Bridging the Gap: from Discovery to Commercialization

Bioscience Discovery Visualizing Evaluation the Gap Grant Program page 6 page 24

Colorado by Directory the Numbers: of Bioscience 2011 update Companies and page 11 Resources page 42 Fitzsimons Life Science District a great place to raise an idea Located in Aurora, Colorado, it’s one of the largest bioscience developments in the country, a place where there’s plenty of room to grow an idea from discovery to market viability. Whether you start in the bioscience incubator or move into a state-of-the art lab facility, everything you need is close at hand. A cluster of talent and resources is available to you, including direct access to the more than 80 core laboratories at the University of Colorado Anschutz Medical Campus – all just steps away. Features throughout the district, such as parks and conference facilities, are designed to inspire collaboration. And a nearby mix of shops, restaurants and homes let your people thrive right along with your ideas.

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Welcome to the Colorado BioScience Association’s seventh edition of Bioscience Colorado, the state’s only in depth guide 22 and directory to the bioscience industry. Webb-Waring Biomedical This publication is an integral part of the Research Program: Association’s mission to support the regional Boettcher Investigators bioscience community through advocacy, resources and advancement of opportunities for collaboration. 24 With a printed circulation of 6,000 and Bioscience Discovery over 10,000 on-line impressions, this publica- Evaluation Grant tion is one of our industry’s greatest voices Bridging the Gap Program locally, nationally and internationally. This from discovery to year’s issue of Bioscience Colorado takes a commercialization closer look at the process from discovery to commercialization. As we explore each step 33 of a company’s lifecycle it is clear that Colo- 6 Colorado’s Clinical rado has the drive and dedication to succeed! Visualizing the Gap Trial Landscape

Holli Baumunk 8 36 Discovery to Mile High Development: Manufacturing President and CEO The Story of Colorado BioScience Association Technology Transfer 39 Produced by: Changing the Lives of 11 Patients for the Better: Colorado by the The True Measure of Colorado BioScience Association Numbers: Success for Colorado’s 216 16th Street, Suite 850 2011 update Bioscience Industry Denver, CO 80202 www.CoBioScience.com (303) 592-4073 16 42 Weaving a Web of Directory of Bioscience Published by: Support Companies and Colorado BioScience Association and and Guidance Resources Colorado Office of Economic Development and International Trade 18 When the Going Gets Tough, the Tough Get Creative Financing

BIOSCIENCE COLORADO 2010/2011 5 Visualizing the Gap

Discovery Valley of Death Preclinical Development FDA Clinical Trials FDA Approval (CO Sherpas) Review

Average 6.5 years 30 days Average Average Average Average Approval 1.5 years 2 years 3.5 years 1.2 years

Tech Transfer Business Development Assets Synthesize Chemical Compound IND Phase I Phase II Phase III FDA evaluates submission Office disclosures • CID4 510k • FBBp Determine Formulation, Develop PMA 20-80 100-300 1000-3000 Finalize manufacturing and Apply for Patent • Larimer Bioscience Cluster Delivery Technology healthy patient patient marketing issues • CBSA volunteers volunteers volunteers • Rocky Mountain Innosphere Conduct Preclinical FDA monitors Laboratory/Animal Studies Conduct Evaluate, Confirm post-submission development Research & University Assets Pharmacology FDA safety efficacy, efficacy, • CIMB Pharmacokinetics evaluates studies Pharmaco- pharmaco- • C2D2 economics, economics, • Advanced Diagnostics Labs - Nat’l Jewish Device Prototyping Biotech Conduct quality of quality of • Biochem Genetics Lab Dept Pediatrics, UC Denver Device Quality Systems Pharma formulation, life life • Ctr for Genetics & Therapeutics Lab, Nat’l Jewish Device Manufacturing Device dosage, • CO Genetics Lab Dept Pathology, UC Denver Diagnostic tolerance Assess side Monitor • DNA Diagnostic Lab UC Denver studies effects adverse • Genomics Proteomics Core Rocky Mtn Reg reactions Center of Excellence from long • High Throughput Sequencing Core Consortium term use for Comparative Genomics • Morphology and Phenotyping Core • Gates Regenerative Medicine • Mycobacteria Research Labs CSU • Network of Translational Technologies, CO Clinical Trials & Translational Svc Inst. IND/PMA NDA NDA • The Carl and Hazel Felt Lab for Pulmonary Filed Filed Approval Research National Jewish

Financing Qualifying Therapeutic Discovery Projects, Boetcher Webb-Warning Biomedical Grants & Government Grants Bioscience Discovery Evaluation Grant Program Venture Capital M&A and IPO

Biotech 10,000 Compounds 1,000 Compounds 5 Compounds enter trials 1 Compound approved Discovery

Biotech/Pharma Average Discovery to Commercialization Cost $800 million to $1 billion 10+ years Time/ Cost to Market Device/Diagnostic Average Discovery to Commercialization Cost $5 million to $100 million 5+ years

Colorado’s Royal Gorge Bridge, the world’s highest suspension bridge

6 2010/2011 BIOSCIENCE COLORADO Visualizing the Gap

Discovery Valley of Death Preclinical Development FDA Clinical Trials FDA Approval (CO Sherpas) Review

Average 6.5 years 30 days Average Average Average Average Approval 1.5 years 2 years 3.5 years 1.2 years

Financing Qualifying Therapeutic Discovery Projects, Boetcher Webb-Warning Biomedical Grants & Government Grants Bioscience Discovery Evaluation Grant Program Venture Capital M&A and IPO

Biotech 10,000 Compounds 1,000 Compounds 5 Compounds enter trials 1 Compound approved Discovery

BIOSCIENCE COLORADO 2010/2011 7 Discovery Valley of Death Preclinical FDA Review Clinical Trials FDA Approval Market Discovery to Development: The Story of Technology Transfer

By Andrea Pawliczek

he link between the research going on inside university walls and the development conducted by the entrepreneurial Colorado Technology Transfer Offices community may seem to be a natural • Colorado School of Mines Technology Transfer Office one,T especially in the bioscience arena. Uni- versity investigators engage in leading-edge • Colorado State University Ventures (CSUV) & The Colorado State research while entrepreneurs need innovative University Research Foundation (CSURF) ideas to create products that solve the most • National Jewish Technology Transfer Office challenging medical problems and promise to provide value in the marketplace. Although • University of Colorado Technology Transfer Office the connection may seem natural, the transfer • The University of Colorado-Boulder’s Colorado Initiative in Molecular of technology from university research to the Biotechnology commercial marketplace logistically represents a far from trivial challenge. • University of Denver Technology Transfer Office Prior to 1980, the government held rights to inventions generated from government- sponsored research including National University of Colorado (CU), calls strong technologies from both the Colorado School Institute of Health (NIH) grants. Although science a “necessary but not sufficient of Mines (CSM) and CU. Most recently, the the government held about 28,000 patents condition” to technology commercialization. BIC has supported a medical device with a at this time, only about five percent were According to Allen, “research funded by compound that can be used to create artificial licensed to industry. This woeful record of the NIH does a great job of pushing the bone developed at CSM. commercialization led to the 1980 Bayh- envelope of scientific knowledge.” But it Once the desired path is identified, the Dole Act, which passed the responsibility to is far from a straight-line path from this key roadblock is often funding. Bioscience commercialize inventions to the universities research to the marketplace. Among the many companies face the dreaded “valley of death” and teaching hospitals where the research challenges, researchers must zero in on the — a point where research may be beyond the was conducted. This led to the formation of most promising commercialization options fundamental science funded by the NIH but Technology Transfer Offices (TTOs) within and consider the different paths toward is not yet ready for traditional investment these institutions. commercialization, including licensing the from venture capitalists. Universities around The original mission of TTOs was technology to an existing company, conducting the state have developed unique approaches relatively simple — help research institutions further research to put the idea in a more to helping companies cross this valley both get patents based on researchers’ work, then market-ready position, or forming a new through direct funding and coordination of license those patents to companies for a fee. startup company. The staff of the TTO serves a funding sources to make sure companies are This mission has broadened substantially key role in helping researchers evaluate these in the best position to gain access to other over time with TTOs helping faculties address alternatives. funds. the challenges of an increasingly complex Other organizations sometimes partner The CU TTO offers Proof of Concept marketplace. with TTOs to support evaluation and (PoC) grants and investments that provide David Allen, Ph.D., Associate Vice commercialization. The Boulder Innovation $10,000 to $200,000 to advance research President for Technology Transfer at the Center (BIC), for example, supports down the road to commercialization. A

8 2011/2012 BIOSCIENCE COLORADO success story from this program is Taligen health measures, the researchers realized helped us connect with the funding options Therapeutics. The technology behind Taligen that the synthetic peptide strategy that available,” Holmes says. was developed by researchers at CU Denver they had developed might also be effective PeptiVir was one of the first two and National Jewish Health. The company against a variety of other viruses, including companies selected to participate in the received the CU TTO’s inaugural Proof of influenza. Importantly, their research Colorado Institute for Drug, Device, Concept investment in 2004 which provided targeted a highly conserved region of the and Diagnostic Development (CID4), a the leverage to secure additional commercial flu’s HA glycoprotein, offering the potential program that supports emerging life-science financing. Taligen was acquired by Alexion for a universal flu vaccine different from companies. The company also received for $111 million (upfront cash payment of current vaccines, which are only able to additional funds from Colorado’s Bioscience $111 million additional contingent payments target a few selected strains and must be Discovery Evaluation Grant Program earned upon reaching various clinical efficacy reformulated each year as viral mutants (BDEGP) to target another important and product approval milestones) in January replace previously circulating virus strains. respiratory virus. Holmes views the support 2011. The duo, however, did not have NIH from the TTO and CID4 as invaluable More recent beneficiaries of this funding to pursue this influenza research. in getting the research to this point. “As program, include Dr. Kathryn Holmes Through a grant from the CU TTO PoC biomedical scientists, we always dream and Dr. Robert Hodges, professors at program, they were able to conduct pilot of creating something useful for human the CU School of Medicine. Holmes and experiments that proved their protein strategy health, but we are just not taught much about Hodges used NIH funding to “identify a was effective against influenza virus. After commercialization,” she says. “CID4 and good strategy to inhibit the entry of the this success, the research was spun out into a the TTO help us and others to bridge the coronavirus, which causes SARS,” says startup company, PeptiVir. Yet the company gap from discovery to development of new Holmes. After the outbreak of SARS was needed additional funds at this point, and therapies.” controlled by coordinated global public the TTO “made sure we were aware of and Colorado State University (CSU)

BIOSCIENCE COLORADO 2011/2012 9 has developed another unique approach worked with the Superclusters include Solix is headquartered at the Research Innovation in Superclusters, which are designed to Biofuels and Advanced Microlabs. Solix Center, a facility on the CSU campus speed research to the market. With three Biofuels is working on a scalable method to designed to promote collaboration between Superclusters, CSU has in-house business cultivate oil-rich microalgae for a variety of the university and private sector. advisers who provide advice that aids biofuels and chemical intermediaries. Early Allen of CU notes that one of the most technology development across a variety of in its history, the company partnered with substantial influences TTOs can have is stages. Two Superclusters fall squarely in researchers at CSU to identify and optimize creating serial inventors. Once a scientist the bioscience arena — MicroRx, focused algae strains to maximize oil production. has seen the process of commercialization on infectious disease, and NeoTREX, The Company went on to raise a $16.8 through, they start actively assessing their focused on cancer. The third Supercluster, million Series A round in 2009 from several research to illuminate other potential Cenergy is focused in the clean energy prominent cleantech investors. With this commercial applications and evaluating the space. funding, the company has created a first-of- best experiments to validate each idea. The Supercluster experts “proactively its-kind demonstration facility in Durango, Dr. Linda Watkins, a Distinguished and reactively work with faculty to identify CO to optimize its technology on a large Professor in the Department of Psychology invention ‘moments’ and get the process scale. Solix remains a corporate partner of & Neuroscience and Center for in the right order to protect IP,” says Terry Cenergy. Neuroscience at CU-Boulder, has found Opgenorth, Executive Director of NeoTREX. Advanced Microlabs, which originally several avenues to apply her research on As technology progresses, support licensed technology from CSU in 2003, glial cells. These cells surround neurons and continues with active “industry engagement is currently engaged in developing novel play an important role in amplifying pain on licensing and research collaboration methods to test water purity for the power- but are ignored by current pain management opportunities,” Opgenorth continues. generation industry. The Company received therapies. The first startup company based Sometimes advisers serve as “‘executives a $995,000 grant in January from the NIH on her research, Xalud Therapeutics, is in residence’ with CSU startup companies, Superfund Research Program and the pursuing a non-viral gene therapy (XT101) providing invaluable guidance on how to National Science Foundation to push this that “completely reverses pain in rats for move from the academic environment to the technology toward commercialization. CSU three months by driving production of a business environment.” Professor of Chemistry, Charles Henry serves natural protein that calms down the glial Notable bioscience companies that have as CEO of the company. Advanced Microlabs cells,” Watkins says. She also connected with an existing therapeutics company to test a compound, ATL313, which is capable of transforming glial cells from activated to basal states. In testing in rats to evaluate the drug’s efficacy in reducing chronic pain from multiple sclerosis, the compound stopped the progression of MS-caused paralysis, a finding Watkins wants to investigate further. Finally, Watkins, CU-Boulder Professor Hubert Yin, and Professor Tarek Sammekia and Kenner Rice at the National Institute of Drug Abuse are aiming to optimize new molecules that block the activation of glial cells. BDEGP state funding will allow the team to “complete the ongoing structure- activity relationship studies and in vivo animal tests, thereby identifying pharmacophore for further drug development,” according to Yin. The group hopes to license the research to a pharmaceutical company or form a new startup. The benefits that accrue when researchers become engaged in the commercialization process reach far beyond any specific research pursuit. As Holmes of the CU School of Medicine says, “Now we are able to encourage our students and colleagues to consider various pathways to commercialization when opportunities arise in their own research.”

10 2011/2012 BIOSCIENCE COLORADO Colorado By the Numbers:

A 2011 Update on company 2009 2010 1 Accelr8 Technology Corporation $244,479 $0 2 Actium Biosystems, LLC $0 $244,479 Colorado’s Growing 3 Allos Therapeutics, Inc $1,466,875 $0 4 ApopLogic Pharmaceuticals, Inc $306,732 $0 5 Aqueous Biomedical Inc. $70,737 $155,000 Bioscience Industry 6 ARCA Biopharma Inc $488,959 $0 7 ArcScan, Inc. $244,479 $0 8 AspenBio Pharma Inc $244,479 $0 9 Beacon Biotechnology LLC $180,127 $64,352 10 BioAMPS International, Inc $0 $183,913 11 Biodesix Inc $844,318 $354,617 12 BiOptix Diagnostics, Inc. $227,575 $16,904 13 Bolder Biotechnology Inc. $326,913 $865,232 n 2009 the Internal Revenue Service, in conjunction with the Department of 14 Cell Point $244,479 $0 Health and Human Services, approved applications for the Qualifying Thera- 15 CeMines Inc $197,726 $0 peutic Discovery Bioscience Project Program, from applicants who demon- 16 Cerapedics Inc $733,438 $0 strated significant potential to produce new therapies to treat areas of unmet 17 CereScan Corp $244,479 $0 18 Chata Biosystems, Inc $67,800 $176,680 Imedical need or to prevent, detect or treat chronic or acute disease and conditions, 19 Clovis Oncology Inc $244,479 $244,479 significantly advance the goal of curing cancer within thirty years, and/or reduce 20 Corgenix Medical Corporation $26,250 $72,500 the long-term growth of healthcare costs in the U.S. Under the program, a total 21 Crestone, Inc $46,133 $199,725 amount of $1 billion was allocated for credits and grants with a $5 million limit 22 EndoShape, Inc $191,838 $209,035 per each eligible applicant. Over sixty Colorado-based life science entities quali- 23 Eveia Medical,Inc $0 $244,479 24 Generations Medical Partners LLC $0 $244,479 fied for and received nearly $25M in Therapeutic Discovery Grant awards, with 25 GlobeImmune, Inc. $730,828 $2,610 amounts ranging from $60,000 to over $1,400,000. 26 Greffex, Inc $244,479 $0 27 Hiberna Corporation $63,551 $33,592 Therapeutic Discovery Grant Awards 28 ICVRX LLC $0 $244,479 29 Inviragen, Inc $357,493 $131,466 30 Isogenis, Inc $244,479 $0 Larimer Weld 31 Kestrel Labs, Inc $244,479 $0 32 Lanx, Inc. $119,000 $125,479 33 Leap Frogg, LLC $189,970 $54,510 34 MBC Pharma Inc $244,479 $0 29 56 35 Micro-Imaging Solutions LLC $244,479 $0 18 60 36 MicroPhage Inc $488,958 $0 37 Miragen Therapeutics, Inc. $244,479 $0 38 Myocept, Inc $78,224 $166,255 48 42 36 58 19 31 39 N30 Pharmaceuticals, LLC $0 $244,479 12 53 52 2 44 40 Ocutronics, LLC $76,411 $168,068 Boulder 27 13 23 41 Otologics, LLC $244,479 $0 41 54 32 25 37 46 11 42 Parascript, LLC $244,479 $0 21 55 6 Broomfield 43 PARE Surgical, Inc. $127,457 $117,022 20 16 Gilpin 44 Pathogen Systems d/b/a Crystal Dx $244,479 $0 3 50 24 Adams 45 PharmaJet Inc $91,876 $152,603 7 1 17 46 Precision Photonics Corp dba mBio Dx $244,479 $0 15 35 45 47 ProFoldRx, Inc dba BaroFold, Inc $0 $244,479 Clear Creek 51 Denver 38 40 57 9 27 26 34 Arapahoe43 48 Protectstyle Corporation $0 $244,479 4 Jefferson 59 10 14 49 Pyxant Labs Inc $0 $98,733 61 22 30 39 47 50 Quest Product Development Corp $488,959 $0 Technology Legend 51 Rocky Mountain Biosystems, Inc. $273,760 $0 Medical Device 52 Somalogic Inc $1,439,985 $465,382 8 Biopharma 53 Sophono Inc $82,121 $162,358 Diagnostic Douglas 54 Source MDx $527,795 $205,643 GreenBio 55 St Cardio Technologies $186,139 $58,341 Other 56 St. Renatus LLC $244,479 $0 33 57 Sundance Diagnostics, Inc $244,479 $0 Mesa County, Grand Junction, CO 58 Surefire Medical, Inc. $12,576 $231,903 El Paso 59 ValveXchange, Inc $244,479 $0 5 49 60 Ventria Bioscience $389,918 $281,541 61 Vitrolife Inc $244,479 $0 Total $15,790,024 $6,709,299

BIOSCIENCE COLORADO 2011/2012 11 1 3Q Matrix 2 A2BE Carbon Capture 3 Accuthera 4 Advanced Headache Intervention New companies formed 2007-present 5 Advanced Microlabs 6 ApopLogic Pharmaceuticals 7 ArcScan Inc. 8 Beacon Biotechnology 9 BioAMPS International 10 Biodesix 11 BlueSun 12 Caveo Therapeutics Weld 13 Chemizon Larimer 14 Clarimedix 15 CycleGen 17 16 EndoShape 22 17 FireFly Medical 5 18 Fluonic 33 48 19 HepQuant 49 20 Hiberna 25 13 Middlesex County, 21 Illumasonix 39 18 27 Hopkinton, MA 22 KromatidTiD 2 9 23 Lanx 51 Boulder 14 10 24 Locomotion 50 25 16 11 57 15 23 25 mBio Diagnostics 43 24 20 40 19 35 46 26 Miragen Pharmaceuticals Broomfield 6 45 30 12 34 8 27 OPX Biotechnologies Gilpin 21 36 52 31 Adams 28 Onco Theix 3 32 41 44 47 29 pico-tesla Magnetic 7 Therapies 38 29 55 28 Clear Creek 4 30 Precision Biopsy 59 53 56 58 42 Arapahoe 31 Sierra Neuropharmaceuticals Jefferson 32 Snoasis Medical 33 Solix Biofuels Technology Legend 34 Taiga Biotechnologies Medical Device 35 Tissue Genetics Biopharma Diagnostic 36 ValveXchange Douglas 37 V-Clip Pharmaceuticals GreenBio 38 Ventrus Biosciences Other 39 Vitrumed 40 MycoLogics

41 AmideBio 37 42 Analytical Research System 54 El Paso 43 InDevR Mesa County 44 Qgenta Grand Junction, CO 45 Allogenesis 46 Western States Biopharma 47 Isogenis 48 Tolmar 49 Biotricity Medical 50 Actium Biosystems, LLC 51 Eveia Medical,Inc 52 Medical Partners LLC 53 ICVRX LLC 54 Leap Frogg, LLC 55 Myocept 56 Ocutronics, LLC 57 Sophono 58 Peptivir 59 Ariel Pharma

12 2011/2012 BIOSCIENCE COLORADO Institutional Financings 2007 to Present COMPANY ROUND/EVENT VALUE ($M) 1 Accera Series C $35.0 2 AllosTherapeutics Seconday $65.2 Allos Therapeutics Secondary $50.5 3 ARCA biopharma Series B 18.0 4 Array Biopharma Debt + Warrants $80.0 5 Aspen BioPharma Secondary $18.2 6 BaroFold Series A $12.0 7 Biodesix Series B Undisclosed 8 BiOptix Series B Undisclosed 9 CeraPedics $12.3 10 Evolutionary Genomics Series A $5.0 11 GlobeImmune Series C $41.2 Larimer Weld 12 IBalance Medical Series A $13.5 13 Illumasonix Series A Undisclosed 36 14 Lanx Series A $25.0 Technology Legend 15 MD-IT Series B $11.0 Medical Device 4435 Biopharma 16 16 Microphage Series A $11.0 35 30 11 48 50 38 Diagnostic 17 Miragen Series A $8.0 4735 6 24 GreenBio 51 15 17 31 Boulder 10 18 N30 Pharma Series A Undisclosed 4 12 Other 32 Boulder 14 19 OPX Biotechnologies Series A $3.6 19 29 8 1 3 3545 11 18 20 OberonFMR Series A $1.0 34 53 49 52 28 22 4635 39 9 7 2 4335 41 21 Precision Biopsy Series A Undisclosed Broomfield 25 37 22 Range Fuels Series B $130.0 Gilpin 23 21 Adams 40 13 23 Sierra Neuropharma Series A $21.5 33 27 24 SomaLogic Series D $35.0 20 25 Taligen Therapeutics Series B $65.0 Denver Clear Creek 26 TheraTogs Series A $1.1 Jefferson Arapahoe 27 Luca Technologies Series C $76.0 28 Medivance Series E $8.1 29 Clovis Oncology Series A $146.0 30 OPX Biotechnologies Series B $17.5 5 42 31 CeraPedics Series B $14.5 Elbert 32 BiOptix Series A $3.0 Douglas 33 AmideBio Seed Undisclosed 34 GlobeImmune Series E $17.5 35 GlobeImmune Milestone payment $40.0 36 Inviragen Series A $15.0 Teller El Paso 37 Sharklet Series A $1.5 38 miRagen Series A2 $ 4.0 Colorado 39 Array Biopharma Debt + Warrants $40.0 40 BioAMPs Seed $0.1 26 San Miguel County, 41 Allos Therapeutics Secondary $93.0 Telluride, CO 42 AspenBio Pharma Secondary $8.7 43 Accera Series D $11.0 44 SomaLogic Series E $15.0 45 Biodesix Series C $7.1 46 GlobeImmune Series E $17.5 47 N30 Pharma Series B $17.5 Sub-total | Capital Raises $1,788.1 48 Dharmacon Acquired $80.0 49 Sima Acquired $1,100.0 50 Pharmion Acquired $2,900.0 51 Myogen Acquired $2,500.0 52 RxKinetix Acquired $115.0 53 Insmed Acquired $130.0 Sub-total | Exits $6,825.0 Total | Capital Infused to Colorado $8,613.1

BIOSCIENCE COLORADO 2011/2012 13 Colorado-Based and Related ColoradoPu-Bblicased C&ompanies Related Public Compa- nies 1 Accelr8 Technology AMEX: AXK Larimer Weld 2 Agilent Technologies NYSE: A

19 3 Allos Therapeutics NASDAQ: ALTH 31 4 Alpharma Animal Health/ NYSE: KG Technology Legend King Pharma Medical Device Biopharma 5, 6 Amgen NASDAQ: AMGN 23 5 4 Diagnostic 7 Array Biopharma NASDAQ: ARRY 27 25 32 GreenBio 8 AspenBio Pharma NASDAQ: APPY 28 15 20 Other Boulder 2 34 9 B2 Health NASDAQ: BTWO 29 17 14 33 24 7 30 16 21 4235 10 BioNovo NASDAQ: BNVI Broomfield 3 11 Ceragenix Pharmaceuticals OTC BB: CGXP.OB Gilpin 10 Adams 12 Cochlear Americas ASX: COH 18 40 26 1 11 13 Conmed NASDAQ: CNMD Denver 14 Corgenix Medical NASDAQ: CONX.OB 38 12 15 Covidien NYSE: COV 22 13 Arapahoe Jefferson 39 16 Dharmacon/ NYSE: TMO Thermo Fischer Scientific 17 Encision NASDAQ: ECIA.OB 41 8 18 GeneThera NASDAQ: GTHR.PK Elbert 19 Heska NASDAQ: HSKA Douglas 20 Hospira NYSE: HSP 21 InB:Paxis / Hauser CRO/ NASDAQ: INBP Integrated BioPharma 22 Inhibiton Therapeutics NASDAQ: IHBT 36 23 Insmed NASDAQ: INSM Teller 24 Martek Biosciences NASDAQ: MATK 25 Medtronic NYSE: MDT 9 El Paso 26 Mesa Labs NASDAQ: MLAB 27 Myogen/Gilead NASDAQ: GILD 28 OrthoNextx NASDAQ: ANTX.OB 39 OSI Pharmaceuticals NASDAQ: OSIP 30 Pharmion/Celgene NASDAQ: CELG 31 QLT NASDAQ: QLTI 32 Replidyne/ NASDAQ: RDYN CardioVascular Systems 33 Roche Colorado VTX: ROG.VX 34 Sandoz NYSE: NVS 36 Spectranetics NASDAQ: SPNC 38 The Sorin Group MTAX: SRN.MI 39 VitroLife SEK: VITR 40 Xelr8 Holdings AMEX: BZI 41 Zynex NASDAQ: ZYXI.OB 42 ARCA biopharma NASDAQ:ABIO

