Enabling Innovation We’Re Proud to Partner with Colorado Bioscience Association to Bring You More Than 1.7 Million Laboratory and Research Products

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2019 - 2020 Enabling Innovation We’re proud to partner with Colorado Bioscience Association to bring you more than 1.7 million laboratory and research products.

You’ll ﬁnd a full range of antibodies, reagents, and other life sciences materials, including exclusive Applied Biosystems™ and Invitrogen™ products. Plus, take advantage of cost savings, incentives, and value-added services available through the Fisher Scientiﬁc channel.

We’re proud to be your exclusive partner for:

Lab essentials, supplies, and equipment R&D collaboration Scientiﬁc instruments Clinical trial support Encompass Procurement Services Production efﬁciencies Supply chain optimization Life sciences tools

Visit cobioscience.com to learn more. ISORDERS 8

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ISORDERS 8 2019-2020 2019 - 2020 // BIOSCIENCE COLORADO 3 We’re proud to work with our partners, across the state and nationally. We know innovation and advancement doesn’t happen without collaboration, and Colorado has demonstrated we are particularly good at boosting each other to positions where we all succeed. There is something different about Colorado. It’s more than our beautiful natural sur- roundings and abundant sunshine. It goes beyond You will find that in the unique approaches industry our favorable business climate and talented work- is innovating to address pain management beyond force. In Colorado, companies and organizations the traditional prescriptions. The problem is too share a commitment to working together and helping large for any one person to solve. But, working each other solve business challenges. This issue high- together, Colorado is pioneering unique solutions lights many of our accomplishments that have been that are improving lives. We also recognize a few built on combined strengths. exceptional individuals in our Rising Star profiles, For the Colorado BioScience Association—and our while celebrating the networks and mentors they entire community—it begins and ends with the have used to climb to their current elevation. patient. In these pages we look at how those patients Colorado’s life science companies raised $1 billion in are influencing the entire process of product devel- 2018! We are only able to tout our successes through opment from the first stages of innovation. We’re the strength of the entire industry. We are proud of engaging patients as partners in research and devel- our sector’s continued advancement with another opment, and showing incredible results with their year of successful financing. Colorado BioScience input. We also explore the links between the var- Association works actively to accelerate investment ious institutions and the brilliant minds they host. in the state’s bioscience companies and will continue Colorado is home to exceptional leaders in their to work closely with our public and private partners respective fields. When they collaborate, combined to increase the industry’s access to capital. As new with the support of both new and established insti- companies, fresh investments, and industry leaders tutions, breakthroughs happen. If our community grow here in Colorado, there will be additional oppor- sees a challenge, we bond together to address it. tunities for everyone. We’re ready to work with all. It’s in our nature.

Jennifer Jones Paton President and CEO, Colorado BioScience Association

Published by: Designed by: Colorado BioScience Association The Bawmann Group 600 Grant Street, Suite 306 2137 S Birch Street Denver, CO 80203 Denver, CO 80222 www.cobioscience.com www.goteamtbg.com 303.592.4073 303.320.7790

4 BIOSCIENCECOLORADO // 2019-2020 VISIT DENVER IS PROUD TO SUPPORT THE COLORADO BIOSCIENCE ASSOCIATION

GREAT CITIES INSPIRE GREAT MEETINGS

There’s never been a better time to meet in Denver! Enjoy a wide range of delicious dishes and cocktails at one of the many gourmet food halls all across the city. And with rail service from Denver International Airport to Denver Union Station, you’ll have more time to explore them all. The Mile High City has the facilities and services your meeting needs. Learn more at DENVERMEETINGS.COM WRITTEN BY MARK CRAWFORD WITH CONTRIBUTIONS FROM PRIMAVERA GROUP

A DYNAMIC BUSINESS CLIMATE. World- class academic and research institutions. An educated, motivated workforce. A supportive bioscience ecosystem with a shared commitment to medical breakthroughs for patients. Multiple factors contribute to Colorado’s reputation as an exceptional place to launch, grow, relocate, or commercialize a life science company. For many life science innovators and researchers, the biggest draw is Colorado’s culture of collaboration. Companies, organizations and research institutions share a commitment to working together to solve healthcare challenges and create medical breakthroughs for patients.

6 BIOSCIENCECOLORADO // 2019-2020 ACCELERATING CANCER RESEARCH

Sharing resources, talent, and expertise expedites the pace of discovery, pushes development, and delivers life-saving products to patients in need much more quickly. For many of these reasons, Children’s Hospital Colorado and the University of Colorado School of Medicine attracted one of the country’s leading cancer researchers, Dr. Terry J. Fry, co-director of the Human Immunology and Immunotherapy Initiative and director of Cancer Immunotherapy at the University of Colorado School of Medicine. Dr. Fry was excited to join the team, saying, Dr. Terry Fry “one reason I came to Colorado was that I would be collaborating with outstanding scientists doing good science in this field, and not just trials. We have strong groups studying immunology at large academic institutions in Colorado. Biotech spinoffs from the university have experience in immunology and immunotherapy, and plenty of great biotech talent graduates every year. These assets make Colorado an ideal place to partner with others to solve immunologic challenges, such as developing CAR-T cell therapies to fight cancer.”

2019-2020 // BIOSCIENCECOLORADO 7 ADVANCING HEALTH developing potential cures for certain illnesses. WITH ORGAN AND Eager to move the technology into clinical trials, TISSUE REPLACEMENT the Colorado team is leading a partnership with Stanford University and Columbia University to Collaboration is one of the four strategic drivers advance this research. of a world-class, multi-institutional center The Gates Biomanufacturing Facility, affiliated headquartered on the University of Colorado with the Gates Center, is a campus-wide part- Anschutz Medical campus, the Gates Center for nership that includes the University of Colorado Regenerative Medicine. From treating painful School of Medicine, Children’s Hospital of skin conditions in children with induced plurip- Colorado, UCHealth, and the Gates Frontiers otent (iPS) cells to using stem cells to improving Fund. It is one of only six combined cell therapy quality of life for injured people and their pets, and protein manufacturing facilities in the U.S. Colorado boasts intense activity in the field of and is focused on collaborating with its clients regenerative medicine. to accelerate the translation of their lab discov- A team of researchers from the Gates Center eries into human clinical trials as efficiently and recently developed an improved method for cost effectively as possible. In 2018, the facility reprogramming diseased skin cells into iPS manufactured its first clinical trial-grade product stem cells that it is sharing with researchers for direct infusion into myeloma patients, to be on and off-campus– an important step toward carried out by a private research firm.

BUILDING FOR MEDICAL INNOVATION

Fitzsimons Innovation Community counts Tenant Ventria Bioscience was able to take the Gates Biomanufacturing Facility as one of advantage of this collaborative environment its 75 tenants in a community built to foster when they discovered a novel method for breakthroughs. “The Fitzsimons Innovation making beneficial proteins, called ExpressTec. Community is built on the value of collaboration. This process allows for large-scale and afford- With an integrated community of startup, growth able production of these unique molecules. and commercial companies, academic research Ventria collaborated with Edwin de Zoeten, MD, groups and partners on campus with clinical and associate professor of pediatrics and director technical expertise, partnerships are of the Pediatric Inflammatory Bowel Disease ingrained in the environment. With Center at Children’s Hospital Colorado, to apply two million outpatient visits annually, this process to the protein recombinant lacto- 25,000 employees and more than 4,500 ferrin. Working together, they discovered that students, we can really do anything on this protein can help regulate immune cells by this campus.” says Steve VanNurden, skewing the immune cell population toward an president and CEO of Fitzsimons anti-inflammatory population. “Our next step is Innovation Community. to confirm this in human clinical studies, which The companies within Fitzsimons is under way,” says Scott Deeter, president and Innovation Community enjoy access CEO of Ventria Bioscience. “If this proves effec- to valuable clinical trial programs tive in humans, it will be a novel therapeutic for through major healthcare providers inflammatory bowel disease. Without Dr. de at the adjacent University of Colorado Zoeten’s tenacity and expertise, and the ease Anschutz Medical Campus, including of working together for a common purpose to UCHealth, Children’s Hospital improve patient outcomes, we would not have Colorado, and the VA Eastern Colorado made this discovery.” Health Care System.

8 BIOSCIENCECOLORADO // 2019-2020 DEEPENING CONNECTIONS Innosphere, an incubator in Fort Collins, pro- IN NORTHERN COLORADO vides support to its high-tech startups and scaleup client companies by fostering collabo- Collaboration is on the rise in northern Colorado ration among its tenants and strategic partners. for several reasons, notes Dr. Gary Luckasen, an Innosphere client companies and CSU faculty MD and cardiologist at UCHealth, medical director members run trials and develop projects with for UCHealth North Research, and principal research teams at UCHealth. New Innosphere investigator for multiple collaborative projects companies are connected to experienced with Colorado State University and UCHealth. advisors and corporate partners to accelerate “Business support through Innosphere and their growth. “Out-of-state organizations and CSU Ventures and increased research focus by researchers are coming to Colorado to take UCHealth are the key drivers,” he says. “There advantage of our cutting-edge infrastructure,” is also an increased frequency of collaborative says Walker. “Also, with the opening of the research between industry—especially bio- Translational Medicine Institute at Colorado tech—and UCHealth, Colorado State University, State University, our community will have more The University of Colorado School of Medicine, opportunities to support research on both the and the CSU College of Veterinary Medicine and veterinary and human side.” Biomedical Sciences.” The Translational Medicine Institute will draw Forging collaborations across disciplines can lead on established areas of CSU research expertise to exciting outcomes such as the 2018 Zoobiquity in orthopedics, biomedical engineering, immu- Colorado conference that was co-hosted by the nology, infectious disease, surgical advances Gates Center for Regenerative Medicine at the and other medical fields. The Institute will also University of Colorado Anschutz Medical Campus bring together educators and innovators from and CSU College of Veterinary Medicine and academia, industry, public agencies, and other Biomedical Sciences. The institutions brought entities to pursue development of promising clinicians, scientists, patients and the public medical technologies, with special attention to together to explore healthcare possibilities those with potential for commercialization. emerging from the intersection of human and veterinary medicine.

2019-2020 // BIOSCIENCECOLORADO 9 FOSTERING SCIENTIFIC BREAKTHROUGHS AT THE UNIVERSITY OF COLORADO

At the University of Colorado-Boulder, the BioFrontiers Institute fosters cross-disciplinary research across eleven academic departments. BioFrontiers Institute is led by Nobel Laureate Dr. Tom Cech and Chief Scientific Officer Dr. Leslie Leinwand. It was founded on the premise that great research triumphs are the product of interdisciplinary inquiry and collaboration. This unique program trains the next generation of leaders, laying the foundation for bioscience advances. The ALSAM Foundation recently provided $2 million in grants to Dr. Leslie Leinwand foster collaborative research between the- BioFrontiers Institute and the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences (SSPPS). The goal is to assist cross-disciplinary research among pharmaceutical scientists at the SSPPS and the interdisciplinary bioscien- tists at the BioFrontiers Institute. “This program will stimulate our BioFrontiers faculty and students to work with our SSPPS colleagues at Anschutz to develop new therapeutics in the areas of cancer, muscle dis- Dr. Tom Cech ease, and diabetes,” said Dr. Cech.

WORKING TOGETHER FOR BETTER LIVES Through the technologies we provide and partnerships we forge, we unlock the potential of blood and cellular therapies to ultimately enable better lives for patients throughout the world.

10 BIOSCIENCECOLORADO // 2019-2020 Amy Galliher-Beckley goes straight to consumers with over-the-counter ovulation test

Most startups seek venture funding for a concept, but MFB Fertility, founded and led by Amy Galliher- Beckley, PhD, already has a product on the market, Proov™. MFB’s at-home ovulation confirmation TRANSLATING DISCOVERIES startups to identify technical experts among test, is currently sold INTO IMPACT the faculty to help with their product develop- on Amazon, with initial development and FDA ment. Similarly, it facilitates access to the wealth registration supported In the fall of 2018, University of Colorado of knowledge on the campus for multinational by crowdfunding. Anschutz Medical Campus and GlaxoSmithKline companies. CU Innovations Executive Director (GSK), joined forces to advance immunothera- Kimberly Muller underscores the ambitious Her product’s unusual route to commercializa- pies for cancer, with a special focus on check- vision for her office. “We do not want to be a tra- tion results from Galliher-Beckley’s incredible commitment to getting the test to consumers point inhibitors, which have shown promise ditional technology transfer office, we want to be as quickly as possible—in less than a year after in clinical trials. the engine of innovation bringing best practices creating the prototype. She knew its value from Dr. Richard Schulick and Dr. Yuwen Zhu of and resources to leverage the exciting research her own experience of multiple miscarriages Anschutz Medical Campus recently identified taking place on the campus and create broader and undergoing IVF to have her first child. a series of novel checkpoint inhibitors, which economic and health impact.” “Because of my background in endocrinology, may have the potential to promote anticancer University of Colorado Anschutz Medical Campus I guessed that my issue might be low pro- responses in cancer patients. Chancellor Don Elliman sees great potential in gesterone. When progesterone supplements CU Innovations recognized the commercial developing more academia-industry collabora- helped me conceive, I realized it would be potential in the discovery and worked to find a tions and deepening university ties with industry great if women could track their own proges- pharmaceutical partner to further develop this to translate academic discoveries into services terone levels.” technology. They decided that GSK’s Discovery and products that will transform healthcare. Even today, Galliher-Beckley stays motivated by interacting with consumers. Partnership with Academia was an excellent “Our cutting-edge science is opening the doors fit for developing this collaborative research for broader academia-industry collaboration,” “I love hearing about how Proov has helped and reached out to the pharmaceutical giant. says Elliman. “We are confident that bringing our people take control of their fertility and avoid “GlaxoSmithKline brings world-class pharmaceu- world-class researchers together with premier the struggles I went through,” she says. “I want to get these tests in the hands of all the par- tical expertise on-board to the Anschutz Medical life science leaders will only lead to many more ents-to-be who would benefit from them and Campus,” indicates Brian Bellesheim, business positive impacts.” development manager at CU Innovations. “They develop new products that would make fertility have the right mix of resources and scientific Colorado’s reputation as a center for collabora- tracking even easier.” focus to develop new cancer treatments, and the tive research, innovation, and commercialization Access to capital and collaborative partner- right approach to working with academia, with continues to grow. In response, an increasing ships are important to MFB. MFB’s efforts in a commitment to finding cures for disease, in a number of life science companies and investors seeking capital have been supported by the collaborative fashion.” will locate in Colorado to take advantage of our Colorado BioScience Association (CBSA). MFB collaborative nature and work with some of the took advantage of CBSA’s state supported CU Innovations not only partners with pharma- best scientists in the country. grant which resulted in Galliher-Beckley’s ceutical companies, but also works with local attendance at various investor conferences throughout the U.S. Those efforts ultimately Future Fitzsimons Innovation Community led to crucial seed funding and a connection with a startup accelerator. Galliher-Beckley continues to travel to tell people about her product. MFB recently presented Proov at SXSW to win the Startup of the Year competition there. For Galliher-Beckley, this work is a mission to change how healthcare treats fertility. “It shouldn’t be a luxury.”

2019-2020 // BIOSCIENCECOLORADO 11 Anna Bowman of Virginia wears Green Sun Medical’s Dynamic Brace. The company solicited the input of Anna and other patients that will encourage them to wear the brace as many hours as possible.

12 BIOSCIENCECOLORADO // 2019-2020 Replenishing the world’s blood supply relies on donors, especially those who make repeat donations.

WRITTEN BY TYLER SMITH

IN OCTOBER 2017, ANNA BOWMAN CAME OUT OF “positive” about her brace, so much so that she is an elastic ring system with modular parts that HER SHELL. wore it 22 hours a day, seven days a week. But can be tailored to each patient and adjusted to It wasn’t a matter of shedding shyness for the now she also discovered why plastic back braces, deliver focused corrective pressure to the spine 15-year-old from Winchester, Virginia. Rather, she which haven’t changed much in nearly a half-cen- over a period of time. Sensors also record how set aside what she calls a physical “shell” – a rigid tury, don’t encourage regular use. many hours patients wear the brace. back brace she had worn for more than a year to “Bending down was hard; so was moving back, In developing the device, Green Sun Medical’s correct her adolescent idiopathic scoliosis: severe and side to side,” Anna said. Sitting through a leadership drew on another resource: the spinal curvature with no known cause. movie in the rigid brace was impossible. She insights of Anna and other young patients who Without a brace, Anna was likely to face painful couldn’t bend over to pick up a dropped pencil. pinpointed necessary changes if they were to and expensive back surgery. Searching for the The brace rubbed against and irritated her skin. wear the brace faithfully. A special shirt she had to wear under it made best device, her parents connected with the The youthful input was a necessity, said Green Virginia summer days especially uncomfortable. National Scoliosis Center and Luke Stikeleather, Sun Medical’s Chief Technical Officer Matt one of the few orthotists in the nation trained to Then, in the fall of 2017, an alternative emerged. Thompson, a biomechanical engineer. construct the European-designed Rigo-Chêneau Stikeleather informed the Bowmans that Fort “The patient has the option to put the device on brace that they ultimately chose. Collins, Colorado-based Green Sun Medical, LLC or not,” Thompson said. “I can make the most had developed a new brace. Braces work: one study showed that roughly amazing device in the world but if the patient 90 percent of scoliosis patients who wear them Green Sun Medical’s Dynamic Brace, now in a doesn’t use it, it might as well be in the dumpster.” at least 13 hours a day avoid surgery. Anna felt National Scoliosis Center-sponsored clinical trial,

2019-2020 // BIOSCIENCECOLORADO 13 Green Sun Medical and other innovative life “There is no doubt that biomechanically we have a science companies in Colorado recognize the brace that is going to knock it out of the park for 80 necessity of incorporating patient input in percent of these kids,” he said. But biomechanics the development and alone wouldn’t ensure suc- design of their products. cess with 10- to 14-year-old And they’re not alone. girls, who are about seven The influential journal times more likely than Health Affairs declared boys to have scoliosis. patient engagement “We wanted to find out “the blockbuster drug” what they didn’t like of the twenty-first cen- about the brace – what tury, noting the evi- would make them take it dence-based view that off,” Haggard said. “We involving patients in told them, ‘If you’re too their care often leads to nice we’re not going to be better outcomes. able to help you. We need In recent years, there to know everything that’s has been a shift in how drug and device com- wrong [with the brace], even the littlest things.’” panies engage patients and look to them as Anna Bowman liked that the Dynamic Brace partners in research and development. The made it easier to move, but she had plenty of value of patient input is reflected at the FDA suggestions for improvement. The first version through initiatives like Patient-Focused Drug took too long to put on, she told Haggard and Development and the Patient Preference Thompson, and it had three thick, uncomfort- Initiative launched through FDA’s Center for able layers. It had a fin-like part that poked out in Devices and Radiological Health. Successful back. The brace pinched her ribs and hips when legislative proposals like the 21st Century Cures she sat down. A shirt over the brace went up to Act also emphasize the need for patient engage- the neck, an invitation to unwelcome questions. ment, with provisions designed to define and standardize the use of patient experience data “I didn’t want anyone saying, ‘Hey, what’s that?’” in regulatory decision making. Anna said. Green Sun Medical CEO Jamie Haggard said “Patients don’t want anyone to know they’re the company quickly realized that getting input wearing a brace,” Thompson acknowledged. The Anna Bowman about the brace from those who would wear it company went back to the drawing board and of Virginia was a must. addressed those issues with fixes like additional padding on the brace rings, thinner fabric and more. “It’s now less obvious than a thin plastic brace,” Thompson said. Incorporating a patient or consumer viewpoint is also vital to industry problem solving. On a mid-February morning, a lifesaving operation quietly hummed in an unlikely space: an office building in the shadow of the foothills over Golden, Colorado. Blood donors lay comfortably in recliners at the proud to protect Vitalant™ Denver West donation center, one of the organization’s eight blood-collection facili- bioscience innovations ties in Colorado. Hospitals and other providers depend on these donors to meet shifting demand patent / trademark / copyright / litigation for precious blood supplies. “Having enough blood products to go around is a constant battle,” said Liz Lambert, a marketing The Rocky Mountain Region’s largest intellectual and communications specialist for Vitalant. She property firm and proud member of the Colorado noted that in Colorado, Vitalant’s base of apher- Bioscience Association. esis donors – those who supply red blood cells, platelets and plasma separated from blood that sheridanross.com 303.863.9700 Denver / Broomfield is then returned to their bodies – has hovered for several years at around 3,100. Donors of platelets,

