2013-2014

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13_0280 Colorado BioScience Ad.indd 1 2/21/2013 12:39:53 PM TABLE OF CONTENTS

Welcome to the Colorado BioScience Association’s tenth anniversary edition of Bioscience Colorado, 10 years of supporting the the state’s only in-depth bioscience industry in Colorado guide and directory to the bioscience industry. In honor Then, Now, The Future of our 10 years supporting the bioscience industry in Colorado, we will be celebrating our successful history and looking ahead to the future. 5 16 Over the past decade, the Association has The Science The Economic grown from a small startup enterprise to a mature A Decade of Dramatic Development and successful organization. This publication Developments: Building the Colorado is an integral part of the Association’s mission Bioscience in Colorado Bioscience Industry to support the Colorado bioscience community Cluster: through advocacy, resources and advancement of opportunities for collaboration. With a 8 A Remarkable total audience of over 15,000, including on- The Industry Success Story line impressions, this publication is one of the Colorado Bioscience: industry’s greatest voices locally, nationally and A Microcosm of 20 internationally. Broader Industry The Future In this issue of Bioscience Colorado we look at the entire bioscience ecosystem in the state. The Trends The Next 10 Years: articles examine elements that are meant to infuse Peering into scientific excitement, highlight the success of 12 Bioscience’s policy partnerships—both locally and nationally— The Public Policy Crystal Ball as well as milestones, and showcase the evolution Partners for Progress: of Colorado’s industry from one well below the Three Colorado national rankings to a cluster rising to the top 10. 28 We know that Colorado is on the edge of Governors & Their Colorado by the creating a critical mass. With some of the Commitment to Numbers top research institutions in the U.S., over 600 Bioscience bioscience companies, and employment growth 32 outpacing the nation we are energized by the Looking Back Bioscience Discovery momentum. Given the collaborative nature of Colorado, our researchers, leaders, entrepreneurs at 10 Years of Policy Evaluation Grant and companies are committed to our success. Milestones Program We look forward to serving the industry and (BDEGP) working with the bioscience community for the next 10 years. Produced by: Published by: Colorado BioScience Association Colorado BioScience Association and April Giles 216 16th Street, Suite 850 Colorado Office of President and CEO Denver, CO 80202 Economic Development Colorado BioScience Association www.CoBioScience.com and International Trade (303) 592-4073 Advancing Biomedicine in Colorado

The Anschutz Medical Campus and Fitzsimons Life Science District in Aurora is the nation’s newest health sciences city, integrating education, research (more than 1,100 research faculty and more than 2,500 researchers) and the best in clinical care (with three affiliated hospitals). In Boulder, the new Jennie Smoly Caruthers Biotechnology Building houses more than 600 faculty, staff and students from six CU- Boulder departments, helping create genuinely groundbreaking biotechnology research via the CU BioFrontiers Institute: a collaboration among CU-Boulder, the CU Anschutz Medical Campus and the University of Colorado Colorado Springs. CU is recruiting world-class interdisciplinary faculty for these and other initiatives, like the new Anschutz Center for Health and Wellness and the Department of Bioengineering at the Anschutz Medical Campus, and ongoing bioscience and technology efforts on the Boulder campus. CU has a track record of alliances with companies that enhance healthcare outcomes – CU research has led to four new approved drugs and numerous new diagnostic tests and medical devices, and CU is nationally prominent for new company creation, including biotech firms like Myogen (purchased by Gilead), GlobeImmune, ARCA biopharma, OPX Biotechnologies, SomaLogic, Taligen (purchased by Alexion) and over 70 others since 1994.

CU Denver | Anschutz $500M Medical Campus Bio-related sponsored research funding Strategic Research Initiatives Laura Simon, 303.724.4636 received annually by CU’s four campuses.

FDA-approved drugs developed at CU: Kineret, Macugen, Zostavax 4 and Botox (use). Connect with 200 biotech at CU Drugs, diagnostics and devices in CU’s active intellectual CU-Boulder New drugsNew in being tested 800 clinical trialsclinical by CU faculty property portfolio. BioFrontiers Institute Jana Watson-Capps, 303.492.3588 http://biofrontiers.colorado.edu Biotech companies founded based on CU 80 technologies, since 1994.

CU technologies currently licensed Technology Transfer to bio industry CU Denver|Anschutz: Rick Silva, 303.724.0222 partners 155 CU-Boulder, UCCS: Kate Tallman, 303.492.5732 www.cu.edu/techtransfer A Decade of Dramatic Developments: Bioscience in Colorado

BY Andrea Pawliczek

hink back to 2003. You may have just purchased your first cell phone with a camera. If you wanted to get in touch with a college friend or former colleague youT had to send an email or pick up the phone as Facebook was not online yet. For many of us, looking back at the use of personal technology may be the easiest way to see major developments over the last 10 years, but the changes that have affected scientific research are just as dramatic—and in some ways similar.

The human genome and personalized medicine The human genome project, which aimed to sequence the entire human genome—our full set of chromosomes—was initiated in 1990. In April 2003, the project announced that sequencing was essentially complete (a first draft was done in 2001), two years ahead of schedule. Understanding the human body at a genetic level has greatly influenced research to identify specific cellular pathways or confirm this over-expression before treatment and treatment of disease over the past decade mutations, create targeted therapies that may is initiated. This idea of not just considering as researchers have begun to inhibit a specific pathway, and develop feasible cancer by location or organ system, but also put this knowledge to use. tests to identify patients with particular by genetic profile has become increasingly Stuart Tobet, professor in the markers. The hopes that have begun to be important as the number of targeted cancer Department of Biomedical realized are that personalizing treatment will therapies (treatments that target specific Sciences at Colorado State make it both more efficient and effective. pathways) has exploded over the last 10 years. University, notes “Personalized The evolution of personalized medicine Dr. Paul Bunn, James Dudley Chair in medicine is a major trend that began with is perhaps most evident in the treatment of Cancer Research at the University of Colorado the sequencing of the genome.” Treatments cancer. Herceptin® (trastuzumab), approved Denver School of Medicine, notes that “There currently under investigation are developed by the FDA in 1998, was one of the first is definitely an opportunity for diagnostic specifically for groups of patients with drugs to be recommended for patients based companies,” who can develop companion particular genotypes or protein markers. on genetics. Specifically, Herceptin is only diagnostics for specific biomarkers that This work encompasses several non-trivial effective in patients with over-expression of identify the patients most likely to benefit from milestones from basic scientific research the HER2 gene, and thus patients are tested to a particular therapeutic.

BIOSCIENCE COLORADO 2013/2014 5 “Some of the research we want to do on live tissue would generate gigabits of data per second, and that sort of bandwidth is not that far away.”

As our understanding of how cells and systems work improves, the opportunity for different types of treatments beyond small molecules that act broadly on major systems emerges. Bunn sees both “the use of cell therapy and manipulated cells and immune Growing collaboration across therapies” as emerging areas that are likely disciplines to continue to increase in importance over With an increased knowledge base has the next several years. Cell therapies, which also come increased complexity, making it actually use living cells as treatment, and less likely that any one individual, or even immune therapies, which may activate or one department, possesses all the information suppress a patient’s immune system to fight or skills needed for significant advances a disease, require a greater understanding in research. Consequently, collaborative of how individual cells work and the means efforts have grown and continue to grow in through which these cells communicate and value. Tobet comments, “20 years ago I was interact with other cells. Understanding these interested in using mathematical modeling phenomena requires the ability to observe to look at neuronal movement, but the idea them; no small feat given the scale at and was not well received. Now there is a strong speed with which they occur. belief that modeling can inform design [in biomedical engineering] and in turn real-world More data faster data can inform the models.” In fact, many Nobel Laureate Tom Cech The same types of research that have organizations now have structures in place enabled today’s smartphones to have more to foster and encourage this cross-discipline hiring faculty committed to collaboration and memory and processing power than your first collaboration. by the new building, which puts researchers computer have also benefitted the medical Nationally, both the National Institutes from different disciplines in close physical research community. Along with computing of Health (NIH) and the National Science proximity. power, improvements in other technologies Foundation (NSF) have policies to support The Institute looks for opportunities to such as lasers and optics have allowed funding of collaborative projects. Many collaborate beyond the science community as researchers to acquire and analyze data in ways universities are also finding ways to encourage well working closely with the Deming Center that were unimaginable a mere 10 years ago. this type of cooperation. One example is the for Entrepreneurship at the Leeds School of More data can be collected faster, and with University of Colorado’s BioFrontiers Institute. Business (also on the campus of the University greater precision, than ever before. Scientists In 2003, the Institute, then called the Colorado of Colorado Boulder) and leaders from the are now better able to observe live tissue in Initiative in Molecular Biotechnology, was business community. Even with the increasing real time enabling an understanding that is initiated. About nine years later in April 2012, power and ability of computers, many view impossible from either the evaluation of dead the Jennie Smoly Caruthers Biotechnology this direct human communication as becoming tissue or static images. Any future advances Building on the University’s Boulder campus more and not less important in the future. in computing and related fields that enhance opened and now houses the Institute. On the opening of the new building Cech observational and data gathering abilities are Headed by Nobel Laureate Tom Cech and commented “People from my group walking likely to quickly be followed by new streams Chief Scientific Officer Leslie Leinwand, the down the hall past one of these research of medical research. As Tobet notes, “some of Institute aims to “advance human health and neighborhoods, for example, might be brought the research we want to do on live tissue would welfare by exploring the frontiers of biology into a scientific conversation with engineers generate gigabits of data per second, and that and translating new knowledge into practical or computer scientists from another lab, sort of bandwidth is not that far away.” applications.” These goals are facilitated by promoting the cross-fertilization of new ideas.”

6 2013/2014 BIOSCIENCE COLORADO Many key medical developments and products have connections to Colorado. Did you know…

n Richard Schmit developed Botox®-based treatments for several urological conditions including overactive bladder at the University of Colorado’s Anshutz Medical Campus in the 1990s. This research has netted CU $30 million in royalty payments.

n Colorado State Distinguished Professor Dr. Ed Hoover, in collaboration with researchers at Harvard, developed a vaccine made through molecular cloning of a feline leukemia virus. Sold under the trade name Fel-O-Vax®, this vaccine has been given to millions of cats worldwide. Due to vaccination, feline leukemia is now rare in pet cats.

n Myron Levin, M.D., a professor of pediatrics and medicine at the University of Colorado Anschutz Medical Campus, led the development of the vaccine for shingles. The vaccine, sold by Merck under the name ZOSTAVAX®, was approved by the FDA in 2006.

University of Colorado’s BioFrontiers Institute n Ambrisentan, sold under the brand name Letairis® in the US, was approved by the FDA in 2007 and by the EMEA in 2008 for the treatment of pulmonary arterial hypertension. The BioFrontiers program is far from alone Ambrisentan was the lead product candidate for Myogen, a company based in Westminster, in Colorado in its recognition of the importance Colorado, when it was acquired by Gilead in 2006. Sales of Ambrisentan totaled $410 million of collaboration. Many programs seek to in 2012, an increase of 17% from 2011. enhance cooperation both on and off campus. Among these is the CSU School of Biomedical n PharmaJet Inc., located in Golden, Colorado, recently became the first and only needle- Engineering, which is growing collaborations free injection company to receive Performance, Quality and Safety (PQS) pre-qualified across the CSU campus as well as across certification from the World Health Organization (WHO). This certification of the company’s northern Colorado. These include reaching out Stratis® jet injectors enables their purchase and use for mass immunization campaigns to medical professionals at the Medical Center conducted by WHO and UNICEF around the world. of the Rockies and in local industry.” More communication with people in the n Allosource, a non-profit based in Centennial, Colorado, has facilitated approximately medical community who are in touch with 100,000 live mesenchymal stem cell transplants worldwide. This volume makes the company patients can help inform future research to the world’s largest provider of stem cell tissue for surgeries. align it with medical needs,” Tobet notes. Despite the opportunities ahead, the road is not without challenges. One may be an increased focus on short-term benefits. Transforming Ideas into No longer are people willing to wait until www.lre.de + the morning paper to read the news instead Successful Products for 50 Years demanding real-time updates. With this focus, it may be hard for some to justify funding LRE Medical offers “One Stop Shopping” solutions for converting basic research that may not significantly “Concepts” into innovative and successful products. influence patient care for decades. Bunn comments that “government funding of unbiased free thought research is essential” and the uncertainty about future funding presents a significant concern. Taking a moment to look back at just how much has changed since 2003 may be one way to encourage that longer-term focus. The discoveries in basic science made 10 years ago are now moving to the clinic and changing the way patients are treated. With this view in mind, it’s easier to be optimistic about current research that has the potential to influence treatment in the decades to come. Design Development Manufacturing

BIOSCIENCE COLORADO 2013/2014 7 Colorado Bioscience: A Microcosm of Broader Industry Trends

venture-based risk capital, one is hard pressed What’s in a life science cluster? to identify another community, anywhere in the country, so vibrant and resourceful. Examining the state as a whole Despite the customary funding source shortcomings, those cowboy (and cowgirl)- starts with a wide lens. spirited Colorado entrepreneurs nevertheless account for a remarkably consistent launch of 20 or more start-ups standing up each year. By Adam Rubenstein The entrepreneurial gene is ubiquitous among science and management teams from Colorado Springs to Denver to Boulder to Fort Collins. ith nearly 600 therapeutic, device, These savvy teams have secured financing diagnostic and ag-bio companies, from a diverse array of non-traditional and a workforce totaling just a hair capital sources, such as corporate venture, under 15,000 the Colorado biosci- foundation-based patient advocacy and Wence ecosystem has, over the past 10 years, venture philanthropy groups, as well as from scratched, clawed, fought and, more impor- an accelerating organizing angel community, tantly, grown. This up-and-to-the-right trend and non-dilutive grant-based sources, which has endured despite diverse hurdles littering works wonders towards reducing eventual its path. But these are not unique challenges institutional capital risk via the demonstration faced solely in the Rocky Mountains. Alas, the of proof-of-concept. entire industry has had to learn to adapt to the Academicians are at the heart of turbulence that has marked the period of 2003- innovation, and Colorado boasts no less 2012. And, as Tim Rodell, M.D., president and than 10 higher education institutions with CEO of Louisville-based GlobeImmune so bioscience programs. Some of these centers adroitly illuminated, the Colorado Bioscience of excellence include the University of ecosystem, in its purest form, is a microcosm Ginger Graham, former president and CEO of Colorado’s Cancer Center and Charles C. of broader industry trends. Amylin Pharmaceuticals and current Harvard Gates Center for Regenerative Medicine Longtime Colorado resident and former Business School Senior Lecturer and Stem Cell Biology, and Colorado president and CEO of Amylin Pharmaceuticals State University’s integrative program in and current Harvard Business School Senior biomedical engineering and renowned College Lecturer, Ginger Graham, pointed to a proficient at all of the diverse aspects of of Veterinary Medicine and Biomedical very critical differentiating factor present life science discovery, development and Sciences. The entrepreneurial velocity among in Colorado and perhaps its most precious commercialization. While the Front Range is the faculty at these centers is powerful and asset—its people, a group that is remarkably plagued by a woeful deficiency in traditional easily quantifiable, as determined by grant

8 2013/2014 BIOSCIENCE COLORADO dollars received. The output data from these the high failure rates of early-stage life faculty have earned the right to be proud of awards commonly yield intellectual property- science companies, is that 78 of them are (Fig. 1). Nationally, Colorado consistently based assets that ultimately form the basis for known to be operational today. Boulder- ranks among the top-five recipients over the spin-out start-up companies. For example, based Collective IP, an information company last ten years for median grant funding dollars from 2003 to 2012, there were 86 start-ups focused on curating innovation, has amassed from the National Science Foundation (NSF). that emerged from the University of Colorado data points that illuminate certain trends and These grant awardee leadership positions alone. Perhaps even more impressive, given leadership positions that Colorado-based go beyond NSF funding. For example, Top 5 NSF Grant Funding Recipients by Year Top 5 NSF Grant Funding(1990-2012) Recipients by Year (1990-2012) $1,600,000,000

$1,400,000,000

$1,200,000,000 Median US

CA

MA $1,000,000,000 NY

PA

$800,000,000 TX IL Amount ($)

NC $600,000,000 WA

CO

Linear (Median US) $400,000,000 Linear (CA)

Linear (CO) $200,000,000

$- 1990 1995 2000 2005 2010 2015 Effective Date (Year)

BIOSCIENCE COLORADO 2013/2014 9 Colorado Assignee Issued Patents and Patent Applications (2003-2012)