14 2011/2012 BIOSCIENCE COLORADO Colorado Recent Financings January 2011 n Green-Bio n Biopharma n Medical Device n Diagnostic n Other

COMPANY CITY/ZIP ROUND/EVENT VALUE ($M) TECHNOLOGY/PRODUCT 1 Accera Broomfield / 80021 Series C $35.00 Medical Foods | CNS 2 Allos Therapeutics Westminster / 80020 Secondary $65.20 Small molecule THx | Oncology 3 Allos Therapeutics Westminster / 80020 Secondary $50.50 Small molecule THx | Oncology 4 ARCA biopharma Broomfield / 80021 Series B $18.00 Small moleculer THx | Cardiovascular 5 Array Biopharma Boulder / 80301 Debt + Warrants $80.00 Small molecule THx | Oncology 6 Aspen BioPharma Castle Rock / 80104 License Agreement Undisclosed Protein THx and Dx | Reproduction, Appendicitis 7 Aspen BioPharma Castle Rock / 80104 Secondary $18.20 Protein THx and Dx | Reproduction, Appendicitis 8 Arterain Medical Atlanta / 30313 Series A Undisclosed 9 BaroFold Boulder / 80301 Series A $12.00 Protein THx | Immunologic disorders 10 Biodesix Broomfield / 80021 Series B Undisclosed Dx Platform | Oncology 11 BiOptix Boulder / 80301 Series B Undisclosed Dx Platform | Infectious Diesease 12 Ceragenix Denver / 80202 Milestone payment $1.00 Medical Device | Infectious Disease 13 Ceragenix Denver / 80202 Milestone payment $1.50 Medical Device | Infectious Disease 14 CeraPedics Broomfield / 80021 Series A financing $12.30 Medical Device | Bone Graft 15 Evolutionary Genomics Lafayette / 80026 Series A $5.00 Biofuels Greentech 16 GlobeImmune Louisville / 80027 Series C $41.20 Discovery and development of potent, targeted molecular immunotherapies 17 iBalance Medical Boulder / 80301 Series A $13.50 Medical Device | Orthopedic 18 Illumasonix Aurora / 80045 Series A Undisclosed Dx Platform | Cardiovascular 19 Lanx Broomfield / 80021 Series A $25.00 Medical Device | Orthopedic 20 MD-IT Boulder / 80301 Series B $11.00 Telemedicine | Electronic Records 21 MedShape Solutions Atlanta / 30318 Series A Undisclosed 22 Microphage Longmont / 80503 Series A $11.00 Dx Platform | Infectious Diesease 23 Miragen Boulder / 80301 Series A $8.00 miRNA | Cardiovascualr 24 N30 Pharma Boulder / 80301 Series A Undisclosed Small molecule THx | Respiratory 25 OPX Biotechnologies Boulder / 80301 Series A $3.60 Biofuels Greentech 26 OberonFMR Idaho Springs / 80452 Series A $1.00 Biofuels Greentech 27 Precision Biopsy Aurora / 80045 Series A Undisclosed Dx Platform | Oncology 28 Range Fuels Broomfield / 80021 Series B $130.00 Biofuels Greentech 29 Sierra Neuropharma Aurora / 80045 Series A $21.50 Small molecule THx | CNS 30 SomaLogic Boulder / 80301 Series D $35.00 Dx Platform | Various Diseases 31 Taligen Therapeutics Aurora / 80045 Series B $65.00 Protein THx | Inflammation 32 TheraTogs Telluride / 84135 Series A $1.10 Medical Device | Orthopedic 33 Luca Technologies Golden / 80401 Series C $76.00 Biofuels Greentech 34 Accera Broomfield / 80021 Series D $11.00 Medical Foods | CNS 35 SomaLogic Boulder / 80301 Series E $15.00 Dx Platform | Various Diseases 36 Biodesix Broomfield / 80021 Series C $7.10 Dx Platform | Oncology 37 GlobeImmune Louisville / 80027 Series E $17.50 Discovery and development of potent, targeted molecular immunotherapies 38 N30 Pharma Boulder / 80301 Series B $17.50 Small molecule THx | Respiratory

Total Capital Raises $809.70

39 Dharmacon Lafayette / 80026 Acquired $80.00 RNAi oligos 40 Sirna Boulder / 80301 Acquired $1,100.00 RNAi THx | Oncology 41 Pharmion Boulder / 80301 Acquired $2,900.00 Small molecule THx | Oncology 42 Myogen Boulder / 80301 Acquired $2,500.00 Small molecule THx | Cardilogy 43 RxKinetix Louisville / 80027 Acquired $115.00 Small molecule THx | Oncology

Total Exits $5,515.00

TOTAL Capital infused to Colorado $6,324.70

BIOSCIENCE COLORADO 2011/2012 15 Discovery Valley of Death Preclinical FDA Review Clinical Trials FDA Approval Market

Weaving a Web of Support and Guidance

By Casey Demchak

reating a successful bioscience com- molecular biology, many research institutions partner in the Colorado Institute for Drug, pany isn’t for the faint of heart. What now have the opportunity to impact drug dis- Device and Diagnostic Development (CID4). is required is a tremendous amount of covery and development through specialized Through initial funding from the state of guts, determination, money, and most expertise and/or proprietary libraries. Colorado and the Fitzsimons Redevelop- Cimportantly — great science. Combining Also assisting in early-stage drug development Authority, CID4 is a source of funding these elements into a strong asset and taking it ment is the Colorado State University’s Colo- and entrepreneurial expertise that can help from the lab to clinical trials and on to market rado Center for Drug Discovery (C2D2). As a transform new bioscience technologies into launch is no simple task. It requires crossing a statewide resource, C2D2 addresses a severe commercial success stories. CID4 does this chasm or “valley of death” that can drain the hurdle — supporting the discovery of phar- by identifying and funding innovations with life from promising new technologies. macologically validated drug candidates with strong potential and by backing them with Here in Colorado, through a collective patent-protected chemical matter by focusing their extensive management expertise. effort involving state government and a web their resources on chemical optimization with “The mission at CID4 is simple,” says of highly dedicated institutions, there is an an eye toward drug candidate formulation. CID4 CEO Kevin Smith. “We aim to take big amazing array of work being done with the C2D2 uses a selective solicitation process ideas that show promise and turn them into shared goals of helping young companies to identify Colorado research institution drug drugs or devices that create jobs and further thrive and further developing the state’s bio- discovery projects that would be a good fit the statewide growth of Colorado’s biosci- science industry and overall economy. for their assistance. “The appeal of C2D2 ence infrastructure.” is that all of our principals are experienced Through its application process, CID4 E- arly stage support biopharma scientists,” says C2D2 Co-director seeks to take on two or three projects per year, Early-stage drug discovery is being Terry Opgenorth, Ph.D. “So we have a lot with equal consideration to drug and device assisted by the University of Colorado’s of experience to help move things forward development. CID4’s funding structure varies Colorado Initiative in Molecular Biotech- because we have seen many of the problems depending on the project, but it always in- nology (CIMB), which is developing the that can arise during drug discovery.” cludes equity for the technology founders and Integrated Novel Therapeutic Discovery C2D2 Co-director Joe Guiles, Ph.D., adds, a commitment to seeking additional outside Center (INTDC). This innovative facility will “What we do with programs we’ve selected funding for the companies that are formed. help researchers identify and validate novel is guide their research — acting more as a Two companies were formed or selected drug targets and promote multidisciplinary consultant. We listen to the scientists and through CID4’s first technology solicitation collaborations. INTDC will ultimately help what their goals are, and then we advise in Spring 2010. One was PeptiVir, which investigators transform their ongoing biologi- them on what we feel is realistically feasible is looking at creating a vaccine approach cal research. and achievable. So far, the various academic to treating influenza and other viruses. The This is also the goal of the University of bodies we have worked with have been very second company was Sophono, which has Colorado at Denver School of Pharmacy. receptive to our suggestions.” licensed the rights to a hearing device that Its High-Throughput Screening (HTS) core was approved in Europe and CE markets. facility leads to drug discoveries that have Nurturing developing companies shown success in increasing the chances of Technologies that have begun to show Moving closer to market realizing novel therapeutics. With technologi- promise, but still need help crossing the Companies that have developed to a point cal advances in genomics, proteomics and so-called “valley of death” have a potential where their technology is viable and their

16 2011/2012 BIOSCIENCE COLORADO help them define the best applications of their technology and work with them to put in place the resources they need to execute their strategy.” In addition, FBBp helps companies raise funding through angel or venture capital investors. It can also help connect new play- ers with big pharma, diagnostic or medical device companies that might be interested in creating partnerships. One of the companies that has ben- efited from the services offered by FBBp is Sharklet™ Technologies, which developed the world’s first technology to inhibit bacte- Kevin Smith, President and Chief Executive companies conduct R&D and other business rial growth through pattern alone. Sharklet Officer of CID4, with Richard Duke, CID4 operations. Technologies had a great year in 2010 when Founder and Chief Scientific Officer, at The center opened in September 2010 and it received the Colorado BioScience As- headquarters in the Colorado Science + is the home of C2D2 and four startup com- sociation Rising Star Award. The Company Technology Park at Fitzsimons. Photo by panies, two of which are university startups. also earned the Dorsey & Whitney Venture Kathleen Lavine and the Denver Business The other two companies are external startup Showcase Award at the 2010 BioWest Journal. companies that were drawn to the center conference. by its unique model that mixes academic basic business structure is in place also have researchers in the same space as business Looking ahead allies to help them grow and attract more entrepreneurs. Through the combined work of so many funding. Fitzsimons BioBusiness Partners (FBBp) great organizations, Colorado’s bioscience The Colorado State University Research is another key organization helping young industry has reason to feel optimistic about Innovation Center (RIC) provides premiere Colorado bioscience companies get their its future. Within the bioscience community incubator space for new companies and footing. FBBp is a division within the Fitzsi- there is a unique realization that the state is serves as a vehicle for performing collabora- mons Redevelopment Authority, and it is much stronger when government, universi- tive translational-stage research with CSU’s responsible for nurturing sustainable biosci- ties and industry institutions collaborate on community of life-science investigators. ence businesses to establish a global position economic development issues. The new 56,000-square-foot facility is a for the industry at the Colorado Science + By garnering continued support from state hybrid life-science accelerator and academic Technology Park at Fitzsimons. government and the entrepreneurial spirit that research building. Approximately 18,000 “FBBp was created to support the needs has built the industry, Colorado has an excel- square feet of the three-story building is the of Colorado bioscience companies so they lent opportunity to take its place as one of the life-science accelerator. The entire facility could gain traction and begin to thrive,” says nation’s elite centers for bioscience discovery is designed to help start-up and established FBBp Director Michael Artinger, Ph.D. “We and development.

BIOSCIENCE COLORADO 2011/2012 17 Discovery Valley of Death Preclinical FDA Review Clinical Trials FDA Approval Market When the going gets tough, the tough get creative financing

By Adam Rubenstein $ $

$nduring economic turbulence combined with health-care legislation uncertainty has continued to pummel the entire lifesciences sector, from big pharma to the grant-supportedE academician. Whatever your favorite barometer of financing for our industry — be it PriceWaterhouseCoopers Mon- eyTree Report, the National $Venture Capital Association or OnBioVC.com — the message was loud and clear: 2010 was the worst year of the past decade for venture financing in the Lousiville, CO-based GlobeImmune, a late a clinically validated blood test that helps life sciences industry. Early-stage discovery clinical-stage biopharmaceutical company physicians guide treatment for patients with and development bioscience companies have focused on therapeutic vaccines for the treat- advanced non-small cell lung cancer, recently seen access to risk capital, both from public ment of infectious diseases and cancer, closed became commercially available. granting agencies such as the NIH and private a $17.5 million Series E financing. Just down Near the Flatirons, N30 Pharmaceuticals equity sources such as venture capital, signifi- the road in Broomfield, CO two companies and SomaLogic, two Boulder, CO-based cantly diminish. closed follow-on financings: Ac- entities, also closed follow-on rounds. N30 In the face of this adverse fundraising back- cera locked in an $11 million Series D, while booked a $10 million Series B financing and is drop, however, Colorado companies raised Biodesix collected $7.1 million in Series C now a clinical-stage pharma company having nearly $100 million in venture capital, with financing. Accera is developing therapeu- dosed their first Phase I patient in September financings distributed across a broad spectrum tic treatments for central nervous system 2010 with N6022, a first-in-class inhibitor of of sectors, including therapeutics, vaccines, disorders such as Parkinson’s disease and has s-nitrosoglutathione reductase for the potential diagnostics, medical foods and personalized already commercialized Axona®, a medical treatment of inflammatory-based diseases such medicine. Colorado’s “git’er done” cowboy food designed to address metabolic deficien- as asthma, chronic obstructive pulmonary spirit, which permeates our life-science cies in Alzheimer’s patients. disease (COPD) and inflammatory bowel ecosystem, and savvy growth approaches Biodesix is advancing personalized patient disease (IBD). developed by unique local sources, made care by providing clinicians with important If you are looking for the frontlines of the 2010 another successful year of world-class information relating to a patient’s diagnosis, personalized medicine revolution, you need biomedical research and development up and prognosis, or response to a specific therapy. not look any further than SomaLogic, which down the Front Range. The Company’s first product, Veristrat®, closed a new $15 million round. The Com-

18 2011/2012 BIOSCIENCE COLORADO pany is developing unique proteomic reagents Revenue Service and Department of Health four years or less into their first academic known as SOMAmers®. This aptamer- and Human Services, approved applications appointment at a research institution. It is not based array technology unlocks biomarker for bioscience projects that show significant uncommon for ECIs to have a difficult time discovery, enabling the detection of even the potential to produce new, cost-saving thera- acquiring support for their first opportunity at rarest of disease-associated proteins quickly, pies, support job creation, and increase U.S. an independent research effort that aids their concurrently, effectively and economically. competitiveness. With a total of $1 billion move out of the shadow of their mentors into These follow-on financings, backed by inin credits and grants, the program awarded their own areas of discovery. stitutional capital from U.S. and international up to $5 million per each eligible applicant. Continuing the process, the Boettcher sources, speak to the progress toward regula- More than 60 Colorado-based life-science Foundation, Webb-Waring Foundation for tory approval and commercialization from a entities qualified for nearly $25 million in Biomedical Research and the University of diverse set of Colorado companies. Therapeutic Discovery Grant awards, with Colorado, formed the Webb-Waring Biomedi- Geographically concentrated venture amounts ranging from $60,000 to more than cal Research Program to support the work of financing events may be viewed as a gauge $1,400,000. See the Therapeutic Discovery early-career investigators in the biomedical of the perceived quality of a region’s in- Grant map on page 11 for a list of recipients. field. Six grantees were named in the 2010 novation, intellectual property and human Colorado takes a holistic approach to de- Inaugural Class of Boettcher Investigators, capital. A second metric that points toward veloping its bioscience ecosystem, recogniz- representing National Jewish Health, the the local quality of life-science products with ing the importance of the very earliest por- University of Colorado, Colorado School of a commercial trajectory is the Qualifying tion of the innovation funnel that transpires in Mines and Colorado State University. Indi- Therapeutic Discovery Project. The grant the laboratories of early-career investigators vidual grant amounts ranged from $200,000 program, launched in 2009 by the Internal (ECIs). ECIs are faculty members who are to $300,000, providing a total of more than

BIOSCIENCE COLORADO 2011/2012 19 $1 million of support per year. ence industry with the intent of stimulating through the Governor’s Office of Economic Colorado has a true public-private commit- new bioscience job growth and company Development and International Trade and ment to fostering the growth of the industry. creation. The program provides five years of require a one-to-one matching source. As In 2006, the Colorado General Assembly funding through FY 2012-13, at approximate- of April 2011, nearly $19 million had been created the Bioscience Discovery Evaluation ly $5.5 million each year. The funds, raised distributed. The legislature recently extended Grant Program (BDEGP) to grow the biosci- from gaming revenues, are appropriated the program to 2018 injecting another $25 million into the program. In addition, Senate Bill 47 was passed — creating approximately $2 million per year in additional funding from state corporate income tax withholdings from growth of bioscience companies. Methods of distribution include: • Proof-of-Concept (POC) grants, of up to $150,000, to research institutions, • Early-Stage Company (ESC) grants, of up to $250,000, to companies that have licensed intellectual property from a Colorado research institution, and • Commercialization Infrastructure grants to enable the creation of a diverse set of resources often required to support translational-oriented academicians and early-stage companies. join us www.pvhs.org/research The BDEGP has been recognized nationally as one of a handful of best-practices for state legislatures by the Biotechnology Industry Organization (BIO). Out of 79 BDEGP POC grants awarded to date, 21 new companies have been created, with more promising Colorado companies in the pipeline. The ESC grants have aided 23 companies in achieving critical milestones in their evolution; those companies include 2C Tech, Advanced MicroLabs, Apop- Logic, BioAMPs, ClariMedix, EndoShape, Flashback Technologies, HepQuant, Hiberna, Illumasonix, InDevR, KromaTiD, MicroPhage, Oberon, PolyNew, QGents, Quest Product Development, SierraNeuro, Snoasis Medical and ValveXchange. Be- tween POC, ESC and Infrastructure grants, the BDEGP has accounted for 598 new direct and indirect jobs within the state, with a total payroll of more than $44 million. An additional $68 million has been leveraged through follow-on investment, grants and matching funds, yielding approximately 8.3 times the programs distributed funding. A thoughtful approach to address the needs of the rapidly accelerating early-stage community has been addressed by four BDEGP Infrastructure grants. Recipients include: Colorado State University’s Colorado Institute for Drug Discovery (C2D2), which provides a suite of resources, from medicinal chemistry to PK to ADME assays, compound library screening, informatics and more. These capabilities are designed to accelerate drug discovery research statewide.

20 2011/2012 BIOSCIENCE COLORADO The University of Colorado, Boulder, Despite a climate of relatively constrained array of public resources is working to lever- which is now home to the Colorado Initiative financial resources across the country, Colo- age follow-on resources, as finite as they in Molecular Biotechnology (CIMB), led by rado continues to attract institutional capital might be, to continue to catalyze the world- Nobel laureate and former President of the along with the participation of local angels class research, development, clinical and Howard Hughes Medical Institute, Tom Cech. and successful serial biopreneurs. In addition commercial products derived from Colorado’s CIMB focuses on enhancing core research to these private resources, a new and diverse talented work force. areas at the forefront of molecular technologies applied to biosciences, creating a magnet for attracting and retaining outstanding students and faculty, bridging disciplines by 2012 Life Science Research Conferences integrating research and teaching and pro- eystone Symposia’s 55 conferences in its 2011-2012 meeting season moting interdisciplinary collaborations, and Kcover the full range of the biomedical/life sciences from infectious supporting biotechnology development along disease, immunology, cancer and cardiovascular/metabolic disease to the Front Range. neuroscience, drug discovery and genetics/genomics. They include: The University of Colorado, Denver, • High-Throughput Structural Biology – January 22-27, 2012, through the Department of Pharmacology’s Keystone Resort, Keystone, Colorado High-Throughput Screening (HTS) core • Chemical Biology and Novel Tools in Pharmacology – February 12-16, facility, where screening of compound librar- 2012, Hilton Santa Fe, Santa Fe, New Mexico ies against potential therapeutic targets is • Addressing the Challenges of Drug Discovery – Novel Chemical performed and validated. Targets, New Chemical Space and Emerging Approaches – The Colorado Institute for Drug Device E SY March 19-23, 2012, Granlibakken Resort, Tahoe City, California N MP TO O and Diagnostic Development (CID4), a S S

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501(c)3 not-for-profit entity. C1D4’s mission Don’t miss these great opportunities to immerse yourself in the A 2 N 1 0 N 2 latest, groundbreaking research and forge new collaborations. I 40 - is to accelerate bioscience company and VE 72 RSARY 19 job growth in Colorado via select capital For a complete conference list visit infusions and active management designed www.keystonesymposia.org/meetings to help bridge the gap between life-science 1-800-253-0685 • 1-970-262-1230 PO Box 1630, Silverthorne, CO 80498 discovery and commercialization. Where bioscience means business Aurora is home to the Anschutz Medical Campus and Fitzsimons Life Science District, one of the largest bioscience redevelopment projects in the United States. The 578-acre site is undergoing a $5.2 billion transformation that will result in more than 18.5 million square-feet of space dedicated to excellence in health care, education and research.

Visit www.auroraedc.com for more information on Colorado incentives, our highly skilled workforce, and other resources that make Aurora the location for your next bioscience venture.

BIOSCIENCE COLORADO 2010/2011 21 Webb-WaringWebb-Waring BiomedicalBiomedical ResearchResearch ProgramProgram Boettcher Investigators Boettcher Investigators

InauguralInaugural ClassClass 20102010

Shaodong Dai, Ph.D., Assistant Professor of Immu- Paul Jedlicka, M.D., Ph.D., Assistant Professor of nology, National Jewish Health, Chronic Beryllium Pathology, University of Colorado – Anschutz Medi- LungShaodong Disease Dai, Ph.D., Assistant Professor of Immu- calPaul Campus, Jedlicka, Ewing M.D., Sarcoma, Ph.D. a, AssistantCommon Professor Cancer of of nology, National Jewish Health, Chronic Beryllium thePathology, Bone and University Soft Tissue of Affecting Colorado Children – Anschutz Medi- RobinLung Dowell, Disease D.Sc., Assistant Professor of Molecu- cal Campus, Ewing Sarcoma, a Common Cancer of lar, Cellular and Developmental Biology, University Keiththe Bone Neeves, and Ph.D.Soft Tissue, Assistant Affecting Professor Children of Chemical of Colorado at Boulder, Translational Bioinformatics Engineering, Colorado School of Mines, Role of Robin Dowell, D.Sc., Assistant Professor of Molecu- Involving Drug Efficacy and Genetics Blood Flow in the Formation of Blood Clots lar, Cellular and Developmental Biology, University Keith Neeves, Ph.D., Assistant Professor of Chemical of Colorado at Boulder, Translational Bioinformatics Engineering, Colorado School of Mines, Role of Gidon Felsen, Ph.D., Assistant Professor of Physiolo- Melissa Reynolds, Ph.D., Assistant Professor of Involving Drug Efficacy and Genetics Blood Flow in the Formation of Blood Clots gy and Biophysics, University of Colorado – Anschutz Chemistry, Colorado State University, Nitric Oxide Medical Campus, Parkinson’s Disease Releasing Materials for Cardiovascular Medical Gidon Felsen, Ph.D., Assistant Professor of Physiolo- DevicesMelissa Reynolds, Ph.D., Assistant Professor of Investigatorsgy and Biophysics, listed left to right University of Colorado – Anschutz Chemistry, Colorado State University, Nitric Oxide Medical Campus, Parkinson’s Disease Releasing Materials for Cardiovascular Medical Devices Investigators listed left to right Webb-Waring Biomedical Research Program Boettcher Investigators

Inaugural Class 2010 Congratulations Class of 2011 Zhe Chen, Ph.D., University of Colorado Boulder

Robert Doebele, M.D., Ph.D., University of Colorado Anschutz Medical Campus

Jing Wang, M.D., Ph.D., University of Colorado Anschutz Medical Campus

John D. (Nick) Fisk, Ph.D., Colorado State University

Tingting, Yao, Ph.D., Colorado State University

The Webb-Waring Institute was founded in 1924 by Dr. Gerald B. Webb and later directed by Dr. James J. Waring. For over 80 years, the organization contributed to the advancement of biomedical research by engaging in basic and clinical research and training research scientists. In 2008, the Webb-Waring Institute became a part of the Shaodong Dai, Ph.D., Assistant Professor of Immu- Paul Jedlicka, M.D., Ph.D., Assistant Professor of University of Colorado and is now known as the Webb-Waring Center. nology, National Jewish Health, Chronic Beryllium Pathology, University of Colorado – Anschutz Medi- The Boettcher Foundation was entrusted with the stewardship of the Lung Disease cal Campus, Ewing Sarcoma, a Common Cancer of Webb-Waring Foundation's assets. Through an innovative agreement the Bone and Soft Tissue Affecting Children between the Boettcher Foundation, the Webb-Waring Foundation and Robin Dowell, D.Sc., Assistant Professor of Molecu- lar, Cellular and Developmental Biology, University Keith Neeves, Ph.D., Assistant Professor of Chemical the University of Colorado, a new funding area was established at the of Colorado at Boulder, Translational Bioinformatics Engineering, Colorado School of Mines, Role of Boettcher Foundation that will support the work of early-career inves- Involving Drug Efficacy and Genetics Blood Flow in the Formation of Blood Clots tigators in the biomedical sciences in Colorado.

