Directory Sequel Ventures of Colorado Sierra Neuropharmaceuticals Bioscience Taligen Therapeutics Companies Page 6

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The Money Game Hear From Barofold ARCA Biopharma Directory Sequel Ventures of Colorado Sierra Neuropharmaceuticals Bioscience Taligen Therapeutics Companies Page 6

& Resources Page 38 Colorado’s Bioscience Industry By the Numbers Page 12

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In 2004 we published the first Bioscience Colorado magazine. The industry has evolved quite a bit in the last four years. Since 2004, some 150 new companies were created. At the same time, many firms merged or were acquired. Also, Colorado’s research institutions have increased the number of 33 company spinouts five-fold since 2004. All Colorado Invests this activity has brought the industry to the in the Biosciences attention of state and local policy-makers, who are working to build the state’s bioscience cluster. As a byproduct, we’ve seen the development of an active industry association. 35 As you can see from the magazine Health care without directory (Page 38), there are now 430 borders: Colorado bioscience companies involved in Colorado companies the development of biotechnology, medical devices and bio-fuels. Colorado’s companies share medical are developing products for the pediatric treatments population, for baby-boomers, to solve global worldwide health problems and as diagnostics. Welcome to the 2008 edition of the Bioscience Colorado magazine. We hope 18 you enjoy it. Healthy at any age: 37 Baby boomers’ lust for Colorado Science and 6 life drives health-care Technology park at The Money Game: innovation in Fitzsimons Boosted by Cffbè^]fiXgcXZ\kfcfZXk\XY`fjZ`\eZ\ZfdgXep6 Seasoned entrepreneurs Colorado Private Investment and Public Science Glkljle[\ik_\d`ZifjZfg\% share insights into how they raised funds 22 Colorado knows how 38 10 to grow the bioscience Bioscience Companies Healthy kids, happy kids industry: and Resources Colorado companies nine new companies Directory Boost children’s health formed with $2 million through treatments, grant program supplements 74 The future of 30 bioscience: 12 Diagnosis as cure: executives share their Colorado’s Bioscience Methods for finding thoughts Industry: By the disease often provide Numbers treatment as well Metro Denver is home to some of America’s top university laboratories and research centers including the country’s largest medical-related development – the $4.3 billion Fitzsimons Life Science District. Ranked fifth in the nation for science and engineering graduate students, we offer bioscience companies access to knowledge workers, venture capital, and incubators. Not to mention an enviable lifestyle that helps retain our highly-skilled workforce. Examine us closely at www.metrodenver.org/bioscience. You’ll find that Metro Denver is well positioned for the future of bioscience. BIOSCIENCE COLORADO 5 BIOSCIENCE + INVESTMENT Seasoned entrepreneurs The Money Game: share insights into how they raised funds

EDITED BY RACHEL BRAND

f bioscience entrepreneurs have one thing in common, it’s a concern Iabout money. Who to ask for it, how to raise it, how to structure the deal and how to make the funds last. Fortunately, Colorado entrepreneurs can tap into a tight-knit community of local bankers, angel investors and venture capitalists. Here, company founders Dr. Michael Dan Mitchell Dr. Michael Bristow Dr. Dan Abrams Dr. Woody Emlen Dr. Lyndal Hesterberg Bristow, Dr. Dan Abrams, Dr. Mitchell: The first question is, what is the There were other investors there. off on the timing to explore more of a platform Mitchell: Here’s another issue: there are funds investors with deep pockets, that would be the Woody Emlen and Dr. Lyndal most effective way to get in front of investors? Bristow: In Colorado, we have this core group of concept. And that’s unusual because the more that are really big. And they can write really, best. You get your input, but you don’t have Hesterberg talk with venture Particularly VCs? VCs. Once they realize you’ve got something that typical response is, “how quickly can you get really big checks. On the one hand, you don’t to go out every three months and start raising capitalist Dan Mitchell and BRISTOW: The best way is to try to network and work may have some potential they — people like Dan — to market?” have to go to three people; you can go to one money again. Chris Shapard of the Colorado through any contacts that might have contacts with can make it happen. Hesterberg: Is this due to your particular for most of your money. On the other hand, Bristow: In this business, the first company Bioscience Association about the VCs. I think cold calls and sending a plan de Mitchell: Next, what are one or two things that you investors? you’ve got somebody who is really going to that you do is a bear and you spend a lot of raising funds. Each founder has novo is, I don’t want to say a waste of time, but very think got investors interested in your deal? In terms Emlen: Everything is related to particular dominate. They put two people on the board time on financing. With Myogen, on Series C, recently raised or is raising a unproductive. of where the molecule was, or time-to-market. How investors. I mean that every investor has his or instead of one. And you get much more we must’ve been in front of 50 companies. It significant sum of money. Mitchell: Do you find that getting a certain board did you control investor interest? her own preferences. direction about how to run your company. was unbelievable. But now people come to us. member or another entrepreneur to call versus a VC Hesterberg: For us, it was a clearly differentiated Bristow: It just depends on what’s happened Is there a net plus or a net minus for having We have to actually turn them down. So it gets – is there any difference? pharmaceutical product with a pretty rapid time-to- to them and what they need in their portfolio. investments from funds that big? a little easier as time goes on. “The best way is Bristow: The right person is important. It should be market. Literally, from the time the first Series A Maybe they just brought in some new partner Hesterberg: I’d rather deal with the Hesterberg: What I like about having multiple someone who really knows the VC, who the VC has preferred came through, our product was on market and have some special interest. management challenge of more funds and more investors is that in the ideal world, they’re all to try to trust in, who has made money for the VC before. in four years. That was very attractive. Shapard: Do you guys know ahead of time individuals than giving one person, no matter close to the same percent ownership. That network and Abrams: For me it worked the best through a Abrams: People did respond pretty positively to the if the investors are going to point you in one how correct they think they are, that kind of forces, at the board level, a business rationale presentation. So the issue becomes, what’s the fact that even though ours was an early concept, direction or another? control. to drive the company, as opposed to a single work through timing to go in front of prospective investors? the time to full development was fast. Also I think Emlen: In my experience, you get as many Bristow: There’s safety in numbers. fund’s internal issues and priorities driving it. any contacts And it works well for us to use the state-sponsored the fact that it was a platform technology attracted different responses as you present to different Hesterberg: Absolutely. Plus, there’s some And then it’s important to have non-VC competitive grants as a way of introducing ourselves interest. investors. balancing influences in it. These paths that board members to provide a little sanity too. that might have to the local venture investors. Mitchell: That’s interesting because the whole Hesterberg: It’s hard to read in advance. we’re on are not exactly cookie-cutter. Mitchell: What about corporate, or non-VC, contacts with Bristow: Once you get in front of the VCs for a concept of platform technologies comes and goes. Emlen: I believe that, with a few exceptions, Bristow: It never goes exactly the way you lay investors? presentation, you’ve already gotten past the first Bristow: A recently-published article said that with you can learn a lot from each presentation it out. Hesteberg: We’re thinking about that. We’ve the VCs.” hurdle. So any mechanism that will allow that to the right science on the right fundamental platform, you do. Emlen: I agree that it’s good to have different been approached by a couple and while happen efficiently is a good thing. it’s still a good play if you pick your spots and you Bristow: It’s like submitting a grant 20 times. board members and multiple investors and they would swallow our current valuation, Dr. Michael Bristow Shapard: For entrepreneurs who are just starting are capital efficient. If you’re a scientist, you submit lots of grants. different input. But on the other side of the they weren’t thrilled with it. They required out, are there any other ways to get the contacts? Emlen: The typical response by investors is they Each time I do it the grant gets better. And coin, raising money takes a huge amount of having one of their corporate officials on our Emlen: The presentation that Dan mentioned worked want something from us monthly. But we have sometimes it’s just a matter of making your time, and if you can get investors who put more board and access to all our information. One for us. We went to a local investor, and he helped some unique science that has broad applications. presentation or your business plan better, so money in, you can potentially allow yourself to company said, “We’d love to invest, but here’s get us in front of the proof-of-concept committee. Investors, much to our surprise, wanted us to back that the tenth time through you get funded. do more development. If you could get multiple our deal, we’ll put X amount in, but we want

6 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 7 one of our guys in there to have access to to include that in their first round? you had more investors than you needed, and couple of cases have theirs overlapped with ours. Bristow: It can work. You get a step up if you Hesterberg: I probably shouldn’t say this, but all your data.” I said no. They wanted voting Hesterberg: It’s another viable avenue. you had to go back and say that you can’t have Bristow: That’s true. They have their favorites. hit a milestone. Presumably you create value I don’t think the biotech investment world is powers. Bristow: At ARCA, we ended up on a B a board seat – did you have that discussion Which could be a problem. You need to know by reaching that milestone. On the other hand, beating a path to the Denver and Boulder area. Emlen: It may be company-specific because we round in front of half a dozen cross-over and with people? who those favorites are. if there’s some chance you’re not going to You’ve got to go out and get it, in other words, almost had a deal with a large company. And hedge funds. All of them are willing to invest. Emlen: Yeah, we did, and the investors bowed Emlen: You need to make sure that the key meet the milestone or you forget to meet the go to the coast to build the networks to get they were satisfied to have observer rights only Basically, they gave the same terms as VCs. out. opinion leaders that you recommend the milestone… the introductions to get the investors to come and be in the room only at appropriate times. So we stayed with VCs, primarily because we Mitchell: Out of the round? investors talk to — they’re well-coached and Emlen: The VC’s aren’t stupid and are back to this area. It’s a lot of work. We’re still When it came time to have an exit strategy, we thought we could get more help developing Emlen: Yes. familiar with your technology and believe in it. basically mitigating their risks. Do you disadvantaged. potentially had a good acquisition partner. We the company. The cross-over funds want to just Bristow: Typically, in the early rounds, if they Because investors will also go outside to their frequently do deals that are not tranched? Bristow: I don’t buy that. I just absolutely ended up not going with them. put the money down and not play an active have a significant piece of the company, they own people. So take care of the people you Mitchell: I do it both ways. I’m willing to take don’t buy that we’re disadvantaged here. Bristow: It can make sense to partner certain role in company development. Their value is want a board seat. And if you don’t give them refer them to; warn them ahead of time before more risks than some folks because I know Emlen: Investors, I think, very clearly and compartmentalized components of your when you’re headed for the IPO. They know a seat, it probably means you don’t want them a call. That’s really important because one call the hassles of having to go back to the well in quickly differentiate themselves as to whether operation. No company has just one asset. the company, and they are in on the IPO buy. on the board. goes wrong, you’ve lost an investor. the middle of something. If you’ve got really they are willing to invest in Colorado. For example, at Myogen with our pre-clinical Early though, staying with VCs probably Mitchell: It might also mean that you’re Bristow: Don’t leave it up to chance. clear milestones, I guess it can make sense. If Bristow: Exactly. partner Novartis we offloaded a huge amount makes the most sense. But it would depend on raising a big round, and you’ve got two people Abrams: I’m hoping that we can simmer it you get enough people at the table, though, I’d Emlen: And probably 25 percent of them won’t of the pre-clinical and R & D work. That was the cross-over fund and the person involved. committed, and you’ve already got seats down to the two key opinion leaders that we rather put all the money in and get to work. do it. Again, don’t waste your time. So if you a really good thing. But that deal didn’t touch And they are certainly smart, no doubt spoken for, and you still need another ten think are the most interested in the technology. Emlen: That would be nice, but I think that’s take that 25 percent out, that’s something of a the later stage drug development business, so about it. million. You’re going to face that problem. But I don’t want to burn them out. I’m being unusual. disadvantage. But there’s still plenty out there. it didn’t hurt us at all. Bristow: Then make a bigger board. protective of them until I’m sure on the other Abrams: Our seed deal was tranched for a Shapard: Do you guys go to European or Abrams: I thought you meant something Mitchell: How big is ARCA’s board? side there’s a high level of interest. series A. So far I haven’t seen a problem, and Asian investors at all? different by that question. We’ve chosen Bristow: Our current board is nine, and Emlen: That’s appropriate, because they can it was a way to move the seed deal along with Hesterberg: We didn’t, but the Europeans other people with start-up expertise and CEO “I’d rather deal with that’s about as big as it ever needs to be. As easily get burned out. high-quality investors. are coming to us at this point. It’s been very expertise for our board in order to guide the the management chairman, it’s a lot of work to manage all that. Mitchell: What do you think about getting Hesterberg: It depends on where your surprising. The exchange rates are so favorable company. At least at this stage we thought it It should never hit double digits. financing in tranches, tranching your deal? company is at in development. If there’s really now to the euro. was a very important addition. challenge of more Emlen: There’s a significant energy and Emlen: Every investor that you talk to is a discovery component to your work, I would Mitchell: There’s also phenomenal lack of Bristow: Board composition is very funds and more in- activation to getting a lead investor because, talking about tranching. It’s simply the norm. avoid tranching. If the company is ready to liquidity with deals in Europe. important. In a perfect world you’d have with all due respect, VCs are a little like You just need to make sure that the milestones execute, where you already know the path Shapard: How do you all feel about the IPO some kind of combination of management dividuals than giv- lemmings. We have a lot of people who are clearly executable and well laid out so you and deliverables, then I’m comfortable with market these days? on your board — one or two slots — as well are sincerely interested but waiting on the don’t trip yourself up. But if you communicate tranching. Bristow: Could be better. Right now it’s still as VCs and independents. VCs will be there ing one person, no sidelines until someone jumps. So getting that well during the due diligence process, it Mitchell: Well, anything else? I think we kind on the downside, but you can still get out with regardless, so that will be two to four of your matter how correct first person to step up can be very difficult. In shouldn’t be a problem. of hit all the main points on fundraising. really good stuff. board slots. And then independent numbers our case, we did this without a formal term are really critical, those with expertise in what they think they are, sheet. We got a non-binding letter from one you’re trying to do. It’s nice to have a mixture that kind of investor. And it moved things along. Then it of those three worlds. And it’s also nice to turned out that investor didn’t come into the outnumber the VCs with management and control.” round. That first investor was just a catalyst. independents. Abrams: It’s too bad investors can’t make Dr. Lyndal Hesterberg Mitchell: In Colorado, there’s a lot of talk money just doing that. It would be a great about trying to build up the angel community. business. Any experience with angel investors? Bristow: Again, this is really where local Bristow: It depends on the definition of Mitchell: Here’s a touchy question: What did venture capital firms can play an important angel. It’s really great to have people around you feel was best to get people to move to the role. Local VCs have a better opportunity to who have started companies before, who next step? It’s really difficult to get a sense of know and evaluate us; they can dig deeper on will work for sweat equity, and then take urgency around deals. Any tricks or advice for their due diligence. They also have a vested something in series A or some common stock entrepreneurs? interest in something happening locally. So for their efforts. In that scenario, founders Bristow: What always works is, “if you don’t if you can get a local VC to go in, you are can shoestring or bootstrap the company get in this now you’re not getting in.” halfway there, if not 90 percent there. It’s then along because it doesn’t take much capital. Emlen: You just need to keep after people, and just a matter of time recruiting other VCs. Roche What’s harder is to find somebody who’ll you’ll know pretty quickly whether they’re That’s how Myogen and ARCA got done by Colorado actually work at this and knows how to do really serious or not. And if they’re not, don’t leveraging local influence. NOT ALL PEPTIDES ARE CREATED EQUALLY. it, in exchange for equity in the company. If waste your time there. But if you can generate Mitchell: Dan Abrams and I are currently in you call those angels, I think they are very competition, that’s great, but that can be the middle of the Sierra Neuropharmaceuticals We have unique chemistries to solve customer needs important. difficult to do. raise. We’re talking to a lot people, and all of Abrams: Some angels offered us expertise and Bristow: The A round is always the high them want access to our KOLs (key opinion for aggressive cost-of-goods targets. assistance in management, which we could threshold round. But if you can do that, then leaders – i.e. physicians who are on your 303 938 6564 | www.RocheColorado.com/peptides take or not take as we went along. It wasn’t things move pretty quickly. In later rounds, if board). Those are very important relationships. necessarily the money, but it was the education, you have VCs who are stepping up on the next I was wondering, though, how do you manage the involvement and the Rolodex. round then they can basically say, hey look, if that? Because I’d rather not have 15 different Join us for the Roche Colorado Peptide Symposium 2008 Mitchell: What about the other end of the you don’t get this now I’ve got this guy, this people calling my thought leaders at different spectrum? What about cross-over funds and guy, and this guy ready to go. You know people institutions. September 11 —12 in Boulder, Colorado hedge funds? I’m finding there are pretty are pretty straight forward reacting to that kind Hesterberg: It hasn’t been an issue. In fact, for www.RocheColorado.com/PeptideSymp08/rccps08 smart people in hedge funds and cross-over of information. the very specific targets that we’re going after, funds. Would you tell someone starting today Mitchell: Have you ever had a problem where they have their own stable of experts. In only a

8 BIOSCIENCE COLORADO BIORC-231SCIENCE RCCPS_Ad_6.indd COLORADO 1 4/3/08 5:10:57 PM 9 BIOSCIENCE + CHILDREN “In the 1700s, our cows “Kids’ brains develop most rapidly used to graze in the fields,” he while they are in the womb,’ says Bill says, “and they would get the precursors to DHA. But when Barkley, Martek Biosciences Corp.’s we mechanized agriculture and chief intellectual property officer. made food cheap by feeding our “But up until age 12 there’s still cattle corn, we took out those precursors to DHA. You believe significant growth of the brain.” it can do so much good if you Healthy kids, happy kids can get into the diet, where it a shot once a week or less. productive organisms,” Barkley used to be naturally.” The company has completed a says. “We know how to trick Other research into cures number of pre-clinical toxicology them to make just the compound for pediatric illnesses is tests and is raising the $250,000 we want and to make large taking place in Colorado at to $500,000 needed to get the amounts of it.” the Children’s Hospital. product into Phase I clinical The 525-employee company Affiliated with theUniversity Colorado companies trials. “The goal is to get it into was founded in 1985 when of Colorado Denver School the clinic fourth quarter 2008 or aerospace giant Martin Marietta of Medicine, the Children’s first quarter 2009,” Cox says. began studying the beneficial use Hospital has pioneered research Despite the fact that he’s of algae in long-term space flight. in the treatment of pediatric Boost children’s health working on an orphan disease, Headquartered in Columbia, Md., liver disease, infectious Cox thinks the market will Martek gained a research facility disease and vaccines, pediatric embrace Bolder BioTechnology’s in Boulder in 2002 when it bought and adolescent HIV/AIDS, through treatments, product. Boulder-based OmegaTech, which cystic fibrosis, pulmonary “What child wants to have had also been deriving DHA hypertension, pediatric to take an injection every day?” from algae. cardiology and neonatology . Cox asks. “We think a lot of Barkley, based at the Boulder Other Colorado companies supplements children would like to switch facility, has been working on the working on improving pediatric to an easier way to take the technology for 25 years and is health care include Replidyne hormone.” still excited by the research and Inc., Cochlear Americas and It doesn’t take an illness to its promise for healthy children. Roche Colorado. stimulate pediatric health-related research and development. Martek Biosciences Corp. seeks to enhance children’s health by BY CARON SCHWARTZ ELLIS because (the garments) calm incorporating DHA from a novel odern vaccines allow “What child wants to have to down their sensory input.” source into infant formula and most children to take an injection every day?” Bolder BioTechnology Inc. toddler foods. Docosahexaenoic avoid what used to be asked Joe Cox, CEO of Bolder is tackling an even lesser-known acid, known as DHA, is a common killers: polio, illness — pediatric growth polyunsaturated omega-3 fatty M BioTechnology Inc. hormone deficiency, which acid found throughout the body. measles and whooping cough. And with medical advances, affects some 10,000 to 15,000 It is a major structural fat in the vaccines are helping American March of Dimes. To alleviate improves patient posture and children in the U.S. The disorder, brain and retina and is also a key kids forgo unpleasant, less lethal these disorders and other enhances sensory input. Since which can lead to abnormal component of the heart. disorders such as rotavirus and neuromotor problems, pediatric the company was founded, growth and muscle development, “Kids’ brains develop most even the common flu. physical therapist Beverly TheraTogs are now used by stems from a disruption in the rapidly while they are in the While that’s great news for Cusick and her husband, Lee thousands of physical and production of certain hormones. womb,’ says Bill Barkley, Martek’s the battle against infectious Taylor, launched TheraTogs occupational therapists. The gold-standard treatment chief intellectual property diseases, the frontier of pediatric Inc. in 2006. Some occupational therapists is daily injections of growth officer. “But up until age 12 medicine has moved to rarer TheraTogs are an orthotic even use TheraTogs to treat hormone for five to 10 years, or there’s still significant growth illnesses. And a number of undergarment system made of children with autism. Taylor until, as a teenager, the child stops of the brain. DHA is very Colorado companies are working water-based, millimeter-thick recalls how one therapist tried growing, says Joe Cox, president important in the structure and on treatments in this area. urethane foam that’s “breathable a TheraTogs tank top on a little of the Boulder-based company. nerves junction of the nerves, Spina bifida, a complex and much more comfortable girl with autism, and she was Bolder BioTechnology is and also for eye health.” neuromuscular birth defect, than traditional orthotics,” CEO suddenly able to write her name. developing a highly potent, Martek isn’t unique in affects as many as 70,000 Taylor says. “In many of those kids’ long-acting growth hormone promoting DHA in children’s Americans, according to the Clinicians attach a customized cases, part of their difficulty using the company’s PEGylation diets, but what is unusual is Pharmaceutical Research & Manufacturers of America Spina Bifida Association. And system of straps to the foam, and is they don’t process sensory technology, which extends the its source; while most DHA Disease is our enemy. Working to save lives is our job. two to three children per 1,000 the outfit operates like external input as effectively as someone half-lives of proteins. Because supplements are derived from have cerebral palsy, a group of muscles, positioning patients outside the autism spectrum,” of its extended half-life, Bolder fish oils, Martek’s process chronic movement or posture properly throughout the day. The Taylor says. “They are trying to BioTechnology’s modified extracts DHA from algae, fishes’ disorders typically caused by system reduces kinesiological find their body in space. (They) growth hormone lasts longer original source. birth trauma, according to the and biomechanical errors, benefit from wearing TheraTogs once injected, so kids only need “Algae are incredibly

