Crystallography Newsletter Volume 3, No. 8, August 2011 Crystallography in the news In this issue: August 2, 2011. Dr. Kalle Gehring, a professor in McGill University's Department of Crystallography in the news Biochemistry, has been awarded a Pilot Project Grant by the Parkinson Society of Photo of the month Canada (PSC) for his ongoing work that looks at the molecular and cellular processes that underlie neurological diseases like Parkinson's Disease (PD). Call for nominations: Carl Brändén Award BioSAXS-1000 Kratky camera August 03, 2011 Mitegen LLC, a provider of innovative consumables for X-ray diffraction, crystallography and protein crystallization to academic, pharmaceutical, industrial and Spotlight: UTMB, Sealy Center government researchers around the world, announced that it has signed an agreement Useful links for crystallography with AP Innovations to distribute their first product, the Quick Puck Loader for the Professional education opportunities Rigaku ACTOR robot. Science video of the month August 8, 2011. Coupling laser-driven, two-dimensional fluorescence imaging and high- Funny video of the month performance computer modeling, a six-member team - led by University of Oregon chemist Andrew H. Marcus and Harvard University chemist Alan Aspuru-Guzik - solved Last month's survey results the conformation of self-assembled porphyrin molecules in a biological membrane. Survey question of the month August crystallographic papers August 10, 2011. The availability of a postdoctoral fellowship was announced for the laboratory of Dr Ian Taylor (MRC National Institute for Medical Research, London), to Book reviews study the structure and mechanism of the recently described retroviral restriction factor SAMHD1. The primary focus of the project will be to establish the relationship between the biochemical and enzymatic properties of SAMHD1 and the mechanism of virus Mark Your Calender restriction. Multi-Pole Approach to Structural Biology November 16-19, 2011 August 12, 2011. In a paper published online in advance in Science, a team led by INTERNATIONAL INSTITUTE OF MOLECULAR AND investigators at the National Institutes of Health Vaccine Research Center reported their CELL BIOLOGY IN WARSAW use of X-ray crystallography and 454 pyrosequencing to characterize VRC01-like Ks. Trojdena 4, Warsaw, Poland antibodies derived from HIV-1-infected individuals. International conference discussing advances in August 17, 2011. One of the currently intriguing evaluations of a biotech firm is that of structural biology that have been promoted through Array Pharmaceuticals (ARRY). Its stock has been incapable of luring investors contributions of scientists with significant links to regardless of how large the number of its cancer products, how encouraging the news Poland. Open to participants from all countries. about clinical trial results, or how generous the upfront and promised milestone Official language is English. Abstract submission payments and royalties by the collaborating pharmaceutical companies. deadline: August 31st. Topics include: August 18, 2011. Imperial College London is seeking to appoint a Research Associate to Practical applications of structural biology investigate the roles of assembly factors involved in the assembly and repair of Biocrystallography Photosystem II using biochemical and structural biology techniques. The successful Structural bioinformatics applicant will be based within the Nixon group in the Department of Life Sciences at the Nucleic acids South Kensington Campus of Imperial College London. Multi-pole expansion to complex systems Panel discussion August 18, 2011. Laboratory of Bioinformatics and Protein Engineering (Warsaw, Poland) reported two medium-resolution, knowledge-based potentials for scoring protein-RNA Biophysical Society 56th Annual Meeting models obtained by docking: the quasichemical potential (QUASI-RNP) and the Decoys February 25-29 2012, San Diego, CA As the Reference State potential (DARS-RNP). Di Xia of NCI/NIH and Bill Cramer of Purdue August 24, 2011. The research and career path of Brian Kobilka, M.D., Professor of University are organizing a half-day symposium for Molecular and Cellular Physiology and Medicine at Stanford University, was extensively next year's Biophysical Society annual meeting on profiled in Nature. "Structure-Function of Hetero-Oligomeric Membrane Protein Complexes." Confirmed speakers include: August 24, 2011. What's One Billion Times Brighter Than the Sun? In the rolling Berkeley hills, under a dome that once housed its Nobel-Winning predecessor, lies the Leonid Sazanov of MRC, UK on structure of Advanced Light Source: an X-Ray generating system one billion times brighter than the complex I of the bacterial respiratory chain sun. Petra Fromme of Arizona