Gidon Felsen, Ph.D., Assistant Professor of Physiolo- Melissa Reynolds, Ph.D., Assistant Professor of For more information about the Boettcher Foundation, please visit gy and Biophysics, University of Colorado – Anschutz Chemistry, Colorado State University, Nitric Oxide www.boettcherfoundation.org. Medical Campus, Parkinson’s Disease Releasing Materials for Cardiovascular Medical Devices Investigators listed left to right Bioscience Discovery Evaluation Grant Program An effective economic development, job and company creation program

he Bioscience Discovery Evaluation Grant Program (BDEGP) was created in 2006 by the Colorado General Assembly to grow the bioscience industry in the state. The goal wasT to stimulate jobs and create new bioscience companies based on promising discoveries made at the state’s major research institutions. The $56 million program is appropriated through the Governor’s Office of Economic Development and International Trade (OEDIT). Since the first grants were made in mid-to-late 2007, the program has provided 116 grants to researchers at Colorado research institutions; 41 grants to help early stage companies further these technologies; and has formed four new bioscience commercialization organizations to identify, manage and support technologies and to bring together necessary expertise to advance novel Colorado biotechnologies to commercialization. A total of $19 million of the $56 million program has been granted through April 2011. Each grant is awarded following a rigorous review by scientists, bioscience executives, financiers, and OEDIT. Within this funding year (FY 2010-2011) 41 grants have been awarded as of April 2011, in three program areas: • 30 - Proof of Concept (POC) grants to research institutions to accelerate the development of new bioscience discoveries that may lead to the creation of new Colorado companies. • 8 - Early Stage Company Grants (ESC) to Col- orado companies that have licensed a bioscience technology from a Colorado research institution. • 3 – Commercialization Infrastructure grants to develop essential resources for Colorado scientists and bioscience companies.

24 2010/2011 BIOSCIENCE COLORADO 2010 -2011 PROOF-OF-CONCEPT GRANTS COLORADO SCHOOL OF MINES

Investigator: David Marr Ph.D.

Title: Cell Isolation Using DVD Optics

Research: The research has two goals in using DVD optics: 1) Optimization of microfluidic geometries and flows for cell isolation, and how to integrate these settings to sort cells; 2) Incor- poration of detection of cell location using integrated quadrant photodiode. Investigator: David W.H. Riches, Ph.D. Impact: Because of rising health-care costs, there is a significant need for inexpensive diagnostics and methods for drug screening Title: Therapeutic Small Molecule Inhibitors to Treat Pulmonary in the context of personalized medicine – techniques that allow for Fibrosis rapid and point-of-care testing of potential therapeutics. Available DVD optical pickups are technologically sophisticated yet incred- Research: Idiopathic pulmonary fibrosis (IPF) is a fatal lung ibly inexpensive due to their mass production and ubiquity in disease that severely limits the ability of patients to breathe. Two consumer electronics. The objective is to determine their practical thirds of IPF patients die within 3 years of diagnosis accounting utility for commercial biomedical device application. for approximately 45,000 American deaths every year. Unlike breast cancer, from which a similar number of American women die each year, there is no effective pharmacologic or biologic NATIONAL JEWISH HEALTH therapy for IPF.

Investigator: Richard Meehan, M.D. Impact: The goal of this project is to discover small molecule inhibitors (therapeutics) that block the interaction between Fas Title: Joint Aspirate Facilitator Device and PTPN13. The identification of such molecules could pave the way for an innovative therapeutic approach to the treatment of IPF. Research: Osteoarthritis (OA) is the most common cause of In addition, the same small molecule inhibitors could represent a disability in the elderly and 1/3 of individuals > 65 years of age new treatment for pancreatic and colon cancer where resistance have OA of the knee which is the most common joint needing joint to Fas-induced apoptosis also contributes to disease progression. aspiration (for diagnosis) or injection. Given the dismal responses of patients with IPF, colon and pancreatic cancers to current therapies, the approach might offer a new Impact: This project should develop a novel, relatively inexpen- avenue for treatment in the long term. sive, reusable or disposable device which can improve patient comfort in a medically important but underutilized procedure, joint aspirations and injections. Investigator: Gongyi Zhang, Ph.D., and John Cambier, Ph.D.,

Title: BCMA-Fc Chimeras as Therapeutics for Autoimmunity Investigator: Jerry Nick, M.D. Research: B cells play a critical role in a broad spectrum of hu- Title: A Novel Compound For Pseudomonas Biofilm Disruption man autoimmune diseases. These include not only those diseases that are mediated by autoantigen-reactive antibodies such as Research: This project will allow for synthesis of candidate Systemic Lupus Erythematosis, Idiopathic Thrombocytopenia molecules, using well-described drug-development modifications and Multiple Sclerosis, but also autoimmune diseases that have a of a current product, with the goal of identifying unique molecules prominent T cell effector component such as Type 1 Diabetes and with superior stability and bioavailability. These candidates will Rheumatoid Arthritis. then be tested in our model system of neutrophil-enhanced biofilm development on biofilm plates and contact lenses in vitro, followed Impact: The current best therapy for these diseases is Rituxan, an by in vivo testing of treatment of PA infections in a murine model antibody that targets B cells for destruction by phagocytic cells of thermal injury. found in the liver. While Rituxan holds great promise, it spares certain B lineage cells, and therefore is not effective in all situ- Impact: The proposed product will serve as an adjuvant to avail- ations. For example, clinical trials using Rituxan for SLE failed, able antibiotics, to prevent or disrupt the PA biofilm in early stages probably because the offending B cell population was not ef- of development, and improve efficacy of conventional treatment. If ficiently eliminated. Finally, the mode of action of Rituxan places successful, this will be the first product of its kind in this poten- patients at risk of a variety of infectious diseases. Specifically, tially very large medical market. Rituxan causes long-term depletion (sometimes 1-2 years) of B cells needed to fight infection. Clearly there is great need for effective alternative B-cell targeted therapies.

BIOSCIENCE COLORADO 2010/2011 25 Investigator: Philippa Marrack, Ph.D. and Anatoly Rubtsov, Ph.D. COLORADO STATE UNIVERSITY

Title: Generation of Bispecific Antibodies for Targeting Autoim- Investigator: Charles S. Henry, Ph.D. and Lawrence Goodridge, mune-Associated B Cells (ABCs) Ph.D.

Research: Current autoimmune disease treatments have been Title: Microfluidic Paper-Based Analytical Device for Detection mainly directed to preserve the body organs. These treatments can of Pathogenic Bacteria preserve organ function and reduce pain, but they fail to stop or cure the disease. Modern therapies for autoimmune diseases have Research: The goal of this project is to develop a sensor for the very profound effects on the whole immune system and tend to detection of foodborne pathogens using selective biological assays affect large populations of cells that are important for maintain- to be used in the food industry. ing protection of the host from pathogens. Investigators propose to generate a new type of antibody that will specifically deplete Impact: Diseases resulting from foodborne pathogens affect mil- a small population of autoimmune-associated B cells (ABCs) lions of people every year and represent a major health problem in recently identified by the likely source of autoantibodies in auto- developed and developing countries. Most foodborne illness can immune mice. be prevented with proper sterilization. Current monitoring methods are too slow, expensive, prone to interference, or too cumber- Impact: The plan is to design antibodies that will target a specific some for widespread implementation. The project outcome will population of cells that has been demonstrated to play a key role in result in a new technology that overcomes these problems and the production of autoantibodies. If the designed antibodies indeed addresses an area of significant need in the food industry. cause the depletion of ABCs, the product could become a powerful new drug in the treatment of a variety of autoimmune diseases. Investigator: Susan P. James, Ph.D. and Lakshmi Prasad Dasi, Ph.D. Investigator: Remy Kachadourian, Ph.D. and Brian J. Day, Ph.D. Title: Developing the Cardiovascular Applications of BioPoly™ Title: Combining Pro-Oxidant Effects to Kill Cancer Cells; A Mouse Model Study Research: The goal of this project is to develop BioPoly™ materials for use in cardiovascular blood-contacting applications. Research: The strategic objective of this project is to demonstrate BioPoly materials which are largely made of synthetic plastic have in an animal model the efficacy of a new approach to sensitize the mechanical properties of plastic – they are strong, flexible and cancer cells to alkylating agents. This new approach is based on durable. A small percentage of natural hyaluronan (HA) is also in- inducing glutathione (GSH) efflux through multi-drug resistant corporated into the materials and gives them water-loving, tissue- proteins (MRPs) that are activated by some flavonoids. Investiga- like surface properties. These materials are easy to manufacture tors plan to demonstrate in an animal model (mice), the benefits of into a variety of shapes. combining a GSH depleting agent with an alkylating agent. Impact: Cardiovascular BioPoly will meet critical needs in two Impact: The development of new and more efficient inducers large human health markets: 1) small-caliber vascular grafts that of GSH depletion may significantly impact cancer treatment by can be used in the over 1.4 million arterial bypass surgeries per- allowing the use of smaller treatment doses, resulting in better formed each year in the U.S.; and 2) leaflets for polymeric heart patient tolerance and compliance. Therefore, this project can po- valves in the roughly 400,000 heart valve replacement surgeries tentially lead to the commercialization of a library of compounds performed each year. that would be used in individualized medicine against cancer.

Investigator: Susan P. James, Ph.D. and David A. Prawel, M.S., Ph.D. Candidate

Title: Penetrating Osteointegrative Coatings for Titanium Lattice Implants

Research: Use electrospraying to deposit consistent, biocompatible coatings on titanium surfaces which will enhance integration of orthopedic implants into existing bone.

Impact: The proposed research would significantly enhance the clinical outcome of patients in the joint replacement and bone cancer reconstructive implant markets by improving natural bone growth, more deeply into the structure of these implants.

26 2010/2011 BIOSCIENCE COLORADO Investigator: Kenneth F. Reardon, Ph.D.

Title: Multichannel Optical Biosensor for Oxygen-Based Detec- tion of Organic Chemicals in Aqueous Media

Research: This project advances the technological state of an optical enzymatic biosensor platform by using biological and engineering approaches to increase the biosensor lifetime, improving the multichannel optoelectronic hardware system used for measuring analytes in mixtures, and developing multichannel calibration and measurement protocols. The multichannel optical biosensor will be used to detect contaminants in water and food.

Impact: The ability to easily and accurately monitor water and food supplies for contaminants has tremendous health and economic benefits. Investigator: E. Christopher Orton, Ph.D.

Title: Catheter-Delivered Artificial Heart Valve Device Investigator: Sybil E. Sharvelle, Ph.D.

Research: The goal of this project is to provide proof of concept Title: Development of a Multi-Stage Anaerobic Digester for Gen- of a novel catheter-delivered mitral valve replacement device. eration of Methane from Manure The device is designed to be delivered into the beating heart, thereby eliminating the need for open heart surgery or a heart Research: The goal of this project is to demonstrate the feasibil- lung machine (i.e. cardiopulmonary bypass). Thus, the device can ity of a novel multi-stage anaerobic digester system for convert- be delivered less invasively and in a much shorter period of time ing solid animal waste into biogas, specifically methane. The compared to traditional open heart surgery, and thereby would be modular, multi-stage design proposed should have advantages in safer in older and seriously ill patients. overcoming scaling issues and will be specifically suited for the arid conditions found in the western United States. Synergistic Impact: Approximately 65,000 heart valve repairs or replacements benefits include reduction of solid animal waste and generation of are performed in the United States each year. Currently, valve re- biogas onsite. pair or replacement usually requires traditional open heart surgery (i.e. cardiopulmonary bypass with a heart lung machine). Much Impact: Implementation of the reactor onsite will reduce solid of the morbidity associated with heart valve surgery is caused by animal waste and generate biogas that will partially offset an effects of cardiopulmonary bypass and the heart lung machine. operation’s energy expenses. This technology will be of benefit to The catheter-delivered mitral valve replacement device would many livestock operations, including large Concentrated Animal eliminate this problem. Open heart surgery is poorly tolerated in Feeding Operations (CAFOs) that typically include thousands of older patients and those with concurrent serious illnesses. This animals. device would potentially allow for many of these excluded patients to receive life-extending heart valve surgery. COLORADO INSTITUTE OF MOLECULAR BIOTECHNOLOGY

Investigator: Tomislav Rovis, Ph.D. Investigator: Natalie Ahn, Ph.D. & Tin Tin Su, Ph.D.

Title: Efficient Synthesis of New Resorcinylic Macrolide HSP 90 Title: Radiation Sensitizers for Cancer Anticancer Agents Research: The aim of this grant work is to optimize a small mol- Research: The aim of this research is to develop a general ap- ecule lead compound which synergizes with radiation, in order to proach to synthesizing a variety of resorcinylic macrolides using a develop novel compounds with a high combination index for use highly efficient polyketide cassette technology. These compounds in the radiation treatment of cancer. are expected to be inhibitors of heat shock protein HSP90, a promising antitumor target. A variety of resorcinylic macrolides Impact: Existing cancer therapies have key limitations, in that will be synthesized and screened for their antiproliferative activity targeted therapies are often so specific that they only benefit a small in tumor cells. The most promising candidates will be selected for subset of patients with a particular mutation, while chemotherapy the next stage of pre-clinical research. and radiation have devastating side effects due to toxicity. Combi- nation therapy using drugs which target different aspects of disease Impact: This work will specifically target the human anticancer progression is not only more therapeutic, but allows lower doses drug market, although it may have veterinary applications as well. of each to be used, thereby reducing side effects. Small molecule Deliverables include the synthesis and selection of promising drugs which increase the efficacy of radiation therapy may allow antitumor compounds based on resorcinylic macrolides, the most reduction of radiation doses or overall radiation exposure. Based on successful of which will be ready for the next stage of pre-clinical results thus far, the small molecule lead compound studied will be research. effective in combination with irradiation for treating cancer.

BIOSCIENCE COLORADO 2010/2011 27 Investigator: Natalie Ahn, Ph.D. & Xuedong Liu, Ph.D. Investigator: Christopher Bowman, Ph.D.

Title: A Highly Potent Histone Deacetylase Inhibitor For Cancer Title: Dual Core Polymer Systems for Biomedical Applications Therapeutics Research: The Project objective is to develop a dual cure polymer Research: The aim of this grant work is to optimize a small mol- system for orthopedic suture anchors and contact lenses for com- ecule inhibitor of histone deacetylases which shows high potency mercialization. and selectivity against human xenograft tumors and a panel of cancer cell lines. Impact: The successful development of a dual cure shape memory polymer as an orthopedic suture anchor would result in a product Impact: Ideal drugs for cancer therapy are those which selectively that is superior in several areas to current market products. The kill tumor cells, but spare normal cells. However, anti-cancer two stage cure allows minimally invasive deployment of the drugs which fulfill these criteria are extremely rare. Histone anchor coupled with a high-modulus, high-strength final fixed deacetylace (HDAC) inhibitors have emerged as one of the most device. promising targets for cancer therapies, given widespread evidence Parallel development of novel materials and processes for that inhibition of histone deacetylation promotes growth arrest, producing custom contact lenses, based on customer’s personal differentiation, and apoptosis of tumor cells, with minimal effects wavefront measurements, will result in corrective lenses that per- on normal tissues. The new proprietary compound identified in form significantly better than today’s lenses. These materials and structure activity relationships (SAR) studies, paragazole, appears methods will be applicable to the traditional contact lens wearers, to be superior to other known HDAC inhibitors in potency while and will also open new markets for patients requiring higher order maintaining selectivity. vision correction not currently possible with existing contact lens technology.

Investigator: Natalie Ahn, Ph.D. & Tarek Sammakia, Ph.D. Investigator: Leslie Leinwand, Ph.D. Title: Treatments for Chronic Pain Title: Novel Therapeutics for Pathological Cardiac Hypertrophy Research: The aim of this grant work is to develop new chemical entities structurally related to tricyclic antidepressants, which Research: The strategic objective of this grant is to develop remove antidepressant activity while acting as potent inhibitors specific fatty acid (FA) species as therapeutic tools to promote of the opioid-mediated TLR4 response. These will provide novel beneficial cardiac adaptation in the presence of pathological compounds which when used in combination with opiods, elimi- stimuli. Using the fed python as a model of extreme physiologi- nate side effects in treating chronic pain. cal adaption, the project aims to determine the ability of FAs to regulate mammalian heart cell size, function and gene expression Impact: Chronic pain occurs in epidemic proportions worldwide. in both in vitro cell culture and in vivo rodent models. The most effective therapeutics for the treatment of moderate to severe pain are opioids, all of which are prone to abuse, toler- Impact: There is a need for a better understanding of the intracel- ance, and dependence. Developing chiral tricyclic antidepres- lular pathways that differentially regulate physiological and patho- sants (TCAs) will provide a route to block side effects of opioids logical hypertrophy. The elucidation of the molecular pathways towards TLR4, while taking advantage of the blood-brain perme- that control enlargement of the heart remains a central question ability of TCAs. Resulting therapeutics will lessen the effects of in cardiovascular research and the identification of key physi- tolerance and dependence associated with opioids. ological vs. pathological effectors may provide novel therapeutic targets to prevent, reverse, or modify the pathological hypertrophic phenotype. Novel therapeutic targets can lead to new therapies for heart disease.

Investigator: Hubert Yin, Ph.D.

Title: Developing Novel Drug Candidates Optimizing Opiate’s Clinical Efficacy

Research: The Project objective is to develop agents that can optimize a promising, small molecule TLR4 inhibitor--T5342126- -to selectively block opioid-induced TLR4 activation and improve opioid pain relief while minimizing opioid dependence.

Impact: Because current pharmacotherapeutics have failed both to control pain and to avoid the negative consequences, there is an urgent need to develop the next generation pain management therapies.

28 2010/2011 BIOSCIENCE COLORADO UNIVERSITY OF COLORADO Investigator: Robert Hodges, Ph.D. & Kathryn Holmes, Ph.D. Investigator: Heide Ford, Ph.D. Title: A Novel Conformation - Stabilized, Synthetic Peptide Vac- Title: Identify Inhibitors Of The Six1-Eya Interaction for Anti- cine for Respiratory Syncytial Virus Breast Cancer Drug Design. Research: The Project objective is to develop a novel synthetic Research: The Project objective is to identify and develop inhibi- peptide vaccine to prevent Respiratory Syncytial Virus infection, tors targeting the interaction of the Six1 gene and its co-factor Eya a common respiratory virus impacting infants, the elderly and for anti-breast cancer drug design. others with weak immune systems. This application will provide further proof of concept that the underlying invention can serve Impact: This research is expected to benefit up to 50% of breast as a platform technology effective against viruses with similar cancer patients with primary breast tumors and up to 90% of mechanisms of viral entry. patients with metastatic tumors. In addition, data from our group and other groups demonstrates that Six1 is over expressed in Impact: The Project will develop a novel synthetic peptide vac- numerous additional tumor types, including, amongst others, lung, cine to prevent infection with Respiratory Syncytial Virus (RSV), ovarian, hepatocellular, and brain cancers. While initial efforts a common respiratory virus that infects children worldwide by age will be to develop drugs for breast cancer; small molecules that 2 and causes severe disease or death in infants under 6 months of inhibit the Six1 transcriptional complex may also be applied to age who have underlying lung or heart disease as well as elderly many other types of cancer. patients or adults with weak immune systems.

Investigator: Emily Gibson, Ph.D. Investigator: Malik Kahook, Ph.D.

Title: In vivo imaging of the eye using multi-photon optics for Title: Shape Memory Polymer Glaucoma Drainage Device diagnosis and monitoring of disease. Research: The project will advance preclinical testing of a novel Research: The Project objective is to construct a prototype device microsurgical implant (MSI) leveraging Shape Memory Polymer allowing multi-photon microscopy imaging of the trabecular (SMP) technology. The Project will develop a novel device to meshwork region of the human eye in vivo. This would allow maintain fluid communication between the anterior chamber of for early diagnosis and intervention to prevent vision loss from the eye and the outside of the eye to manage and reduce high eye glaucoma. pressure in glaucoma patients.

Impact: There exists a great and unmet need for technology to Impact: An alternative surgical procedure for glaucoma that is accurately diagnose glaucoma and map its progression before minimally invasive, easily reproducible, and free of serious side optic nerve damage occurs. Such an invention would increase the effects would be of great benefit to patients. effectiveness of medical intervention and prevent vision loss for millions. Investigator: Tad Koch, Ph.D.

Investigator: Todd Grazia, Ph.D. Title: In Vivo: Preclinical Evaluation of a New Therapeutic for Pancreatic Cancer Title: Autologous CD117+ Progenitor Cell Therapy in Solid Organ Transplantation and Type 1 Diabetes Research: Grant work involves preclinical experiments to establish the distribution, metabolism, toxicity, and efficacy of a Research: The project objective is to study and develop CD117 prodrug, Plasmin Activated Doxazolidine (PAD), for the treatment bone-marrow derived progenitor cells as a novel therapeutic in of pancreatic cancer. PAD may be effective against a wide variety solid organ transplantation and Type I Diabetes. of solid tumors.

Impact: These cells have high impact potential for the field of Impact: Investigators envision PAD replacing the cytotoxic com- tissue and organ transplantation as well as auto-immunity (Type ponents of current therapies for pancreatic cancer and being used I Diabetes) - as either primary therapy or adjunct therapy to in combination with a cell signaling inhibitor such as erlotinib or improve tissue/cellular engraftment, decrease acute rejection, and sorafenib. Success in treating advanced pancreatic cancer will to promote organ transplant tolerance (lack of rejection despite no stimulate investigation for the treatment of advanced solid tumors concomitant immune-suppression). of the breast, prostate, lung, and colon.

BIOSCIENCE COLORADO 2010/2011 29 Investigator: Brian Stauffer, Ph.D.

Title: Selective b1 - Adrenergic Blockade in Children with Heart Failure

Research: This project aims to provide in vivo evidence for a class of therapeutic agents that are beneficial for the treatment of heart failure in children. The purpose of the project is to determine

the ability of 3 b1 selective adrenergic receptor antagonists and a βb2 receptor agonist to prevent cardiac pathology in the animal model of pediatric disease.

Impact: The unmet clinical need underlying the proposal is the lack of evidence based medical therapy for children with heart failure. The current project will address this need by providing in vivo evidence of a class of therapeutic agents that are beneficial for the treatment of heart failure in children.

Investigator: Dan Theodorescu, Ph.D.

Title: Novel Inhibitors of Ral for the Treatment of Bladder Cancer

Research: The aim of this project is to design, synthesize, and evaluate novel second generation small-molecule inhibitors of Ral (proteins) based on lead compounds found in initial screening assays for the treatment of bladder cancer. UNIVERSITY OF DENVER

Impact: Developing a portfolio of Ral inhibitors would expedite Investigator: Siavash Pourkamali, Ph.D. the transition of these compounds from preclinical to clinical development where they will be of therapeutic benefit to lung, Title: Development of a Nanomechanical Biosensing Platform bladder, and prostate cancer patients. Research: The objective of this project is to develop, optimize and demonstrate the basis for a new biosensing platform with fully electronic readout that allows faster and simpler bioanalysis at a much lower cost. The platform will be based on the liquid phase compatible nano-electro-mechanical resonator technology that allows direct real-time measurement of the mass of the absorbed molecules eliminating the need for fluorescent labeling and optical readout setups.

Impact: This technology can potentially lead to much more cost effective and less labor intensive biodetection and medical diagnosis solutions as well as advanced and affordable instruments for molecular biology and biochemical research.

UNIVERSITY OF NORTHERN COLORADO

Investigator: Steve Mackessy, Ph.D.

Title: Toxins To Drugs: An Investigation of Colubrid Snake Ven- oms for Anticancer Compounds

Research: Identifying and evaluating novel snake venoms with high promise for potentially useful drug compounds on three dif- Pharmaceutical Research & Manufacturers of America ferent and common human cancers. Disease is our enemy. Working to save lives is our job. Impact: The research has accumulated a high number of venoms from snakes; developed an efficient workflow for processing venoms; purifying components and evaluating effects as well as moving into the next phase of drug discovery and development.

30 2010/2011 BIOSCIENCE COLORADO EARLY STAGE COMPANY AWARDS 2010-2011

2C Tech Corporation , Longmont

Development of animal models and complete formulation for phase l clinical trials of nanotechnology for the preservation of vision in patients with retinal degenerative diseases.

BioAMPS International , LLC, Aurora

Development of a peptide drug solution to the problem of bacterial resistance to conventional antibiotics.

ClariMedix Inc., Boulder

Development of a proprietary medical device technology with the ability to non-invasively trigger and modulate the production of nitric oxide to treat Alzheimer’s disease.

CytoLogic, Inc., Boulder

Commercialization of UNLEASH, CytoLogic’s novel immunotherapy aphaeresis column, for cancer treatment. COMMERCIALIZATION INFRASTRUCTURE AWARDS Mosaic Biosciences, Boulder 2010-2011

Commercialization of versatile tissue regeneration technology to Colorado Institute for Drug , Device and Diagnostic Develop- create a synthetic extracellular matrix that can be used to expedite ment (CID4) the natural healing and tissue regeneration process. The Colorado Institute for Drug, Device and Diagnostic Develop- ment funds and provides management expertise to life science dis- PeptiVir, Inc., Aurora coveries from Colorado research institutions and start-up companies through feasibility, pre IND studies, and initial clinical trials with Commercialization of a conformationally-constrained, synthetic the goal of creating viable new Colorado bioscience companies sup- peptide-based vaccine platform for the prevention of viral porting quality jobs. diseases.

CSU – Colorado Center for Drug Discovery Precision Biopsy, Aurora The Colorado Center for Drug Discovery (C2D2) fills a gap in drug- Prototyping of a proprietary fluorometer that can be utilized in discovery at Colorado research universities. The C2D2 provides clinical settings for real-time diagnosis of prostate cancer. medicinal chemistry, pharmacokinetics, and consulting resources to create new patent-protected compounds useful for validation of novel drug discovery targets and drug candidates for clinical devel- SuviCa, Inc., Boulder opment by Colorado biopharma companies and others.