900 800 700

Apps 600 500 400 300 otal Patents + T 200 100 0 Chemistry: Chemical Radiation Combinatorial natural resins Prosthesis Adhesive apparatus Drug, imagery Chemistry: Drug, Chemistry: Chemistry: chemistry or derivatives; (i.e. artificial bonding and and process Chemistry bioaffecting chemistry: analytical bioaffecting electrical molecular technology: peptides or body members), miscellaneous disinfecting, of inorganic and body process, and and body Surgery Total and wave biology and method, proteins; parts thereof or chemical deordorizing, compounds treating composition, immunological treating energy microbiology library, lignins or aids and manufacture preserving or compositions or product testing compositions apparatus reaction products accessories sterilizing thereof thereof 2003 16 7 27 11 44 32 56 18 0 40 15 117 8 391 2004 29 16 24 16 57 24 101 15 2 146 28 118 1 577 2005 23 16 21 8 64 22 102 18 2 108 32 164 9 589 2006 18 18 15 10 68 30 112 24 3 96 26 233 13 666 2007 23 15 24 19 79 28 160 19 12 89 33 208 16 725 2008 22 43 17 14 61 23 107 20 14 110 24 225 13 693 2009 30 17 23 20 79 11 117 21 11 112 35 325 16 817 2010 29 33 36 17 68 3 102 28 19 73 25 307 14 754 2011 31 14 24 12 41 2 93 13 22 72 27 253 14 618 2012 11 11 21 3 17 1 28 3 9 31 4 103 13 255 in 2012, the National Institutes of Health early-stage drug development and an increase, Oncology closed a mammoth Series A awarded a whopping 894 grants across seven on a relative basis, in ease of availability to financing, totaling $146 million. This capital congressional districts that totaled $304 device investors. Some believe this shift in was contributed by blue chip funds from million in research funding. sector allocation investment is due in part to both coasts including Domain Associates, Translating these principal investigator the general relative elements of lower cost of New Enterprise Associates, Versant discoveries into commercial enterprises is no capital for devices to reach commercialization Ventures, Aberdare Ventures, Abingworth, easy task. Thankfully, Colorado institutions compared to a drug, along with lower Frazier Healthcare Ventures and ProQuest can leverage a community of savvy and regulatory hurdles, and a compressed time to Investments. In 2012 the company, in a sophisticated technology transfer offices liquidity opportunities (be they M&A, IPO or continued inhospitable market environment, (TTOs) and officers who lend critical domain even flowing positive cash). continued to buck the trend, floating its expertise to this critical period in the early Over our ten-year time period in review, initial public offering and pricing 3,750,000 life of an innovative piece of technology. Colorado life science companies have also shares at $20 totaling $75 million. Given the Year after year, the work of these networked experienced the good fortune of some challenge of broader market climates, this TTOs continues to add fuel to the Colorado tremendous billion dollar plus liquidity was some truly extraordinary private and bioscience ecosystem engine in the form of events, validating both the scientific and public financings for this small molecule and new company formation. From market and IP management team quality and acumen present companion diagnostic company focusing analysis, business architecting, management in the region. Some of these deals included on non-small cell lung, ovarian and breast recruitment and more, these offices perform at Ribozyme/Sirna acquired by Merck (NYSE: cancers. the highest levels—and their efforts bear the MRK) for $1.1 billion, Gilead’s (NASDAQ: Many may perceive the fundraising fruit of aiding the translation of intellectual GILD) acquisition of Myogen for $2.5 billion, successes experienced by Clovis to be several property onto a commercial trajectory. Celgene’s (NASDAQ: CELG) acquisition of standard deviations from the mean, and An interesting trend in the generation of Pharmion for $2.9 billion, and most recently rightfully so, Colorado has derived alternative Colorado-based intellectual property, in both Alexion’s (NASDAQ: ALXN) acquisition of mechanisms for the continued funding of applications and issued patents, from 2003- Taligen Therapeutics for $111 million up front medical innovations. One such success story 2012 is a distinct shift away from drug-based and upwards of an additional $500 million in is the Colorado Institute for Drug, Device and IP and an increased output of medical device play based upon clinical milestones. Diagnostic Development (CID4). Founded (surgery)-based IP (Fig. 2). Perhaps this trend While many companies were challenged in 2009, CID4 is a 501(c) (3) not-for-profit is not all that surprising given the contraction to raise traditional venture dollars during the charitable organization whose mission is to in access to the therapeutic-based capital for post-2008 turmoil, Boulder-based Clovis advance the Colorado bioscience ecosystem

10 2013/2014 BIOSCIENCE COLORADO through company creation and job growth. the sky. The phenomenal progress of residential development). Simply amazing. With support from the Colorado Office for glistening new research towers, hospitals Throughout the past ten years Colorado Economic Development and International and academic buildings now occupies what legislation has also had a dramatic impact Trade and the Fitzsimons Redevelopment was once a clean view towards the heartland. upon the growth trajectory of the life science Authority, CID4 provides promising post With groundbreaking in 2004, the 587- ecosystem. Back in 2006, House Bill 1001 led proof-of-concept entities not only with acre Fitzsimons Life Science District and to the creation of the Bioscience Discovery capital, but with active business management the adjacent Anschutz Medical Campus in Evaluation Grant Program (BDEGP), designed assistance—all in an effort to bridge the gap Aurora is one of the largest bioscience real specifically to expand bioscience research and between discovery and product development. estate developments in the country. The accelerate the development of new products CID4 has made a number of investments former military base site is now home to the and services disbursed through Proof-of- in companies such as diagnostic-focused University of Colorado and University of Concept grants, Early-Stage Bioscience KromaTiD, medical IT-focused Flashback Colorado Hospital and the Children’s Hospital Company grants and research institution grants Technologies, canine oncology-focused and Research Center. Development at the for infrastructure development. Since the VetDC, influenza vaccine-focused PeptiVir, square-mile-of-life-science city is ongoing. program’s inception, 130 grants totaling $22.1 and a medical hearing device company The campus will soon welcome the completion million were distributed to research institutions Sophono. Boulder-based Sophono was the first of the Veterans Administration Hospital, the and early-stage bioscience companies to investment made by the non-profit, and in the Colorado State Veterans Home, and continued advance research and development in a variety summer of 2012 the company closed their first build-out of the Fitzsimons Redevelopment of disease areas. Today, House Bill 13-1001 institutional financing, totaling $7 million, led Authority Bioscience Park Center, not to or the Advanced Industries Accelerator Act by Greenwich, CT-based Wexford Capital. By mention the ongoing addition of conference has been introduced to the Colorado General reaching this important milestone, Sophono facilities, restaurants, apartments, parks and Assembly; the proposed Bill models itself also earned the unique distinction of becoming hotels. Upon completion, investment in the after the BDEGP. While the past ten years have CID4’s first alum company. Anschutz Medical Campus and Fitzsimons yielded uncanny progress towards a maturing Over the past 10 years, if one were Life Sciences District will be in excess of $5 bioscience ecosystem, many resources that traveling from Denver International Airport billion dollars, will contain in excess of 18.5 had not previously existed that are now in west along I-70 headed towards downtown million square feet of new construction, and place are certain to accelerate development of Denver, it would be near impossible to miss employ over 45,000 people (not including the unique bioscience cluster along the Front the flurry of construction cranes scrapping surrounding office, retail, hospitality and Range of the Rocky Mountains.

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BIOSCIENCE COLORADO 2013/2014 11 Novella_Mech_Colorado_BiosciencesAd.indd 1 3/1/13 1:32 PM Partners for Progress: Three Colorado Governors & Their Commitment to Bioscience

dedicating a high-level director for the bioscience By Sean Duffy industry in the state’s Office of Economic Development and International Trade—a move ame an American industry that unites that sent a signal around the country that Colorado political parties, diverse ideologies was serious about being a bioscience hub. and competing regions of the state “It was clear to me early in my time as behind the idea that, with the right Governor that bioscience had the potential to be Npolicies, it can be a pillar of economic a strong, lasting economic driver for Colorado,” progress. The list is a short one, and, Owens says today. “We created a pro-growth tax for the past ten years, it has been climate which helped us in our goal of making Colorado’s bioscience industry that Colorado a hub for innovation, cutting-edge has been the leader. technology and risk-taking entrepreneurs. That One of the pioneers who two-pronged strategy created a fertile environment recognized the significant for Colorado’s bioscience industry.” economic promise of the bioscience Owens not only wanted Colorado to be a home industry was Governor Bill Owens. for the industry, he also helped establish a first During his eight years as Colorado’s home for the Colorado BioScience Association chief executive, Owens made by ensuring that CBSA had office space free of bioscience a central priority of charge at the Advance Colorado Center in Denver. his economic development A crossroads decision for Gov. Owens was strategy and was whether—and how—to accelerate the build-out instrumental in helping of the new health sciences campus at the former companies take root Fitzsimons Army Medical Center. At that point, here. In fact, he took the master plan would have taken literally decades the lead in to complete, despite the fact that the bioscience industry evolves at lightning speed, and economic opportunities can evaporate as quickly as they materialize. “We simply had to seize the opportunity to speed up the construction schedule by decades, and, working with the Legislature and CBSA, we did so,” Owens recalls. “Had it proceeded at an incremental, piecemeal pace, we would have lost the opportunity to make what is now the Anschutz Medical Campus a magnet for innovation that is drawing economic activity from around the world.” For his leadership, vision and proactive record of success in establishing a firm foundation for the industry in Colorado, CBSA awarded Governor Owens the 2006 Lifetime Achievement Award. Thanks to broad and growing support among policymakers in both political parties and from

12 2013/2014 BIOSCIENCE COLORADO every corner of Colorado, the industry’s investment in terms of new, high-quality jobs, “When we talk about a bottom-up momentum was strong as Gov. Bill Ritter, and solid investment in our state.” economic development philosophy, we see Jr. took office in 2007. From day one of his Ritter proudly notes that this commitment it at work in bioscience, as this sector shows administration he was a public champion of was instrumental in drawing a Nobel laureate the benefit of strong local collaborations bioscience, and appointed Cabinet and senior back to the University of Colorado to open a among the private sector, government and staff members who embraced the industry’s new “BioFrontiers” institute. higher education—collaborations that have economic benefits. Over his four years in office, Ritter helped produced huge dividends for Colorado and for Ritter cemented his commitment to lay important groundwork for future strategic the country,” the Governor said. “Across the bioscience by naming the industry one of the growth in bioscience companies and jobs, political spectrum, there’s strong consensus four sectors he believed would be economic most notably through the production of about not only promoting bioscience, but also drivers for the state, and included bioscience in the “Colorado Bioscience Roadmap.” This finding elegant, cost-effective methods to help his annual economic development agenda. detailed document not only helped guide the existing companies expand, bring new jobs to A hallmark of Ritter’s term as Governor successes of the Ritter Administration, but also Colorado and help new companies bring good was his support for landmark legislation that helped provide valuable continuity when Gov. ideas to the marketplace.” created the Bioscience Discovery Evaluation John Hickenlooper took office in 2011. The successful path the industry has Grant Program, which is still going strong Following in the footsteps of his two walked over a decade—with three governors today. The results are robust, with 34 new predecessors, Hickenlooper has been strongly and both parties in control of the House and companies created, generating over 1,000 supportive of the bioscience industry, Senate at various points—is the exception direct and indirect jobs. Equally important, the including support of legislation in 2010 rather than the rule in economic policy. program helped drive more than $100 million that helped extend the hugely successful Colorado’s bioscience industry has grown in outside investment to Colorado companies. Bioscience Discovery Evaluation Grant by uniting policymakers behind innovative “My belief was—and is—that our Program (BDEGP) through 2018. This model initiatives that have brought out the best commitment to bioscience can set Colorado is so successful that this year Hickenlooper among entrepreneurs and company leaders. apart as a vibrant center for high-tech, and his economic development team are As a result, Colorado’s economy—and high-quality 21st century jobs, and we were working to advance a new Advanced international reputation as a home for right,” Ritter says. “By promoting legislation Industries Accelerator Act, which models the great companies—has expanded, and will that helped jump-start fledgling bioscience BDEGP for seven key industries in the state, continue to grow as CBSA enters its second companies, we saw a huge return on including bioscience. decade.

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BIOSCIENCE COLORADO 2013/2014 13 Looking Back at 10 Years of Policy Milestones

ooking back over the last decade of Medical Device/Diagnostic Policy THE MEDICAL DEVICES TECHNICAL federal policy, you can’t help but notice CORRECTIONS ACT (2004) the overwhelming attention focused on THE MEDICAL DEVICE USER FEE AND Amended certain provisions of MDUFMA health care policy. Our world today has MODERNIZATION ACT (MDUFMA) (2002) to clarify requirements that prevented aL completely new vocabulary due to the ever Gave the FDA the authority to collect user manufacturers from participating in the evolving federal health care landscape, from fees from product sponsors for review third-party inspection program and create Accountable Care Collaborative and IPAB, activities, among other provisions. The a moratorium on branding requirements to Dual Eligibles, Essential Health Benefits law established a system for the FDA to originally intended to apply only to and so on. The majority of these health policy collect user fees from product sponsors, a reprocessors of single-use devices. changes will have both direct and indirect im- mechanism for determining fees for different pacts on the future of the bioscience industry. product applications and an adjustable THE MEDICAL DEVICE USER FEE During the health care policy debate, formula for determining increases in fees for STABILIZATION ACT (MDUFSA) (2005) the Colorado BioScience Association has the first five years of the program; required Amended certain provisions of MDUFMA that worked hand in hand with our national Congress to provide increased appropriations would have forced the premature sunset of the counterparts at AdvaMed, the Biotechnology for the FDA’s device center; required medical device user fee program, among other Industry Organization (BIO), Medical Device reprocessors of some single-use medical provisions. The law eliminated the automatic Manufacturers of America (MDMA), and devices to submit additional premarket user fee sunset that would have been triggered PhRMA to align our community in order to validation data to the FDA and to adhere because Congress did not meet its MDUFMA protect the best interests for companies here to new labeling and branding provisions; appropriations commitment; set application in Colorado. We asked our national allies to established a third-party inspection program fee rates for the final two years of the program, look back over the last 10 years with us and for eligible medical device facilities; and eliminating the formula previously used for highlight some of the key issues that have made created an Office of Combination Products setting the rates; and clarified that MDUFMA a significant impact on our industry today and within the FDA to oversee regulation of drug/ branding provisions apply only to reprocessors will affect the future of our industry tomorrow. device/biologics combinations. of single-use devices.

THE FDA AMENDMENTS ACT (FDAAA) (2007) Reauthorized the medical device user fee program through the end of fiscal year 2012, among other provisions, including reauthorizing the third-party 510(k) review and facility inspection programs and calling for the FDA to develop regulations to establish a unique device identification system.

Innovation THE FDA SAFETY AND INNOVATION ACT (FDASIA) (2012) Reauthorized the medical device user fee program through the end of fiscal year 2017 at Work and included robust, new FDA performance goals requiring the agency to reduce total review times—measured for the first time from the time of submission to the time the FDA makes a final decision on a PMA or a 510(k)—and significantly improve review performance relative to current performance. These included: • “Leave no submission behind” by requiring the FDA to meet with companies if a performance goal on a PMA or 510(k) is missed and work out a plan for completing the review • Provision of a substantive interaction with applicants halfway through the targeted time www.csuventures.org 970.491.7100 for completion of a review • Implementation of an analysis of the FDA’s

14 2013/2014 BIOSCIENCE COLORADO management of the review process by an The 2008 Farm Bill created additional programs PUBLIC READINESS AND EMERGENCY independent consulting organization, coupled to support capital formation and feedstock PREPAREDNESS ACT (2005) with an FDA corrective action plan to address supply chains for large-scale biorefineries. This legislation provided immunity opportunities for improvement. These programs successfully addressed for liability claims arising from the industrial biotechnology’s greatest challenge— administration and use of covered Biotech/Pharma Policy developing a “biobased economy” where countermeasures to manufacturers, renewable agricultural feedstocks are distributors, program planners and qualified MEDICARE PRESCRIPTION DRUG AND converted to higher value products including persons involved in the administration and MODERNIZATION ACT (2003) biofuels and renewable chemicals. use of a covered countermeasure. The Medicare Part D benefit has helped to Because of this legislation, many increase patient access to critical therapies ENERGY POLICY ACT (2005) AND ENERGY biotechnology companies are now able to as well as ensure that patients will be able INDEPENDENCE AND SECURITY ACT (2007) aggressively focus their next-generation to receive and afford the treatments that The Energy Policy Act established the first- technology and cutting edge R&D on best meet their needs. Many of the therapies ever federal Renewable Fuel Standard, and the preparing for, and responding to, very serious developed by biotechnology companies Energy Independence and Security Act greatly threats to America’s public health security. As target conditions that primarily affect expanded it in order to improve domestic a result, our nation is, and will continue to be, seniors. This landmark legislation ensures energy security and reduce greenhouse gas safer and healthier. that the patients who need medicines the emissions from transportation by setting most have access to them. goals for production of renewable fuels made PANDEMIC AND ALL HAZARDS PREPAREDNESS from U.S. biomass resources. In addition, ACT (2006) FARM SECURITY AND RURAL INVESTMENT the act authorized $3.6 billion in funding This legislation represented a major step ACT (2002) AND FOOD, CONSERVATION AND for bioenergy and biobased products and in developing the role of America’s public ENERGY ACT (2008) established a tax credit for cellulosic biofuels. health and medical systems in preparing The 2002 Farm Bill established federal These pieces of legislation represented a big for and responding to major emergencies. programs to create new markets for biobased step toward enhancing our national security by Reauthorized in 2013, the program continues products and support research in bioenergy, providing incentives for energy produced from to improve our nation’s public health expanding the tax credit for cellulosic biofuels. renewable agricultural feedstock. and medical preparedness and response

BIOSCIENCE COLORADO 2013/2014 15 capabilities for emergencies, whether unmet medical need or prevent, detect or BIOSIMILARS LEGISLATION (2010) deliberate, accidental, or natural. treat chronic or acute diseases or conditions; The Patient Protection and Affordable Care reduce the long-term growth of healthcare Act was the largest overhaul of the U.S. QUALIFYING THERAPEUTIC DISCOVERY costs in the United States; or significantly healthcare system in over four decades. PROJECT PROGRAM (2010) advance the goal of curing cancer within 30 Among the many provisions within this This program was enacted as part of the years. bill was an approval pathway for biological Patient Protection and Affordable Care Act This program proved to be a lifeline for products that are demonstrated to be of 2010 and is available only to companies innovative biotechnology companies. BIO “biosimilar” with an FDA-licensed biological with 250 or fewer employees. Grants and hopes Congress will consider extending and product. This provision protects patient safety tax credits were awarded to small biotech expanding this program to support American and promotes investment through providing companies working on projects that showed innovation and speed the development of innovators with 12 years of data exclusivity. a reasonable potential to: treat areas of lifesaving cures. SMALL BUSINESS INNOVATION RESEARCH PROGRAM (2011) This reauthorization reinstated eligibility for a vast majority of small biotechnology companies that had been shut out of the program for the past decade, due to a regulatory Intellectual Asset Management magazine ruling that made small companies who have ranked Sheridan Ross second in the U.S. majority venture capital funding ineligible. in securing the highest-quality patents in the healthcare sector. SBIR provides a critical source of funding for and... emerging biotechnology companies in the early development stages of medical research; the The National Institutes of Health selected changes included in the reauthorization enable Sheridan Ross as one of only six patent rms a larger number of small companies to compete to protect its biotechnology inventions. for funding, thus ensuring that the program will be able to fund small biotech companies’ You can’t argue with that. projects that have the greatest potential to bring Protecting ideas in the bioscience industry for more than 25 years innovative medical treatments to the patients who need them.

