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NEK2 Antibody Order 021-34695924 Orders@Ab-Mart.Com Support 400-6123-828 50Ul Support1@Ab-Mart.Com 100 Ul √ √ Web

TD7296 NEK2 Antibody Order 021-34695924 [email protected] Support 400-6123-828 50ul [email protected] 100 uL √ √ Web www.ab-mart.com.cn Description: Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly. NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis. Involved in the regulation of centrosome disjunction.Phosphorylates and activates NEK11 in G1/S-arrested cells.Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. Uniprot:P51955 Alternative Names： HSPK 21; HsPK21; NEK 2; NEK2; NEK2_HUMAN; NEK2A; Never in mitosis A-related kinase 2; NIMA (never in mitosis gene a) related kinase 2; NimA like protein kinase 1; NIMA related kinase 2; NimA related protein kinase 2; NimA-like protein kinase 1; NimA- related protein kinase 2; NLK 1; NLK1; Serine/threonine-protein kinase Nek2; Specificity: NEK2 Antibody detects endogenous levels of total NEK2. Reactivity:Human, Mouse, Rat Source:Rabbit Mol.Wt.: 51kD; 52kDa(Calculated). Storage Condition: Store at -20 °C. Stable for 12 months from date of receipt. Application: WB 1:1000-1:2000；IHC/IF 1:50-1:500.

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Identification of Key Candidate Genes for Colorectal Cancer by Bioinformatics Analysis
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NEK2 Antibody (Aa287-299) Rabbit Polyclonal Antibody Catalog # ALS11259
10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 NEK2 Antibody (aa287-299) Rabbit Polyclonal Antibody Catalog # ALS11259 Specification NEK2 Antibody (aa287-299) - Product Information Application IHC Primary Accession P51955 Reactivity Human Host Rabbit Clonality Polyclonal Calculated MW 52kDa KDa NEK2 Antibody (aa287-299) - Additional Information Gene ID 4751 Anti-NEK2 antibody IHC of human testis. Other Names Serine/threonine-protein kinase Nek2, 2.7.11.1, HSPK 21, Never in mitosis NEK2 Antibody (aa287-299) - Background A-related kinase 2, NimA-related protein kinase 2, NimA-like protein kinase 1, NEK2, Protein kinase which is involved in the control NEK2A, NLK1 of centrosome separation and bipolar spindle formation in mitotic cells and chromatin Target/Specificity condensation in meiotic cells. Regulates aa 287-299 of Human NEK2 protein. centrosome separation (essential for the formation of bipolar spindles and high-fidelity Reconstitution & Storage chromosome separation) by phosphorylating Store vial at -20 C prior to opening. Dilute centrosomal proteins such as CROCC, CEP250 only prior to immediate use. For extended and NINL, resulting in their displacement from storage aliquot contents and freeze at -20 C or below. Avoid cycles of freezing and the centrosomes. Regulates kinetochore thawing. microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in Precautions regulation of mitotic checkpoint protein NEK2 Antibody (aa287-299) is for research complex via phosphorylation of CDC20 and use only and not for use in diagnostic or MAD2L1. Plays an active role in chromatin therapeutic procedures. condensation during the first meiotic division through phosphorylation of HMGA2.
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anti- NEK2 antibody Product Information Catalog No.: FNab05652 Size: 100μg Form: liquid Purification: Immunogen affinity purified Purity: ≥95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: None IsoType: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) Background Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation(essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80.Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1.Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2.Phosphorylates: PPP1CC; SGO1; NECAB3 and NPM1.Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Phosphorylates CEP68 and CNTLN directly or indirectly(PubMed:24554434). NEK2-mediated phosphorylation of CEP68 promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis(PubMed:25704143). Involved in the regulation of centrosome disjunction(PubMed:26220856). Isoform 1: Phosphorylates and activates NEK11 in G1/S- arrested cells. Isoform 2: Not present in the nucleolus and, in contrast to isoform 1, does not phosphorylate and activate NEK11 in G1/S-arrested cells. Immunogen information Immunogen: NIMA(never in mitosis gene a)-related kinase 2 1 Wuhan Fine Biotech Co., Ltd.
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