Development of compounds identified in a novel screen and CU – Colorado Initiative in Molecular Biotechnology (CIMB) licensed from CU-Boulder. These compounds enhance the efficacy of standard cancer therapies and have the potential for use in the The CIMB is engaged in the construction of a state-of-the art treatment of multiple cancer types. 311,000 square foot research and education facility that links the basic sciences, engineering, clinical practice, and industry at the University of Colorado’s Boulder campus to support breakthrough developments in areas such as engineering human tissues, RNA enzyme and aptamer based pharmaceuticals, biorefining, and genetics. State grant funds will be applied to the costs of the Integrated Novel Therapeutic Discovery Center, a Sequencing Center, and costs to construct a specialized research support center.

BIOSCIENCE COLORADO 2010/2011 31 TheThe NextNext FrontierFrontier inin LifeLife SciencesSciences TheThe drive drive and and determination determination of of over over 600600 ColoradoColorado biosciencebioscience companiescompanies help help improve improve lives lives locally locally andand aroundaround thethe world.world. WhyWhy Colorado?Colorado? TheThe ability ability to to recruit recruit and and retain retain technical technical and and AA pro-business pro-business environment environment andand competitivecompetitive taxtax structure:structure: Colorado ranked 10th among the nation’s best tax scientificscientific employees: employees: Colorado ranked 10th among the nation’s best tax ColoradoColorado has has 10 10 nationally nationally recognized recognized higher higher climatesclimates for for small small businesses businesses andand entrepreneurs.entrepreneurs. education institutions and 24 federal labs. -Metro Denver EDC Bioscience Colorado Industry Cluster Profile 2011 education institutions and 24 federal labs. -Metro Denver EDC Bioscience Colorado Industry Cluster Profile 2011 Colorado ranked 1st nationally for labor supply. Colorado is 3rd among “America’s Top States for Colorado ranked 1st nationally for labor supply. Colorado is 3rd among “America’s Top States for -Forbes, 2010 Business” ranking highly for economy, business -Forbes, 2010 Business” ranking highly for economy, business friendliness, and access to capital. Colorado is the second-most highly educated state. friendliness, and access to capital. Colorado is the second-most highly educated state. -CNBC, 2010 -U.S. Census Bureau, American Community Survey, 2010 -CNBC, 2010 -U.S. Census Bureau, American Community Survey, 2010 Access to financial resources to fund research and Top metro area cities to live and work: Accessdevelopment: to financial resources to fund research and Top Denvermetro areais ranked cities #1 to where live and people work: most want to live. development: Denver is ranked #1 where people most want to live. The state passed $56 million bioscience grant program -Pew Research Center, 2009 The state passed $56 million bioscience grant program -Pew Research Center, 2009 providing funding for emerging and early stage providingcompanies funding and commercialization for emerging and infrastructure.early stage Boulder is ranked 4th nationally for “Best Cities for the Next companies and commercialization infrastructure. Boulder is ranked 4th nationally for “Best Cities for the Next Decade” for innovation and collaboration. Colorado ranks second in Small Business Innovative Decade”-Kiplinger’s, for 2010innovation and collaboration. Colorado ranks second in Small Business Innovative -Kiplinger’s, 2010 Research (SBIR) grants, third in venture capital invest- Researchments per (SBIR) $1,000 grants, for State third GDP. in venture capital invest- Affordable operating costs: ments-Toward per a More $1,000 Competitive for State Colorado, GDP. Sixth Edition, 2010 AffordableBioscience operating companies costs: can recruit affordable, productive -Toward a More Competitive Colorado, Sixth Edition, 2010 Bioscienceemployees companies as the state’s can averagerecruit affordable, wage for bioscience productive employeesworkers is as below the state’sthe national average average. wage for bioscience workers-Metro Denver is below EDC Biosciencethe national Colorado average. Industry Cluster Profile 2011 -Metro Denver EDC Bioscience Colorado Industry Cluster Profile 2011 Colorado’s average cost of living is 30% below east and Colorado’swest coast average cities. cost of living is 30% below east and west coast cities. Advocacy • Resources • Community -ACCRA Advocacy • Resources • Community -ACCRA www.CoBioScience.com www.CoBioScience.com Discovery Valley of Death Preclinical FDA Review Clinical Trials FDA Approval Market Colorado’s clinical trial landscape

By Adam Rubenstein

Companies conducting Colorado-based clinical trials include:

Abbott Abraxis BioScience Allergan Amylin Pharma Astellas Pharma AstraZeneca Biogen Idec BiPar Sciences Boehringer Ingelheim Bristol-Myers Squibb Celgene Clavis Pharma Cubist Pharma Eli Lilly olorado is home to a host of companies whose are leveraging the facilities, professionals and citizens Forest Laboratories products are undergoing clinical trials, demon- of Colorado to spearhead the world’s most innovative Genentech strating a maturing bioscience community that health-care products. GlaxoSmithKline maintains industry strengths beyond simply the Following is a snap-shot of some Colorado-based Johnson & Johnson Cdiscovery, research and development stages. The state companies who are working to advance the practice MedImmune claims a talented and dedicated work force of regula- of modern medicine through their pursuits of human tory, quality and commercially-focused profession- clinical trials: Medtronic als who are successfully shepherding quality-of-life Merck improving and lifesaving technologies through human Westminster, CO-based Allos Therapeutics (NAS- Novartis trials and placing FDA-approved products in the treat- DAQ: ALTH) has established itself as a commercial Novo Nordisk ment quiver of clinicians in the U.S. and around the organization in the oncology space as it drives sales of Ortho-McNeil world. pralatrexate in the U.S. and retains the drug’s exclusive Otsuka It is not simply the resident bioscience companies worldwide commercial rights for all indications. Based that are conducting clinical trials at a mile above sea on the results of its PROPEL clinical trial, the Company Pfizer level: There are more than 1,000 clinical trials recruit- intends to seek regulatory approval to market pralatrex- Sanofi-Aventis ing, enrolling and treating patients throughout Colorado ate in Europe for the treatment of relapsed or refrac- Schering-Plough hospitals, universities, doctors’ offices and community tory peripheral T-cell lymphoma. Allos is committed to St. Jude Medical clinics. Many of these trials are sponsored by federal evaluating pralatrexate both as a single agent and in com- Takeda agencies such as the National Institutes of Health, bination with other therapies via ongoing clinical trials. the Department of Defense, and the Department of Additional trials are planned to evaluate pralatrexate’s Wyeth Veterans Affairs. Additionally, more than 100 public potential clinical utility in other hematologic malignan- Zimmer and private pharma, biopharma and device companies cies and solid tumor indications.

BIOSCIENCE COLORADO 2010/2011 33 Clinical Pipeline: Pralatrexate pipeline is HER-family cancer patients showed that P-15™, a proprietary small peptide anorganic currently being examined in hematological ma- ARRY-543 was generally well tolerated and bone mineral. lignancies in peripheral T-cell lymphoma (Phase demonstrated evidence of tumor regression III), in cutaneous T-cell lymphoma (Phase I), and prolonged stable disease in EGFR- and Clinical Pipeline: Cerapedics is currently lymphoma (Phase II) and B-cell non-Hodgkin’s HER2-expressing cancers. A Phase Ib study enrolling patients in a Phase III clinical trial lymphoma (Phase II). The compound is also be- of ARRY-543, in combination with Xeloda, of P-15 Bone Putty for single level anterior ing examined in solid tumors in non-small cell Taxotere and Gemzar, is currently enrolling cervical discectomy and fusion procedures. lung cancer (Phase III), bladder cancer (Phase patients with solid tumors. Array contin- The trial will assess the safety and effec- II) and breast cancer (Phase II). ues a dose escalation in a Phase I trial with tiveness of P-15 Bone Putty as a substitute ARRY‑380 to evaluate a maximum, safely tol- for local autologous bone when applied in Boulder, CO-based Array Biopharma erated dose and pharmacokinetics in patients instrumented anterior cervical discectomy (NASDAQ: ARRY) is a biopharmaceutical with advanced cancer. Clinical development and fusion with use of a structural allograft company focused on the discovery, activities for ARRY-520 consist of a Phase ring in patients with degenerative cervical development and commercialization of I trial of ARRY-520 in patients with solid disc disease. targeted small molecule drugs to treat cancer tumors, a Phase I trial in patients with AML, and inflammatory diseases. The Company’s and a Phase I/II trial in patients with multiple Lousiville, CO-based GlobeImmune is a drug development pipeline includes candidates myeloma. ARRY-614 has completed a single- biopharmaceutical company focused on the designed to regulate therapeutically important and multiple-dose escalation study in healthy development of therapeutic vaccines called target proteins and those aimed at significant volunteers and initiated a Phase Ib/II trial in Tarmogens® for the treatment of cancer and unmet medical needs. In addition, a number myelodysplastic syndrome. ARRY-797 has infectious diseases. Tarmogens generate of leading pharmaceutical and biotechnology completed two Phase II trials in acute inflam- activated killer T-cells designed to locate and companies are collaborating with Array to matory pain using a dental pain model. eliminate cancer cells and/or virally infected discover and develop drug candidates across a cells. In May 2009, the company announced broad range of therapeutic areas. Westminster, CO-based Cerapedics is a global partnership with Celgene focused on a medical device company enhancing the the discovery, development and commercial- Clinical Pipeline: Phase I trials in both science of bone repair by developing and com- ization of multiple product candidates for the HER2-positive metastatic breast cancer and mercializing osteobiologic products based on treatment of cancer.

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34 2011/2012 BIOSCIENCE COLORADO Clinical Pipeline: GI-5005, in a Phase that cover new uses for an existing FDA- GSNOR knock-out have shown benefit in IIb trial for chronic hepatitis C, expresses a approved drug, Alpha-1 antitrypsin (AAT), models of respiratory (asthma and Chronic fusion protein encompassing sequences from which is currently used in the treatment of Obstructive Pulmonary Disease COPD), both HCV NS3 and Core proteins. NS3 and emphysema in AAT-deficient patients. cardiovascular (hypertension and endothelial Core, abundantly expressed in infected cells, dysfunction) and Inflammatory Bowel are required for viral replication and contain Clinical Pipeline: Initial patients have been Disease (IBD). N30’s drugs target nitric oxide targets that are recognized by both CD4+ infused in the company’s FDA-cleared Phase reductase (NOR), the most important of which helper and CD8+ killer T-cells. Both the Core I/II human clinical trial of AAT in recently is GSNOR, an enzyme of central importance and NS3 proteins are highly conserved among diagnosed Type 1 diabetics at the Barbara Davis in human health and disease. GSNOR is a HCV genotypes 1a and 1b, the HCV strains Center for Childhood Diabetes at the University selective enzyme that breaks down GSNO, the most prevalent in the U.S. GI-5005 is designed of Colorado, Denver Anschutz Medical Cam- most abundant low molecular weight source to complement both the current standard of pus. The Phase I/II clinical trial is evaluating the of the human body’s nitric oxide and is long care and emerging novel therapies for HCV. potential of AAT to halt or reduce the deteriora- known to be a potent inhibitor of inflammation. GI-4000, for mutated-Ras mediated cancers, tion of islet beta cells that causes Type 1 diabe- GSNO also positively affects vascular and causes the targeted elimination of any cell tes. While Type 1 diabetics will experience islet airway smooth muscle tone as well as control of containing mutations in the ras oncogene, and beta cell destruction, the trial evaluates whether breathing. Inhibition of GSNOR increases the is being investigated in Phase II clinical trials AAT treatment may help stop the course of the levels of endogenous GSNO. for the treatment of pancreas, non-small cell disease in newly diagnosed diabetics who may lung and colorectal cancers. have remaining islet beta cells. Clinical Pipeline: N30 announced in the fourth quarter of 2010 that it has dosed the Greenwood Village, CO-based Omni Bio Boulder, CO-based N30 Pharmaceuticals first human subject with N6022, a first-in-class Pharmaceutical’s (OTCBB: OMBP) strategy is focused on restoring nitric oxide (NO) inhibitor of GSNOR. N6022 is the lead product is to advance existing and novel therapies it balance by decreasing disease-associated in N30’s portfolio of drugs designed to treat believes have the potential to quickly move accelerated breakdown of NO’s primary asthma, COPD and IBD. The initial Phase I through clinical trials and advance to commer- depot, S-nitrosoglutathione (GSNO). To testing in healthy subjects is designed to evalu- cialization. This strategy is based on licensing date, pharmacologic inhibition in mince of ate the safety, tolerability and pharmacokinetics issued patents and pending patent applications S-nitrosoglutathione reductase (GSNOR) or of single, increasing intravenous dosages.

BIOSCIENCE COLORADO 2011/2012 35 Discovery Valley of Death Preclinical FDA Review Clinical Trials FDA Approval Market

Mile high manufacturing

By Adam Rubenstein ART

hen one thinks of a drug ing bioscience products. Specialized produc- manufacturing facility, a common ers, from independent contract manufacturers vision is of a highly automated to industry behemoths, and FDA-approved pharmaceutical production plant facilities populate the Front Range. The fol- containingW milling, micronizing and mixing lowing list includes examples of manufactur- machines that yield capsules, tablets and ing in Colorado. liquids. The production of traditional small- molecule drugs is now giving market share to Biopharma Manufacturing the rise of biopharmaceutical products such as proteins, peptides, antibodies and their Amgen (Longmont and Boulder, CO) a leading fragments. Soon these new-generation biotech human therapeutics company pioneered the de- products may very well yield market share velopment of novel products based on advances to stem cell-based regenerative therapeutics. in recombinant DNA and molecular biology. Each of these products requires unique and The Company launched the biotechnology in- highly specialized manufacturing. In addition, dustry’s first blockbuster therapeutics, Aranesp® consider the product diversity mix, diagnostic and Epogen®. Amgen LakeCentre facilities assays, the vast array of medical devices— manufacture treatments for several conditions, commercial scale manufacturing may be including chemotherapy side effects, anemia as complex and costly an endeavor as the in patients with chronic kidney disease and discovery, R&D, and clinical trial processes. osteoarthritis. LakeCentre produces Kineret® Colorado is home to manufacturers of small (anakinra) along with palifermin and other molecules, biopharmaceuticals, diagnostics pipeline product candidates in late-stage clini- and devices, and a few of the world’s best-sell- cal development, while Longmont is dedicated

36 2010/2011 BIOSCIENCE COLORADO commercial targets. The Company is focused on addressing the challenges of historically difficult-to-manufacture peptides by using their proprietary technology to minimize toxicity during bacterial growth and reduce the chemical synthesis waste stream. By enhancing yield and simplifying downstream Mile high processing, the Biopure-Process™ reduces the overall costs of development, including both materials and purification, while accom- modating the production of long, toxic and manufacturing hydrophobic peptides. CBL (Chemical and Biopharmaceutical Laboratories) (Boulder, CO) is a global peptide manufacturing technology company By Adam Rubenstein providing the industry with novel chemistries in key areas of solid phase peptide and organic synthesis. Products in the CBL catalog number in the hundreds.

Pharma Contract Manufacturing

TOLMAR (Fort Collins, CO) is a pharmaceutical R&D, manufacturing and commercial operation company that develops and manufactures both proprietary and generic pharmaceutical products in the dental, dermatology and oncology arenas. The Company has a wide variety of production capabilities, including creams, ointments, gels, solutions, liquids, injectables, and powder fill. Their production facilities include chemistry to the manufacture of Epogen (Epoetin alfa) • Fuzeon® (enfuviritde), the first in a new and microbiology laboratories, multi-shift and Aranesp (darbepoetin alfa). class of anti-HIV drugs known as fusion production operation, cGMP- and EU cGMP- inhibitors, which prevents the HIV virus compliant manufacturing, liquid, semi-solid, Merck acquired Insmed’s (Boulder, CO) from infecting healthy T-cells. The active lyophilization, and injectable filling lines as follow-on biologic candidates and their ingredient in Fuzeon is a 36-string amino well as warehouse and cold-chain distribution commercial manufacturing facilities. These acid peptide considered the most complex capability. Tolmar has 15 approved and mar- follow-on biologic candidates include INS- drug ever chemically synthesized at such a keted products. Additionally, TOLMAR has 19 and -20, recombinant forms of granu- large scale. three developed products are in active clinical locyte-colony stimulating factor (G-CSF), • Valcyte® (valganciclovir) and Cytovene® trials, five under review at the FDA, and both are currently being evaluated in Phase (ganciclovir), antiviral agents prescribed to eight products are in the development stage. I trials for their ability to prevent infections prevent and slow the spread of cytomega- Company specializations include formulation in patients with cancer receiving chemo- lovirus infection in immunocompromised and analytical development, primary package therapy, and are designed to allow for less individuals, including transplant recipients design and development, as well as IND, frequent dosing. and people with AIDS. ANDA and NDA CMC support. • Rocaltrol®, used for the treatment of bone- Roche’s (Boulder, CO) production plant reducing osteoporosis. Medical Device Manufacturing plays an important role in the pharmaceutical research, development and manufacturing Peptide Producers Baxa Corporation (Englewood, CO) was activities of its parent company, Roche of founded in 1975 with a mission to develop Basel, Switzerland. The Boulder manufactur- AmideBio (Boulder, CO) is a biotechnol- innovative products of superior quality for ing plant has provided R&D and manufactur- ogy company focused on providing peptide hospital pharmacies nationwide. In 2010, Baxa ing prowess to bring a variety of products to and protein research reagents and clinical doubled its production cleanroom space and market, some of which include: products for a diverse array of research and added assembly and warehouse space, expand-

BIOSCIENCE COLORADO 2011/2012 37 ing capacity to meet customer demand and Biotricity Medical (Aurora, CO) is a medi- designed to function for greater than 15 ensure on-time product shipments to custom- cal device research and manufacturing com- years of uninterrupted power. ers around the world. The facility features pany specializing in developing long-term 27,000 ft2 for manufacturing with an 8,000 ft2 power requirements for implanted devices C5 Medical Werks (Grand Junction, CO) ISO Class 8 (equivalent to a Class 100,000) based on bioelectric generation. The Com- serves medical manufacturers by offering cleanroom and and a 30,000 ft2 warehouse. pany is currently focused on EpiVoltTM, state-of-the-art ceramic manufacturing, Baxa products, systems and professional an implantable biogenerator that is able to materials expertise, and custom engineering services now encompass virtually every power implanted biomedical devices includ- support to prototype and commercialize their facet of compounding and dispensing fluid ing pacemakers, insulin pumps, Cochlear designs and patents. The Company focuses medications. Currently, more than 3,000 implants, artificial retinas and vagal nerve on the orthopedic, dental and spine implant hospitals worldwide use Baxa products ev- stimulators. The device creates electric- markets. ery day to produce more than 450,000 safe ity indefinitely and provides a long lasting medication doses. power source for implanted medical devices, CaridianBCT (Lakewood, CO) origins date back to 1964 when founders Bob Col- lins and Ran Bellows established COBE clinipace.com Laboratories to meet emerging needs for custom heart-lung tubing packs. COBE Laboratories evolved into a market leader in the automated blood component processing technology and medical specialty products industry. In 1990, the Company was acquired We own the technology. by Gambro, a publicly traded, multinational We adapt the process. health care company based in Sweden and in 2011 CaridianBCT was acquired by Terumo We dedicate the expertise. in 2011. The Company works to maintain its position as a leading global manufacturer and And you control it all. provider of products in apheresis collections, therapeutic apheresis, cell therapy systems, That’s the power of a dCRO. whole blood processing and pathogen reduction technologies.

Covidien (Boulder, CO) began in 1967 as Experts in Valleylab and has been a world leader in the Regulatory Consulting | Clinical Development & Operations | Data Management design, manufacturing and marketing of advanced energy-based medical systems, instruments and accessories. While the Company’s ongoing R&D is aimed at providing next generation solutions for an array of surgical and oncological challenges. Energy-based technologies harness electricity for surgi- Sprint Denver is your single source provider cal and other healthcare procedures such as for all your print communication needs. Our ablation. The Covidien team works locally to focus in producing print for the BioScience and Pharmaceutical fields means we have develop, manufacture and market innovative the resources and knowledge to help you interventional oncology solutions that focus communicate your message efficiently and primarily on ablation products. effectively to your customers. Mountainside Medical (Boulder, CO) Contact us and learn what makes Sprint Denver your best choice in print. specializes in the contract manufacturing of complex, tight tolerance medical device components and instruments. The Com- pany offers a diverse array of value-added Michael Ehrman manufacturing services with a primary core [email protected] competency in high precision machining, with a specialization in laparoscopic instru- 4999 Kingston Street, Denver, CO 80239 303.371.0566 • www.sprintdenver.com ments and jaws, orthopedic implants and instruments, product prototyping and pilot Samples and References upon request. manufacturing.

38 2011/2012 BIOSCIENCE COLORADO Discovery Valley of Death Preclinical FDA Review Clinical Trials FDA Approval Market

Changing the Lives of Patients for the Better: The True Measure of Success for Colorado’s Bioscience Industry

By Casey Demchak

n the ongoing struggle to generate being done in Colorado. These people are the work and parenting took an enormous toll on scientific breakthroughs and attract patients, and their success is the true measure the congenital pars defect in lumbar five of her venture capital and angel investors, of our success. spine, which required an L5-S1 spinal fusion. the true meaning behind Colorado’s As an emergency room nurse at Longmont Marsha also suffered from bilateral spinal bioscienceI industry sometimes gets United Hospital for 31 years, Marsha Ruggeri stenosis. Put simply, all of this translated into overlooked. However, it is never forgotten by has helped ease the pain of others through her a lot of pain. the people who feel its profound impact at the dedication to care giving. Her commitment to To decrease blood loss and achieve an very core of their lives. helping is a natural extension of the care she improved outcome, neurosurgeon Dr. Lee These are the people whose lives have has always given her 19-year-old daughter, Nelson of Boulder Neurosurgical & Spine been saved or uplifted to a much better who has a disability that has required Marsha Associates advised Marsha to have her surgery place because of the research, discovery and to lift her since she was a child. at Exempla Good Samaritan Medical Center development of drugs and medical devices Over the years the physical nature of her in Lafayette, CO. This would enable him to utilize Medtronic’s O-arm® imaging and StealthStation® navigations systems during her procedure. “Dr. Nelson used the Medtronic systems to help minimize the invasiveness of my surgery and to help assure success,” says Marsha. “He told me he could not have performed my surgery without these Medtronic devices because they made the procedure quicker, more safe and efficacious.” Having worked with Dr. Nelson in emergency room settings, Marsha felt a high level of trust when he said using the Medtronic systems would be a key to her surgery and recovery. “The end result has been quite good,” reports Marsha. “I was able to go back to work after six weeks, but I really feel I could have been back with my colleagues after four weeks had Dr. Nelson given me the go ahead.”

Marsha Ruggeri, Longmont, CO— received successful back surgery that utilized Medtronic’s O-arm® imaging and StealthStation® navigations systems.

BIOSCIENCE COLORADO 2011/2012 39 Amy Becktell of Grand Junction, CO, had progressive, bi-lateral, hereditary, sensorineural hearing loss since her late teens. In 2009 at age 53, she decided to have simultaneous bi-lateral implant surgery with the Cochlear™ Nucleus® 5 system to help improve her hearing, communication and quality of life. “I had one life before my Cochlear™ implants, and a much better life after I received them,” states Amy. “It’s that extreme. I now have a brand new life. There’s really no comparison to how much I’m understanding and how much better I feel in social situations.” Amy further states, “My Cochlear™ Nucleus® 5 implants have made a big difference at work, on the phone, and they have even improved my relationship with my husband. It feels great to know that this is now my new normal.” Amy also actively participates in the online Cochlear™ Community. “I enjoy checking in to get updates on how fellow implant recipients are doing,” she says. “It’s a great place to talk and learn about technology, and it’s also a good place for people to express emotions they might not otherwise share with Amy Becktell, Grand Junction, CO—recipient Marsha’s and Amy’s stories would not others who are not familiar with what they are of Cochlear™ Nucleus® 5 implants have been possible without the success of going through.” two Colorado companies in discovery and Her dedication to fellow implant recipients Network volunteer program. Cochlear is a commercialization. They serve as a reminder is evident by Amy’s leadership in the support very active supporter of HLAA, and today that the greatest contribution bioscience group, Hearing Loss Association of America Amy is working to get an HLAA chapter companies make is to improve the lives of (HLAA), and in the Cochlear Awareness established in Western Colorado. patients.

Division of Natural Sciences & Mathematics Offering Ph.D. and M.S. Programs in Biophysics, Biochemistry & Biology Stipend and Tuition Support Available for Competitive Applicants

For More Information on the Programs and Deadlines: www.du.edu/nsm

40 2011/2012 BIOSCIENCE COLORADO CSU Ventures Innovation at Work

From promising discoveries to innovations that change the world, CSU Ventures’ Technology Transfer and Enterprise programs provide the catalyst for growth, partnerships and new opportunities.

Simply Put, We Roll Up Our Sleeves to Move Research Innovations to Market.

First class bioscience incubation facilities and systems in CSU’s Research Innovation Center www.csuric.org

CSU Ventures, Inc. • P.O. Box 483, Fort Collins, CO 80522 • (970) 491-7100 • www.csuventures.org DIRECTORY

INDEX Accu-Tube Corporation Englewood 42 Medical Device and Related Companies www.accutube.com Manufactures standard and custom size 52 Biotechnology, Pharmaceutical and stainless steel hypodermic medical tubing.