10 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 11

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Publicly traded companies with headquarters or Colorado’s operations in Colorado Colorado Colorado Global Company Name Exchange Symbol Colorado Products Location Employees Employees Instrumentation for medical diagnostics; basic research and Accelr8 Technology Corp Denver Amex AXK 10 * 33 drug discovery Bioscience The number of publicly AcuNetx Inc. Louisville OTCBB ANTX Devices to treat balance disorders 4 * Agilent Technologies Inc., Boulder NYSE A Turn-key therapeutic oligo development 50 19,400 Industry: traded Nucleic Acid Solutions companies Allos Therapeutics Inc. Westminster Nasdaq ALTH Treatments for lymphoma and non-small cell lung cancer 59 * headquartered Alpharma Animal Health Inc. Longmont NYSE ALO Animal and human pharmaceuticals 17 1,400 Boulder, Therapeutics for supportive cancer care, nephrology, By the or with Amgen Inc. Nasdaq AMGN 1,250 16,500 Longmont inflammation and oncology operations in Array BioPharma Inc. Boulder Nasdaq ARRY Small molecule drugs for cancer and inflammatory disease 320 * Numbers Colorado Aspen BioPharma Inc. Castle Rock Nasdaq APPY Diagnostic tests, primarily for the veterinary markets 20 * Ceragenix Pharmaceuticals Topical cream-based treatments for infectious disease and Denver OTCBB CGXP.OB 5 * Inc. dermatology Celgene Corp. Boulder Nasdaq CELG Treatments for multiple myeloma and other cancers 60 1,600 Australian Cochlear Americas Englewood COH Cochlear implants 300 1,600 Exchange Every scientific researcher Designs and manufactures RF electrosurgical generators and Conmed Corp. Centennial Nasdaq CNMD 125 3,200 knows that while anecdotes are accessories compelling, data tells the real Diagnostic test kits for vascular diseases and immunological Corgenix Medical Corp. Broomfield OTCBB CONX.OB 43 5 story. In the case of Colorado’s disorders bioscience industry, the data Covidien AG Boulder NYSE COV Electrosurgery equipment; pulse oximetry and ventilators 1,000 43,000 Dharmacon, part of Thermo Lafayette NYSE TMO Novel technologies for RNA interference 130 11,500 is good. It shows that research Fischer Scientific Inc. institutions are spinning out new Encision Inc. Boulder Amex ECI Devices for minimally-invasive surgery 45 * companies at unprecedented Manufactures instruments that measure total organic carbon GE Analytical Instruments Boulder NYSE GE 175 327,000 speed. It proves that work done (TOC) in water in Colorado attracts international Gilead Sciences Inc. Westminster Nasdaq GILD Treatments for pulmonary arterial hypertension 65 2,900 investment. And it confirms that Heska Corp. Loveland Nasdaq HSKA Advanced veterinary diagnostics 300 N/A our bioscience companies have Hospira Inc. Boulder NYSE HSP Manufactures specialty injectible generic pharmaceuticals 100 15,000 a robust pipeline of drugs and Insmed Inc. Boulder Nasdaq INSM Specializes in protein drug development 80 160 Subsidiary InB:Hauser Pharmaceuticals Inc. extracts and devices in clinical trials. Integrated BioPharma Inc. Denver Nasdaq INBP 35 167 purifies products from plant, marine and microbial sources Subsidiary InB:Paxis Pharmaceuticals Inc. manufactures Integrated BioPharma Inc. Boulder Nasdaq INBP 15 167 While we don’t pretend to scientific and markets generic paclitaxel accuracy in compiling the lists Martek Biosciences Corp. Boulder Nasdaq MATK Develops nutriceuticals from microalgae 30 515 that follow, we are beginning to Medtronic Inc. Louisville NYSE MDT Manufactures surgical navigation devices and hardware 300 38,000 benchmark the industry’s growth. Mesa Laboratories Inc. Lakewood Nasdaq MLAB Manufactures dialysis clinical supplies 100 * Discovery and development of oncology, diabetes and eye Read the story by the numbers. OSI Pharmaceuticals Inc. Boulder Nasdaq OSIP 135 550 disease theraputics Discovery and development of dermatology and QLT Inc. Fort Collins Nasdaq QLTI 25 240 opthalmology treatments Replidyne Inc. Louisville Nasdaq RDYN Discovery and development of anti-infective products 50 4 Swiss Roche Colorado Boulder RHHBY Small-peptide manufacturing plant 340 74,000 Exchange Division of Novartis that manufactures generic drugs, Sandoz Inc. Broomfield NYSE NVS 600 98,200 particularly anti-infectives and anti-arthritics The Sorin Group Arvada Milan SRN.MI Therapeutic solutions in the treatment of cardiac disease 250 4,500 Exchange Spectranetics Corp. Colorado Nasdaq SPNC Medical devices for minimally invasive cardiac surgery 300 16 Springs

*All employees are located in Colorado Source: CBSA Research

12 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 13 Colorado companies with pharmaceuticals in FDA clinical trials

Company Product Medical indication Phase Accera Inc. Ketasyn Mild-to-moderate Alzheimer’s disease I/II Lung cancer, in combination with chemotherapy and Allos Therapeutics Inc. efaproxiral III 20 radiation The number of local drug and Allos Therapeutics Inc. pralatrexate Relapsed or refractory cutaneous T-cell lymphoma I/II device companies with products in Allos Therapeutics Inc. pralatrexate Non-small cell lung cancer patients II clinical trials Allos Therapeutics Inc. pralatrexate Relapsed or refractory lymphoproliferative malignancies I Allos Therapeutics Inc. RH-1 Advanced solid tumors or non-Hodgkin’s lymphoma I Amgen Inc. Aranesp Chronic kidney disease, anemia, and type 2 diabetes III Amgen Inc. Aranesp Anemia in heart failure III Amgen Inc. Denosumab Prevention of bone metastases III Bone loss induced by hormone ablation therapy in breast Amgen Inc. Denosumab III cancer or prostate cancer Prevention of cancer-related bone damage in breast cancer, Amgen Inc. Denosumab III prostate cancer and solid tumors Amgen Inc. Denosumab Postmenopausal osteoporosis III Amgen Inc. Denosumab Multiple myeloma II Amgen Inc. Denosumab Rheumatoid arthritis II Colorado companies with medical devices in FDA clinical trials Array BioPharma Inc. ARRY-142886 Cancer I Company Product Study purpose Phase Array BioPharma Inc. ARRY-334543 Solid tumors I To compare P-15 bone putty to DBX in patients with degenerative disk CeraPedics Inc. P-15 bone putty IV Array BioPharma Inc. ARRY-380 Breast cancer I disease Array BioPharma Inc. ARRY-520 Advanced leukemia I/II To compare the safety and efficacy of using a vascular sealant with Covidien AG Vascular sealant I Array BioPharma Inc. ARRY-520 Neoplasms I Gelform/Thrombin in vascular reconstructive surgery To compare and contrast the Polyflux HD-C4 dialyzer with the Polyflux Array BioPharma Inc. ARRY-797 Pain relief during molar extraction surgery II Gambro Polyflux HD-C4 interventional 210H dialyzer in routine dialysis Array BioPharma Inc. ARRY-886 Advanced melanoma II To determine if the performance of a dialyzer depends on how tightly the Gambro Polyflux HD-C4 interventional Biodesix Inc. VeriStrat Non-small cell lung cancer III hollow fiber membranes are packed Neurolex EEG-based ADHD To examine the predictive ability of EEG in diagnosing patients with bioNovo Inc. BZL101 Advanced breast cancer I/II Lexicor Medical Technology LLC observational Assessment Aid ADHD bioNovo Inc. VG101 Postmenopausal vaginal atrophy I/II INFUSE bone graft/PEEK To determine the safety and effectiveness of these products in patients with Celgene Corp. (formerly Pharmion Medtronic Navigation III MGCD0103 & Azacitidine Lymphoma II Spacer/Anterior Cervical plate symptomatic cervical degenerative disk disease Corp.) To establish the safety and efficacy of the DIAM Spinal Stabilization DIAM Spinal Stabilization Celgene Corp. (formerly Pharmion Medtronic Navigation System in the treatment of moderate, single-level lumbar degenerative disc III thalidomide MALT lymphoma II System Corp.) disease Celgene Corp. (formerly Pharmion A-MAV Anterior Motion To collect safety and efficacy data about A-MAV as a treatment for patients Vidaza Myelodysplastic syndromes (MDS) III Medtronic Navigation III Corp.) Segment Replacement with lumbar degenerative disc disease Metastatic cancers to the brain originating from breast, lung, To assess the safety and efficacy of using MAVERICK Total Disc DMI BioSciences Inc. DMI-3934 II MAVERICK Total Disc melanoma, kidney or colon cancers Medtronic Navigation Replacement as a treatment for patients with lumbar degenerative disc III Replacement disease Macular degeneration, diabetic retinopathy and diabetic DMI BioSciences Inc. DMI-5207 I edema To assess the safety and effectiveness of using PRESTIGE LP as a Medtronic Navigation PRESTIGE LP III treatment for patients with symptomatic degenerative disc disease DMI BioSciences Inc. Zertane Premature ejaculation III To assess the long-term effectiveness of using the PRESTIGE Cervical Disc Medtronic Navigation PRESTIGE LP IV Gilead ambrisentan Pulmonary arterial hypertension II/III in the treatment of patients with cervical degenerative disc disease GlobeImmune Inc. GI-4000 Non-metastatic pancreatic cancer II To establish the safety and efficacy of the BRYAN R Cervical Disc in the Medtronic Navigation BRYAN R III GlobeImmune Inc. GI-5005 Hepatitis C II treatment of single-level degenerative disc disease of the cervical spine Otologics fully-implantable OSI Pharmaceuticals Inc. OSI-906 Advanced solid tumors I Otologics LLC To test its direct cochlear stimulation prosthesis II hearing device OSI Pharmaceuticals Inc. OSI-930 Advanced solid tumors I To evaluate the safety and efficacy of the CLiRpath Photoablation CELLO - CLiRpath Excimer OSI Pharmaceuticals Inc. Tarceva Non-small cell lung cancer III Spectranetics Atherectomy System to create larger lumens for treatment of arteries above III Laser System the knee OSI Pharmaceuticals Inc. Tarceva Ovarian and colorectal cancers III To assess if using excimer laser coronary atherectomy before stenting leads Spectranetics Laser Thromoablation II QLT Inc. Aczone Rosacea II to improved reperfusion rates QLT Inc. GHRP End-stage renal disease II Synthes Reamer-Irrigator- To compare the quantity of fat released into the blood by reaming the Synthes Inc. interventional QLT Inc. Lemuteporfin Severe acne I/II Aspirator (RIA) femoral canal using two different reaming systems

QLT Inc. Lemuteporfin Acne I Synthes Reamer-Irrigator- To study the composition of bone graft harvested during the RIA system in Synthes Inc. interventional QLT Inc. Visudyne Age-related macular degeneration II Aspirator (RIA) orthopedic trauma patients

Source: www.clinicaltrials.gov; company Web sites Source: ClinicalTrials.gov; company Web sites 14 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 15 Companies founded since 01/01/2006 Company Founder or Key Researcher Technology and product

A2BE Carbon Capture Jim Sears, Jim Mettais and Developing ways to capture and recycle carbon dioxide 33 LLC Mark Allen The number of new companies Accuthera Inc. John Cheronis, M.D. Developing compounds for the treatment of sepsis-related inflammation Advanced Headache spin-off from Advanced founded in Developing medical devices for the treatment of migraine headache Intervention Inc. Cosmetic Intervention Colorado in the $2.9 Advanced Microlabs Dr. Charles S. Henry Analytical instruments last two years ApopLogic Richard Duke, Ph.D. and billion Developing therapies that target apoptotic cell death pathways in cancer cells Donald Bellgrau, Ph.D. The amount Celgene Corp. Pharmaceuticals Inc. paid for Colorado’s Pharmion ArcScan Inc. Ed Wood Developing a precision imaging system for the eye Beacon Biotechnology LLC Larry Lansing Developing a diagnostic platform Corp. in the biggest bioscience Biodesix Inc. David Brunel Developing mass spectrometry-based molecular diagnostics deal of 2007 Caveo Therapeutics Doug Graham, M.D. Developing products to treat hematological disorders Deals in 2007 and first quarter 2008 Chemizon Inc. Tony Piscopio, Ph.D. Provides drug discovery and development capabilities to the drug industry John Dunning and Jim Company Technology Deal Type Investor, Buyer, or Partner Value Clarimedix Inc. Developing devices to treat pain and other chronic health problems Brooks Underwriters: Merrill Lynch, Banc of Allos Therapeutics Inc. small molecule therapeutics to treat cancer Secondary offering $50.5 million America Securities, JMP Securities CycleGen Inc. Larry Gold, Ph.D. Developing methods of treating tumors through apoptosis Investors: Skyline Ventures, InterWest EndoShape Inc. Harold Tyber Developing shape memory polymer stents next-generation vasodilator and beta-blocker ARCA biopharma Inc. Series B financing Partners, Atlas Venture, Peierls Foundation, $18 million for heart failure Fluonic Inc. Amir Genosar Developing a disposable flow sensor for infusion therapy Boulder Ventures novel recombinant single-chain bovine Gordon Van Dusen and Aspen BioPharma Inc. Private placement Investors: new and existing shareholders $18.2 million Hiberna Corp. Identifying novel therapeutic targets for reversing metabolic disorders products Tom Marr, Ph.D. novel recombinant single-chain bovine Licensing Aspen BioPharma Inc. Licensor: Novartis Animal Health undisclosed Illumasonix LLC Robin Shandas, PhD Developing a non-invasive vascular disease detection procedure products agreement Susan Bailey, Ph.D., protein processing technology that Investors: HBM Bioventures, Peierls BaroFold Inc. refolds recombinant proteins at higher Series A financing $12 million Joel Bedford, Ph.D., Foundation, Boulder Ventures concentrations KromaTiD Inc. Ed Goodwin, Ph.D., Developing chromatid paints for the detection of chromosomal inversions Michael Kornforth, Ph.D., Ceragenix Pharmaceuticals EpiCeram, a prescription topical cream Milestone payment Partner: Dr. Reddy’s Laboratories $1.5 million Inc. Andrew Ray, Ph.D. products for the orthopedic bone substitute Lanx LLC Michael Fulton, M.D. Spinal and surgical equipment manufacturer CeraPedics Inc. Series A financing Investor: OrbiMed Advisors $12.3 million market Locomotion Inc. Rodger Kram, Ph.D. Developing rehabilitation and physical therapy devices Investors: Wexford Capital, Celgene Corp., mBio Diagnostics Chris Myatt Spinoff of Precision Photonics Corp. developing low-cost, high-sensitivity point-of-care diagnostics Mellon Family Investment Company, discovery and development of potent, GlobeImmune Inc. Series C financing Richard King Mellon Foundation, Eminent $41.2 million targeted molecular immunotherapies Miragen Venture Capital Corp., Boston Life Science Michael Bristow, M.D. Discovering treatments for cardiovascular disease by harnessing the power of microRNA biology Pharmaceuticals Inc. Venture Corp., WRF Capital Investors: 3i Group, Sequel Venture NanoDisc Inc. Michael Artinger, M.D. Developing a proprietary nanoscale platform for delivery, imaging and diagnostics Partners, Quest Capital Partnership, Hunt continuous real-time glucose monitoring Glucon Inc. Series D financing Ventures, Giza Venture Capital, MKI, undisclosed Ryan Gill, Ph.D. and technologies OPX Biotechnologies Inc. Developing a technology to rapidly conduct genome-level research Infinity Venture Capital Fund, Ascend Michael Lynch, Ph.D. Technology Ventures Peak Biosciences Inc. Stephen Warren Developing nanoscale radiotherapy products to treat advanced solid tumors an improved method for an orthopedic Investors: Sutter Hill Ventures, Skyline iBalance Medical Inc. Series A financing $13.5 million procedure called high tibeal osteotomy Ventures pico-tesla Magnetic Allen Braswell Using low electro-magnetic fields to treat Parkinson’s Disease Investors: Chicago Growth Partners, Therapies LLC Lanx LLC implants for spinal surgery Series A financing Goldman Sachs, Oakwood Medical $25 million Investors Pulmonex Inc. Julie Imig Developing a novel treatment for respiratory infections using technology to rapidly screen and Investors: Mohr Davidow Ventures, X/Seed Sierra OPX Biotechnologies Inc. modify microbes used in producing Series A financing $3.6 million Dan Abrams, M.D. Reformulating medications for placement into an implantable pump to treat diseases of the brain Capital Management renewable fuels Neuropharmaceuticals Inc. products to treat blood and solid tumor Snoasis Medical Inc. Robert Tofe Developing a soft tissue substitute for use in dental surgeries Pharmion Corp. Acquisition Buyer: Celgene Corp. $2.9 billion cancers Doug Henston and Investors: Passport Capital, BlueMountain, Solix Biofuels Developing massively scalable bioreactors to produce biodiesel from algae Range Fuels cellulosic ethanol Series B financing Khosla Ventures, Leaf Clean Energy Co., $130 million Bryan Willson, Ph.D. PCG Clean Energy and Technology Fund Tissue Genetics Inc. Jeff Holt, M.D. Developing a tissue-based protein truncation test for cancer diagnostics next-generation medical diagnostics based SomaLogic not available not available $35 million on protien signatures ValveXchange Inc. Ivan Vesely, Ph.D. Developing a two-piece bioprosthetic tissue heart valve continuous real-time glucose monitoring Investors: Alta Partners, Clarus Ventures, Ventrus Biosciences Inc. Thom Rowland Licensing and developing late-stage gastroenterology products Taligen Therapeutics Inc. Series B financing $65 million technologies Sanderling, High Country Venture, Tango Vitrumed Dave Schechter Developing medical devices with a focus on minimally invasive surgery Source: CBSA Research Source: CBSA Research

16 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 17 BIOSCIENCE + BABY BOOMERS Healthy at any age: The Tensegrity foot helps amputees walk more easily, for a longer period of time and at more Baby boomers’ lust for life drives than one speed. COURTESY TENSEGRITY PROSTHETICS INC. health-care innovation in Colorado

BY CARON SCHWARTZ ELLIS treated every year. GlobeImmune’s GI-5005 Tarmogen (Targeted Molecular Immunogen) is in Phase aby boomers are living longer than II clinical trials, with the first efficacy results previous generations, and they are expected at the end of 2008. The drug, which not satisfied by mere longevity. turns on the body’s immune response to get Matt Thornhill, founder of the rid of the virus, is given in addition to the B standard of care. Richmond, Va.-based market research firm The Boomer Project, dubs it “middle age GI-5005 can improve baby boomers’ of Aquarius.” The 78 million Americans lives in two ways, Christofferson says. “We circulation and fragile skin in the extremities. on medical device to help baby boomers with patient. You snap out the leaflets and avoid an born between 1946 and 1964 are not hope to take the current cure rate and raise “So with that combination of conditions if cardiovascular disease stay more active. hour and a half procedure where the patient is quietly transitioning to senior citizen status it significantly. But our ultimate goal is to you’ve got a really stiff carbon-fiber foot that ValveXchange Inc. holds patented on bypass.” like their parents did, rather, life over 50 reduce the amount of time patients need to be needs a lot of force to move, people can get technology on a two-piece bioprosthetic Vesely, a biomedical engineer, says he is “remains something that they want to make on interferon.” ulcerations and not feel it, and it makes the tissue valve that resolves the long-standing able to complete the surgery on animals in sure continues to be experienced – and, “GlobeImmune Inc.’s Tarmogens (Targeted As the obesity epidemic spreads across the condition worse.” compromises between conventional 26 seconds, and “doctors can do it faster in if possible, not just experienced well, but Molecular Immunotherapy) are whole, heat- United States, the incidence of complications Tensegrity’s foot bends like a normal foot mechanical and animal-tissue heart valves. humans,” performing the operation while experienced better.” killed recombinant S. cerevisiae yeast that express – particularly diabetes – increases as well. and ankle, conforming to the terrain being “Over the 40-year history of heart- the heart is beating using minimally invasive A number of Colorado companies one or more disease-related proteins. Tarmogens According to the Centers for Disease Control, walked on. It also provides greater stability, valve replacement bovine pericardium has surgical techniques. are developing medical devices and generate activated killer T cells capable of 10 percent of Americans aged 40 to 59 have and has a “big toe” to help with balance and established itself as one of the very suitable The primary benefit of the new valve is that pharmaceuticals to help make those 20 or 30 locating and destroying any cell with the same diabetes, and the number jumps to 20.9 agility. materials for heart valves,” says ValveXchange younger baby boomers will be able to get a years past retirement happier, healthier and disease protein.” Courtesy GlobeImmune Inc. percent in those 60 and over. Besides fitting and feeling better, the more founder and Chief Scientific Officer Ivan better heart valve that can be repaired rather more active. Colorado remains the country’s leanest life-like foot helps amputees walk more Vesely. “Over the years manufacturers have than replaced when it breaks down. Today Louisville-based GlobeImmune Inc. is Untreated, people with the disease will state and has a lower incidence of diabetes easily, for a longer period of time and at more tried to mimic the shape of the aortic valve younger patients don’t tend to choose a tissue developing a drug for a devastating disease typically have no symptoms until age 70, than other part of the country. But evidence than one speed. And that can have financial with bovine pericardium and a stent.” valve because it will need to be replaced in that many 50-somethings don’t even know when they might be diagnosed with cirrhosis shows that Coloradans are getting fatter, and implications, Rifkin says. A prosthetic foot In fact, Vesely says, the technology is so 10 or 15 years, meaning another open-heart they have — Hepatitis C. or cancer, Christoffersen says. the state may see an increase in cases of the that allows users do more than simply walk at good that ValveXchange “blatantly copied” surgery. So they opt for a mechanical heart “Baby boomers form the largest Today’s standard-of-care treatment endocrine system illness. a slow, steady pace will entitle the company the industry-leading Edwards Lifesciences’ valve, and it lasts the rest of their life. The population of chronic Hepatitis C,” says Kirk for Hepatitis C is a year-long regimen of Tensegrity Prosthetics Inc. is addressing to a higher reimbursement rate from their animal-tissue valve, which is now off-patent. problem is clots can form around the plastic Christoffersen, senior director of corporate interferon and ribavirin that prevents the one of diabetes’ side effects by developing insurance carrier or Medicare. “We don’t have to prove to the world that our device, and they need to take anticoagulation development for the Louisville-based virus from replicating. But it has severe side a medical device that should help baby The Tensegrity foot has been in clinical valve is better,” he says. medicine. company. “They turn 45, 50 or 55, and in effects including anemia, depression and flu- boomers with the disease stay more active – a trials for more than a year, and Rifkin says the Although the design is the same, the “Basically, you’re living the life of a a routine exam they discover by chemical like symptoms. better prosthetic foot. data is good. He’s working with Syncroness, ValveXchange version comes in two pieces – a hemophiliac – a really constrained lifestyle markers there is something going in the liver. “And you have a 50 percent chance of “Three-quarters of all lower limb a Westminster-based company, to develop a “docking station” and “leaflet tissue” – making with no more activities,” Vesely says. They feel otherwise normal and healthy, but a cure,” Christoffersen says. Many simply amputees are over 65 and diabetic,” says commercial product that should be available in it easier for surgeons to implant. When the The valve is still in development, and the patients with chronic Hepatitis C have a liver forgo treatment; of the 4 million Americans Jerome Rifkin, president of Louisville-based 2009. leaflets wear out, which inevitably happens, company expects to do human trials in 2009. that’s filled with the virus.” who have this disease, only 3 percent get company. Diabetes is characterized by poor Likewise, an Aurora company is working “you don’t have to dig everything out of the “Our timeline suggests that we can be selling