Denver 1560 Broadway / Suite 1200 / Denver, CO 80202 / 303.863.9700 AMERICA INVENTS ACT (2011) Colorado Springs 24 S. Weber St. / Suite 205 / Colorado Springs, CO 80903 / 719.749.6013 This legislation, the first comprehensive www.sheridanross.com re-write of America’s patent laws in nearly 60 years, moved America from a “first to invent” to a “first to file” patent system. Additionally, the legislation created new, fair post-grant administration opposition proceedings for those seeking to challenge patents shortly after issuance. The patent system, so incredibly important to life sciences innovation, was made more predictable and transparent due to these reforms. Furthermore, this legislation helped end DEMAND the diversion of fees collected by the U.S. Patent and Trademark Office, increased the objectivity of our patent system, and increased patent quality. This improved system is good EXPERTS for inventors and investors, hence good for business and jobs in America. BURNS MARKETING BECAUSE WE’RE FLUENT IN BOTH FOOD AND DRUG ADMINISTRATION SAFETY LIFE SCIENCES AND SUCCESS. AND INNOVATION ACT (FDASIA)/PRESCRIPTION DRUG USER FEE ACT REAUTHORIZATION (2012) 970.203.9656 www.burnsmarketing.com FDASIA, which included a reauthorization of the Prescription Drug User Fee Act (PDUFA), enhanced the development and

16 2013/2014 BIOSCIENCE COLORADO review of innovative new therapies through increased transparency and early scientific dialogue, advancements in regulatory science and reforms to the “accelerated approval” review system at the FDA. The PDUFA reauthorization itself will ensure the continuation, for five years, of a very successful user fee program, which has resulted in expediting drug review times at the FDA. Over the past 20 years, PDUFA has ensured a more predictable, consistent, and streamlined premarket program for industry and helped speed access to new, safe and effective prescription drugs for patients.

JUMPSTART OUR BUSINESS STARTUPS (JOBS) ACT (2012) This new law included several important policies designed to stimulate capital formation for growing businesses— including those in the biotech industry. This legislation makes capital formation easier for small biotechnology companies, enabling them to focus more on curing and treating disease.

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BIOSCIENCE COLORADO 2013/2014 17 retention, workforce development, critical infrastructure, environmental sustainability, Building the social inclusion, neighborhood development, health, safety, literacy, and other initiatives. Colorado Bioscience A key driver of success in economic development has been industry clusters— geographically concentrated areas where related government agencies, institutions of Industry Cluster: higher learning, and commercial enterprises share common needs for talent, technology, and infrastructure. A Remarkable How we became a bioscience state The inspiration for the Metro Denver EDC and the expansion of the nascent Colorado BioScience Association (CBSA) came from Success Story a 2002 initiative by the Governor’s Office of Innovation and Technology. Clark says that research from Michael Porter at the Harvard By Jeanne McAdara-Berkowitz, PhD Business School had shown that achievement of regional competitiveness comes not from trying to recruit a few “hot” companies to an ewcomers to the state of Colorado area, but by creating a self-sustaining economic are likely to look at our diverse “We’re improving people’s ecosystem that is not primarily dependent on economy, high-wage job base, and health and their lives.” outside infusions of money and investment. highly educated workforce and assume “By this time we had the Denver Nour state represents another spontaneous, International Airport, we had cleaned up our homegrown ecosystem like the bioscience air quality, and we had a bustling downtown centers in Boston and San Diego, or the with public transportation, arts, culture and high-tech industry hub in Silicon Valley. But the high-rise feel attractive to metropolitan to those who had a hand in the last decade’s dwellers. Now we needed industry clusters,” flurry of economic development activity, the says Clark. “We decided that our initial real story is much more interesting. clusters would be bioscience and aerospace, In fact, Colorado’s bioscience industry— and the next question was ‘how do we become which employs 27,000 people, translating to a bioscience state?’” more than 122,000 direct and indirect jobs To answer that question, the Governor’s and $10 billion in payroll for the state—is Office partnered with a management team that an amazing success story that has proven included industry, university and government the effectiveness of purposeful economic representatives—along with the Battelle development. Memorial Institute’s Technology Partnership “When the team started this push to Practice—to assess the status of the Colorado develop a bioscience industry cluster 10 bioscience sector and develop a plan years ago, it was really kind of a giant Tom Clark, chief executive officer of the Metro outlining the action agenda needed to make social experiment,” recalls Tom Clark, Denver Economic Development Corporation the biosciences a key driver of Colorado’s chief executive officer of the Metro Denver (MDEDC) and executive vice president of the economy. That report, “Colorado’s Place in Economic Development Corporation Denver Metro Chamber of Commerce. the Sun: A Bioscience Future, An Action Plan (MDEDC) and executive vice president of to Grow Colorado’s Bioscience Cluster,” was the Denver Metro Chamber of Commerce. frankly, I think we’re all pretty amazed that it published in March 2003 and outlined several “We were wondering whether we could worked,” Clark laughs. key findings that kicked off the state’s focus really do it. Well, last May the Biotechnology Metro Denver is a textbook example for on developing Colorado as the next bioscience Industry Organization issued new state-by- how to do purposeful economic development business cluster. state bioscience industry rankings, and in correctly. The term refers to a coordinated, “Number one, it showed that we definitely that report Colorado had moved from near sustained effort by stakeholders and weren’t a bioscience state,” Clark laughs. “But the bottom of the overall rankings up to the policymakers to promote local economic it also told us that we had to accomplish three bottom of the top-tier states.” health, social well-being, and regional things in order to become one. We needed “It’s been a huge accomplishment and competitiveness through job creation and to establish a locus of economic activity, we

18 2013/2014 BIOSCIENCE COLORADO PHOTO © TIM O’HARA, O’HARA PHOTOGRAPHY © PHOTO The Rocky Mountain Innosphere, Fort Collins, Colorado

in to Denver have inspired companion efforts in Northern Colorado, especially around the Colorado State University (CSU) campus in Fort Collins. The Rocky Mountain Innosphere, a technology accelerator in Fort Collins, has been a leader in the recent push to develop needed an industry or academic ‘superstar’ to Fitzsimons Redevelopment Authority, the bioscience presence there. Mike Freeman, help attract other talented people here, and we Bioscience Park Center, Aurora, Colorado CEO at the Innosphere, says that they made needed a mechanism for funding the proof- the conscious decision to broaden their focus of-concept studies that move technology out (FRA), one of the entities involved in the from technology, hardware, and software of the basic research lab and into commercial development of the Fitzsimons Life Science in 2004, when they noted the beginnings of development.” District that neighbors the Anschutz Campus. increased bioscience activity. The team set out to make these As a newcomer to Denver—Vannurden just “We realized that in northern Colorado recommendations a reality. The CU Denver joined the FRA in August 2012—he agrees there was not a huge concentration of Anschutz Medical Campus was already that the early development efforts are paying bioscience companies and, out of CSU, we in the process of being built out, and low off for long-term success. were most likely to see technologies coming interest rates made it possible to accelerate “As I was looking at coming here, I saw from the veterinary school or infectious that development plan. In 2006 the legislative major healthcare players with Children’s disease department,” says Freeman. “So advocacy efforts of CBSA paid off with Hospital, the University of Colorado with that focus we have built up enough of the passage of HB 1360. Sponsored by Hospital, the CU medical, nursing, dental, an ecosystem to legitimately support eight Representative Jim Reisberg (D-Greeley) and pharmacy schools all together in one biotech companies [at the Innosphere] in and Senator Ron Tupa (D-Boulder), this bill place,” says Vannurden. “It was a critical set addition to our other companies.” By recent appropriated $2 million to fund grants for of stakeholders right there on campus, around estimates, Fort Collins is home to well over 50 bioscience proof-of-concept work and opened which we can build a sustainable life science young and growing bioscience companies. the doors to additional legislation that resulted community.” In Freeman’s view, collaboration with in the establishment of the Colorado Office What the FRA aims to do is not only CBSA has been critical to the region’s of Economic Development and International provide infrastructure to attract life science success. “In the early years we didn’t have Trade’s Bioscience Discovery Evaluation companies to settle in close proximity to a formal entity like the CBSA, so working Grants. And homegrown Nobel Laureate Tom academic sources of technology, but to with them and the City of Fort Collins gave Cech—who briefly left Colorado to become facilitate collaborations and streamline us the ability to promote the industry here, president of the Howard Hughes Medical commercialization. help build a brand around Northern Colorado Institute in Maryland—was persuaded to “What’s interesting to me, personally,” says Bioscience, and collaborate on co-branded return to CU Boulder, bringing with him four Vannurden, “is that we have such a unique events and panels. Expanding on this, I see rising stars and leading to the advent of the opportunity to create the future of medicine 2013 as a critical year for us to tighten our BioFrontiers Institute. right here on campus. This is an environment integration with CSU ventures and technology “Those accomplishments, along with the where we can take scientific talent, intellectual transfer, and find new ways to work together expansion and support of the CBSA as a property, and entrepreneurial activity, and with CBSA and with CU health sciences.” critically important advocacy organization, put them together to advance the practice of Bioscience economic development efforts at have set us on the right course,” says Clark. medicine and benefit patients across the US CSU dovetail nicely with the Innosphere’s plans, “The world started to look at us and pay and around the world while creating good, says Rick Lyons, director of the Infectious attention.” high-paying jobs for Colorado. It’s good for Disease Research Complex and Supercluster, Steve Vannurden is the president and CEO all of us.” and the Research Innovation Center (RIC) at of the Fitzsimons Redevelopment Authority The economic development efforts close CSU Fort Collins. “The RIC and the Innosphere

BIOSCIENCE COLORADO 2013/2014 19 companies housed there are homegrown, and most of the rest had close CSU connections. “We offer a turnkey facility for infectious disease companies,” he says. “We provide built-out, biosafety-level-2 laboratories with all of the approved HVAC and other utilities they need to get going right away. We think that will help to drive entrepreneurship and build momentum for a novel paradigm of industry-academic collaboration here at CSU.” Looking southward from Denver, the past 10 years have seen dramatic growth in bioscience in Colorado Springs as well. David White, chief business development officer at Colorado Springs Regional Business Alliance, says that the medical device industry has have a very tight relationship. We kind of view Research Innovation Center (RIC) at CSU Fort proven a particular bright spot there. our two sites as the infrastructure for the city Collins, Colorado “We’ve seen a sizable increase in all of Fort Collins. When companies come here forms of bioscience activity here, but medical our collaboration puts us in a better marketing members, and assist in translating innovative devices seem to be a particular strength position to make sure they are aware of discoveries into products. In support of that for Colorado Springs,” says White. “Our opportunities, and then we can work together goal, the RIC building was opened in 2011. region features an interesting intersection of to place them where they’ll be most successful This facility houses CSU faculty on the first sports and human-performance technology, depending on their needs.” floor and a research incubator on the second military and defense applications, information According to Lyons, the goals of the floor, bringing academics and entrepreneurs technology and software, manufacturing, CSU infectious disease supercluster are to into close proximity for cross-talk and medical device companies, and universities, encourage entrepreneurship among faculty collaboration. Lyons estimates that 40% of the and we are seeing these sectors working

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20 2013/2014 BIOSCIENCE COLORADO together to form new opportunities.” Challenges down the road “One thing we consistently hear from the White notes that a number of companies companies we talk to is that they are finding it have either grown up in Colorado Springs or All of this is not to say that Colorado’s necessary to import talent,” says White. “We migrated here from California and elsewhere industry cluster’s challenges are safely in the as a community and a region need to work in the past few years, drawn by the high rear view mirror. The consensus among those on continually improving our educational standard of living and a cost of doing business interviewed was that the biggest challenges, system so that companies here can rely on that is attractive to manufacturing companies. for now, are related to lack of locally sourced local, homegrown talent to fuel growth and Combined, these companies employ thousands funding and investment. innovation.” of people and provide a nucleus for the “There is a real ‘can-do’ attitude in these Whatever the future holds, the architects industry. companies, but that only carries them so far,” of Colorado’s economic development Scott Hawranek, a Colorado Springs says Lyons. “Ultimately, they need access to successes can look back over the last decade intellectual property attorney adds, “We also venture capital.” with pride. Says Clark, “There are so many have a good number of startups working to Freeman agrees. “There are few active heroes in this story, and what they’ve proven bring their devices and combination products funds in Colorado that will entertain proposals is that we truly can change the shape of our to the next level. At their stage, they are from biotech. So the issue looms: can we be economy. In 1983, Colorado’s economy relied aided by the ready availability of prototyping successful without a strong local investor pretty heavily on fossil fuels. We weren’t facilities and regulatory and intellectual base, or will startups move to Boston or San in the top 25 states in terms of diversity of property services here.” Francisco once they need significant funding?” economy, and now we’re ranked third behind No matter what part of the state, an White also worries about the potentially California and New York. Bioscience has inclination toward collaboration and chilling effect of new tax legislation, such as been an important part of that diversification excitement for the future seems to be shared the Medical Device Excise Tax. “It’s going to strategy.” throughout Colorado. Says Vannurden, “We’re be very challenging for companies to expand Why does this matter? Because bioscience, all working together pretty closely because if their profits have to go toward this tax,” he as an industry, creates primary jobs and high acting separately doesn’t give us the strength says. wages to satisfy Colorado’s highly educated we need. Rather than having to fight over the Finally, White asserts that workforce workforce. size of our individual slices, the focus is on development will be another area for focused “And also, it’s cool,” says Clark. “We’re making the whole pie bigger for all of us.” improvement over the next decade. improving people’s health and their lives.”

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BIOSCIENCE COLORADO 2013/2014 21 Ralph E. “Chris” Christoffersen PhD is a The Next 10 Years: partner at Morgenthaler Private Equity. He currently serves on the corporate boards for seven life science Peering into companies and has achieved successful exits with numerous others. Previously, he was the president and CEO of Ribozyme Pharmaceuticals Inc., and has served as senior Bioscience’s vice president of research at SmithKline Beecham, vice president of discovery research at The Upjohn Company, and president of Colorado State University. Crystal Ball Larry Gold PhD is the founder, chairman of By Jeanne McAdara-Berkowitz, PhD the board, and CEO of SomaLogic. He founded NeXagen, which became NeXstar Pharmaceuticals and later merged with Gilead Sciences Inc.; and was a co-founder of Synergen, which was acquired by Amgen. He is also a professor at the University of Colorado at Boulder and served as the chairman of the Molecular, Cellular and Developmental Biology Department there. Gold serves on the boards of numerous bioscience companies and is a member of the American Academy of Arts and Sciences and the National Academy of Sciences.

Kyle Lefkoff is a founder and general partner of Boulder Ventures Ltd. In the course of his 26- year career as a venture capitalist, Lefkoff has invested in 60 Colorado companies, resulting in twelve IPOs and fifteen trade sales.