Related Companies Actall Security Products Denver 59 Biofuels and Related Companies www.actallsp.com Engineers, manufactures and markets wireless 61 Research & Education Institutions systems for hospital and pharmaceutical company facilities. 63 Foundations Advanced MicroLabs, LLC 64 Service Providers Fort Collins www.advancedmicrolabs.com Researches and develops chemical analytical Medical Device and Related Companies AbleLink Technologies instruments in ‘Lab-on-a-chip’ format. Colorado Springs 2C Technologies www.ablelinktech.com ADA Technologies, Inc. Denver Addresses the need for well-researched Littleton Development, validation, and cognitive support technologies for individuals www.adatech.com commercialization of “SeeQ” intraocular with intellectual disabilities. Designs and manufactures prosthetic and implant as a next generation in vivo system orthotic components. for stimulating degenerated retinal cells and About Packaging Robotics restoring vision. Thornton Advanced Research Instruments www.aboutpackagingrobotics.com Corporation Abilities Unlimited Produces robotic package handling systems. Golden Colorado Springs, Denver The products are engineered to open, fill, www.aricorp.com www.auiop.com transport, seal, code and label a variety of Produces preamplifiers for PMT’s and electron Provides artificial limbs and custom orthopedic pre-made pouches and bags. Their line of multipliers, high voltage power supplies, appliances. packaging and systems for on demand product counters and timers, precision rate meters, identification are currently used in the medical, and image analyzers for scanning electron Able Planet industrial and food industries. microscopes. Wheat Ridge www.ableplanet.com Accellent Aerophase, Inc. Able Planet and its award-wining LINX Englewood, Longmont Longmont AUDIO™ are changing the lives of millions of www.accellent.com www.aerophase.com people worldwide, one customer at a time. Able Accellent is the best provider of comprehen- Research and Development of technologies Planet is developing an extensive line of audio sive supply chain solutions, and we are always that reduce environmental impact, help and communications products that are usable by striving to be more responsive to our partners. economically disadvantaged people, and people with all levels of hearing, and provide With our Accellent Focus we continue aiming at improve healthcare. Including low cost, a means whereby users can listen at lower doing just that. environmentaly friendly Meter Dose Inhaler and volumes without compromising full rich sound. iproved Aerosol Therapy for Lung Cancer. Able Customers include all people who want Accelr8 Technology Corporation access to audio and communication devices, Denver Aesthetic Technologies and with LINX AUDIO™, “It is Possible™”. www.accelr8.com Golden Able Planet is rapidly expanding its product Develops medical diagnostic technologies for www.atimed.com portfolio. Please become a member by logging research and clinical applications. The primary Manufactures and sells Parisian Peel® brand into our website, and then visit us often to see focus is rapid, integrated bacterial analysis microdermabrasion systems and accessories what’s new. system designed to identify, count, and provide along with skin care products to medical, and complete antibiotic susceptibility data by spa professionals. bacterial species within a few hours of sample injection without prior culturing.

42 2010/2011 BIOSCIENCE COLORADO Medical Device and Related Companies Aestis, Inc. Alpha Mold West Aspire Biotech, Inc. Boulder Broomfield Colorado Springs www.aestis.com www.alphamoldwest.com www.aspirebiotech.com Develops a treatment for obesity through Plastic injection mold-making facility for the Provides contract services for all phases of controlled hypoxia technology. The two medical industry. product development from concept to launch, principal components are the air separation unit and produces its own skin sealant and wound- and proprietary control system. Analytical Systems Research, Inc. closure adhesives. Aurora Agilent Technologies www.asremed.com Auri-Stim Medical Boulder Analytical Systems Research, Inc. (ASR) is Denver www.agilent.com a software development company seeking www.net1device.com Provides core electronic and bio-analytical to provide patient management tools to the Offers an alternative therapy for migraine measurement tools to advance life science practicing physician. ASR seeks to offer the headaches, hormonal migraine, chronic research. medical community a new approach to the EHR headaches, premenstrual syndrome (PMS), (Electronic Health Record) based on a web- nicotine and narcotics addictions using the AirLift Unlimited, Inc. based, point-of-care software. NET-1000 device. Evergreen www.airlift.com Animal Care Systems, Inc. A vantes Develops and manufactures soft-sided oxygen Centennial Broomfield carriers. www.animalcaresystems.com www.avantes.com Provides innovative rodent caging systems for Produces, develops and sells spectrometers, AktiVax the life-science industry. light sources, fiber optic multiplexer, fiber optic Boulder cables, software, fiber optics, accessories to the www.aktivax.com Animark, Inc. medical device industry. AktiVaxTM is developing novel reconstitution, Aurora safety syringes for vaccines and biologics. www.animark.us Bal Seal Engineering, Inc. Manufactures and sells ultrasound pregnancy Colorado Springs Allergan, Inc. detectors and ovulation predictors for livestock www.balseal.com Denver breeding. Produces seals and canted-coil springs for www.allergan.com sealing, holding, latching, and electrical contact Continually conduct research to develop Apdyne Medical Company in a variety of applications throughout the products that enable medical specialists to help Denver medical market. people preserve and protect their vision, move www.apdyne.com freely, best express their inner beauty and lead Manufactures and distributes the Apdyne Baxa Corporation healthy and active lives. Phenol Applicator Kit used to anesthetize Englewood the tympanic membrane during in-office www.baxa.com Allison Medical Inc myringotomy procedures. Develops and manufactures products Littleton for preparing, handling, packaging and www.allisonmedical.com Aqueous Biomedical administering fluid medications. Develops products to assist specialists in the Colorado Springs medical and veterinary industries, and have www.aqueousbio.com Beacon Biotechnology designed and provided essential syringes, Develops biocompatible materials and Aurora needles and custom items for various industries. geometric designs that can be applied to stents, www.beaconbiotechnology.com shunts, artificial organs and drug delivery BP Proteomics, ProLume Ltd, and Black Allogenesis LLC devices. Their first product, the Oculieve™ Forest Engineering, LLC have come together Denver shunt, is designed to control over-pressurization to create Beacon Biotechnology to pursue new www.genbiomed.com inside the eye caused by glaucoma. opportunities that build upon their respective Created purified human platelet mixture from scientific expertise. platelets contained in blood (from blood ArcScan, Inc. banks) that holds promise to replace current Morrison BeamOne, LLC growth media for stem cells. The company’s www.arcscan.com Denver pHMP product promises to offer researchers ArcScan, Inc. has developed break though www.beam-one.com more affordable animal-free option capable of imaging technology for the eye. Many Offers electron beam sterilization for medical working across applications. ophthalmologists feel its patented Artemis 3 and pharmaceutical devices. (shown above) VHF Ultrasound Arc Scanner AlloSource will change ophthalmology the way MRI Beckman Coulter Centennial changed radiology. Fort Collins www.allosource.com www.beckmancoulter.com Develops, processes and distributes life- Arcturus Star Products LLP Develops and produces instruments for the enhancing bone and tissue allografts to the Cortez diagnostic industry. Specializes in the fields medical community. www.arcturusstar.com of immunocytochemistry, flow cytometry, and Arcturus Star Products is dedicated to pioneering microbiology. AllPro Vibrational Energy Therapy for the wellness Broomfield and beauty professions. Vibrational energies www.allprodental.com incorporate subtle low frequencies of light, Produces a large selection of non-latex prophy sound, and electrical waves. Their therapeutic cups, prophy angles and other dental products. specialty is in the area of lymphatic health.

BIOSCIENCE COLORADO 2010/2011 43 Medical Device and Related Companies Bell Dental Products, LLC Boulder Innovation Group, Inc. Carsan Engineering, Inc. Englewood Boulder Golden www.belldental.com www.boulderinnovators.com www.carsaneng.com Designs, develops, and manufactures precision Develops and manufactures image-guided Designs and manufactures products for several dental equipment based on electric motor surgical navigation digitizers and industrial 3D of the leading OEMs in the medical, dental, technology. capture and modeling equipment. industrial, semiconductor, entertainment, and video projection markets. Byers Peak Braun BioSystems, Inc. WheatRidge Centennial CEA Technologies, Inc. byerspeak.com www.braunbiosystems.com Colorado Springs Leading contract manufacturer of low to Provides diagnostic point of care coagulation www.ceatechnologies.com medium volume, complex products for management systems that have a positive Provides product development and complete the medical device, biotech and industrial impact on patient outcomes in hospital, product assembly and packaging services to the instrumentation markets. outpatient, and home healthcare venues. medical industry.

BioCare Systems, Inc. Broadwest Corporation CeraPedics, Inc. Parker Denver Westminster www.biocaresystems.com www.broadwest.com www.cerapedics.com Designs, develops and markets patent- Develops and manufactures ergonomic Globally supplying the orthopedic and spinal protected, FDA cleared, new health-care devices mammography viewing equipment. communities with quality products, services and (LumiWave™) that use deep-tissue light educational opportunities to improve patient therapy to decrease pain, accelerate healing and C5 Medical Werks outcomes. improve quality of life. Grand Junction www.c5medicalwerks.com CereScan Biodesix, Inc. Offers ceramic manufacturing, materials Denver Aurora, Broomfield expertise, and custom engineering support www.cerescanimaging.com www.biodesix.com to prototype and commercialize designs and Denver-based corporation, in 2008, they Provides clinically reliable methods for the patents to orthopedic companies for hip, spinal acquired the assets and imaging database of early detection, diagnosis, therapeutic guidance, and dental implants. Brain Matters Inc., a company previously and monitoring in cancer and degenerative engaged in providing functional brain imaging diseases. Canberra Industries for almost five years. Anticipates opening 20 Greenwood Village additional centers across the nation. Bio-Logistics Preclinical, Inc. www.canberra.com Pierce Manufactures and supplies analytical Certol International, LLC www.bio-logistics.com instruments, systems and services for radiation Commerce City Offers engineering and regulatory support and detection and radiation monitoring. www.certol.com preclinical strategic development to the medical Provide patients and healthcare professionals device industry. Car-May L.L.C. with innovative products and responsible Berthoud solutions to the complicated infection control BiOptix LLC www.car-may.com challenges of the 21st century. Boulder Unlike basic metering pumps, Car-May’s www.bioptixinc.com systems provide pumping capability, fluid Clarimedix, Inc. Develops technologies to detect trace amounts measurement, and flow control all in one Boulder of bacteria, viruses, proteins, nucleic acids, compact module. www.clarimedix.com antibodies and human micro RNA’s. Develops quantum devices for the temporary Care Electronics, Inc. relief of minor muscle and joint pain, arthritis, Biotricity Medical Inc. Boulder muscle spasms and stiffness. Aurora www.medicalshoponline.com www.biotricitymedical.com Offers a range of electronic monitoring and Clean Room Devices, LLC Research and manufacturing company alarm equipment for the home health and long Westminster specializing in developing long-term power term care markets. www.cleanroomdevices.com requirements for implanted devices based on Manufactures products that are engineered bioelectric generation. CaridianBCT specifically for “clean room” environments. Lakewood BioVision Technologies, Inc. www.caridianbct.com Clifford Consulting & Research, Inc. Golden Develops and manufactures automated blood Colorado Springs www.biovisiontech.com collection systems and related information www.ccrlab.com Develops and manufactures micro-visualization systems. Developing cancer therapies and Clifford Materials Reactivity Testing (CMRT) solutions that enable endoluminal and vaccines through therapeutic apheresis and is a laboratory screening process used to help minimally invasive medical procedures in both cell therapy. Developing pathogen reduction identify existing sensitivity problems to various human and veterinary medicine. The imaging technologies. chemical groups and families of compounds in technologies and customized micro-endoscope an individual patient. This process is currently solutions are integrated to reduce incision size Caroba Plastics, Inc. being implemented in the CMRT Dental and and speed healing. Englewood Orthopedic panels. www.caroba.com Provides custom injection molds and specializes in the needs of the medical and high technology industries.

44 2010/2011 BIOSCIENCE COLORADO Medical Device and Related Companies Cobe Laboratories, Inc. CoorsTek DCS Surgical Lakewood Golden Aurora 303-232-6800 www.coorstek.com Early stage company formed to evaluate EtO (ethylene oxide) sterilization facility with Using our core strengths of custom engineering, potential new surgical procedures for the services offered to third party customers. Has materials expertise, operational excellence, and treatment of sinusitis. fulfilled requirements for EPA, FDA, ISO and rapid execution, we help our customers develop OSHA compliance. (Owned Subsidiary of amazing solutions to their toughest technical Denver Instrument Company Gambro AB) challenges. Our experienced engineering and Denver manufacturing experts are ready to help with www.denverinstrumentusa.com Cochlear Americas your next project. Designs and manufacturers analytical balances, Centennial electrochemistry instruments, moisture www.cochlearamericas.com Corgenix Medical Corporation analyzers, and titration controllers. Designs, manufactures and distributes hearing Broomfield implants including the Nucleus Freedom and www.corgenix.com Denver Optic Company Baha implants. The Colorado facility is engaged in research, Englewood development, manufacture, and marketing of www.eyeprosthetics.com ColdQuanta, Inc. in vitro diagnostic products for use in disease Specializes in the fitting and fabrication of two Boulder detection and prevention. types of ocular prosthesis. www.coldquanta.com Focuses on the development of BEC (Bose- Covidien Desert Glass Works Einstein Condensate) generating devices Boulder Colorado Springs and systems, allowing them to be accessible www.covidien.com www.dgw.com to a wide range of research, educational, Offers an extensive product line, including Manufactures quartzware for the medical and and industrial institutions. Our products are pulse oximetry and airway and temperature research industries. intended for use in scientific and industrial management devices, ventilators, vessel sealing, applications requiring high performance and and electrosurgery equipment. Die Cut Technologies reliability. Northglenn Crosstrees Medical, Inc. www.diecuttech.com Colorado Laser Technologies, Inc. Boulder Offers precision material conversion, skilled Colorado Springs www.xtreesmed.com assembly and manufacturing efficiencies, www.coloradolasermarking.com Aims to improve the quality of patient care by including cleanroom facilities. Provides YAG laser engraving technology, as developing the next generation platform for well as CO2 and YAG laser cutting services. percutaneous vertebral augmentation. Directed Energy Solutions Colorado Springs Colorado Precision Products, Inc. Cryenco/Chart Denver www.denergysolutions.com Boulder Denver Develops advanced laser and optical device www.coloradoprecision.com www.cryenco.com/ solutions for medical applications. Provides diamond turned and polished optics/ Chart Denver provides manufacturing services parts. Fabricator of X-ray telescope optical to companies who want to out-source some or DNTLworks Equipment Corporation components. Produces and offers air bearing all of their manufacturing processes, and to Centennial LVDT contact linear measurement systems, .05 companies that have capacity issues with their www.dntlworks.com microinch resolution. current manufacturing resources. Manufactures portable, mobile and self- contained dental systems. COMEG U.S.A. Endoscopy, Inc. CytoLogic Denver Commercialization of an immunotherapy device dpiX, Inc. www.comeg.de/eng for treatment of cancer. Colorado Springs A product range producing high quality video www.dpix.com imagery that meets the needs of the surgeons Darkhorse Technologies Produces high-resolution amorphous silicon (a- in terms of products, budget and services, Boulder Si) sensor arrays for medical X-ray imaging. whatever their specialty. [email protected] Commercializes a patented technology for E.I. Medical Imaging Confi-Dental Products Company affordable, hand-carried, battery operated Loveland Louisville instruments for on-site genetic detection using www.eimedical.com www.confi-dental.com Polymerase Chain Reaction (PCR). Manufacturer of highly portable and ruggedized Manufacture a wide range of dental and ultrasound devices for the veterinary industry. E.I. healthcare products including composites, DataWave Technologies Corporation Medical Imaging engineers, manufactures and cements, creams, lotions & ointments. Berthoud services these devices in Loveland, Colorado. www.dwavetech.com CONMED Electrosurgery Manufactures a wireless and battery-free Eldon James Corporation Centennial device for acquiring and transmitting data from Loveland www.conmed.com electrodes and other biosensors to a receiver www.eldonjames.com Designs and manufactures RF electrosurgical placed meters away for electrophysiology, Designs and manufactures a diverse line of generators and accessories of the highest neurophysiology and physiology related plastic and stainless steel hose fittings with a quality, safety and value for use in surgical research on both humans and large animals. single-barb design. procedures performed in virtually every hospital, surgery center and physicians office.

BIOSCIENCE COLORADO 2010/2011 45 Medical Device and Related Companies Electronic Materials, Inc. (EMI) Extreme Diagnostics Great Basin Scientific Breckenridge Boulder Longmont www.emiuv.com www.extremediagnostics.com www.gbscience.com Offers a complete line of EMCAST UV Develops noninvasive measurement systems, Technology entails an integrated disposable adhesives, epoxies, sealants, encapsulants and including optical systems such as custom cartridge containing all necessary reagents and coatings, EMI also offers room temperature, holographic and interferometric instruments. an inexpensive benchtop analyzer that executes thermal and Visible light cure adhesive systems. Specializes in structural health monitoring, the assay, interprets the results and provides nondestructive testing, and materials electronic output to the clinician that is fast, Ellab, Inc. processing. accurate, cost-effective and easy-to-use. Centennial www.ellab.com Falcon Rehabilitation Products Hach Company Manufactures thermal validation solutions for Denver Loveland food and pharmaceutical industries. www.falconrehab.net www.hach.com Designs and builds high quality, innovative Manufactures and distributes analytical Empirical Testing Corporation quadriplegic seating systems and accessories instruments and reagents used to test the quality Colorado Springs (Falcon Rehabilitation Products, LaBac Seating of water and other aqueous solutions. www.empiricaltesting.com Systems, Gel Ovations). Provides medical device testing services that HEI Advanced Medical Operations add value throughout the product development Firefly Medical, Inc. Boulder cycle, with a focus on spinal implant device Fort Collins www.heii.com testing. www.fireflymedical.com Develops and manufactures high performance Designs and develops innovative durable components, medical software, medical Encision, Inc. medical equipment for clinical healthcare devices, and non-medical products. Produces Boulder markets. microcircuits and subsystems for hearing and www.encision.com medical applications. Designs and manufactures innovative surgical Fischer Medical Technologies, Inc. devices. Developed AEM® Laparoscopic Broomfield Hirsh Precision Products, Inc. Instruments to improve electrosurgery www.fischermti.com Boulder and reduce the chance for patient injury in Designs, manufactures, and markets imaging www.hppi.com minimally invasive surgery. systems for the screening and diagnosis of Manufactures precision-machined and breast cancer. assembled components for the medical industry. EndoShape, Inc. Boulder Fluonic iBalance Medical, Inc. www.endoshape.com Boulder Boulder Manufactures surgical and medical instruments www.fluonic.com www.ibalancemedical.com focusing on shape memory polymer devices for Develops infusion therapy systems with Develops a solution for knee malalignment that endolumenal application. disposable sensors for OEM and proprietary preserves and restores natural knee surfaces. pumping systems. The Axial Knee Realignment System (AKRFX) Enplas Corporation comprises both a new surgical technique and an Colorado Springs Gambro Americas anatomic-based, knee implant system. www.enplas.com Lakewood Enplas is striving to gaze into the future through www.usa-gambro.com Illumasonix LLC “OPTPLANICS”: a new concept that fuses Develops and supplies hemodialysis, peritoneal Aurora the latest optical and electronics technologies dialysis and acute dialysis products, therapies www.alliedminds.com/Portfolio/Illumasonix/ on the basis of engineering plastics, the highly and services. index.htm functional materials that Enplas has been pursu- In partnership with Allied Minds, we will ing since its inception. GE Analytical Instruments develop and commercialize a new non-invasive Boulder vascular disease detection procedure which will Evergreen Research, Inc. www.geinstruments.com provide near real-time assessment of detailed Golden Manufactures instruments used to measure blood flow patterns within the cardiovascular www.evergreenresearch.com total organic carbon (TOC) in water for system. Offers a complete range of development services pharmaceutical applications and medical from product definition and feasibility studies research. InDevR, Inc. through detailed design to pilot-run and low- Boulder volume production to the medical device industry. Genesee BioMedical, Inc. www.indevr.net Denver Develops and manufactures biomedical Eveia Medical www.geneseebiomedical.com instruments including molecular diagnostic Boulder Manufactures cardiac surgery instruments and assays, virus measurement systems and www.eveiamedical.com devices. detection technologies for micro-arrays. Development stage company focused on creating a bioanalytical system designed Gnathodontics, Ltd. Infinity Photo-Optical Company to conduct immunassay tests. Ky attributes Lakewood Boulder include; lowfemtomolar sensitivities, short www.gnatho.com www.infinity-usa.com assay development cycles and results in Specializes in functional dentistry, advanced im- Manufactures long-distance and continuously- 10-20 minutes. The product consists of the plant work, precision partial dentures, combina- focusable microscope technology, macro instruments, software and reagents required for tion cases and metal-free fixed restorations. systems, internal-focusing devices and other analyte measurement. lenses.

46 2010/2011 BIOSCIENCE COLORADO Medical Device and Related Companies Injectech, LLC Kestrel Labs, Inc. Massively Parallel Technologies, Inc. Loveland Boulder Boulder www.injectech.net www.kestrellabs.com www.massivelyparallel.com Provides molding, assembly and design of Kestrel Labs combines internal research and Focuses on the entire communication task at medical components and fittings for OEM development projects with consulting and the cluster level, and optimize it mathematically device manufacturers. Class 100,000 cleanroom contract development of innovative, patient (22 patents granted or pending); Rigorous molding and assembly available. monitoring concepts and other medical algorithms allow a system to manage itself technologies. and adapt to changing requirements, at any Instec, Inc. scale; Libraries self-train on a given hardware Boulder Lanx, LLC configuration, so there is no tradeoff between www.instec.com Broomfield optimality and generality. Manufactures precision temperature controllers www.lanx.com and microscope hot stage systems for Specializes in systems and implants for all Mayer Medical Technologies, Inc. temperature cycling, food sciences, materials segments of spinal surgery. Integrating leading Grand Junction characterization, forensics, polymers and liquid technology, intellectual property and state-of- www.mayermedical.com crystals and microbiology. the-art engineering, each product is designed to Mayer Medical Technologies, Inc. improves simplify surgery and improve the quality of care health and saves lives by innovating new Intertek for patients worldwide by providing surgeons products, providing seed capital to medical Boulder with innovative spinal products. start-ups, and assisting medical professionals in www.intertek.com developing their product ideas. Offers testing, inspection and certification Leap Frogg, LLC of products, commodities and systems for Grand Junction mBio Diagnostics (a division of Precision medical devices. Performs FDA 510(k) reviews, 970-260-7494 Photonics Corporation) electrical safety certification including CE Created The Frogg® Dynamic Compression Boulder Marking, testing to the MDD and IVDD, risk System which Can Be Used at All Times; www.mbiodx.com analysis, EMC and performance testing. No Gaps in Protection; Reduces Accidents; Develops a low-cost, high sensitivity, multi- Reduces Nursing Time; Is More Comfortable. pathogen detection system for diagnostics. InVitria Fort Collins Leeds Precision Instruments, Inc. MedEfficiency, Inc. www.invitria.com Denver Wheat Ridge InVitria develops, manufactures and markets a www.leedsmicro.com www.medefficiency.com portfolio of high performance and well defined Offers microscopes and custom-engineered Specializes in total contact casting products for cell culture products and reagents used in products ranging from small modifications on a off-loading diabetic foot ulcers. bioprocessing, biopharmaceutical formulation, microscope stand that accommodate specific ap- stem cell & regenerative medicine, life science plications, to large specialized systems, such as an Medical Modeling, Inc. research and diagnostics. optical comparison bridge for forensic science. Golden www.medicalmodeling.com IPAX, Inc. Lenox MacLaren Surgical Instruments Produces highly accurate 3-D physical models Englewood Louisville of human bone structure from imaging such as www.ipaxinc.com www.lenoxmaclaren.com CT or MRI. Assembles and packs medical products, Manufactures precision orthopedic and focusing on bringing new medical products to neurological surgical instruments. Medivance, Inc. the marketplace. Specialty is small to medium Louisville production runs, also has the capacity and the Lexicor Medical Technology LLC www.medivance.com manpower to take on the larger jobs. Boulder Medivance® is the market leading provider of www.lexicor.com Targeted Temperature Management™ products Jorgensen Laboratories, Inc. Develops neuropsychiatric medical devices, designed to save lives, restore quality of life and Loveland such as Neba™ an experimental, small format reduce health care costs. www.jorvet.com EEG-based device being studied under an Designs and manufactures instruments which Investigational Device Exemption from the Medtronic Navigation are used in the animal health field including Food and Drug Administration. Louisville specialty instruments, surgical suture, and www.medtronicnavigation.com veterinary equipment. Lifetime Medical At the forefront of surgical navigation solu- Fort Collins tions, guiding the industry to a higher standard Kent Systems of care for several clinical specialties, includ- Loveland Logisens Corporation ing cranial neurosurgery, functional neuro- www.kentsystems.com Fort Collins surgery, spinal, ENT, joint replacement and KENT Systems designs, manufactures, and dis- www.logisens.com orthopaedic trauma surgeries. tributes Plastic Quick Couplings, Tube Fittings, Develops biosensor and software technology, and Media Bags. All our products are made in enabling a significant breakthrough in real-time Colorado! measurement and reduction of stress.

Magnelab, Inc. Longmont www.magnelab.com Manufactures custom magnetic components (transformers/inductors) for the medical field.