18 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 19 Otologics LLC is developing Carina, a surgically implanted hearing aid device that contains a microphone, digital- in Europe in two years or so, with the U.S. signal processor and rechargeable battery with a projected after that,” Vesely says. 20-year life. Courtesy Otologics LLC One of the most frightening prospects for active, involved baby boomers is Alzheimer’s disease, which today afflicts more than 5 million Americans and is predicted to affect 30 million or more by 2050. Aurogen Inc., a Fort Collins-based biopharmaceutical “There is a societal company, is working on innovative treatments for the devastating disease. side to Alzheimer’s The company’s technology comes out of the lab of Colorado State University biomedical Disease,” says professor Douglas Ishii, who along with other researchers considers Alzheimer’s “a diabetic Aurogen Chief state of the brain,” explains Aurogen Chief Executive Officer Robert Caspari. With both Executive Officer diabetes and Alzheimer’s certain hormones are Robert Caspari. extremely low. Aurogen’s core technology is insulin-like “Patients can’t growth factor, or IGF-1, a key protein in the growth of neuron connectors, which both wait. If you’ve got Alzheimer’s and many diabetic patients lack. Many people with diabetes develop peripheral something that neuropathy in which nerves in the extremities die. Alzheimer’s is marked by the death of looks promising, synapses, the connectors in the brain that transmit information. there’s an imperative Ishii has been working on the technology with animals since 1992, and Caspari joined to get it tested.” the company in 2007 to commercialize it. “I have joined because it’s more than time to take the work to the next level, to bring this through human trials and approved through the FDA,” Caspari says. and CEO of Boulder-based Otologics LLC. condition,” Bedoya says. “I think it’s exactly surgeon injects diluted local anesthetic and Because of Ishii’s years of animal testing Further, he says, of those who buy hearing what we need. We’ve seen other devices go in epinephrine under the patient’s skin. The and awarded patents, Caspari thinks Aurogen’s aids, only 80 to 85 percent actually use them, this direction – knee implants, defibrillators – all doctor then uses a canula to suction out    drug can get into Phase II trials more quickly and of those, just 75 percent say they are evolving so by looking at an individual you the fat. During what Sound Surgical calls than most new compounds. “We have a lot “modestly satisfied.“ can’t tell they have this apparatus.” “LipoSelection,” a plastic surgeon inserts a   of safety and dosing information, which you To help those who won’t wear hearing aids Despite its hefty price tag – about $20,000 – “VASER,” a rapidly vibrating metal probe don’t have with a lot of new drugs. I think we for aesthetic or poor sound quality reasons, the device is actually cost-effective, Bedoya that ruptures or liquefies the fatty layer,   know a lot about giving this drug to humans.” or can’t due to certain ear sensitivities, says, The Carina lasts about 20 years, and before suction removal. The company is seeking investors and Otologics is developing the Carina, a as the technology improves the price should “By doing that we significantly reduce corporate partners to get the drug to market. surgically implanted hearing aid device. The come down significantly, he says. the trauma of the aspiration phase,” says   Speed is important, Caspari says. device, which contains a microphone, digital- No matter how young one feels on the company President William Cimino. “The  “There is a societal side to this,” Caspari signal processor and a rechargeable battery, inside, age eventually bestows double chins, idea is if you can make it less traumatic, you says. “Patients can’t wait. If you’ve got isn’t noticeable and has better sound quality love handles and flabby thighs on even the will have a faster, less painful recovery.” something that looks promising, there’s an than conventional hearing aids. Hearing fittest baby boomer. Because it’s more effective, LipoSelection is imperative to get it tested.” aids on the ear or in the ear canal pick up Out of the 11 million cosmetic plastic also safer for older patients. But Cimino says But it’s not only life-threatening diseases background noise as well as feedback from surgery procedures performed in the U.S. in LipoSelection is safer all patients. “There’s that baby boomers face. Time and gravity take sound waves bouncing off the eardrum. The 2006, close to 5 million were performed on always potential for surgical problem,” he says.  their toll on even the most beautiful people, Carina stimulates the bones of the middle ear women and men aged 40 to 54, according to “You have to be safe at every age.” and Colorado companies are addressing rather than the eardrum, reducing extraneous the American Society for Aesthetic Plastic Other Colorado companies addressing  quality-of-life concerns as well. noise as well as distortions. Surgery. Patients 55 and older had 2.8 million the health concerns of aging baby boomers Nothing symbolizes senior citizenship Otologics is in the final stages of the FDA cosmetic procedures. include: Martek BioSciences Corp.,       more than hearing aids, yet hearing loss isn’t approval process and expects to conclude Louisville-based Sound Surgical Efficas Inc., Allos Therapeutics Inc.,    limited to great-grandparents; AARP reports clinical trials in the U.S. in 2008, and to be Technologies LLC developed and markets a Covidien, Array BioPharma, Accera  those between 45 and 64 have more hearing on the market in 2009. The Carina is already product that makes one of the most popular Inc., Arca Biopharma Inc., Able Planet loss than those older than 65. And only one approved and in use in Europe. procedures – liposuction – less invasive and Inc., iBalance Medical LLC, Sierra in five individuals who need hearing aids are “It will be convenient, not apparent, and traumatic while producing better results. Neuropharmaceuticals, Aqueous buying them, says José H. Bedoya, president not indicative of any handicap or age-related During traditional liposuction, a plastic Biomedical and Cochlear Americas.

20 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 21 COLORADO GRANTS Colorado Knows How to Grow the Bioscience Industry: nine new companies formed with $2 Million grant program

n 2006, the Colorado projects will lead to new thera- UNIVERSITY OF COLORADO BioScience Association peutics, diagnostics or devices Tad Koch, Ph.D. (CU Boulder) - New targeted drugs for the Dr. Leland Shapiro (CU Denver) - Infusion of alpha-1-anti- and the Colorado Office of to improve human or animal Gary Brodsky, Ph.D. (CU Denver) - In vivo analysis of a car- treatment of lung cancer trypsin (AAT) to suppress human immunodeficiency virus Economic Development health or agriculture. Projects diac and skeletal muscle stem cell activator type-1 (HIV) replication in patients and International Trade drafted included technology related to DISCOVERY: Enzymes overexpressed in certain cancer cells can Ilegislation to help develop life sciences, engineering, mate- DISCOVERY: Protoeolytic processing prelamin A peptide is asso- be used to convert nontoxic prodrugs into the more toxic active DISCOVERY: Alpha-1 Antitrypsin can inhibit viral replication in the commercial potential of rial sciences, computer sciences, ciated with defective muscle regeneration from stem cell pools drug with reduced systemic toxicity. cultured human cell lines (ex vivo). bioscience technologies under photonics and nanotechnology. investigation within Colorado’s The investment resulted in GRANT-FUNDED RESEARCH: Manufacture the drug agent and show GRANT-FUNDED RESEARCH: Manufacture the drug agent and show GRANT-FUNDED RESEARCH: Obtain the drug and show that it research institutions. Sponsored decreasing the time it takes to that it works in valid animal disease models. that it works in valid animal disease models of lung cancer. reduces viral load in HIV patients. by Rep. Jim Riesberg and Sen. assess technologies, a more Ron Tupa, House Bill 1360 accurate valuation of the PRODUCT POSSIBILITIES: Drug and stem cell therapy for muscle PRODUCT POSSIBILITIES: Novel drugs to treat lung cancer without PRODUCT POSSIBILITIES: Use an existing drug to reduce HIV provided $2 million in matching technology, better information and heart diseases such as heart attacks and muscular dystrophy. toxic side effects of standard chemotherapy agents. viral load in drug-resistant patients, providing an alternative to grants. to attract early stage investors to the side effects of current anti-HIV therapies. There are 250,000 cases of lung cancer annually in the In 2007, the program helped startups created to advance the IMPACT: There are 500 new cases of muscular distrophy per year IMPACT: fund 26 proof-of-concept re- technology, and earlier weeding in the U.S. Myocardial infarction is the leading cause of death in developed world. IMPACT: Each year in the U.S., 40,000 people are newly infected search projects in six Colorado out of less-than-promising the U.S., with an incidence of 800,000 new cases annually. with HIV. Some 2 million people suffer from AIDS. research institutions. The technologies. The program has been very Dr. Edward “Jack” Dempsey (CU Denver) - Moving bryosta- successful. Out of the 26 funded Karen Stevens, Ph.D. (CU Denver) - A new treatment for inef- tin-1 from the lab to the clinic for the treatment of pulmonary technologies, nine will be spun fectively treated schizophrenia patients: pre-clinical validation hypertension out into commercial entities dur- for centrally administered clozapine ing 2008. DISCOVERY: Loss of protein Kinase C epsilon in mice is associ- The following research proj- DISCOVERY: Recognition that delivery of psychotropic drugs ated with pulmonary vascular disease phenotypes. ects received funding as a result into the brain limits toxic side effects associated with systemic of HB1360. delivery. GRANT-FUNDED RESEARCH: Show that the drug works in valid animal disease models of pulmonary hypertension.

GRANT-FUNDED RESEARCH: Reformulate the current standard of care for schizophrenia for direct delivery into the brain and show PRODUCT POSSIBILITIES: A new drug for the treatment of pulmo- therapeutic concentrations. nary hypertension.

PRODUCT POSSIBILITIES: New drug formulations designed for IMPACT: It is estimated that tens of millions of people are diag- less toxic schizophrenia therapy. nosed with pulmonary hypertension each year.

IMPACT: Some 2.2 million people suffer from schizophrenia in the U.S.

22 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 23 Robert Hodges, Ph.D., Kay Holmes, Ph.D. (CU Denver) - Dr. Jeffrey Holt (CU Denver) - Biomarker enabled develop- Validation of SARS coronavirus antibody technology to ment of PARP inhibitors for cancer therapy influenza virus DISCOVERY: Faulty phosphorylation of BRCA-1 and BRCA-2 DISCOVERY: A protein structure in X-ray crystallgraphs is re- is correlated with susceptibility. Current standard of care is to quired for corona viruses (the SARS virus specifically) to enter measure mutations in the respective genes at key phosphoryla- and infect the host cells. tion sites. The new test will look directly at the BRCA protein in tumor tissue. GRANT-FUNDED RESEARCH: Show that a biochemical feature of SARS virus is also a feature in influenza; make a vaccine against GRANT-FUNDED RESEARCH: Show that the diagnostic test can the feature and show that mice can generate an immune response to predict whether mice with breast and ovarian cancers will benefit the feature and thus the virus. from treatment with PARP inhibitors.

PRODUCT POSSIBILITIES: A new rapid recombinant vaccine for PRODUCT POSSIBILITIES: A diagnostic test to choose patients for a influenza. new class of cancer drugs.

IMPACT: There were 100 million flu vaccine doses shipped in the IMPACT: Each year, 1.2 million cases of breast cancer and 50,000 Dr. Douglas Graham (CU Denver) - A novel biologically tar- David Ross, Ph.D. (CU Denver) - Hydroquinone ansamycin U.S. in 2006. cases of ovarian cancer are found worldwide. geted agent for the treatment of non-small cell lung cancer prodrugs as novel anticancer Hsp90 inhibitors

DISCOVERY: The extracellular, soluble domain of Mer receptor DISCOVERY: Observation of reduced toxicities of geldanamycin Christopher Bowman, Ph.D. (CU Boulder) - Redux-initiated tyrosine kinase reduces the proliferation properties of Gas-6y in derivatives when substitutions occur at specific “hot spots” on Michael Larson, Ph.D. (CU Colorado Springs) - A device for radical chain polymerization for the detection and amplifica- cancer cell lines. the molecular backbone of geldanamycin. laser fusion of septal tissue tion of biological recognition events

DISCOVERY: Lasers can denature proteins in tissue, resulting in GRANT-FUNDED RESEARCH: Manufacture the drug agent and show GRANT-FUNDED RESEARCH: Manufacture the drug agent and show DISCOVERY: Use of photopolymerization for the amplication a biological “glue” from a patient’s own tissue that can hold a that it works in valid animal disease models of lung cancer. that it works in valid animal disease models of cancer. and detection of molecular recognition events, in particular a wound together without staples or sutures. relatively small number of events, based on amplification of the PRODUCT POSSIBILITIES: A new biologic drug for the treatment of PRODUCT POSSIBILITIES: A new, nontoxic derivative of a new signal due to each molecular recognition event. GRANT-FUNDED RESEARCH: Build a prototype and look at fusion the most common type of cancer, non-small cell lung cancer. drug class being used to treat cancer. performance in cadaver and living animal tissue. GRANT-FUNDED RESEARCH: Use of radical chain polymerization IMPACT: There are 250,000 cases annually in the developed IMPACT: There is an incidence of more than 500,000 cases and a to develop a rapid, inexpensive and sensitive diagnostic for the PRODUCT POSSIBILITIES: Laser technology to create a device for world. prevalence of more than 2.5 million cases of the five target solid advanced detection of lung cancer biomarkers. The necessary re- welding nasal tissue after the repair of a deviated septum. tumors, those in the lung, colon, skin, kidney and pancreas. actions utilize inexpensive and stable non-biological compounds under mild conditions. IMPACT: Currently about 2.2 million people suffer from a deviated septum in the U.S. Stephen Hunsucker, Ph.D. (CU Denver) - Protein biomarkers PRODUCT POSSIBILITIES: New rapid, inexpensive point-of-care to differently diagnose follicular thyroid carcinoma and fol- diagnostic tools for lung cancer. licular thyroid adenoma Steve Anderson, Ph.D. (CU Denver) - Suppression of irradia- IMPACT: Lung cancer is the leading cause of cancer deaths tion-induced salivary gland dysfunction by IGF-1 worldwide. There is a dismal 15 percent five-year survival rate DISCOVERY: Certain protein patterns were evident in the blood due to asymptomatic conditions in the disease’s early stages. of patients with confirmed head and neck cancers, but absent in DISCOVERY: Akt activation (induced by insulin growth factor-1) patients with no cancer. protects salivary glands from apoptosis during irradiation.

GRANT-FUNDED RESEARCH: In a clinical trial, results show that GRANT-FUNDED RESEARCH: The project will help determine candidate blood markers are predictive of which patients have appropriate dosage, investigate alternative delivery methods, head and neck cancer and which patients do not as verified by determine long-term efficacy and explore other animal models in biopsy. order to take the product to market.

PRODUCT POSSIBILITIES: A diagnostic tool to reduce the need for PRODUCT POSSIBILITIES: Treating side effects of radiation therapy biopsies when diagnosing head and neck cancers. in head and neck cancer.

IMPACT: There are 40,000 new cases of head and neck cancers IMPACT: There are 40,000 new cases of head and neck cancers diagnosed each year in the U.S. diagnosed each year in the U.S.

24 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 25 COLORADO STATE UNIVERSITY

Eric Monnet, DVM, Ph.D., Christopher Orton, DVM, Ph.D., Susan James, Ph.D. - External device to control functional mitral valve regurgitation

DISCOVERY: Functional mitral valve regurgitation or leakage of blood within the heart, if diagnosed along with chronic heart failure, significantly worsens.

GRANT-FUNDED RESEARCH: The initial animal study will implant Christian Puttlitz, Ph.D. - Development of an instrumented an external epicardial device and the effect on the heart will be cervical distractor studied with an electrocardiogram. DISCOVERY: An improvement to the Caspar pin distractor, which PRODUCT POSSIBILITIES: A modular form of an epicardial device is commonly used in anterior cervical discectomy with fusion that can be built in the thoracic cavity will allow it to be im- surgery. planted using minimally invasive surgery. GRANT-FUNDED RESEARCH: Three clinical trials are being per- IMPACT: Chronic heart failure is the primary cause of death formed using a modified commercial cervical disc distractor and of humans in Western countries. It has been estimated that customized electronic collection system to collect displacement congestive heart failure afflicts nearly 4 million Americans, with and strain data. 500,000 new cases each year. PRODUCT POSSIBILITIES: A better Caspar pin distractor with an internalized strain gauge and linear variable displacement trans- Andrei Kutateladze, Ph.D. - Encoding and screening of solu- Randy Bartels, Ph.D. - Development of a novel nonlinear UNIVERSITY OF DENVER ducer incorporated into it, which will connect to conveniently tion phase combinatorial libraries for drug candidates microscope for infectious prion detection packaged hardware and software via minimal wiring. Rahmat A. Shoureshi, Ph.D., Corinne Lengsfeld, Ph.D., Ian Welch DISCOVERY: High throughput combinatorial chemistry has DISCOVERY: Development of a prototype scanning microscope - Smart shoe insole for elderly fall prevention IMPACT: This improved device has the potential to be more at- become a leading technique in drug discovery, and optimizing using an Er:fiber based laser system with a simple, robust and tractive to use in the operating theater than the original Caspar the processes for generating and screening millions of drug relatively inexpensive design. device and will improve the outcomes of patients with degenera- DISCOVERY: A novel smart shoe insole, using a thin layer of em- candidates has become critical. tive disc disease. bedded electronics and an artificial intelligence system, which GRANT-FUNDED RESEARCH: Simulations of this process are being helps the elderly know their stability condition. conducted and demonstration experiments are being performed. GRANT-FUNDED RESEARCH: Researchers on this project have developed and demonstrated a new method of screening of solu- Bill Dernell, DVM - Evaluation of lymphatic drainage and GRANT-FUNDED RESEARCH: Smart shoe prototypes have been used PRODUCT POSSIBILITIES: This technique will enable a new class uptake following intra-cavitary chemotherapy administration on healthy young adults to monitor their balance and determine tion phase combinatorial libraries (SPCL). of nanoscale imaging. It may enable low-cost, rapid screen- for mammary carcinoma key factors contributing to the maintenance of balance. Develop- ing for bovine spongiform encephalopathy (mad cow disease), ment of alarms based on a real-time data collection and artificial PRODUCT POSSIBILITIES: SPCL technology creates a library ensuring the safety of the food supply and the viability of beef DISCOVERY: Sustained release of anticancer chemotherapy agents neuron-fuzzy networks will also aid in the efficacy and effective- of drug candidates, each of which is uniquely identified by a exports. from biodegradable polymer systems placed into a wound bed ness of these insoles. chemical tag. following conservative surgical removal of breast tumors. IMPACT: This imaging modality may have novel applications in PRODUCT POSSIBILITIES: The device could be used in a wide IMPACT: This technique has significant advantages over conven- cancer treatment, cancer biology, histopathology and proteomics. The animal study evaluates the GRANT-FUNDED RESEARCH: variety of applications including fitting of prosthetic legs, diag- tional screening techniques, with no known deficiencies. amount of chemotherapy that reaches the local lymph nodes nosis of foot ailments, monitoring of joint replacements, fatigue through this method. analysis and drug interactions, design of personalized athletic shoes, and as an insole for type-II diabetic patients with loss of PRODUCT POSSIBILITIES: Local polymer delivery of chemo- sensation in extremities to prevent ulceration and neuropathy. therapy for breast cancer, which may also be adapted to other cancers and non-cancer diseases that preferentially spread to the IMPACT: Reducing the number of falls experienced by the elderly lymphatics. will not only improve their quality of life, it will reduce medical

IMPACT: Despite the increase in early detection, advanced breast bills and hospital stays. cancer still results in high mortality, with a 26 percent 5-year survival rate for breast cancer with distant metastases.

26 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 27 NATIONAL JEWISH MEDICAL AND UNIVERSITY OF NORTHERN COLORADO RESEARCH CENTER Rebecca O’Brien, Ph.D. - Use of soluble gamma/delta T cell receptors in reducing inflammatory damage Stephen Mackessy, Ph.D. - New compounds from snake ven- Willi K. Born, Ph.D. - Inhaled anti-T-cell-receptor antibodies for oms: A proteomics approach toward the development of drugs the treatment of airway hyper-responsiveness and inflammation DISCOVERY: Gamma/delta T cells have been shown to be impor- from toxins tant in regulating inflammatory responses. This project hypoth- esizes that injecting a soluble T-cell receptor (TCR) into a mouse DISCOVERY: Injecting anti-T cell receptor antibodies in mice Dr. Erwin W. Gelfand - Heat shock DISCOVERY: Snake venom is comprised of protein compounds can reduce inflammatory damage caused by a bacterial infection results in the specific and systemic depletion of the subsets of T proteins modify lung allergic inflammatory responses which may be useful to treat human diseases and disorders. by binding to and soaking up all the molecules that would nor- cells that can be the driving force in the development of airway Very preliminary results suggest that a small protein from the hyperresponsiveness and airway inflammation. Born’s team DISCOVERY: Allergic diseases including asthma are believed to be mally activate inflammation-promoting gamma/delta T cells. venom of the Puerto Rican racer may inhibit cell proliferation in has found that these antibodies also function when they are the result of an imbalanced immune response, skewed away from cultured breast cancer cells. inhaled. what is known as Th1 in favor of a Th2 response. In an animal GRANT-FUNDED RESEARCH: O’Brien’s team intends to perform experiments to show whether a soluble gamma/delta TCR can be model of allergen-induced asthma, administration of one such GRANT-FUNDED RESEARCH: The team is characterizing these used to block specific gamma/delta T cell responses in a disease GRANT-FUNDED RESEARCH: Testing will show if the antibodies heat shock protein provided significant protection against the molecules and purifying additional compounds for ongoing model (listeria infection) in mice, and if so, whether blocking have similar effects and efficacy in allergic nonhuman primates, development of allergen-induced airway hyperresponsiveness evaluation of the use of venom toxins as drugs. and therefore will move this potential therapy closer to clinical and airway inflammation. this response reduces inflammatory damage.

trials in humans. PRODUCT POSSIBILITIES: A new drug to treat breast cancer. GRANT-FUNDED RESEARCH: This study proposes to show that PRODUCT POSSIBILITIES: Soluble gamma/delta TCRs may be administration of one hsp can reduce allergic reactions in an ani- useful as drugs that can alter the inflammatory response and PRODUCT POSSIBILITIES: Treatment of asthma; only T cells in the IMPACT: The chance of developing invasive breast cancer at mal model of allergic asthma by shifting the immune response perhaps prevent tissue damage. In this way, they could be helpful lungs and airways are affected, leaving an organism’s disease- some time in a woman’s life is about one in 12. It is estimated in treating a wide variety of diseases, including rheumatoid ar- fighting ability intact. away from Th2 toward Th1. that in 2008, about 182,000 new cases of invasive breast cancer thritis, inflammatory bowel disease, multiple sclerosis, systemic will be diagnosed among women in the U.S. lupus, psoriasis, COPD, sepsis, and heart disease. IMPACT: The prevalence of asthma in industrialized nations has PRODUCT POSSIBILITIES: Treatment of asthma. been increasing over the last 30 years with about 10 percent of the population affected now. IMPACT: A new therapeutic approach to asthma treatment with IMPACT: Control of inflammation is becoming central to the the potential to modify existing disease and prevent progression. treatment of a wide variety of diseases and current pharmaco- logic treatments are not always effective.

Brian J. Day, Ph.D. - Development of novel therapies to treat chronic lung disease Dr. Jerry A. Nick - A method for the prevention and treatment of Pseudomonas biofilm infections BONFILS BLOOD CENTER FOUNDATION DISCOVERY: A number of lung diseases are associated with abnormally low levels of glutathione (GSH). The team hypothe- DISCOVERY: Infections by the bacteria pseudomonas aeruginosa Dr. Daniel Ambruso - Transfusion related acute lung injury sizes that therapeutic manipulation of the lung’s own GSH levels (PA) are serious and often life-threatening events, particularly (TRALI) identification kit would provide a novel therapeutic approach. when the bacteria forms a biofilm. The team has discovered a class of non-toxic compounds that appears to disrupt and even DISCOVERY: An increase in blood transfusions has also led to an GRANT-FUNDED RESEARCH: Two lead compounds will be tested in prevent the formation of pseudomonas biofilms in the laboratory. increase in adverse transfusion events, some of them fatal. an acute lung inflammatory animal model as a pre-clinical proof of principle. GRANT-FUNDED RESEARCH: The team will first custom design and GRANT-FUNDED RESEARCH: To validate different platforms using synthesize a unique compound with enhanced bioavailability. standard blood components and samples from patients sustaining

PRODUCT POSSIBILITIES: Treatment of idiopathic pulmonary They will test the candidate products in the context of bacterial transfusion-related acute lung injury (TRALI). fibrosis, acute respiratory distress syndrome, cystic fibrosis, and keratitis, a biofilm infection caused by PA on the eyes of contact lung transplantation. lens wearers. The third phase of this project will be to utilize PRODUCT POSSIBILITIES: Development of a test kit that will be two animal models to provide pre-clinical data on the use of this used by physicians to determine if their patients are suffering product. from TRALI. IMPACT: A novel treatment for a wide variety of lung diseases using an existing protective mechanism in humans. PRODUCT POSSIBILITIES: A treatment for PA infections. IMPACT: TRALI is the No. 1 cause of death related to blood transfusions. IMPACT: PA infections are serious and often life-threatening conditions. In clinical settings, these infections are particularly difficult (or impossible) to treat.

28 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 29 BIOSCIENCE + DIAGNOSTICS Diagnosis as cure: Methods for finding

The AlphaSniffer 207B1 can be used to detect disease often provide very small particles including microRNAs, some of which have been linked to cancer and heart disease. BiOptix President and CEO Misha Plam treatment as well (pictured at right) says the technology could be used to quickly diagnose heart attacks in hospital emergency rooms. COURTESY BIOPTIX INC.