14 BIOSCIENCECOLORADO // 2019-2020 Abby Wright gets cancer patients access to cutting- edge diagnostic tests

Abby Wright, Senior Director of Reimbursement at Biodesix, Inc., finds her job—negotiating with health plans to get the company’s tests covered— highly meaningful. “My work makes our tests available to lung cancer patients who need them,” Wright says. “That can get them on the right treatment much faster than would Lakewood-based Terumo BCT’s Trima Accel®, an apheresis system designed to improve otherwise be possible or spare them efficiency and donor comfort. unnecessary worry. I can’t imagine a more rewarding career.” which have a shelf life of only five days, make Biodesix offers three innovative, rapid blood- up less than 5 percent of the overall donor base. based tests that identify actionable lung It’s therefore vital that blood centers retain tumor mutations, measure the immune dedicated donors, said Michelle Marks, Director response to lung tumors, and distinguish of Global Product Marketing for Lakewood, benign from potentially cancerous lung Colorado-based Terumo BCT, Inc., whose port- nodules, respectively. folio of products includes automated blood col- “We present clinical data to Medicaid, lection systems. “Repeat donation is extremely President of New Product Ideation, Tom Felt. Medicare, and major insurers showing that important,” she said. “We wouldn’t be able to During product development, engineering and Biodesix’s tests improve outcomes and provide a lot of blood products without donors.” business design specialists routinely visit cus- reduce the overall cost of care,” says Wright. Enter Terumo BCT’s Trima Accel®, which handles tomers and play the “fly on the wall,” as he put “That can be really challenging because the roughly half of all apheresis donations worldwide, it, to understand their needs. treatment landscape and standards are always changing.” Feedback from blood centers helped Terumo BCT tweak the Trima Accel 7. During testing in Asia, for In Wright’s six and a half years at Biodesix, example, donors and techs told developers that she’s led the team that secured coverage for an earlier version of the system better suited the VeriStrat®, the proteomic immune response larger veins of Western donors than their coun- test, and oversaw the three-year planning terparts in Japan and China. The machine pulled and execution of bringing billing in-house, blood too quickly from Asian donors, triggering including the research to show that it would machine alarms and donor consternation. improve revenue. “That was a big ‘eureka,’” Felt said. An added fea- She credits her success to a combination ture now allows technicians to customize blood of her initiative—taking every opportunity flow based on each donor’s height, weight and to learn and contribute—and great men- vein access, reducing the number of alarms by tors, both within the company and in the half. Another fix shortened the machine reset Colorado bioscience community. time between donors – a key improvement in according to Christine Romero, corporate com- “Biodesix’s involvement with CBSA has busy centers. munications specialist for Terumo BCT. The compa- opened a lot of doors,” says Wright. ny’s next-generation version, Trima Accel 7®, slated Zimmer Biomet, whose Spine Division headquar- “Through Colorado BioScience Institute’s for release in the United States later this year, will ters in Westminster, Colorado, also improved its Executive Leadership Program, I was include software and hardware improvements biomedical technology by listening to patient assigned a mentor who has founded and that aim to make blood collection more efficient concerns. The company’s FDA-approved Mobi-C® run multiple biotech companies, and he and and inviting for donors. Cervical Disc is an alternative to anterior cervical the program director have provided really discectomy and fusion (ACDF) to treat degener- insightful, constructive advice.” Terumo BCT centers its design philosophy on ation of the rubbery discs that cushion verte- the Japanese concept of “gemba,” roughly trans- brae in the upper and lower spine. When discs lated as “the real place,” said the company’s Vice

2019-2020 // BIOSCIENCECOLORADO 15 The Mobi-C Cervical Disk from Zimmer Biomet improves neck mobility after a discectomy, a key patient concern.

fail, the space between the vertebrae narrows, compressing nerves and causing pain that often radiates from the spine to the extremities. In ACDF, surgeons remove the diseased disc, restore the space between the vertebrae and fuse the bones. That alleviates nerve pain but limits the patient’s neck mobility and transfers stress to the adjacent vertebrae, which may lead to subse- quent surgeries, said Zimmer Biomet Director of Strategic Communications Mark Richards. Richards called ACDF an “established technology” that satisfies most surgeons, but patients delivered a different message. “Patients want to reduce their pain, but not at the cost of mobility,” he said. “They also don’t want to be back for another surgery.” Those problems spurred the Mobi-C®’s development. As in ACDF, surgeons decompress the nerves, but instead of fusing the vertebrae, they insert an artificial disc with a mobile bearing that allows natural motion in the neck and reduces stress between the implant and the bone.

smaller market niche – literally. The company Silvergate Pharmaceutical, Inc. develops markets three FDA-approved drugs for pediatric pediatric versions of adult medications that patients (two for high blood pressure and another make it easier for caregivers to administer that treats both acute lymphoblastic leukemia and kids to take. and polyarticular idiopathic juvenile arthritis). importantly, they meet the needs of patients with The medications, which repurpose molecules limited ability to speak for themselves. already used in adult medications, don’t require compounding by pharmacists, which involves, “Kids aren’t just different-size patients, they’re for example, crushing tablets and combining really different individuals in the way their the powder with a liquid. “The compounded bodies have evolved and developed,” Segrave drugs can taste terrible or require injection,” said said. “It’s ridiculous to think that a patient who “Alleviating [patients’] pain is the number-one Silvergate Pharmaceuticals CEO Frank Segrave. is two months old will get the same amount of goal, but a secondary goal, which I think has In addition, the compounding process may differ medication as one three years old. Our medica- been overlooked in ACDF, is to respect the nat- from pharmacy to pharmacy, a concern for care- tions are designed to help physicians, nurses and ural physiology and restore quality of life and the givers administering the medications. pharmacists properly titrate and tailor the dose of the product to each specific patient.” activities of daily living,” Richards noted. Silvergate Pharmaceuticals developed kid- Silvergate Pharmaceuticals, Inc., based in Greenwood friendly, sweet-tasting liquid medications that Successful companies, it seems, listen to and learn Village, Colorado, customizes products to fill a caregivers can dose reliably by body weight. Most from their end users.

16 BIOSCIENCECOLORADO // 2019-2020 We’re committed to ﬁnding precision treatments. stop us from Cancer can’t making real progress. In our ongoing pursuit to improve the lives of people living with cancer, Clovis Oncology is committed to realizing the promise of precision medicines for cancer. We seek to develop targeted therapies to better serve patients and ensure the right drug gets to the right patient. Learn more about our innovative treatments in development for cancer today. clovisoncology.com

2019-2020 // BIOSCIENCECOLORADO 17 THE BOETTCHER FOUNDATION’S WEBB-WARING Biomedical Research Awards program supports scientific innovation in Colorado by providing biomedical research funding for early career investigators at the state’s research institutions. Recipients, known as “Boettcher Investigators,” are awarded research grants of $235,000, cov- ering up to three years of biomedical research. The grants support Boettcher Investigators in establishing their research, helping them become competitive for major awards from federal agencies and private sources. While the foundation’s investment in biomedical research, as well as its support of scholarships and nonprofit organizations, have served every part of Colorado, the University of Colorado’s BioFrontiers Institute holds a unique position in that many of the foundation’s focus areas inter- sect in the facility. Currently three Boettcher Investigators make their research homes in the BioFrontiers Institute. Among them is Loren Hough, an assistant professor whose research focuses include examining how a protein tail on microtubules might control different features of a cell. Hough noted that, in addition to being a confi- dence-booster, the Webb-Waring Biomedical Research Award he received in 2014 allowed him to move forward with research that might be considered high-risk. “It worked great and that WRITTEN BY research is the foundation for the rest of what JEANNE MC ADARA, PH D we’re doing now,” he said.

18 BIOSCIENCECOLORADO // 2019-2020 Photo credit Glenn Asakawa/University of Colorado

Boettcher Investigator Robin Dowell says Boettcher Scholars have been a valuable addition to her lab.

Hough also takes advantage of another unique aspect of Boettcher Foundation funding: the ability to have undergraduate Boettcher Scholars work in his lab. Boettcher Scholarships are awarded to 42 outstanding Colorado high-school graduates each year, allowing them to attend college in Colorado. “They’re all really good,” Hough said of the Boettcher Scholars who have worked in his lab. “Having that connection to a high-quality pool of undergraduates and the money to do work with them is a real benefit.” 2010 Boettcher Investigator Robin Dowell, an associate professor of molecular, cellular and developmental biology whose computational biology work examines gene transcription, has eagerly welcomed Boettcher Scholars into her lab as well.

“I haven’t had direct Boettcher funding in several years but having these under- grads in my lab has had an impact that is almost more valuable,” she said. Dowell added that another benefit of her Boettcher funding was the opportunity it gave her to engage with the Colorado BioScience Association and the small business sector of the bioscience community. That encouraged her to launch her own business utilizing her research methods for other companies, an outcome she called an “unintended side effect” of her Webb-Waring Award. Dowell’s experience as a Boettcher Investigator prompted her to encourage her colleague, Edward Chuong, to apply for the program. Chuong, a genome

2019-2020 // BIOSCIENCECOLORADO 19 Photo credit Glenn Asakawa/University of Colorado

biologist whose research focuses on finding the Boettcher Investigators Loren Hough (above) and Edward Chuong (below) both round out causes of gene dysregulation, was named a 2018 their research teams with undergraduate Boettcher Scholars. Boettcher Investigator. “Having the Boettcher award made starting the lab a lot easier. I was able to focus on setting up the lab the way I wanted without skimping on equipment,” said Chuong, an assistant professor of molecular, cellular and developmental biology. “We are doing our first experiments, moving along a lot faster than I would have expected. Having a talented Boettcher Scholar in the lab has also been a great help.” In addition to Boettcher Investigators and Boettcher Scholars crossing paths at BioFrontiers, the facility represents yet another aspect of Boettcher Foundation funding. As a supporter of nonprofits that are developing the next generation of leaders, the Boettcher Foundation provides grants to many organizations throughout Colorado. The foundation awarded a grant toward the completion of the BioFrontiers facility in 2014. “To see our Boettcher Investigators, our Boettcher Scholars, our higher education partners and our grant funding come together in a single place is absolutely inspiring,” said Katie Kramer, President and CEO of the Boettcher Foundation. For more information on the Boettcher Foundation, please visit www.BoettcherFoundation.org. Photo credit Glenn Asakawa/University of Colorado

20 BIOSCIENCECOLORADO // 2019-2020 WRITTEN BY JEANNEJEANNE MC ADARA,ADARA P H D

ACCORDING TO THE U.S. CENTERS FOR DISEASE CONTROL 100 persons in 2017, respectively), many of and Prevention, more than 135 million Americans Colorado’s counties have some of the highest visit emergency departments (EDs) annually, for opioid prescribing rates in the United States, help with everything from traumatic accidents with some generating prescription volumes in to headaches. Regardless of etiology, pain and excess of one per member of its population. discomfort are the most common presentations “Aside from a few bad actors in so-called pill mills, in the ED, but all pain is not created equal, and physicians for the most part just want to alleviate decisions regarding how to treat it are coming pain and suffering. And to the xe tent that physi- under increasin g scrutiny in the face of a raging, cians are people like everyone ele se, we see the nationwide epidemic o f opioid abuse. In news, and how things have ramped up over the Colorado, opioid-related fatalities have become years, and we have started looking at our own more common than deaths from alcohol-r e- role in this crisis.” lated traffic accidents and have continued to rise over the past five years. While Colorado’s That’s according to Heidi Wald MD, MSPH, cur- opioid prescribing rates are below the national rently the Chief Quality and Safety Officer for SCL average (about 53 versus 59 prescriptions per Health, a faith-based, nonprofit healthcare organization headquartered in Broomfm ield, Colorado.

2019-2020 // BIOSCIENCECOLORADO 21 Both at SCL Health and in her previous role as pain—headache, unspecified abdominal pain, EDs are a physically contained environment, with physician-advisor to the Colorado Hospital long bone fracture, musculoskeletal/low back a defined population of patients, doctors, nurses, Association (CHA; Greenwood Village, Colorado), pain, and kidney stones. The goal was to reduce pharmacists, and therefore a great place to pilot Wald has been part of an important statewide, opioid prescriptions by 16%. these ideas.” multi-organization, public-private, collaborative “And it worked really well,” says Tad-y. “We saw Robert Valuck, PhD, RPh is the director of the initiative to address the opioid epidemic, starting an average 36% reduction in opioid prescriptions Colorado Consortium for Prescription Drug in Colorado hospital EDs. in the first six months of the pilot, with a corre- Abuse Prevention (“the Consortium;” head- The initiative, which has been jointly led by the sponding 31% increase in the administration of quartered within the Skaggs School of Pharmacy CHA and its numerous partners, is called the ALTOs.” With such compelling initial results, the and Pharmaceutical Sciences at the University Colorado ALTO (Alternatives to Opioids) Project. project is now undergoing a planned expansion of Colorado Anschutz Medical Campus, Aurora, Its goal is to change opioid-prescribing patterns to eventually include all Colorado EDs. Colorado). He says that, while the ED-focused at EDs throughout the state, by implementing A key advantage of the program, in Wald’s view, is Colorado ALTO Project is aimed at reducing acute pain-management and prescribing guidelines that it is peer-driven, with guidelines developed prescribing to opioid-naïve patients, its initial developed by the Colorado chapter and ongoing success has, as hoped, of the American College of Emergency attracted attention from other spe- Physicians (CO-ACEP; Northglenn). cialties outside the ED. His organiza- The guidelines and training are tion, along with the Colorado Medical aimed at redirecting how ED physi- Society (CMS; Denver, Colorado), have cians, nurses, pharmacists, and other now partnered with CHA for a new staff think about pain management; phase of the collaboration, the CO’s instead of choosing opioids first, CURE initiative. This project is aimed evidence-based pathways present at reducing opioid administration in treatments that, in many cases, have the inpatient setting by extending the been proven to be more effective and program’s learnings to subspecialties safer in specific situations. Examples like surgery, urology, and family and include combination acetaminophen by and for prescribers in specific sub-specialties. hospital medicine. and ibuprofen for headaches, migraine-specific Since announcing the successful results from the “This is an important piece,” says Valuck. “It’s eas- medications, and lidocaine trigger-point injec- pilot, the Colorado ALTO project has been able to iest to stop opioid use disorders by not exposing tion or patches for musculoskeletal pain. recruit more than 85% of Colorado’s hospital and people in the first place, but chronic pain is still “A critical message of the guidelines and the project freestanding EDs to be trained in the approach. challenging. Patients are understandably afraid is that we are not telling prescribers to ignore pain, “It speaks to what state-wide collaboration can of not having their pain controlled and of with- or to never use opioids for any situation,” says bring especially when backed by opinion of a pro- drawal, so we have a lot more work to do.” Darlene Tad-y MD, current physician-advisor to fessional society.” In fact, she says, SCL Health’s Tad-y says that the CO’s CURE initiative and other CHA. “The message is, there are many proven, active participation in the broader rollout programs coming out of this collaboration are successful alternatives for acute pain that we includes reaching into Montana for peer-to-peer built on a new understanding of the role of harm should try first. We want to treat pain effectively education and program recruitment. reduction in managing opioid use disorders. “The and ALTOs are a good way to do that.” All involved acknowledge that EDs hold sway critical pillars to getting a hold on this crisis are: The ALTO Project was piloted in 10 EDs throughout over just a tiny segment of the opioid prescribing limit opioid prescriptions, use alternatives when the state in 2017 and concentrated on pain milieu, but as Wald says, “you can’t boil the possible, reduce the stigma of addiction, and management for the five top presentations of ocean. You have to start with a scope-able project. actively treat addiction.”

22 BIOSCIENCECOLORADO // 2019-2020 Of course, there remains much more to be done. Based on decades of experience in the public sphere, Valuck also sees a key role for the private sector in the crisis. “After seeing all the things that have been done well so far, academia, policy, and money still can’t fix every problem or solve every need,” he says. “There are still issues that doctors, patients, and law enforcement struggle with on the ground.” That gap spurred Valuck to found the digital health company OpiSafe™ (Denver, Colorado), which has produced a suite of apps aimed at helping doctors prescribe according to best practices, monitor patterns of use in individual patients, and notice red flags for early detection and intervention. “Opioid use disorder shows up as a complex con- stellation of behaviors and signals,” says Valuck. “Doctors can identify the pattern if they can see it. OpiSafe shows them all the data points.” OpiSafe also offers an app for law enforcement and the lay public, OpiRescue™, to help guide untrained bystanders in how to manage a potential overdose victim while waiting for medical first responders to arrive. It’s likely that software and machine learning will play an increasing role in curbing opioid Be Brilliant. For 30 years, we’ve helped clients move ideas from the napkin into production.

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2019-2020 // BIOSCIENCECOLORADO 23 24 BIOSCIENCECOLORADO // 2019-2020 Your spaces shape your ideas. Shi-Long Lu adapts a sound MOA ARCHITECTURE can help you design a flexible, efficient, and approach to noninvasive testing productive home for your big ideas to grow. for head and neck cancer

When Shi-Long Lu, MD, PhD, Associate Professor of Otolaryngology at University of Colorado Anschutz Medical Campus, encountered a good solution to a major clinical challenge, it stuck with him. “As a postdoc, I contributed For more information, reach out to our to research that led to an Science + Technology Director Brian Konczak FDA-approved, noninvasive test for col- at [email protected]. Architecture | Interiors orectal cancer, Cologuard®,” he says. “After I switched my research focus to head and neck cancers, I realized I could use a similar prescribing and connecting patients to coordi- company is actively seeking collaborations for approach there.” nated care in the coming years. Other companies signal studies in other clinical areas. That idea led to a saliva-based test called to watch in this area include RxRevu™ (Denver, “The most significant feedback from people who’ve HNKlear. The test, which detects specific Colorado), which provides prescription deci- used our device is not necessarily, ‘you’ve reduced modifications to tumor DNA, is now in clin- sion support to prescribers at the point of my pain.’ Instead it’s ‘I feel freedom of choice and ical trials in collaboration with John Song, care, and Julota® (Colorado Springs, Colorado), control,’” says Hanbury. “In the moment of a pain MD, at University of Colorado Anschutz which enables secure sharing of health and spike, patients can choose to use a device instead Medical Campus. So far, the data is prom- personal information with a broad array of of popping a pill that may help but interfere with ising, and Lu is hopeful that one day the test community-based services. other activities or put them at risk. We view the could be used for routine screening. Another approach to providing alternatives to mask as a tool in the toolbox to give people “It’s my dream to see something I came up opioids for pain management is being explored more control and freedom over how they want with used in the clinic,” Lu says. “That’s a by Sana Health, Inc. (Lafayette, Colorado). The to manage their pain in the moment.” true sign that your work is valuable.” company was named after the capital city of Yemen, where in 1992, founder and CEO Richard If HNKlear proves capable of early detection, Hanbury suffered a crippling spinal injury with it stands to drastically improve outcomes for such severe nerve damage that he was not head and neck cancers. Only 40 to 50 percent expected to live more than 5 years—a slow death of patients survive 5 years. from neuropathic pain so overwhelming and Lu’s determination to do novel, important intractable that he would eventually die from the work is what made him a cancer researcher. inability to experience restorative sleep. Opioids were the first line of treatment, but because “I started out as just a clinician, but I quit of the natural build-up of physiological drug to start a research lab because I wanted to tolerance they quickly lost effect. Grasping for figure out things that no one yet understood.” anything to help, Hanbury happened to notice Lu established a company, SummitDX, to that certain audiovisual stimulation could dis- refine and advance HNKlear. The company tract him from his pain, and based on his back- The opioid epidemic is complex and the chal- is supported by CU Innovations’ SPARK ground and an interest in neurobiology was able lenges many. These efforts are in relative program, which focuses on technologies to invent a new form of audio-visual brainwave infancy and require refinement and extension. addressing unmet clinical needs to bridge entrainment to cure his neuropathic pain quickly. What all of the participants seem to agree on is the “translational gap” between the lab Now, after 27 years and a number of technical that Colorado’s cultural focus on collaboration bench and the patient. As a SPARK pro- and financial hurdles, Sana Health’s noninva- and innovation is already positioning the state gram fellow, Lu was paired with world-class sive, biotherapeutic mask is in early trials. The as a national model for addressing an over- industry counsel, and Lu’s advisor has an first completed study in opioid use disorder whelming puzzle. especially relevant background. showed the Sana device halved subjective opi- “SPARK connected me with Stan Lapidus, who oid-withdrawal symptoms compared to sham, Valuck says, “Colorado is demonstrating to the developed Cologuard® as the founder and CEO and reduced every other symptom measured. nation that we’re not waiting until the problem of Exact Sciences,” Lu remarks. “With his advice, Planned future studies include neuropathic worsens to do something. We’re working together I know we’re headed in the right direction.” pain, fibromyalgia, and oncology pain, and the and taking charge now.”

2019-2020 // BIOSCIENCECOLORADO 25 26 BIOSCIENCECOLORADO // 2019-2020 2019-2020 // BIOSCIENCECOLORADO 27 THE GROWTH AND SUCCESS OF COLORADO’S stage capital and create a strong ecosystem that LIFE SCIENCE ECOSYSTEM would not be as robust increases the state’s global competitiveness. as it is today without valuable assistance from The AI Grant program supports innovators the state’s Advanced Industries (AI) Accelerator and creates jobs. Colorado’s economy, our Grant Program. Initiated in 2006, and known as bioscience companies, and the patients our the Bioscience Discovery Evaluation Grant Pro- companies serve all benefit from these critical gram (BDEG), Colorado recognized the need to investments. Since its inception, the state’s AI support the development of its novel technolo- Accelerator Grant Program has awarded 413 gies and make an effort to advance commercial- grants to bioscience companies, creating 79 ization. The program’s success led to the passage new companies, 773 direct jobs, and $551.7 of additional legislation in 2013, enacting the AI million in follow-on grants and investments. Accelerator Grant Program we know today. In addition, the AI Export Grant Program sup- The AI Accelerator Grant Program promotes growth ports many small and medium-sized busi- and sustainability in Colorado’s seven advanced nesses in the advanced industries, and off- industries – advanced manufacturing, aerospace, sets international business development and bioscience, electronics, energy, infrastructure engi- related marketing costs. These programs exem- neering and technology – by helping drive inno- plify the importance of investment to promote vation, accelerate commercialization, encourage growth and sustainability to drive innovation, public-private partnerships, increase access to early accelerate commercialization and encourage public-private partnerships.

