Preanalytical Factors Affecting the Mean Platelet Volume: a Review
CORE Metadata, citation and similar papers at core.ac.uk Provided by University of Debrecen Electronic Archive Global Journal of Hematology and Blood Transfusion, 2016, 3, 19-22 19 Preanalytical Factors Affecting the Mean Platelet Volume: a Review Katalin S Zsóri1,2, Judit M Mahalek3, Mohammad A Mokarrami4, Zoltán Csiki5 and Amir H Shemirani2,6,* 1Central Pharmacy, Erzsébet Hospital, Sátoraljaújhely; 2LabPharm Kft, Sátoraljaújhely; 3Central Intensive Care Unit, Medical Center, Hungarian Defense Forces, Budapest; 4Department of Surgery, Bács-Kiskun Hospital, Kalocsa; 5Department of medicine, Debrecen university, Debrecen; 6MTA-DE Vascular Biology, Thrombosis and Hemostasis Research Group, Hungarian Academy of Sciences, Debrecen, Hungary Abstract: Mean platelet volume (MPV) as an indicator of platelet activation is a subject of many studies. Since the introduction of automated hematology analyzers, many authors described mean platelet volume as a marker for different pathologic conditions. It is also known that numerous preanalytical conditions could affect MPV results. Specimens are usually tested several hours after blood collection. There are some specific hematology analyzers which are in use by the majority of hematology laboratories. This review demonstrates some important aspects related to MPV measurement in routine laboratory. Keywords: Mean platelet volume, Preanalytical variables, Hematology analyzer, Anticoagulation, Blood. INTRODUCTION can estimate cell sizing and counting. A major disadvantage of the impedance method is that cell size Mean platelet volume (MPV) has been discussed as analysis cannot discriminate large platelets from other an indicator of platelet function: larger platelets are similarly sized particles, such as small or fragmented more reactive and related to a shortened bleeding time. red cells [7]. It is established that the platelet volume is correlated with platelet activation and function [1].
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