The Evolving Concept of Mitochondria: Cold Spring Harbor Laboratory | Meetings & Courses Program From Symbiotic Origins to Therapeutic Opportunities October 18 - 21, 2018 Poster Abstract Deadline: September 15 Meeting Website: meetings.cshl.edu/history18

Cold Spring Harbor, New York

Mary Herbert, Newcastle University, UK Organizers Henry Higgs, Dartmouth Medical School Anu Suomalainen**, University of Helsinki, Finland Judy Hirst, MRC Mitochondrial Biology Unit, UK John E. Walker**, MRC Mitochondrial Biology Unit, UK Ian Holt, MRC National Institute for Medical Research, UK Douglas C. Wallace**, Children's Hospital of Philadelphia & Howy Jacobs, University of Helsinki, Finland University of Pennsylvania Laurie Kaguni, Michigan State University Mila Pollock**, Cold Spring Harbor Laboratory Emine Koç, Marshall University Since it was first observed within cells at the end of the nineteenth century, our bacterial endosymbiont, the Carla Koehler, University of California, Los Angeles mitochondrion, has been interrogated from many perspectives. Initially described as a cytoplasmic ** Also Session Chairs & Speakers Edmund Kunji, MRC Mitochondrial Biology Unit, UK structure, then as the source of energy, later an organismal entity, and recently a component of many Nick Lane, University College London, UK diseases, the multi-faceted mitochondrion has engendered fascination from a broad spectrum of physical, Session Chairs Nils-Göran Larsson, Karolinska Institute, Sweden chemical, biological, and medical perspectives. Jennifer Lippincott-Schwartz, HHMI/Janelia Farm Research Campus Valerio Carelli, University of Bologna School of Medicine, Italy What is this cell-within-a-cell? Where did it come from? What is its relevance to our health and well being? Dan Mishmar, Ben-Gurion University of the Negev, Israel Anne Chomyn, California Institute of Technology Vamsi Mootha, Harvard Medical School How will mitochondrial knowledge affect the future? These are the questions we hope to discuss in this Marni Falk, Children's Hospital of Philadelphia stimulating meeting of modern mitochondriacs who will discuss the past and current status and future Carlos Moraes, University of Miami prospects of the field through their important contributions. Maria Falkenberg, University of Gothenburg, Sweden Michael Murphy, Medical Research Council, UK Toren Finkel, University of Pittsburgh David Nicholls, Buck Institute for Research on Aging The meeting will begin at 7 pm on Thursday, October 18th and conclude at 4:40 pm on Sunday, October 21st. György Hajnoczky, Thomas Jefferson University Nikolaus Pfanner, University of Freiburg, Germany Ferdinando Palmieri, University of Bari Aldo Moro, Italy Vincent Procaccio, University of Angers, France Rosario Rizzuto, University of Padua, Italy Peter Rich, Institute of Structural & Molecular Biology, UK Agnès Rötig, L'institut Imagine, France Topics Jared Rutter, HHMI/University of Utah School of Medicine • Mitochondrial Biology, Bioenergetics, • Mitochondrial Protein Import Systems and Leonid Sazanov, Institute of Science & Technology, Austria Metabolic Transporters Speakers Eric Schon, Columbia University Biogenesis and Disease Luca Scorrano, University of Padua, Italy • The Origins of the Organelle • Mitochondrial Diseases, Past and Present Alexey Amunts, Stockholm University, Sweden Paolo Bernardi, University of Padua, Italy Orian Shirihai, University of California, Los Angeles • Complex I - from Structure to Disease • Mitochondrial Regulation of Metabolism Charles Brenner, The University of Iowa Eric Shoubridge, McGill University/MNI, Canada • Mitochondrial DNA: Structure, Function and • Mitochondria, Calcium signaling, and Cell Death David Chan, California Institute of Technology Bruce Spiegelman, Harvard Medical School • Mitochondrial Dynamics and Quality Control Navdeep Chandel, Northwestern University, Feinberg School of Medicine James Stewart, Max Planck Institute for Biology of Ageing, Germany Inheritance Aleksandra Trifunovic, University of Cologne, Germany • Mitochondrial Expression System and • Novel Approaches to Mitochondrial Therapy J. Antonio Enriquez, Centro Nacional de Investigaciónes, Spain Michael Gray, Dalhousie University, Canada Richard Youle, National Institutes of Health Proteome • Wrap-up Discussion: Preserving the History of Claes Gustafsson, University of Gothenburg, Sweden Ian Young, Australian National University, Australia Mitochondrial Research Marcia Haigis, Harvard Medical School Massimo Zeviani, MRC Mitochondrial Biology Unit, UK