28 BIOSCIENCECOLORADO // 2019-2020 Delivering high-quality medications developed speciﬁcally for pediatric patients www.silvergatepharma.com

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2019-2020 // BIOSCIENCECOLORADO 29 30 BIOSCIENCECOLORADO // 2019-2020

COMPANY NAME INVESTOR COMPANY NAME DEAL VALUE (US$M) DEAL TYPE ANNOUNCED DATE INDUSTRY 3DBiopsy, Inc. Undisclosed 0.85 Venture Financing 27-Aug-18 Medical Devices Ampio Pharmaceuticals, Inc. Undisclosed 8 Equity Offerings 9-Aug-18 Pharma ArcherDx, Inc. Boulder Ventures, Ltd. 35 Venture Financing 20-Mar-18 Medical Devices Peierls Foundation, Inc. Longwood Fund Management, LLC PBM Capital Group, LLC Boulder Ventures, Ltd. Peierls Foundation, Inc. Armis Biopharma, Inc. Undisclosed 1.83 Venture Financing 22-Jun-18 Pharma Array BioPharma, Inc. Undisclosed 125 Equity Offerings 9-May-18 Pharma Articulus Bio, LLC Undisclosed Venture Financing 2-Jan-18 Medical Devices Asius Technologies, LLC Undisclosed 0.2 Venture Financing 13-Feb-18 Medical Devices Aspero Medical, Inc. Innosphere Fund Private Equity 19-Jul-18 Medical Devices Aytu BioScience, Inc. Armistice Capital, LLC 5 Equity Offerings 5-Nov-18 Pharma Aytu BioScience, Inc. Undisclosed 15.2 Equity Offerings 5-Oct-18 Pharma Aytu BioScience, Inc. Undisclosed 12 Equity Offerings 1-Mar-18 Pharma Biodesix, Inc. Undisclosed Venture Financing 5-Mar-18 Pharma Biodesix, Inc. Undisclosed 5.3 Venture Financing 10-May-18 Pharma Biodesix, Inc. Undisclosed 17.5 Venture Financing 10-Oct-18 Pharma Biodesix, Inc. Undisclosed 1.5 Venture Financing 23-Feb-18 Pharma Brava Diagnostics Undisclosed 4 Equity Offerings 20-Nov-18 Medical Devices Cell>Point, LLC Undisclosed 5 Venture Financing 4-Oct-18 Medical Devices CeraPedics, Inc. KCK Group 22 Venture Financing 13-Jul-18 Medical Devices Cerebral Therapeutics, Inc. Vivo Capital, LLC 3 Venture Financing 20-Jun-18 Medical Devices Granite Point Capital Management, L.P. Cerebral Therapeutics, Inc. Granite Point Capital Management, L.P. 3 Venture Financing 20-Jun-18 Pharma Vivo Capital, LLC Certa Dose, Inc. Undisclosed 2.6 Venture Financing 2-Jul-18 Medical Devices Certa Dose, Inc. Undisclosed 0.05 Venture Financing 3-Jan-18 Medical Devices Clovis Oncology, Inc. Undisclosed 100 Equity Offerings 16-Apr-18 Pharma Clovis Oncology, Inc. Undisclosed 300 Debt Offerings 16-Apr-18 Pharma Concentric Undisclosed 9.5 Venture Financing 8-Jan-18 Ag Bio Concentric Undisclosed 15.9 Venture Financing 19-Apr-18 Ag Bio DMC Biotechnologies Undisclosed 1.75 Equity Offerings 10-Jan-18 Biotech DMC Biotechnologies Undisclosed Venture Financing 3-Oct-18 Biotech EIR, Inc. (HeartHero) Undisclosed 2.02 Venture Financing 17-Jul-18 Medical Devices Encision, Inc. CMED Partners LLLP 0.35 Equity Offerings 20-Dec-18 Medical Devices Eximis Surgical, LLC Questa Capital Management, LLC 7.5 Venture Financing 8-Nov-18 Medical Devices Venture Investors, LLC Eximis Surgical, LLC Undisclosed 5.15 Venture Financing 15-Feb-18 Medical Devices

32 BIOSCIENCECOLORADO // 2019-2020 Pharma Intelligence Center ŝƐƚŚĞůĞĂĚŝŶŐĨƵůůǇŝŶƚĞŐƌĂƚĞĚ ŽŶůŝŶĞƉůĂƚĨŽƌŵ͕ƉƌŽǀŝĚŝŶŐƵŶƉĂƌĂůůĞůĞĚĚĂƚĂĂŶĚŝŶƐŝŐŚƚƐ ƚŚĂƚŵĞĞƚǇŽƵƌŝŶĚŝǀŝĚƵĂůďƵƐŝŶĞƐƐŶĞĞĚƐ News Company Database Database Deals Drugs Databases Database Database ŽŵƉůĞƚĞĐŽǀĞƌĂŐĞŽĨƉŝƉĞůŝŶĞĂŶĚŵĂƌŬĞƚĞĚĚƌƵŐƐ Net Present Site & Investigator ŽŵƉƌĞŚĞŶƐŝǀĞĐůŝŶŝĐĂůƚƌŝĂůƐŝŶƚĞůůŝŐĞŶĐĞĐŽǀĞƌŝŶŐƚƌŝĂůƐ͕ƐŝƚĞƐ͕ Value (NPV) Databases ŝŶǀĞƐƚŝŐĂƚŽƌƐ͕ĂŶĚĞŶƌŽůůŵĞŶƚĚĂƚĂŐůŽďĂůůǇĨŽƌĂůůŝŶĚŝĐĂƚŝŽŶƐ 'ůŽďĂůĐŽǀĞƌĂŐĞŽĨĐŽŵƉĂŶŝĞƐ͕ŶĞǁƐ͕ĂŶĚĚĞĂůƐ Clinical Trials Financial Database Analytics Pharma Specialty disease experts /Ed>>/'E /ŶͲĚĞƉƚŚĨŽƌĞĐĂƐƚĂŶĚĂŶĂůǇƐŝƐĨŽƌϭϮϬнŚŝŐŚůǇƉƌĞǀĂůĞŶƚĂŶĚ EdZ Enrollment Data ĞŵĞƌŐŝŶŐ͕ƌĂƌĞĂŶĚŶŝĐŚĞĚŝƐĞĂƐĞƐ Drug Insights & Analytics Commercial epidemiology Outsourcing WĂƚŝĞŶƚͲďĂƐĞĚĨŽƌĞĐĂƐƚŝŶŐŵŽĚĞůƚŽĚĞƚĞƌŵŝŶĞƚŚĞŵĂƌŬĞƚƐŝǌĞ Insights Feasibility ĨŽƌƚŚĞƌĂƉĞƵƚŝĐŝŶĚŝĐĂƚŝŽŶƐ Planner

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2019-2020 // BIOSCIENCECOLORADO 33 COMPANY NAME INVESTOR COMPANY NAME DEAL VALUE (US$M) DEAL TYPE ANNOUNCED DATE INDUSTRY Flagship Biosciences, Inc. Undisclosed 1 Venture Financing 9-Jan-18 Pharma Flagship Biosciences, Inc. Undisclosed Venture Financing 10-Jul-18 Pharma Flagship Biosciences, Inc. Undisclosed 2.5 Venture Financing 26-Jun-18 Pharma Inscripta, Inc. Foresite Capital Management, LLC 30 Venture Financing 19-Dec-18 Pharma Merieux Developement MLS Capital Fund NanoDimension Management Limited Paladin Capital Group Venrock Healthcare Capital Partners, LP Inscripta, Inc. Foresite Capital Management, LLC 55.5 Venture Financing 28-Feb-18 Pharma MLS Capital Fund II NanoDimension Management Limited Paladin Capital Group Venrock, Inc. Machavert Undisclosed 2 Venture Financing 8-Feb-18 Pharma Pharmaceuticals, LLC mBio Diagnostics, Inc. Heska Corp 6 Venture Financing 21-Aug-18 Medical Devices Undisclosed mBio Diagnostics, Inc. Undisclosed 1.1 Venture Financing 9-May-18 Medical Devices MedAware Systems, Inc. Undisclosed 0.15 Venture Financing 15-Jan-18 Pharma miRagen Therapeutics, Inc. Undisclosed 38.5 Equity Offerings 8-Feb-18 Pharma Neuraptive Therapeutics Undisclosed 11.5 Equity Offerings 19-Dec-18 Medical Devices Neuraptive Therapeutics, Inc. New Rhein Healthcare Investors, LLC 14 Venture Financing 18-Dec-18 Pharma Neuraptive Therapeutics, Inc. Undisclosed 0.1 Venture Financing 2-Aug-18 Pharma Ocugen, Inc. Undisclosed 5 Venture Financing 1-Feb-18 Pharma OnKure, Inc. Delian Capital 7 Venture Financing 2-May-18 Pharma Rezolute, Inc. BVF Partners, LP 4 Private Equity 2-Apr-18 Pharma Rezolute, Inc. Lincoln Park Capital Fund, LLC 11.78 Equity Offerings 29-Jan-18 Pharma Rezolute, Inc. BVF Partners, LP 0.7 Private Equity 29-Jan-18 Pharma SomaLogic, Inc. Undisclosed 0.15 Venture Financing 18-Jan-18 Medical Devices SomaLogic, Inc. Undisclosed 0.15 Venture Financing 18-Jan-18 Pharma SomaLogic, Inc. iCarbonX Co, Ltd 200 Private Equity 3-Jan-18 Pharma Madryn Asset Management, LP Nan Fung Life Sciences Sopris Health Access Venture Partners 3.4 Venture Financing 2-Oct-18 Digital Health Cue Capital Tallwave Capital Cedars-Sinai Accelerator Techstars Rockies Venture Fund Triple Endoscopy, Inc. Undisclosed 0.5 Venture Financing 23-Feb-18 Medical Devices Viveve Medical, Inc. Undisclosed 20 Equity Offerings 6-Dec-18 Medical Devices Viveve Medical, Inc. Undisclosed 34.5 Equity Offerings 7-Feb-18 Medical Devices

34 BIOSCIENCECOLORADO // 2019-2020 ORGANIZATION AWARDS FUNDING ORGANIZATION AWARDS FUNDING Ablelink Technologies, Inc. 1 $17,171 National Jewish Health 74 $49,257,961 Access Sensor Technologies, LLC 1 $500,451 Native American Cancer Initiatives, Inc. 1 $499,535 Aerophase, Inc. 1 $150,000 Op-T-Mune, Inc. 1 $561,109 African Strategies/Advancing Pathology 1 $38,120 Phoenix NMR, LLC 1 $223,461 Allander Biotechnologies, LLC 2 $1,498,912 Point Designs, LLC 1 $224,952 American Association Of Neuropathologists, Inc. 1 $22,300 Pueblo Department of 1 $70,000 Public Health and Environment Amidebio, LLC 1 $207,286 QalibreMD, Inc. 1 $224,422 Aspirebio Corporation 1 $225,000 Rocky Mountain Virology Association 1 $8,500 Aurora Oncology, Inc. 1 $299,937 Sharklet Technologies, Inc. 1 $805,971 Bcell Solutions, Inc. 1 $292,177 Sivec Biotechnologies, LLC 1 $293,142 Biological Sciences Curriculum Study 1 $263,837 TDA Research, Inc. 3 $1,080,091 Biomimetix Jv, LLC 1 $300,000 TopoGen, Inc. 1 $256,100 Boulder County Public Health Department 1 $70,000 University Corp for Atmospheric Research 1 $11,644 Boulder Nonlinear Systems, Inc. 1 $693,539 University of Colorado 154 $59,302,981 CHI Institute for Research & Innovation 1 $1,051,535 University of Colorado at Colorado Springs 2 $864,000 Clearsight, LLC 1 $499,999 University of Colorado Denver 774 $265,320,056 Colorado Alphaherpesvirus Latency Society 1 $45,000 University of Denver (Colorado Seminary) 19 $6,232,502 Colorado Cancer Research Program, Inc. 1 $842,762 Ursa Analytics, Inc. 1 $222,381 Colorado Research Partners, LLC 1 $769,627 VA Eastern Colorado Health Care System 39 $- Colorado School of Mines 6 $2,542,116 Verifax Corporation 1 $150,000 Colorado State Department/Agriculture 3 $1,216,262 VetDC, Inc. 1 $150,000 Colorado State Dept/Pub Health & Environment 9 $2,073,294 Visugen Global, LLC 1 $149,998 Colorado State University 123 $34,385,977 Wavi Company 1 $222,838 Crestone, Inc. 1 $2,575,997 Z Biotech, LLC 1 $149,935 Denver Health and Hospital Authority 10 $3,384,863 Denver Museum of Nature and Science 1 $255,880 Dream Face Technologies, LLC 1 $241,344 Fieldline, Inc. 1 $219,167 Fischer Imaging, Inc. 1 $299,950 Fort Lewis College 2 $359,992 Immunomolecular Therapeutics, LLC 1 $224,991 Keystone Symposia 43 $409,000 Klein Buendel, Inc. 10 $4,703,990 Kromatid, Inc. 1 $206,597 Lifeboard Medical 1 $150,000 Lohocla Research Corporation 1 $1,500,000 MBC Pharma, Inc. 3 $1,291,054 Meadowlark Optics, Inc. 1 $1,258,442 Menogenix, Inc. 1 $693,360 Mesa County Health Department 1 $69,779 National Environmental Health Association 2 $1,022,750

2019-2020 // BIOSCIENCECOLORADO 35 36 BIOSCIENCECOLORADO // 2019-2020 C = CBSA MEMBER

MED TECH C Agilent Technologies Arcturus Star Products, LLP Boulder, Frederick Cortez C 3D Systems - Healthcare www.agilent.com www.lymphstarpro.com Littleton Provides core electronic and bio-analytical Pioneering Vibrational Energy Therapy for the www.3dsystems.com measurement tools to advance life science wellness and beauty professions. Therapeutic Produces highly accurate 3-D physical research. Commercial manufacturing of nucleic specialty is in the area of lymphatic health. models of human bone structure acid active pharmaceutical ingredients. from imaging such as CT or MRI. Arthroventions C AktiVax Denver C 3DBiopsy, LLC Broomfield www.arthroventions.com Vail www.aktivax.com Developing a family of devices that www.3dbiopsy.com Developing novel reconstitution safety distend the synovial fluid to improve Developed a complete turnkey biopsy syringes for vaccines and biologics. the accuracy of aspirating and injecting system that uses three dimensional (3D) medication into the joint space. imaging to map the entire prostate gland Alligant Scientific and identifies any clinically significant Highlands Ranch C Articulus Bio cancer with up to 95% accuracy. alligantscientific.com Boulder Developing new approaches to www.articulusbio.com 5280 Prosthetics socially relevant technical problems Articulus Bio, LLC is a development-stage Littleton in energy and materials science. orthopedic medical device platform www.5280prosthetics.com focused on total joint replacement. 5280 hypobarric socket technology C Allison Medical increases tissue profusion, physiologically Littleton ASI Medical, Inc. improving limb health. www.allisonmedical.com Centennial Develops a variety of disposable products which www.asimedical.net Abilities Unlimited serve the healthcare needs of retail/pharmacy, Developer of specialized mobile and integrated Colorado Springs, Denver acute, alternate, and home care markets. dental carts, as well as unique dental www.auiop.com instruments for the modern dental office. Provides artificial limbs and custom C AlloSource orthopedic appliances. Centennial Aspero Medical www.allosource.org Boulder Ablacon Develops, processes and distributes life- www.asperomedical.com Wheat Ridge enhancing bone and tissue allografts Developing an endoscopic device that www.ablacon.com to the medical community. can be used by doctors treating patients Ablacon works to improve catheter with gastrointestinal diseases. technologies in order to make the AFib ablation AllPro procedures safer and more efficient: Sensing Broomfield C Aspire Biotech, Inc. catheters allow to better control the catheter www.allprodental.com Colorado Springs positioning and intensity of the ablation. Produces a large selection of non-latex prophy www.aspirebiotech.com cups, prophy angles and other dental products. Provides contract services for all phases Access Sensor Technologies of product development from concept C Apdyne Medical Company Fort Collins to launch, and produces its own skin Denver www.accsensors.com sealant and wound-closure adhesives. Paper-based diagnostics for industrial and www.apdyne.com personal environmental monitoring. Manufactures and distributes the Apdyne Auri-Stim Medical Phenol Applicator Kit used to anesthetize Denver Acertara Acoustic Laboratories, LLC the tympanic membrane during www.net1device.com Longmont in-office myringotomy procedures. Offers an alternative therapy for migraine www.acertaralabs.com headaches, hormonal migraine, chronic AQ Biomed Independent ISO/IEC accredited medical headaches, premenstrual syndrome Boulder ultrasound acoustic measurement (PMS), nicotine and narcotics addictions www.aqbiomed.com and testing laboratory. using the NET-1000 device. AQ BioMed has made new discoveries about Aestis, Inc. how cells respond to chemical interactions Bard Medical Boulder and physical forces caused by biomedical Louisville www.altitudetraining.com/aux/about/aestis implants. AQ’s first program is the AQ www.crbard.com Develops a treatment for obesity through shunt, uniquely designed to control over- Leading multinational developer, controlled hypoxia technology. The two pressurization inside the eye caused by manufacturer and marketer of innovative, principal components are the air separation glaucoma and prevent the onset of blindness. life-enhancing medical technologies in unit and proprietary control system. the fields of vascular, urology, oncology Archer DX and surgical specialty products. AF Therapeutics (AFTx, Inc.) Boulder Westminster www.archerdx.com Beckman Coulter Phase Synchronization mapping provides Creates catalog and custom next-generation Loveland infinite spatial resolution mapping sequencing (NGS) assays that are purpose- www.beckmancoulter.com of Atrial Fibrillation with an ordinary built to identify mutations and gene Develops and produces instruments loop (Lasso or Spiral HD) catheter. fusions from clinical sample types. for the diagnostic industry. Specializes in the fields of immunocytochemistry, AFT ArcScan, Inc. flow cytometry, and microbiology. Longmont Golden www.aftmim.com www.arcscan.com Bell Dental Products, LLC Customized metal injection components. Developing VHF Ultrasound for Englewood comprehensive ophthalmic imaging. www.belldental.com Designs, develops, and manufactures precision dental equipment based on electric motor technology.

2018-2019 // BIOSCIENCECOLORADO 37 BioCare Systems, Inc. C Brava Diagnostics C ClaroLabs Parker Boulder Lafayette www.lumiwave.com www.bravadx.com www.clarolabs.com Designs, develops and markets the FDA- Brava Diagnostics is developing and will ClaroLabs is a Mass Spectrometry Lab cleared LumiWave that uses deep-tissue commercialize rapid diagnostic products specialized in measuring drugs in biological light therapy to decrease pain, accelerate for the acute care market, based on the fluids for toxicology and medication healing and improve quality of life. MBio Diagnostics technology platform. compliance testing for pain, and primary care The first IVD applications are for cardiac practices. The company offers full clinical C Biodesix, Inc. markers, a $2.3 billion worldwide market. chemistry and Pharmacogenetic testing. Boulder Our multiplex point-of-care tests will be www.biodesix.com Clean Room Devices, LLC used to assess chest pain and shortness of Develops and commercializes blood-based Westminster breath in the emergency department. The tests that advance the speed and standard www.cleanroomdevices.com next assays will address sepsis, the highest of care in oncology. Its diagnostics help Manufactures products that are engineered cost disease state in U.S. health systems. patients and their doctors make more specifically for “clean room” environments. informed decisions about treatment based Broadwest Corporation C ClearSight on a patient’s unique molecular profile. Boulder Aurora www.broadwest.com C Biomaterial Device Innovations, LLC www.clearsight.io Develops and manufactures ergonomic Colorado Springs Developing an intraocular lens to give mammography viewing equipment. www.biomaterialdevices.com ophthalmologists a comprehensive solution The company is focused upon Canberra Industries to reduce posterior capsule opacification. commercialization of implantable Arvada The ClearSight IOL features Sharklet, a bioresorbable medical devices based www.canberra.com micropattern designed to redirect cellular upon proprietary technology. Manufactures and supplies analytical migration away from the field of vision. instruments, systems and services for radiation BioVision Technologies CME detection and radiation monitoring. Golden Golden www.biovisiontech.com CardioNXT www.cmeamerica.com Develops and manufactures micro-visualization Westminster Manufactures ambulatory infusion devices. solutions that enable endoluminal and www.cardionxt.com Cochlear Americas minimally invasive medical procedures Developing a portfolio of technologies that Centennial in both human and veterinary medicine. enable the delivery of therapy more accurately www.cochlearamericas.com The imaging technologies and customized and cost effectively in catheter ablation Global leader in implantable hearing micro-endoscope solutions are integrated procedures to treat cardiac arrhythmia. solutions. Manufacturer of Nucleus to reduce incision size and speed healing. Care Electronics, Inc. cochlear implants and the Baha BodySync, Inc. Broomfield programmable bone conduction system. Aurora www.medicalshoponline.com C Colibri Heart Valve www.bodysync.com Offers a range of electronic monitoring Broomfield Applies evidence-based genetic information and alarm equipment for the home www.colibrihv.com to develop personalized products that help health and long term care markets. Researches and develops novel individuals achieve their health goals. Car-May, LLC heart valve technologies. C Bolder Surgical Berthoud Colorado Precision Products, Inc. Louisville www.car-may.com Boulder www.justrightsurgical.com Provides pumping capability, fluid www.coloradoprecision.com Developing precisely designed surgical measurement, and flow control Provides diamond turned and polished instruments that allow access to confined all in one compact module. optics/ parts. Fabricator of X-ray telescope spaces and often delicate structures. C Cerapedics optical components. Produces and offers air Boulder Innovation Group Westminster bearing LVDT contact linear measurement Boulder www.cerapedics.com systems, .05 microinch resolution. www.boulderinnovators.com Developing and commercializing novel C Colorado Therapeutics Develops and manufactures image-guided osteobiologic products based on a Broomfield surgical navigation digitizers and industrial proprietary small peptide technology, www.co-therapeutics.com 3D capture and modeling equipment. P-15™ on anorganic bone mineral (ABM). Developing xenogenic biologic tissue C Boulder iQ C CereScan matrix products for a broad range of Boulder Littleton soft tissue reinforcement, regenerative, www.boulderiq.com www.cerescan.com and additional applications. Boulder iQ is an expert contract consulting Combines brain imaging technologies with a C ConMed Corporation firm offering design engineering, development patient-centered model of care to provide the Centennial and turnkey manufacturing for consumer, highest level of neurodiagnostics available. www.conmed.com high-technology and medical products, Certa Dose Designs and manufactures RF electrosurgical and complete regulatory, clinical, and Denver generators and accessories of the highest quality management system services for the www.certadose.com quality, safety and value for use in surgical medical device and in-vitro diagnostic (IVD) Unique measuring system that helps eliminate procedures performed in virtually every industries. The company is ISO 13485:2016 dosing errors in pediatric patients. hospital, surgery center and physician’s office. certified through Boulder BioMed.