Patrick Mahaffy is the president and chief executive officer and a co-founder of Clovis Oncology. ith 10 years under the Colorado CAN YOU OFFER ANY PREDICTIONS ABOUT He previously founded Bioscience Association’s belt, it’s THE SCIENTIFIC PROBLEMS COLORADO’S Pharmion Corporation, a natural time to look back at our BIOSCIENCE COMMUNITY IS POISED TO which was acquired by Celgene Corporation, accomplishments and forward OVERCOME IN THE NEXT 10 YEARS? and also served as president and CEO Winto the future. We asked four Colorado of NeXagen and its successor, NeXstar bioscience industry veterans—Ralph “Chris” With a reluctance likely born from Pharmaceuticals. Mahaffy was formerly a Christoffersen of Morgenthaler Private Equity, experience, Gold and Mahaffy both demurred. vice president at the private equity firm E.M. Larry Gold of SomaLogic, Kyle Lefkoff of Perhaps they have seen too many predictions Warburg Pincus and Co. He serves on the Boulder Ventures, and Patrick Mahaffy of that missed the most significant breakthroughs boards of several bioscience companies and is a Clovis Oncology—for their perspectives on or, conversely, overstated the promise of trustee of Lewis and Clark College. what we should watch for in the decade to come. a product that ultimately never made it

22 2013/2014 BIOSCIENCE COLORADO class expertise in chemistry, which we “We’re also going to have.” “Third, CU is dominant in RNA biology see more and more and chemistry. In the next decade, we’re going to see a new class of drugs based integration between basic on miRNA and siRNA, much like the rise research and commercial of recombinant protein therapeutics in the 1970s and 80s, or monoclonal antibodies DO companies. Academics in the 90s.” DO Christoffersen sees regenerative are reaching toward medicine as another area with high potential for advancements in the coming health applications in decade. “Whether we’re talking about stem-cell therapy or other approaches, this YOUR ways that represent big is an area of rapidly growing scientific YOUR knowledge in our state. These technologies changes from when I aren’t quite ready for therapeutic prime time right now, but I think we’re going to started in science.” see a substantial growth in this space in the near future.” THING to market. “There are many exciting “More generally,” continued THING developments happening in Colorado, Christoffersen, “We are seeing a lot of but it’s impossible to predict what might work in our universities that is helping come out of our universities or companies, us understand more about how biological and which ones will be successful,” says mechanisms of action affect disease. I Mahaffy. Adds Gold, “No one knows think this is going to open up significant what’s really coming…there’s just no way opportunities for new therapeutic to know.” interventions at accelerated rates we’re not Lefkoff and Christoffersen were more used to seeing.” willing to speculate. “With the caveat that I am focused WILL EMERGING TECHNOLOGY CHANGE pretty exclusively on bioscience here in OUR APPROACH TO ASKING QUESTIONS the Boulder area,” says Lefkoff, “I think AND SOLVING TECHNICAL CHALLENGES? we have three areas of excellence that distinguish us from biotechnology clusters LG: The way scientific questions get asked in the rest of the US.” and answered has evolved dramatically “Number one,” he says, “has been the and will continue to do so. When I started opening of the Jennie Smoly Caruthers in science as an undergraduate, you could Biotechnology Building at CU, which define and run a single-day experiment and Reduce your costs and houses the BioFrontiers Institute. Now we every result would be important because Reduce your costs and have an integrated center for biotechnology no one had ever measured that before. You free up time by outsourcing HR that brings together disparate parts of the didn’t have to think so far into the future. free up time by outsourcing HR campus all in one place. CU has always Now we have to aim higher. It’s easier to • Leverage Our Health Benefits Buying Power • Leverage Our Health Benefits Buying Power been a rich mine of technology and I think do experiments now, but the thinking part and Save Money this will help the University in its long- is more difficult, the stakes are higher, and and Save Money term efforts to translate that resource into we’re spending a lot of public or investor • Aggregate Your HR Functions and Save Time commercial ventures.” money to get the answers. But on the other • Aggregate Your HR Functions and Save Time “Number two is the chemistry expertise hand, we’ve reached an interesting point • Transfer Your Risk from Employer Taxes, concentrated here,” Lefkoff continued. where we understand enough to formulate • Transfer Your Risk from Employer Taxes, “Chemistry-focused bioscience companies the hard questions, have real goals, and 401-k, Health Reform and Other Regulations are going to be increasingly important in solve what used to be difficult problems 401-k, Health Reform and Other Regulations the future because people have worked out but are now just technical challenges. much of the biology behind cancer and For example, at the UC Denver medical cardiovascular disease. If we have a target, school there’s a big push for personalized the next step is to work out the chemistry. medicine spearheaded by David Schwartz. Pharmaceutical companies want a Lipitor®, Information-driven medicine is happening not a Baycol, and to get there takes world- here in Colorado. Creative Business Resources Creative Business Resources 888-700-8512 | www.cbri.com BIOSCIENCE COLORADO 2013/2014 888-700-8512 | www.cbr23i.com PM: Speaking for ourselves at Clovis enterprise that can act as a true anchor to to be that kind of company, with technology Oncology, we’re definitely looking at questions keep startups here once they’re on their feet. that supports medical decision-making. But in new ways. I do think what we’re doing is BioFrontiers may represent the beginning of there are companies like DaVita, which is a truly next-generation oncology development, that anchor. phenomenally interesting company with plans looking at more subset populations with RCC: Growth will continue here both to take what they’re learning about managing companion diagnostics. It’s very much a 21st- in medical devices and in biotech/ patients on chronic dialysis and translate it to century oncology drug development paradigm. pharmaceuticals. I see a big potential other disease management areas. We’re going confluence developing between Fitzsimmons, to see more of that kind of initiative from WHAT WILL THE COLORADO BIOSCIENCE the Anschutz Medical Campus, and the small and large companies here. CLUSTER LOOK LIKE IN 10 YEARS? BioFrontiers Institute. Collaboration between these three entities has tremendous WHAT DO YOU SEE STANDING IN THE WAY OF PM: We’ll continue to have a strong opportunity to create a biotech cluster that will FUTURE SCIENTIFIC INNOVATION, HERE IN bioscience community here, although it may be best in nation. COLORADO AND MORE BROADLY? never be what Boston, San Francisco, or LG: Reflecting on the early years of bioscience San Diego have. But we have a good base of here, I look back at NeXstar, which was PM: We continue to lack a big, anchoring technologies and university resources, a group sold to Gilead for its one drug…and at the presence here—a big biotech or big pharma of committed scientists, and well-developed, many other companies started here that were company like Genentech in San Francisco— entrepreneurial managers, and that will acquired for their single drugs, and it’s clear that attracts and trains talent who goes on to continue to give rise to new companies. I think that it’s hard to build a sustainable, single- found small companies that stay in the area. the big news to watch will be what impact CU product pharmaceutical company because The University system remains an asset here Boulder’s BioFrontiers Institute will have on the cost of taking a drug all the way through that serves as the basis for new companies, but the local industry cluster. They will provide development is so high, and so is the failure the challenge for us so far is that companies compounds and technologies to foster new rate. that have done well here get acquired and startups. We’ve seen a successful startup Now I see lots of companies with what move away. If we were lucky enough to grow community in biotech over the past decade, look like sustainable platforms growing here. such an anchor organically or recruit one in, it but we haven’t yet created a sustainable Of course I believe Somalogic has the chance would be a real boost to the industry here.

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[email protected] • (970) 491-7157 www.engr.colostate.edu/sbme

SCHOOL OF BIOMEDICAL ENGINEERING

24 2013/2014 BIOSCIENCE COLORADO I also worry about funding. Current Setting the Standard for Medical Waste Disposal cutbacks in government grant funds are chilling academic research, which of course Celebrating 21 Years of Service is so important to the biotech industry. The simultaneous contraction of venture capital, Convenient, timely, a ordable service. particularly with respect to bioscience, No ne print or hidden agendas. makes it very hard to finance innovation Gold Star Award and A+ rating with the today. It’s particularly hard for individuals BBB 2008-2012. who are otherwise terrifically capable but Local, woman owned company and lack a track record to access venture capital industry experts. or grant money. This is true in Colorado and Join your fellow CBSA members and elsewhere in US, and what is interesting about become a partner to reduce our carbon it is that funds are drying up right as we are footprint. Introducing Colorado’s rst entering this golden age of biology. We know environmental & sustainable disposal so much more about the mechanisms behind solution. disease than ever before. It’s my hope that Together we can make a di erence! enough companies will succeed here to re- attract investors to our state and reinvigorate 3131 Oakland St. Aurora, CO 80010 [email protected] funding. 303 794-5716 Fax: 303 763-2339 www.coloradomedicalwaste.com KL: Threats to innovation? I don’t foresee any (laughs). Thein fthingo@co lis,ora Boulderdomedica haslwa stgrowne.com into a self-sustaining entrepreneurial ecosystem Supporting the that attracts talent and capital. There are a lot of resources and technology, it’s a beautiful biotech community place to live, and people want to be here. And it’s not just biotech—the ecosystem is The University of Colorado BioFrontiers economically diverse. So at least in Boulder, Institute offers the biotech community I don’t see any threats to biotechnology access to research facilities and expertise, innovation as a whole. including: RCC: We have a continuing need to increase infrastructure to help encourage companies to • Next-generation sequencing start here or move here. Developing space for • Functional genomics clinical trials organizations, manufacturing • Microscopy and high-content imaging facilities, and other resources will help build • Mass spectrometry and proteomics a critical mass of infrastructure, dollars spent, • High-throughput screening for drug discovery and money invested. That will be useful • NMR spectroscopy not just for startups and established local companies, but will also attract others to http://biofrontiers.colorado.edu/impact come and settle here. LG: The thing I’ve just finally learned in the last five years is that the problems you think are going to be solved technically will be solved technically. The NIH budget shrinks and grows, funding comes and goes, but CBSA2013-BioFrontiers(final).indd 1 3/20/13 4:08 PM through the efforts of academics, industry, Impactful Editorial Media Placements government, investors, and even small amateur inventors, the knowledge base will grow. So I don’t see the daily worries about funding, tax breaks, etc. as true threats. To me, the real threats are societal. As a species, we are capable of enormous denial, especially for technologies that are disruptive Maggie Chamberlin Holben, APR or that have to unsettle existing businesses or www.Twitter/DenverPR social paradigms. Doing science with optimism and hope is easy; getting it scaled up so that it Local • Trade • National • Social Media Strategies helps people is the hard problem. [email protected] 303.984.9801

BIOSCIENCE COLORADO 2013/2014 25 Webb-WaringBiomedical Boettcher Investigators Research Program

The Webb-Waring Institute was founded in 1924 by Dr. Gerald B. Webb and later directed by Dr. James J. Waring. For over 80 years, the organization contributed to the advancement of biomedical research by engaging in basic and clinical research and training research sci- entists. In 2008, the Webb-Waring Institute became a part of the Uni- versity of Colorado and is now known as the Webb-Waring Center. Class of 2012 The Boettcher Foundation was entrusted with the stewardship of the Webb-Waring Foundation's assets. Through an innovative agreement between the Boettcher Foundation, the Webb-Waring Foundation and the University of Colorado, a funding area was established at the Boettcher Foundation that supports the work of early-career investiga- tors in the biomedical sciences in Colorado.

Please visit our website to learn more about the exciting research be- ing conducted by our 14 Boettcher Investigators and the class of 2013 announcement. www.boettcherfoundation.org

Harald Junge, Ph.D., Assistant Professor of Molecular, Cellular, and Developmental Biology University of Colorado at Boulder Investigating Retinal Vascular Development and Disease

Matthew Kennedy, Ph.D., Assistant Professor of Pharmacology University of Colorado – Anschutz Medical Campus Investigating Molecular Mechanisms of Alzheimer’s Pathology

Chad G. Pearson, Ph.D., Assistant Professor of Cell and Developmental Biology University of Colorado – Anschutz Medical Campus 26 2013/2014 BIOSCIENCE COLORADO Investigating Organization of the Microtubule Cytoskeleton for Cell Division and Signaling Webb-WaringBiomedical Boettcher Investigators Research Program

The Webb-Waring Institute was founded in 1924 by Dr. Gerald B. Webb and later directed by Dr. James J. Waring. For over 80 years, the organization contributed to the advancement of biomedical research by engaging in basic and clinical research and training research sci- entists. In 2008, the Webb-Waring Institute became a part of the Uni- versity of Colorado and is now known as the Webb-Waring Center. Class of 2012 The Boettcher Foundation was entrusted with the stewardship of the Webb-Waring Foundation's assets. Through an innovative agreement between the Boettcher Foundation, the Webb-Waring Foundation and the University of Colorado, a funding area was established at the Boettcher Foundation that supports the work of early-career investiga- tors in the biomedical sciences in Colorado.

Please visit our website to learn more about the exciting research be- ing conducted by our 14 Boettcher Investigators and the class of 2013 announcement. www.boettcherfoundation.org

Harald Junge, Ph.D., Assistant Professor of Molecular, Cellular, and Developmental Biology University of Colorado at Boulder Investigating Retinal Vascular Development and Disease

Matthew Kennedy, Ph.D., Assistant Professor of Pharmacology University of Colorado – Anschutz Medical Campus Investigating Molecular Mechanisms of Alzheimer’s Pathology

Chad G. Pearson, Ph.D., Assistant Professor of Cell and Developmental Biology University of Colorado – Anschutz Medical Campus BIOSCIENCE COLORADO Investigating 2013/2014 Organization of the Microtubule Cytoskeleton for Cell Division and Signaling 27 Colorado By the Numbers: 2011-2012 Review

2011 Financings Name Close Date city Amount $M round Class Lead Investor Industry Type 2C Tech Corp 3/1/11 Longmont undisclosed Seed BDEGP Grant Biotech/Pharma Able Planet Inc. 12/30/11 Wheat Ridge $1.00 Later Stage Medical Device/Diagnostic Accera 1/3/11 Broomfield $11.00 Series D Biotech/Pharma Accera Inc. 10/10/11 Broomfield $8.78 Debt/Non-Equity Biotech/Pharma ADA Technologies, Inc. 7/12/11 Littleton $70.00 Contract U.S. Army Biotech/Pharma AktiVax Inc. 8/17/11 Aurora undisclosed Seed Round High Country Venture Medical Device/Diagnostic AmideBio 5/10/11 Aurora $0.58 Biotech/Pharma Ampio Pharmaceuticals, Inc 12/21/11 Greenwood Village $9.50 Secondary Biotech/Pharma Ampio Pharmaceuticals, Inc 4/19/11 Greenwood Village $12.70 Private Placement common stock Biotech/Pharma ARCA biopharma 4/18/11 Aurora $3.00 Debt/Non-Equity Biotech/Pharma Ariel Pharmaceuticals Inc. 9/29/11 Broomfield $6.00 First Round Undisclosed Venture Investor(s) Biotech/Pharma BioAMPS International 3/1/11 Aurora undisclosed Seed BDEGP Grant Biotech/Pharma BioAMPS International 2/27/11 Aurora $1.48 Phase 2 U.S. Office of Naval Research Biotech/Pharma Biodesix Inc. 7/18/11 Boulder $20.00 Series D Medical Device/Diagnostic Biodesix Inc. 6/21/11 Boulder $10.25 Later Stage Medical Device/Diagnostic BiOptix Diagnostics Inc. 3/18/11 Boulder $9.00 Series B Nanotechnologies (“RUSNANO”) Medical Device/Diagnostic Cell Point LLC 3/30/11 Centennial $2.20 Later Stage Biotechnology Therapeutics Clarimedix Inc. 3/1/11 Aurora undisclosed Seed BDEGP Grant Biotech/Pharma Clarimedix Inc. 6/23/11 Aurora undisclosed First Round High Country Venture Biotech/Pharma Clarimedix Inc. 12/31/11 Aurora undisclosed Corporate Johnson & Johnson Development Corp. Biotech/Pharma Clinipace Worldwide Inc. 10/5/11 Boulder $15.00 Series C Morgan Stanley Expansion Capital Biotech/Pharma Clovis Oncology Inc. 5/25/11 Boulder $20.00 Debt/Non-Equity Domain Associates LLC Biotech/Pharma Clovis Oncology Inc. 11/16/11 Boulder $130.00 Public Investment Biotech/Pharma Cytologic Inc. 3/1/11 Boulder undisclosed Seed BDEGP Grant Biotech/Pharma EndoShape Inc. 4/22/11 Boulder $3.50 Series B Medical Device/Diagnostic Flashback 8/1/11 Longmont undisclosed Seed CID4 Medical Device/Diagnostic Government of Canada/ FONEMED 3/17/11 Colorado Springs $2.40 Medical Device/Diagnostic Atlantic Innovation Fund (AIF) Gevo 3/16/11 Englewood $123.30 IPO BioFuels Inviragen, Inc. 8/15/11 Fort Colllins $3.00 Grant National Institute of Allergy and Biotech/Pharma Infectious Diseases Mbio Diagnostics, Inc 7/20/11 Boulder $5.20 Award NIH Medical Device/Diagnostic MicroPhage Inc. 3/4/11 Longmont $6.45 Debt/Non-Equity Medical Device/Diagnostic MicroPhage Inc. 10/7/11 Longmont $6.00 Corporate Cardinal Health Medical Device/Diagnostic Miragen Therapeutics Inc. 10/18/11 Boulder $45.00 License Agreement Biotech/Pharma miRagen Therapeutics, Inc 8/25/11 Boulder $0.72 Small Business Innovation The National Heart Lung and Blood Biotech/Pharma Reaseach Grant Institute (NHLBI)/division of NIH Mosaic Biosciences Inc. 3/1/11 Aurora undisclosed Seed BDEGP Grant Biotech/Pharma Mosaic Biosciences Inc. 7/7/11 Aurora $1.03 Seed Round Biotech/Pharma OPX Biotechnologies 7/7/11 Boulder $36.50 Series C Biotech/Pharma Otologics LLC 8/9/11 Boulder $0.50 Debt/Non-Equity Medical Device/Diagnostic PanTheryx 3/28/11 Boulder $1.00 Series A Biotech/Pharma Peptivir Inc. 3/1/11 Aurora undisclosed Seed BDEGP Grant Biotech/Pharma Pharmaca Integrative 3/1/11 Boulder Later Stage Biotech/Pharma Pharmacy Inc. PharmaJet Inc. 3/31/11 Golden $5.00 Later Stage Medical Device/Diagnostic PharmaJet Inc. 11/17/11 Golden $4.00 Private Equity Medical Device/Diagnostic PharmaJet Inc. 11/11/11 Golden $0.10 Grant Bill & Melinda Gates Foundation Medical Device/Diagnostic Precision Biopsy 3/1/11 Aurora undisclosed Seed BDEGP Grant Medical Device/Diagnostic Precision Biopsy 11/8/11 Aurora $2.50 Series A Allied Minds Medical Device/Diagnostic Sharklet Technologies Inc. 6/21/11 Aurora $1.20 Grant National Institutes of Health Medical Device/Diagnostic Sinopsys Surgical Inc. 3/9/11 Boulder $0.41 Seed Round Medical Device/Diagnostic St. Renatus LLC 12/31/11 Fort Collins $3.50 Series A Biotech/Pharma Surefire Medical Inc. 7/6/11 Westminster $6.10 Series A Partisan Management Group Medical Device/Diagnostic Suvica Inc 03/01/12 Boulder undisclosed Seed BDEGP Grant Biotech/Pharma ValveXchange 7/7/11 Greenwood Village $3.50 Equity Investment CryoLife Medical Device/Diagnostic VetDC Inc. 6/22/11 Fort Collins undisclosed Seed CID4 Biotech/Pharma ZeaChem Inc. 10/25/11 Lakewood $19.00 Series C Birchmere Ventures BioFuels

