International Journal of Molecular Sciences Article KCNK18 Biallelic Variants Associated with Intellectual Disability and Neurodevelopmental Disorders Alter TRESK Channel Activity Lisa Pavinato 1,2 , Ehsan Nematian-Ardestani 3, Andrea Zonta 4, Silvia De Rubeis 5,6,7,8 , Joseph Buxbaum 5,6,7,8,9,10, Cecilia Mancini 11 , Alessandro Bruselles 12, Marco Tartaglia 11, Mauro Pessia 3,13 , Stephen J. Tucker 14, Maria Cristina D’Adamo 3,*,† and Alfredo Brusco 1,4,*,† 1 Department of Medical Sciences, University of Turin, 10126 Turin, Italy;
[email protected] 2 Center for Molecular Medicine Cologne, Institute of Human Genetics, University of Cologne, 50931 Cologne, Germany 3 Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, MSD-2080 Msida, Malta;
[email protected] (E.N.-A.);
[email protected] (M.P.) 4 Unit of Medical Genetics, “Città della Salute e della Scienza” University Hospital, 10126 Turin, Italy;
[email protected] 5 Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;
[email protected] (S.D.R.);
[email protected] (J.B.) 6 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA 7 The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA 8 Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Citation: Pavinato, L.; 9 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Nematian-Ardestani, E.; Zonta, A.; New York, NY 10029, USA De Rubeis, S.; Buxbaum, J.; Mancini, 10 Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA C.; Bruselles, A.; Tartaglia, M.; Pessia, 11 Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, 00165 Rome, Italy; M.; Tucker, S.J.; et al.