38 BIOSCIENCECOLORADO // 2018-2019 C = CBSA MEMBER

Connexall Die Cut Technologies Eleven P15 Boulder Northglenn Aurora www.connexall.com www.diecuttech.com Diagnostic biotech company enabling Enterprise-grade event management Offers precision material conversion, early diagnosis and treatment of and control platform that delivers skilled assembly and manufacturing idiopathic pulmonary fibrosis. hospital-wide interoperability to efficiencies, including cleanroom facilities. C Ellab, Inc. people, systems, tasks, and devices. Diversatek Healthcare Denver CoorsTek Highlands Ranch www.ellab.com Golden www.diversatekhealthcare.com Ellab manufactures wireless, real-time data www.coorstek.com Designs, manufactures and loggers and wired thermocouple validation Custom engineering, materials expertise, distributes diagnostic products systems with temperature, humidity, operational excellence, and rapid execution. focused on gastroenterology. pressure, vacuum, conductivity and CO2 sensor options. Ellab also offers on-site CoramiR Biomedical DNTLworks Equipment Corporation qualification, validation and calibration Superior Centennial services for thermal validation processes www.coramir.com www.dntlworks.com ranging from -196°C to 400°C. Environments Developing non-invasive biomarker Manufactures portable, mobile and often include freezers, incubators, stability tests to guide treatment decisions self-contained dental systems. chambers, autoclaves, and ovens. in heart-failure patients. Double Black Imaging Encision, Inc. Corgenix Medical Corporation Westminster Boulder Broomfield www.doubleblackimaging.com www.encision.com www.corgenix.com Manufactures clinical review monitors Designs and manufactures innovative surgical The Colorado facility is engaged in research, that are specially designed for versatile devices. Developed AEM® Laparoscopic development, manufacture, and marketing clinical healthcare applications. Instruments to improve electrosurgery of in vitro diagnostic products for use in C Double Helix and reduce the chance for patient injury disease detection and prevention. Boulder in minimally invasive surgery. Corvectra, Inc. www.doublehelixoptics.com C EndoShape, Inc. Fort Collins Develops and commercializes computational Boulder, Aurora www.corvectra.com optical-digital technologies used in range www.endoshape.com Developing clinical tools that enable healthcare estimation, super-resolution microscopy and Manufactures surgical and medical instruments professionals to non-invasively diagnose and 3D imaging. Double Helix’s core technologies focusing on shape memory polymer treat patients with a single point of care device. include the Double Helix-Point Spread Function devices for endolumenal application. method for 3D super-resolution imaging. Cuattro C enlightenVue Loveland dpiX, Inc. Denver www.cuattro.com Colorado Springs www.enlightenvue.com Flat panel digital radiography systems www.dpix.com Specializes in bringing micro-endoscope that improve efficiency and workflow, Produces high-resolution amorphous silicon technology to the medical device market by increase productivity and lower costs. (a-Si) sensor arrays for medical X-ray imaging. innovating low-cost disposable alternatives. DataWave Technologies Corporation E.I. Medical Imaging Euvive, LLC Loveland Loveland Aurora www.dwavetech.com www.eimedical.com Euvive strives to provide affordable point- Manufactures a wireless and battery-free Manufacturer of highly portable and ruggedized of-care (POC) biomedical diagnostic device for acquiring and transmitting data from ultrasound devices for the veterinary industry. systems through collaborative work of electrodes and other biosensors to a receiver Edgeport Surgical seasoned scientists and engineers. placed meters away for electrophysiology, Boulder neurophysiology and physiology related C Evergreen Research, Inc. Medical product development research on both humans and large animals. Golden and investment company. www.evergreenresearch.com C dBMEDx EJ BioMed - A Division of Eldon James BE BRILLIANT™ Your “One-Stop-Shop” Littleton Corporation for medical device design, approval & www.dbmedx.com Denver manufacturing. Mechanics, electronics, Developing next-generation, automated, www.eldonjames.com software, fluidics, optics, ultrasound, RF & wireless 3D ultrasound devices. Manufactures, assembles and packages sterile disposables for hospital, emergency Denver Optic Company PVC Free tubing and connectors in a & home healthcare settings. Evergreen Englewood single cleanroom environment. Research provides engineering, regulatory www.eyeprosthetics.com affairs, quality systems,production & Electronic Materials, Inc. (EMI) Specializes in the fitting and fabrication distribution with experienced personnel Breckenridge of two types of ocular prosthesis. to make it happen, all the way. www.emiuv.com DePuy Synthes, Companies of Johnson & Offers a complete line of EMCAST UV adhesives, C Eximis Surgical, Inc. Johnson epoxies, sealants, encapsulants and coatings. Louisville Monument EMI also offers room temperature, thermal www.eximissurgical.com www.synthes.com and Visible light cure adhesive systems. Developing a novel surgical platform for the Develops, produces and markets instruments, safe and fast removal of large specimens Element implants and biomaterials for the surgical through small laparoscopic/robotic incisions. Longmont fixation, correction and regeneration of www.element.com the human skeleton and its soft tissues. Medical device testing laboratory specializing Desert Glass Works in package testing, accelerated aging, Colorado Springs photostability, UV, temperature/humidity, www.dgw.com vibration, shock testing services. Manufactures quartzware for the medical and research industries.

2018-2019 // BIOSCIENCECOLORADO 39 Extreme Diagnostics C ForCast Orthopedics Hach Company Boulder Longmont Loveland www.extremediagnostics.com www.forcastortho.com www.hach.com Develops noninvasive measurement Focused on improving total joint patient Manufactures and distributes analytical systems, including optical systems such as care, ForCast Orthopedics will incorporate instruments and reagents used to test the custom holographic and interferometric antibiotic reservoir and novel infusion quality of water and other aqueous solutions. instruments. Specializes in structural system within a total new prosthesis to C HeartHero health monitoring, nondestructive replicate improved patient outcomes Denver testing, and materials processing. with simpler pain management. hearthero.io Falcon Rehabilitation Products Galaxy Ophthalmics Developing automated external defibrillator. Denver Denver HG Medical Technologies www.falconrehab.net/products www.galaxyophthalmics.com Fort Collins Designs and builds high quality, innovative Developing technologies related to new hgmedtech.com quadriplegic seating systems and accessories therapies for Glaucoma, Wet and Dry Macular Startup in medical device development. (Falcon Rehabilitation Products, LaBac Degeneration and Diabetic Retinopathy. Seating Systems, Gel Ovations). Hirsh Precision Products, Inc. gaugewear Boulder Firefly Medical, Inc. Boulder www.hirshprecisionproducts.com Fort Collins www.gaugewear.com Manufactures precision-machined www.fireflymedicalinc.com Using radiometric thermometry, gaugewear and assembled components Designs and develops innovative is creating a wearable, non-invasive, for the medical industry. durable medical equipment for core body temperature sensor. clinical healthcare markets. Impressio, Inc. Genesee BioMedical, Inc. Aurora Fischer Imaging Denver www.impressio.tech Wheat Ridge www.geneseebiomedical.com Impressio focuses on developing liquid- www.fischerimaging.com Manufactures cardiac surgery crystalline elastomers (LCEs) for use in Fischer Imaging is focused on improving instruments and devices. load-bearing orthopedic applications such outcomes for cancer patients with advanced Genovus Biotechnologies, Inc. as knee and total disk replacement. imaging. Our proprietary technology Louisville doubles the resolution and contrast of InDevR, Inc. www.enovusbiotech.com today’s mammography using less than Boulder Develops biophysical medicine-based half the x-ray dose and removes the www.indevr.com treatments for neuromuscular conditions. need for painful breast compression. Develops and manufactures biomedical Its lead developmental product is a instruments including molecular diagnostic Fischer Medical non-invasive, neuromodulating medical assays, virus measurement systems and Wheat Ridge device for the treatment of functional detection technologies for micro-arrays. www.fischermti.com symptoms of multiple sclerosis. Designs, manufactures, and markets Infinity Laboratories Gnathodontics, Ltd. cardiac and otolaryngology devices. Castle Rock Lakewood www.infinitylaboratories.com FlashBack Technologies www.gnatho.com Infinity Laboratories operates from a 25,000+ sq Longmont Specializes in functional dentistry, ft state-of-the-art facility. With enhanced focus www.flashbacktechnologies.com advanced implant work, precision in the areas of chemical and microbiological Fast, non-invasive detection of acute blood partial dentures, combination cases sciences we support manufacturers and loss volume and prediction of cardiovascular and metal-free fixed restorations. researchers throughout the world. collapse in emergency situations. C Green Sun Medical Infinity Photo-Optical Company Fluonic Fort Collins Centennial Boulder www.greensunmedical.com www.infinity-usa.com www.fluonic.com Develops innovative treatments to address Manufactures long-distance and Develops infusion therapy systems Adolescent Idiopathic Scoliosis (AIS) continuously-focusable microscope with disposable sensors for OEM and through non-fusion scoliosis solutions. technology, macro systems, internal- proprietary pumping systems. Groesanoak Product Development, Inc. focusing devices and other lenses. C Footbeat Frederick Instec, Inc. Grand Junction www.groesanoak.com Boulder www.footbeat.com Creates innovative proprietary new www.instec.com Footbeat has fundamentally changed medical devices focusing on areas of Manufactures precision temperature medical and athletic recovery through its injury management, neonatal care controllers and microscope hot stage systems unique method of circulatory enhancement. and performance monitoring. for temperature cycling, food sciences, By applying precise, cyclic pressure to C Guided Surgical Solutions materials characterization, forensics, polymers the arch of the foot, Footbeat increases Denver and liquid crystals and microbiology. blood velocity to alleviate the symptoms of www.guidedsurgicalsolutions.com common medical conditions and enhance Intelligent Imaging Innovations (3i) Guided Surgical Solutions utilizes state of athlete’s ability to prepare, repair, and Denver the art software & 3D printing technology recover for their sport. Footbeat is easy- www.intelligent-imaging.com to ensure a more safe, accurate, and to-use, non-invasive, and ideal for travel. Designs and builds systems around the newest efficient surgery. Surgical outcome is automated fluorescence microscopes and more predictable for follow-up treatment the most advanced peripheral devices. resulting in the best possible aesthetic and functional results for your patient.

40 BIOSCIENCECOLORADO // 2018-2019 C = CBSA MEMBER

Katharos C MD MedTech, LLC Microlife Medical Home Solutions, Inc. Aurora Englewood Golden A medical device used in patients during www.mdmedtech.com www.mimhs.com hemodialysis to remove phosphates Developer and manufacturer of medical Proprietary hand-held medical devices that lead to high rates of cardiovascular ultrasound imaging components and finished and systemic solutions offer healthcare disease and death in this population. devices for traditional and custom applications. providers evidence-based and practice-tested methods for accurate C Kestrel Labs, Inc. Med-Botics assessment, diagnosis, and treatment of Boulder Colorado Springs cardiovascular and metabolic diseases. www.kestrellabs.com www.med-botics.com Combines internal research and development Development of medical devices for prevention C Mighty Oak Medical projects with consulting and contract of apnea, hypoxemia, and overdose from Englewood development of innovative patient monitoring medication causing respiratory depression. www.mightyoakmedical.com concepts and other medical technologies. Develops cutting-edge spinal C Medtronic technologies for use in spine surgery. Lenox MacLaren Surgical Instruments Boulder, Louisville Louisville www.medtronic.com Mikron Corporation www.lenoxmaclaren.com Together, with our partners in the healthcare Englewood Manufactures precision orthopedic and industry, we are committed to developing www.mikron.com neurological surgical instruments. meaningful innovations. Medtronic has ~2,400 Supplies transfer machining systems employees in Colorado who develop life- for complex parts, cutting tools with Lifeboard changing medical technologies and solutions high performance standards, self Fort Collins such as surgical robotics, energy based surgical medication and diagnostic devices. Device that captures, displays and instruments, respiratory and patient monitoring records all essential data during Mile High Ophthalmics solutions, interventional lasers, computer- time-critical medical events. Aurora based diagnostic & surgical visualization Ophthalmic device for enhanced Liquid Logic tools, and surgical imaging technologies. precision in cataract surgery. Aurora Let’s take healthcare Further, Together. www.liquid-logic.com Mind Studios Mesa Laboratories, Inc. Developed a proprietary “digital microfluidics” Colorado Springs Lakewood technology based on electrowetting that A full service product design and research www.mesalabs.com precisely manipulates small droplets studio housed within the University of Provides dialysis meters and related within a sealed disposable cartridge to Colorado at Colorado Springs. Offers supplies to dialysis clinics world wide. perform complex laboratory protocols. concept generation, advanced prototyping, Metabiomics engineering and consumer research, human C LivaNova Aurora factors design and manufacturing solutions. Arvada www.metabiomics.com www.livanova.com NEBA Health, LLC Developing a non-invasive microbiome test Global medical device company and a leader Boulder for the earlier and more accurate detection in the treatment of cardiovascular diseases. www.nebahealth.com of colon polyps and colorectal cancer. Also Develops neuropsychiatric medical Logisens Corporation developing services for characterizing devices, such as Neba™, an experimental, Fort Collins gut microbiome health and disease. small format EEG-based device being www.logisens.com Metamatrix, LLC studied under an IDE from the FDA. Develops biosensor and software technology, Boulder enabling a significant breakthrough in realtime Neuro Assessment Systems www.zorbent.com measurement and reduction of stress. Littleton Manufacturers of ZORBENT, an absorbent www.neuroassessments.com Lumed designed to leave no residue, reducing Provides an objective brain-based measure Denver the risk associated with slippery of neurocognitive symptoms associated with www.lumedscience.com surfaces. It is completely safe to use a wide range of brain health issues including Specializes in creating medical and dental and represents no health hazard. concussion and Alzheimer’s disease. devices that integrate light sources to C MFB Fertility, Inc. improve visibility in the field of work. Neuromonics, Inc. Boulder Westminster Magnelab, Inc. www.mfbfertility.com www.neuromonics.com Longmont Commercializing an in vitro diagnostic Manufactures and distributes clinically www.magnelab.com allowing couples to track hormone cycling proven devices to treat tinnitus. The Manufactures custom magnetic components involved in the ovulation process and Sanctuary provides situational relief for those (transformers/inductors) for the medical field. track when a female is most fertile. suffering from mild to moderate tinnitus. Mallinda, LLC Micro Imaging Solutions, LLC Nova Biolabs Aurora Denver Arvada www.mallinda.com www.micro-imaging.us www.novabiolabs.com Advancing the state of polymer with the Developed an innovative, patented technology Nova Biolab’s core mission is to make development of the first hard plastic that can be utilized in the manufacture molecular testing standard of care. We are that can be repeatedly molded and of micro-digital CMOS cameras. focusing on targeted NGS assays based on reshaped at mild temperatures. liquid biopsies (e.g., blood, urine) for cancer C MBio Diagnostics diagnosis, treatment and post-recovery Boulder monitoring, as a cost-effective and minimally www.mbiodx.com invasive means to get patients on the right Develops a low-cost, high sensitivity, treatment path as soon as possible. multipathogen detection system for diagnostics.

2018-2019 // BIOSCIENCECOLORADO 41 nSpire Health, Inc. Peak Analysis & Automation Ltd. Prescott’s, Inc. Longmont Colorado Springs Monument www.nspirehealth.com www.paa-automation.com www.surgicalmicroscopes.com Develops, manufactures and markets Manufactures robots, special equipment, Provides reconditioned operating microscopes respiratory care products and services and turnkey automated systems for a and allied accessories that function as intended focused on cardiopulmonary diagnostics, variety of industries including: biotech, by the original equipment manufacturer. respiratory core lab services, and electronics, medical, semiconductor, etc. C Prima-Temp, Inc. disease management solutions. Peddle Master, Inc. Boulder C OptiEnz Sensors Johnstown www.prima-temp.com Fort Collins www.peddlemaster.com Innovative biometric approaches to www.optienz.com Designs and manufactures handicapped early disease detection and reproductive Revolutionizing measurement capabilities driving aids. The Peddle Master is totally medicine through the application for organic chemical concentrations in portable and can be installed and of 21st century thermometry. aqueous solutions; now providing continuous, removed in a matter of seconds. Products Group International, Inc. real-time, in-place sensor systems. Pernicka Corporation Lyons C Orbit Genomics Fort Collins www.productsgroup.com Boulder www.pernicka.com Researches, develops and engineers ultrasound www.orbitgenomics.com Offers analytical testing that meets or medical and veterinary equipment. Orbit Genomics™, Inc. is an early stage exceeds the requirements of MIL-STD Propel Labs, Inc. genomics company developing diagnostic tests 750/883 method 1018 and 45662A. Fort Collins and services based on repetitive sequences in C PharmaJet, Inc. www.propel-labs.com DNA, known as microsatellites. Microsatellites Golden Designing the next generation of occur throughout the genome in both coding www.pharmajet.com bio-instrumentation tools. Focused and non-coding regions and they mutate Developer of needle-free jet injection on research tools, such as single 10,000 times more rapidly than SNPs and other technology, optimized for vaccine cell analyzers and cell sorters. genetic mutations, representing both inherited administration, with two device platforms and and acquired risk. The company’s first product ProTechSure Scientific, Inc. regulatory clearance for all three tissue depths. will be a lung cancer risk assessment test. Aurora C Phase Three Product Development www.protechsure.com C Orthomi, LLC Fort Collins Dedicated to providing scientifically Boulder www.phasethreedev.com validated skin protection. www.jortek.com Technology and product development of Orthomi develops novel orthopedic Protomed, Inc. microfluidics based devices and systems. devices primarily in the sports medicine Denver market. The primary objective is Philips www.protomed.net preservation and restoration of patient’s Colorado Springs Creates accurate anatomical models musculoskeletal system through medical, www.philips.com from CT scans by using the latest imaging surgical, and rehabilitative means. Develops, manufactures, markets and software and laser driven technology. distributes single-use medical devices C Osypka Medtec, Inc. Prototype Casting, Inc. used in minimally invasive procedures Longmont Denver within the cardiovascular system. www.osypka-medtec.com www.protcast.com Works with medical device manufacturers Point Designs Manufactures non-ferrous prototype parts and suppliers to manufacture innovative, Louisville for the medical industry, specializes in quality product solutions or components www.pointdesignsllc.com RPM (Rubber Plaster Mold) casting, sand for companies around the United States. Point Designs strives to innovate in the casting and rapid investment casting. field of upper limb prosthetics. Oval Window Audio QalibreMD Nederland Porta-Lung, Inc. Boulder www.ovalwindowaudio.com Lakewood www.qalibre-md.com Produces induction loop assistive www.portalung.com Provides design engineering and listening systems and visual and Provides non-invasive ventilator support for manufacturing services for custom vibrotactile technologies that help deaf long-term patients who need more portability. instrumentation development. Commercialized and hard of hearing individuals. a line of quantitative MRI phantoms for Precision Biopsy standardization of scanners and protocols Paragon 28 Aurora involved in precision medicine. Englewood www.precisionbiopsy.com www.paragon28.com In partnership with Allied Minds, developing Quadric Biomed, LLC Addressing the unmet and under-served technology for the accurate diagnosis Colorado Springs needs of the foot and ankle market segment. of prostate cancer which uses advanced www.quadricbiomed.com spectroscopy imaging techniques in Quadric BioMed, LLC is a medical device PARÉ Solutions, LLC combination with tissue biopsy. company developing novel dental implants Centennial that mimic the emergence profile of www.paresurgicalsolutions.com Preferred Medical Products, Inc. natural teeth. Quadric BioMed’s patented Develops surgical instruments such as the Englewood implant system integrates an eccentrically- Quik-Stitch endoscopic suturing system. www.preferredmedicalproducts.com shaped platform and anchor screw in Manufactures stainless steel medical Parker Medical the jaw and is the only technology that components for hypodermic needles Highlands Ranch can anatomically match the profile of the and lancet type products. www.parkermedical.com teeth as they emerge from the bone. Provides airway management products that make intubation safer for the patient and easier for the medical professional.