BY CARON SCHWARTZ ELLIS

any Colorado companies are developing novel diagnostic and drug delivery tools – using M technologies borrowed from the non-medical community – to determine the causes of and deliver treatments for ailments ranging from heart disease to cancer. One such company, mBio Diagnostics, is using laser technology developed by parent company Precision Photonics to create low- The new company is developing a chip SPR-CPI, developed by Nobel laureate Jan method requires several hours of prep under a half an hour time frame with cost, easy-to-use diagnostic chips. “We are measurement folks,” ex- that can detect biological markers in a blood Hall of NIST and the University of Colorado. work and is prone to errors.” fewer errors.” “We are measurement folks,” explains sample when a laser shines on it. The technique combines SPR – an optical The company first thought to use Mass spectrometry is a fairly plains Chris Myatt, co-founder Chris Myatt, co-founder and CEO of both “We stain (the samples) with fluorescent method for measuring the refractive index SPR-CPI to solve the military’s need for common analytical technique to Boulder-based companies. “We were looking dyes,” Myatt says, “and with our overall of very thin layers of material adsorbed on a portable, low-power device to detect determine a physical sample’s and CEO of mBio Diagnostics. for opportunities for our technology, and saw detection scheme you can pick out markers metal – and interferometry, or superimposing chemical and biological warfare agents. composition by measuring the mass- a fair amount of overlap (between our lasers) that say HIV or Hepatitis C.” two or more light waves to detect differences But with the March 2008 addition of to-charge ratio of its ions. Boulder and “(We) saw a fair amount of and what you would need for a very sensitive Myatt estimates it will take two or three in their polarity. former Myogen CEO William Freytag Steamboat Springs-based Biodesix Inc. detector of proteins or viruses.” years to get through FDA testing and bring Hall’s innovation is single-beam as chairman, the company is now is using the proteins found using this overlap (between our lasers) the device to market. Precision Photonics interferometry, in which the different targeting the medical diagnostic market. technique for molecular diagnostics and supplies the personnel and office space, polarizations of light are able to travel Its technology can be used to measure personalized medicine. and what you would need for while grants from the National Institutes of together in one beam. microRNAs, or single-stranded RNA There’s a big difference between Health and the National Institute of Standards “Because of the physics of single beam molecules. Certain microRNAs have tests based on genes and those based a very sensitive detector of and Technology (NIST) worth $5 million interferometry,” said BiOptix President and been linked to cancer and heart disease. on protein analysis, says Biodesix CEO proteins or viruses.” are funding mBio Diagnostics’ product CEO Misha Plam, “it’s a much simpler, BiOptix’s technology, Plam says, could David Brunel. For women with a family development. smaller, less expensive, more user-friendly be used to quickly diagnose heart history of breast cancer, a genetic test BiOptix LLC is also using photonics instrument.” attacks in the emergency room. can determine if they have an altered technology originally intended for a non- Another benefit, he adds, is BiOptix’s “It takes days to measure one BRCA1 or BRCA2 gene, but it doesn’t medical application. It employs a technology technology doesn’t require samples dosed microRNA,” Plam says, “And present reveal the presence of the disease. known as “surface plasmon resonance- with fluorescent dye. “We don’t attach techniques are prone to errors…we can “In a protein assay,” Brunel says, enhanced common path interferometry” or anything,” Plam says. “The fluorescent hope we can measure microRNAs in “we might look to see if the disease has

30 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 31 started by looking for particular proteins to NSCLC is treated with surgery. But if the are involved in the growth of the cancer. BIOSCIENCE + INCENTIVES show if cancer does exist.” cancer has spread, patients get chemotherapy. VeriStrat, in Phase III clinical trials Biodesix’s first product, VeriStrat, is a Most patients will eventually show some expected to finish in 2009, can help doctors blood test that provides additional information resistance to chemotherapy, and the disease determine the most effective treatment. It to oncologists treating non-small cell lung will progress. New “targeted therapies” are tests patients to show whether a targeted carcinoma (NSCLC). In its early stages, available, which attack specific proteins that therapy like Tarceva will work for them, or whether another round of a different kind of chemotherapy would be more appropriate. “The idea is to get the right treatment to the right patient at the right time,” Brunel says. Colorado Invests Centennial-based Cell>Point is developing molecular imaging agents for the diagnosis and treatment of cancer and cardiovascular diseases. The agents are better diagnostic in the Biosciences tools than CT or MRI scans because they are disease-specific, says President F. David Rollo. “We give a radioactive injection that BY LEAH KIENTZ looks for the cells that have specific characteristics,” Rollo says. “The receptor on breast cancer would be different than that on bioscience THE BIOSCIENCE DISCOVERY EVALUATION THE JOB CREATION PERFORMANCE INCENTIVE FUND lung cancer.” cluster with GRANT PROGRAM Companies that maintain new positions with salaries at A primary advantage of the company’s world-renowned The Bioscience Discovery Evaluation Grant Program least 110 percent above the average in their counties for one Ethylenedicysteine (EC) technology -- Tc- resources and (BDEG), originally funded for $4.5 million over the past year will be awarded a performance-based incentive. Three labeled glucosamine (99mTc-EC-G) -- is the talentsA sits at the base of two years, will receive another $26.5 million over the million dollars will be distributed annually by the Economic specific diagnosis. Today, if a person goes to the Rocky Mountains. next five years from the state legislature to help grow Development Commission (EDC) with administrative the doctor with shortness of breath, bloody Colorado’s growing the bioscience industry in Colorado. The funds will be support from the Office of Economic Development and In- sputum and chest pain, he might get a CT. bioscience industry disbursed through the Colorado Office of Economic ternational Trade. The goal of this program is to foster new If it reveals a potentially cancerous lesion, proves that this skier’s Development and International Trade (OED). business development, business expansion and relocations he would get surgery. Once under the knife paradise has not only The BDEG program provides 30 percent of the funds that generate new jobs within the state. the surgeon might discover the lesion is beautiful scenery but for “proof of concept” matching grants through the Companies located in rural areas must hire at least five tuberculosis or an infection that could have also internationally OED to Colorado technology transfer offices to acceler- new full-time employees in six months and companies in been treated with an antibiotic. “It would help competitive research ate commercialization of bioscience technologies up to urban areas must hire 10 new full-time employees in six avoid unnecessary, inappropriate procedures,” facilities, investors and $150,000 per research project. Evidence of a dedicated, months. Businesses with multiple locations in Colorado Rollo says, “You could have treated it right if bioscience firms. matching source of monies that is equal to the amount may combine locations to meet the minimum require- you knew what it was.” While many states are applied for under the program is required and cannot be ments. Contact OED at www.AdvanceColorado.com Another advantage is that the technology itching to grow their own used to supplement the funding of the research scope of 99m finds out if cancer has spread; Tc-EC-G bioscience clusters, the the project. ENHANCED INCENTIVE FUND will reveal all instances of cancer throughout Colorado state govern- Another 30 percent of the funds are provided as The Enhanced Incentive Program provides additional the body as well as the primary lesion. “Most ment has been nurturing matching grants to early stage Colorado-based biosci- performance-based incentives to companies that qualify metastases are so small you don’t see them this sector for 20 years. As ence companies that have licensed a technology from a under the Colorado Job Creation Performance Incentive on the CT or MRI. If you knew it had already a result, there are a variety state research institution. These state matching funds Fund and have created jobs with wages that exceed the spread you would use a different procedure,” of state-led business will be given to companies that have received less than average wage rate in their county by more than 120 per- Rollo says. incentives and invest- $5 million dollars from grants and third-party investors cent. The program is designed to support and promote For cancer that has spread, Cell>Point’s ment funds for bioscience and that employ fewer than 20. The grants shall be for highly desirable, high-impact job creation opportunities. In-Situ Hydrogel is being developed as a firms. These incentives no more than $250,000 over the lifetime of the company. The EDC allocates the funds available until available site-specific regional chemotherapy and help Colorado’s research Evidence of a dedicated, matching source of monies that funds in a given year have been expended.Contact OED radiotherapy delivery system. Intravenous institutions spin out a is equal to the amount applied for under the program is at www.AdvanceColorado.com chemotherapy not only kills cancer cells, handful of new companies required. it affects healthy organs such as the heart, a year and bring more Lastly, up to 40 percent is dedicated to support BIOTECHNOLOGY R&D SALES AND USE TAX REFUND kidneys and brain. Cell>Point’s therapy is business to the Rocky partnership efforts between the bioscience industry and Colorado’s biotechnology industry has the ability to given as one injection and goes only to the Mountain region. research institutions to build infrastructure that supports recover the sales and use taxes paid in the preceding disease, “like a guided missile,” Rollo says. Here is a look at the the commercialization of therapeutic and diagnostic year on equipment and supplies purchased to conduct “So I can tell you ‘you have lung cancer and programs: products, devices or instruments to improve human biotechnology research and development. The biotech it’s spread.’ This is a terrible thing. But the health, agriculture and biofuels. company may seek a refund every year for all Colo- good news is that the agent that goes to the For more information on the Bioscience Discovery rado sales and use taxes paid on purchases of tangible cancer can also be used for therapy, so the Evaluation Grant Program or to apply, please visit www. personal property used directly in research and develop- therapy only kills the cancer.” AdvanceColorado.com. ment of biotechnology. Qualified applicants must sub- Other Colorado companies developing mit a refund claim by between January 1 and April 1 to diagnostic tools include: MicroPhage Inc.; the Colorado Department of Revenue. The refund helps SomaLogic Inc.; Sciona Inc. and Source promote the biotechnology industry in the state, aiding MDx Inc.

32 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 33 both start-up and established companies. provide loans and equity to Colorado business- The EDC approves loans and grants from the BIOSCIENCE + GLOBAL HEALTH To find out more information or to submit a es. Investments range from $100,000 to $3.3 economic development fund to help existing refund claim, contact the Colorado Department million. businesses expand and new companies locate of Revenue or visit www.revenue.state.co.us. To receive funding you must contact the in Colorado. It also implements marketing CAPCOs directly. To view a list of CAPCOs programs to support ongoing business activi- MANUFACTURING EQUIPMENT EXEMPTION FROM please visit www.state.co.us/oed/business- ties. All policy and funding decisions are made Health care COLORADO SALES AND USE TAX finance/ capco-list.cfm. by the nine commission members. The com- The purchase of machinery or machine mission is also responsible for policy decisions tools and parts are exempt from state sales and VENTURE CAPITAL AUTHORITY concerning the state enterprise zone program. without borders: use tax when the machinery will be used in The Colorado General Assembly in 2004 For more information on the EDC please manufacturing. The machinery must be used passed legislation that established the Colo- visit www.AdvanceColorado.com to manufacture tangible personal property for rado Venture Capital Authority (VCA), and in Colorado companies share sale or profit in Colorado. The tax exemp- 2005 High County Venture was selected as the ENTERPRISE ZONE tion includes tangible personal property that fund manager to establish the first fund. Colo- Colorado’s enterprise zone program pro- will be used for one year or more and limits rado Fund 1 will make seed- and early-stage vides tax incentives to encourage businesses to medical treatments qualifying purchases of used equipment to a capital investments in businesses. The VCA locate and expand in economically distressed maximum of $150,000 annually. anticipates the establishment of a second fund areas. Criteria for the establishment of zones For more information, contact the Colorado of approximately $25 million in 2010. include higher-than-average unemployment worldwide Department of Revenue at www.revenue.state. High Country Venture is independently rates, low per capita incomes, and/or a popula- co.us. operated and generally makes independent tion base of less than 80,000. There are 18 funding decisions. State approval is limited enterprise zones and subzones in Colorado. A child with diarrhea receives an oral rehydra- CERTIFIED CAPITAL COMPANIES (CAPCOS) to ensuring that businesses receiving funding Businesses making qualifying investments n today’s global economy, not only are it for 5 cents, you are probably going to do it,” The Certified Capital Companies Program meet minimum specified requirements. Invest- and creating jobs in these zones are entitled goods and services readily shared across says company founder and President Kathy tion solution at Instituto Especializado de Salud was created by the Colorado legislature with the ments range from $250,000 to $3.375 million. to various incentives, including ten different borders, but diseases are as well. The good Callender. del Niño (Children’s Hospital) in Lima, Peru. goal of making venture capital funds available For more information or to submit a funding enterprise zone tax credits. news is that treatments for those diseases The Golden-based company has developed Ventria Biosciences manufactures nutritional to new or expanding Colorado small business- request, please visit www.Coloradofund1.com. To view the enterprise zones or for more in- Iare also being distributed globally. Colorado a family of patented needle-free injection tech- drinks containing lactoferrin and lysozyme, pro- es. The CAPCO Program is expected to create formation on tax incentives, please visit www. companies are working on providing remedies nologies that deliver liquid medicines through teins found in human breast milk that rehydrate and help children heal quickly from diarrheal new employment opportunities within the state ECONOMIC DEVELOPMENT COMMISSION AdvanceColorado.com. to developing countries whose economies are the skin. The sterile, plastic tool is designed and to stimulate economic growth. Colorado The EDC was created by the legislature to further along than their health-care facilities. for a single use, and the injector, made of disease. COURTESY VENTRIA BIOSCIENCES has six independently-operated CAPCOs that promote economic development in Colorado. JOB TRAINING GRANT FUNDS Ventria Bioscience is developing treat- high-grade plastic and stainless steel, can be The Colorado First and Existing Indus- ments for diarrhea. The ailment is rarely life used thousands of times. In 2004, PharmaJet break the cold chain, the company is develop- try grants are jointly administered by the threatening in the U.S., but kills about 4,500 received its first 510(k) marketing clearance ing a dry, inhalable vaccine. There are other OED and the Colorado Community College children a day in regions that lack clean water from the FDA, with designation as a class II benefits, says President Brian Quinn. Since no System. Colorado First grants are provided to and basic sanitation facilities. The company medical device. needles are required, little training is needed to companies relocating to Colorado or existing manufactures nutritional drinks containing According to Callender, PharmaJet pushes administer the vaccine, and there’s no danger companies undertaking a major expansion. lactoferrin and lysozyme, proteins found in drugs into the body as if through a “garden of spreading disease through accidental needle The Existing Industry grants are designed for human breast milk that rehydrate children and spray,” hitting more cells than a needle. She sticks. Colorado companies that are implementing help them heal. thinks this makes the delivery system more Aktiv-Dry did not reinvent the vaccine. $PMPSBEP new technology in order to remain competitive *OWFTUJOHJO#JPTDJFODF%FWFMPQNFOU Ventria, which relocated to Fort Collins effective. Studies have shown that vaccines Rather, it uses a well-known measles vaccine and retain local jobs. from Sacramento, Calif. in 2008, creates these introduced this way induce higher antibody manufactured by the Serum Institute of India, CJPTDJFODFDPNQBOJFTDBMM$PMPSBEPIPNF Both grants assist with the cost of employee proteins from a special variety of rice with production. which makes two-thirds of all childhood vac- training. The grant-funded training must be no known allergens. This rice is processed “In dogs we used half the amount of vaccines used around the world. FNQMPZJOH JOUIFTUBUF for permanent full-time positions that require by Ventria’s proprietary technology platform, cine and got the same amount of antibody “We are taking that vaccine and using our substantive and company-specific training. ExpressTec. production as the full amount,” Callender says. super-critical carbon dioxi de technology to Training must occur within the fiscal year that Ventria doesn’t only manufacture the end Because of this, vaccine expenditures could be make the vaccine as very, very fine particles funds are awarded, and the company must pay product, but has created a closed production reduced, better utilizing vaccine resources. – about 3 microns – that get down deep into *O UIF4UBUFPG$PMPSBEPQBTTFEMPOHUFSNMFHJTMBUJPO a minimum of 40 percent of the total cost of system. It owns the U.S. and South American The tenth-of-a-second procedure is also less alveoli of the lungs,” Quinn says. “Cigarette EFTJHOFEUPQSPNPUFUIFHSPXUIBOETVTUBJOBCJMJUZPGUIF#JPTDJFODF training. The grant applications are reviewed farms where the rice is grown as well as the painful than a needle, Callender says. “Most smoke particles are larger than that.” Accord- TFDUPS1SPHSBNTXJMMQSPWJEFNBUDIJOHQSPPGPGDPODFQU on a rolling basis throughout each fiscal year, Kansas production facility. people say they feel much less discomfort, or ing to Quinn, the vaccine will go into clinical and the grants generally fund up to $800 per The product, which Ventria hasn’t branded nothing.” trials in 2010. HSBOUTUP$PMPSBEPTSFTFBSDIJOTUJUVUJPOT employee. yet, will be released in the U.S. in late 2008 or In 2008, the system will enter human clini- Aktiv-Dry also developed devices to deliver BOEGVOEJOHUPFBSMZTUBHFDPNQBOJFT To apply for the grants or for more informa- early 2009. Ventria will then market it globally. cal trials. In Brazil, the company will test all the vaccine. Its PuffHaler is basically a balloon $POUBDUVTUPTFFIPXXFDBO tion, please visit www.AdvanceColorado.com “In developing countries like China and In- the common childhood vaccines along with that when squeezed releases the vaccine. Kids JOWFTUJOZPVSDPNQBOZ dia, we’ll work with the governments (to bring yellow fever, and in Hong Kong, it will test just breathe it in. LOCAL INCENTIVES it to market),” says Chief Executive Officer HPV (human papillomavirus). “It’s very simple,” Quinn says, “and key 0GmDFPG&DPOPNJD Your local community may also provide Scott Deeter. “In emerging countries it will Aktiv-Dry LLC is addressing measles, an thing is that it is human-powered. You don’t business development incentives. For addition- (be funded) through foundation support. In illness that has been virtually eradicated in need electricity or power or anything, which is %FWFMPQNFOUBOE al information, contact your local economic those markets we don’t seek a profit; it’s more the United States, but that the World Health very important in developing economies.” *OUFSOBUJPOBM development organization. A list can be found a humanitarian benefit.” Organization estimates kills more than 2,000 The company’s research is being paid for at www.AdvanceColorado.com. PharmaJet Inc. is fighting a big problem children daily in poor nations. Because these by a five-year $19.5 million grant from the 5SBEF Go to www.coloradoprospects.com to find in the developing world – needle reuse. children live in parts of the world with no Foundation for the National Institutes of more information about Colorado’s business “If you only make 30 cents a day, and you electricity, liquid vaccines are out of the ques- Health. The grant is part of the $436 million #SPBEXBZt4VJUFt%FOWFS $0ttXXX"EWBODF$PMPSBEPDPN incentives. have the opportunity to grab a needle and sell tion because they require refrigeration. To Grand Challenges in Global Health initiative

34 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 35 Rockefeller Foundation and the government of the Republic of Korea. In 2007 the company Colorado Scien ce and Technology park at BIOSCIENCE + REAL ESTATE also received a two-year, $600,000 grant from the National Institutes of Health to develop a Fitzsimons Boos ted by Private Investment and Public Science bird flu vaccine, a disease that since 2003 has Aktiv-Dry LLC creates both dry, inhalable vaccines infected 355 individuals, 206 fatally. Research and devices to deliver them. When squeezed the is being done in collaboration with the Univer- BY CARON SCHWARTZ ELLIS proximity to the Anschutz Medical Campus ideas or discuss plans. Park tenants and companies, said Vicki Jenings, director PuffHaler releases the vaccine so kids simply breath sity of Wisconsin. and the Children’s Hospital,” Chrisman said. visitors alike will be encouraged to utilize of business relations for the Fitzsimons it in. “It’s very simple, and key thing is they are Roche Colorado, the Boulder-based facil- ith more than 6 million square “Our plan is to construct lab and office space these parks.” Redevelopment Authority. human-powered. You don’t need electricity or power ity of Basel, Switzerland pharmaceutical giant feet of scientific possibilities, to anticipate companies’ needs, because we In addition, park buildings will be “To date, we have graduated about 10 or anything, which is very important in developing F. Hoffman-La Roche Ltd., manufactures Colorado’s largest biotech and understand the importance of having space constructed in line with Forest City’s core companies that have gone on to larger economies,” says President Brian Quinn. Fuzeon, an anti-HIV drug that blocks the vi- medical community is rising like readily available for bioscience companies as value of sustainability, including xeriscaping, facilities. We look forward to growing aW phoenix from the ashes of a former army they expand or relocate.” energy efficient building materials and other companies in buildings right here on the COURTESY AKTIV-DRY LLC rus’ entry into healthy T cells. Although readily available in the U.S., the cost of the drug medical center. According to Forest City’s 2008 urban components that meet LEED® building site,” Jenings said. launched by the Bill and Melinda Gates Foun- is out of reach for many in Africa and other Forest City Science + Technology design guidelines for the park, “the standards. What will become the state’s largest dation in 2003. developing regions. According to the Joint Group, in partnership with the Fitzsimons buildings, open space and streetscapes will Sustainability is ingrained in the culture bioscience cluster is 15 minutes from Fort Collins-based Inviragen Inc. is fight- United Nations Program on HIV/AIDS, in Redevelopment Authority, is developing be seamlessly designed and interconnected of Forest City Enterprises and is one of the downtown Denver and Denver International ing to prevent the 15 million deaths worldwide 2007 in Africa alone there were 32.8 million the Colorado Science + Technology Park with Fitzsimons Commons, The University of company’s eight core values. Airport, has close interstate access and will each year from infectious diseases prevalent in people living with HIV, 2.5 million new HIV at Fitzsimons. The park is part of the Colorado Medical Campus and the adjacent “The built environment has profound have future light rail access. The park is also developing nations. The company is creating infections and 2 million deaths from AIDS. 578-acre former Fitzsimons Army Medical neighborhoods and regional park system. impact on our natural environment, economy, adjacent to Forest City’s redevelopment of recombinant viral vaccines to protect against To make Fuzeon affordable, “We have a Center in Aurora. Next-door neighbors “Carefully considered design of these health and productivity. The Urban Design the former Stapleton International Airport threats such as dengue fever, avian flu and policy to sell it at no profit to 63 countries include the University of Colorado Denver elements will enrich the experience for Guidelines call for all real estate development as a master planned community of homes, plague/smallpox. and (throughout) sub-Saharan Africa,” says Anschutz Medical Campus and the the park tenants and visitors alike and will to address broad sustainable design and commercial space, shops, schools and parks. The company’s lead product is DENVax, a Maria Vigneau, Roche’s director of access and Children’s Hospital. encourage them to stay within the park environs construction principles and practices,” The Colorado Science + Technology Park’s vaccine for dengue fever. Dengue viruses are sustainability. Roche also doesn’t file patents The synergy created by the research beyond the hours of the normal workday,” the according to the guidelines. $2 billion redevelopment is a 30-year project endemic throughout the world’s subtropical on antiretroviral drugs in certain developing and development conducted by private guidelines state. “Public open spaces will foster There are two bioscience buildings expected to add at least 10,000 high-paying and tropical regions. According to the Pediat- areas. bioscience companies and the research and a collegial atmosphere and provide workers currently at Fitzsimons: Bioscience Park jobs to the Denver metropolitan area. ric Dengue Vaccine Initiative (PDVI), every “We’ve removed both patents and profits from clinical endeavors at these two medical with a place to meet and converse. Center and Bioscience East. These buildings For additional information, please call 9281 Bioscience Colo. Ad 2/6/06 11:09 AM Page 1 year the mosquito-borne illness threatens more these medicines where they are needed most,” facilities is the spark that makes this vision “Outdoor café settings will inspire are designed to house early-stage life-science Forest City Enterprises at 720.941.7100 or than 3.5 billion people and infects about 100 Vigneau says. come to life. This bench-to-bedside concept informal gatherings where workers can share companies and are currently home to 30 visit www.FitzScience.com. million. DENVax is being developed through The company also gives employees the has proven successful around the world. an exclusive licensing agreement with the opportunity to take three- to 18-month paid Forest City Science + Technology Group Centers for Disease Control and Prevention’s sabbaticals to work on health-care projects. understands how to build bioscience Fort Collins lab. The vaccine will enter Phase I “Our focus is on making a long-term sustain- labs and offices and has been developing clinical trials in 2008. able difference and sharing knowledge and science and technology parks for more If everything goes well, President and CEO expertise where it is needed most,” Vigneau than 20 years. Achievements include Dan Stinchcomb says, Inviragen will launch says. University Park at MIT, Illinois Science + the product in 2012. Other Colorado companies addressing Technology Park, Translational Research The research is being funded by the PDVI, global health care needs include: Gilead Sci- Lab at the University of Pennsylvania and the Bill and Melinda Gates Foundation, the ences Inc. and Oberon FMR Inc. the Science + Technology Park at Johns Hopkins. “This large parcel of land in Aurora provides an opportunity to expand upon Realize the Possibilities the existing Colorado life science industry and grow it into an even more significant industry for the state,” said Jim Chrisman, Forest City’s senior vice president of Aurora isis homehome toto Fitzsimons,Fitzsimons, one one ofof thethe largestlargest biosciencebioscience redevelopmentsredevelopments inin thethe development. United States. The 578 acre project is undergoing a $4.3 billion transformation that The Colorado Science + Technology will result in over 15 million square feet of space dedicated to patient and clinical Park’s next 65,000 square foot multi- care, education, research and development. tenant office and lab building is scheduled to begin construction in 2008. Other The Aurora Economic Development Council is the economic development agency developments planned for this year include responsible for packaging incentives, off-site infrastructure and transportation a 40,000 square-foot, privately owned lab issuesissues thatthat areare relatedrelated toto Fitzsimons.Fitzsimons. Contact Contact usus andand realizerealize thethe possibilities.possibilities. building; a 175,000 square-foot office building; a credit union facility and a 200- room hotel and conference center. The park’s total capacity is more than 6 million square feet. “The buildings at the Colorado Science+ Technology Park at Fitzsimons will be designed to be flexible in order to meet the needs of a life science community that values 562 Sable Boulevard • Suite 240 • Aurora, Colorado 80011 • 303.340.2101 • www.auroraedc.com