28 2013/2014 BIOSCIENCE COLORADO Larimer Weld

Boulder Broomfield Gilpin Adams Denver Clear Creek Arapahoe Jefferson

Douglas

El Paso 2011 2012

COLORADO

2012 Financings Name Close Date city Amount $M round Class Lead Investor Industry Type Accelr8 04/23/12 Denver $35.00 Debt/Non-Equity Medical Device/Diagnostic Accelr8 /Denver Health 05/15/12 Denver $2.00 Grant Defense Medical Research and Medical Device/Diagnostic Development Program (DMRDP) Accera Inc. 07/18/12 Broomfield undisclosed Later Stage Nestle S.A. Biotech/Pharma AktiVax Inc. 03/21/12 Aurora $0.10 Debt/Non-Equity Medical Device/Diagnostic AmideBio 03/01/12 Louisville undisclosed Seed BDEGP Grant Biotech/Pharma Biodesix Inc. 08/29/12 Boulder $12.00 Later Stage Medical Device/Diagnostic Breakthrough Products Inc./ 05/21/12 Denver $3.00 First Round JUMP Investors Biotech/Pharma UrgentRX Cell Point LLC 05/24/12 Centennial $2.80 Later Stage Biotech/Pharma Cerapedics Inc. 07/12/12 Westminster $19.00 Later Stage MedImmune Ventures Biotech/Pharma Carbo Analytics LLC 03/01/12 Fort Collins undisclosed Seed BDEGP Grant Medical Device/Diagnostic Crestone Inc 03/01/12 Boulder undisclosed Seed BDEGP Grant Biotech/Pharma Evolutionary Genomics Inc. 06/25/12 Lafayette $0.44 Later Stage Biotech/Pharma Flashback 03/01/12 Boulder undisclosed Seed BDEGP Grant Medical Device/Diagnostic InDevR LLC 02/23/12 Boulder $5.80 Grant Defense Advanced Research Medical Device/Diagnostic Projects Agency (DARPA) Inviragen Inc. 01/23/12 Fort Collins $0.31 Second Round Biotech/Pharma Lanx Inc. 09/10/12 Broomfield $8.69 Later Stage Medical Device/Diagnostic Mbio Diagnostics Inc., 10/31/12 Boulder $3.80 Medical Device/Diagnostic Miragen Therapeutics Inc. 04/10/12 Boulder $20.00 Second Round Remeditex Ventures LLC Biotech/Pharma Onkure Inc 03/01/12 Longmont undisclosed Seed BDEGP Grant Biotech/Pharma PharmaJet Inc. 10/12/12 Golden $2.00 Debt/Non-Equity Medical Device/Diagnostic Shape Opthalmics LLC 03/01/12 Aurora undisclosed Seed BDEGP Grant Medical Device/Diagnostic Sharklet Technologies Inc. 12/07/12 Aurora $2.00 Second Round Altria Group Inc. Medical Device/Diagnostic Siva Therapeutics 12/03/12 Boulder $0.35 Angel Biotech/Pharma Sophono Inc. 08/14/12 Boulder undisclosed Seed BDEGP Grant Medical Device/Diagnostic Sophono Inc. 08/14/12 Boulder $7.00 First Round Wexford Capital Medical Device/Diagnostic St. Renatus, LLC 01/09/12 Fort Collins $3.50 Angel Biotech/Pharma Suvica Inc 03/01/12 Boulder undisclosed Seed BDEGP Grant Biotech/Pharma Ventria Bioscience/ 06/04/12 Fort Collins $1.50 Grant Small Business Innovation Biotech/Pharma InVitria Division Research Program (SBIR) VetDC, Inc. 11/29/12 Fort Collins $1.50 Private financing Biotech/Pharma ZeaChem Inc. 10/29/12 Lakewood $25.00 Series C ITOCHU Corporation BioFuels ZeaChem Inc. 02/23/12 Lakewood $40.00 Grant USDA’s National Institute of BioFuels Food and Agriculture (NIFA)

BIOSCIENCE COLORADO 2013/2014 29 2011-2012 Acquisitions

Company City Acquired by City Amount CaridianBCT Lakewood TerumoBCT Tokyo, Japan 2600 M Baxa Englewood Baxter Deerfield, IL 380 M Medivance Louisville C. R. Bard, Inc. Murray Hill, NJ 250 M

Allos Therapeutics Westminster Spectrum Pharmaceuticals Henderson, NV Stock Macleod Pharmaceuticals Fort Collins Neogen Corporation Lansing, MI Stock Aegis Analytical Corp. Lafayette Accelrys, Inc. San Diego, CA 30 M MedEfficiency Wheat Ridge Derma Sciences Princeton, NJ 14.5 M

2012 2011 Synthes, Inc. Monument Johnson & Johnson New Brunswick, NJ 19.7 B

2011-2012 New Companies

Company City Industry Type Acertara Acoustic Laboratories Longmont Medical Device/Diagnostic Flashback Boulder Medical Device/Diagnostic Great Lakes Pharmaceuticals* Denver Biotech/Pharma InDevR Boulder Biotech/Pharma Mosaic Biosciences Aurora Biotech/Pharma Oberon FMR Aurora Biotech/Pharma PharmaJet Golden Medical Device/Diagnostic PolyNew Golden/ Aurora BioFuels Sharklet Technologies* Aurora Medical Device/Diagnostic Surefire Medical* Westminster Medical Device/Diagnostic SuviCa Boulder Biotech/Pharma VetDC Fort Collins Biotech/Pharma

Aurora Oncology, Inc. Aurora Biotech/Pharma Cetya Therapeutics, Inc. Fort Collins Biotech/Pharma Colorado Micro Tech Fort Collins Biotech/Pharma Double Helix, LLC Boulder Biotech/Pharma

2012 2011 Hyperion Labs, LLC Fort Collins Medical Device/Diagnostic MonImmune Therapeutics Fort Collins Biotech/Pharma OpTmune Boulder Biotech/Pharma

30 2013/2014 BIOSCIENCE COLORADO the Institute Colorado BioScience

The Institute provides these key service and programs meeting the needs of the following populations:

Science Education Providing teachers with practical knowledge and experience to enhance their content skill and classroom practice, especially related to Science, Technology, Engineering and Mathematics (STEM).

Professionals Providing programs for experienced researchers, entrepreneurs, and business leaders to build businesses and advance their careers in the bio- science industries.

Workforce Development Providing classes, trainings programs and internships as a form of workforce recruitment and development.

Secondary Students (9-12) Providing students with opportunities to explore careers in biotechnology and associated industries.

Community Creating broader awareness of the industry’s impact through partnerships with other organizations.

Make your tax-deductible gift now! www.CoBioInstitute.org

The Colorado BioScience Institute (the Institute) is a 501(c)3 non-profit that provides educational activities and opportunities for individuals and companies, students and educators related to the bioscience industry in Colorado.

BIOSCIENCE COLORADO 2013/2014 31 Bioscience Discovery Evaluation Grant Program Return on Investment Fiscal Year 2006-07 to 2011-12

Total Number of Grants 203

145 Proof of Concept (POC) Grants 7,861,561

36 Early Stage Company (ESC) Grants $5,762,200

12 SBIR/STTR he Bioscience Discovery Evaluation Grant Program $755,073 (BDEGP) was created in 2006 by the Colorado Gener- al Assembly to grow the bioscience industry in the state. 10 Infrastructure Grants The BDEGP provides gap funding to advance promising $8,379,743 researchT from Colorado’s outstanding research institutions into the market place. The bioscience industry in Colorado is strengthened by such efforts, resulting in long-term job creation and company formation. Approximately $22 million from the BDEGP Cash Fund has been granted and will garner at least an equal amount in matching funds (excluding Commercialization Infrastructure grants). The BDEGP Cash Fund was appropriated $5,499,321in fiscal year 2010-11 and $4,320,967 in fiscal year 2011-12. The program’s statute requires an allocation of at least 30% of the funds to Proof of Concept grants, 30% of the funds to Early-Stage Company grants, and up to 40% of the funds to Commercialization Infrastructure.

32 2013/2014 BIOSCIENCE COLORADO Research Institutions

Proof of Concept (POC) Grants Awarded:

1 Bonfils Blood Center Foundation

9 Colorado School of Mines

42 Colorado State University

23 National Jewish Health

62 University of Colorado

5 University of Denver

3 University of Northern Colorado

Complete Economic Impact

34 new companies, 302 direct jobs

1,063 indirect jobs (302 x 3.52*)

Average bioscience sector salary: $82,000*

Total payroll for all jobs (direct and indirect): $87.1 million ($82,000 × 1,063)

Additional investment: $112 million (matching $17.3 million & follow-on capital $95 million)

Leverage of 5 x state investment: ($22 million to $112 million)

Infrastructure Grants

BioFrontiers Institute at the University of Colorado-Boulder (formerly Colorado Initiative in Molecular Biotechnology)

Colorado Center for Drug Discovery (C2D2) at Colorado State University

Colorado Institute for Drug, Device, and Diagnostic Development (CID4)

University of Colorado-Drug Development Center High Throughput Screening Core

*BATTELLE/BIO STATE INITIATIVES REPORT

BIOSCIENCE COLORADO 2013/2014 33 PROOF-OF-CONCEPT Investigator: Stephen Boyes, Ph.D.

GRANTS 2012 -2013 Title: Polymer Modified Nanoparticles as Contrast Agents for the Non-invasive Measurement of pH in vivo

Research: For many years researchers have known the importance of the extracellular pH (pHe) in solid tumors in relation to cancer morbidity and mortality. A low pHe has been identified as an important factor in producing more aggressive cancer phenotypes and causing metathesis of the primary carcinoma, both of which are leading causes of cancer morbidity and mortality. As such, the ability to measure the pHe of solid tumors using non-invasive and accurate techniques that also provide high spatiotemporal resolution has become increasingly important and is of great interest to clinicians. Despite this interest, there is currently no clinical method available for the in vivo determination of pHe in tumors and, despite the existing research in this area, in vivo applications have been limited. This research seeks to prepare polymer modified hybrid Gadolinium-Iodine nanoparticles which will allow for the development of a novel class of targeted, pH responsive contrast agents for magnetic resonance imaging, providing high sensitivity and specificity in the non-invasive in COLORADO SCHOOL OF MINES vivo imaging of pHe.

Impact: Contrast agents based on nano-particles offer many Investigator: Melissa Krebs, Ph.D. advantages over traditional small molecule contrast agents, such as improved specificity if modified with molecular targets, Title: Biopolymer Hydrogels for the Controlled, Localized enhanced sensitivity, and improved retention times. In addition, Delivery of Therapeutic Antibodies the ability to surface modify the nano-particle contrast agents with multi-functional, biocompatible polymers introduces the capacity Research: Glioblastoma is an extremely aggressive brain cancer to control surface functionality and biodistribution. As such, the with poor patient prognosis because current methods include development of a pH responsive magnetic resonance imaging radiation which has effects surrounding tissue and some anti- contrast agent, based upon polymer modified nano-particles, that cancer drugs which cannot make it through the blood/brain provides the ability to accurately and non-invasively determine barrier. This research focuses on using a promising alternative tumor pHe in vivo has the potential to dramatically improve the approach to treating this disease with the injection of an antibody- detection and diagnosis of cancer and significantly improve the laden biodegradable hydrogel, which would release antibody to therapeutic outcome and quality of life for patients. the tumor site in a localized, controlled manner over a sustained period of time.

Impact: The current cost of treatment for a single glioblastoma patient is at least $50k per year with a very high mortality rate. The goal of these studies is to develop a new class of biodegradable delivery devices for bioactive antibodies, with the primary focus on treating glioblastomas. In the future, one could also envision encapsulating both antibody and a chemotherapeutic or radioactive drug within the hydrogel for dual drug delivery at the tumor site. Further, the engineered hydrogels will serve as a platform technology for use in other clinical applications where the controlled delivery of antibody would be beneficial– including other types of cancer as well as in regenerative medicine applications. Initially the market could be targeted to glioblastoma patients (~4100 new patients each year in the U.S.), but ultimately could be much larger and directed at many other problems, as this is a platform technology.

34 2013/2014 BIOSCIENCE COLORADO COLORADO STATE UNIVERSITY

Investigator: Steven Dow, Ph.D. Investigator: Christopher Orton, DVM, Ph.D.

Title: Novel Non-Adjuvant Drugs for Enhancing Vaccine Efficacy Title: Phase I Clinical Trial for MitralSeal® Transcatheter Mitral Valve Implantation in Dogs Research: The goal of this project is to evaluate previously approved drugs for their monocyte migration inhibitor (MMI) Research: This project aims to address an unmet need: catheter- potential and use as novel vaccine enhancing agents. Inflammatory delivered mitral valve replacement devices for animal and monocytes potently suppress vaccine responses; using MMI drugs human heart surgery. Through a phase I veterinary clinical trial, to block this activity can markedly improve vaccine responses. these studies will provide a novel step toward FDA approval by This project aims to identify drugs that can function as effective extending traditional pre-clinical studies in normal animals to MMIs and assess their impact on boosting immune responses to animals with heart conditions needing mitral valve repair. These vaccination and the effectiveness of MMI delivery on vaccine studies will demonstrate the feasibility and performance of the responses. device, and evaluate the physiological and biological response.

Impact: The availability of already approved drugs that could Impact: Heart valve surgery is the second most commonly broadly enhance the efficacy of existing vaccines would have a performed heart surgery in Western countries and artificial heart rapid impact on the vaccine field, including both prophylactic and valves are a $1.2 billion market worldwide. Surgery on the mitral therapeutic vaccines. These could be used to enhance not only valve represents about one-third of all heart valve surgeries. commonly used vaccines that elicit suboptimal immunity (e.g., Catheter-delivered (transcatheter) valve devices are projected to influenza, shingles, pneumococcus vaccines) but also to increase offer the largest growth opportunity in the U.S. and European heart the efficacy of vaccines that, to date, have failed to produce valve device market in the next five years. This project will work sufficient efficacy for approval and widespread use (e.g., HSV2, with a small startup medical device company, Avalon Medical, to cancer vaccines). Recent Colorado State University startup, further develop this technology. MonImmune Therapeutics, is further developing the technology and anticipates launching clinical trials within a few years. Investigator: Robert M. Williams, Ph.D.