42 BIOSCIENCECOLORADO // 2018-2019 C = CBSA MEMBER

QuSpin, Inc. Scientech, Inc. C SomaLogic, Inc. Louisville Boulder Boulder www.quspin.com www.scientech-inc.com www.somalogic.com Develops very high performance Manufactures analytical instruments: Uses aptamer array technology and atomic sensors. semi-micro balances, analytical balances, bioinformatics capabilities to discover semi-analytical balances, and toploading disease-specific biomarkers and Radiological Imaging Technology, Inc. balances for the medical industry. protein signatures. Develops medical Colorado Springs diagnostics based on these signatures. www.radimage.com C Securisyn Medical Provides clinical and research physicists Highlands Ranch Sonaura with a high precision automated QA tool www.securisyn.com Fort Collins for advanced radiation therapies. Developing a safer system for www.mysonaura.com delivering life-sustaining oxygen to Developed an electronic two way Rand-Scot, Inc. mechanically ventilated patients. communication system between patient and Fort Collins doctor, which represents a major advance in www.randscot.com Shape Ophthalmics, LLC IVF treatment allowing women undergoing Designs and manufactures products for Aurora IVF treatment to perform their sonograms at persons with disabilities including BBD Develops state of the art devices and novel home during the follicle stimulation cycle. Cushions and Mattress Overlays, EasyPivot treatments for ophthalmic conditions through Patient Lifts, and Saratoga Exercise Products. the application of advanced smart materials. Sound Surgical Technologies, LLC/Solta Medical, Inc. Research Electro-Optics C Sharklet Technologies, Inc. Louisville Boulder Aurora www.vaser.com www.reoinc.com www.sharklet.com Offers ultrasonic technologies and related Volume manufacturer of high precision thin Engineers surface technologies (Sharklet™) that techniques for aesthetic surgery. film coatings, optics and optomechanical controls the growth of dangerous bacteria. assemblies for the ultraviolet ST Cardio Technologies, LLC C Shippert Medical Technologies an Innovia through the long-wave infrared. Broomfield Medical Company Designs, develops, and manufactures Rocky Mountain Instrument Company (RMI) Centennial electronic medical devices for use in Lafayette www.shippertmedical.com electrophysiology cardiac cath labs. www.rmico.com Manufactures and distributes medical Designs and manufactures optics disposable products and instruments. St. Renatus, LLC and coatings (ultraviolet through far Fort Collins Sinopsys Surgical infrared) for the medical industry. www.st-renatus.com Boulder First needle-free, dental anesthetic suitable for Rocky Mountain Orthodontics, Inc. (RMO) www.sinopsyssurgical.com use in procedures involving most of the upper Denver Lacrimal Sinus Diversion offers functional teeth. Uses an accurate and sophisticated www.rmortho.com therapy for sufferers of chronic sinusitis method to anesthetize the upper teeth Serves all areas of orthodontics including with minimal response to current without the risk and pain of a needle. pediatric orthodontic prevention, pharmaceutical and surgical options. interceptive pediatric orthodontics, mixed StnDrd Infusion C SI-Technology, LLC dentition orthodontics, adult orthodontics, Parker Fort Collins reconstructive dentistry orthodontics, TMJ www.stndrdinfusion.com www.si-technology.co orthodontics, surgical orthodontics and Early-stage medical device company in the Orthopedic medical device company breathing/sleep problem related orthodontics. drug infusion market with a standardized developing new techniques and implants pump capable of performing the product Sapien, LLC as part of the patent pending SI-DESIS™ requirements currently met by syringe, Fort Collins Sacroiliac Joint Implant System to help assist cassette, and ambulatory pump configurations. www.sapienllc.com physicians address the need for treatment, Aims to enhance the human experience fixation and proper fusion of painful and Stryker Sports Medicine by providing innovative solutions dysfunctional sacroiliac joints (SIJ). Greenwood Village to human problems using sensory www.stryker.com C Snoasis Medical substitution, human-machine interfaces, Stryker’s Sports Medicine business Denver and human-machine integration. delivers a wide range of innovative sports www.snoasismedical.com medicine implants, instrumentation, C Sapphire Technology, LLC Focused on the development and resection and biologic solutions. Denver commercialization of regenerative www.sapphire-technology.com tissue and medical device products Suez The SGS Instrument line is developed for use in dental surgery. Boulder specifically to overcome the inherent www.geinstruments.com C SoftRay, Inc. composite adhesion and pullback issues Manufactures instruments used Fort Collins associated with other composite instruments to measure total organic carbon www.softraybiodetection.com currently at market in the dental field. (TOC) in water for pharmaceutical SoftRay develops, licenses, and manufactures applications and medical research. Sartorius systems for the detection of microorganisms for Arvada industrial applications requiring sterile fluids as SummitDx www.sartorius.us well as for blood products. Currently developing Aurora Designs and manufacturers analytical a product for the detection of biocontamination Developed a saliva-based molecular balances, electrochemistry instruments, of blood platelet donations prior to transfusion. test for head and neck cancer. moisture analyzers, and titration controllers. Solo-Dex Sundance Diagnostics, Inc. Science Care Boulder Boulder Denver www.solo-dex.com www.sundancedx.com www.sciencecare.com Developed the Fascile, which allows Working to develop the world’s Provides human tissue for medical for a continuous peripheral nerve first genetic safety tests to predict a research and education. block in less than 5 minutes. patient’s risk of antidepressant-induced suicidal thinking or behavior.

2018-2019 // BIOSCIENCECOLORADO 43 Sunrise Medical, Inc. TeraBAT Triple Endoscopy Longmont Longmont Aurora www.sunrisemedical.com www.terabat.com Modified a medical endoscopic technique Provides home healthcare products including Developing a disruptive detection for pediatric and created a new multi-use wheelchairs, respiratory, daily living aids, platform based on terawaves endoscope for use in pediatrics and adults. and speech augmentation devices. technologies that will revolutionize C TriSalus Life Sciences disease diagnosis and patient care. Supreme Cable Technologies, Inc. Westminster Denver C Terumo BCT www.trisaluslifesci.com www.supremecable.com Lakewood Developing advanced liver cancer infusion Manufactures quality custom cable www.terumobct.com systems that overcome the limitations of assemblies and wire harnesses. A global leader in blood component and traditional tools and delivery methods. cellular technologies, it is the only company C Surgical Coatings, LLC TRS, Inc. with the unique combination of apheresis Sedalia Boulder collections, manual and automated whole www.surgicalcoatings.com www.trsprosthetics.com blood processing, and pathogen reduction Surgical Coatings develops and applies Develops, manufactures, and markets body- coupled with leading technologies in advanced coatings onto medical devices. powered prosthetic devices. Designs and therapeutic apheresis and cell processing. The purpose of the coatings applied include builds technology for persons missing hands. insulation, lubricity, abrasion resistance TheraTogs, Inc. Ultrathera Technologies, Inc. and a multitude of other customer needs. Telluride Colorado Springs www.theratogs.com SurgiReal Products www.ultrathera.com Produces an orthotic undergarment and Fort Collins Applying advanced technologies strapping system that gives clients with www.surgireal.com to physiological and neurological sensorimotor impairment a new modality for Creates and introduces innovative products needs. Maker of GyroStim™. improving postural alignment and stability. and methods for surgical training. C Vaporox Thinklabs Medical, LLC Swan Valley Medical, Inc. Denver Centennial Aurora www.vaporox.com www.thinklabs.com www.swanvalleymedical.com Vaporox, Inc. was formed to commercialize Creates digital stethescopes, including Developed a line of urology instruments that Vaporous Hyperoxia Therapy (VHT™), a One, the smallest, most powerful allow for safer, faster, and more economical patented and FDA-510K-cleared technology that stethescope in the world. treatment of common urological disorders. represents a breakthrough in treating 7 different Thrombo Therapeutics types of skin wounds, including diabetic foot Symbios Technologies, Inc. Aurora ulcers (DFUs) and pressure ulcers (bed sores). Fort Collins Developing diagnostic tools to help assess www.symbiosplasma.com Veramarx, Inc. treatments for traumatic bleeding. Commercializing an aqueous plasma Aurora disinfection and advanced oxidation Tissue Fusion www.veramarx.com technology platform with applications Colorado Springs Focus to become the leading provider of in fluid purification, plasma medicine, Surgically fuses tissues together using laser credible clinical and scientific information, and specialty manufacturing to improve energy instead of staples or sutures. reliable and accurate diagnostic tools and human and environmental health as well effective treatment options for Lyme disease. Touch of Life Technologies, Inc. (ToLTech) as the economics and sustainability of food Aurora Vista LifeSciences and beverage, agricultural, energy, and www.toltech.net Parker pharmaceutical production processes. Develops procedural simulators in the www.vistalifesciences.com Tapeless Wound Care Products, LLC areas of orthopedics, gastroenterology, Innovative healthcare technology solutions Englewood rheumatology, radiology, ophthalmology, for global healthcare challenges. Manufactures and distributes a system and general surgical procedures. Vitan-Biotech, LLC of patented secondary wound dressing C Trans1 Aurora retention devices, offering an alternative North Carolina www.vitan-biotech.com to traditional secondary wound dressings, www.trans1.com Specializes in the development and for both humans and animals. Seeks to develop and commercialize commercialization of life science Tartan Orthopedics, Ltd. elegant and minimally-invasive surgical instrumentation, novel biosensing Northglenn solutions to address spinal pathologies. systems and diagnostic devices. www.tartanortho.com Transtracheal Systems, Inc. WalkMed, LLC Manufactures sacro lumbar belts, dorsal Englewood Aurora lumbar belts (corsets and moldable www.tto2.com www.walkmed.com inserts), Ottenberg style elbow splint, pelvic Develops and manufactures innovative Offers solutions for ambulatory infusion traction belts, arm slings, cervical collars, respiratory therapy products that advance therapy and pain management. acromioclavicular splints, and ankle supports. medical therapy for persons requiring Wi Medical Device Development TDA Research, Inc. continuous supplemental oxygen, including the Englewood Wheat Ridge, Golden SCOOP transtracheal oxygen therapy system. www.wiinc.net www.tda.com C Transverse Medical, Inc. Designs and engineers medical Provides automated catalyst testing Evergreen devices, including innovative services equipment to large chemical companies www.transversemedical.com such as laser welding, assay design, and national laboratories. Developing the POINT-GUARD ™ and air bubble management. Embolic Protection System for cerebral and distal embolic protection during cardiovascular percutaneous interventions and surgical procedures.

44 BIOSCIENCECOLORADO // 2018-2019 C = CBSA MEMBER

C Zimmer Biomet Spine C AmideBio, LLC C Atlas Biologicals, Inc. Broomfield Boulder Fort Collins www.zimmerbiomet.com www.amidebio.com www.atlasbio.com Leading medical device manufacturers, Zimmer Focused on providing peptide and Manufacture, market and distribute and Biomet, join to offer innovative orthopedic protein research reagents and clinical animal sera and cell culture reagents. medical devices and joint replacement. products for a diverse array of research Aurora Oncology and commercial targets using proprietary Zynex Medical, Inc. Aurora Biopure-Process™ technology. Englewood www.auroraoncology.com www.zynexmed.com AMP Disovery Aurora Oncology is developing drugs to Offers electrotherapy products, utilizing Aurora treat superficial bladder cancer and to various methods of non-invasive muscle Therapeutics company focused on treat drug resistant bacterial infections. stimulation and electromyography technology, developing novel antimicrobial treatments Avidity, LLC Interferential Current (IFC) and Transcutaneous for gram-negative pathogens. Aurora Electrical Nerve Stimulation (TENS). C Ampio Pharmaceuticals, Inc. www.avidity.com Englewood Develops and sells molecular affinity www.ampiopharma.com tools for connecting molecules. BIOTECH, PHARMA & RELATED Development-stage biopharmaceutical C AxImmune company focused on the discovery and C AbbVie Fort Collins development of novel therapies aimed at Texas www.aximmune.com treating common inflammatory conditions for www.abbvie.com We put all of our energy and experience which there are limited treatment options. Combines advanced science with expertise to into being your partner of choice. We create make strides in drug and treatment discovery. ApopLogic Pharmaceuticals, LLC value for customers through manufacturing ADA Technologies, Inc. Aurora excellence, reliable quality and innovative Littleton www.apoplogic.com science. Our people are the experts that www.adatech.com Focused on the discovery, development, and our customers enjoy working with. commercialization of therapeutic products Development and commercialization C Aytu BioScience that target apoptotic cell death pathways of innovative technologies. Englewood found in cancers, leukemias and lymphomas. Aerophase, Inc. www.aytubio.com C Longmont Apspida Biosciences We truly offer our customers an end-to-end Aerophase Inc is a specialty pharmaceutical Denver partnership for the research, development and company that is leading the effort to Virtual biotech proof of concept company. manufacture of small molecule therapeutics at every stage of the drug lifecycle. treat lung cancer with drugs delivered C ARCA Biopharma, Inc. as aerosols directly into the lungs. Broomfield, Aurora C BCell Solutions, Inc. C Agilent Technologies www.arcabiopharma.com Colorado Springs Boulder, Frederick Specializes in developing and commercializing Established to further research and www.agilent.com genetically-targeted therapies for heart develop a new drug therapy for the Develops and manufactures failure and other cardiovascular diseases. various forms of autoimmune diseases, neurodegenerative diseases, and cancer. therapeutic oligonucleotides. Armis Biopharma C C Allander Biotechnologies Fort Collins Biogen Aurora www.armisbiopharma.com Massachusetts www.allanderbiotech.com Armis Biopharma is a late-stage clinical www.biogen.com Developing novel therapeutics biopharmaceutical company with a growing Biogen discovers, develops, and delivers for oral mucositis. pipeline of targeted anti-infective therapeutics worldwide innovative therapies for designed to address antibiotic resistance people living with serious neurological Allergan, Inc. and healthcare-associated infections, a and neurodegenerative diseases. Highlands Ranch serious and rapidly growing phenomenon. www.allergan.com Biomimetix JV, LLC C Multi-specialty health care company Arpeggio Biosciences Englewood focused on discovering, developing and Boulder www.biomimetixpharma.com commercializing innovative pharmaceuticals, www.arpeggiobiosciences.com A biopharmaceutical corporation developing biologics, medical devices and over- Arpeggio Biosciences leverages state of the art compounds for the treatment of various the-counter consumer products. sequencing approaches coupled to powerful disease and health care treatment machine learning to uncover novel insights into classifications such as radiation toxicity Allergy Solutions a compound’s biological mechanism of action. incurred during the treatment of cancer. Erie C C www.symbiaallergy.com Array Biopharma BioPlx Symbia offers a system, to organize, Boulder, Longmont Boulder streamline and simplify the delivery www.arraybiopharma.com www.bioplx.com of allergy care for non-allergists. Discovers, develops and commercializes BioPlx is an advanced microbiomics company targeted small molecule drugs to developing non-antibiotic methods for the American Allied Biochemical, Inc. treat debilitating and life-threatening control of infectious disease, including multiple- Centennial diseases such as cancer. drug resistant “super-bugs”. The company www.aablabs.com employs targeted microbiological agents C Atara Biotherapeutics Specializes in the purification and distribution along with nutrient, and signaling factors to Aurora of restriction endonucleases enzymes. create unique and protectable formulations. www.atarabio.com C Amgen, Inc. Focused on developing meaningful therapies C BioResponse, LLC California for patients with severe and life-threatening Boulder www.amgen.com diseases. Product candidates: (a) allogeneic www.bioresponse.com Discovers, develops, manufactures and or third-party derived antigen-specific T-cells, Researches, develops and commercializes markets human therapeutics based on and (b) molecularly targeted biologics. dietary supplements for better advances in cellular and molecular biology. absorption and functional foods.

2018-2019 // BIOSCIENCECOLORADO 45 BioServe Space Technologies C CBL Biopharma Colorado Biolabs, Inc. Boulder Boulder Frederick www.colorado.edu/engineering/BioServe www.cblbiopharma.com www.proferrin.com Specializes in conducting microgravity Offering peptide starting materials, peptide Manufactures an oral iron supplement life science research and designing and intermediates, and industrial and commercial- made from heme iron polypeptide (HIP). developing space flight hardware. scale manufacturing of proprietary and Our proprietary process results in an oral generic GMP and non-GMP peptides. iron product that provides an optimal C Bolder BioTechnology, Inc. amount of HIP in a single tablet. Boulder Cell>Point www.bolderbio.com Centennial C Colorado Histo-Prep (CH-P) Bolder BioTechnology is a clinical stage www.cellpointweb.com Fort Collins protein engineering company dedicated to Develops novel radiopharmaceutical www.histoprep.com providing patients with easier to use, safer, and imaging agents, radiotherapeutic agents Produces high quality slides, clinical chemistry more cost effective protein pharmaceuticals and local regional radio/chemotherapeutic and hematology data and fully integrated for the treatment of their disease. drug delivery systems for the diagnosis, and detailed seamless pathology reports. treatment and post therapy assessment of C Bond Pets Colorado Research Partners cancer, cardiovascular disease, infectious Aurora Aurora disease and metabolic diseases. www.bondpets.com Developing novel drugs that block In a process similar to craft brewing, we start Cerebral Therapeutics the effects of sugar, including sugar with live cells from an animal (no slaughter Aurora craving, and sugar-induced obesity, required) and feed them a nutrient-rich www.cerebraltherapeutics.com hypertension, fatty liver and diabetes. broth of vitamins and minerals. The same Combines advanced micro-dosing C Colorado Serum Company ones an animal would eat on farm and technology with proprietary medications Denver field, only without the pharmaceuticals. to precisely deliver treatments to the www.thepeakofquality.com other side of the blood-brain barrier Boulder Scientific Company Supplies veterinary biologic vaccines, to improve the lives of patients with Mead instruments, laboratory reagents and uncontrolled neurological disease. www.bouldersci.com serums for the veterinary industry. Provides organometallic compounds Cerecin C Corden Pharma to the pharmaceutical, polymer, and Denver, Singapore Boulder specialty chemical industries. www.cerecin.com www.cordenpharmacolorado.com Cerecin is a global healthcare company with C Brickell Biotech, Inc. Corden Pharma Colorado is the small to almost 20 year of innovation and leadership in Boulder largescale resource for peptides manufacturing. brain health and target conditions ranging from www.brickellbio.com memory impairment to neurological diseases. C Crestone, Inc. A clinical-stage pharmaceutical company Boulder focused on the development of innovative C Cetya Therapeutics, Inc. www.crestonepharma.com and differentiated therapeutics for Fort Collins Drug discovery and development company the treatment of skin diseases. www.cetyatherapeutics.com focused on developing novel treatments Commercializes analogs of the class I isoform C Bristol-Myers Squibb for serious bacterial infections. selective histone deacetylase inhibitor (HDACi) New York largazole, targeting unmet medical needs, Cytoskeleton, Inc. www.bms.com especially in oncology, neurodegeneration, Denver A global BioPharma company firmly autoimmunity, and hemoglobinopathies. www.cytoskeleton.com focused on its mission to discover, Offers kits for drug screening, signal develop and deliver innovative medicines CHATA Biosystems transduction and cytoskeletal research to patients with serious diseases. Fort Collins specializing in the production of purified www.chatasolutions.com C Cambrex proteins and easy-to-use kits to study Manufactures blended reagents, Longmont biochemical and cellular processes. HPLC mobile phases, standards, www.cambrex.com buffers and dissolution media. C Dicerna Pharmaceuticals Cambrex is the leading small molecule company Massachusetts that provides drug substance, drug product Click Nucleic Acids, Inc. www.dicerna.com and analytical services across the entire drug Boulder Dicerna Pharmaceuticals, Inc., is a lifecycle. Driven by passion, our pharmaceutical www.clicknainc.com biopharmaceutical company focused products, expertise and technologies Combining thiol-ene-based click on the discovery and development of accelerate our customers’ small molecule chemistry and oligonucleotide synthesis RNAi-based therapeutics for diseases therapeutics into markets across the world. to produce a new class of oligonucleotide involving the liver, including rare diseases, and polynucleotide derivatives. C Care Research, LLC viral infectious diseases, chronic liver Fort Collins C ClinImmune Labs diseases, and cardiovascular diseases. www.careresearchll.com Aurora C DMC We offer a wide variety of animal models www.clinimmune.com Boulder from rodents, rabbits, dogs, guinea pigs, Comprises five laboratories to provide www.dmcbio.com farm pigs, mini pigs, sheep, goats, horses services to kidney, heart, lung, pancreas, DMC engineers microbes for the production of and cattle and a single point of control in our and hematopoietic stem cell transplant a broad diversity of high-value products with study directors for a full range of studies. programs around the world. development costs and timelines that are more CariCord C Clovis Oncology, Inc. than 100x improved over the state of the art. Aurora Boulder C Edgewise Therapeutics www.caricord.com www.clovisoncology.com Boulder Processing and storage of umbilical Focused on acquiring, developing Edgewise Therapeutics is a biotechnology cord blood & stem cell products and commercializing innovative anti- company focused on developing novel available, anywhere in the world. cancer agents in the U.S., Europe and therapies for diseases involving skeletal muscle. additional international markets.

46 BIOSCIENCECOLORADO // 2018-2019 C = CBSA MEMBER

C Editas Medicine C Genentech Hiberna Corporation Boulder, Massachusetts California Boulder www.editasmedicine.com www.gene.com Pursuing the potential clinical application Editas Medicine is building the leading Using human genetic information to discover, of hibernation in order to slow metabolism, genome editing company dedicated to treating develop, manufacture and commercialize thereby extending survival limits in patients with genetically defined diseases. medicines to treat patients with serious traumas that reduce oxygen to certain or life-threatening medical conditions. cells, e.g. in the heart and brain. ELISA Tech Aurora Genesis Laboratories, Inc. C Horizon Therapeutics www.elisatech.com Wellington Illinois Provides immunoassays for the www.genesislabs.com www.horizontherapeutics.com measurement of cytokines, growth factors, Provides services to clients in the Horizon Therapeutics plc is a and lipid inflammatory mediators. agrochemical and pharmaceutical industries, biopharmaceutical company focused on rodenticide research and development, improving patients’ lives by identifying, Entero Track as well as invasive species, zoonotic developing, acquiring and commercializing Centennial disease, and conservation research. differentiated and accessible medicines that www.enterotrack.com address unmet medical needs. We market Next generation monitoring of GeneThera, Inc. 11 medicines through our rare disease, gastrointestinal allergic diseases. Westminster rheumatology and primary care business units. www.genethera.net C Evolve Biologics Develops and markets the latest molecular Hospira - a Pfizer company Ontario, Canada technologies to eradicate “cross over” diseases Boulder www.evolvebiologics.com such as Johne’s Disease, Mad Cow Disease, www.hospira.com Evolve is a new kind of biologics company Chronic Wasting Disease, and E.coli. Develops Supplies injectably generic and specialty founded for a clear purpose: bringing critical assay tests and vaccines to eradicate the pharmaceuticals. The Colorado site plasma proteins to the people who need them. threat to humans of diseases transmitted specializes in the supply of active C Flagship Biosciences, Inc. up the food chain by cattle, elk and deer. pharmaceutical ingredients for both Westminster internal and external markets. GenoFAB www.flagshipbio.com Boulder C i2 Pharmaceuticals, Inc. Flagship Biosciences Inc. delivers www.genofab.com Boulder comprehensive tissue profiling for predictive Today, biotechnology products are engineered www.i2pharma.com diagnostics in drug therapy using an Artificial rather than discovered. R&D programs go Creates tools for pharmaceutical drug Intelligence (AI) enabled computational through iterations of a data-driven product discovery and development, in addition to tissue analysis (cTA®) pathology analytics development cycle. We develop an ecosystem proprietary medicinal chemistry services for the platform. Our intuitive data reporting gives of software applications that help life- expansion of intellectual property protection researchers, clinicians, and drug developers science organizations design, fabricate, and of early- late-stage pharmaceutical assets. the actionable information needed to drive characterize synthetic DNA molecules. better clinical results for patients. By delivering C IASO Biomedical, Inc. novel, useful tissue data in a timely manner, C GlaxoSmithKline Centennial Flagship has become an indispensable United Kingdom www.iasobiomedusa.com partner to bio/pharma companies in their www.gsk.com Developing a drug as an alternative development of novel therapeutics. Produces medicines that treat six major disease to currently-available testosterone areas – asthma, virus control, infections, mental replacement therapy by stimulating the C FluoroFinder, LLC health, diabetes and digestive conditions as body’s own production of testosterone. Broomfield well as vaccines and new treatments for cancer. www.fluorofinder.com ICVrx, LLC Software as a Service (SaaS) experiment design C GlobeImmune, Inc. Denver tool for flow cytometry, that dramatically Louisville Creating a new treatment category for epilepsy improves a medical researcher’s productivity www.globeimmune.com by reformulating drugs for brain delivery and quality, while reducing costs. GlobeImmune is developing Tarmogen administered through implantable pumps. product candidates to treat cancer Site-specific computerized drug delivery is FluTrends International / STS Health and infectious diseases. promising for improving epilepsy therapy in a Denver, Aurora significant proportion of refractory patients. www.stshealth.com Greffex, Inc. Develops and commercializes products Aurora C IM Therapeutics for the prevention of influenza. www.greffex.com Broomfield Global leader in the delivery of accelerated www.imtherapeutics.com C Gates Biomanufacturing Facility pandemic and bio-terror vaccines using ImmunoMolecular Therapeutics is a Aurora the world’s first universal platform, private clinical stage biotech company www.gatesbiomanufacturing.com the GREVAX™ Vaccine Platform. developing a therapeutic approach for Helps clients accelerate the translation of the treatment of Type I Diabetes. their discoveries into human clinical trials as HemoGenix efficiently and cost effectively as possible. Colorado Springs C Immunoah Therapeutics www.hemogenix.com Aurora C GENASSIST, Inc. Assay development laboratory specializing in www.immunoah.com Greenwood Village developing predictive in vitro assay platforms Focuses on researching and developing www.genassistabcs.com for primary human and animal target cells proprietary antibodies in the field A preconceptional, prenatal and and stem cell hemotoxicity testing. of cancer immunotherapy. pediatric service business that provides consulting services to patients referred C HepQuant, LLC by healthcare providers to help the Aurora patient interpret laboratory test results www.hepquant.com and develop a management plan. HepQuant-E is non-invasive, uses stable (not radioactive) isotopes, and relies on natural, well-defined hepatic functions to measure the portal circulation.