36 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 37 Advanced Headache Intervention Inc. Aerophase Inc. Agilent Technologies Centennial Longmont Fort Collins www.PainZap.com www.aerophase.com www.agilent.com Develops a special purpose electrosurgery Researches and develops technologies Provides core electronic and bio- generator and probe for use in the therapeutic that improve health care including a analytical measurement tools to advance treatment of migraine headaches. meter dose inhaler and an improved life science research. DIRECTORY aerosol therapy for lung cancer. Advanced MicroLabs LLC AirLift Unlimited Inc. Fort Collins Aesthetic Technologies Evergreen www.advancedmicrolabs.com Golden www.airlift.com Researches and develops chemical www.atimed.com Develops and manufactures soft-sided Accelr8 Technology Corporation analytical instruments in ‘lab-on-a-chip’ Manufactures and sells Parisian Peel® oxygen carriers. INDEX Denver format. brand microdermabrasion systems and www.accelr8.com 38 Medical Device and Related Companies accessories along with skin care products Allison Medical Inc. Develops medical diagnostic technologies Advanced Research Instruments to medical and spa professionals. Littleton 52 Biotechnology, Pharmaceutical and for research and clinical applications. Corporation www.allisonmedical.com The primary focus is a rapid, integrated Related Companies Golden Aestis Inc. Develops products to assist specialists bacterial analysis system designed to www.aricorp.com Boulder in the medical and veterinary industries 63 Biofuels and Related Companies identify, count and provide complete Produces preamplifiers for PMT’s and www.aestis.com and has designed and provided essential 65 Research & Education Institutions antibiotic susceptibility data by bacterial electron multipliers, high voltage power Develops a treatment for obesity through syringes, needles and custom items for species within a few hours of sample 68 Foundations supplies, counters and timers, precision controlled hypoxia technology. The two various industries. injection without prior culturing. rate meters and image analyzers for principal components are the air separation 69 Service Providers scanning electron microscopes. unit and the proprietary control system. Accu-Tube Corporation Englewood Medical Device About Packaging Robotics www.accutube.com and Related Companies Thornton www.aboutpackagingrobotics.com Manufactures standard and custom Abilities Unlimited Produces robotic package handling size stainless steel hypodermic medical Colorado Springs, Denver systems. The products are engineered to tubing. www.auiop.com open, fill, transport, seal, code and label Provides artificial limbs and custom a variety of pre-made pouches and bags. Actall Security Products orthopedic appliances. Their line of packaging and systems for Denver on-demand product identification are www.actallsp.com Able Planet currently used in the medical, industrial Engineers, manufactures and markets Lakewood and food industries. wireless systems for hospital and www.ableplanet.com pharmaceutical company facilities. Provides products for people with all Accellent levels of hearing loss. Arvada, Englewood ADA Technologies Inc. www.accellent.com Littleton AbleLink Technologies Offers a comprehensive menu of www.adatech.com Colorado Springs outsourcing solutions to the medical Designs and manufactures prosthetic and www.ablelinktech.com device market, including innovative orthotic components. Addresses the need for well-researched design, integrated engineering, precision cognitive support technologies for component production, finished goods Advanced Cosmetic Intervention individuals with intellectual disabilities. assembly and complete supply chain Centennial management. www.acisurgery.com Develops innovative devices and minimally invasive techniques for the medical and cosmetic industry.

38 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 39 AlloSource Analog Scientific LLC Apdyne Medical Company Avantes Bell Dental Products LLC BioVision Technologies Inc. Centennial Louisville Denver Broomfield Denver Golden www.allosource.com www.analogscientific.com www.apdyne.com www.avantes.com www.belldental.com www.biovisiontech.com Develops, processes and Commercializes devices that will Manufactures and distributes the Produces, develops and sells Designs, develops and manufactures Develops and manufactures micro- distributes life-enhancing bone reduce and discourage anesthetic/ Apdyne Phenol Applicator Kit used to spectrometers, light sources, fiber optic precision dental equipment based on visualization solutions that enable and tissue allografts to the medical narcotic analgesic abuse. anesthetize the tympanic membrane multiplexer, fiber optic cables, software, electric motor technology. endoluminal and minimally invasive community. during in-office myringotomy fiber optics and accessories to the medical procedures in both human Animal Care Systems procedures. medical device industry. BioCare Systems Inc. and veterinary medicine. The imaging AllPro Littleton Parker technologies and customized micro- Broomfield www.animalcaresystems.com Aqueous Biomedical Bal Seal Engineering www.biocaresystems.com endoscope solutions are integrated www.allprodental.com Provides innovative rodent caging Colorado Springs Colorado Springs Designs, develops and markets patent- to reduce incision size and speed healing. Produces a large selection of non- systems for the life science www.aqueousbio.com www.balseal.com protected, FDA cleared, new health-care latex prophy cups, prophy angles industry. Develops biocompatible materials Produces seals and canted-coil springs for devices (LumiWave™) that use deep-tissue bioZhena Corporation and other dental products. and geometric designs that can be sealing, holding, latching and electrical light therapy to decrease pain, accelerate Bellvue Animark applied to stents, shunts, artificial contact in a variety of applications healing and improve quality of life. [email protected] Alpha Mold West Aurora organs and drug delivery devices. throughout the medical market. Develops devices and informatics Broomfield www.animark.us Their first product, the Oculieve™ Biodesix Inc. products focused on female reproductive www.alphamoldwest.com Manufactures and sells ultrasound shunt, is designed to control over- Baxa Corporation Boulder health management, including conception Plastic injection mold-making pregnancy detectors and ovulation pressurization inside the eye caused Englewood www.biodesix.com aid, birth control, ovulation, screening for facility for the medical industry. predictors for livestock breeding. by glaucoma. www.baxa.com Provides clinically reliable methods for cancer and other conditions of the female Develops and manufactures products the early detection, diagnosis, therapeutic reproductive system. ArcScan Inc. for preparing, handling, packaging and guidance and monitoring of cancer and Morrison administering fluid medications. degenerative diseases. Boulder Innovation Group Inc. www.arcscan.com Boulder Redevelops and sells the new Artemis Beacon Biotechnology Biofeedback Systems Inc. www.boulderinnovators.com 3 ArcScanner for refractive surgery Denver Boulder Develops and manufactures image- and implants. www.beaconbiotechnology.com www.users.qwest.net/~pitchj guided surgical navigation digitizers and Arvada BP Proteomics, ProLume Ltd. and Black Designs, manufactures, sells and industrial 3D capture and ARP Manufacturing LLC Forest Engineering LLC have come services a line of biofeedback hardware modeling equipment. Centennial together to create Beacon Biotechnology and software including subliminal and www.arpwave.com to pursue new opportunities that build supraliminal audio self-help cassette Braun BioSystems Uses a patented bio-electrical current, upon their respective scientific expertise. programs. The company is an FDA- Centennial simultaneously with active range-of- registered medical device manufacturer. www.braunbiosystems.com motion and other exercise techniques, Provides diagnostic point-of-care COLORADO Beam One LLC to significantly speed up the body’s Denver BIOPTIX LLC coagulation management systems natural recuperative ability. www.beam-one.com Boulder that have a positive impact on patient Make a home for your business. In Arvada, Offers electron beam sterilization for www. bioptix.com outcomes in hospital, outpatient and your business can benefit from a skilled workforce, proximity to leading Auri-Stim Medical medical and pharmaceutical devices. Develops technologies to detect trace home health care venues. universities and research institutions, and a thriving business climate— Denver amounts of bacteria, viruses, proteins, all in a community that feels like home. To learn more about what www.net1device.com Beckman Coulter nucleic acids, antibodies and human Broadwest Corporation makes us different, visit www.aeda.biz Offers an alternative therapy for Fort Collins micro RNAs. Denver migraine headaches, hormonal www.beckmancoulter.com www.broadwest.com migraine, chronic headaches, Develops and produces instruments for Bio-Logistics Preclinical Inc. Develops and manufactures ergonomic premenstrual syndrome (PMS) and the diagnostic industry. Specializes in Pierce mammography viewing equipment. nicotine and narcotics addictions the fields of immunocytochemistry, flow www.bio-logistics.com 720 . 898 . 7010 8101 Ralston Road, Arvada, Colorado 80002 using the NET-1000 device. cytometry and microbiology. Offers engineering and regulatory support and preclinical strategic development to the medical device industry.

40 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 41 C5 Medical Werks Carsan Engineering Inc. Clarimedix Inc. COMEG U.S.A. Endoscopy Inc. Crosstrees Medical Inc. Delphi Medical Systems Grand Junction Golden Boulder Denver Boulder Longmont www.c5medicalwerks.com www.carsaneng.com (303) 905-6163 www.comeg.de/eng www.xtreesmed.com www.delphimedical.com Offers ceramic manufacturing, materials Designs and manufactures products Develops quantum devices for the Develops and manufactures high-grade Develops surgical instruments for the Manufactures infusion, respiratory and expertise and custom engineering support for several of the leading OEMs temporary relief of minor muscle and endoscopes and accessories. treatment of vertebral compression vital signs monitoring equipment. to prototype and commercialize designs in the medical, dental, industrial, joint pain, arthritis, muscle spasms and fractures of the spine. and patents to orthopedic companies for semiconductor, entertainment and video stiffness. Confi-Dental Products Company Denver Instrument Company hip, spinal and dental implants. projection markets. Louisville CytoLogic Denver Clean Room Devices LLC www.confi-dental.com Fort Collins www.denverinstrumentusa.com Canberra Industries CEA Technologies Inc. Westminster Manufactures dental cements, composite www.cytologic.com Designs and manufactures analytical Greenwood Village Colorado Springs www.cleanroomdevices.com resins and injection-molded plastics. Develops a medical device to treat solid balances, electrochemistry instruments, www.canberra.com www.ceatechnologies.com Manufactures products that are tumors. UNLEASH™ Immunotherapy moisture analyzers and titration Manufactures and supplies analytical Provides product development and engineered specifically for clean room ConMed Electrosurgery selectively removes blood-borne controllers. instruments, systems and services complete product assembly and environments. Centennial inhibitors that protect tumors from the for radiation detection and radiation packaging services to the medical www.conmed.com body’s own immunological defenses. Denver Optic Company monitoring. industry. Cobe Sterilization Services Designs and manufactures RF Englewood Lakewood electrosurgical generators and accessories DALSA Colorado Springs www.eyeprosthetics.com Care Electronics Inc. CeraPedics Inc. (303) 205-2564 for use in surgical procedures. Colorado Springs Specializes in the fitting and fabrication Boulder Lakewood EtO (ethylene oxide) sterilization facility www.dalsa.com of two types of ocular prosthesis. www.medicalshoponline.com www.cerapedics.com with services offered to third party CoorsTek Designs, develops, manufactures and Offers a range of electronic monitoring Develops and commercializes products customers. Has fulfilled requirements for Golden markets digital imaging products and Desert Glass Works and alarm equipment for the home health for the orthopedic bone substitute market. EPA, FDA, ISO and OSHA compliance. www.coorstek.com solutions. Products are components in Colorado Springs and long term care markets. Manufactures over 150 ceramic blends equipment for digital x-ray equipment www.dgw.com Certol International LLC Cochlear Americas for use in implant procedures. Also, and DNA-based laboratory test Manufactures quartzware for the medical CARIDIAN BCT (formerly gambro bct) Commerce City Englewood offers over 18,000 plastic materials for equipment. and research industries. Lakewood www.certol.com www.cochlearamericas.com projects including high-temperature www.caridianbct.com Provides cleaning, disinfection and Designs, manufactures and distributes polymers, thermoplastics, fluoropolymers Darkhorse Technologies Die Cut Technologies Inc. Develops and manufactures automated sterilization products and solutions to hearing implants including the Nucleus and bioresorbables and provides custom Boulder Northglenn blood collection systems and related address the complicated infection control Freedom and Baha implants. machined and injection-molded metals. [email protected] www.diecuttech.com information systems. Developing challenges within the medical and dental Commercializes a patented technology Offers precision material conversion, cancer therapies and vaccines through markets. Colorado Laser Marking Inc. Corgenix Medical Corporation for affordable, hand-carried, battery- skilled assembly and manufacturing therapeutic apheresis and cell therapy. Colorado Springs Broomfield operated instruments for on-site genetic efficiencies, including clean room Developing pathogen reduction Chalfant Research and Development www.coloradolasermarking.com www.corgenix.com detection using Polymerase Chain facilities. technologies. Colorado Springs Provides laser engraving technology, Develops and manufactures innovative Reaction (PCR). (719) 473-7499 CO2 laser cutting services and metal medical diagnostic products in the Directed Energy Solutions Caroba Plastics Inc. Manufactures electronic controls, photographic reproduction to the medical hemostasis, autoimmune and vascular DataWave Technologies Corporation Colorado Springs Englewood semiconductors and medical devices. device industry. areas. Berthoud www.denergysolutions.com www.caroba.com Provides control circuit design and www.dwavetech.com Develops advanced laser and optical Provides custom injection molds and fabrication for semiconductor, medical, Colorado Precision Products Inc. Covidien Manufactures a wireless and battery-free device solutions for medical applications. specializes in the needs of the medical printing and machining industries. Boulder Boulder device for acquiring and transmitting and high technology industries. www.coloradoprecision.com www.covidien.com data from electrodes and other biosensors DNTLworks Equipment Corporation Chart Denver Provides diamond-turned and polished Offers an extensive product line, to a receiver placed meters away for Centennial Denver optics/parts. Fabricator of X-ray telescope including pulse oximetry and airway electrophysiology-, neurophysiology- www.dntlworks.com www.cryenco.com optical components. Produces and and temperature management devices, and physiology-related research on both Manufactures portable, mobile and self- Provides contract manufacturing services offers air bearing LVDT contact linear ventilators, vessel sealing and humans and large animals. contained dental systems. to the medical equipment industry. measurement systems, .05 microinch electrosurgery equipment. resolution.

42 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 43 dpiX Inc. Encision Inc. Firefly Medical Inc. Global Med Technologies Hosuk America Instec Inc. Colorado Springs Boulder Fort Collins Lakewood Aurora Boulder www.dpix.com www.encision.com www.fireflymedical.com www.wyndgate.com www.hosuk.net www.instec.com Produces high-resolution amorphous Designs and manufactures innovative Designs and develops innovative durable Develops and supplies blood bank Manufactures syringes and packaging Manufactures precision temperature silicon (a-Si) sensor arrays for medical surgical devices. Developed AEM® medical equipment for clinical health management information systems and products for the medical community. controllers and microscope hot stage X-ray imaging. Laparoscopic Instruments to improve care markets. services for blood centers and hospitals. systems for temperature cycling, food electrosurgery and reduce the chance ibalance Medical Inc. sciences, materials characterization, E-I Medical Imaging of patient injury in minimally invasive Fischer Medical Technologies Inc. Gnathodontics Ltd. Boulder forensics, polymers and liquid crystals Loveland surgery. Northglenn Wheat Ridge www.ibalancemedical.com and microbiology. www.eimedical.com www.fischermti.com www.gnatho.com Develops a solution for knee Develops veterinary diagnostic Encynova International Designs, manufactures and markets Specializes in functional dentistry, malalignment that preserves and Integrity Manufacturing ultrasound. Greeley imaging systems for the screening and advanced implant work, precision partial restores natural knee surfaces. The Axial Colorado Springs www.encynova.com diagnosis of breast cancer. dentures, combination cases and metal- Knee Realignment System (AKRFX) (719) 381-4380 E.N. Murray Designs and manufactures fluid control free fixed restorations. comprises both a new surgical technique Produces precision metal products for the Denver systems for a broad range of metering Fluonic and an anatomic-based knee implant medical industry. www.enmurray.com and dispensing applications. Boulder Great Basin Scientific system. Develops cellular foam technology for www.fluonic.com Boulder Intertek the medical device industry. EndoShape Inc. Develops infusion therapy systems www.gbscience.com InDevR Inc. Boulder Boulder with disposable sensors for OEM and Founded to provide health care Boulder www.intertek.com Eldon James Corporation www.endoshape.com proprietary pumping systems. professionals with fast, accurate, cost- www.indevr.net Offers testing, inspection and certification Loveland Manufactures surgical and medical effective and easy-to-use diagnostic test Develops and manufactures biomedical of products, commodities and systems for www.eldonjames.com instruments focusing on shape memory Gambro (formerly gambro RENAL PRODUCTS) in the point-of care setting. instruments including molecular medical devices. Performs FDA 510(k) Designs and manufactures a diverse line polymer devices for endolumenal Lakewood diagnostic assays, virus measurement reviews, electrical safety certification of plastic and stainless steel hose fittings application. www.usa-gambro.com Hach Company systems and detection technologies for including CE Marking, testing to the with a single-barb design. Develops and supplies hemodialysis, Loveland micro-arrays. MDD and IVDD, risk analysis, EMC and Evergreen Research Inc. peritoneal dialysis and acute dialysis www.hachultra.com performance testing. Electronic Materials Inc. Golden products, therapies and services. Manufactures and distributes analytical Infinity Photo-Optical Company Breckenridge www.evergreenresearch.com instruments and reagents used to test Boulder IPAX Inc. www.emiuv.com Offers a complete range of development GE Analytical Instruments the quality of water and other aqueous www.infinity-usa.com Englewood Offers a complete line of EMCAST UV services from product definition and Boulder solutions. Manufactures long-distance and www.ipaxinc.com adhesives, epoxies, sealants, encapsulants feasibility studies through detailed design www.geinstruments.com/ionics continuously-focusable microscope Assembles and packs medical products. and coatings. EMI also offers room to pilot-run and low-volume production Manufactures instruments used to HEI Advanced Medical Operations technology, macro systems, internal- temperature, thermal and visible light to the medical device industry. measure total organic carbon (TOC) in Boulder focusing devices and other lenses. Jorgensen Laboratories Inc. cure adhesive systems. water for pharmaceutical applications and www.heii.com Loveland Extreme Diagnostics medical research. Develops and manufactures high Injectech LLC www.jorvet.com Ellab Inc. Boulder performance components, medical Loveland Designs and manufactures instruments Centennial www.extremediagnostics.com Genesee BioMedical Inc. software, medical devices and non- www.injectech.net which are used in the animal health field www.ellab.com Develops noninvasive measurement Denver medical products. Produces microcircuits Provides molding, assembly and design including specialty instruments, surgical Manufactures thermal validation solutions systems, including optical systems www.geneseebiomedical.com and subsystems for hearing and medical of medical components and fittings suture and veterinary equipment. for food and pharmaceutical industries. such as custom holographic and Manufactures cardiac surgery applications. for OEM device manufacturers. Class interferometric instruments. Specializes instruments and devices. 100,000 cleanroom molding and Kestrel Labs Inc. Empirical Testing Corporation in structural health monitoring, Hirsh Precision Products Inc. assembly available. Boulder Colorado Springs nondestructive testing and materials Boulder www.kestrellabs.com www.empiricaltesting.com processing. www.hppi.com Researches and develops projects; Provides medical device testing services Manufactures precision-machined and provides consulting and provides contract that add value throughout the product assembled components for the medical development of patient monitoring development cycle, with a focus on spinal industry. systems and other medical technologies. implant device testing.