Investigator Greg Miknis, Ph.D. Title: Class 1 Isoform Selective HDACi’s: Scale-up and Efficacy Studies in Autoimmunity and Cancer Title: New Methods to Prepare Peracids Research: The goal of this project is to establish the foundational Research: This project aims to improve the chemical synthesis areas of an early stage drug development program based on a and quantitation of the active component in a recently developed naturally occurring molecule known as Largazole. This project anti-microbial disinfectant solution through novel approaches in will focus on analytical studies to demonstrate efficacy in cell- synthetic chemistry. Project work should result in new methods to based and rodent models, and interrogate the pharmacokinetic prepare, characterize and evaluate the biological properties of new properties of largazole analogs. Laragazole is a histone deacetylase alpha-keto peracids inhibitor and demonstrates isoform selectivity and high potency with potential drug applications in cancer, autoimmune, blood, Impact: Composition of matter and novel method of preparation neurodegenerative, and cardiac diseases. This study will provide patents developed at CSU will support commercialization of alpha- the information necessary to initiate human phase I clinical trials keto peracids, and allow for production of commercial quantities. and leverage the broad-based clinical utility of largazole analogs in This alpha-keto peracid solution has demonstrated improved anti- commercial drug development. microbial activity and has applications in surface disinfection in healthcare settings, disinfection/sterilization of re-usable medical Impact: These studies in both cancer and autoimmunity position device products, implantable medical devices, and wound care. the technology to begin drug development that will target very large markets segments. CSU startup CETYA Therapeutics, Inc. was founded to begin the commercialization process of the largazole analog technology. The largazole analog technology holds potential in treating and relieving multiple sclerosis symptoms as well as numerous other autoimmune diseases.

BIOSCIENCE COLORADO 2013/2014 35 NATIONAL JEWISH HEALTH

Investigator: Erwin Gelfand, M.D. Investigator: Hong Wei Chu, M.D. and Gongyi Zhang, Ph.D.

Title: Targeting PIM1 Kinase in the Treatment of Allergic Title: SPLUNC1: a novel therapy of infection and inflammation Diseases Research: Respiratory bacterial and viral infections continue Research: Unlike many other diseases, the treatment of to pose a significant challenge in healthcare, cost billions of allergic disease has had limited success beyond the use of dollars, and are the major causes of acute exacerbations of lung corticosteroids. It is therefore critical to develop novel sources diseases including asthma, chronic obstructive pulmonary disease of therapy. This research group has shown that the enzyme and cystic fibrosis that affect more than 30 million Americans. PIM kinase plays an important role in allergic diseases. With There is an increasing trend of antibiotic resistance, and no chemistry expertise provided by collaborators at the Colorado effective antiviral therapies are available. Thus, it is imperative to State University and the University of Colorado, the initial key develop more effective therapies to treat infections and disease objectives of this project are to generate and evaluate a series of exacerbations This project intends to develop a novel treatment novel PIM kinase inhibitors in experimental models of allergic for infection and exaggerated inflammation in lung diseases disease. These objectives include inhibitors with a product using a secretory protein called SPLUNC1 and bioengineering profile of safety, oral or inhalational delivery, and efficacy as approaches. primary or adjunctive therapy. Impact: This work could lead to the development of a novel Impact: This work represents a 2-part approach to develop novel therapy for lung bacterial or viral infection. PIM1 kinase inhibitors as potential therapeutics for the treatment of allergic diseases. Investigator: Karin Pacheco, M.D. and Vijaya Nagabhushanam, M.D, Ph.D. Investigator: Joseph Lucas, Ph.D. Title: Development and validation of diagnostic assays for metal Title: Cdk6 as a Breast Cancer Biomarker – Preclinical and bone cement allergy in joint implant failure. Exploratory and Validation Phase Research: Joint replacements are a common procedure in the Research: This research team reported that many breast tumors US: at present, about one million hip and knee replacements are have reduced amounts of the cdk6 kinase and proposed that its performed annually. Of these, it is estimated that 10% will fail and loss promoted tumor growth. Cdk6 modulates the expression of ultimately require revision. Allergic reactions to implant materials genes encoding steroid metabolic enzymes (SMEs) responsible for (metals and bone cement components) are being increasingly estrogen synthesis in breast cells. They propose to develop a breast recognized as contributors to failure as well. Building on National tumor diagnostic assay based on the level of cdk6 and SMEs. Jewish expertise in allergies and working with several Denver- based orthopedic groups, this project aims to create a blood- Impact: The proposed work could lead to diagnostic tools for based tests to diagnose various metal allergies in patients with identification and classification of breast tumors. The commercial orthopedic joint failures. potential of the technology is broad and could extend to other cancers whose growth is affected by steroids, such as prostate, Impact: This work would lead to the development of a diagnostic ovarian, and some lung cancers. assay for metal and bone cement allergy in joint implant failure.

36 2013/2014 BIOSCIENCE COLORADO Investigator: Michael Strong, Ph.D. and Charles Daley, M.D.

Title: Development of a Novel Molecular Diagnostic for Nontuberculous Mycobacterial Infections

Research: Nontuberculous mycobacteria (NTM) are an increasingly recognized bacterial pathogen in the United States. The dominant form of NTM infections occur in the lung, causing a variety of respiratory problems. NTM infections are believed to be acquired in the environment, instead of being transmitted person to person like Mycobacterium tuberculosis. This project builds on computational, genomic, and molecular expertise to optimize sets of distinguishing genomic biomarkers for the rapid and accurate diagnosis of NTM infections. UNIVERSITY OF COLORADO BOULDER BIOFRONTIERS INSTITUTE Impact: This work will lead to the development of a diagnostic test for Nontuberculous Mycobacterial Infections. This product will enable physicians to accurately diagnose if a patient’s symptoms Investigator: Hubert Yin, Ph.D. are due to infecting NTM, and if so, inform the physician of diagnostic classifiers including species, strain, and other clinically Title: Strengthening CU IP around therapeutics for treating important signatures, so that the most effective drug regiment can chronic pain and improving the clinical utility of opiods be prescribed. Research: Generation and evaluation of novel therapeutics derived from intermediates of existing compounds.

Impact Identification of non-opioid, non-addictive therapeutics to treat chronic pain and enhance the clinical efficacy of existing opioids.

Investigator: Leslie Leinwand, Ph.D. and Brooke Harrison, Ph.D.

Title: Fatty acid induced cardioprotection and treatment of pathological cardiac hypertrophy

Research: Evaluate a novel combination of fatty acids in protecting the heart from subsequent cardiac insult and as a treatment administered after cardiac insult.

Impact: Preclinical validation of a prescription therapeutic or a dietary supplement capable of promoting beneficial heart growth.

Investigator: Zhongping Tan, Ph.D. and Charles Dinarello, M.D.

Title: Chemical Glycoengineering of Insulin for Type 2 Diabetes Treatment

Research: Prepare and evaluate stable, long-acting insulin analogs for the treatment of type 2 diabetes.

Impact: Validation of chemical glycoengineering technology and development of next-generation antidiabetic medications.

BIOSCIENCE COLORADO 2013/2014 37 UNIVERSITY OF COLORADO DENVER

Investigator: James Chen, S.Y. Ph.D. and John Carroll, M.D.

Title: Three-Dimensional PCI Planner System

Research: Build a mobile, cloud based interface for 2D to 3D transformation of vascular images for planning percutaneous procedures.

Impact: Reduce time and complications associated with stent installation in cardiac arteries, and improve outcomes through enablement of a cloud-based registry of surgical cases and images from those cases.

Investigator: Robert C. Doebele, M.D. and Marileila Garcia, Ph.D. Investigator: Brian Reid, Ph.D. and Timothy McKinsey, Ph.D.

Title: Methods for Diagnosis and Treatment of Cancer Title: Small Molecule Therapies for Prevention of Cardiomycocyte Hypertrophy Research: Determine the feasibility of an existing experimental drug in treating a new molecular subtype of cancer, detected with Research: Evaluate potential drugs for a type of heart-failure, in a a novel test invented at Anschutz Medical Campus. highly robust drug screen.

Impact: Clinical validation of a new genetic defect found in cancer Impact: Rapidly enable clinical prioritization of experimental heart that will guide the use of personalized therapy. failure drugs.

Investigator: Douglas Graham, Ph.D., M.D. Investigator: Robin Shandas, Ph.D. and Michael Zimkowski

Title: Development of Axl-Fc for Oncology Applications Title: Shape memory polymer integrated surgical mesh for hernia repair application. Research: A novel biologic agent will be evaluated for its ability to augment standard cancer chemotherapies and reduce tumor Research: Evaluate surgical use and durability of an improved burdens in animals. hernia patch.

Impact: Improve survival and quality of life in various cancer Impact: Reduce complications and failures of existing hernia patients. patches enabling more effective and faster surgeries.

38 2013/2014 BIOSCIENCE COLORADO EARLY STAGE COMPANY AWARDS 2012-2013 KromaTiD, Inc. This grant is dedicated to the product launch of novel research tools Aurora Oncology, Inc. for cancers, developmental disorders and other genetic diseases. KromaTiD’s unique assays provide disease researchers with the tools This grant expands research for a recently funded SBIR they need to understand the root causes of genetic disease and to project entitled DT-EGF Toxic Fusion Protein for Treatment develop new companion diagnostic tests. BDGEP will support sales of Bladder Cancer. The funds will assist the company in and marketing of KromaTiD’s chromosome imaging assays, including expanding the number of patient samples that can be put newly hired sales and applications development professionals. into immunocompromised mice, and will improve the dose www.kromatid.com response and timing studies in the cell line. Grant funds support the development of a comprehensive business plan that can be used to apply for SBIR phase II funding, and FDA Siva Therapeutics Inc consultations on human phase I and II trials in preparation for an IND application. This grant funds a project entitled ‘Smart Polymers for Improved Photothermal Cancer Therapy: Optimized Surface Chemistry for Increasing Retention of Precision Gold Nanorods in Solid Tumors.’ BaroFold, Inc. Siva has entered into an exclusive license to patented polymer technology developed in the laboratory of Professor Stephen Boyes This grant funds the evaluation of PreEMTTM high pressure in the Department of Chemistry and Geochemistry at the Colorado disaggregation technology for the refolding of insulin School of Mines. As part of the project, Siva will support a PhD glargine. BaroFold developed its first biosimilar, IFN-beta- student working in Dr. Boyes’ lab, and the grant will also support 1b (now in Phase III clinical trials with Nuron Biotech as a newly hired scientist at Siva. The long term vision of the project NU100), taking advantage of PreEMT to improve protein is to develop functional, environmentally-responsive polymers refolding and product safety. The technology is licensed from attached to the surface of gold nanorods. The polymers will be the University of Colorado. BaroFold will conduct refold able to present different functionalities, such as tumor targeting optimization experiments at high protein concentrations or a chemotherapeutic, which can be used in conjunction with the (>5 g/L) and perform process modeling. Based on success photothermal properties of the gold nanorods. with IFN-beta-1b, pressure refolding is expected to provide www.sivatherapeutics.com economic value in terms of reduced manufacturing cost-of- goods and will provide intellectual freedom-to-operate in comparison to traditional chemical-based approaches for this valuable biosimilar target. BaroFold plans on licensing its PreEMT refolding technology to an insulin glargine biosimilar manufacturer. www.barofold.com

Double Helix, LLC

The grantee is developing Widefield 3D Super resolution Microscopy Instrumentation for Biomedical Sciences, a 3D optical microscopy technology suitable for living cell studies. Double Helix is a start-up company that will commercialize the technology invented by Dr. Rafael Piestun at the University of Colorado and his collaborators. The technology allows for visualizing sub-cellular events without destroying cells, a capability that is essential to understanding the mechanisms and treatment of many diseases. Double Helix has recently received federal funding to support the development of a product module with 3D super-resolution capabilities that can be used with existing microscopes. The BDEG matching grant Pharmaceutical Research & Manufacturers of America funding supports development of a business plan to bring that Disease is our enemy. Working to save lives is our job. product to market.

BIOSCIENCE COLORADO 2013/2014 39 COMMERCIALIZATION INFRASTRUCTURE AWARDS 2012-2013

Biofrontiers Institute at Colorado Institute for Colorado State University– University of Colorado Drug, Device, and Diagnostic Colorado Center for Boulder Development (CID4) Drug Discovery

This grant supports the Formed in 2009 through the This grant supports the Colorado Center for Drug BioFrontiers Institute, BDEGP, CID4 accelerates life Discovery (C2D2) as a drug discovery resource that is formerly the Colorado science discoveries and bridges available to Colorado researchers. The C2D2 applies Initiative in Molecular the gap between research and industry-based medicinal chemistry knowledge, Biotechnology, in developing successful product developments. synthetic expertise, and drug discovery technologies a state-of-the art research The Institute serves universities, (e.g. chemical libraries, cheminformatics, and and education facility that bioscience companies, academic computer aided drug design) to drug discovery projects links the basic sciences, groups, and professional emerging from Colorado’s research institutions in engineering, clinical practice, associations by providing seed order to promote technical innovations that advance the and industry at the University funding, active management, understanding, diagnosis, and treatment of human and of Colorado’s Boulder campus investor connections and strategic animal disease. Working collaboratively with biology to support breakthrough consulting. CID4 received $4.75 researchers from public and private institutions, C2D2 developments in areas such million in total funding for grants generates novel compounds that enable investigators as engineering human tissues, from the state of Colorado and to conduct cutting edge research, develop intellectual RNA enzyme and aptamer the Fitzsimons Redevelopment property, acquire follow on funding, and form new based pharmaceuticals, Authority. As of 2012, CID4 has startup companies. Since its inception in 2010, biorefining, and genetics. five companies in its Project C2D2 has provided funding/resources to 22 programs Grant funds support Portfolio who have raised an (including 7 programs in FY2012) from across all of equipment, resources and additional $21 million in operating Colorado’s major research institutions. In FY2013 personnel costs to develop the funds leading to 195 direct and C2D2 has identified seven programs to provide with core facilities of the institute. indirect jobs. funding and/or medicinal chemistry support.

40 2013/2014 BIOSCIENCE COLORADO Medical Device and Related Companies DIRECTORY

Accu-Tube Corporation Englewood INDEX www.accutube.com Manufactures standard and custom size 41 Medical Device and Related Companies stainless steel hypodermic medical tubing.

54 Biotechnology, Pharmaceutical and Acertara Acoustic Laboratories, LLC Related Companies Longmont

www.acertaralabs.com 60 Biofuels and Related Companies Independent ISO/IEC accredited medical ultrasound acoustic measurement and testing 61 Research & Education Institutions laboratory.

64 Foundations Actall Security Products 65 Service Providers Denver www.actallsp.com Engineers, manufactures and markets wireless systems for hospital and pharmaceutical company facilities.

Actium Biosystems Boulder Medical Device and Related Companies Able Planet www.actiumbio.com Wheat Ridge Developing new technology to treat cancer 2C Technologies www.ableplanet.com through the use nanoparticles to weaken and Denver Developing an extensive line of audio and destroy cancer cells. www.2ctechcorp.com communications products that are usable by Development, validation, and people with all levels of hearing, and provide Advanced MicroLabs, LLC commercialization of “SeeQ” intraocular a means whereby users can listen at lower Fort Collins implant as a next generation in vivo system volumes without compromising full rich www.advancedmicrolabs.com for stimulating degenerated retinal cells and sound. Researches and develops chemical analytical restoring vision. instruments in ‘Lab-on-a-chip’ format. Accelr8 Technology Corporation Abilities Unlimited Denver Advanced Research Instruments Colorado Springs, Denver www.accelr8.com Corporation www.auiop.com Develops medical diagnostic technologies Golden Provides artificial limbs and custom for research and clinical applications. The www.aricorp.com orthopedic appliances. primary focus is rapid, integrated bacterial Produces preamplifiers for PMT’s and analysis system designed to identify, count, electron multipliers, high voltage power and provide complete antibiotic susceptibility supplies, counters and timers, precision rate data by bacterial species within a few hours of meters, and image analyzers for scanning sample injection without prior culturing. electron microscopes.