2018-2019 // BIOSCIENCECOLORADO 47 imuTek Laboratories, Inc. Legacy BioDesign, LLC C Merck & Co., Inc. Fort Collins Johnstown New Jersey www.imutek.com www.legacybiodesign.com www.merck.com Develops and markets bovine colostrums Conducts peptide and protein formulation Produces products that cover a broad range for the nutrition and health products and assay development work for biopharma of areas, including heart and respiratory industry. Indication for colostrum companies. The company also specializes health, infectious diseases, sun care and for the passive transfer of antibodies in drug delivery and process development women’s health. Focusing their research (immunoglobulins) in dry powder form. of biotechnology-based products. on conditions that affect millions of people around the world – diseases like Alzheimer’s, InDevR, Inc. C Levana Biologics diabetes and cancer – while building Boulder Denver strengths in new areas like biologics. www.indevr.com www.levanabiologics.com Providing progressive analytical technologies Levana Biologics has partnered with a world- MI Innovations that enhance and accelerate vaccine renowned cell therapy and regenerative Aurora characterization and production. The medicine academic institution and university Provides affordable chemical and biochemical company is also committed to developing to offer the healthcare community quality research & development services, custom next-generation diagnostic products that will products that are manufactured and delivered equipment and equipment modification, enable unprecedented tracking of seasonal and with integrity. Levana Biologics provides safe, prototyping, short run/one off manufacturing emerging influenza viruses around the globe. high-quality bioengineered birth tissues and and technical/scale-up/production consultation biomaterials to the healthcare community for startup companies to large corporations. ingenovax nationally. These “smart” metabolically Broomfield C miRagen Therapeutics active biomaterials supercharge the patient’s www.ingenovax.com Boulder own stem cells to enhance, promote Developing two novel immunotherapies for www.miragentherapeutics.com and stimulate the body’s natural healing medullary thyroid cancer and one prescription Improves patients’ lives by developing process. Our multi-disciplinary approach is eye-drop for ocular surface neoplasms. innovative microRNA (miRNA) based comprehensive and collaborative, providing a therapeutics for the treatment of C Inscripta unique structure that intricately allows for the cardiovascular and muscle disease. miRNAs Boulder alignment of laboratory-to-clinic, producing are a recently discovered class of small www.inscripta.com an evolution in healthcare worldwide. RNAs encoded in the genome, and are Inscripta is a gene editing technology company Living Ink Technologies short, single-stranded RNA molecules. dedicated to creating the tools needed to Aurora revolutionize how we feed, fuel, and heal Molecular BioSciences, Inc. www.livingink.co humanity. This includes developing a family of Boulder Bioscience research and product company CRISPR enzymes (called MADzymes), bespoke www.molbio.com developing the first environmentally safe and nucleases for researchers and commercial Manufactures products such as water soluble sustainable printing inks grown from algae. partners, and a full suite of gene editing biotinylation reagents, vitamin derivatives, tools (software, instruments, and reagents) C Lohocla Research Corporation crosslinking reagents, lipophilic probes, that will significantly increase the speed Aurora fluorophores, radioiodination reagents, and and efficiency of precision gene editing. www.lohocla.com dendritic cores for preparing oligomers. Lohocla Research Corporation is a small, Integrated Molecular Diagnostics MonImmune Therapeutics Colorado-based biotechnology company Pathology, Inc. Fort Collins that has discovered an innovative medicine Aurora www.monimmunetherapeutics.com for the treatment of chronic pain (DCUK). www.imdpath.com Developing a pipeline of repurposed DCUK is a patent-protected compound that Solves problems presented by non-targeted compounds focused on monocyte has demonstrated positive results in animals cancer care by providing oncologists and regulation as vaccine adjuvants. for pain, anxiety and alcohol dependence. pathologists with advanced genomic testing as Lohocla has completed a large number of C Mosaic Biosciences a means of targeting cancer care based on the preclinical studies and is currently completing Denver, Aurora detection and identification of abnormalities the toxicology studies, FDA required, prior www.mosaicbio.com that may be found in cancerous tumors. to approval for testing in humans. Focused on the development of innovative Invenux, LLC materials for tissue regeneration and repair. C Machavert Pharmaceuticals Windsor Aurora Mother’s Milk is Best Research and development for orphan diseases. www.machavert.com Fort Collins C InVitria Develops a new class of immunotherapies to www.mothersmilkisbest.com Fort Collins help the human body to fight various diseases, Developed Human Milk Concentration (HMC) - www.invitria.com such as cancer or autoimmune disorders. advanced filtration technology that produces Develops, manufactures and markets a pure, concentrated mother’s milk containing C MBC Pharma, Inc. portfolio of high performance and well the native essential human proteins, beneficial Aurora defined cell culture products and reagents nutrients and immune factors that promote www.mbcpharma.com used in bioprocessing, biopharmaceutical optimal neonate growth and play a profound Biopharmaceutical company focused on formulation, stem cell & regenerative medicine, role in the survival & health of a newborn. discovering and developing drugs for bone life science research and diagnostics. diseases such as cancer and osteoporosis. Nanoly Bioscience, Inc. C KromaTid, Inc. Denver C MenoGeniX Longmont www.nanoly.info Aurora www.kromatid.com Developing a safe and proprietary polymer www.menogenix.com Develops a method and kit using encapsulation to stabilize and protect Clinical stage biotech company developing chromatid paints to improve detection of therapeutic biological molecules, such as MNGX-100, a therapeutic biologic, as a chromosomal inversions. The improvement vaccines and enzymes, from below freezing novel, non-hormonal, non-SSRI/SNRI, is important to medical applications to beyond tropical room temperatures. alternative to treat hot flashes and related such as cancer and birth defects. vasomotor symptoms in women with natural or surgically-induced menopause.

48 BIOSCIENCECOLORADO // 2018-2019 C = CBSA MEMBER

NanoSphere Health Sciences C Pathways Bioscience, Inc. PrevaCept Infection Control, Inc. New Jersey Aurora Broomfield www.nanospherehealth.com www.pathwaysbio.com www.prevacept.com Created an advanced delivery system platform Focused on discovering and developing new PrevaCept Infection Control, Inc. manufacturers to change the way people take and benefit from agents for modifying gene expression and the best-in-class product for catheter infection nutraceutical supplements and medications. regulating stress response pathways that control, the PrevaCept Lock Solution. contribute to cell defense mechanisms. PrevaCept has been shown to dramatically C Neuraptive reduce the risk of sepsis caused by catheters Lafayette Peak Analytical, Inc. colonized by microbial pathogens. www.neuraptive.com Golden Development-stage surgical product company www.peaklab.net C Pyxant Labs, Inc. bringing to market a surgical therapeutic Specializes in materials and chemical Colorado Springs kit to repair injured peripheral nerves. analysis. Performs a variety of molecular www.pyxant.com and atomic level spectroscopic techniques Provides GLP regulatory bioanalytical support C Novo Nordisk to identify failures and defects. for non-clinical through clinical development Texas programs. Specialties include rare tissues, www.novonordisk.com C Peak Serum RNA and oligonucleotide therapeutics, A global healthcare company with Fort Collins nucleoside antivirals, and agricultural more than 90 years of innovation www.peakfbs.com and industrial biotech applications. and leadership in diabetes care. Our core focus is Fetal Bovine Serum (FBS) for cGMP-QSR / clinical trial research and Quicksilver Scientific C Novus Biologicals, LLC, a Bio-Techne brand diagnostic applications. We provide FBS Lafayette Littleton for all levels of research compliance and www.quicksilverscientific.com www.novusbio.com laboratory settings. Our strong reputation Clinical and environmental mercury lab Develops, tests and markets antibodies for is built on our solutions based approach and dietary supplement manufacturing. research of human diseases such as cancer, and individual needs of our customers. cardiovascular and neurological disorders. Regenexx PeptiVir Broomfield C Ocugen Aurora www.regenexx.com Aurora www.site.peptivir.com Advances stem cell therapies through www.ocugen.com Focused on the development and development of Regenexx™, an Exclusively licensed two novel biological commercialization of a conformationally- injection procedure to treat a wide molecules which have the ability to improve constrained, synthetic peptide-based vaccine variety of painful conditions. patient outcomes in a number of retinal platform for the prevention of viral diseases. disorders including Retinitis Pigmentosa Renaptys Vaccines, LLC (RP), Geographic Atrophy (GA), and other C Pfizer, Inc. Aurora neurodegenerative diseases as well as New York www.renaptys.com wet age-related macular degeneration www.pfizer.com Developing innovative Stable Peptide (Wet AMD), Diabetic Retinopathy (DR), Discovers, develops, manufactures, Immunogen (SPI) platform that targets ɑ-helical and other neovascular diseases. and markets prescription medicines epitopes, initially, fusion receptors on viruses. for humans and animals. Omix Technologies C Respirogen Aurora PhosphoSolutions, LLC Boulder www.omixtech.com Aurora www.respirogen.com Omix Technologies has innovated mass www.phosphosolutions.com Respirogen Oxygen Microbubble (OMB) spectrometry-based workflows to provide Designs and produces phosphoproteins technology will provide improved compositions quantitative proteomics and metabolomics solutions using phosphor-specific antibodies. for blood oxygenation as well as improved analyses with supreme throughput, Phosphoproteins are thought to be methods for producing and delivering these accuracy, and precision. These techniques critical elements in neurological diseases oxygen delivery compositions to patients provide unprecedented insight into complex such as Alzheimer’s and in cancer. or explanted cells, tissues, or organs. Target biological systems, providing unique indications: wound healing, as an alternative Photon Pharma perspectives for the development and treatment to Hyperbaric Oxygen Therapy, Fort Collins improvement of biological products. allowing ambulatory/home care in diabetic www.photonpharm.com ulcers; burn therapy, for improved healing OnKure Develops cancer vaccines, applicable by delivery of oxygenated therapeutics; Longmont to all cancers, using live inactivated critical care applications including peritoneal www.onkuretherapeutics.com tumor cells with full preservation of oxygen delivery in NICU and VA-ECMO. Engaged in the discovery and development neo-antigens and cell structure. of epigenetic therapies for the treatment Reven Pharmaceuticals C Plato Biopharma of cancer that include selective inhibitors Golden www.platobiopharma.com of histone deacetylases (HDACs). www.reven.com PBI’s integrative pre-clinical research A global healthcare company with Op-T-Mune platform generates decision-enabling data more than 10 years of innovation Denver via physiological evaluation of disease and leadership in vascular care. Development of a small peptide to control models, assessment of acute and chronic autoimmune inflammation, specifically in in vivo pharmacologic responses, and type 1 diabetes and multiple sclerosis. evaluation of histologic and contemporary biomarkers across core organ systems. Pantheryx Boulder www.pantheryx.com PanTheryx is a biotechnology company committed to realizing the potential of novel interventions to address a wide range of serious GI microbiome related health conditions.

2018-2019 // BIOSCIENCECOLORADO 49 Rezolute Sinfonia Biotherapeutics C Thermo Fisher Scientific Louisville, California Boulder Lafayette www.rezolutebio.com www.sinfoniabiotherapeutics.com www.thermofisher.com Rezolute is a clinical stage biopharmaceutical Developing novel, bioreactor-delivered Scientific leadership and innovation in RNAi, company specializing in the development treatments for familial and genetically - Gene Expression, qPCR/PCR Detection, and of innovative drug therapies to improve the defined orphan neurodegenerative diseases. Molecular Biology technologies come together lives of patients with metabolic and orphan with the Thermo Scientific Dharmacon, C STAQ Pharma diseases. Rezolute is advancing a diversified Open Biosystems, ABgene, Finnzymes, and Denver portfolio including: RZ358 (Phase 2), an Fermentas product lines to provide world- www.staqpharma.com antibody for the ultra-orphan indication of leading solutions for gene analysis. 503B Outsourcing facility. Focused Congenital HyperInsulinism (CHI), with an on sterile, pre-filled syringes. C Tolmar abbreviated path-to-market strategy; AB101 Fort Collins (Phase 1), a once-weekly injectable basal C Steadman Philippon Research Institute www.tolmar.com insulin with the potential to transform the Vail A fully integrated pharmaceutical treatment landscape in diabetes management www.sprivail.org company focused on the development, by reducing the therapeutic burden for patients Orthopedic sports medicine, SPRI is unlocking approval, and commercialization of and improving compliance; and a Plasma the secrets of healing, finding cures and specialty pharmaceutical products. Kallikrein Inhibitor (PKI) portfolio with two lead enhancing lives through regenerative medicine, compounds, RZ402 targeting Diabetic Macular scientific research, innovation and education. TopGear Automation Edema (DME) and RZ602 targeting Hereditary Denver Sudhin Biopharma Company Angioedema (HAE), an orphan indication. www.topgearautomation.com Superior Development and validation of Rocky Mountain Biosystems, Inc. www.sudhinbio.com biomarkers for environmental exposure, Wheat Ridge Sudhin Biopharma Co. develops oncology, and related diseases. Research and development of transdermal novel continuous and more efficient pharmaceuticals and delivery systems, biopharmaceutical manufacturing C TopoGEN, Inc. cosmetic devices, and tissue adhesives. technologies. Its first product is single Buena Vista use disposable plastic BioSettler, which www.topogen.com Rocky Mountain Diagnostics, Inc. can be used to (i) remove dead cells and TopoGEN, Inc. is a mature biotech company Colorado Springs cell debris selectively while recycling live that markets and sells R&D reagents globally www.rmdiagnostics.com and productive cells back to the perfusion in the anti-cancer and antibiotic space. We Provides immunodiagnostic assays and bioreactor, (ii) clarify cell culture broth at are also an established CRO specialized in reagents for biogenic amines, research the end of fed-batch cultures, (iii) capture high throughput drug screening in these reagents, a CLIA certified reference laboratory secreted antibodies directly on protein A areas. We have >10 global distributors and and contract manufacturing services. beads suspended inside the settler to replace actively export products to Asia, the E.U Rocky Mountain Instrumental Laboratories column chromatography, (iv) purify and and many other countries. TopoGEN is also Fort Collins separate ex vivo expanded mesenchymal well funded with multiple SBIR grants. www.rockylab.com stem cells from microcarrier beads, etc. UBP Bio Provides contract chromatographic and mass C SuviCa, Inc. Aurora spectrometric analysis of pharmaceuticals Boulder www.ubpbio.com (both traditional drugs and biotechnology www.suvica.com Manufactures and sells bioreagents related products, such as proteins and peptides and Discovery and development of small to the ubiquitin-proteasome pathway. The oligonucleotides), veterinary and human molecules for the treatment of cancer. ubiquitinproteasome pathway is responsible for endocrinology, and forensic toxicology. degradation of the majority of cellular proteins. C Taiga Biotechnologies, Inc. Rocky Mountain Reagents, Inc. Aurora C Ultragenyx Pharmaceuticals Golden www.taigabiotech.com California www.rmreagents.com Taiga Biotechnologies, Inc. is a clinical www.ultragenyx.com Manufactures stains, culture media and stage company focused on improving blood Ultragenyx is a biopharmaceutical company chemistry solutions for the medical stem cell transplantation and harnessing committed to bringing to patients novel industry, as well as titration reagents, the power of the immune system to products for the treatment of rare and indicators, acids, bases, and a variety fight infectious disease and cancer. ultra-rare diseases, with a focus on serious, of chemicals for industrial uses. debilitating genetic diseases. Founded in Teleost Biopharmaceuticals Saigene Biotech, Inc. 2010, the company has rapidly built a diverse Boulder Denver portfolio of approved therapies and product www.teleostbio.com www.saigene.com candidates aimed at addressing diseases with Teleost Biopharmaceuticals will help people Developing testing processes to high unmet medical need and clear biology, protect themselves from sun damage by identify harmful algae blooms. for which there are no approved therapies. stimulating melanin production in the body by The company is led by a management Sandoz a method not triggered by the sun’s UV rays. team experienced in the development and Broomfield The BioCollective, LLC commercialization of rare disease therapeutics. www.us.sandoz.com Centennial Ultragenyx’s strategy is predicated upon Focuses on pharmaceuticals, consumer www.thebiocollective.com time and cost-efficient drug development, health, generics, eye care and animal Biobanking company for microbiome with the goal of delivering safe and effective health. Therapeutic categories include anti- samples. Initial research focus is on epigenetic therapies to patients with the utmost urgency. infectives, anti-arthritics, cardiovasculars, impact of microbiome metabolites through gastrointestinal agents & psychotherapeutics. Upsher-Smith Laboratories, Inc. technology developed by its partner, Topogen, Denver C Silvergate Pharmaceuticals, Inc. using a topoisomerase reporter system. www.upsher-smith.com Greenwood Village Develops, manufactures and markets a vast www.silvergatepharma.com range of prescription and over-the-counter Developer and manufacturer of pharmaceutical products for cardiology, dermatology, products focused on the pediatric market. women’s health and other areas.

50 BIOSCIENCECOLORADO // 2018-2019 C = CBSA MEMBER

Ursa Medical Technologies C Watchmaker Genomics Animal Health Options Aurora Boulder Golden www.ursamedical.com www.watchmakergenomics.com www.animalhealthoptions.com Research company developing a breast Watchmaker Genomics combines deep domain Offers high quality antioxidants and cancer treatment compound researching expertise in protein engineering with enzyme nutritional supplements that meet or the use of enzyme inhibitors in the manufacturing to address the demanding exceed industry standards and provide a cholesterol biosynthetic pathway to explore quality, performance and scale requirements noticeable benefit to dogs, cats and horses. the safety and efficacy of the compound of high-growth genomics applications. on a variety of hormonal cancers. Animark, Inc. Xalud Therapeutics Aurora C Ventria Bioscience Boulder www.animark.us Fort Collins www.xaludthera.com Manufactures and sells ultrasound www.ventria.com Novel therapies for the treatment of pregnancy detectors and ovulation Develops a protein expression technology neuro-inflammatory diseases and predictors for livestock breeding. platform called ExpressTec with a product inflammatory joint disorders. pipeline in human nutrition and therapeutics. AnImmune, LLC Yarra Therapeutics Golden Verkko Biomedical, LLC Boulder Infectious disease-centric company focused Aurora Treatment for rare degenerative heart disease. on enhancing efficacy of animal vaccines www.verkkobiomedical.com using knowledge accumulated through YewSavin, Inc. Commercializing combustion synthesis decades of human vaccine technology. Fort Collins technology and manufacturing medical grade www.ajorganica.com customized alpha-, beta-phase tricalcium Aquatic BioSystems Develops chemical and biochemical phosphates as precursor components. Fort Collins technologies. Successfully finished www.aquaticbiosystems.com C Vertex Pharmaceuticals, Inc. multi-step syntheses using Bromination, Full-service organism culturing facility Massachusetts Grignard reaction, Suzuki coupling, specializing in the production and distribution www.vrtx.com Amidation, and Esterification reactions. of freshwater and marine organisms Aims to discover, develop and commercialize for aquatic toxicology, biomonitoring yuScience, LLC innovative medicines so people with and other research activities. Aurora serious diseases can lead better lives. Focusing on the development of Ardent Mills VisuGen Global, LLC early disease biomarkers in patients Denver Aurora with multiple sclerosis (MS). www.ardentmills.com www.visugenglobal.com Offers the industry’s broadest range Z Biotech, LLC Advancing a new approach to concentrate of flours, mixes, blends and specialty Aurora and detect gene targets in a method that products. More than 40 community mills www.zbiotech.com is simple to perform anywhere needed. and mix facilities, along with a specialty Cost-effective biochemical analysis bakery and a Mobile Innovation Center. VitriVax, Inc. solutions with a focus to develop Boulder innovative microarray and carbohydrate C Bayer A platform technology enabling the preparation products and related services. www.bayer.com of thermostable, single-shot vaccines. Global provider of technology-based solutions Zalgen Labs, LLC and agricultural products that improve C VitroBiopharma Aurora farm productivity and food quality. Golden www.zalgenlabs.com www.vitrobiopharma.com Specializing in the design and production BioServe Space Technologies Develops and commercializes adult stem of superior biological molecules critical for Boulder cell technology for applications in stem cell the development and commercialization www.colorado.edu/engineering/BioServe/ research, drug discovery & development of reliable, rapid, and affordable diagnostic Researches space life science with a wide and therapeutic products for treatment of platforms, immunotherapeutics and range of biotechnology applications involving disease, injury and tissue regeneration. novel vaccines targeting neglected and animals, plants and microorganisms. underrepresented human infectious diseases. Vitrolife, Inc. C Bond Pet Foods™ Englewood Zenith BioPharma Aurora www.vitrolife.com Aurora www.bondpets.com Develops, manufactures and sells products A cancer therapeutics research and In a process similar to craft brewing, we start and systems for the preparation, cultivation development company focused on with live cells from an animal (no slaughter and storage of human cells, tissue and targeting cancer stem cells, cancer required) and feed them a nutrient-rich organs. Product areas include fertility, metastasis and recurrence. broth of vitamins and minerals. The same transplantation and stem cell cultivation. ones an animal would eat on farm and field, only without the pharmaceuticals. C Vivaldi Biosciences AG BIO/ANIMAL HEALTH Fort Collins CarboAnalytics www.vivaldibiosciences.com Advanced Regenerative Therapies (ART) Fort Collins Developing advanced vaccines for Fort Collins www.carboanalytics.com prevention of common seasonal influenza www.art4dvm.com Develops systems that give accurate sugar (“flu”) and emergent pandemic flu. Provides a stem cell isolation and expansion analysis for the brewing and distilling, food processing and pharmaceuticals industries. VRL Laboratories service for veterinary medicine. Centennial Agripro COKER Cargill Research www.vrl.net Berthoud Fort Collins Laboratory that offers full service www.agriprowheat.com www.cargill.com regulated donor eligibility testing for the Develops and delivers superior wheat Develops, processes and markets science- human cell and tissue community. seed genetics in North America. based, health promoting ingredients for food and dietary supplement industries worldwide.