44 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 45 Kimble Precision Inc. Locomotion Inc. Medical Modeling Inc. MicroPhage Inc. NanoProducts Corporation Optibrand Ltd. LLC Loveland Nederland Golden Longmont Longmont Fort Collins www.kimble-precision.com (303) 596-5141 www.medicalmodeling.com www.microphage.com www.nanoproducts.com www.optibrand.com Provides general machining, short Develops a patented technology Produces highly accurate 3-D physical Produces high-speed bacteria detection Provides performance-oriented product Provides a fraud-resistant system to run production of existing products, addressing a critical need in the process models of human bone structure from technologies to commercialize in markets engineering, followed by manufacturing positively identify animals from birth and prototyping of new products, as well as of providing walking therapy to brain imaging such as CT or MRI. including: food safety, water safety, and delivering nanoscale materials, throughout the food processing chain. fixturing and tooling. injury patients. clinical and veterinary diagnostics and dispersions and related products for The Secure Identity Preservation system Medivance Inc. detection applications. medical materials. helps assure food safety and control the Lanx LLC Logisens Corporation Louisville spread of animal disease. Broomfield Fort Collins www.medivance.com Mikron Corporation Denver NeuroQuest Therapeutics www.lanx.us www.logisens.com Produces therapeutic temperature Aurora Grand Junction Otologics LLC Develops surgical spinal technologies. Develops biosensor and software management systems. www.mikron.com www.nqtherapeutics.com Boulder technology, enabling a significant Supplies transfer machining systems for Develops an electric brain-stimulating www.otologics.com Laser Neurotherapy Development breakthrough in real-time measurement Medtronic Navigation complex parts, cutting tools with high device to deliver neuromodulation Develops and commercializes surgically Labs Inc. and reduction of stress. Louisville performance standards, self medication treatments to address the unmet implantable alternatives to conventional Colorado Springs www.medtronicnavigation.com and diagnostic devices. therapeutic needs of nervous system “in the ear” hearing aids. www.laserneurotherapy.com Magnelab Inc. Delivers surgical navigation and intra- disorders, stroke recovery, chronic pain Develops and distributes health care Longmont operative imaging solutions. Mind Studios and behavioral disorders. Oval Window Audio solutions based upon high energy laser www.magnelab.com Colorado Springs Nederland technologies that direct high level, Manufactures magnetic components Meinhard Glass Products www.mind-studios.com Norgren Inc. www.ovalwindowaudio.com monochromatic, continuous-wave optical (transformers/inductors) for the medical Golden A full service product design and Littleton Produces induction loop assistive radiation to pathological tissue to restore field. www.meinhard.com research studio housed within the www.norgren.com/usa listening systems and visual and and improve function. Produces nebulizers for use in all major University of Colorado at Colorado Produces miniature valves, pressure vibrotactile technologies that help deaf Massively Parallel ICP instruments. Springs. Offers concept generation, regulators, proportional technology, and hard-of-hearing individuals. Leeds Precision Instruments Inc. Technologies Inc. advanced prototyping, engineering and medical gases and liquids for the medical www.leedsmicro.com Louisville Mesa Laboratories Inc. consumer research, human factors design device industry. Pare Surgical Inc. Offers microscopes and custom- www.massivelyparallel.com Lakewood and manufacturing solutions. Englewood engineered products ranging from small Develops software that allows researchers www.mesalabs.com nSpire Health Inc. www.paresurgical.com modifications on a microscope stand that to conduct protein searches 26 times Provides dialysis meters and related MKS Instruments, Medical Electronics Longmont Develops surgical instruments such as the accommodate specific applications, to faster than jobs submitted through the supplies to dialysis clinics worldwide. Colorado Springs www.nspirehealth.com Quik-Stitch endoscopic suturing system. large specialized systems, such as an National Center for Biotechnology www.mksinst.com Develops, manufactures and markets optical comparison bridge for forensic Information’s Web site. Metafluidics Inc. Manufactures power generators and respiratory care products and services Parker Medical science. Golden amplifiers for medical applications. focused on cardiopulmonary diagnostics, Englewood mBio Diagnostics www.metafluidics.com respiratory core lab services and disease www.parkermedical.com Lenox MacLaren Surgical (a division of Precision Photonics Corporation) Delivers cytometry and cell sorting Mountainside Medical management solutions. Provides airway management products. Instruments Boulder solutions using optical trapping, Boulder Louisville www.precisionphotonics.com fluorescence detection and fluid control www.mountainsidemed.com Olympus Soft Imaging Solutions Particle Measuring Systems www.lenoxmaclaren.com Develops a low-cost, high sensitivity, technology. Specializes in the contract manufacturing Corporation Boulder Manufactures precision orthopedic and multi-pathogen detection system for of medical device components and Lakewood www.pmeasuring.com neurological surgical instruments. diagnostics. Metamatrix LLC instruments, including electrosurgical www.soft-imaging.de Designs, manufactures and services Boulder and laparoscopic instruments and jaws, Produces, markets and sells image precision microcontamination monitoring Lexicor Medical Technology LLC MedEfficiency Inc. www.zorbent.com orthopedic implants and endoscopy acquisition and processing software instrumentation and software used for Boulder Westminster Manufactures an all-purpose absorbent devices. and hardware for all areas of electron detecting particles in aerosols, liquids, www.lexicor.com www.medefficiency.com called Zorbent. microscopy. slurries, gas streams and vacuum Develops neuropsychiatric medical Specializes in total contact casting processing environments as well as devices. products for off-loading diabetic foot surface molecular contamination ulcers. monitoring.

46 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 47

PCC/Advanced Forming pico-tesla Magnetic Therapies Prescott’s Inc. RJD Machining Sandhill Scientific Technology Littleton Monument Parker Highlands Ranch Longmont (303) 795-3222 or www.surgicalmicroscopes.com www.rjdmachining.com www.sandhillsci.com www.pcc-aft.com [email protected] Provides reconditioned operating Specializes in precision production runs Designs, manufactures and Offers thixoforming and metal injection Manufactures, markets and supports microscopes and allied accessories that and some prototype work for OEMs in distributes diagnostic products molding for the medical device industry. proprietary medical device technology function as intended by the original the medical industry. focused on gastroenterology. designed to treat the signs and symptoms equipment manufacturer. Peak Robotics Inc. of neurological disorders like Parkinson’s Rocky Mountain Biosystems Inc. Scientech Inc. Colorado Springs disease, Alzheimer’s, migraines and Probetronix LLC Wheat Ridge Boulder www.peakrobotics.com epilepsy. Colorado Springs (303) 277-1140 www.scientech-inc.com Manufactures robots, special equipment www.probetronix.net Develops a tissue sealing technology that Manufactures analytical instruments: and turnkey automated systems for a Plexus Corporation Manufactures oscilloscope probes. Quest Product Development activates a specially formulated adhesive semi-micro balances, analytical variety of industries including: biotech, Louisville Corporation to bond tissue and achieve a uniform balances, semi-analytical balances electronics, medical, semiconductor and www.plexus.com Products Group International Inc. Wheat Ridge seal in seconds. The systems temporarily and toploading balances for the others. Provides integrated product development, Lyons www.quest-corp.com or permanently modify tissues for medical industry. manufacturing and sustaining services of www.productsgroup.com Helps bring to market medical products transdermal and deposition drug delivery Peddle Master Inc. medical products. Researches, develops and engineers and analytical systems for small start-ups and for cosmetic skin resurfacing. Scott Orthotic Labs Inc. Johnstown ultrasound medical and veterinary to research universities and international Fort Collins www.peddlemaster.com Porta-Lung Inc. equipment. corporations. Rocky Mountain Instrument Company www.scottorthoticlabs.com Designs and manufactures handicapped Lakewood Lafayette Manufactures orthotic and prosthetic driving aids. www.portalung.com Protogenic Inc. Radiological Imaging Technology www.rmico.com products. Provides non-invasive ventilator support Westminster Colorado Springs Designs and manufactures optics and Pernicka Corporation for long-term patients who need more www.protogenic.com www.radimage.com coatings (ultraviolet through far infrared) Sealcon Fort Collins portability than the iron lung allows, Manufactures prototypes and conceptual Provides clinical and research physicists for the medical industry. Centennial www.pernicka.com while maintaining the same level of models using stereolithography) and Laser with a high precision automated QA www.sealconusa.com Offers analytical testing that meets or ventilating efficiency. Sintering rapid prototyping technology. tool for advanced radiation therapies. Rocky Mountain Orthodontics Inc. Manufactures cable management exceeds the requirements of MIL-STD Received FDA clearance on RIT113 Denver components, including liquid tight 750/883 method 1018 and 45662A Precision Diagnostic Instruments Protomed Inc. radiation therapy film dosimetry. www.rmortho.com strain relief fittings, flexible conduit, for companies in the semiconductor, Westminster Arvada Serves all areas of orthodontics including M23 circular connectors and related aerospace, basic and applied research, www.pdimeters.com www.protomed.net Rand-Scot Inc. pediatric orthodontic prevention, products for the health care industry. surface analysis, thin film deposition, Designs and manufactures professional Creates accurate anatomical models from Fort Collins interceptive pediatric orthodontics, laser technology and medical products quality, affordable test equipment. CT scans by using the latest imaging www.easypivot.com mixed dentition orthodontics, adult Shippert Medical Technologies industries. software and laser-driven technology. Designs and manufactures products orthodontics, reconstructive dentistry Centennial Precision Glassblowing for persons with disabilities including orthodontics, TMJ orthodontics, surgical www.shippertmedical.com PharmaJet Inc. Centennial Prototype Casting Inc. BBD Cushions and Mattress Overlays, orthodontics and breathing/sleep Manufactures and distributes medical Golden www.precisionglassblowing.com Denver EasyPivot Patient Lifts and Saratoga problem-related orthodontics. disposable products and instruments. www.pharmajet.com Provides custom and OEM www.protcast.com Exercise Products. Serves the ear, nose and throat, Develops a needle-free technology that scientific glass for custom synthesis, Manufactures non-ferrous prototype parts Samson Design Associates Inc. plastic surgery, cosmetic surgery, has a low cost, single use, disposable pharmaceutical, environmental, for the medical industry, specializes in Rapid Prototying Corporation Boulder emergency/trauma care, family polypropylene vial or cartridge, suitable petrochemical, research, commercial, RPM (Rubber Plaster Mold) casting, sand Longmont www.samsondesign.com practice, pediatric, ophthalmology for the delivery of common vaccines and government and medical laboratories. casting and rapid investment casting. www.rapidpro.com Provides full service product and dermatology fields. standard dose injectable liquid medicines. Offers engineering and design and other development ranging from concept to Preferred Medical Products Inc. PTA Corporation manufacturing services for the medical production specifications, with many Englewood Longmont device industry. products for the medical field. www.pmpcolorado.com www.ptacorp.com Manufactures stainless steel medical Manufactures aluminum and steel molds components for hypodermic needles and for projects with lifetime runs of 5,000 to lancet type products. 250,000 pieces for medical applications.

48 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 49 Sienco Inc. Sound Surgical Technologies LLC Summa Design Synthes Inc. Tech-X Corporation TMJ Implants Inc. Arvada Louisville Montrose Monument Boulder Golden www.sienco.com www.vaser.com www.summa-design.com www.synthes.com www.txcorp.com www.tmj.com Manufactures and distributes Class II Offers ultrasonic technologies and related Contract design and development Develops, produces and markets Specializes in scientific and ngineering Designs and manufactures alloplastic medical devices, disposable supplies, techniques for aesthetic surgery. company focused on the medical device instruments, implants and biomaterials software, including visualization and implants for the treatment of reagents and accessories for in-vitro market. for the surgical fixation, correction and algorithm development. temporomandibular joint disorders and diagnostic use. Also, provides tools for Source MDx regeneration of the human skeleton and injuries. hemostasis monitoring and viscoelastic Boulder Summit Doppler Systems its soft tissues. Tensegrity Prosthetics Inc. evaluations. www.sourcemedicine.com Golden Boulder Toltec International Inc. Develops RNA-based biomarkers to cre- www.summitdoppler.com T.R.S. Inc. www.tensegrityprosthetics.com Lakewood Snoasis Medical ate companion diagnostics for inflamma- Manufactures ultrasound Doppler Boulder Develops a prosthetic foot that mimics www.toltec.biz Denver tion- related therapeutic areas including systems used to detect fetal heartbeat and www.oandp.com/products/trs the functional biomechanics of the Provides medical device R&D www.snoasismedical.com oncology, cardiovascular, autoimmune to monitor peripheral arterial and venous Develops, manufactures and markets human foot in walking. engineering services that are compliant Develops dental regenerative products and infectious diseases. blood flow. body-powered prosthetic devices. with FDA and international regulatory derived from discarded tissues and cells. Designs and builds technology for The Harloff Company standards. Spectranetics Sunrise Medical persons who are missing hands. Colorado Springs SomaLogic Inc. Colorado Springs Longmont www.harloff.com Transtracheal Systems Inc. Boulder www.spectranetics.com www.sunrisemedical.com Tapeless Wound Care Manufactures and sells a line of crash Englewood www.somalogic.com Develops, manufactures and markets Provides home health care products Products LLC carts, medication carts and other specialty www.tto2.com Uses aptamer array technology and single-use medical devices used in including wheelchairs, respiratory, daily Englewood carts for hospitals, nursing homes, clinics Develops and manufactures innovative bioinformatics capabilities to discover minimally invasive surgical procedures living aids and speech augmentation www.tapelesswoundcare.com and surgery centers. respiratory therapy products that advance disease-specific biomarkers and protein within the cardiovascular system along devices. Manufactures and distributes a system medical therapy for persons requiring signatures. Develops medical diagnostics with its CVX-300® excimer laser system. of patented secondary wound dressing The Phoenix Group continuous supplemental oxygen, based on these signatures. Supreme Cable Technologies Inc. retention devices, offering an alternative Denver including the SCOOP transtracheal Spectrum Laser and Technologies Inc. Thornton to traditional secondary wound dressings, www.labaconline.com oxygen therapy system. Sonora Medical Systems Inc. Colorado Springs www.supremecable.com for both human and animals. Designs and builds high quality, innovative Longmont www.spectrumlaser.com Manufactures quality custom cable quadriplegic seating systems and Trelleborg Sealing Solutions Mountain www.4sonora.com Provides contract design and assemblies and wire harnesses. Tartan Orthopedics Ltd accessories (Falcon Rehabilitation Products, Broomfield Provides high quality products and manufacturing services for the medical Northglenn LaBac Seating Systems, Gel Ovations). www.trelleborg.com/en services to the diagnostic ultrasound and industry. Surgical Pioneering www.tartanortho.com Supplies high-quality products and MRI markets. ISO 9001 certified and Monument Manufactures sacro lumbar belts, dorsal TheraTogs Inc. solutions for industrial sealing and FDA registered. StrionAir Inc. (303) 333-4333 lumbar belts (corsets and moldable Telluride bearing systems. Activities are focused in Louisville Develops instrumentation and methods inserts), Ottenberg-style elbow splints, www.theratogs.com many business areas including the food Sontec Instruments www.strionair.com to improve surgery with an emphasis on pelvic traction belts, arm slings, cervical Produces an orthotic undergarment and and pharmaceutical industries, as well as Centennial Manufactures and markets a product cardiac surgery. collars, acromioclavicular splints and strapping system that gives clients with medical engineering. www.sontecinstruments.com that uses disposable media and that can ankle supports. sensorimotor impairment a new modality Provides a broad line of instruments as be installed in any air handler or HVAC The Synaptic® Corporation for improving postural alignment and Ultrathera Technologies Inc. well as custom instrument manufacturing system. Aurora TDA Research Inc. stability. Colorado Springs and in-house repair service. www.synapticusa.com Wheat Ridge www.ultrathera.com Stroke Recovery Systems Inc. Develops Synaptic®, a patented pain www.tda.com Tissue Genetics Inc. Created the Vestimumax, a machine that Sorin Group (formerly Cobe Cardiovascular) Denver control technology that works without Provides automated catalyst testing Aurora turns, twirls and shifts its occupant in two Arvada www.strokeaid.com drugs. Marketed in accordance with FDA equipment to large chemical companies www.tissuegenetics.com directions, so they can spin horizontally www.cobe.com Develops the AutoMove AM800 that regulations for the treatment of acute and and national laboratories. Molecular diagnostics company with and vertically at the same time. Uses Develops and produces cardiovascular teaches healthy parts of the brain after a chronic pain. unique technology for improving the care include treatment for cerebral palsy- and autologous transfusion therapy stroke to take over lost functionality. of patients with genetic diseases using related symptoms, problems with inner- products. biomarkers to identify patients by with ear balance and torso strength for sitting, hereditary diseases and to determine the crawling and standing. course of care.

50 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 51 Value Plastics Inc. Westone Laboratories Affinity Bioreagents Alpharma Inc. Aquatic BioSystems Biotechnology, Pharma and Related Fort Collins Colorado Springs Golden Longmont Fort Collins Companies www.valueplastics.com www.westone.com www.bioreagents.com www.alpharma.com www.aquaticbiosystems.com Designs and manufactures plastic tubing Designs and manufactures custom 3QMatrix Offers over 35,000 research reagents Manufactures generic liquid and Specializes in the production and fittings and connectors. earmolds for hearing health care and Boulder for 43 research areas as well as custom topical pharmaceuticals including distribution of freshwater and marine other applications. www.3QMatrix.com antibody production services. nutritional supplements, water- organisms for aquatic toxicology, ValveXchange Inc. Focuses on the development and soluble pharmaceutical products biomonitoring and other research Aurora Wi Inc. commercialization of novel wound Agilent Technologies and disinfectants for veterinary activities. www.valvexchange.com Englewood healing products as well as transndermal Boulder use. Develops a bioprosthetic heart valve with www.wiinc.net and subcutaneous slow release drug www.agilent.com ARCA biopharma a percutaneously-exchangeable leaflet Designs and engineers medical devices. delivery. Agilent Nucleic Acid Solutions American Allied Biochemical Inc. Broomfield set that provides lifetime service without develops and manufactures therapeutic Aurora www.arcabiopharma.com anti-coagulation therapy. Ximedix Inc. Accera Inc. oligonucleotide in a multi-product, www.aablabs.com Specializes in developing and Colorado Springs Broomfield 33,500 square foot facility. Specializes in the purification commercializing genetically-targeted Vibe Technologies www.ximedix.com www.accerapharma.com and distribution of restriction therapies for heart failure and other Greeley Manufactures and sells single patient Discovers and develops innovative Agripro COKER endonucleases enzymes. cardiovascular diseases. www.vibemachine.com use medical products for the anesthesia, therapeutic treatments for Berthoud Offers a vibrational integrated bio- respiratory care, critical care and neurodegenerative diseases, such as www.agriprowheat.com Amgen Inc. Array BioPharma photonic energizer device that brings the emergency medicine applications. Parkinson’s disease, Alzheimer’s disease Develops and delivers superior wheat Boulder, Longmont Boulder, Longmont vibrational level of a person’s body back and other age-related memory loss seed genetics in North America. www.amgen.com www.arraybiopharma.com to its natural state. Yamato Corporation disorders. Discovers, develops, Discovers, develops and commercializes Colorado Springs AKTIV-DRY manufactures and markets human targeted small molecule drugs to treat VitruMed Inc. www.yamatocorp.com Accuthera Inc. Boulder therapeutics based on advances debilitating and life-threatening diseases Boulder Manufactures and sells weighing Conifer www.aktiv-dry.com in cellular and molecular biology. such as cancer. www.vitrumed.com equipment and systems for medical (303) 697-1427 Provides dry powder processing solutions Amgen Colorado is one of the Focuses on improving methods of soft facilities. Develops therapeutics for acute and for the vaccine, pharmaceutical and company’s key operations centers, AspenBio Pharma Inc. tissue management in surgery specific to critical care indications. Initial clinical biotechnology industries. providing EPOGEN®, Aranesp® Castle Rock the resection and biopsy of pathologic Zetek Inc. indication is acute lung injury caused and Kepivance™. www.aspenbioinc.com tissue. Aurora by trauma and/or serious infectious Albany Molecular Research Inc. (AMRI) Discovers, develops, manufactures and www.zetek.net pathogens. Denver ApopLogic Pharmaceuticals LLC licenses products primarily for animal WalkMed Infusion LLC Manufactures the OvaCue family of www.amriglobal.com Aurora health care with a growing pipeline Wheat Ridge ovulation prediction products. ADMEQuant Bioanalytical Services Assists pharmaceutical companies on the www.apoplogic.com including recombinant hormones and www.walkmed.net Colorado Springs molecular level with the development and Develops biotech drugs that take diagnostic tests. Offers solutions for ambulatory infusion Zynex Medical Inc. www.admequant.com manufacturing for new small molecule advantage of understanding the therapy and pain management. Littleton Specializes in bioanalytical and prescription drugs. receptors and ligands that control Aspire Biotech Inc. www.zynexmed.com metabolism research studies for the natural cell death (apoptosis). Colorado Springs WestMed Inc. Offers electrotherapy products, utilizing pharmaceutical and biotechnology, Allos Therapeutics Inc. www.aspirebiotech.com Greenwood Village various methods of non-invasive muscle animal health and agricultural industries. Westminster APRO Bio-Pharmaceutical Provides contract services for all phases www.westmedinc.com stimulation and electromyography www.allos.com Corporation of product development from concept to Designs, manufactures and markets technology, Interferential Current (IFC) Advanced Metabolic Develops and commercializes small Englewood launch and produces its own skin sealant medical devices to anesthesia and and Transcutaneous Electrical Nerve Laboratories LLC molecule therapeutics for the treatment (303) 867-3415 and wound-closure adhesives. respiratory care professionals. Stimulation (TENS). Aurora of cancer. Develops novel drugs that may www.AdvancedMetabolicLabs.com be effective against bioweapon Astellas Pharma US Inc. Researches metabolic parameters of attacks and other bacterial www.astellas.us diabetes, obesity and aging. Offers infections. Researches and develops pharmaceuticals nutritional supplements for the treatment for select theraputic areas, including of these conditions. urology, immunology, dermatology, cardiology and infectious diseases.

52 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 53 Atrius Bioscience Avidity LLC BioNovo BioSyntrx Inc. Bolder BioPATH Inc. Brotica Boulder Aurora Aurora Colorado Springs Boulder Bellvue (303) 531-5955 www.avidity.com www.bionovo.com www.biosyntrx.com www.bolderbiopath.com www.interval33.com Researches the use of systems Licenses the patented biotin-accepting Discovers and develops drugs for Develops nutraceuticals to address the Contract pathology and pharmacology Produces Interval33, a termite attractant biology, enabled by metabolomics and peptides (AviTag) technology which women’s health, including menopause, micronutrient needs of the dry eye, research company that specializes in which works by producing the precise 3-dimensional tissue biology to support exploits the tight interaction of avidin or osteoporosis and cancer. cataract, macular degeneration, glaucoma inflammatory disease models with level of CO2 that has been shown to discovery efforts. The biomarker streptavidin with biotin for immobilizing, and diabetic retinopathy patient. emphasis on models of arthritis. attract termites and is all natural and discovery platform is directed toward purifying and visualizing proteins. BioResponse LLC animal safe. development of small molecule treatment Boulder Biotest Laboratories LLC Bolder BioTechnology Inc. modalities and metabolic therapies, as BaroFold Inc. www.bioresponse.com Colorado Springs Boulder CaP Biotechnology well as predictive diagnostics, applied to Boulder Researches, develops and commercializes www.biotest.net www.bolderbio.com Golden complex disease states. www.barofold.com dietary supplements and functional foods. Manufactures and distributes dietary Uses advanced protein engineering www.capbio.com Discovers, develops and commercializes supplements. technologies to create proprietary human Develops advanced calcium phosphate Aurogen protein biologics. The pipeline contains BioServe Space Technologies protein pharmaceuticals with enhanced materials and devices for biomedical and Fort Collins therapeutics with an immunology focus, Boulder Bioxel Pharma Inc. therapeutic properties. biotechnological applications. www.aurogen.com including Multiple Sclerosis, Rheumatoid www.colorado.edu/engineering/BioServe Lafayette Produces a pharmaceutical treatment Arthritis and Asthma. Researches space life science with a www.bioxelpharma.com Boulder Scientific Company Cargill Research for diabetic neuropathy, with a second wide range of biotechnology applications Manufactures and distributes taxane Mead Denver, Englewood, Fort Collins invention showing that neurotrophic involving animals, plants and pharmaceutical ingredients including www.bouldersci.com www.cargill.com hormones can act across the blood-brain microorganisms. paclitaxel, docetaxel, 9-DHB and 10-DAB, Provides organometallic compounds Develops, processes and markets science- barrier to treat various brain disorders. used in oncology for the treatment of cancer, to the pharmaceutical, polymer and based, health promoting ingredients for including breast, lung, ovarian, stomach, specialty chemical industries. food and dietary supplement industries prostate and head and neck cancers. worldwide.