BIOSCIENCE COLORADO 2013/2014 41 Medical Device and Related Companies

Aerophase, Inc. AlloSource Aqueous Biomedical Longmont Centennial Colorado Springs www.aerophase.com www.allosource.com www.aqueousbio.com Research and Development of technologies that Develops, processes and distributes life- Develops biocompatible materials and reduce environmental impact, help economically enhancing bone and tissue allografts to the geometric designs that can be applied to disadvantaged people, and improve healthcare. medical community. stents, shunts, artificial organs and drug Including low cost, environmentaly friendly delivery devices. Their first product, the Meter Dose Inhaler and improved Aerosol AllPro Oculieve™ shunt, is designed to control Therapy for Lung Cancer Broomfield over-pressurization inside the eye caused by www.allprodental.com glaucoma. Aesthetic Technologies Produces a large selection of non-latex prophy Golden cups, prophy angles and other dental products. ArcScan, Inc. www.parisianpeel.com Morrison Manufactures and sells Parisian Peel® brand Alpha Mold West www.arcscan.com microdermabrasion systems and accessories Broomfield Early stage med device startup developing along with skin care products to medical, and www.alphamoldwest.com VHF Ultrasound for comprehensive spa professionals. Plastic injection mold-making facility for the ophthalmic imaging. medical industry. Aestis, Inc. Arcturus Star Products LLP Boulder Angioslide, Inc. Cortez www.altitudetraining.com/aux/about/aestis Wheat Ridge www.arcturusstar.com Develops a treatment for obesity through www.angioslide.com Pioneering Vibrational Energy Therapy for the controlled hypoxia technology. The two Privately held medical device company wellness and beauty professions. Vibrational principal components are the air separation that developed a unique Embolic Capture energies incorporate subtle low frequencies unit and proprietary control system. Angioplasty solution, PROTEUS™, which of light, sound, and electrical waves. Their provides a combination of PTA balloon and therapeutic specialty is in the area of Agilent Technologies embolic capture. lymphatic health. Englewood www.agilent.com Animal Care Systems, Inc. ASI Medical, Inc. Provides core electronic and bio-analytical Centennial Centennial measurement tools to advance life science www.animalcaresystems.com www.asimedical.net research. Provides innovative rodent caging systems for Developer of specialized mobile and the life-science industry. integrated dental carts, as well as unique AktiVax dental instruments for the modern dental Boulder/Aurora Animark, Inc. office. www.aktivax.com Aurora Developing novel reconstitution, safety www.animark.us Aspire Biotech, Inc. syringes for vaccines and biologics. Manufactures and sells ultrasound pregnancy Colorado Springs detectors and ovulation predictors for www.aspirebiotech.com Allergan, Inc. livestock breeding. Provides contract services for all phases of Denver product development from concept to launch, www.allergan.com Apdyne Medical Company and produces its own skin sealant and wound- Continually conduct research to develop Denver closure adhesives. products that enable medical specialists to www.apdyne.com help people preserve and protect their vision, Manufactures and distributes the Apdyne Auri-Stim Medical move freely, best express their inner beauty Phenol Applicator Kit used to anesthetize Denver and lead healthy and active lives. the tympanic membrane during in-office www.net1device.com myringotomy procedures. Offers an alternative therapy for migraine Allison Medical Inc headaches, hormonal migraine, chronic Littleton headaches, premenstrual syndrome (PMS), www.allisonmedical.com nicotine and narcotics addictions using the Develops products to assist specialists in the NET-1000 device. medical and veterinary industries, and have designed and provided essential syringes, needles and custom items for various industries.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

42 2013/2014 BIOSCIENCE COLORADO Medical Device and Related Companies

Avantes BioCare Systems, Inc. Boulder Diagnostics Broomfield Parker Boulder www.avantes.com www.biocaresystems.com www.boulderdiagnostics.com Produces, develops and sells spectrometers, Designs, develops and markets patent- Boulder Diagnostics is a specialty diagnostics light sources, fiber optic multiplexer, protected, FDA cleared, new health-care company dedicated to developing diagnostic fiber optic cables, software, fiber optics, devices (LumiWave™) that use deep-tissue reagents and test for infectious diseases and accessories to the medical device industry. light therapy to decrease pain, accelerate other protein targets that can benefit from healing and improve quality of life. a reliable, easy to use test for laboratory, Bal Seal Engineering, Inc. physician’s office or home use. We focus on Colorado Springs Biodesix, Inc. underserved markets where the current state www.balseal.com Aurora, Broomfield of the art is inadequate for effective diagnosis. Produces seals and canted-coil springs for www.biodesix.com sealing, holding, latching, and electrical Molecular diagnostics company advancing Boulder Innovation Group, Inc. contact in a variety of applications throughout the revolution in personalized medicine by Boulder the medical market. providing physicians timely and clinically www.boulderinnovators.com useful information. Develops and manufactures image-guided Baxter Healthcare Corporation surgical navigation digitizers and industrial Englewood Bio-Logistics Preclinical, Inc. 3D capture and modeling equipment. www.baxter.com Pierce Baxter International, through its subsidiaries, www.bio-logistics.com Broadwest Corporation develops, manufactures and markets products Offers engineering and regulatory support Denver that save and sustain the lives of people with and preclinical strategic development to the www.broadwest.com hemophilia, immune disorders, infectious medical device industry. Develops and manufactures ergonomic diseases, kidney disease, trauma, and other mammography viewing equipment. chronic and acute medical conditions. BiOptix Boulder C5 Medical Werks Beacon Biotechnology www.bioptixinc.com Grand Junction Aurora Offers a new, patented approach to label-free www.c5medicalwerks.com www.beaconbiotechnology.com analysis, called Surface Plasmon Enhanced Offers ceramic manufacturing, materials BrightSPOT Reader detection platform and interferometry (SPE). expertise, and custom engineering support luciferase-based diagnostic assays combine to prototype and commercialize designs and cutting-edge hardware and novel biology in a Biotricity Medical Inc. patents to orthopedic companies for hip, way that is both powerful and simple. Aurora spinal and dental implants. www.biotricitymedical.com Beckman Coulter Research and manufacturing company Canberra Industries Fort Collins specializing in developing long-term power Greenwood Village www.beckmancoulter.com requirements for implanted devices based on www.canberra.com Develops and produces instruments for the bioelectric generation. Manufactures and supplies analytical diagnostic industry. Specializes in the fields instruments, systems and services for of immunocytochemistry, flow cytometry, and BioVision Technologies, Inc. radiation detection and radiation monitoring. microbiology. Golden www.biovisiontech.com Car-May L.L.C. Bell Dental Products, LLC Develops and manufactures micro-visualization Berthoud Englewood solutions that enable endoluminal and minimally www.car-may.com www.belldental.com invasive medical procedures in both human and Unlike basic metering pumps, Car-May’s systems Designs, develops, and manufactures veterinary medicine. The imaging technologies provide pumping capability, fluid measurement, and precision dental equipment based on electric and customized micro-endoscope solutions are flow control all in one compact module. motor technology. integrated to reduce incision size and speed healing. Care Electronics, Inc. BiO2 Medical, Inc Boulder Golden BodySync, Inc. www.medicalshoponline.com www.bio2medical.com Aurora Offers a range of electronic monitoring and Medical device manufacturer founded www.bodysync.com alarm equipment for the home health and to design, develop, and subsequently Applies evidence-based genetic information long term care markets. manufacture a range of medical products in to develop personalized products that help response to clinical needs. individuals achieve their health goals. COLORADO BIOSCIENCE ASSOCIATION MEMBER

BIOSCIENCE COLORADO 2013/2014 43 Medical Device and Related Companies

Caroba Plastics, Inc. Certol International, LLC Colorado Laser Technologies, Inc. Englewood Commerce City Colorado Springs www.caroba.com www.certol.com www.coloradolasermarking.com Provides custom injection molds and Provide patients and healthcare professionals Provides YAG laser engraving technology, as specializes in the needs of the medical and with innovative products and responsible well as CO2 and YAG laser cutting services. high technology industries. solutions to the complicated infection control challenges of the 21st century. Colorado Precision Products, Inc. Carsan Engineering, Inc. Boulder Golden Clean Room Devices, LLC www.coloradoprecision.com www.carsaneng.com Westminster Provides diamond turned and polished optics/ Designs and manufactures products www.cleanroomdevices.com parts. Fabricator of X-ray telescope optical for several of the leading OEMs in the Manufactures products that are engineered components. Produces and offers air bearing medical, dental, industrial, semiconductor, specifically for “clean room” environments. LVDT contact linear measurement systems, entertainment, and video projection markets. .05 microinch resolution. Clifford Consulting & Research, Inc. Cascade TEK Colorado Springs COMEG U.S.A. Endoscopy, Inc. Longmont www.ccrlab.com Denver www.cascadetek.com Clifford Materials Reactivity Testing (CMRT) www.sopro-comeg.com Cascade TEK is an accredited medical device is a laboratory screening process used to A product range producing high quality video testing laboratory located in Longmont help identify existing sensitivity problems imagery that meets the needs of the surgeons CO and Oregon. Specializing in package to various chemical groups and families of in terms of products, budget and services, testing, accelerated aging, photostability, compounds in an individual patient. whatever their specialty. UV, temperature/humidity, vibration, shock testing services. Cochlear Americas Confi-Dental Products Company Centennial Louisville CEA Technologies, Inc. www.cochlearamericas.com www.confi-dental.com Colorado Springs Designs, manufactures and distributes Manufacture a wide range of dental and www.ceatechnologies.com hearing implants including the Nucleus healthcare products including composites, Provides product development and complete Freedom and Baha implants. cements, creams, lotions & ointments. product assembly and packaging services to the medical industry. ColdQuanta, Inc. CONMED Electrosurgery Boulder Centennial CeraPedics, Inc. www.coldquanta.com www.conmed.com Westminster Focuses on the development of BEC (Bose- Designs and manufactures RF electrosurgical www.cerapedics.com Einstein Condensate) generating devices generators and accessories of the highest Globally supplying the orthopedic and spinal and systems, allowing them to be accessible quality, safety and value for use in surgical communities with quality products, services to a wide range of research, educational, procedures performed in virtually every and educational opportunities to improve and industrial institutions. Our products are hospital, surgery center and physicians office. patient outcomes intended for use in scientific and industrial applications requiring high performance and CoorsTek CereScan reliability. Golden Denver www.coorstek.com www.cerescanimaging.com Colibri Heart Valve Custom engineering, materials expertise, Specialize in state of the art functional Broomfield operational excellence, and rapid execution. brain imaging utilizing a proprietary www.colibrihv.com process including the latest generation high Researches and develops novel heart valve resolution gamma camera, the industry’s technologies. leading brain image reconstruction software, specially trained board-certified physicians and research-based knowledge to provide unparalleled diagnostic medical reports.

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44 2013/2014 BIOSCIENCE COLORADO Medical Device and Related Companies

Corgenix Medical Corporation DataWave Technologies Corporation Die Cut Technologies Broomfield Berthoud Northglenn www.corgenix.com www.dwavetech.com www.diecuttech.com The Colorado facility is engaged in research, Manufactures a wireless and battery-free Offers precision material conversion, skilled development, manufacture, and marketing of device for acquiring and transmitting assembly and manufacturing efficiencies, in vitro diagnostic products for use in disease data from electrodes and other biosensors including cleanroom facilities. detection and prevention. to a receiver placed meters away for electrophysiology, neurophysiology and Directed Energy Solutions Covidien physiology related research on both humans Colorado Springs Boulder and large animals. www.denergysolutions.com www.covidien.com Develops advanced laser and optical device Offers an extensive product line, including dBMEDx solutions for medical applications. pulse oximetry and airway and temperature Littleton management devices, ventilators, vessel www.dbmedx.com DNTLworks Equipment Corporation sealing, and electrosurgery equipment. Developing next-generation, automated, Centennial wireless 3D ultrasound devices based upon www.dntlworks.com Crosstrees Medical, Inc. our patent-pending full-view architecture. Manufactures portable, mobile and self- Boulder contained dental systems. www.crosstreesmedical.com DCS Surgical Privately-held company developing advanced Boulder Double Helix devices and instruments for the treatment of www.dfjmercury.com Boulder vertebral body compression fractures (VCF) Early stage company formed to evaluate Emerging startup that commercializes in the spine. potential new surgical procedures for the computational optical-digital imaging treatment of sinusitis. technologies used in range estimation, Chart Denver super-resolution, and 3D imaging biomedical Denver Denver Instrument Company imaging. www.chartindustries.com Arvada Manufacturing services to companies who www.denverinstrumentusa.com dpiX, INC. want to out-source some or all of their Designs and manufacturers analytical Colorado Springs manufacturing processes, and to companies balances, electrochemistry instruments, www.dpix.com that have capacity issues with their current moisture analyzers, and titration controllers. Produces high-resolution amorphous silicon manufacturing resources. (a-Si) sensor arrays for medical X-ray Denver Optic Company imaging. C. R. Bard, Inc./Medivance Englewood Louisville www.eyeprosthetics.com E.I. Medical Imaging www.crbard.com Specializes in the fitting and fabrication of Loveland Leading multinational developer, two types of ocular prosthesis. www.eimedical.com manufacturer and marketer of innovative, life- Manufacturer of highly portable and enhancing medical technologies in the fields Desert Glass Works ruggedized ultrasound devices for the of vascular, urology, oncology and surgical Colorado Springs veterinary industry. specialty products. www.dgw.com Manufactures quartzware for the medical and Eido CytoLogic Inc. research industries. Broomfield Boulder Anatomic localization medical device www.cytologic.com Diazamed developer in patent pending stage. Commercialization of an immunotherapy Fort Collins device for treatment of cancer. www.diazamed.com Eldon James Corporation Development of advanced materials and Loveland Darkhorse Technologies utilize leading technologies to create more www.eldonjames.com Boulder biocompatible surfaces. Designs and manufactures a diverse line of [email protected] plastic and stainless steel hose fittings with a Commercializes a patented technology for single-barb design. affordable, hand-carried, battery operated instruments for on-site genetic detection using Polymerase Chain Reaction (PCR).

COLORADO BIOSCIENCE ASSOCIATION MEMBER

BIOSCIENCE COLORADO 2013/2014 45 Medical Device and Related Companies

Electronic Materials, Inc. (EMI) Evergreen Research, Inc. FlashBack Technologies Breckenridge Golden Longmont www.emiuv.com www.evergreenresearch.com www.flashbacktechnologies.com Offers a complete line of EMCAST UV Offers a complete range of development Fast, non-invasive detection of acute blood adhesives, epoxies, sealants, encapsulants and services from product definition and loss volume and prediction of cardiovascular coatings, EMI also offers room temperature, feasibility studies through detailed design to collapse in emergency situations. thermal and Visible light cure adhesive systems. pilot-run and low-volume production to the medical device industry. Fluonic Ellab, Inc. Boulder Centennial Eveia Medical www.fluonic.com www.ellab.com Boulder Develops infusion therapy systems with Manufactures thermal validation solutions for www.eveiamedical.com disposable sensors for OEM and proprietary food and pharmaceutical industries. Development stage company focused on pumping systems. creating a bioanalytical system designed Empirical Testing Corporation to conduct immunassay tests. Ky attributes Futura Surgical Inc. Colorado Springs include; lowfemtomolar sensitivities, short assay Wheat Ridge www.empiricaltesting.com development cycles and results in 10-20 minutes. www.futurasurgical.com Provides medical device testing services The product consists of the instruments, software Development, manufacture and sales of that add value throughout the product and reagents required for analyte measurement. orthopedic products development cycle, with a focus on spinal implant device testing. Extreme Diagnostics GE Analytical Instruments Boulder Boulder Encision, Inc. www.extremediagnostics.com www.geinstruments.com Boulder Develops noninvasive measurement systems, Manufactures instruments used to measure www.encision.com including optical systems such as custom total organic carbon (TOC) in water for Designs and manufactures innovative surgical holographic and interferometric instruments. pharmaceutical applications and medical devices. Developed AEM® Laparoscopic Specializes in structural health monitoring, research. Instruments to improve electrosurgery nondestructive testing, and materials and reduce the chance for patient injury in processing. Genesee BioMedical, Inc. minimally invasive surgery. Denver Falcon Rehabilitation Products www.geneseebiomedical.com EndoShape, Inc. Denver Manufactures cardiac surgery instruments and Boulder/Aurora www.falconrehab.net devices. www.endoshape.com Designs and builds high quality, innovative Manufactures surgical and medical quadriplegic seating systems and accessories Gnathodontics, Ltd. instruments focusing on shape memory (Falcon Rehabilitation Products, LaBac Lakewood polymer devices for endolumenal application. Seating Systems, Gel Ovations). www.gnatho.com Specializes in functional dentistry, advanced Enplas Corporation Firefly Medical, Inc. implant work, precision partial dentures, Colorado Springs Fort Collins combination cases and metal-free fixed www.enplas.com www.fireflymedicalinc.com restorations. Enplas is striving to gaze into the future Designs and develops innovative durable through “OPTPLANICS”: a new concept medical equipment for clinical healthcare Grant Dental Technology Corporation that fuses the latest optical and electronics markets. Colorado Springs technologies on the basis of engineering www.grantdentaltech.com plastics, the highly functional materials that Fischer Medical Technologies, Inc. Dental implants and surgical/restorative tools. Enplas has been pursuing since its inception. Broomfield www.fischermti.com Hach Company es2 TECHNOLOGIES, INC. Designs, manufactures, and markets imaging Loveland Englewood systems for the screening and diagnosis of www.hach.com www.es2technologies.com breast cancer. Manufactures and distributes analytical Product design group that specializes in instruments and reagents used to test the bringing concepts to life through an inter- quality of water and other aqueous solutions. disciplinary system engineering, product safety and manufacturing engineering team.