BIOSCIENCE COLORADO 2010/2011 47 Medical Device and Related Companies Meinhard Glass Products Mind Studios Paré Surgical, Inc. Golden Colorado Springs Centennial www.meinhard.com www.mind-studios.com www.paresurgical.com Continues the evolution in nebulizer design. A full service product design and research Develops surgical instruments such as the Quik- The principle goal is to produce finer, more studio housed within the University of Stitch endoscopic suturing system. narrowly sized-dispersed aerosols while Colorado at Colorado Springs. Offers concept maintaining the high quality, low cost and generation, advanced prototyping, engineering Parker Medical simplicity of design and operation that and consumer research, human factors design Highlands Ranch characterize the MEINHARD® nebulizer. and manufacturing solutions. www.parkermedical.com Provides airway management products that Mesa Laboratories, Inc. Mountainside Medical make intubation safer for the patient and easier Lakewood Boulder for the medical professional. www.mesalabs.com www.mountainsidemed.com Provides dialysis meters and related supplies to Specializes in the contract manufacturing of Particle Measuring Systems dialysis clinics world wide. medical device components and instruments, Boulder including electrosurgical and laparoscopic www.pmeasuring.com Metamatrix, LLC instruments and jaws, orthopedic implants, Designs, manufactures, and services precision Boulder endoscopy devices. microcontamination monitoring instrumentation www.zorbent.com and software used for detecting particles in Manufacturers of ZORBENT which absorbent nSpire Health, Inc. aerosols, liquids, slurries, gas streams and is designed to leave no residue, reducing the Longmont vacuum processing environments as well as risk associated with slippery surfaces and is www.nspirehealth.com surface molecular contamination monitoring. completely safe to use and represents no health Develops, manufactures and markets respiratory hazard. care products and services focused on PCC/Advanced Forming Technology cardiopulmonary diagnostics, respiratory core Longmont Micro Imaging Solutions, LLC (MIS) lab services, and disease management solutions. www.pcc-aft.com Englewood Offers thixoforming and metal injection www.micro-imaging.us Olympus Soft Imaging Solutions molding for the medical device industry. Developed an innovative-patented technology Corporation (OSIS) that can be utilized in the manufacture of micro- Lakewood Peak Robotics, Inc. digital CMOS cameras. www.soft-imaging.de Colorado Springs Produces, markets, and sells image acquisition www.peakrobotics.com Microlife Medical Home Solutions, Inc. and processing software and hardware for all Manufactures robots, special equipment, and Golden areas of electron microscopy. turnkey automated systems for a variety of www.mimhs.com industries including: biotech, electronics, Microlife Medical Home Solutions is Optibrand Ltd., LLC medical, semiconductor, etc. dedicated to meeting the needs of healthcare Fort Collins providers and their busy medical practices. www.optibrand.com Peddle Master, Inc. Our proprietary hand-held medical devices and Provides a fraud-resistant system to positively Johnstown systemic solutions offer healthcare providers identify animals from birth and throughout www.peddlemaster.com evidence-based and practice-tested methods for the food processing chain. The Secure Identity Designs and manufactures handicapped driving accurate assessment, diagnosis, and treatment Preservation system helps assure food safety aids. The Peddel Master is totally portable and of cardiovascular and metabolic diseases. and control the spread of animal disease. can be installed and removed in a matter of seconds. MicroPhage, Inc. OptiEnz Sensors Longmont Centennial Pernicka Corporation www.microphage.com www.optienzsensors.com Fort Collins Produces high-speed bacteria detection OptiEnz has revolutionized measurement www.pernicka.com technologies to commercialize in markets capabilities for organic chemical concentration; Offers analytical testing that meets or exceeds including: food safety, water safety, clinical now providing continuous, real-time, in-place the requirements of MIL-STD 750/883 and veterinary diagnostics and detection sensor solutions. method 1018 and 45662A for companies in applications. the semiconductor, aerospace, basic & applied Otologics, LLC research, surface analysis, thin film deposition, Mikron Corporation Denver Boulder laser technology, and medical products Aurora www.otologics.com industries. www.mikron.com Develops and commercializes surgically Supplies transfer machining systems for implantable alternatives to conventional “in the PharmaJet, Inc. complex parts, cutting tools with high ear” hearing aids. Golden performance standards, self medication and www.pharmajet.com diagnostic devices. Oval Window Audio Develops a needle-free technology that has a Nederland low cost, single use, disposable polypropylene www.ovalwindowaudio.com vial or cartridge, suitable for the delivery of Produces induction loop assistive listening common vaccines and standard dose injectable systems and visual and vibrotactile technologies liquid medicines. that help deaf and hard of hearing individuals.

48 2010/2011 BIOSCIENCE COLORADO Medical Device and Related Companies Phillips Plastics (Farley Sales Group) Precision Photonics Corporation Quest Product Development Corporation Denver Boulder Wheat Ridge www.phillipsplastics.com www.precisionphotonics.com www.quest-corp.com Phillips Plastics Corporation offers injection Provide price-competitive laser optics and Helps bring to market medical products molding from design through distribution. coatings to the telecommunications, defense, and analytical systems for small start-ups aerospace, biomedical, and semiconductor to research universities and international Physical Activity Innovations industries. corporations. Has received numerous SBIR/ Fort Collins STTR grants from NIH, DOD, NASA and 970-217-9340 Preferred Medical Products, Inc. NIST. Developing unique, footwear-based systems Englewood that motivate users to increase their daily www.preferredmedicalproducts.com Radiological Imaging Technology, Inc physical activity. Manufactures stainless steel medical Colorado Springs components for hypodermic needles and lancet www.radimage.com Pico-Tesla Magnetic Therapies, LLC type products. Provides clinical and research physicists with a Littleton high precision automated QA tool for advanced www.pico-tesla.com Prescott’s, Inc. radiation therapies. Received FDA clearance on Manufactures, markets and supports proprietary Monument RIT113 radiation therapy film dosimetry. medical device technology designed to treat the www.surgicalmicroscopes.com signs and symptoms of neurological disorders Provides reconditioned operating microscopes Rand-Scot, Inc. like Parkinson’s disease, Alzheimer’s, migraines and allied accessories that function as intended Fort Collins and epilepsy. by the original equipment manufacturer. randscot.com Designs and manufactures products for persons Plexus Corporation Probetronix, LLC with disabilities including BBD Cushions and Louisville Colorado Springs Mattress Overlays, EasyPivot Patient Lifts, and www.plexus.com www.probetronix.biz Saratoga Exercise Products. Provides integrated product development, Manufactures oscilloscope probes. manufacturing, and sustaining services of Rapid Prototying Corporation medical products. Products Group International, Inc. Longmont Lyons www.rapidpro.com PolyNEW, Inc. www.productsgroup.com Offers engineering and design and other Golden Researches, develops and engineers ultrasound manufacturing services for the medical device www.polynewinc.com medical and veterinary equipment. industry. Develops Polymer ice and methods of making and using them. Protogenic, Inc. (a division of Spectrum RJD Machining Plastics Group) Parker P orta-Lung, Inc. Westminster www.rjdmachining.com Lakewood www.protogenic.com Specializes in precision production runs and www.portalung.com Manufactures prototypes and conceptual some prototype work for OEM’s in the medical Provides non-invasive ventilator support for models using stereolithography (SLA) and industry. long-term patients who need more portability Laser Sintering (LS) rapid prototyping than the iron lung allows, while maintaining the technology. Rocky Mountain Instrument Company (RMI) same level of ventilating efficiency. Lafayette Protomed, Inc. www.rmico.com Precision Biopsy Westminster Designs and manufactures optics and coatings Aurora www.protomed.net (ultraviolet through far infrared) for the medical www.alliedminds.com/Portfolio/Precision_Biopsy/index.htm Creates accurate anatomical models from CT industry. In partnership with Allied Minds, we are scans by using the latest imaging software and working to develop and commercialize laser driven technology. Rocky Mountain Orthodontics, Inc. (RMO) technology for the accurate diagnosis Denver of prostate cancer which uses advanced Prototype Casting, Inc. www.rmortho.com spectroscopy imageing techniques in Denver Serves all areas of orthodontics including combination with tissue biopsy. www.protcast.com pediatric orthodontic prevention, interceptive Manufactures non-ferrous prototype parts pediatric orthodontics, mixed dentition Precision Diagnostic Instruments for the medical industry, specializes in RPM orthodontics, adult orthodontics, reconstructive Westminster (Rubber Plaster Mold) casting, sand casting and dentistry orthodontics, TMJ orthodontics, www.pdimeters.com rapid investment casting. surgical orthodontics and breathing/sleep Designs and manufactures professional quality, problem related orthodontics. affordable test equipment. PTA Corporation Longmont Samson Design Associates, Inc. Precision Glassblowing www.ptacorp.com Boulder Centennial Manufactures aluminum and steel molds for www.samsondesign.com www.precisionglassblowing.com projects with lifetime runs of 5,000 to 250,000 Provides full service product development Provides custom and OEM scientific glass pieces for medical applications. ranging from concept to production for custom synthesis, pharmaceutical, specifications, with many products for the environmental, petrochemical, research, medical field. commercial, government and medical laboratories.

BIOSCIENCE COLORADO 2010/2011 49 Medical Device and Related Companies Sandhill Scientific Sienco, Inc. Spectrum Laser & Technologies, Inc. Highlands Ranch Arvada Colorado Springs www.sandhillsci.com www.sienco.com www.spectrumlaser.com Designs, manufactures and distributes Manufactures and distributes Class II medical Provides contract design and manufacturing diagnostic products focused on devices, disposable supplies, reagents and services for the medical industry. gastroenterology. accessories for in-vitro diagnostic use. Also, provides tools for hemostasis monitoring and ST Cardio Technologies, LLC Securisyn Medical viscoelastic evaluations. Broomfield Littleton www.stcardio.com securisyn.com Snoasis Medical Designs, develops, and manufactures electronic Dedicated to a continuous process of increasing Denver medical devices for use in electrophysiology the safety and effectiveness of our unique www.snoasismedical.com cardiac cath labs. Our Z6 Cardiac Stimulator is life-saving product, which is utilized by skilled Develops dental regenerative products derived our first product and has FDA 510(k) clearance. medical practitioners to deliver the highest from discarded tissues and cells. quality emergency and intensive care to their St. Renatus, LLC patients. SomaLogic, Inc. Fort Collins Boulder www.st-renatus.com Science Care www.somalogic.com First needle-free, dental anesthetic suitable Aurora Uses aptamer array technology and for use in procedures involving most of the www.sciencecare.com bioinformatics capabilities to discover disease- upper teeth. Uses an accurate and sophisticated Provide human tissue for medical research and specific biomarkers and protein signatures. method to anesthetize the upper teeth without education. We serve as a link between individual Develops medical diagnostics based on these the risk and pain of a needle. donors and medical researchers and educators. signatures. StnDrd Infusion Scientech, Inc. Sonora Medical Systems, Inc. Parker Boulder Longmont www.stndrdinfusion.com www.scientech-inc.com www.4sonora.com An early-stage medical device company seeking Manufactures analytical instruments: semi- Provides high quality products and services to investors. Will participate in the drug infusion micro balances, analytical balances, semi- the diagnostic ultrasound and MRI markets. market with a standardized pump capable of analytical balances, and toploading balances for ISO 9001 certified and FDA registered. performing the product requirements currently the medical industry. met by syringe, cassette, and ambulatory pump Sontec Instruments, Inc configurations. Employs a patented valve sys- Scott Orthotic Labs, Inc. Centennial tem that enables the device to deliver from 1 to Fort Collins www.sontecinstruments.com 4 drugs sequentially, intermittently, or simulta- www.scottorthotic.com Provides a broad line of instruments as well as neously. Employs proprietary drive system with Manufactures Orthotic and Prosthetic custom instrument manufacturing and in-house dynamic volumetric delivery range from 0.1 – Components, Pre-fabricated Orthotics, and repair service. 1000 ml/ hr @ +/-5% accuracy. Custom O&P Devices. Sophono, Inc. StrionAir, Inc. Sealcon Boulder Louisville Centennial sophono.com www.strionair.com www.sealconusa.com Sophono, Inc. has developed the world’s first Manufactures and markets a product that uses Manufactures cable management components, non-percutaneous, implantable bone anchored disposable media and that can be installed in including liquid tight strain relief fittings, hearing device. any air handler or HVAC system. flexible conduit, M23 circular connectors and related products for the health care industry. Sorin Group Stroke Recovery Systems, Inc. Arvada Denver Shape Ophthalmics LLC www.sorin.com www.strokeaid.com Aurora Develops and produces cardiovascular and Develops the AutoMove AM800 that teaches Develops state of the art devices and novel autologous transfusion therapy products. healthy parts of the brain after a stroke to take treatments for ophthalmic conditions through over lost functionality. the application of advanced smart materials. Sound Surgical Technologies, LLC Louisville Summit Doppler Systems Shippert Medical Technologies Corporation www.vaser.com Golden Centennial Offers ultrasonic technologies and related www.summitdoppler.com www.shippertmedical.com techniques for aesthetic surgery. Manufactures ultrasound Doppler systems Manufactures and distributes medical used to detect fetal heartbeat and to monitor disposable products and instruments. Serves Source MDx peripheral arterial and venous blood flow. the ear, nose and throat, plastic surgery, Boulder cosmetic surgery, emergency/trauma care, www.sourcemdx.com Sunrise Medical Inc family practice, pediatric, ophthalmology and Develops RNA-based biomarkers to create Longmont dermatology fields. companion diagnostics for inflammation related www.sunrisemedical.com therapeutic areas including oncology, cardiovas- Provides home healthcare products including cular, autoimmune and infectious diseases. wheelchairs, respiratory, daily living aids, and speech augmentation devices.

50 2010/2011 BIOSCIENCE COLORADO Medical Device and Related Companies Surefire Medical Inc. TDA Research, Inc. TMJ Implants, Inc. Boulder Wheat Ridge, Golden Golden www.surefiremedical.com www.tda.com www.tmj.com The company is developing a novel infusion Provides automated catalyst testing equipment Designs and manufactures alloplastic implants system for the interventional radiology market. to large chemical companies and national for the treatment of temporomandibular joint laboratories. disorders and injuries. Supreme Cable Technologies, Inc. Thornton Tech-X Corporation Toltec International, Inc. www.supremecable.com Boulder Lakewood Manufactures quality custom cable assemblies www.txcorp.com www.toltec.biz and wire harnesses. Specializes in scientific and engineering Toltec provides medical device engineering software, including visualization and algorithm services compliant with US FDA and Swan Valley Medical, Inc. development. international regulatory standards. We Aurora assist medical device companies with the www.swanvalleymedical.com Tensegrity Prosthetics, Inc. development and maintainence of medical Swan Valley Medical has developed a line of Boulder devices in full compliance with the regulations urology instruments that allow for safer, faster, www.tensegrityprosthetics.com and standards. and more economical treatment of common Develops a prosthetic foot that mimics the urological disorders. functional biomechanics of the human foot in Touch of Life Technologies, Inc. (ToLTech) walking. Aurora The Spectranetics Corporation www.toltech.net Colorado Springs Telsano Health Develops procedural simulators in the areas of www.spectranetics.com Aurora orthopaedics, gastroenterology, rheumatology, Develops, manufactures and markets single-use www.telsano.com radiology, ophthalmology, and general surgical medical devices used in minimally invasive Telsano manufactures both the preventive health procedures. surgical procedures within the cardiovascular monitoring devices that gathers and analyzes system along with its CVX-300® excimer laser our personalized data but also provides the Transtracheal Systems, Inc. system. innovation to securely display your data and Englewood trend charts anywhere anytime. www.tto2.com Synthes, Inc. Develops and manufactures innovative Monument The Harloff Company respiratory therapy products that advance www.synthes.com Colorado Springs medical therapy for persons requiring Develops, produces and markets instruments, www.harloff.com continuous supplemental oxygen, including the implants and biomaterials for the surgical Manufactures and sells a line of crash carts, SCOOP transtracheal oxygen therapy system. fixation, correction and regeneration of the medication carts and other specialty carts for human skeleton and its soft tissues. hospitals, nursing homes, clinics and surgery Trelleborg Sealing Solutions Mountain centers. Broomfield TRS, Inc. www.trelleborg.com/en Boulder The Synaptic® Corporation Supplies high-quality products and solutions www.oandp.com/products/trs Aurora for industrial sealing and bearing systems. Develops, manufactures, and markets body- www.synapticusa.com Activities are focused in many business powered prosthetic devices. Designs and builds Develops Synaptic®, a patented pain control areas including the food and pharmaceutical technology for persons missing hands. technology that works without drugs. Marketed industries, as well as medical engineering. in accordance with FDA regulations for the Tapeless Wound Care Products, LLC treatment of acute and chronic pain. Ultrathera Technologies, Inc. Englewood Colorado Springs www.tapelesswoundcare.com TheraTogs, Inc. www.ultrathera.com Manufactures and distributes a system of Telluride Life sciences company dedicated to improving patented secondary wound dressing retention www.theratogs.com human performance by applying advanced devices, offering an alternative to traditional Produces an orthotic undergarment and technologies to physiological and neurological secondary wound dressings, for both human strapping system that gives clients with needs. Maker of AeroStim™ and PointScribe™. and animals. sensorimotor impairment a new modality for improving postural alignment and stability. Value Plastics, Inc. T artan Orthopedics, Ltd Fort Collins Northglenn Tissue Genetics, Inc. www.valueplastics.com www.tartanortho.com Aurora Designs and manufactures plastic tubing fittings Manufactures sacro lumbar belts, dorsal lumbar www.tissuegenetics.com and connectors. belts (corsets and moldable inserts), Ottenberg Molecular diagnostics company with unique style elbow splint, pelvic traction belts, arm technology for improving the care of patients V alveXchange, Inc. slings, cervical collars, acromioclavicular with genetic diseases using biomarkers to Aurora splints, and ankle supports. identify patients with hereditary diseases and to www.valvexchange.com determine the course of care. Develops a bioprosthetic heart valve with a percutaneously-exchangeable leaflet set that provides lifetime service without anti- coagulation therapy.

BIOSCIENCE COLORADO 2010/2011 51 BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES Vista LifeSciences Zetek, Inc. Albany Molecular Research, Inc (AMRI) Parker Aurora Denver www.vistalifesciences.com www.zetek.net www.amriglobal.com Innovative Healthcare Technology Solutions for Manufactures the OvaCue family of ovulation Performs services including drug discovery, Global Healthcare Challenges. prediction products. pharmaceutical development, and manufacturing of active ingredients and VitruMed, Inc. Zynex Medical, Inc. pharmaceutical intermediates for many of the Boulder Lone Tree world’s leading healthcare companies. www.vitrumed.com www.zynexmed.com Focused on the development of a minimally- Offers electrotherapy products, utilizing various Allergan, Inc. invasive radio frequency (RF) tissue welding methods of non-invasive muscle stimulation Denver technology for pulmonary resections including andelectromyography technology, Interferential www.allergan.com biopsies, to further advance early detection and Current (IFC) and Transcutaneous Electrical Multi-specialty health care company focused on treatment of lung cancer. Nerve Stimulation (TENS). discovering, developing and commercializing innovative pharmaceuticals, biologics, medical WalkMed Infusion, LLC devices and over-the-counter consumer Englewood products. www.walkmed.net BIOTECHNOLOGY, PHARMA, AND RELATED Offers solutions for ambulatory infusion COMPANIES Allos Therapeutics, Inc. therapy and pain management. Westminster www.allos.com WV A i Company Accera, Inc. Develops and commercializes small molecule Boulder Broomfield therapeutics for the treatment of cancer. www.ewavi.com www.accerapharma.com The platform is based on the Electroencepha- Discovers and develops breakthroughs in Alpharma, Inc. lograph (EEG) that integrates with physician treating central nervous system disorders, Longmont diagnostic tools and a research library. Helps focusing on serious and difficult-to-diagnose www.alpharma.com with interpretation and treatment of brain ail- neurodegenerative diseases, products includes Alpharma’s field-proven feed additives and ments and performance including TBI, PTSD, therapeutic treatments for Parkinson’s disease, water solubles help prevent or treat common Alzheimer’s Age Management and depression. Alzheimer’s disease and other age-related deficiencies and diseases in cattle, swine, and memory loss disorders. poultry that may negatively affect their health. WestMed, Inc. Greenwood Village Accuthera, Inc. American Allied Biochemical, Inc. www.westmedinc.com Denver Aurora Designs, manufacturers and markets medical www.accutherainc.com www.aablabs.com devices to anesthesia and respiratory Develops therapeutics for acute and critical care Specializes in the purification and distribution professionals. indications. Initial clinical indication is acute of restriction endonucleases enzymes. lung injury caused by trauma and/or serious Westone Laboratories infectious pathogens. Amgen, Inc. Colorado Springs Boulder www.westone.com Advanced Regenerative Therapies (ART) www.amgen.com Designs and manufactures custom earmolds for Fort Collins Amgen Discovers, develops, manufactures and hearing healthcare and other applications. www.art4dvm.com markets human therapeutics based on advances Provides a stem cell isolation and expansion in cellular and molecular biology. Amgen’s Wi LLC – Medical Device Product service for veterinary medicine. operations in Colorado are dedicated to the mis- Development sion of assuring patient supply and creating a Englewood Agilent Technologies world-class capability for rapid commercializa- www.wiinc.net Boulder tion, launch and transfer of bulk biopharmaceu- Designs and engineers medical devices. www.agilent.com tical products. In addition to licensed manufac- Including innovative services such as laser Agilent Nucleic Acid Solutions develops and turing of EPOGEN, NPlate, XGEVA, Prolia and welding, assay design, and air bubble manufactures therapeutic oligonucleotide in a clinical therapeutics, Amgen Colorado pursues management. multi-product, 33,500 square foot facility. strategic contract manufacturing opportunities.

Ximedix, Inc. Agripro COKER AmideBio, LLC Colorado Springs Berthoud Boulder www.ximedix.com www.agriprowheat.com www.amidebio.com Manufactures and sells single patient use Develops and delivers superior wheat seed Focused on providing peptide and protein medical products for the anesthesia, respiratory genetics in North America. research reagents and clinical products for care, critical care and emergency medicine a diverse array of research and commercial applications. AKTIV-DRY targets using proprietary Biopure-Process™ Boulder technology. Yamato Corporation www.aktiv-dry.com Colorado Springs Provides dry powder processing solutions for www.yamatocorp.com the vaccine, pharmaceutical, and biotechnology Manufactures and sells weighing equipment and industries. systems for medical facilities.

52 2010/2011 BIOSCIENCE COLORADO BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES Ampio Pharmaceuticals, Inc. ASDx Biosystems, Inc. bioNovo Greenwood Village Boulder Aurora ampiopharma.com www.asdxbio.com www.bionovo.com Develops innovative proprietary drugs for Specializes in the development of immunoassays Discovers and develops drugs for women’s metabolic disease, eye disease, kidney disease, for environmental agents, foodborne pathogens, health, including menopause, osteoporosis and inflammation, sexual dysfunction and CNS infectious diseases and oncology biomarkers cancer. disease. using luminescence detection technologies and dedicated luminometer instrument systems. BioResponse, LLC Anabolic Laboratories Boulder Colorado Springs AspenBio Pharma, Inc. www.bioresponse.com www.anaboliclabs.com Castle Rock Researches, develops and commercializes Focused line of nutritional products, with www.aspenbioinc.com dietary supplements for better absorption and state-of-the-art pharmaceutical manufacturing Primarily focused on advancing towards com- functional foods. facilities in California and Colorado. mercialization, our recently patented blood-based human diagnostic test, AppyScore™ to aid in BioServe Space Technologies Animal Health Options the diagnosis of human appendicitis and several Boulder Golden novel reproduction drugs for use in high value www.colorado.edu/engineering/BioServe www.animalhealthoptions.com animals. Researches space life science with a wide Animal Health Options has been offering high range of biotechnology applications involving quality antioxidants and nutritional supplements Astellas Pharma US, Inc. animals, plants and microorganisms. that meet or exceed industry standards and pro- Denver Specializing in conducting microgravity life vide a noticeable benefit to dogs, cats and horses. www.astellas.us science research and designing and developing Researches and develops pharmaceuticals for space flight hardware. ApopLogic Pharmaceuticals, LLC select theraputic areas, including Urology, Aurora Immunology, Dermatology, Cardiology, and Biosyntrx Inc. www.apoplogic.com Infectious Diseases. Colorado Springs Focused on the development and www.biosyntrx.com commercialization of Breceptin, a unique Aurogen Develops nutraceuticals to address the oncolytic drug for the treatment of a wide range Fort Collins micronutrient needs of the dry eye, cataract, of solid tumors. www.aurogen.com macular degeneration, glaucoma and diabetic Produces a pharmaceutical treatment for retinopathy patient. Aquatic BioSystems diabetic neuropathy, with a second invention Fort Collins showing that neurotrophic hormones can act B ioVantage Resources, Inc. www.aquaticbiosystems.com across the blood-brain barrier (BBB) to treat Golden Full-service organism culturing facility special- various brain disorders. www.biovantageresources.com izing in the production and distribution of Delivers algae-based bioremediation solutions freshwater and marine organisms for aquatic A vidity, LLC for municipal, industrial and agricultural toxicology, biomonitoring and other research Aurora wastewater treatment. activities. www.avidity.com Licenses the patented biotin-accepting peptides BodySync, Inc. ARCA biopharma, Inc. (AviTag) technology which exploits the tight Aurora Broomfield, Aurora interaction of avidin or streptavidin with biotin www.bodysync.com www.arcabiopharma.com for immobilizing, purifying and visualizing Applies evidence-based genetic information Specializes in developing and commercializing proteins. to develop personalized products that help genetically-targeted therapies for heart failure individuals achieve their health goals. and other cardiovascular diseases. BaroFold, Inc. BodySync, Inc. purchased some of Sciona’s Aurora assets recently. Ariel Pharmaceuticals www.barofold.com Broomfield Discovers, develops and commercializes protein Bolder BioPATH, Inc. www.arielpharma.com biologics. The pipeline contains therapeutics Boulder We are a specialty pharmaceuticals company with an immunology focus, including Multiple www.bolderbiopath.com focused on developing therapeutic products Sclerosis, Rheumatoid Arthritis, and Asthma. Contract pathology and pharmacology research that will greatly improve the lives of people company that specializes in inflammatory with orphan diseases and acute conditions of BioAMPS International, LLC disease models with emphasis on models of neurological origin. Aurora arthritis. www.bioamps.com Array BioPharma Focused on the discovery, development and Bolder BioTechnology, Inc. Boulder, Longmont commercialization of proprietary antimicrobial Boulder www.arraybiopharma.com peptide (AMPS) therapeutic solutions for the www.bolderbio.com Discovers, develops and commercializes tar- treatment of systemic infectious diseases, Uses advanced protein engineering technologies geted small molecule drugs to treat debilitating including methicillin-resistant Staphylococcus to create proprietary human protein and life-threatening diseases such as cancer. aureus (MRSA) and other resistant gram- pharmaceuticals with enhanced therapeutic negative and gram positive bacteria. properties.