State University on photosystem I and the use of X-ray lasers August 26, 2011. The three-dimensional structure of a site on an influenza B virus Robert Stroud of UC San Francisco on the protein that suppresses human defenses to infection has been determined by structure of Sec translocon researchers at Rutgers University (Prof. Gaetano Montelione) and The University of Bryan Krantz of UC Berkley on the Texas at Austin (Prof. Robert Krug). Their discovery also helps explain how influenza B translocation mechanism of anthrax toxin is limited to humans, and why it cannot be as virulent as A strains that incorporate new Di Xia on the mechanism and function of cyt genes from influenza viruses that infect other species. bc1 complex August 26, 2011. U.S. Department of Energy Office of Science's (DOE-SC's) national laboratories, including the Advanced Photon Source at Argonne National Laboratory, have enabled the discovery of a groundbreaking new drug treatment for malignant Photo of the Month melanoma, the deadliest form of skin cancer. The drug, Zelboraf (vemurafenib), "Future Structural Biologist" by Paul Swepston received Food and Drug Administration (FDA) approval on Wednesday, August 17, 2011. August 26, 2011. There are two vacancies for recent PhD graduates for NIH and American Cancer Society-funded postdoctoral positions in the Gaponenko laboratory in the Department of Bicohemistry and Molecular Genetics at the University of Illinois at Chicago. Call for nominations: 2012 Carl Brändén Award 2012 Awards of The Protein Society - The Carl Brändén Award We encourage submissions for "Photo of the Month." In the tradition of the late Carl Brändén, pioneer in structural biology, co-author of the Jpeg (250px wide) files should be sent to seminal text Introduction to Protein Structure and leader of the world-class synchrotron [email protected] along with a link to facility at Grenoble, the Carl Brändén Award - sponsored by Rigaku Corporation - is the high-res image (or we can host it). Entries must given to an outstanding protein scientist who has also made exceptional contributions in be original art (with specific permission for use) and the areas of education and/or service to the science. somehow connected to protein crystallography or structural biology. Submit a complete Award Nomination Package by September 1, 2011. Submission and questions should be addressed to: [email protected] Macromolecular Crystallography Class October 26-28, 2011 The Woodlands, Texas Register Product spotlight: BioSAXS-1000 Kratky Camera This is tailored towards the needs of macro- molecular crystallographers and their staff. Course format will be a series of short lectures on theory Introducing the BioSAXS-1000, a new SAXS camera based on a patented two- followed by hands-on activities with detectors, X-ray dimensional Kratky geometry, which produces significantly higher flux at the sample generators, and software. This class will also feature a with no need for desmearing. Designed to fit on an open port of a rotating anode training session on processing data with HKL. generator, or as a standalone system with a micro-focus sealed tube X-ray port, the small size and high flux performance make it the perfect instrument for incorporating SAXS into the workflow of your lab. Information derived from a SAXS experiment performed on a protein in solution has Rigaku BioSAXS-1000 been shown to be useful for predicting crystallizability, as well as in modeling after structure determination. And, in the absence of a successful crystallography experiment, the SAXS experiment can at a minimum provide information about the oligomeric state and shape of the molecule or complex. Request more information on Rigaku BioSAXS-1000. Lab spotlight: UTMB, Sealy Center UTMB, Sealy Center for Structural Biology and Molecular Biophysics The mission of the Sealy Center for Structural Biology and Molecular Biophysics (SCSB) is to elucidate the basic relationships between macromolecular sequence, structure and function, and to leverage this information into the understanding and treatment of disease. The center recently took delivery of the first Rigaku BioSAXS-1000 biological SAXS system, along with a FR-E+ Superbright X-ray source and an R-AXIS IV++ detector. Crystallographers associated with this center include Stanley J. Watowich, Kyung (Kay) H. Choi, Marc C. Morais, and Mark A. White (pictured in front of their new BioSAXS-100 system). Useful links for crystallography The Protein Data Bank in Europe (PDBe) has introduced PDBeXpress, an umbrella name for a set of easy-to-use yet powerful PDB analysis tools. PDBeXpress is a collection of tools that extract and present useful information and statistics from the PDB using PDBe
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