CPC Provides Comprehensive Multi-Center Clinical Research Services

x Clinical Trial Design and Execution x Biostatistics and Data Management x Global Project Management x Site Monitoring x Medical Affairs SPEEDING TECHNOLOGIES TO THE GLOBAL MARKETPLACE x Management of: x Steering Committees “Colorado State University creates value for society by developing talent and technology through x Data and Safety Monitoring Boards scholarship. Through technology transfer and successful start-up companies, society realizes the x Clinical Endpoint Committees beneﬁts of this scholarship and innovation in the form of new products and services. As a 21st-century x Core Laboratory Services land–grant institution, Colorado State University invites industry partners to engage with us in local x ECG/TQT research and technology development to solve global problems.” We are an academic research x Treadmill – William H. Farland organization (ARO) dedicated to improving x Wound assessment Vice President for Research x www.vpr.colostate.edu health through clinical research and Recruitment Call Center integrating scientific evidence into x Scientific Writing

MicroRx and NeoTREX are divisions of CSU Ventures, Inc., a proud afﬁliate of Colorado State University. community prevention programs. Colorado Prevention Center CPC incorporates a unique quality 789 Sherman Street, Suite 200 intervention program into every trial, Denver, CO 80203 Global Health Solutions Advancing Cancer Treatment which minimizes endpoint variability. This 303-860-9900 www.microrx.org www.neotrex.org translates into definitive signals and www.cpcmed.org clearer results. For more information e-mail: [email protected]

54 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 55 Catalent Pharma Solutions Inc. Cell>Point ClinImmune Labs Dharmacon Inc. (A Thermo Fisher Evolutionary Genomics Genetic Technologies Limited Boulder Centennial Aurora Scientific company) Lafayette Fort Collins www.catalent.com www.cellpointweb.com www.clinimmune.com Lafayette www.evolgen.com www.gtg.com.au Designs, manufactures and distributes Develops novel radiopharmaceutical Provides clinical HLA typing and www.dharmacon.com Identifies genes with a high likelihood Specialized in licensing, genetic testing specialized medical products for fluid imaging agents, radiotherapeutic agents cross matching in support of kidney, Develops 2’-ACE RNA technology of commercial value for downstream and research programs around the world management of pleural effusion and and local regional radio/chemotherapeutic bone marrow, heart, lung and pancreas as the standard for RNA synthesis validation through their proprietary using “noncoding” DNA. ascites. drug delivery systems for the diagnosis, transplant programs. and to advance RNA oligo-dependent Adapted Traits platform. treatment and post therapy asessment of applications and technologies. Provides Gilead Colorado Inc. Caveo Therapeutics cancer, cardiovascular disease, infectious Colorado Genetics Inc. RNA oligos to the research community. Feiger Health Research Center Westminster Aurora disease and metabolic diseases. Loveland Lakewood www.gilead.com www.caveotherapeutics.com www.coloradogenetics.com DMI BioSciences Inc. www.feigerresearch.com Discovers, develops and commercializes Discovers and develops innovative Ceragenix Pharmaceuticals Provides livestock embryo-transfer Aurora Private research facility specifically medicines focusing on antivirals (HIV/ biopharmaceuticals to treat and cure Denver research, artificial insemination, embryo www.dmibio.com focused on clinical trials for medication AIDS and chronic hepatitis), cardiovascular hematologic conditions. Provides www.ceragenix.com collection, freezing and transfer and Discovers and develops therapeutic to treat depression. conditions (pulmonary arterial hypertension two research reagents, highly specific Engages in the discovery, development international import and export services. options to treat men’s health, and resistant hypertension) and respiratory monoclonal antibodies to the Mer and commercialization of a portfolio of ophthalmology and oncology with earlier- GEL Analytics LLC diseases (influenza and cystic fibrosis). receptor tyrosine kinase. innovative products for dermatology and Colorado Histo-Prep stage NCE programs in autoimmune, Golden infectious disease applications. Fort Collins cardiovascular and oncology. www.gel.com GlaxoSmithKline CBL BioPharma www.histoprep.com Offers expertise in the field of mass Denver Boulder Cévan International Inc. Produces high quality slides, clinical Efficas Inc. spectrometry and provides chemistry, www.gsk.com www.cblbiopharma.com Longmont chemistry and hematology data and Boulder radiochemistry, radiobioassay and Produces medicines that treat six major CBL Biopharma is engaged in the www.cevan.com fully integrated and detailed seamless www.efficas.com bioanalytical analysis. disease areas – asthma, virus control, discovery, development and supply Delivers vitamins, minerals and botanical pathology reports. Develops bioactive products that offer infections, mental health, diabetes and of starting materials, intermediates extracts as well as specialty nutriceutical natural relief from asthma and allergies in Gene Check Inc. digestive conditions as well as vaccines and active ingredients for peptide formulations and antioxidants. Colorado Serum Company both humans and animals. Greeley and new treatments for cancer. pharmaceuticals. Denver www.genecheck.com CHATA www.colorado-serum.com ELISA Tech Develops, produces and markets reagents Global Peptide Services LLC Cedus Fort Collins Supplies veterinary biologic vaccines, www.elisatech.com and kits for research and offers veterinary Fort Collins Fort Collins www.chatasolutions.com instruments, laboratory reagents and Provides immuno assay services and genotyping tests www.globalpeptide.com www.cedusinc.com Manufactures blended reagents, HPLC serums for the veterinary industry. goods to researchers including immuno for sheep. Offers peptides and polyclonal antibodies Develops technology for sterilizing mobile phases, standards, buffers and assays for the measurement of cytokines, to both academia and industry. companion animals with a single dissolution media. Cytomation GTX Inc. growth factors and lipid inflammatory Genesis Laboratories Inc. injection. Fort Collins mediators such as prostaglandins and Wellington GlobeImmune Inc. Cinpathogen Inc. www.cytomationgtx.com leukotrienes. www.genesislabs.com Louisville Celgene Boulder Develops a sensitive and rapid Provides services to clients in the www.globeimmune.com Boulder www.cinpathogen.com genotoxicity assay in mammalian cells Eurofins Medinet agrochemical and pharmaceutical Discovers, develops and manufactures www.celgene.com Brings together clinical operations, using flow cytometry. Aurora industries, rodenticide research and potent, targeted molecular immunotherapies Focuses on acquiring, developing and diagnostic laboratories and access to a www.eurofins-medinet.com development, as well as invasive species, called Tarmogens for the treatment of commercializing innovative products large tissue bank to support diagnosis Cytoskeleton Inc. Provides bioanalytical testing and support zoonotic disease and conservation cancer and infectious diseases. for the treatment of hematology and and conduct protocol-driven research on Denver services to the pharmaceutical, food, research. oncology patients in the United States, the etiology, pathogenesis and treatment www.cytoskeleton.com environmental and consumer products Greffex Inc. Europe and other international markets. of disease. Offers kits for drug screening, signal industries and to governments. GeneThera Inc. Denver transduction and cytoskeletal research Wheatridge www.greffex.com specializing in the production of purified www.genethera.net Develops and produces new therapeutics proteins and easy-to-use kits to study Develops and markets assay tests and for immune suppression in humans to biochemical and cellular processes. vaccines to radicate the threat to humans prevent transplant rejection, improve gene of diseases transmitted up the food chain therapy and develop novel approaches to by cattle, elk and deer. the treatment of autoimmune diseases.

56 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 57 Hauser Laboratories, Division of IHCtech LLC InB: Paxis Pharmaceuticals Inc. InViragen Inc. Kromatid Inc. MacLeod Pharmaceuticals Inc. Microbac Aurora Boulder Fort Collins Fort Collins Fort Collins Boulder www.ihctech.net www.paxispharma.com www.inviragen.com (505) 662-5626 www.macleodpharma.com www.hauserlabs.com Offers custom histopathology services, Manufactures and markets the generic Develops vaccines for emerging Develops a method and kit using Develops and manufactures anti-bacterial Provides research, development and antibodies, probes and biosensors tested in active pharmaceutical ingredient infectious diseases worldwide, including chromatid paints to improve detection pharmaceuticals for the veterinary testing to the pharmaceutical, natural tissue. Specializes in immunohistochemistry paclitaxel as well as other naturally dengue fever, west nile vius, plague, of chromosomal inversions. The industry. products, dietary supplement and medical and in situ hybridization. derived taxanes. smallpox and avian influenza. improvement is important to medical device industries. applications such as cancer and birth Mantic Biotech imuTek Laboratories Inc. Insmed Therapeutic Proteins Isogenis Inc. defects. Loveland HemoGenix Fort Collins Boulder Denver www.manticbiotech.com Colorado Springs www.imutek.com www.insmed.com www.isogenis.com LABS Inc. Develops proprietary technology and www.hemogenix.com Develops and markets bovine colostrums for Pursuing a dual path stratagy involving Develops therapies for organ transplantation Denver software to accurately represent and Private contract research service the nutrition and health products industry. entry into the follow on biologics arena and genetic disease with products based on www.labs-inc.org model protein conformations as discrete and assay development laboratory and advancing their proprietary protein the veto effect which occurs when specific Provides laboratory testing services structures. specializing in developing predictive in InB: Hauser Pharmaceuticals Services Inc. platform into niche markets with unmet T-cells programmed to destroy a transplant focused on donor eligibility vitro assay platforms for primary human Denver needs. are all permanently inhibited. determination and final product safety, Martek Biosciences Boulder and animal target cells and stem cell www.inbhauser.com infectious disease, microbiology, Corporation hemotoxicity testing. Provides research, process development, Institute for Therapeutic Biology Johnson & Johnson/Ortho Biotech histocompatibility and environmental Boulder analytical services, manufacturing, Denver Denver monitoring. www.martekbio.com Heska Corporation compliance services and consulting to www.therapeuticbiology.org www.jnj.com Develops, manufactures and sells Loveland produce compounds from natural raw Research organization studying the role Manufactures a broad selection of health Legacy BioDesign LLC products from microalgae. Products www.heska.com materials for the pharmaceutical, dietary of T-Cell maturation in immunology. care products, as well as a provider Loveland include nutritional supplements and GIB_Insmed_Small Space_V3:Layout 1 3/14/08 2:31 PM Page 1 Develops advanced diagnostics and supplement and fine chemical industries. of related services, for the consumer, www.legacybiodesign.com food ingredients which play a role in specialty products for veterinary practices pharmaceutical and medical devices and Conducts peptide and protein formulation promoting mental and cardiovascular that focus on companion animals. diagnostics markets. and assay development work for health. biopharma companies. The company also Hiberna Corporation COMBINING SCIENCE AND Keen Ingredients Inc. specializes in drug delivery and process MBC Pharma Inc. Boulder EXPERIENCE, ALL IN Louisville development of biotechnology-based Aurora www.hibernapharma.com www.keeningredients.com products. www.mbcpharma.com Researches life saving therapeutics from A DAY’S WORK. Develops process to de-bitter and Biopharmaceutical company focused natural models of extreme metabloic stabilize quinoa naturally. LifeVantage Corporation on discovering and developing drugs regulation. Greenwood Village for bone diseases such as cancer and Keeton Industries Inc. www.protandim.com osteoporosis. INSMED scientists, with experience working High Quality Research LLC Wellington Develops nutraceutical products on over 50 therapeutic proteins, are taking Fort Collins www.keetonaqua.com including Protandim®, a supplement that Mediral International Inc. the lead in meeting unmet medical needs. www.hqrllc.com Researches and develops biological water is formulated to fight free radical damage We develop therapies to treat orphan diseases Denver Provides contract research in a wide including Myotonic Muscular Dystrophy. We’re treatment, aeration, ozone aeration, solids on a cellular level. www.mediral.com range of in vivo studies utilizing several also looking to the future of biotechnology and removal, biofiltration and other new Develops, manufactures and sells different animal models. the future of medicine. Insmed is poised to be a technologies. Lohocla Research Corporation homeopathic pharmaceuticals. leader in follow-on biologics in the United States, Aurora Hospira an industry that will save both lives and money. Kimball Genetics Inc. www.lohocla.com Miragen Therapeutics Boulder Join us at: www.insmed.com Denver Develops diagnostics and therapeutics Boulder www.hospira.com www.kimballgenetics.com focused on pain, psychiatric and addictive www.miragentherapeutics.com Supplies injectably generic and specialty Genetic testing laboratory specializing disorders such as alcoholism, depression, Focuses on microRNA biology to pharmaceuticals. The Colorado site in DNA analysis for common genetic smoking cessation and chronic pain. discover innovative treatments for specializes in the supply of active disorders that are preventable or can be cardiovascular disease. pharmaceutical ingredients for both INSMED Incorporated treated. internal and external markets.

58 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 59 Molecular BioSciences Inc. Nanodisc Inc. Oberon Peak BioSciences Inc. Proteome Resources R&D BioProducts Boulder Boulder Idaho Springs Fort Collins Englewood Fort Collins www.molbio.com www.nanodiscinc.com www.oberonfmr.com www.peakbiosci.com www.proteomeresources.com www.rndbioproducts.com Manufactures products such as water Develops and commercializes nanodiscs Researches and develops the production Specializes in developing and Manufactures ubiquitin-proteasome Provides research-grade, patented soluble biotinylation reagents, vitamin that permit the functional solubilization of single cell protein (SCP) from un- commercializing nanoscale (ultra- enzymes and proteins and offers peptide products to investigators for derivatives, crosslinking reagents, of membrane-associated proteins utilized food processing by-product localized) radiotherapy products to treat antibodies, and custom protein and therapeutic research purposes. lipophilic probes, fluorophores, (MAPs) as both drug targets and as drugs streams. Supplier of high-quality SCP cancer. peptide services. radioiodination reagents and dendritic themselves. destined for use in animal feed diets. Regenerative Sciences Inc. cores for preparing oligomers. Pfizer Pharmaceutical Company Provident Pharmaceuticals LLC Broomfield Navigant Biotechnologies Inc. OSI Pharmaceuticals Centennial Colorado Springs www.regenexx.com Monsanto Company Lakewood Boulder www.pfizer.com www.providentpharma.com Advances stem cell therapies Englewood www.navigantbiotech.com www.osip.com Discovers, develops, manufactures and Provides product development, through development of www.monsanto.com Develops techniques to improve safety Develops and commercializes high- markets prescription medicines for manufacturing and packaging Regenexx™, an injection procedure Develops technology to produce healthier of the blood supply by reducing the quality and novel pharmaceutical humans and animals. and laboratory services for the to treat a wide variety of painful foods, better animal feeds and more pathogens found in donated blood. products for patients with cancer, pharmaceutical industry. conditions. fiber, while reducing agriculture’s impact diabetes and obesity. PhosphoSolutions on our environment. Product lines Novartis Pharmaceuticals Aurora Pulmonex Inc. Replidyne Inc. include seeds and traits and agricultural Corporation Oxonica Inc. www.phosphosolutions.com Boulder Louisville productivity. Littleton Silverthorne Designs and produces phosphoproteins www.pulmonexinc.com www.replidyne.com www.novartis.com www.oxonica.com solutions using phosphor-specific Developing a therapeutic product for Focuses on discovering, developing, MycoLogics Inc. Researches and develops products Developed the NANOPLEX™ biomarker antibodies. Phosphoproteins are thought tuberculosis. in-licensing and commercializing Aurora to protect and improve health and detection platform that enables detection to be critical elements in neurological innovative anti-infective products. www.mycologics.com well-being with core businesses in of multiple disease markers, providing diseases such as alzheimer’s and disease Pyxant Labs Inc. Specializes in the development of pharmaceuticals, vaccines, consumer clinical laboratory performance and real cancer. Colorado Springs Roche Colorado therapeutic and prophylactic vaccines health, generics, eye care and animal time information at the point of care. www.pyxant.com Boulder against fungal and parasitic pathogens. health. Pisces Molecular Specializes in GLP bioanalytical www.rochecolorado.com Pambec Laboratories Inc. Boulder chemistry development support for life Develops manufacturing processes Mycos Research LLC Novus Biologicals Inc. Loveland www.pisces-molecular.com sciences clients. for complex pharmaceutical Loveland Littleton [email protected] Applies molecular biology to problems in compounds in the Colorado www.mycosresearch.com www.novusbio.com Researches drug discoveries in the field the aquatic environment. QLT USA Inc. manufacturing facility, a resource Provides mycobacterial-derived Develops, tests and markets antibodies of AIDS. Fort Collins for small to large-scale peptide biochemicals to the research community, for research of human diseases such as PR Pharmaceuticals Inc. www.qltinc.com manufacturing. contract research, models for tuberculosis cancer, cardiovascular and neurological Paragon Analytics Fort Collins Discovers, develops, commercializes and research and other BSL3 organisms and disorders. Fort Collins www.prpharm.com manufactures innovative drug therapies Rocky Mountain Diagnostics Inc. novel monitoring or vaccine products in www.paragonlabs.com Develops, manufactures and to create products for ophthalmology and Colorado Springs the area of mycobacterial infection. Nutraceutix Inc. Environmental and radiochemistry testing commercializes bioactive compounds dermatology. www.rmdiagnostics.com Lafayette laboratory offering radiochemistry, mixed in long acting injectable formulations Provides immunodiagnostic assays N30 Pharmaceuticals LLC www.nutraceutix.net waste, explosives, organics, metals and to treat chronic diseases in animals Quark Pharmaceuticals Inc. and reagents for biogenic amines, Boulder Offers probiotic organisms (powders) general chemistry analyses. and humans such as diabetes and Boulder research reagents, a CLIA-certified www.n30pharma.com and finished probiotic supplements. hypertension. www.quarkpharma.com reference laboratory and contract A clinical stage biopharmaceutical Specializes in custom crafting dietary Peak Analytical Inc. Discovers and develops siRNA drug manufacturing services. company focused on modulating supplements with advanced delivery Golden Premier Laboratory LLC candidates for treating Age-related s-nitrosothiols to treat respiratory technologies. www.peaklab.net Boulder Macular Degeneration and prevention of diseases. Specializes in materials and chemical www.premierlab.com Acute Renal Failure. analysis. Performs a variety of molecular Contract research laboratory that offers and atomic level spectroscopic techniques both standardized and specialized to identify failures and defects. preclinical pharmacology, histology and pathology services.

60 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 61 Rocky Mountain Instrumental Sierra Neuropharmaceuticals Inc. TOLMAR Inc. Vitro Diagnostics Inc. YewSavin Inc. BioEnergy of Colorado LLC Laboratories Denver Fort Collins Aurora Fort Collins Denver, Commerce City Fort Collins www.sierraneuro.com www.tolmar.com www.vitrodiag.com www.ajorganica.com www.bioenergyofamerica.com www.rockylab.com Discovers, develops and commercializes Specializing in the development, Develops and commercializes products Develops chemical and biochemical Produces biofuel alternatives. Current Provides contract chromatographic therapeutic products for diseases of manufacturing and worldwide derived from human cell line research technologies. product line includes Biodiesel (Gold and and mass spectrometric analysis of the brain. Produces reformulated oral distribution of a wide variety of with a focus predominantly in stem cell Green™) and BioHeat. pharmaceuticals (both traditional medications to be delivered directly into pharmaceutical and OTC products. R&D related to diabetes. ZeoponiX Inc. drugs and biotechnology products, the fluid around the brian for treatment of Boulder BioFuel Energy Corporation such as proteins and peptides and epilepsy, schizophrenia, bipolar disorder, US Pharmacal Company Inc. Vitrolife Inc. www.zeoponix.com Denver oligonucleotides), veterinary and human anxiety disorders and major depression. Erie Englewood Develops NASA originated technology www.bfenergy.com endocrinology and forensic toxicology. www.uspharmacal.com www.vitrolife.com to produce a soil amendment/fertilizer Constructs large scale ethanol production STA Laboratories Researches, develops and sells Develops, manufactures and sells zeoponic material that utilizes nutrients facilities in cooperation with Cargill. Rocky Mountain Reagents Inc. Longmont topical pharmaceuticals for the senior products and systems for the preparation, more efficiently and reduces nutrient Englewood www.stalabs.com community. cultivation and storage of human cells, leaching into the environment. BioMass Energy Foundation www.rmreagents.com Agricultural product testing laboratory tissue and organs. Product areas include Golden Manufactures stains, culture media and that offers seed quality, genomics, plant Upsher-Smith fertility, transplantation and stem cell www.biomassenergyfoundation.org chemistry solutions for the medical health and diagnostic services and Denver cultivation. BIOFUELS AND RELATED COMPANIES Researches alternative fuels such as dried industry, as well as titration reagents, products. www.upsher-smith.com fruit pits, vegetable oil, wood, coffee indicators, acids, bases and a variety of Develops, manufactures and markets Warren Analytical Laboratories A1 Organics grounds and the methods to produce chemicals for industrial uses. Summit Plant Labs Inc. a vast range of prescription and over- Greeley www.a1organics.com biofuels. Fort Collins the-counter products for cardiology, www.warrenlab.com Composts and recycles organic by-products Sandoz www.plantlabs.com dermatology, women’s health and other Specializes in food microbiology, from various waste: yard trimmings, wood, Blue Sun Biodiesel Broomfield Applies laboratory plant cloning and areas. molecular biology, food chemistry, biocides, agricultural by-products, manure, Westminster www.us.sandoz.com greenhouse technologies to produce residue chemistry and nutritional brewery by-products, construction debris www.gobluesun.com Focuses on pharmaceuticals, consumer planting stocks for breeders, greenhouses Ventria Bioscience labeling. and food residuals. Distributes premium agricultural and health, generics, eye care and animal and field crop producers. Fort Collins renewable fuel products. Blue Sun health. Therapeutic categories www.ventria.com Wildlife Pharmaceuticals Inc. Aerophase Fusion™ alternative diesel fuel is inlcude anti-infectives, anti-arthritics, Taiga Biotechnologies Inc. Develops a protein expression technology Fort Collins Longmont available at numerous retail pumps cardiovasculars, gastrointestinal agents Aurora platform called ExpressTec with a www.wildpharm.com www.aerophase.com throughout Colorado, Wyoming, New and psychotherapeutics. www.taigabiotech.com product pipeline in human nutrition and Providing pharmaceuticals for the safe Develops an efficient extraction system Mexico, Nebraska, Utah, and Idaho. Develops cellular, biologic and small therapeutics. and humane care of non-domestic and for biodiesel. Sciona Inc. molecule approaches to treat hemato- exotic wildlife species. Center for Biorefining and Boulder logical diseases, including cancers, Ventrus Biosciences Inc. Agro Management Group Inc. Biofuels (C2B2) www.mycellf.com immunodeficiencies and autoimmune Greenwood Village Windom Peak Pharmaceuticals Colorado Springs CU, CSU, Mines, NREL Applies evidence-based genetic conditions. www.ventrusbio.com Boulder www.agromgt.com www.c2b2web.org information to develop personalized A specialty pharmaceutical www.windompeak.com Researches, develops and markets A cooperative research and educational products that help individuals achieve Taligen Therapeutics Inc. company focused on the late-stage Develops novel antibiotics to treat vegetable-based motor oil for use in center devoted to the conversion of their health goals. Aurora development and commercialization of infectious diseases. 4-cycle engines. biomass to fuels and other products. www.taligentherapeutics.com gastroenterology products. Sentry Biosciences Focuses on the treatment of serious Wyeth BBI International Community Power Corporation Greenwood Village inflammatory diseases including asthma, Verdant BioSciences Corporation Lakewood Salida Littleton (720) 488-4725 macular degeneration and immune Denver www.wyeth.com www.bbibiofuels.com www.gocpc.com Discovers and develops compounds that kidney disease. www.verdantbio.com Offers products in the areas of Offers consulting services, including Develops, commercializes and markets regulate the process of programmed cell Develops plant biochemical regulators women’s health care, neuroscience, feasibility studies, market analyses, site modular biopower systems to meet the death (apoptosis). that provide superior plant performance musculoskeletal disorders, cardiovascular and resource assessments, economic needs of distributed energy consumers in and unlock the productive power of plants therapy, vaccines and infectious disease, impact studies, business plans, industry both developing and developed countries. in markets from floriculture to industrial hemophilia, immunology and oncology. benchmarking and industry surveys to the agriculture. biofuels sector.