BIOSCIENCE COLORADO 2010/2011 53 BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES Boulder Scientific Company Cell>Point Cobax Biopharma, Inc. Mead Centennial Louisville www.bouldersci.com www.cellpointweb.com www.cobaxbiopharma.com Provides organometallic compounds to the Develops novel radiopharmaceutical imag- Cobax is developing a novel bacteriotherapy pharmaceutical, polymer, and specialty ing agents, radiotherapeutic agents and local to prevent recurrence of Clostridium difficile- chemical industries. regional radio/chemotherapeutic drug delivery associated disease (CDAD) by re-establishing systems for the diagnosis, treatment and post the normal gastrointestinal (GI) flora. Recurrent Brotica therapy asessment of cancer, cardiovascular dis- CDAD is a major unmet medical need where Bellvue ease, infectious disease and metabolic diseases. bacteriotherapy is proven to be efficacious. www.interval33.com We are seeking financing to support the Produces Interval33, a termite attractant which Ceragenix Pharmaceuticals, Inc. development of a prototype product. works by producing the precise level of CO2 Denver that has been shown to attract termites, all www.ceragenix.com Colorado Biolabs, Inc. natural and animal safe. Engages in the discovery, development and Frederick commercialization of a portfolio of innovative www.proferrin.com Cargill Research products for dermatolog and infectious disease Colorado Biolabs, Inc., the manufacturer of Fort Collins applications. Proferrin® ES and Proferrin® Forte, was www.cargill.com founded in 1997 with a plan to develop and Develops, processes and markets science-based, Cévan International, Inc. market Proferrin – an oral iron supplement health promoting ingredients for food and Longmont made from heme iron polypeptide (HIP). Our dietary supplement industries worldwide. www.cevan.com proprietary process results in an oral iron Delivers vitamins, minerals and botanical product that provides an optimal amount of HIP CaridianBCT Biotechnologies, LLC extracts as well as specialty nutriceutical in a single tablet. Lakewood formulations and antioxidants. www.caridianbct.com Colorado Genetics, Inc. Develops techniques to improve safety of the CHATA Biosystems Loveland blood supply by reducing the pathogens found Fort Collins www.coloradogenetics.com in donated blood. www.chatasolutions.com Provides livestock embryo-transfer research, Manufactures blended reagents, HPLC mobile artificial insemination, embryo collection, Catalent Pharma Solutions, Inc. phases, standards, buffers and dissolution freezing and transfer, and international import Boulder media. and export services. www.catalent.com Designs, manufactures and distributes Chemizon Inc. Colorado Histo-Prep (CH-P) specialized medical products for fluid Longmont Fort Collins management of pleural effusion and ascites. www.chemizon.com www.histoprep.com Focused on the discovery and development of Produces high quality slides, clinical chemistry Caveo Therapeutics targeted therapies to treat patients afflicted with and hematology data and fully integrated and Aurora cancer, inflammatory and metabolic diseases. detailed seamless pathology reports. www.caveotherapeutics.com Discovers and develops innovative Cinpathogen, Inc. Colorado Serum Company biopharmaceuticals to treat and cure Boulder Denver hematologic conditions. Provides two research www.cinpathogen.com www.colorado-serum.com reagents, highly specific monoclonal antibodies International research company devoted to Supplies veterinary biologic vaccines, to the Mer receptor tyrosine kinase. improving the understanding and diagnosis of instruments, laboratory reagents and serums for diseases in China. the veterinary industry. CBL Biopharma LLC (Chemical and Biopharmaceutical Laboratories) ClinImmune Labs Crestone, Inc. Boulder Aurora Aurora www.cblbiopharma.com www.clinimmune.com www.crestonepharma.com Offering peptide starting materials, peptide Provides genetic testing for transplant patients Drug discovery and development company intermediates, and industrial and commercial- in addition to stem cell processing and focused on developing novel treatments for scale manufacturing of proprietary and generic umbilical cord blood banking. serious bacterial infections. The company GMP and non-GMP peptides. currently has two advanced pre-clinical Clovis Oncology, Inc. programs that address areas of significant and Cedarburg Hauser Boulder growing unmet medical need, both with novel Denver www.clovisoncology.com mechanism of action agents. www.cedarburghauser.com Clovis Oncology is a biopharmaceutical Contract development and manufacturing company focused on acquiring, developing and Cytoskeleton, Inc. company for active pharmaceutical ingredi- commercializing innovative anti-cancer agents Denver ents (API) and pharmaceutical intermediates in the US, Europe and additional international www.cytoskeleton.com that combines the benefits of working with a markets. Offers kits for drug screening, signal contract research organization (CRO) and a transduction and cytoskeletal research contract manufacturing organization. specializing in the production of purified proteins and easy-to-use kits to study biochemical and cellular processes.

54 2010/2011 BIOSCIENCE COLORADO BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES DaVita FluTrends International, LLC Gonex Inc. Lakewood Denver Fort Collins www.davita.com www.flutrends.com www.cedusinc.com DaVita provides a complete range of dialysis Biotechnology company that plans to develop Dedicated to the research, development treatments and support services for patients and commercialize products for the prevention and commercialization of hormonal based living with chronic kidney failure. of influenza. health care strategies for both the human and companion animal markets including DiscoveRx GEL Analytics, LLC technology for sterilizing companion animals Fremont, CA Golden with a single injection. www.discoverrx.com www.gel.com DiscoveRx® is a fast growing innovative Offers expertise in the field of mass GlaxoSmithKline company that develops, manufactures, and spectrometry and provides chemistry, Denver commercializes reagents, complete assay radiochemistry, radiobioassay and bioanalytical www.gsk.com kits, and turn key solutions for the drug analysis. Produces medicines that treat six major disease discovery, screening, and life science markets. areas – asthma, virus control, infections, mental Our products, biochemical and cell-based Gene Check, Inc. health, diabetes and digestive conditions as well assays, enable customers to improve research Greeley as vaccines and new treatments for cancer. productivity and effectiveness, thus accelerating www.genecheck.com the discovery and development of new drugs. Gene Check is a diagnostic laboratory GlobeImmune, Inc. specializing in veterinary genetics. In addition, Louisville Eckstein Diagnostics Gene Check maintains a dynamic biotech www.globeimmune.com Fort Collins research program, including rare DNA sequence Discovers, develops and manufactures potent, www.rmi2.org/57/Eckstein%20Diagnostics and SNP detection. targeted molecular immunotherapies called Developing techniques to directly and indirectly Tarmogens, targeted antigens that distinguish detect pathogens from tissues and fluids through Genentech diseased cells from normal cells, for the various methods. Denver treatment of cancer and infectious diseases. www.gene.com Efficas, Inc. Using human genetic information to discover, Greffex, Inc. Boulder develop, manufacture and commercialize Aurora www.efficas.com medicines to treat patients with serious or life- www.greffex.com Develops bioactive products that offer natural threatening medical conditions. Develops and produces new therapeutics for relief from asthma and allergies in both humans immune suppression in humans to prevent and animals. Genesis Laboratories, Inc. transplant rejection, improve gene therapy and Wellington develop novel approaches to the treatment of ELISA Tech www.genesislabs.com autoimmune diseases. Aurora Provides services to clients in the agrochemical www.elisatech.com and pharmaceutical industries, rodenticide Hauser Laboratories, Division of Microbac Provides immunoassays for the measurement research and development, as well as invasive Boulder of cytokines, growth factors, and lipid species, zoonotic disease, and conservation www.hauserlabs.com inflammatory mediators such as prostaglandins research. Provides research, development, and testing to and leukotrienes. the pharmaceutical, natural products, dietary GeneThera, Inc. supplement, and medical device industries. Evolutionary Genomics (EG) Arvada Lafayette www.genethera.net HemoGenix® www.evolgen.com Develops and markets the latest molecular Colorado Springs Identifies genes with a high likelihood of technologies to eradicate “cross over” diseases www.hemogenix.com commercial value for downstream validation such as Johne’s Disease, Mad Cow Disease, Private contract research service and assay through their proprietary Adapted Traits Chronic Wasting Disease, and E.coli. Develops development laboratory specializing in platform. assay tests and vaccines to radicate the threat developing predictive in vitro assay platforms to humans of diseases transmitted up the food for primary human and animal target cells and Feiger Health Research Center (FHRC) chain by cattle, elk and deer. stem cell hemotoxicity testing. Wheatridge www.feigerresearch.com Genetic Technologies Limited HepQuant, LLC Private research facility specifically focused on Fort Collins Aurora clinical trials for medication to treat depression. www.gtglabs.com www.hepquant.com Uses the latest technology to identify changes in Designed test parameters using continuous vari- FlashBack Technologies DNA to either confirm a diagnosis of a specific ables that may be correlated to clinical features Longmont disorder of which a person displays signs or or may be followed over time to measure dis- www.flashbacktechnologies.com symptoms, or to identify individuals at risk ease progression. HepQuant-E is non-invasive, Fast, non-invasive detection of acute blood of developing a disease before any symptoms uses stable (not radioactive) isotopes, and relies loss volume and prediction of cardiovascular appear. on natural, well-defined hepatic functions to collapse in emergency situations. measure the portal circulation.

BIOSCIENCE COLORADO 2010/2011 55 BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES Heska Corporation iPDx Biosciences, Inc. Loveland Boulder expert testing www.heska.com www.ipdxbio.com innovative technologies Develops advanced diagnostics and specialty Develops and markets multiplexed service with results products for veterinary practices that focus on immunoassay and proteomic test systems companion animals. and applications for the decentralized and point-of-care personalized diagnostic market. Hiberna Corporation Clinical applications will focus on autoimmune, Boulder metabolic, oncology and neurodegenerative www.hibernapharma.com disorders. Pursuing the potential clinical application of 855.522.7878 hibernation in order to slow metabolism thereby Isogenis, Inc. www.labs-inc.org extending survival limits in traumas that reduce Aurora denver • st. louis • philadelphia oxygen to certain cells, e.g. in the heart and www.isogenis.com brain. Develops therapies for organ transplantation and genetic disease with products based on the LABS, Inc. Hospira, Inc. veto effect which occurs when specific T-cells Denver Boulder programmed to destroy a transplant are all www.labs-inc.org www.hospira.com permanently inhibited. Provides laboratory testing services focused Supplies injectably generic and specialty on donor eligibiligy determination and final pharmaceuticals. The Colorado site specializes Johnson & Johnson product safety; infectious disease, microbiology, in the supply of active pharmaceutical Denver histocompatibility and environmental ingredients for both internal and external www.jnj.com monitoring. markets. Manufactures a broad selection of health care products, as well as a provider of related Legacy BioDesign, LLC ICVrx services, for the consumer, pharmaceutical, and Johnstown Aurora medical devices and diagnostics markets. www.LegacyBioDesign.com www.icvrx.com Conducts peptide and protein formulation Drug reformulations and delivery systems tar- Keen Ingredients, Inc. and assay development work for biopharma geting disorders of the central nervous system. Louisville companies. The company also specializes in www.keeningredients.com drug delivery and process development of IHCtech, LLC Develops process to de-bitter and stabilize biotechnology-based products. Aurora quinoa naturally. Supplying the natural and www.ihctech.net gluten free industries with high quality Quinoa Life BioScience Inc. Offers custom histopathology services, ingredients. Longmont antibodies, probes and biosensors tested in www.lifebioscience.com tissue. Specializes in immunohistochemistry Keeton Industries, Inc. Developed a patent pending glass-ceramic and in situ hybridization. Wellington material that is photo-structurable. We fabricate www.keetonaqua.com 3D glass and ceramic micro-arrays for protein, imuTek Laboratories, Inc. Researches and develops biological water DNA, glycan, peptides and carbohydrates. Fort Collins treatment, aeration, ozone aeration, solids We also produce and sell printed microarrays. www.imutek.com removal, biofiltration and other new Out other products revolve around cell based Develops and markets bovine colostrums for technologies. assay and multiplexed micro sphere platforms the nutrition and health products industry. The utilizing our glass-ceramic material. first manufacturer to receive an indication for Kimball Genetics, Inc. colostrum for the passive transfer of antibodies Denver LifeTime Pharmaceuticals, Inc. (immunoglobulins) in dry powder form. www.kimballgenetics.com Aurora Genetic testing laboratory specializing in DNA LifeTime is developing several classes of Institute for Therapeutic Biology analysis for common genetic disorders that are small molecules that stimulate production and Denver preventable or can be treated. function of WBCs. www.therapeuticbiology.org Research organization studying the Role of KromaTid, Inc. Light Labs T-Cell maturation in Immunology. Fort Collins Aurora www.kromatid.com www.lightlabsusa.com InViragen, Inc. Develops a method and kit using chromatid Light Labs distributes, PCR tubes, TPP tissue Fort Collins paints to improve detection of chromosomal culture, pipette tips, microcentrifuge tubes, www.inviragen.com inversions. The improvement is important to barrier tips, latex gloves, PCR supplies, and Focused on developing life-saving vaccines to medical applications such as cancer and birth much more. protect against emerging infectious diseases defects. worldwide. Inviragen’s lead product is a vaccine Lohocla Research Corporation to protect against dengue fever. Aurora www.lohocla.com Develops diagnostics and therapeutics focused on pain, psychiatric and addictive disorders such as alcoholism, depression, smoking cessation and chronic pain.

56 2010/2011 BIOSCIENCE COLORADO BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES MacLeod Pharmaceuticals, Inc. Mitomics Inc Oberon FMR Fort Collins Aurora Idaho Springs www.macleodpharma.com mitomicsinc.com www.oberonfmr.com Develops and manufactures anti-bacterial Mitomics is pioneering the development of Early stage company with proprietary pharmaceuticals for the veterinary industry. molecular tests based on the mitochondrial technology capable of producing a cost- genome in order to improve clinical insight effective, sustainably produced protein Martek Biosciences Corporation and therapeutic decisions that affect patients meal. Oberon’s product serves as a fish meal Boulder worldwide. replacement (FMR) or additive ingredient for www.martek.com animal feeds, primarily those destined for the Develops, manufactures and sells products Molecular BioSciences, Inc. aquaculture industry. from microalgae. Products include nutritional Boulder supplements and food ingredients which play www.molbio.com Omni Bio Pharmaceutical, Inc. a role in promoting mental and cardiovascular Manufactures products such as water soluble Greenwood Village health. biotinylation reagents, vitamin derivatives, www.omnibiopharma.com crosslinking reagents, lipophilic probes, Advancing broad-spectrum therapeutics MBC Pharma, Inc. fluorophores, radioiodination reagents, and targeting bacterial and viral diseases, Aurora dendritic cores for preparing oligomers. biohazards, diabetes and transplant rejection. www.mbcpharma.com Biopharmaceutical company focused on Monsanto Company OncoTherix discovering and developing drugs for bone Boulder, Denver, Lakewood Aurora diseases such as cancer and osteoporosis. www.monsanto.com www.oncotherix.com Develops technology to produce healthier Clinical stage oncology company focused on MedImmune, LLC foods, better animal feeds and more fiber, the development of InCell-RT (Intracellular Denver while reducing agriculture’s impact on our radiotherapy) for the treatment of locally- www.medimmune.com environment. Products lines include seeds and advanced cancers (LACs). InCell-RT is Strives to provide better medicines to patients, traits and agricultural productivity. a unique, DNA-ligated, nanometer-scale new medical options for physicians, and intracellular radiotherapy with the potential rewarding careers to employees. Mosaic Biosciences to selectively kill cancer cells without Denver causing damage to surrounding healthy tissue Mediral International, Inc. mosaicbio.com and without the development of treatment Denver Commercialization of versatile tissue regenera- resistance. www.mediral.com tion technology to create a synthetic extracel- Develops, manufactures and sells homeopathic lular matrix that can be used to expedite the OPX Bioechnologies pharmaceuticals taking into consideration natural healing and tissue regeneration process. Boulder antidotes. www.opxbiotechnologies.com N30 Pharmaceuticals, LLC Technology platform enables rapid, rational, MenoGeniX Boulder and robust optimization of microbes and Aurora www.n30pharma.com bioprocesses to manufacture bioproducts www.menogenix.com N30 Pharma’s drugs target nitric oxide with equivalent performance and improved Clinical stage biotechnology company focused reductase (NOR), the most important of which sustainability at lower cost compared to on the development of an approved drug, is s-nitrosoglutathione reductase (GSNOR) an petroleum-based alternatives. in a new indication, menopause, and the enzyme of central importance in human health menopause-like symptoms that occur in certain and disease. OSI Pharmaceuticals breast and prostate cancer patients. Boulder Novartis Pharmaceuticals Corporation www.osip.com Merck & Co., Inc. Broomfield Develops and commercializes high-quality and Denver www.novartis.com novel pharmaceutical products for patients with www.merck.com Researches and develops products to protect cancer, diabetes, and obesity. Merck and Co. produces products that cover and improve health and well-being with core a broad range of areas, including heart and businesses in pharmaceuticals, vaccines, Pambec Laboratories, Inc. respiratory health, infectious diseases, sun consumer health, generics, eye care and animal Loveland care and women’s health. And they focus their health. [email protected] research on conditions that affect millions Researches drug discoveries in the field of of people around the world – diseases like Novus Biologicals, Inc. AIDS. Alzheimer’s, diabetes and cancer – while Littleton building strengths in new areas like biologics. www.novusbio.com Paragon Analytics Develops, tests and markets antibodies for Fort Collins miRagen Therapeutics research of human diseases such as cancer, www.paragonlabs.com Boulder cardiovascular and neurological disorders. Environmental and radiochemistry testing www.miragentherapeutics.com laboratory offering radiochemistry, mixed Improves patients’ lives by developing Nutraceutix, Inc. waste, explosives, organics, metals, and general innovative microRNA (miRNA) based Lafayette chemistry analyses. Division of DataChem therapeutics for the treatment of cardiovascular www.nutraceutix.net Laboratories, Inc. and muscle disease. miRNAs, are a recently Offers probiotic organisms (powders) and discovered class of small RNAs encoded in finished probiotic supplements. Specializes the genome, are short, single-stranded RNA in custom crafting dietary supplements with molecules. advanced delivery technologies.

BIOSCIENCE COLORADO 2010/2011 57 BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES Peak Analytical, Inc. Regenerative Sciences Inc. Sandoz Golden Broomfield Broomfield www.peaklab.net www.regenexx.com www.us.sandoz.com Specializes in materials and chemical analysis. Advances stem cell therapies through Focuses on pharmaceuticals, consumer Performs a variety of molecular and atomic development of Regenexx™, an injection health, generics, eye care and animal health. level spectroscopic techniques to identify procedure to treat a wide variety of painful Therapeutic categories inlcude anti-infectives, failures and defects. conditions. anti-arthritics, cardiovasculars, gastrointestinal agents & psychotherapeutics. PeptiVir Roche Colorado Aurora Boulder Sharklet Technologies, Inc. site.peptivir.com www.rochecolorado.com Centennial PeptiVir is an early stage biopharmaceutical Develops manufacturing processes for complex www.sharklet.com company focused on the development and pharmaceutical compounds in the Colorado Engineers surface technologies (Sharklet™) commercialization of a conformationally- manufacturing facility, a resource for small to that controls the growth of dangerous bacteria. constrained, synthetic peptide-based vaccine large-scale peptide manufacturing. platform for the prevention of viral diseases. Siva Therapeutics Inc Rocky Mountain Biosystems, Inc. Boulder Pfizer Pharmaceutical Company Wheatridge www.sivatherapeutics.com Centennial Develops a tissue sealing technology that Commercialize a proprietary therapeutic device www.pfizer.com activates a specially formulated adhesive technology, based on gold nanorods, that Discovers, develops, manufactures, and markets to bond tissue and achieve a uniform seal can be used both independently, and also in prescription medicines for humans and animals. in seconds. The systems temporarily or conjunction with existing and new cancer drugs. permanently modify tissues for transdermal and PhosphoSolutions, LLC deposition drug delivery, and for cosmetic skin Solutions Biologic Aurora resurfacing. Boulder www.phosphosolutions.com Consulting firm providing strategic planning, Designs and produces phosphoproteins Rocky Mountain Diagnostics, Inc. technical and project management services solutions using phosphor-specific antibodies. Colorado Springs to biopharmaceutical companies. Support Phosphoproteins are thought to be critical www.rmdiagnostics.com development and commercialization of products elements in neurological diseases such as Provides immunodiagnostic assays and reagents from preclinical to marketed stages. Alzheimer’s and in cancer. for biogenic amines, research reagents, a CLIA certified reference laboratory and contract STA Laboratories, Inc. Pisces Molecular manufacturing services. Longmont Boulder www.stalabs.com www.pisces-molecular.com Rocky Mountain Instrumental Agricultural product testing laboratory that Applies molecular biology to problems in the Laboratories offers seed quality, genomics, plant health and aquatic environment. Fort Collins diagnostic services and products. www.rockylab.com Pyxant Labs, Inc. Provides contract chromatographic and mass Summit Plant Laboratories, Inc. Colorado Springs spectrometric analysis of pharmaceuticals Fort Collins www.pyxant.com (both traditional drugs and biotechnology www.plantlabs.com Specializes in GLP bioanalytical chemistry products, such as proteins and peptides and Applies laboratory plant cloning and greenhouse development support for life sciences clients. oligonucleotides), veterinary and human technologies to produce planting stocks for endocrinology, and forensic toxicology. breeders, greenhouses, and field crop producers. Qgenta Aurora Rocky Mountain Reagents, Inc. SuviCa, Inc. 720-859-4045 Golden Boulder Harnessing innovative chemistry and biology in www.rmreagents.com Suvica will use mutant fruit flies to screen for the development of molecular targeted agents Manufactures stains, culture media and new cancer treatments. for the treatment of cancer. chemistry solutions for the medical industry, as well as titration reagents, indicators, acids, Taiga Biotechnologies, Inc. Quark Pharmaceuticals, Inc. bases, and a variety of chemicals for industrial Aurora Boulder uses. www.taigabiotech.com www.quarkpharma.com Develops cellular, biologic and small molecule Discovers and develops siRNA drug candidates RST Bioscience LLC approaches to treat hematological diseases, for treating Age-related Macular Degeneration Aurora including cancers, immunodeficiencies and and prevention of Acute Renal Failure. Develop and commercialize assay system to autoimmune conditions. monitor astronauts for viral infection during Reckitt Benckiser (RB) space flight. Thermo Fisher Scientific Fort Collins Lafayette www.rb.com Saigene Biotech Inc. www.thermofisher.com Fastest-growing companies in household, health Monument Scientific leadership and innovation in RNAi, and personal care products. www.saigene.com Gene Expression, qPCR/PCR Detection, and Commercializing Sandwich Hybridization Molecular Biology technologies come together Assay technology for the testing of Harmful with the Thermo Scientific Dharmacon, Algae Blooms in conjunction with the Open Biosystems, ABgene, Finnzymes, and Monterey Bay Aquarium Research Institute and Fermentas product lines to provide world- Stanford University. leading solutions for gene analysis.