2018-2019 // BIOSCIENCECOLORADO 51 Colorado Genetics, Inc. Fresh Cow Manager Industrial Laboratories Co. Loveland Boulder Wheat Ridge www.coloradogenetics.com www.freshcowmanager.com www.industriallabs.net Provides livestock embryo-transfer Fresh Cow Manager gets your An independent third-party research, artificial insemination, embryo cows up and eating when they are analytical laboratory that specializes collection, freezing and transfer, and most nutritionally deprived. in food and drug analysis. international import and export services. Front Range Biosciences International Bovine Training Solutions Colorado Quality Research, Inc. / Lafayette Loveland Feathertech, Inc. www.frontrangebio.com www.bovinetraining.com Wellington Provides industrial-scale tissue culture A training experience focused on www.coloradoqualityresearch.com propagation and advanced breeding improving the reproductive performance Leading innovator in poultry research. for plants that will be less susceptible on dairy and beef operations. to diseases and mold contamination, C C Colorado Serum Company reducing the need to use pesticides. Jonah Ventures, LLC Denver Boulder www.thepeakofquality.com Gene Check, Inc. www.jonahventures.com Supplies veterinary biologic vaccines, Greeley Sequencing DNA using next-generation instruments, laboratory reagents and www.genecheck.com sequencing technology. Areas of service serums for the veterinary industry. Gene Check is a diagnostic laboratory include reconstructing the diet of wildlife C specializing in veterinary genetics. In and livestock, analyzing the abundance Concentric addition, Gene Check maintains a dynamic of organisms in aquatic ecosystems, and Centennial, Canada biotech research program, including rare determining the plants that pollinators rely on. www.concentricag.com DNA sequence and SNP detection. Inocucor uses its proprietary microbial Jorgensen Laboratories, Inc. consortia technology to combine multiple GeneBiologics Loveland beneficial bacteria and yeasts into powerful Boulder www.jorvet.com soil and plant boosters that are economical www.genebiologics.net Designs and manufactures instruments for farmers and greenhouse growers, and Developing organisms to efficiently convert which are used in the animal health field safe for people and the environment. nitrogen in air or liquid waste streams including specialty instruments, surgical into a non-toxic, soluble, concentrated, suture, and veterinary equipment. Dairy Authority slow-release sustainable fertilizer; and the

Greeley directed evolution of enzymes for biosensors Keeton Industries, Inc. Wellington www.dairymd.com and renewable energy applications. A food and animal practice utilizing www.keetonaqua.com the specialties of their veterinarians, Genesis Laboratories, Inc. Researches and develops biological microbiologists and veterinarian technicians. Wellington water treatment, aeration, ozone www.genesislabs.com aeration, solids removal, biofiltration Dairy Tech, Inc. Global leader in the fields of vector and other new technologies. Greeley biology and wildlife research, focusing

www.dairytechinc.com in disease prevention in humans. Lacuna Diagnostics Researcher and manufacturer focusing Fort Collins on early calf development. GeneThera, Inc. www.lacunadisagnostics.com Westminster Lacuna Diagnostics allows veterinarians DVM Systems www.genethera.net to upload diagnostic images for near Greeley Develops and markets molecular technologies instant review by a veterinary pathologist. www.dvmsystems.com to eradicate “cross over” diseases such as Lacuna’s proprietary digital platform creates Technology leader in herd health management. Johne’s Disease, Mad Cow Disease, Chronic an integrated network of hospitals and EI Medical Imaging Wasting Disease and E.coli. Develops assay pathologists, and provides remote, near Loveland tests and vaccines to eradicate the threat instant interpretation of diagnostic images by www.eimedical.com to humans of diseases transmitted up a veterinary pathologist. Lacuna Diagnostics Provider of portable ultrasounds for the food chain by cattle, elk and deer. delivers timely diagnosis and raises the standard of care for veterinary patients. veterinarian and livestock procedures Growcentia to create positive business impacts. Fort Collins Limagrain Eurofins BDI www.growcentia.com Fort Collins Longmont Makes organic soil supplements that www.limagraincerealseeds.com www.eurofinsus.com naturally increase nutrient availability to Through cutting-edge seed-breeding Provides technology-based, scientifically support healthy and vigorous plants. methods, the company brings new, improved seed varieties to market in a fraction of sound services that cover the entire life Hach Company the time possible just a decade ago. cycle from genetics to seed and plant. Loveland Evolutionary Genomics www.hach.com Loveland Products, Inc. Castle Rock, Longmont Focused on providing cleaner water to Greeley www.evolgen.com the world, with improved diagnostics. www.lovelandproducts.com Offers a complete line of high-performance Identifies genes with a high likelihood Heska Corp. input products, with a portfolio of seed of commercial value for downstream Fort Collins treatment, plant nutrition, fertilizer, validation through their proprietary www.heska.com adjuvant and crop-protection products. Adapted Traits platform. Develops advanced diagnostics and Fluid Dynamic Siphons, Inc. specialty products for veterinary practices Lumiere Diagnostics Colorado Springs that focus on companion animals. Fort Collins www.siphons.com www.lumierediagnostics.com Global leader in the manufacture and Innovative solutions for food and water safety. distribution of dosing siphons.

52 BIOSCIENCECOLORADO // 2018-2019 C = CBSA MEMBER

Membrane Protective Technologies, Inc. Summit Plant Laboratories, Inc. Fort Collins Fort Collins MOBILE-DIGITAL HEALTH www.membrane-protect.com www.plantlabs.com Blend of organic plant extracts which improves Applies laboratory plant cloning and AbleLink Technologies artificial insemination pregnancy rates in cows. greenhouse technologies to produce Colorado Springs planting stocks for breeders, greenhouses, www.ablelinktech.com C Microbial Research, Inc. and field crop producers. Addresses the need for well-researched Fort Collins cognitive support technologies for www.microbialresearch.com Syngenta individuals with intellectual disabilities. A veterinary services microbiology Longmont laboratory that conducts GLP and www.syngenta-us.com ADAN.net GCP compliant research trials. Produces agrochemicals and seeds. Denver As a biotechnology company, it www.adan.net MycoTechnology conducts genomic research. Comprehensive Lifetime Navigation Aurora Platform for people with Autism and www.mycotechcorp.com C Terra Chem Labs other developmental disabilities. A food technology company that has developed Denver a natural food processing platform that AIVANTE Health Solutions Verdant BioSciences Corp. is solving some of the biggest challenges Centennial Denver in the food and beverage industry. www.dzeesolutions.com www.verdantbio.com AIVANTE Health Solutions provides Nutrinsic, Inc. Develops plant biochemical regulators that Data Analytics and Decision Support Aurora provide superior plant performance and unlock solutions for optimizing healthcare www.nutrinsic.com the productive power of plants in markets financial and plan selection decisions. Produces a cost-effective, sustainably from floriculture to industrial agriculture. produced protein meal which serves as a Allergy Solutions, LLC C VetDC fish meal replacement (FMR) or additive Denver Fort Collins ingredient for animal feeds, primarily those www.symbiaallergy.com www.vet-dc.com destined for the aquaculture industry. Developed an allergy-management platform Focused on the development of novel allowing providers to perform allergy Optibrand Ltd., LLC devices, diagnostics and therapeutics for tests and prescribe immunotherapy. Fort Collins emerging veterinary markets, including an www.optibrand.com approved therapy for canine lymphoma. Alvy Health Specializes in livestock identification Denver C Veterinary Diagnostic Technology devices and veterinary diagnostics. www.alvyhealth.com Wheat Ridge Developing a digital platform for patient C OptiEnz www.serumtest.com monitoring, critical system management Fort Collins Veterinary diagnostic products. and realtime treatment decision making to www.optienzsensors.com improve acute, emergency and urgent care. Produces innovative biosensors for VetMeasure Fort Collins continuously measuring organic chemical C BehaviorMe www.vetmeasure.com concentrations in water and aqueous solutions. Florida Produces harnesses that enable accurate www.behaviorme.co Pisces Molecular detection of an animal’s health statistics BehaviorMe is developing immersive virtual Boulder to optimize care and treatment options. reality simulations for behavioral specialists www.pisces-molecular.com to use as a tool to better generalize skill sets. Focused on applying molecular genetics Warren Analytical Laboratory Greeley Our VR simulations will give practitioners technology to problems of fisheries www.warrenlab.com the opportunity to teach basic life skills and aquatic conservation biology. Specializes in food microbiology, to individuals with Autism Spectrum Poudre Canyon Therapeutics molecular biology, food chemistry, residue Disorder and developmental disabilities Fort Collins chemistry and nutritional labeling. in a new, innovative, and safe way. www.pcthera.com Burst IQ Developing a pharmaceutical therapeutic Wildlife Pharmaceuticals, Inc. Windsor Colorado Springs that increases the ability of canine and www.wildpharm.com www.burstiq.com feline immune systems to prevent infection Providing pharmaceuticals for the safe Building a secure and open via airborne respiratory pathogens. and humane care of non-domestic platform for health data. Pure Cultures and exotic wildlife species. CareSpan Denver C Longmont www.purecultures.com Zoetis Longmont www.carespanhealth.com Pure Cultures is an AgTech product www.zoetisus.com Connects patients and providers by offering development and manufacturing company Discovers, develops, manufactures and physicians a complete and secure workplace specializing in prebiotics and probiotics commercializes a diverse portfolio of in the cloud that allows healthcare delivery used to support the health of animals and animal health medicines and vaccines consistent with the standards of an in-person reduce antibiotics in our food chain. designed to meet the real-world needs of exam, while leveraging the economic SiVEC Biotechnologies veterinarians and the livestock farmers and scalability and efficiency of the internet. Fort Collins companion animal owners they support. CirrusMD www.sivecbiotechnologies.com Denver Developing antiviral products for the rapid www.cirrusmd.com prevention of economically important diseases. Developed a platform to connect patients Currently focused on developing SiVEC-AIV, a and providers via text messaging without patent-pending antiviral for avian flu in poultry. putting personal health information at risk.

2018-2019 // BIOSCIENCECOLORADO 53 CIVHC gaugewear, Inc. C Medecipher Denver Boulder Denver www.civhc.org www.gaugewear.com www.medeciphersolutions.com Helps Colorado drive, deliver and buy value in Developing the first wearable, wireless, non- Medecipher helps hospitals improve the quality health care by administering the Colorado All invasive core body temperature sensor. of care for patients, improve the quality of Payer Claims Database; unlocking information the work environment for staff, and reduce

and insights that guide how healthcare gets Global Healthcare Exchange (GHX) operating costs with a suite of proactive Louisville delivered, used and paid for; and bringing planning and EMR-integrated real-time decision www.ghx.com together organizations and individuals support tools for optimizing clinical operations. Help healthcare providers reduce costs by to design and drive collective change. automating the supply chain and providing MedKeeper C Cliexa business intelligence tools to help them Arvada Denver make smarter and faster decisions. www.medkeeper.com www.cliexa.com Provides a suite of fast, flexible, and economical C Provides decision support to physicians and Health Scholars applications for hospital pharmacies. Westminster other healthcare providers during the treatment www.healthscholars.com process and optimizes treatment methods METHOD, LLC Improve patient safety with Health Aurora based on evidence-based knowledge and data. Scholars One™ learning software, www.themethoddifference.com CORHIO simulation management, and Bridges the gap between exercise and Denver virtual reality medical training. medicine to optimize performance, monitor www.corhio.org and speed recovery and prevent injury. C Its health information exchange (HIE) Health Sqyre Denver C technology, data analytics tools and consulting MFB Fertility www.healthsqyre.com Boulder help healthcare providers access information Digital health e-commerce platform that www.proovtest.com to save lives, streamline care coordination, empowers patients with tools that allow Proov™ rapid response test strips reduce costs and improve clinical outcomes. them to price compare and use their empower women to know more about DARTNet Institute insurance to buy medical supplies online. their mentrual cycles and progesterone Aurora levels in five mintues, at home. C www.dartnet.info Hippo Health Boulder The DARTNet Institute is a rapidly growing Mindful Labs www.hippohealth.com Aurora collaboration of practice-based research Communication platform for clinicians www.getmindful.co networks that are building a national collection and patients. Easy care collaboration Collects monthly hair samples from users of data from electronic health records, for your entire care team. through the mail. A CLIA certified lab claims, and patient-reported outcomes. translates this into the average monthly

DreamFace Technologies Incendant cortisol levels viewable on a mobile phone, Pueblo Denver allowing customers to monitor cortisol www.incendant.com www.dreamfacetech.com levels and take corrective action. Created a web-based, patient engagement “Ryan” is a social companion robot platform that enables providers to for dementia patients who delays the Mobile Assay automatically engage patients with video/ Boulder onset of advanced dementia through email education and SMS reminders. www.mobileassay.com stimulating games, music and crafts. Created a lab-on-mobile-device platform

EMS Relay IngeniumCare with customizable smartphone diagnostic Denver Broomfield tools for use with any rapid diagnostic www.ingeniumcare.com www.emsrelay.com test or colorimetric assay. Its automated Provides support for patient home Developed a mobile app allowing mReader™ imaging system transforms monitoring and provides wireless EMS responders to send images and ordinary qualitative (positive/negative) tests biometric feedback to caregivers. video from the field to the ER. into highly sensitive quantitative tests.

EngageMyHealth, LLC iTriage C MuscleSound, LLC Denver Centennial Denver www.itriagehealth.com www.engagemyhealth.com www.musclesound.com A platform for consumers to get medical Provides a software based solution for MuscleSound is a software technology answers, find care options and securely elective healthcare centers. The integrated that automates the analysis of maintain health information. platform covers mobile centric digital musculoskeletal ultrasound images. communication to patients and prospects, Matrix Analytics, Inc. We are the MuscleHealth company. before, during and after their office visits. Denver My Rounding www.matrix-analytics.com C Etta Epidermis Denver The Nodule Project is Matrix Analytics’ Illinois www.myrounding.com clinical decision support platform www.etta.io A platform that allows healthcare designed to improve patient outcomes Etta is an Artificial Intelligence that uses providers to standardize, automate by aiding in the early detection, massive datasets of hospital-verified images and track their rounding activity. It diagnosis, and cost-effective treatment of to provide a data-driven skin insight. The allows nurses and staff to be proactive, pulmonary nodules and lung cancer. insight that Etta provides is determined by improving care and patient experience. level of risk (Low, Medium, High). Values for MedAware Systems Myonic Technologies accuracy, precision, recall, sensitivity and Broomfield Boulder specificity are used to determine your risk. www.medawaresystems.com www.myonic.tech Provides healthcare professionals, payers, Creates enabling technology for users with patients, pharma and medical device paralysis. Gives users back the ability to control companies with actionable information on their own muscles with a wearable device. the efficacy and safety of medical treatments to make the best decisions for each patient.

54 BIOSCIENCECOLORADO // 2018-2019 C = CBSA MEMBER

myStrength PrecisionProfile, Inc. Script Adviser Denver Boulder Greenwood Village www.mystrength.com www.precision-profile.com www.scriptadviser.com Created a platform to help healthcare Precision medicine for data analysis and Improves the treatment of infectious payers and providers extend access visualization toolset for genomic profile data disease through collaboration with other to evidence-based resources to help that integrates research literature, clinical trial healthcare practitioners and their patients consumers better manage depression, formation and molecular diagnostic reports. via cloudbased video conferencing anxiety and substance abuse disorders. and decision support technology. Predictive Recognition Now Vitals Boulder Self Aware Apps Aurora www.recogdata.com Denver www.nowvitals.com Helps hospitals recognize and predict www.selfawareapps.com Phone case and software that records patient risk and improve quality of care. Creates assistive intelligence engines vital signs, teling you when you’re “off- that help people live better lives by

baseline” or starting to get sick. Preventative Technology Solutions enabling their mobile device to hear, see Loveland and sense the world around them. Nymbl Science www.mypreventtech.com Boulder PreventTech creates medical assessment Skindroid www.nymblscience.com applications and mHealth prevention services Aurora Combines medical science with mobile to reduce risk behaviors in adolescents www.skindroid.io technology to allow people to easily measure and young adults. Our proprietary Developed new skin sensor technology to their balance, and then recommends measures support predictive analytics detect key parameters of basic metabolic panel a program to improve balance. at the clinic and population levels. from a user’s sweat. Skindroid is a wearable biosensing hardware device that allows C OpiSafe Prima-Temp, Inc. remote, non-invasive BMP monitoring via FHIR Denver Boulder API integration with health data platforms. www.opisafe.com www.prima-temp.com Data collection and analysis for unmatched Innovative biometric approaches to Skywriter MD opioid intelligence and solutions. early disease detection and reproductive Westminster medicine through the application www.skywritermd.com

OptioSurgical of 21st century thermometry. Provides real-time, virtual medical scribe Denver services that navigate the EMR and enter data, www.optiosurgical.com Radish Systems execute tasks and write orders as directed. Provides affordable healthcare through vendor Boulder transparency and advanced analytics. The www.radishsystems.com Sleep Image company’s orthopedic database provides Its mobile enterprise software, Denver vendor-by-vendor cost comparisons of ChoiceView, allows businesses to share www.sleepimage.com equivalent tools, implants and disposables. visuals with patients in real-time. Develops a system to measure sleep, receive a clinically-validated indicator of sleep health and C Ortho Track RxREVU learn how behavioral changes can impact sleep. Denver Denver www.orthotrack.co www.rxrevu.com Sleep Shepherd Replaces the antiquated manual paper- RxREVU’s Prescription Decision Support Colorado Springs based process of recording implants with an platform is a first-of-its-kind tool that provides www.sleepshepherd.com intraoperative iPad application that leverages prescribing guidance for providers within the Developed a device to improve sleep in a proprietary database of orthopedic products EHR workflow. It delivers a unified patient people with sleeping disorders or people who and equivalencies. After tracking what is used view that evaluates safety protocols, formulary simply want to improve the quality of their in surgery OrthoTrack displays a surgeon and benefit data, and clinical best practices to sleep, using EEG brainwave monitoring and by surgeon breakdown of cost, savings recommend the most appropriate medication a binaural beat system to slow the brain rate opportunities, and patient reported outcomes. at the point of prescribing while reducing the from an awake state to a sleeping state. time it takes for a provider to prescribe. It C Physia enables hard-wired communication at the point Socon Health Aurora Denver of care, to inform prescribers, drive consistent www.physia.life www.soconhealth.com prescribing, lower costs, inform adherence, Physia provides smart garments that monitors A HIPAA compliant telemedicine and and improve quality metrics for HEDIS and respiratory and cardiovascular failure as well as patient engagement technology that allows Stars. It also provides real-time analytics diabetes and thyroid disorder in elderly patients patients and providers to communicate tools, allowing administrators to monitor best with frequent occurrences with the assistance asynchronously via video messaging. practices and evaluate provider performance of artificial intelligence and machine learning. to clinical protocols and outcomes. Somno Health, Inc. Golden Physician Cognition SafeImageMD Telluride www.geteversleep.com Denver www.physiciancognition.com EverSleep gives hospital-grade measurements www.safeimagemd.com Created a differential diagnosis search engine to you at home without doctors, clinics, Created a secure transfer and storage to minimize misdiagnoses and prevent or prescriptions. Continuously monitor technology allowing providers to unnecessary testing and procedures. blood oxygen, pulse, snoring, motion, and share critical medical images with respiratory function while understanding colleagues, patients, physicians and PreAcute PHM, Inc. what’s disrupting your sleep and how to fix Aurora institutions anywhere in the world. it. Discover techniques, tips, and products www.preacutephm.com Sana Health specific to you. Take control of your sleep! Helps lower healthcare expenditures using Boulder its predictive clinical data analytics platform www.sana.io to focus on pre-acute clinical interventions Sana is the world’s first pain & to treat patients in the early stage of their sleep management mask, aiding illness, when they can often benefit from people around the world. alternative, low-cost point treatments.