62 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 63 Copernican Energy Inc. Intermountain CHP Center PureVision Technology Inc. Bonfils Blood Center Colorado School of Mines (CSM) Research and Education Institutions Boulder Boulder Fort Lupton Denver Metro Golden www.copernicanenergy.com www.intermountainCHP.org www.purevisiontechnology.com www.bonfils.org www.mines.edu Produces fuels and chemicals from Provides neutral, objective and Develops a carbon-neutral biomass Aims Community College One of the nation’s leading A public research university renewable feedstocks through the unbiased expert opinions about fractionation technology that Greeley, Loveland, Fort Lupton community blood centers through internationally recognized for its application of solar-thermal energy. whether Combined Heat Power converts cellulosic biomass into www.aims.edu their commitment to quality service, leadership in engineering, applied (CHP) is cost-effective and sugars, energy and fiber that are bio- One of the largest and most innovation, research and technology. science and related disciplines, with Delta Dynamics LLC technically feasible. based raw materials to make many comprehensive two-year colleges They offer a full range of blood a special emphasis on the Earth and Denver industrial and consumer products. in Colorado. Since 1967 Aims products and services to health care its resources. These programs, with www.deltadynamicsenergy.com LUCA Technologies Inc. has established four campuses, partners including supplying rare strong interdisciplinary linkages Constructs and installs small-scale Golden Rentech Inc. constructed 18 buildings, expanded blood units or helping to determine across the campus, have led to biomass plants. www.lucatechnologies.com Denver curriculum to 2,000 day, evening the best cross-matched unit to the integration of bioscience and Researches the ability of naturally www.rentechinc.com and weekend courses and taught ensure the best possible patient biotechnology into educational Front Range Energy LLC occurring microorganisms to Develops technology and projects more than 300,000 students. outcomes. and scholarly activities. CSM has Windsor convert under-utilized domestic to convert biomass into ultra-clean created a Bioengineering and Life www.frontrangeenergy.com oil, organic-rich shale and coal fuels and chemicals. AMC Cancer Research Center Centers for Disease Control Science Program that draws upon Ethanol producer since 2006. Will resources to clean, renewable Denver and Prevention/Division of faculty and students from all of the process approximately 40 million energy. San Juan Bioenergy www.amc.org Vector-Borne Infectious Diseases academic units. gallons of ethanol and 396,000 tons Dove Creek AMC is a national, not-for-profit Fort Collins of wet distillers’ grain annually. Merrick & Company www.sanjuanbioenergy.com research institute dedicated to the www.cdc.gov/ncidod/dvbid Colorado State University (CSU) Aurora, Colorado Springs, Commerce Sells sunflower oil into food prevention and control of cancer The division of Vector-Borne Fort Collins, Pueblo Gevo Inc. City markets and biodiesel for fuel, also and other chronic diseases. AMC Infectious Diseases (DVBID) is www.colostate.edu Englewood www.merrick.com produces its own renewable heat is conducting innovative and part of the U.S. Centers for Disease As one of the nation’s leading www.gevo.com Provides engineering, construction by burning sunflower hulls and important research in the areas of Control and Prevention (CDC). research universities, Colorado Develops advanced biofuels such management and development glycerine. cancer causation and prevention, CDC is the lead federal agency State University is committed to as isobutanol, a butanol that will services for biomass conversion- behavioral research, nutrition, responsible for protecting the realizing its vision as a 21st century provide a sustainable path to the to-ethanol projects. Also provides Solix Biofuels clinical and community studies and health and safety of people at home land-grant university. CSU leads replacement of petrochemicals such consulting services to oil and Fort Collins health communication. and abroad. DVBID serves as a the world in such areas as infectious as gasoline, diesel and gas clients and locally regulated www.solixbiofuels.com national and international reference disease research, atmospheric jet fuel. utilities. Develops massively scaleable Biological Sciences Curriculum center for vector-borne viral and science and environmental science. photo-bioreactors for the production Study (BSCS) bacterial diseases, such as West Its faculty members are tackling Great Plains Oil LLC OPX Biotechnologies Inc. of biodiesel and other valuable bio- Colorado Springs Nile virus, Lyme disease, plague, such issues as the reemergence of Eads Boulder commodities from algae oil. www.bscs.org tularemia, yellow fever and dengue. tuberculosis, the brown cloud of www.greatplainsoil.net www.opxbiotechnologies.com A non-profit corporation that It coordinates national disease air pollution in Asian cities, severe Manufactures and distributes Uses a synthetic biology platform to Sterling Ethanol LLC endeavors to improve all students’ monitoring activities, conducts field weather forecasting, nutrition new vegetable oil-based products custom design the microbes used to Sterling understanding of science and and laboratory research, responds and wellness and bioterrorism. In processed from natural materials, make biofuels. www.sterlingethanol.com technology by developing to epidemic situations, develops addition to its excellent programs including sunflower oil, soybean oil Produces 42 million gallons of exemplary curricular materials, strategies for disease prevention in those areas, CSU offers among and canola oil. Power Ecalene Fuels Inc. ethanol annually. supporting their widespread and and control, provides diagnostic the very best professional programs Arvada effective use, providing professional reference and epidemiologic in the United States in areas like Great Western Ethanol www.powerecalene.com development and conducting consultation and conducts technical veterinary medicine, occupational Greeley Produces Ecalene™, an alternative research and evaluation studies. assistance and professional training therapy, journalism, agriculture www.greatwesternethanol.com fuel that can be produced from any activities. and construction management. Its Produces Ethanol/DDGS/CO2. material containing carbon and programs in the arts, humanities and hydrogen. social sciences are also outstanding.

64 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 65 Community College of Aurora (CCA) Institute for Therapeutic Biology National Renewable Energy Infrastructure (NBII). This is the first University of Denver (DU) Aurora Denver Laboratory (NREL) comprehensive electronic gateway Denver www.ccaurora.edu www.therapeuticbiology.org Golden dedicated exclusively to biological www.du.edu CCA provides lifelong educational A non-profit research institute www.NJlabs.org www.nrel.gov science data and information from sources DU strives to provide the most opportunities, prepares the current and for drug discovery in the field of The nation’s primary laboratory for throughout the world. modern educational and research future workforce and promotes excellence immunology. Becca Morgan, Study Coordinator renewable energy and energy efficiency facilities in the life sciences. Their 303.270.2543 / [email protected] in teaching, learning and service. CCA research and development (R&D). history spans the Denver Research offers a unique Biotechnology Technician Keystone Symposia on Molecular Business Development: 303.270.2450 NREL’s mission and strategy are focused HELP GROW COMPANIES Institute’s development of the first FROM UNIVERSITY RESEARCH Research and Development Certificate and Cellular Biology on advancing the U.S. Department of NASA life monitoring sensors, the designed to train highly skilled lab Silverthorne Energy’s and our nation’s energy goals. establishment of a state-of-the-art personnel for the biotech industry. www.keystonesymposia.org National Jewish Medical and NREL’s R&D areas of expertise are: forensics laboratory, to the 2003

NJC_ADx_DirAd.inddResearch 1 Center (NJC) 3/28/08 3:40:19 PM A non-profit organization that renewable electricity (solar, wind, biomass, acquisition of the Eleanor Roosevelt Denver The University of Colorado Technology Denver School of Science and serves as a catalyst for the geothermal), renewable fuels (biomass, Transfer Office is seeking Front Range Institute with pioneering efforts in Technology (DSST) advancement of biomedical and life www.njc.org hydrogen), integrated energy system businesses and professionals to volunteer as genomics and bioinformatics. In The number one respiratory hospital in advisors for new companies. Denver sciences by connecting scientists engineering and testing (buildings, electric 2004, the School of Engineering the U.S. is also one of the most influential Contact: 303-735-5518 www.scienceandtech.org within and across disciplines at systems and transportation infrastructures), Lindsay Polak [email protected] and Computer Science unveiled Is dedicated to providing a diverse conferences and workshops held at independent biomedical research centers in strategic development and analysis Colorado’s first undergraduate student body with an outstanding liberal venues that create an environment the world. More than 100 faculty members (economic, financial and market analysis, University of Colorado (CU) program in Bioinformatics and a arts high school education with a science conducive to information exchange, conduct basic, translational and clinical planning and portfolio prioritization). Boulder, Denver, Aurora, Colorado Springs master’s degree in Bioengineering. and technology focus. By creating a generation of new ideas and research in immunology, respiratory www.cu.edu The interdisciplinary mission of the medicine, allergy, cancer and cell and powerful learning community centered on acceleration of applications that Poudre Valley HeaLth System The University of Colorado System’s University enabled the Department molecular biology. NJC ranks among the core values and a shared commitment to benefit society. Loveland, Fort Collins 52,000 students and 28,000 faculty and staff of Biology to launch new emphases top ten percent of all institutions for NIH academic excellence, DSST will increase www.pvhs.org contribute to every facet of life in Colorado. in Bioengineering, Biophysics and the number of underrepresented students National Institute of Standards support and for the impact of its research Poudre Valley Health System operates The state’s economic vitality, educated Cognitive Neuroscience designed for (women, minorities and economically and Technology (NIST) papers in the fields of Molecular Biology, as a private, not-for-profit organization workforce, entrepreneurial climate, cultural molecular biology majors. In addition disadvantaged) who attain college science Boulder Genetics and Biology and Biochemistry. providing a regional network of health capital, health care delivery and scientific to strong and quality curricula, and liberal arts degrees. www.nist.gov NJC manages a technology portfolio of care services for the people of northern explorations all rely on the driving force bioengineering and life sciences at NIST is a non-regulatory federal more than 100 investors. Colorado, western Nebraska and southern of a vigorous state university. By working DU carry multimillion-dollar-a-year Front Range Community College agency that operates eight Wyoming. The system is comprised of with other CU academic and research research studies in the creation of Fort Collins, Longmont and Westminster different science and advanced Advanced Diagnostic Laboratories the Poudre Valley Hospital, the Medical units, as well as local, state and federal new knowledge and leading edge www.frontrange.edu technology research divisions in (Adx) at National Jewish Medical and Center of the Rockies, as well as several funding agencies, commercial business and biotechnologies to improve quality of Front Range Community College, Colorado. NIST’s list of research Research Center community clinics that provide primary non-profit organizations, CU is creating a life for a worldwide community. Colorado’s largest community college, accomplishments includes a Denver and specialized medical services. Poudre collaborative synergy in important areas provides instruction in both general NIST senior scientist winning the www.njlabs.org Valley Hospital was named one of the that will better the wellness of society. The University of Northern Adx offers cost-effective and timely pre- education and occupational areas, Nobel Prize in 2001 for creating nation’s top 100 hospitals for the fifth year, CU Institute of Bioenergetics, the Colorado Colorado (UNC) clinical, clinical and non-clinical trials and which may lead to a certificate, an the world’s first “Bose-Einstein has been considered a Magnet Nursing Initiative in Molecular Biotechnology, the Greeley helps customers select, customize, perform, associate degree or transfer to a four- condensate.” In 2003 another Practice since 2000 and has been presented Center for Computational Biology and the www.unco.edu year institution. The college also NIST scientist won a MacArthur interpret and report clinical tests. Their with the American Nurses Association’s Center for Pharmaceutical Biotechnology University of Northern Colorado is a provides college preparatory education, Fellowship for discovering a new reference laboratory provides solutions for highest award for sustained overall attract intellectual strength to Colorado, multipurpose institution with a wide non-credit instruction for personal and quantum gas and was named by the rapid development of custom assays, excellence in nursing quality. provide new educational opportunities and range of graduate and undergraduate professional development and workplace Science magazine as one of the top consultation, clinical strategy assessments inspire innovative health care advances. programs. The university’s mission is and innovation within the areas of the skill development. With campuses 10 scientific advances of the year. United States Geological Survey (USGS) Research and teaching hospitals to prepare individuals for advanced National Jewish expertise. ADx operates located in Fort Collins, Longmont and Center for Biological Informatics affiliated with the University of Colorado study, professional careers and under GLP guidelines when applicable and Westminster, the college is proud of its Denver include: The University of Colorado positions of leadership. the laboratories are fully accredited by the many partnerships to provide quality www.biology.usgs.gov/cbi Hospital, The Children’s Hospital, National programs that are responsive to the needs College of American Pathologists (CAP) The Center for Biological Informatics, Jewish Medical and Research Center, of its local communities. and the Clinical Laboratory Improvement at the Denver Federal Center, operates Denver Health and the VA Medical Center. Act (CLIA), as well as others. the national Biological Information

66 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 67 Service Providers The Children’s Hospital Foundation University of Colorado Foundations www.imaginethemiracles.com Foundation The Children’s Hospital Foundation is the Boulder Colorado State University fundraising arm for TCH programs and www.cufund.org Architects Construction & Facilities LABORATORY FURNITURE & FUME HOODS Research Foundation (CSURF) operations. Since 1978, the Foundation The University of Colorado Foundation LABORATORY & MEDICAL EQUIPMMENT Fort Collins has raised more than $200 million for is a privately governed non-profit H+L Architecture Air Liquide www.csurf.org the hospital and today, is in the middle corporation whose mission is to support www.hlarch.com www.airliquide.com CSURF is a private, not-for-profit of a fundraising campaign to financially the University of Colorado. As a valued Leo A Daly Apecs Inc. Val Ross Colorado Corporation established (in support the building of a new hospital and trusted partner, the University of Laboratory Furniture Specialist www.leoadaly.com www.apecs.net 303.952.5258 1941) to aid and assist the University at Fitzsimons, as well as Children’s Colorado Foundation generates the For over forty years, ISEC has served the Colorado campuses (Colorado State University programs and services. private support needed in perpetuity for RNL Design Capstone region as the largest dealer of Thermo Scientific and recently Colorado State University CU to achieve international preeminence Hamilton Laboratory Furniture and Fume Hoods www.rnldesign.com www.capstone.com Pueblo) governed by the Board of Poudre Valley Health System Foundation as a public research university. Our www.isecinc.com

Governors of the Colorado State Loveland, Fort Collins donors enable CU to reach its full Root Rosenman Architects Cator, Ruma & Associates ISEC Laboratory Services University System in their research and www.foundation.pvhs.org potential to transform lives world-wide www.rootrosenman.com www.catorruma.com ISEC COBioScienDirectoryAd-June08.indd 1 3/10/2008 12:11:52 PM www.isecinc.com educational efforts. Functions include The Poudre Valley Health System through education, research, clinical care patent and licensing management; Foundation philanthropically supports and and community service. The Abo Group CH2M Hill (formerly VECO) Martin / Martin Consulting equipment leasing and municipal promotes the health interests of Poudre www.theabogroup.com www.ch2m.com Engineers lease administration; financing of Valley Hospital, the Medical Center of www.martinmartin.com equipment, real estate and buildings the Rockies and the community by raising The FWA Group Architects CRB Engineers & Builders www.fwagroup.com www.crbusa.com through mortgage debt obligation(s); and distributing funds for programs that Shaffer Baucom Engineering & and land acquisition, development and target prevention, education, research, Consulting First Century Development management. health promotion, wellness and disease www.sbengr.com [email protected] management. The Neenan Company George Butler Associates Inc. (GBA) www.neenan.com www.gbutler.com

REGULATORY, CLINICAL, VALIDATION AND REIMBURSEMENT CONSULTING LEO A DALY is pleased to announce the acquisition of CBR International www.cbrintl.com CBSA is proud to represent Colorado’s vibrant medical device, biotechnology, Maynard/David pharmaceutical, and agricultural biotechnology sectors. The 400 companies Partnership, Global Quality Alliance LLC Colorado www.gqaconsulting.com in the State range from large manufacturers to early stage R&D companies. Prominent research institutions anchor industry clusters in Colorado Springs, This expands Knowledge-Forge our resources Denver, Aurora, Boulder, and Fort Collins. in Denver as a www.knowledge-forge.com local/national Science + MARK Dott LLC Technology www.markdottllc.com practice.practice For more information go to MPI Research Soon relocating to www.mpiresearch.com www.CoBioScience.com 2000 S. Colorado Blvd. Denver, CO 303.919.9321 Intermountain Healthcare Evironmental Resource Associates NextGen Pharma Technologies Salt Lake City, UT Arvada, CO www.leoadaly.com Richer Images LaCasse Photography www.nextgenpharma.com PLANNING  ARCHITECTURE  ENGINEERING  INTERIORS

68 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 69 Peak to Peak Pharmaceutical Facility Planning Arts Inc. Canadian Consulate GENERAL-DENVER Ernst & Young UMB Bank Associates www.planningartsinc.com www.international.gc.ca www.ey.com www.umb.com Legal Services [email protected] GBSM Jefferson Economic Council Fritsche Capital Group Inc. UV Partners Cooley Godward Kronish Pharmatech www.gbsm.com www.jeffco.org www.fcgcapital.com www.uven.com www.cooley.com www.pharmatech.com Grow LLC Longmont Area Economic Council GCG Financial Dorsey & Whitney Reglera Corporation www.growllc.com www.longmont.org www.gcgonline.com Hotels www.dorsey.com www.reglera.com High Quality Research LLC Metro Denver Economic IronStone Bank Faegre & Benson www.hqrllc.com Development Corporation www.ironstonebank.com Embassy Suites Hotel Denver-Aurora www.faegre.com www.metrodenver.org www.embassysuites.com Marty Goldberg Consulting LLC MEDdevice Acquisition Fairfield and Woods [email protected] Northern Colorado Economic Corporation Timbers, The (A Residence Hotel) www.fwlaw.com SUPPORTING THE GROWTH OF YOUR COMPANY Development Corporation www.mdacllc.com www.timbersdenver.com WITH A FULL SPECTRUM OF REGULATORY AFFAIRS AND QUALITY ASSURANCE SOLUTIONS Morningstar Consulting LLC www.ncedc.com Fulbright & Jaworski L.L.P [email protected] Merrill Lynch - www.fulbright.com 4840 Pearl East Circle, Suite 201E Northern Ireland Technology and Individual Office Incubators Boulder, Colorado 80301 Phone: 303.225.0980 Orra Group Development Center- Denver [email protected] Hamilton, DeSanctis & Cha LLP Fax: 303.225.0984 www.orragroup.com www.investni.com/international www.reguluspharma.com www.hdciplaw.com Morgenthaler Ventures Boulder Innovation Center Scientific Due Diligence South Metro Denver Chamber of www.morgenthaler.com www.boulderinnovationcenter.com Hensley, Kim & Holzer LLC Regulus Pharmaceutical www.scientificdd.com Commerce www.hkh-law.com Consulting www.bestchamber.com Premier Capital Alternatives Fitzsimons BioBusiness Partners www.reguluspharma.com Strategic Science www.premiercapitalalternatives.com www.fitzbiobusinesspartners.com Hogan & Hartson [email protected] The Greater Colorado Springs www.hhlaw.com Reimbursement Principles Economic Development Corporation Quest Capital Partners www.reimbursementprinciples.com Tech BizSolutions Inc. www.csedc.org www.quest-intl.com Insurance and Human Resource Holland & Hart www.techbizsolutions.us Administration www.hollandhart.com RMC Pharmaceutical Solutions Sequel Venture Partners www.rmcpharma.com Finance and Investment/ www.sequelvc.com J. Dennis Bruner, Ph.D, P.E. Inc. Economic Development Financial Services Chubb Group of Insurance www.jurispro.com/DennisBruner Silicon Valley Bank Companies www.svb.com www.chubb.com/businesses/cci/ Marsh Fischmann & Breyfogle LLP Other Business Consulting Adams County Economic Aweida Capital Management chubb1741.html www.mfblaw.com Development www.aweida.com Tango BioMedical Communication & Consult- www.adamscountyed.com www.coloradofund1.com CoBiz Insurance Inc. Sheridan Ross PC ing Berkshire Advisor Resource www.cobizins.com www.sheridanross.com [email protected] Arvada Economic Development www.berkadvisor.com The Hartford Association www.thehartford.com LOCKTON COMPANIES llc Snell & Wilmer Biotech Clarity Consulting LLC www.aeda.biz Boulder Ventures www.lockton.com www.swlaw.com www.biotechclarityconsulting.com www.boulderventures.com Tobin Ruparel Kenczak & Aurora Economic Development Mundell PC Oasis Outsourcing Sparks Willson Borges Brandt & Boston Strategic Partners Inc Council Citywide Banks www.trkm.com www.oasisadvantage.com Johnson PC www.bostonsp.com www.auroraedc.com www.citywidebanks.com www.sparkswillson.com Trinity Capital Services Six-Geving Insurance Inc. Conduit Group LLC Boulder Economic Council Colorado Capital Bank www.tricapllc.com www.six-geving.com Swanson & Bratschun www.conduitgroup.net www.boulderbusiness.org www.coloradocapitalbank.com www.sbiplaw.com Trinet CT Associates Broomfield Economic Commerce Bank www.trinet.com The McGaw Law Firm P.A. [email protected] Development Corp www.commercebank.com/colorado www.mcgawlaw.com www.broomfieldedc.com

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72 BIOSCIENCE COLORADO BIOSCIENCE COLORADO 73 THE FUTURE OF BIOSCIENCE

We asked executives to describe the future of bioscience. Here’s what they said:

What will be the coolest bioscience Which bioscience breakthrough will “Access to personalized medicinal therapies for a wide array health conditions,” job titles in five years? impact our lives most dramatically — DON FITZGERALD The service, quality and commitment “Personalized Medicines Manager / in the next decade? PRESIDENT Diagnostics and Therapeutics ROCHE COLORADO you know with a new name... Integration Manager,” “Transitioning to a bio-based economy. … We need to transition to an economy “RNAi technology — very simply the — DON FITZGERALD ability to turn on and turn off genes,” PRESIDENT that is based on plants, the sun — BILL BARKLEY ROCHE COLORADO and the wind,” CHIEF INTELLECTUAL PROPERTY OFFICER For years you’ve known Gambro BCT as the company that — ED LEHRBURGER “Chief Strategy Officer. That is the key CO-FOUNDER, PRESIDENT AND MARTEK BIOSCIENCES BOULDER has delivered world-class innovation, quality and service CEO OF PUREVISION TECHNOLOGY ® in this space — knowing how to set up “All the information from the genome,” through products such as the Trima Accel Collection System your strategy to take advantage of all of ® these issues,” “Laparoscopic and robotic surgery. — JOE COX and the Vista Information System. PRESIDENT — RYAN GILL, MANAGING DIRECTOR Heart surgery has always been open BOLDER BIOTECHNOLOGY COLORADO CENTER FOR BIOREFINING AND chest. I think surgery will be accelerated We are changing our name but not changing how we do BIOFUELS (C2B2) with actuators (the fingers on robots) business. The same values. The same strengths that have and imaging (miniature cameras) so you “Cellular energy generation. Some day can do surgery with a closed chest,” we should be able to capture energy from made us the global market leader. CaridianBCT, our new “Director of Discovery or Chief of motion and use it to power our homes,” Innovation,” -- IVAN VESELY — LEE TAYLOR name, reﬂects the care, quality, and service that we — BILL BARKLEY, CHIEF INTELLECTUAL FOUNDER AND CHIEF SCIENCE OFFICER CHIEF EXECUTIVE OFFICER deliver to customers, donors, and patients, as PROPERTY OFFICER, VALVEXCHANGE THERATOGS MARTEK BIOSCIENCES BOULDER well as our global focus and innovative approach “Profiling the human genome,” — KIRK CHRISTOFFERSEN “Molecular diagnostics. A much more to meeting customer needs. “Personal Roboticist,” detailed understanding of (disease) — LEE TAYLOR SENIOR DIRECTOR CORPORATE DEVELOPMENT GLOBEIMMUNE detection and the personalized admin- www.caridianbct.com CHIEF EXECUTIVE OFFICER istration of therapies will see a huge THERATOGS “A better means of arresting diabetes,” advance. One size doesn’t fit all, and it — JOSÉ H. BEDOYA will make medicine much more specific,” PRESIDENT AND CHIEF EXECUTIVE OFFICER DAVID BRUNEL OTOLOGICS CHIEF EXECUTIVE OFFICER BIODESIX

“ Both internally and externally, CaridianBCT presents and represents a level of trust that everyone understands, appreciates and expects. This makes us a partner in every exchange that all of the employees have throughout their lives.”

Project and Systems Leader Lakewood, Colorado USA

74 BIOSCIENCE COLORADO

timad.indd 1 5/13/08 3:29:49 PM 1-31-08_COBios_8.25x10.875_c_OL.1 1 1/30/08 1:03:29 PM