58 2010/2011 BIOSCIENCE COLORADO BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES TOLMAR, Inc. Vitro Diagnostics, Inc. ZeoponiX, Inc. Fort Collins Golden Boulder www.tolmar.com www.vitrodiag.com www.zeoponix.com Develops and manufactures both proprietary Develops and commercializes products derived Develops NASA originated technology to and generic pharmaceutical products with from human cell line research with a focus produce a soil amendment/fertilizer zeoponic specific focus in therapeutic areas of dental, predominantly in stem cell R&D related to material that utilizes nutrients more efficiently dermatology, and oncology. numerous diseases such as heart disease, stroke, and reduces nutrient leaching into the Parkinson’s and Alzheimer’s disease. environment. Upsher-Smith Laboratories, Inc. Denver Vitrolife, Inc. ZooPharm, Inc. www.upsher-smith.com Englewood Fort Collins Develops, manufactures and markets a vast www.vitrolife.com www.zoopharm.net range of prescription and over-the-counter Develops, manufactures and sells products Specialized veterinary compounding pharmacy. products for cardiology, dermatology, women’s and systems for the preparation, cultivation We custom compound analgesics, sedatives, health and other areas. and storage of human cells, tissue and organs. their antagonists, and other unique drugs for use Product areas include fertility, transplantation in veterinary medicine. US Pharmacal Company, Inc. and stem cell cultivation. Erie www.uspharmacal.com VRL Laboratories Researches, develops and sells topical Centennial BIOFUELS AND RELATED COMPANIES pharmaceuticals for the geriatric community. www.vrl.net Laboratory offers full service regulated donor Ventria Bioscience eligibility testing for the human cell and tissue A1 Organics Fort Collins community. Eaton www.ventria.com www.a1organics.com Develops a protein expression technology Warren Analytical Laboratory Composts and recycles organic by-products platform called ExpressTec with a product Greeley from various waste: yard trimmings, wood, pipeline in human nutrition and therapeutics. www.warrenlab.com biocides, agricultural by-products, manure, Specializes in food microbiology, molecular brewery by-products, construction debris and Ventrus Biosciences, Inc. biology, food chemistry, residue chemistry and food residuals. Greenwood Village nutritional labeling. www.ventrusbio.com A2BE Carbon Capture, LLC (algae@work) A specialty pharmaceutical company Western States Biopharmaceuticals, Inc. Boulder focused on the late-stage development and Aurora www.algaeatwork.com commercialization of gastroenterology www.westernstatesbiopharm.com developing bio-secure, scalable, climate products. Novel anti-inflammatory therapeutics for adaptive, and highly cost effective technology autoimmune diseases. for producing valuable fuel and food from CO2 Verdant BioSciences Corporation using algal photosynthesis and bio-harvesting. Denver What’s Going Round, LLC www.verdantbio.com Aurora Aerophase, Inc. Develops plant biochemical regulators that www.WhatsGoingRound.com Longmont provide superior plant performance and unlock Healthcare IT company whose goal is to www.aerophase.com the productive power of plants in markets from become the place where you go first when Research and Development of technologies floriculture to industrial agriculture. you’re thinking about your health. that reduce environmental impact, and efficient extraction system for biodiesel VetDC Wildlife Pharmaceuticals, Inc. Fort Collins Fort Collins BBI International www.vet-dc.com www.wildpharm.com Lakewood VetDC (Veterinary Emerging Technologies Providing pharmaceuticals for the safe and www.bbibiofuels.com Development Corporation) is a for-profit humane care of non-domestic and exotic Offers consulting services, including feasibility company focused on development of novel wildlife species. studies, market analyses, site & resource devices, diagnostics and therapeutics for assessments, economic impact studies, business emerging veterinary markets. With unmet YewSavin, Inc. plans, industry benchmarking and industry medical needs in many areas of veterinary Fort Collins surveys to the biofuels sector. medicine, VetDC is positioned to leverage www.ajorganica.com the expertise of the CSU Veterinary Teaching Develops chemical and biochemical BioEnergy of Colorado, LLC Hospital and the CSU Research Foundation to technologies. Successfully finished multi- Denver license existing technologies from the human step syntheses using Bromination, Grignard www.bioenergycolorado.com market and develop the technologies for the reaction, Suzuki coupling, Amidation, and Produces biofuel alternatives utilizing Soy animal market, including proof of concept, Esterification reactions. Biodiesel from virgin soy oil. Current product pre-clinical and clinical work. VetDC will line includes Biodiesel (Gold and Green™) and then out-license the validated technologies BioHeat. to large animal health companies for commercialization.

BIOSCIENCE COLORADO 2010/2011 59 BIOFUELS AND RELATED COMPANIES BioFuel Energy Corporation Community Power Corporation Merrick® & Company Denver Littleton Aurora, Colorado Springs www.bfenergy.com www.gocpc.com www.merrick.com Constructs large scale ethanol production Develops, commercializes and markets Provides engineering, construction facilities in cooperation with Cargill and owns modular biopower systems to meet the needs management, and development services for and operates two of the largest dry mill ethanol of distributed energy consumers in both biomass conversion-to-ethanol projects, also facilities in the United States. developing and developed countries. providing consulting services to oil and gas clients and local regulated utilities. BioLynceus Biological Solutions Delta Dynamics, LLC Estes Park Denver Novo Energy LLC www.biolynceusturf.com www.deltadynamicsenergy.com Fort Collins Working to help local governments, businesses Constructs and installs small-scale biomass www.novoenergyllc.com and citizens to use environmentally safe alterna- plants. Colorado-based renewable energy company that tives to harsh toxic chemicals. Our Biological provides state-of-the-art technology, equipment, Solutions renew the natural ecological system Front Range Energy, LLC and project support services for the renewable with biologically sound products that do not Windsor energy and solid waste disposal industries. contaminate soil or water resources. www.frontrangeenergy.com Ethanol producer since 2006. Will process Nuemann Systems Group Biomass Energy Foundation (BEF) approx. 40 million gallons of ethanol and Colorado Springs Franktown 396,000 tons of wet distillers’ grain annually. www.neumannsystemsgroup.com www.woodgas.com Research, technology and product development Researches alternative fuels such as dried fruit GeoSynFuels, LLC focused on product prototyping of gas-liquid pits, vegetable oil, wood, coffee grounds and the Golden contactor systems for chemical processing and methods to produce biofuels. www.geosynfuels.com emissions control. Developsd a low-cost method to convert Blue Sun Biodiesel cellulosic biomass into fuel. The technology PolyNEW, Inc. Golden uses biological mechanisms set in a solid-state Golden www.gobluesun.com fermenter (“SSF”) to convert the biomass into www.polynewinc.com Distributes premium agricultural and renewable ethanol and/or methane. Developed a new class of PLA bioplastics fuel products. Blue Sun Fusion™ a blend which it terms “ecobionanocomposites.” These of premium Blue Sun Biodiesel (20%) with Gevo, Inc. are nanocomposites from 100% renewable petroleum diesel fuel (80%), along with Englewood resources that could be used in a wide variety proprietary additive package specifically www.gevo.com of applications including medical device tailored for regional climates and seasons, is Develops advanced biofuels like isobutanol, applications. available at numerous retail pumps throughout butanol that will provide a sustainable path to Colorado, Wyoming, New Mexico, Nebraska, the replacement of petrochemicals like gasoline, Power Ecalene Fuels, Inc. Utah, and Idaho. diesel and jet fuel. Arvada powerecalene.com Colorado Center for Biorefining and H2OPE Biofuels, Inc. Exclusive licensor of a patented nano-catalyst Biofuels (C2B2) Aurora technology that efficiently converts “syngas” or Boulder www.h2opebiofuels.com “producer gas” into a premium mixed alcohol www.c2b2web.org H2OPE Biofuels will provide a clean alternative transportation fuel called Ecalene™. Ecalene™ A cooperative research and educational center source of fuel for the masses, available is usable as a stand-alone fuel for cars, trucks, devoted to the conversion of biomass to fuels globally using an affordable, readily available buses, jet aircraft and boats. and other products. Works to establish ground- photosynthetic process. The product is a green, breaking research and educational programs alternative source of fuel, utilizing algae to PureVision Technology, Inc. for the advancement of renewable energy produce hydrogen. Fort Lupton technologies. www.purevisiontechnology.com Intermountain CHP Center Develops a carbon-neutral biomass CH2M Hill Boulder fractionation technology that converts cellulosic Englewood www.intermountainCHP.org biomass into sugars, energy and fiber that www.ch2m.com Formed by the U.S. Department of Energy to are bio-based raw materials to make many One of the world’s leading firms in the design increase adoption of Combined heat and power industrial and consumer products. of biochemical and biofuels facilities. Provides (CHP) in the states of Arizona, Colorado, New engineering, procurement, construction, Mexico, Utah, and Wyoming. Range Fuels management, consulting and sustaining services Broomfield for biochemicals, ethanol, cellulosic ethanol, LUCA Technologies, Inc. www.rangefuels.com and biodiesel plants. Golden Converts biomass that cannot be used for www.lucatechnologies.com food into low carbon biofuels and clean Ciris Energy, Inc. Researches the ability of naturally occurring renewable energy using emerging clean energy Centennial microorganisms to convert under-utilized technologies. Biomass includes all plant and www.cirisenergy.com domestic oil, organic-rich shale and coal plant-derived material, such as wood, switch Formed to develop, commercialize and produce resources to clean, renewable energy. grass, corn stover, and miscanthus grass – clean energy from abundant, low-value carbon making it a renewable energy resource that sources, on a large scale. We are practical produces no net greenhouse gases. technology implementers, and primarily an energy production company.

60 2010/2011 BIOSCIENCE COLORADO RESEARCH AND EDUCATION San Juan Bioenergy Aims Community College Colorado Center for Drug Discovery (C2D2) Dove Creek Greeley, Loveland, Fort Lupton Fort Collins www.sanjuanbio.com www.aims.edu c2d2.org Pressed oil seed facility in the heart of a One of the largest and most comprehensive A non-profit organization funded through the developing oil seed region. two-year colleges in Colorado, offering more State of Colorado. The organization promotes than 160 degree and certificate programs. Since drug discovery research with Colorado through Solix Biofuels, Inc. 1967 Aims has established four campuses, a combination of funding, medicinal chemistry Fort Collins constructed 18 buildings, expanded curriculum and modeling expertise. www.solixbiofuels.com to 2,000 day, evening and weekend courses and Develops massively scaleable photo-bioreactors taught more than 300,000 students. CPC Clinical Research for the production of biodiesel and other Denver valuable bio-commodities from algae oil. AMC Cancer Research Center www.cpcmed.org Denver Revolutionizing clinical research and creating Sterling Ethanol, LLC www.amc.org innovative preventative programs that will Sterling AMC is a national, not for profit research change behavior to improve your health. www.sterlingethanol.com institute dedicated to the prevention and control Produces 42 million gallons of ethanol annually, of cancer and other chronic diseases. AMC is Colorado School of Mines using the distiller’s grain produced as a co- conducting innovative and important research Golden product of ethanol to the areas cattle feeders for in the areas of cancer causation and prevention, www.mines.edu its high protein levels. behavioral research, nutrition, clinical and A public research university internationally community studies and health communication. recognized for its leadership in engineering, Sundrop Fuels, Inc. applied science and related disciplines, with a Louisville Biological Sciences Curriculum Study (BSCS) special emphasis on the Earth and its resources. www.sundropfuels.com Colorado Springs These programs, with strong interdisciplinary A solar gasification-based renewable energy www.bscs.org linkages across the campus, have led to the company. A nonprofit corporation that endeavors integration of bioscience and biotechnology to improve all students’ understanding into educational and scholarly activities. CSM ZeaChem of science and technology by developing has created a Bioengineering and Life Science Lakewood exemplary curricular materials, supporting Program that draws upon faculty and students www.zeachem.com their widespread and effective use, providing from all of the academic units. Developed a cellulose-based biorefinery professional development, and conducting platform capable of producing third-generation research and evaluation studies. Colorado State University ethanol fuel and intermediate chemicals. Our Fort Collins, Pueblo indirect approach leapfrogs the yield and Bonfils Blood Center www.colostate.edu carbon dioxide (CO2) problems associated Denver As one of the nation’s leading research with traditional and cellulosic based ethanol www.bonfils.org universities, Colorado State University processes. One of the nation’s leading community blood is committed to realizing its vision as a centers through their commitment to quality 21st century land-grant university. CSU service, innovation, research and technology. leads the world in such areas as infectious They offer a full range of blood products disease research, atmospheric science and RESEARCH AND EDUCATION and services to healthcare partners including environmental science. Its faculty members supplying rare blood units or helping to are tackling such issues as the reemergence of determine the best cross-matched unit to endure tuberculosis, the brown cloud of air pollution Advanced Diagnostic Laboratories (Adx) the best possible patient outcomes. in Asian cities, severe weather forecasting, at National Jewish Medical and Research nutrition and wellness, and bioterrorism. In Center Centers for Disease Control and addition to its excellent programs in those areas, Denver Prevention/Division of Vector-Borne CSU offers among the very best professional www.njlabs.org Infectious Disease programs in the United States in areas like Adx offers cost-effective and timely pre- Fort Collins veterinary medicine, occupational therapy, clinical, clinical and non-clinical trials and www.cdc.gov/ncidod/dvbid journalism, agriculture and construction helps customers select, customize, perform, The Division of Vector-Borne Infectious management. Its programs in the arts, interpret and report clinical tests. Their Diseases (DVBID) is part of the U.S. Centers humanities and social sciences are also reference laboratory provides solutions for for Disease Control and Prevention (CDC). outstanding. the rapid development of custom assays, CDC is the lead federal agency for protecting consultation, clinical strategy assessments and the health and safety of people at home and CSU Research Innovation Center innovation within the areas of the National abroad. DVBID serves as a national and Fort Collins Jewish expertise. ADx operates under GLP international reference center for vector-borne csuric.org guidelines when applicable and the laboratories viral and bacterial diseases, such as West Nile The Research Innovation Center (RIC) are fully accredited by the College of American virus, Lyme disease, plague, tularemia, yellow serves as a vehicle to perform collaborative Pathologists (CAP) and the Clinical Laboratory fever and dengue. It coordinates national translational-stage research with CSU’s life Improvement Act (CLIA), as well as others. disease monitoring activities, conducts field sciences community of researchers, giving it the and laboratory research, responds to epidemic promise to become the birthplace of medical situations, develops strategies for disease breakthroughs. prevention and control, provides diagnostic reference and epidemiologic consultation, and conducts technical assistance and professional training activities.

BIOSCIENCE COLORADO 2010/2011 61 RESEARCH AND EDUCATION Community College of Aurora (CCA) nationwide. DSST: Stapleton has consistently impact of its research papers in the fields of Aurora been the highest performing secondary school Molecular Biology, Genetics, and Biology www.ccaurora.edu in DPS, based on growth and absolute perfor- and Biochemistry. NJC manages a technology CCA provides lifelong educational mance. DSST: Stapleton’s first four graduating portfolio of more than 100 investors. opportunities, prepares the current and future classes earned 100% acceptances into four-year workforce, and promotes excellence in colleges. Fifty percent of DSST’s 2010 graduat- National Renewable Energy Laboratory teaching, learning and service. CCA offers a ing class is first generation college-bound. Golden unique Biotechnology Technician Research www.nrel.gov and Development Certificate designed to train Front Range Community College The nation’s primary laboratory for renewable highly skilled lab personnel for the biotech Brighton, Fort Collins, Longmont and Westminster energy and energy efficiency research and industry. www.frontrange.edu development (R&D). NREL’s mission and Front Range Community College, Colorado’s strategy are focused on advancing the U.S. Colorado Initiative in Molecular largest community college, provides instruction, Department of Energy’s and our nation’s Biotechnology (CIMB) in both general education and occupational energy goals. NREL’s R&D areas of expertise Boulder areas, which may lead to a certificate, an are: renewable electricity (solar, wind, cimb.colorado.edu associate degree, or transfer to a four-year biomass, geothermal), renewable fuels State-of-the art research and education facility institution. The college also provides college (biomass, hydrogen), integrated energy system that links the basic sciences, engineering, preparatory education, non-credit instruction engineering and testing (buildings, electric clinical practice, and industry at the University for personal and professional development, systems and transportation infrastructures), and of Colorado’s Boulder campus. and workplace skill development. With strategic development and analysis (economic, campuses located in Fort Collins, Longmont financial, and market analysis, planning and Colorado Institute for Drug, Device and and Westminster, the college is proud of its portfolio prioritization). Diagnostic Development (CID4) many partnerships to provide quality programs Aurora that are responsive to the needs of its local Poudre Valley Health System www.cid4.com communities. Loveland, Fort Collins CID4 provides management expertise to www.pvhs.org efficiently transform emerging life science Keystone Symposia on Molecular and Poudre Valley Health System operates as a technologies into commercial successes. We Cellular Biology private, not-for-profit organization providing do this by identifying and funding potential Silverthorne a regional network of health care services opportunities, and by utilizing an advanced www.keystonesymposia.org for the people of northern Colorado, western leadership team to ensure speed to market, A non-profit organization that serves as a Nebraska, and southern Wyoming. The system putting new products and services to work catalyst for the advancement of biomedical and is comprised of the Poudre Valley Hospital, where they are needed. life sciences by connecting scientists within and the Medical Center of the Rockies, as well as across disciplines at conferences and workshops several community clinics that provide primary Denver Museum of Nature and Science held at venues that create an environment and specialized medical services. Poudre Valley Denver conducive to information exchange, generation Hospital was named one of the nation’s top 100 www.dmns.org of new ideas, and acceleration of applications hospitals for the fifth year, has been considered The Denver Museum of Nature & Science is that benefit society. a Magnet Nursing Practice since 2000 and the Rocky Mountain region’s leading resource has been presented with the American Nurses for informal science education. A variety of National Institute of Standards and Association’s highest award for sustained exhibitions, programs, and activities help Mu- Technology (NIST) overall excellence in nursing quality. seum visitors experience the natural wonders of Boulder Colorado, Earth, and the universe. www.nist.gov Regis University NIST is a non-regulatory federal agency that Denver DSST Public Schools (Denver School of operates eight different science and advanced www.regis.edu Science and Technology) technology research divisions in Colorado. The School of Pharmacy aspires to be the Denver NIST’s list of research accomplishments foremost school of pharmacy in the United www.dsstpublicschools.org includes a NIST senior scientist winning the States where students are nurtured and DSST Public Schools is dedicated to provid- Nobel Prize in 2001 for creating the world’s first developed to become leaders in pharmacy ing a diverse student body with an outstand- “Bose-Einstein condensate.” In 2003 another practice, research, education, and public service. ing liberal arts high school education with a NIST scientist won a MacArthur Fellowship for As a result, students graduate as professionals science and technology focus. By creating a discovering a new quantum gas and was named who are knowledgeable, skillful, and principled, powerful learning community centered on core by Science as one of the top ten scientific and who are able to make a positive impact on values and a shared commitment to academic advances of the year. the dramatically changing role of pharmacists excellence, DSST will increase the number of in our transforming society. They are educated underrepresented students (women, minorities National Jewish Health to be committed to excellence in healthcare, and economically disadvantaged) who attain Denver evidenced not only by their knowledge and college science and liberal arts degrees. DSST www.njc.org abilities, but also by their quality of care, Public Schools operates three schools on two The number one respiratory hospital in integrity, compassion, respect, advocacy, campuses, Stapleton (grades 6-12) and Green the U.S., is also one of the most influential initiative, service and leadership. To achieve Valley Ranch (6th). A third DSST campus, independent biomedical research centers in these goals, faculty members are dedicated to Cole Arts and Sciences, will open with a 6th the world. More than 100 faculty members providing innovative practice models, exploring grade in the fall of 2011. DSST: Stapleton is conduct basic, translational, and clinical novel applications of basic and clinical research, widely considered to be one of the leading open research in immunology, respiratory medicine, and illustrating the value of lifelong learning. enrollment STEM schools (Science, Technol- allergy, cancer, and cell and molecular biology. ogy, Engineering and Mathematics) in the U.S. NJC ranks among the top ten percent of and has become a destination for educators all institutions for NIH support and for the

62 2010/2011 BIOSCIENCE COLORADO RESEARCH AND EDUCATION Rocky Mountain Innosphere logical Information Infrastructure (NBII). This is search studies in the creation of new knowledge Fort Collins the first comprehensive electronic gateway dedi- and leading edge biotechnologies to improve www.rmi2.org cated exclusively to biological science data and quality of life for a worldwide community. At Rocky Mountain Innosphere (RMI), we information from sources throughout the world. are helping new clean energy, technology and University of Northern Colorado scientific startup companies turn their great ideas Greeley into great businesses. These businesses, in turn, www.unco.edu create high wage job opportunities for the com- University of Northern Colorado (UNC) is a munity and fuel the growth of the industries of multipurpose institution with a wide range of the future. graduate and undergraduate programs. The university’s mission is to prepare individuals Rocky Vista University College of Osteo- for advanced study, professional careers, and pathic Medicine (RVUCOM ) positions of leadership. Denver Rocky Vista University College of Osteopathic Work, Education and Lifelong Learning Medicine (RVUCOM ) is one of the newest of Simulation (WELLS) Center the 28 colleges of osteopathic medicine currently Aurora established or in development in the United www.wellssimulationcenter.org States. With five departments – biomedical University of Colorado For the first time in Colorado, one facility offers sciences, structural medicine, primary care, Boulder, Denver, Aurora, Colorado Springs a complete array of state-of-the-art patient Osteopathic Principles and Practices, Specialty www.cu.edu simulation tools for building clinical knowledge. Medicine and Medical Informatics the faculty The University of Colorado System’s 52,000 Even more exciting, high-speed datacasting and staff of RVUCOM are committed to osteo- students and 28,000 faculty and staff contribute technology makes this unique resource available pathic philosophy and heritage, and to advancing to every facet of life in Colorado. The state’s eco- remotely. Students, faculty and practicing nurses the science and the art of the practice of osteo- nomic vitality, educated workforce, entrepreneur- and physicians from throughout Colorado can pathic medicine. ial climate, cultural capital, health care delivery, enhance their diagnostic and clinical skills at and scientific explorations all rely on the driving the WELLS Center either on-site or on-line. Rose Medical Center force of a vigorous state university. By working Housed in the new Bioscience East building Denver with other CU academic and research units, as at Fitzsimons, the WELLS Center represents www.rosemed.com well as local, state, and federal funding agencies, a unique collaboration among educators, Has earned a reputation as Denver’s “Baby Hos- commercial business, and nonprofit organiza- providers and policymakers. pital” while becoming a leader in comprehensive tions, CU is creating a collaborative synergy in women’s services, internal medicine, endoscopy, important areas that will better the wellness of heart and vascular care, orthopedics and total society. The CU Institute of Bioenergetics, the FOUNDATIONS joint replacement, bariatric surgery, sports medi- Colorado Initiative in Molecular Biotechnology, cine and aesthetic surgery. the Center for Computational Biology, and the Center for Pharmaceutical Biotechnology attract Boettcher Foundation Scientific Education & Research Institute intellectual strength to Colorado, provide new Denver (SERI) educational opportunities, and inspire innovative www.boettcherfoundation.com Thornton health care advances. Research and teach- Founded by the Boettcher Family in 1937 to www.theseri.com ing hospitals affiliated with the University of effectively assist, encourage and promote quality SERI is a unique institute, which combines an Colorado include: The University of Colorado of life for the citizens of Colorado, the Boettcher orthopedic clinic, specializing in spine surgery, Hospital, The Children’s Hospital, National Jew- Foundation invests in education, community with a clinical research unit and and education ish Medical and Research Center, Denver Health services, health, and arts & culture through merit and training program. Our facility has available and the VA Medical Center. awards, scholarships and capital grants. to rent an amphitheater with full AV setup for presentations, as well as a bioskills lab with ca- University of Denver Colorado State University Research daveric dissection capabilities. We host a variety Denver Foundation (CSURF) of educational programs including summer sci- www.du.edu Fort Collins ence camps. Additionally we host a large number Strives to provide the most modern educational www.csurf.org of training programs sponsored by surgical and and research facilities in the life sciences. Their CSURF is a private, not-for-profit Colorado medical companies. history spans the Denver Research Institute’s Corporation established (in 1941) to aid and development of the first NASA life monitoring assist the University campuses (Colorado Swedish Medical Center sensors, the establishment of a state-of-the-art State University and recently Colorado State Englewood forensics laboratory, to the 2003 acquisition of University Pueblo) governed by the Board of www.swedishhospital.com the Eleanor Roosevelt Institute with pioneering Governors of the Colorado State University Level I Trauma Center, serves as the region’s re- efforts in genomics and bioinformatics. In 2004, System in their research and educational ferral center for neurotrauma and is a recognized the School of Engineering and Computer Science efforts. Functions include patent and licensing leader in the treatment of stroke. An acute care unveiled Colorado’s first undergraduate program management; equipment leasing and municipal hospital with 368 licensed beds. in Bioinformatics and a master’s degree in Bioen- lease administration; financing of equipment, gineering. The interdisciplinary mission of the real estate and buildings through mortgage debt United States Geological Survey (USGS) - University enabled the Department of Biology obligation(s); and land acquisition, development Center for Biological Informatics to launch new emphases in Bioengineering, Bio- and management. Denver physics and Cognitive Neuroscience designed for biology.usgs.gov/cbi molecular biology majors. In addition to strong The Center for Biological Informatics, at the and quality curricula, bioengineering and life sci- Denver Federal Center, operates the national Bio- ences at DU carry multimillion-dollar-a-year re-

BIOSCIENCE COLORADO 2010/2011 63 FOUNDATIONS The Children’s Hospital Foundation CRB Engineers and Builders Consulting - Regulatory, Aurora www.crbusa.com Commercialization and Development www.imaginethemiracles.org The Children’s Hospital Foundation is the Facility Planning Arts fundraising arm for TCH programs and www.planningartsinc.com Aerie Bioconsulting, LLC operations. Since 1978, the Foundation has aeriebioconsulting.net raised more than $200 million for the hospital The Neenan Company LLP and today is in the middle of a fudnraising www.neenan.com Biologics Consulting Group, Inc. campaign to financially support the building www.biologicsconsulting.com of a new hospital at Fitzsimons, as well as The Whiting-Turner Contracting Co. Children’s programs and services. www.whiting-turner.com Emerson Consultants, Inc. www.emersonconsultants.com Poudre Valley Health System Foundation Loveland, Fort Collins Consulting - General Business Evergreen Research, Inc. www.foundation.pvhs.org www.evergreenresearch.com The Poudre Valley Health System Foundation Biomedical Communication & Consulting philanthropically supports and promotes the [email protected] Evolve Biosciences LLC health interests of Poudre Valley Hospital, www.evolvebiosciences.com the Medical Center of the Rockies and the Fitzsimons BioBusiness Partners (FBBP) community by raising and distributing funds www.fbbp.org Grow Emerging Companies LLC for programs that target prevention, education, www.grow-ec.com research, health promotion, wellness and LCC Consulting, LLC disease management. www.lccconsulting.net Health Perls, LTD.

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