2018-2019 // BIOSCIENCECOLORADO 55 Sonaura, LLC C Wellian physicians to further the advancement of Fort Collins Boulder healthcare. From pioneering new models www.mysonaura.com www.wellian.com of care delivery to creating partnerships An electronic two way communication Wellian™ is a wellness platform to correlate within and outside of CHI, CIRI provides a system between patient and doctor your lifestyles/habits with your health research community fostering innovation allowing women undergoing IVF treatment conditions and symptoms in order to help in three distinct areas: 1. Center for Clinical to perform their sonograms at home you improve your overall wellness. Research (CCR): Sustaining clinical research during the follicle stimulation cycle. and trials is costly and challenging. By creating Wellness Intel a national model that uses standardized Sopris Health Denver procedures, policies and IT infrastructures, Denver www.wellnessintel.com CCR efficiently and effectively manages www.soprishealth.com Developing an application to help clinical trials across CHI’s hospital network. Improving physician satisfaction by patients make informed decisions 2. Center for Health Care Innovation (CHCI): dramatically reducing data entry. about their healthcare. CHCI pioneers new ways to deliver health Tech-X Corporation care. This center is focused on creating and testing new models that will enhance care Boulder RESEARCH & EDUCATIONAL www.txcorp.com and better manage populations. 3. Center for Specializes in scientific and engineering INSTITUTIONS Translational Research (CTR): The emerging software, including visualization and revolutionary field of biomedicine C Advanced Diagnostic Laboratories (Adx) at and algorithm development. and genomics is the focus of CTR. National Jewish Health Test Appropriate, LLC Denver Centers for Disease Control and Prevention/ Littleton www.njlabs.org Division of Vector-Borne Infectious Disease www.testappropriate.com National Jewish Health is known worldwide Fort Collins Provides a cloud-based web tool that for treatment of patients with respiratory, www.cdc.gov/ncezid/dvbd allows clinicians to write orders during cardiac, immune and related disorders, and The Division of Vector-Borne Infectious a patient visit for cardiac tests. for groundbreaking medical research. The Diseases (DVBID) is part of the U.S. Centers for Disease Control and Prevention (CDC). C Advanced Diagnostic Laboratories provide TRIDENS innovative services within the extraordinary CDC is the lead federal agency for protecting Arvada, Arizona clinical and research environment of National the health and safety of people at home www.tridens.co Jewish Health. Leveraging our expertise in and abroad. DVBID serves as a national and TRIDENS provides unique and meaningful both laboratory medicine and personalized international reference center for vector-borne benefits to our clients through differentiating medicine, we offer an ever-expanding menu viral and bacterial diseases, such as West Nile platforms that increase business of diagnostic tests, as well as contract virus, Lyme disease, plague, tularemia, yellow efficiency, improve patient outcomes, research services. Our laboratories are CAP fever and dengue. It coordinates national and enhance physician quality of life. and CLIA certified, and have earned the disease monitoring activities, conducts ValidCare, LLC prestigious CAP 15189℠ accreditation. field and laboratory research, responds to epidemic situations, develops strategies for Centennial C BioFrontiers Institute www.validcare.com disease prevention and control, provides Boulder diagnostic reference and epidemiologic Creates value-based surgical care models www.biofrontiers.colorado.edu through collection and use of real-time, consultation, and conducts technical assistance State-of-the art research and education facility and professional training activities. patient-reported data. Providers use the data that links the basic sciences, engineering, to power care navigation and measure and clinical practice, and industry at the Children’s Hospital Colorado improve cost and quality of care delivered. University of Colorado’s Boulder campus. Aurora C www.childrenscolorado.org Velóce Biological Sciences Curriculum Study (BSCS) Denver Children’s Hospital Colorado has been ranked Colorado Springs for more than a decade as one of the best www.velóce.com www.bscs.org Wireless drug delivery and monitoring systems. children’s hospitals nationally in U.S. News A nonprofit corporation that endeavors & World Report, and is the consistent choice Visible Hand to improve all students’ understanding eight years in a row by area physicians for the Denver of science and technology by developing care of their loved ones. With 1,130 pediatric www.visiblehand.com exemplary curricular materials, supporting specialists and more than 2,300 full-time The Foresight app from VisibleHand provides their widespread and effective use, providing employees, Children’s Colorado is home to real-time collaborative intelligence for professional development, and conducting a number of nationally and internationally behavioral care facilities that helps them research and evaluation studies. recognized medical programs including the document, share and implement resident data. Bonfils Blood Center Center for Innovation, providing an opportunity for innovators to come together to develop C Visible Network Labs Denver groundbreaking ideas that will enrich and save Denver www.bonfils.org lives through better technology and healthcare. www.visiblenetworklabs.com One of the nation’s leading community blood Visible Network Labs (VNL) is a social centers through their commitment to quality C Colorado School of Mines enterprise whose mission is to facilitate a service, innovation, research and technology. Golden supportive network of people, organizations Offering a full range of blood products and www.mines.edu and communities who believe in the services to healthcare partners, including A public research university internationally value of working together. We provide supplying rare blood units or helping to recognized for its leadership in engineering, training, opportunities for collaborative determine the best cross-matched unit to applied science and related disciplines, with a innovation, and technology-based tools ensure the best possible patient outcomes. special emphasis on the Earth and its resources. that help people leverage network science CHI Institute for Research and Innovation These programs, with strong interdisciplinary to strengthen supportive connections and (CIRI) linkages across the campus, have led to the improve the outcomes of their work. Englewood integration of bioscience and biotechnology www.chiresearch.org into educational and scholarly activities. Founded by Catholic Health Initiatives (CHI) CSM has created a Bioengineering and Life in 2007, the CHI Institute for Research and Science Program that draws upon faculty and Innovation partners with CHI hospitals and students from all of the academic units.

56 BIOSCIENCECOLORADO // 2018-2019 C = CBSA MEMBER

C Colorado State University at CU’s Anschutz Medical campus with a an environment conducive to information Fort Collins, Pueblo, Denver variety of commercialization programs exchange, generation of new ideas, and www.colostate.edu in the University and the community. acceleration of applications that benefit society. As one of the nation’s leading research DARTNet Institute National Institute of Standards and universities, Colorado State University Aurora Technology (NIST) is committed to realizing its vision as a www.dartnet.info Boulder 21st century landgrant university. CSU The DARTNet Institute is a rapidly growing www.nist.gov leads the world in such areas as infectious collaboration of practice-based research NIST is a non-regulatory federal agency that disease research, atmospheric science and networks that are building a national collection operates eight different science and advanced environmental science. Its faculty members of data from electronic health records, technology research divisions in Colorado. are tackling such issues as the reemergence claims, and patient-reported outcomes. NIST’s list of research accomplishments of tuberculosis, the brown cloud of air includes a NIST senior scientist winning the pollution in Asian cities, severe weather Denver Botanic Gardens Nobel Prize in 2001 for creating the world’s forecasting, nutrition and wellness, and Denver first “Bose-Einstein condensate.” In 2003 bioterrorism. In addition to its excellent www.botanicgardens.org another NIST scientist won a MacArthur programs in those areas, CSU offers among One of the top-ranked botanical gardens Fellowship for discovering a new quantum the very best professional programs in in the U.S., Denver Botanic Gardens offers gas and was named by Science as one of the United States in areas like veterinary spectacular plant displays and unlimited the top ten scientific advances of the year. medicine, occupational therapy, journalism, opportunities for lifelong learning. agriculture and construction management. C National Jewish Health Denver Museum of Nature and Science Denver Craig Hospital Denver www.njhealth.org Denver www.dmns.org National Jewish Health, the nation’s #1 www.craighospital.org The Denver Museum of Nature & Science is respiratory hospital in the U.S., attracts A world-renowned rehabilitation hospital the Rocky Mountain region’s leading resource thousands of adult and pediatric patients that exclusively specializes in the neuro- for informal science education. A variety of each year who come to us to team up with our rehabilitation and research of patients exhibitions, programs, and activities help expert physicians and researchers and seek with spinal cord injury (SCI) and traumatic Museum visitors experience the natural treatment for respiratory, cardiac, immune and brain injury (TBI). Craig is a not-for-profit, wonders of Colorado, Earth, and the universe. related conditions. National Jewish Health is free-standing, national center of excellence Its Expedition Health exhibit examines how also one of the most influential independent that has treated more than 31,000 the human body is constantly changing biomedical research centers in the world. patients with SCI and TBI since 1956. and adapting in ways you can see, measure More than 100 faculty members conduct and optimize through choices you make. CSU BioMARC basic, translational, and clinical research in Fort Collins Denver Research Institute immunology, respiratory medicine, allergy, www.biomarc.colostate.edu Denver cancer, and cell and molecular biology. A nonprofit CMO owned and operated by www.dri-va.org Power Mountain Engineering, Inc. Colorado State University created to translate Denver Research Institute (DRI) serves as the Fort Collins and produce biopharmaceutical products non-profit organization affiliated with the www.powermountainengineering.org for non-clinical, clinical, and commercial VA Eastern Colorado Health Care System. It Nonprofit afterschool program for gifted and use under Biosafety Level 3 (BSL-3) and is dedicated to research and its associated talented students in grades 8-12 who are BSL-2 containment (including spore former educational and scientific endeavors. interested in a STEM career. Students meet containment) and Select Agent (SA) biosecurity with community volunteers for an entire conditions. In addition to manufacturing Front Range Community College semester to design and build an advanced and testing services, BioMARC offers product Brighton, Fort Collins, Longmont and project from raw materials. The program and process development services, which Westminster encourages our best students to take up includes the creation of development www.frontrange.edu college studies in STEM by immersing them programs focused on implementation of Front Range Community College, Colorado’s in an authentic, hands-on R&D experience. cGMP regulations and scalability issues. largest community college, provides instruction, in both general education and Regis University C CSU Research Innovation Center occupational areas, which may lead to a Denver Fort Collins certificate, an associate degree, or transfer www.regis.edu www.csuric.org to a four-year institution. The college also The School of Pharmacy aspires to be the The Research Innovation Center (RIC) provides college preparatory education, foremost school of pharmacy in the United serves as a vehicle to perform collaborative non-credit instruction for personal and States where students are nurtured and translational-stage research with CSU’s professional development, and workplace developed to become leaders in pharmacy life sciences community of researchers, skill development. With campuses located in practice, research, education, and public giving it the promise to become the Fort Collins, Longmont and Westminster, the service. They are educated to be committed birthplace of medical breakthroughs. college is proud of its many partnerships to to excellence in healthcare, evidenced provide quality programs that are responsive C CU Innovations not only by their knowledge and abilities, to the needs of its local communities. Aurora but also by their quality of care, integrity, www.ucdenver.edu/anschutz/about/cuinnovations C Keystone Symposia on Molecular and Cellular compassion, respect, advocacy, initiative, Brings together industry partners, Biology service and leadership. To achieve these goals, entrepreneurs, and investors to help CU Silverthorne faculty members are dedicated to providing researchers solve important problems www.keystonesymposia.org innovative practice models, exploring novel and improve the quality of life worldwide. A non-profit organization that serves as a applications of basic and clinical research, With expertise in patents, copyrights and catalyst for the advancement of biomedical and illustrating the value of lifelong learning. licensing, CU Innovations helps translate and life sciences, by connecting scientists discovery into impact through transparent, within and across disciplines at conferences flexible, best practice intellectual property and workshops held at venues that create management services, and connect researchers

2018-2019 // BIOSCIENCECOLORADO 57 Rose Medical Center C University of Colorado C University of Colorado Health Denver Boulder, Denver, Aurora, Colorado Springs Loveland, Fort Collins, Colorado Springs www.rosemed.com www.cu.edu www.uchealth.org Has earned a reputation as Denver’s The University of Colorado System’s 52,000 Poudre Valley Health System (PVHS) and “Baby Hospital” while becoming a leader students and 28,000 faculty and staff contribute the University of Colorado Hospital (UCH) in comprehensive women’s services, to every facet of life in Colorado. The state’s finalized a joint operating agreement in early internal medicine, endoscopy, heart and economic vitality, educated workforce, 2012 that creates a health system its leaders vascular care, orthopedics and total joint entrepreneurial climate, cultural capital, health say will widen health care services and replacement, bariatric surgery, sports care delivery, and scientific explorations all provide unparalleled patient care in the Rocky medicine and aesthetic surgery. rely on the driving force of a vigorous state Mountain region. Called University of Colorado university. By working with other CU academic Health, the new system combines one of the Rocky Vista University College of Osteopathic and research units, as well as local, state, and top-performing community health systems in Medicine (RVUCOM) federal funding agencies, commercial business, the nation with the highest-ranked academic Parker and nonprofit organizations, CU is creating a medical center in quality in the country. With www.rvu.edu collaborative synergy in important areas that annual net revenue of $1.5 billion, it will be one Rocky Vista University College of Osteopathic will better the wellness of society. Research of the region’s largest locally-owned health Medicine (RVUCOM ) has five departments and teaching hospitals affiliated with the systems and, with nearly 10,000 employees, – Biomedical Sciences, Structural Medicine, University of Colorado include: The University one of Colorado’s largest employers. Primary Care, Osteopathic Principles and of Colorado Hospital, The Children’s Hospital, Practices, Specialty Medicine and Medical C University of Denver National Jewish Medical and Research Center, Informatics. The faculty and staff of RVUCOM Denver Denver Health and the VA Medical Center. are committed to osteopathic philosophy and www.du.edu heritage, and to advancing the science and the C University of Colorado Cancer Center Strives to provide the most modern educational art of the practice of osteopathic medicine. Aurora and research facilities in the life sciences. Their www.uch.edu/colorado-cancer-center history spans the Denver Research Institute’s Scientific Education & Research Institute The University of Colorado Cancer Center development of the first NASA life monitoring (SERI) is Colorado’s only National Cancer Institute sensors, the establishment of a state-of- Thornton designated consortium comprehensive cancer the-art forensics laboratory, and the 2003 www.theseri.com center. The center is a consortium of three acquisition of the Eleanor Roosevelt Institute SERI combines an orthopedic clinic, specializing state universities, including the University with pioneering efforts in genomics and in spine surgery, with a clinical research unit of Colorado Boulder, University of Colorado bioinformatics. The interdisciplinary mission and an education and training program. Denver and Colorado State University, and six of the University enabled the Department C Steadman Philippon Research Institute institutions (University of Colorado Health, a of Biology to launch new emphases in Vail network comprised of University of Colorado Bioengineering, Biophysics and Cognitive www.sprivail.org Hospital, Poudre Valley Hospital, Medical Neuroscience designed for molecular biology Orthopedic sports medicine, SPRI is unlocking Center of the Rockies and Memorial Hospital; majors. In addition to strong and quality the secrets of healing, finding cures and Children’s Hospital Colorado; Denver Health, curricula, bioengineering and life sciences at enhancing lives through regenerative medicine, Denver VA Medical Center, Kaiser Permanente DU carry multimillion-dollar-a-year research scientific research, innovation and education. Colorado and National Jewish Health). studies in the creation of new knowledge and leading edge biotechnologies to improve C University of Colorado Denver - Center for Swedish Medical Center quality of life for a worldwide community. Englewood Surgical Innovation www.swedishhospital.com Aurora C University of Northern Colorado Level I Trauma Center serves as the region’s www.ucdenver.edu/csi Greeley referral center for neurotrauma and is a A multidisciplinary surgical training center www.unco.edu recognized leader in the treatment of stroke. dedicated to promoting educational The University of Northern Colorado (UNC) An acute care hospital with 368 licensed beds. courses and development of leading edge is a four-year doctoral-granting university surgical techniques and technologies. The with a Carnegie classification of “Doctoral UCHealth Simulation Center center is affiliated with the Department of Universities: Higher Research Activity” (R2). Aurora Surgery in the CU School of Medicine. Established in 1889, UNC combines innovative www.wellssimulationcenter.org teaching opportunities and community C University of Colorado Denver, iC42 The UCHealth Simulation Center on the engagement with scholarly interests and Aurora Anschutz Medical Campus in metro Denver research. The groundbreaking UNC Cancer bioanalytics.us offers a complete array of state-of-the-art Rehabilitation Institute is one example of Research & Development to carry out patient simulation tools for building translational research that reaches well beyond pre-clinical and clinical drug development clinical knowledge and advancing multi- our campus community to international programs, through the evaluation of disciplinary expertise in health care. populations. UNC has garnered more than pharmacokinetics, drug metabolism and $17.5 million in external funding over the last United States Geological Survey (USGS) - the development of clinical management three years, ranging from National Science Center for Biological Informatics tools. iC42 combines quantitative mass Foundation grants in biological anthropology Denver spectrometry and metabolic and protein to National Institute of Health-supported www.biology.usgs.gov/cbi profiling technologies under one roof. studies in psychology. Through research, UNC The Center for Biological Informatics, at iC42 Clinical Research & Development is advances knowledge, engages students and the Denver Federal Center, operates the designed and uniquely qualified to carry makes a difference locally and globally. national Biological Information Infrastructure out the bioanalytics for complex clinical (NBII). This is the first comprehensive trials involving drug quantification and electronic gateway dedicated exclusively molecular marker strategies. In addition, to biological science data and information iC42 carries out research and development from sources throughout the world. projects including molecular marker discovery and qualification, translational research and strategy development and the identification of molecular mechanisms.

58 BIOSCIENCECOLORADO // 2018-2019 C = CBSA MEMBER

CIVHC C Innosphere MEMBER FOUNDATIONS Denver Fort Collins, Denver, Boulder www.civhc.org www.innosphere.org C Boettcher Foundation Webb-Waring Helps Colorado drive, deliver and buy value in A high-tech incubator supporting entrepreneurs Biomedical Research Program health care by administering the Colorado All building high-growth companies in the Denver Payer Claims Database; unlocking information industries of health innovation, life sciences, www.boettcherfoundation.org and insights that guide how healthcare gets software & hardware, and energy & advanced The Boettcher Foundation invests in the delivered, used and paid for; and bringing materials. Innosphere’s incubation program promise of Colorado and the potential of together organizations and individuals focuses on ensuring companies are investor Coloradans. Its Webb-Waring Biomedical to design and drive collective change. ready, connecting them with experienced advisors, and making introductions to Research Awards provide biomedical CORHIO corporate and strategic partners. research funding for early career investigators Denver at Colorado’s research institutions. Our www.corhio.org PDA MS (Parenteral Drug Association, biomedical research institution partners Its health information exchange (HIE) Mountain States Chapter) manage their own internal, competitive technology, data analytics tools and consulting www.pda.org/chapters/north-america/ and peer-reviewed application processes. help healthcare providers access information mountain-states For information, contact your institution. to save lives, streamline care coordination, Local chapter of PDA (Parenteral Drug C CSU Ventures, Inc. reduce costs and improve clinical outcomes. Association) the leading global provider of science, technology and regulatory information Fort Collins C Fitzsimons Innovation Community and education for the pharmaceutical www.csuventures.org Aurora and biopharmaceutical community. CSU Ventures, Inc. (CSUV) is a 501(c)(3) non- www.fitzsimonsinnovation.com profit corporation that actively supports Offers a range of opportunity to life sciences RM ISPE (Rocky Mountain Chapter of and promotes the transfer of Colorado State research and development companies of International Society of Pharmaceutical University (CSU) research and innovations all sizes, from small start-ups to established Engineers) into the marketplace for the benefit of industry leaders. Within the campus, more www.ispe.org/rockymountain society. CSU Ventures serves CSU faculty than six million square feet of corporate The Rocky Mountain Region is among the and researchers who wish to protect and bioresearch facility space are being fastest growing biotechnology/pharmaceutical and license intellectual property; builds developed for companies and firms focusing communities in the nation. The chapter was relationships with industries and investors on the science and technology sectors. established in 1996 to accelerate the awareness seeking to engage with CSU; and leverages From cutting-edge lab facilities to advanced and visibility of the biopharmaceutical and CSU innovation to foster business formation technical support systems, everything at the medical device community through networking and enhance regional economic vitality. Fitzsimons Innovation Campus is designed and educational opportunities. The strengths C Morgan Adams Foundation specifically for the life science industry. of the chapter are visible with its large user involvement and the depth of technical Denver FRaBSA (Front Range Biological Safety programs provided. National speakers are www.morganadamsfoundation.org Association) invited often to share current trends and other The Morgan Adams Foundation helps fill www.frabsa.org relevant technical material to the chapter. the gap between the limited pediatric Local affiliate chapter to International ABSA cancer research dollars available and critical (American Biological Safety Association). RMRCSQA (Rocky Mountain Regional Chapter projects that might otherwise go unfunded. Focus is promoting the principles of biological Society of Quality Assurance) By providing seed, bridge gifts and grants safety and providing a forum for dissemination www.rmrcsqa.org for research exploring more effective and of information. Membership includes EH&S SQA is an association of over 2,200 QA less-toxic therapies for the treatment of officers at universities, government, industry professionals who are dedicated to pediatric cancers, we are funding hope. and service providers that support their needs. implementing Good Clinical Practices (GCPs), C Good Laboratory Practices (GLPs) and Good University of Colorado Office of Advancement i2sl Colorado Chapter Manufacturing Practices (GMPs) in industry, Aurora, Boulder, Colorado Springs www.i2sl.org/globalcommunity/chapters/ governments, academia and consulting. www.cu.edu/advancement colorado.html The University of Colorado Office of The I2SL Colorado Chapter seeks to be a RMRAS (Rocky Mountain Regulatory Affairs Advancement collaborates with faculty, staff, local resource and community for high-tech Society) benefactors, alumni and friends to raise laboratory and data center users, builders, www.rmras.org private support for the university by matching and suppliers. The chapter offers quarterly The Rocky Mountain Regulatory Affairs Society the passions of benefactors with the needs, and annual meetings focused on technical (RMRAS) is a non-profit organization for priorities and goals of each campus. topics, visiting built projects, and meeting professionals involved in the regulation of with like-minded individuals to collaborate medical devices, pharmaceuticals, biologics, and develop further ideas for the industry. and nutritional products. Our vision is to COMMUNITY PARTNERS advance the understanding and practice of worldwide medical Regulatory Affairs for ASQ (American Society of Quality) members in the Rocky Mountain region. www.asq.org/perl/section_list.pl?Colorado ASQ is a global community of people passionate about quality, who use the tools, their ideas and expertise to make our world work better. ASQ: The Global Voice of Quality. C Boomtown Boulder www.boomtownaccelerator.com An innovative and effective start up accelerator with a strong curriculum, excellent mentors, and a leadership staff that is passionate about what they do. All of this is centered within Boulder, CO, which has a higher concentration of startups than anywhere else in the U.S.

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