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46 2013/2014 BIOSCIENCE COLORADO Medical Device and Related Companies

HEI Advanced Medical Operations Infinity Photo-Optical Company Jortek Surgical, Inc. Boulder Boulder Boulder www.heii.com www.infinity-usa.com www.jortek.com Develops and manufactures high performance Manufactures long-distance and continuously- Develops innovative orthopedic devices with components, medical software, medical focusable microscope technology, macro a focus on joint and tissue preservation and devices, and non-medical products. Produces systems, internal-focusing devices and other augmentation. microcircuits and subsystems for hearing and lenses. medical applications. Kent Systems Injectech, LLC Loveland Loveland www.kentsystems.com Hirsh Precision Products, Inc. www.injectech.net KENT Systems designs, manufactures, and Boulder Provides molding, assembly and design distributes Plastic Quick Couplings, Tube www.hppi.com of medical components and fittings for Fittings, and Media Bags. Manufactures precision-machined and OEM device manufacturers. Class 100,000 assembled components for the medical cleanroom molding and assembly available. Kestrel Labs, Inc. industry. Boulder Instec, Inc. www.kestrellabs.com Hyperion Labs, LLC Boulder Kestrel Labs combines internal research and Fort Collins www.instec.com development projects with consulting and www.hyperion-labs.com Manufactures precision temperature contract development of innovative, patient Plasma-based modifications including: controllers and microscope hot stage monitoring concepts and other medical self organized patterning or texturization, systems for temperature cycling, food technologies. physical thin film deposition, plasma sciences, materials characterization, enhanced chemical vapor deposition, and ion forensics, polymers and liquid crystals and Kurz Medical implantation. microbiology. Aurora www.kurzmed.com Illumasonix LLC Intertek Manufactures and sells ENT devices Aurora Boulder worldwide. We are in particular focused on www.alliedminds.com/subsidiaries/ www.intertek.com passive middle ear implants/prosthesis for ilumasoni^a In partnership with Allied Offers testing, inspection and certification ossiculoplasty in titanium and nitinol. Minds, we will develop and commercialize a of products, commodities and systems for new non-invasive vascular disease detection medical devices. Performs FDA 510(k) Lanx, LLC procedure which will provide near real-time reviews, electrical safety certification Broomfield assessment of detailed blood flow patterns including CE Marking, testing to the www.lanx.com within the cardiovascular system. MDD and IVDD, risk analysis, EMC and Specializes in systems and implants for performance testing. all segments of spinal surgery. Integrating Imagistx, Inc. leading technology, intellectual property and Highlands Ranch IPAX, Inc. state-of-the-art engineering, each product is www.ImagistxProstate.com Englewood designed to simplify surgery and improve Ultrasound system that is potentially able www.ipaxinc.com the quality of care for patients worldwide by detect and target for biopsy and focal therapy Assembles and packs medical products, providing surgeons with innovative spinal prostate cancer. focusing on bringing new medical products to products. the marketplace. Specialty is small to medium InDevR, INC. production runs, also has the capacity and the Leap Frogg, LLC Boulder manpower to take on the larger jobs. Grand Junction www.indevr.com 970-260-7494 Develops and manufactures biomedical Jorgensen Laboratories, Inc. Dynamic compression system which reduces instruments including molecular diagnostic Loveland nursing time and is more comfortable. assays, virus measurement systems and www.jorvet.com detection technologies for micro-arrays. Designs and manufactures instruments which are used in the animal health field including specialty instruments, surgical suture, and veterinary equipment.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

BIOSCIENCE COLORADO 2013/2014 47 Medical Device and Related Companies

Leeds Precision Instruments, Inc. mBIO DIAGNOSTICS Micro Imaging Solutions, LLC (MIS) Denver Boulder Englewood www.leedsmicro.com www.mbiodx.com www.micro-imaging.us Offers microscopes and custom-engineered Develops a low-cost, high sensitivity, multi- Developed an innovative-patented technology products ranging from small modifications on pathogen detection system for diagnostics. that can be utilized in the manufacture a microscope stand that accommodate specific of micro-digital CMOS cameras. applications, to large specialized systems, such as Medical Modeling, Inc. an optical comparison bridge for forensic science. Golden Microlife Medical Home Solutions, Inc. www.medicalmodeling.com Golden Lenox MacLaren Surgical Instruments Produces highly accurate 3-D physical models www.mimhs.com Louisville of human bone structure from imaging such Proprietary hand-held medical devices and www.lenoxmaclaren.com as CT or MRI. systemic solutions offer healthcare providers Manufactures precision orthopedic and evidence-based and practice-tested methods neurological surgical instruments. Medtronic Navigation, Inc. for accurate assessment, diagnosis, and Louisville treatment of cardiovascular and metabolic Light Labs www.medtronicnavigation.com diseases. Aurora At the forefront of surgical navigation www.lightlabsusa.com solutions, guiding the industry to a higher Distributes, PCR tubes, TPP tissue culture, standard of care for several clinical Mikron Corporation Denver pipette tips, microcentrifuge tubes, barrier specialties, including cranial neurosurgery, Aurora tips, latex gloves, PCR supplies, and much functional neurosurgery, spinal, ENT, www.mikron.com more. joint replacement and orthopaedic trauma Supplies transfer machining systems for surgeries. complex parts, cutting tools with high Logisens Corporation performance standards, self medication and Fort Collins diagnostic devices. www.logisens.com Meinhard Glass Products Develops biosensor and software technology, Golden Mind Studios enabling a significant breakthrough in real- www.meinhard.com Colorado Springs time measurement and reduction of stress. Produce finer, more narrowly sized-dispersed www.mind-studios.com aerosols while maintaining the high quality, A full service product design and research Magnelab, Inc. low cost and simplicity of design and studio housed within the University of Longmont operation that characterize the MEINHARD® Colorado at Colorado Springs. Offers www.magnelab.com nebulizer. concept generation, advanced prototyping, Manufactures custom magnetic components engineering and consumer research, human (transformers/inductors) for the medical field. Mesa Laboratories, Inc. factors design and manufacturing solutions. Lakewood Mayer Medical Technologies, Inc. www.mesalabs.com Mitomics (USA) Inc. Grand Junction Provides dialysis meters and related supplies Aurora www.mayermedical.com to dialysis clinics world wide. www.mitomicsinc.com Mayer Medical Technologies, Inc. improves Pioneering the development of molecular tests health and saves lives by innovating new Metamatrix, LLC based on the mitochondrial genome in order products, providing seed capital to medical Boulder to improve clinical insight and therapeutic start-ups, and assisting medical professionals www.zorbent.com decisions that affect patients worldwide. in developing their product ideas. Manufacturers of ZORBENT which absorbent is designed to leave no residue, Montview Biomedical Design Inc (MBD Inc.) reducing the risk associated with slippery montviewbiomed.com surfaces and is completely safe to use and Aurora represents no health hazard Designs, develops and creates engineering solutions for the biomedical industry.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

48 2013/2014 BIOSCIENCE COLORADO Medical Device and Related Companies

MuscleSound, LLC Otologics, LLC Peddle Master, Inc. Denver Boulder Johnstown musclesound.com www.otologics.com www.peddlemaster.com Developed a process to measure muscle Develops and commercializes surgically Designs and manufactures handicapped glycogen content real time using non-invasive implantable alternatives to conventional “in driving aids. The Peddel Master is totally ultrasound technology. the ear” hearing aids. portable and can be installed and removed in a matter of seconds. nSPIRE HEALTH, INC. Oval Window Audio Longmont Nederland Pernicka Corporation www.nspirehealth.com www.ovalwindowaudio.com Fort Collins Develops, manufactures and markets Produces induction loop assistive listening www.pernicka.com respiratory care products and services focused systems and visual and vibrotactile Offers analytical testing that meets or exceeds on cardiopulmonary diagnostics, respiratory technologies that help deaf and hard of the requirements of MIL-STD 750/883 core lab services, and disease management hearing individuals. method 1018 and 45662A for companies solutions. in the semiconductor, aerospace, basic & Paré Surgical, Inc. applied research, surface analysis, thin film NEBA Health LLC Centennial deposition, laser technology, and medical Boulder www.paresurgical.com products industries. www.nebahealth.com Develops surgical instruments such as the Develops neuropsychiatric medical devices, Quik-Stitch endoscopic suturing system. PharmaJet, Inc. such as Neba™ an experimental, small format Golden EEG-based device being studied under an Parke1r Medical www.pharmajet.com Investigational Device Exemption from the Highlands Ranch Develops a needle-free technology that has a Food and Drug Administration. www.parkermedical.com low cost, single use, disposable polypropylene Provides airway management products that vial or cartridge, suitable for the delivery Neuro Assessment Systems make intubation safer for the patient and of common vaccines and standard dose Denver easier for the medical professional. injectable liquid medicines. www.neuroassessments.com Provides an objective brain-based measure Particle Measuring Systems Physical Activity Innovations of neurocognitive symptoms associated with Boulder Fort Collins a wide range of brain health issues including www.pmeasuring.com Developing unique, footwear-based systems concussion and Alzheimer’s disease. Designs, manufactures, and services that motivate users to increase their daily precision microcontamination monitoring physical activity. Olympus Soft Imaging Solutions instrumentation and software used for Corporation (OSIS) detecting particles in aerosols, liquids, PolyNEW, Inc. Lakewood slurries, gas streams and vacuum processing Golden www.soft-imaging.de environments as well as surface molecular www.polynewinc.com Produces, markets, and sells image acquisition contamination monitoring. Develops Polymer ice and methods of making and processing software and hardware for all and using them. areas of electron microscopy. PCC/Advanced Forming Technology Longmont Porta-Lung, Inc. Optibrand Ltd., LLC www.pcc-aft.com Lakewood Fort Collins Offers thixoforming and metal injection www.portalung.com www.optibrand.com molding for the medical device industry. Provides non-invasive ventilator support for Developed optical imaging system for long-term patients who need more portability veterinary diagnostics. Peak Robotics, Inc. than the iron lung allows, while maintaining Colorado Springs the same level of ventilating efficiency. OptiEnz Sensors www.peakrobotics.com Centennial Manufactures robots, special equipment, and www.optienzsensors.com turnkey automated systems for a variety of OptiEnz has revolutionized measurement industries including: biotech, electronics, capabilities for organic chemical medical, semiconductor, etc. concentration; now providing continuous, real-time, in-place sensor solutions.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

BIOSCIENCE COLORADO 2013/2014 49 Medical Device and Related Companies

Precision Biopsy Protomed, Inc. RJD Machining Aurora Westminster Parker In partnership with Allied Minds, we are www.protomed.net www.rjdmachining.com working to develop and commercialize Creates accurate anatomical models from CT Specializes in precision production runs technology for the accurate diagnosis scans by using the latest imaging software and and some prototype work for OEM’s in the of prostate cancer which uses advanced laser driven technology. medical industry. spectroscopy imageing techniques in combination with tissue biopsy. Prototype Casting, Inc. Rocky Mountain Instrument Company Denver (RMI) Precision Diagnostic Instruments www.protcast.com Lafayette Westminster Manufactures non-ferrous prototype parts www.rmico.com www.pdimeters.com for the medical industry, specializes in RPM Designs and manufactures optics and coatings Designs and manufactures professional (Rubber Plaster Mold) casting, sand casting (ultraviolet through far infrared) for the quality, affordable test equipment. and rapid investment casting. medical industry.

Precision Glassblowing PTA Corporation Rocky Mountain Orthodontics, Inc. (RMO) Centennial Longmont Denver www.precisionglassblowing.com www.ptacorp.com www.rmortho.com Provides custom and OEM scientific glass for Manufactures aluminum and steel molds Serves all areas of orthodontics including custom synthesis, pharmaceutical, environmental, for projects with lifetime runs of 5,000 to pediatric orthodontic prevention, petrochemical, research, commercial, government 250,000 pieces for medical applications. interceptive pediatric orthodontics, mixed and medical laboratories. dentition orthodontics, adult orthodontics, Quest Product Development Corporation reconstructive dentistry orthodontics, TMJ Preferred Medical Products, Inc. Wheat Ridge orthodontics, surgical orthodontics and Englewood www.quest-corp.com breathing/sleep problem related orthodontics. www.preferredmedicalproducts.com Helps bring to market medical products Manufactures stainless steel medical and analytical systems for small start-ups Samson Design Associates, Inc. components for hypodermic needles and to research universities and international Boulder lancet type products. corporations. grants from NIH, DOD, NASA www.samsondesign.com and NIST. Provides full service product development Prescott’s, Inc. ranging from concept to production Monument Radiological Imaging Technology, Inc specifications, with many products for the www.surgicalmicroscopes.com Colorado Springs medical field. Provides reconditioned operating microscopes and www.radimage.com allied accessories that function as intended by the Provides clinical and research physicists Sandhill Scientific original equipment manufacturer. with a high precision automated QA tool for Highlands Ranch advanced radiation therapies. www.sandhillsci.com Probetronix, LLC Designs, manufactures and distributes Colorado Springs Rand-Scot, Inc. diagnostic products focused on Manufactures oscilloscope probes. Fort Collins gastroenterology. www.randscot.com Products Group International, Inc. Designs and manufactures products for Science Care Lyons persons with disabilities including BBD Aurora www.productsgroup.com Cushions and Mattress Overlays, EasyPivot www.sciencecare.com Researches, develops and engineers Patient Lifts, and Saratoga Exercise Products. Provide human tissue for medical research ultrasound medical and veterinary equipment. and education. We serve as a link between individual donors and medical researchers and Propel Labs, Inc. Rapid Prototying Corporation educators. Fort Collins Longmont www.propel-labs.com www.rapidpro.com Scientech, Inc. Experienced and knowledgeable instrument Offers engineering and design and other Boulder development team designing the next manufacturing services for the medical device www.scientech-inc.com generation of bio-instrumentation tools. industry. Manufactures analytical instruments: semi- Focused on research tools, such as single cell micro balances, analytical balances, semi- analyzers and cell sorters. analytical balances, and toploading balances for the medical industry. COLORADO BIOSCIENCE ASSOCIATION MEMBER

50 2013/2014 BIOSCIENCE COLORADO Medical Device and Related Companies

Scott Orthotic Labs, Inc. Snoasis Medical Spectranetics Corporation Fort Collins Denver Colorado Springs www.scottorthotic.com www.snoasismedical.com www.spectranetics.com Manufactures Orthotic and Prosthetic Focused on the development and Develops, manufactures, markets and Components, Pre-fabricated Orthotics, and commercialization of regenerative tissue and distributes single-use medical devices used Custom O&P Devices. medical device products for use in dental in minimally invasive procedures within the surgery. cardiovascular system. Securisyn Medical Highlands Ranch SomaLogic, Inc. ST Cardio Technologies, LLC www.securisyn.com Boulder Broomfield Dedicated to a continuous process of www.somalogic.com www.stcardio.com increasing the safety and effectiveness of our Uses aptamer array technology and Designs, develops, and manufactures unique life-saving product, which is utilized bioinformatics capabilities to discover electronic medical devices for use in by skilled medical practitioners to deliver the disease-specific biomarkers and protein electrophysiology cardiac cath labs. highest quality emergency and intensive care signatures. Develops medical diagnostics to their patients. based on these signatures. St. Renatus, LLC Fort Collins Sealcon Sontec Instruments, Inc www.st-renatus.com Centennial Centennial First needle-free, dental anesthetic suitable for www.sealconusa.com www.sontecinstruments.com use in procedures involving most of the upper Manufactures cable management components, Provides a broad line of instruments as well teeth. Uses an accurate and sophisticated including liquid tight strain relief fittings, as custom instrument manufacturing and in- method to anesthetize the upper teeth without flexible conduit, M23 circular connectors and house repair service. the risk and pain of a needle. related products for the health care industry. Sophono, Inc. StnDrd Infusion Shape Ophthalmics LLC Boulder Parker Aurora www.sophono.com www.stndrdinfusion.com Develops state of the art devices and novel Developed the world’s first non-percutaneous, Early-stage medical device company in the treatments for ophthalmic conditions through implantable bone anchored hearing device. drug infusion market with a standardized the application of advanced smart materials. pump capable of performing the product Sorin Group requirements currently met by syringe, Sharklet Technologies, Inc. Arvada cassette, and ambulatory pump configurations. Aurora www.sorin.com www.sharklet.com Develops and produces cardiovascular and StrionAir, Inc. Engineers surface technologies (Sharklet™) autologous transfusion therapy products. Louisville that controls the growth of dangerous bacteria. www.strionair.com Sound Surgical Technologies, LLC Manufactures and markets a product that uses Shippert Medical Technologies Louisville disposable media and that can be installed in Corporation www.vaser.com any air handler or HVAC system. Centennial Offers ultrasonic technologies and related www.shippertmedical.com techniques for aesthetic surgery. Stroke Recovery Systems, Inc. Manufactures and distributes medical Denver disposable products and instruments. Serves Sparton www.strokeaid.com the ear, nose and throat, plastic surgery, Frederick Develops the AutoMove AM800 that teaches cosmetic surgery, emergency/trauma care, www.sparton.com healthy parts of the brain after a stroke to take family practice, pediatric, ophthalmology and Leading contract manufacturer of low to over lost functionality. dermatology fields. medium volume, complex products for the medical device, biotech and industrial Summit Doppler Systems Sienco, Inc. instrumentation markets. Golden Arvada www.summitdoppler.com www.sienco.com Spectrum Laser & Technologies, Inc. Manufactures ultrasound Doppler systems Manufactures and distributes Class II medical Colorado Springs used to detect fetal heartbeat and to monitor devices, disposable supplies, reagents and www.spectrumlaser.com peripheral arterial and venous blood flow. accessories for in-vitro diagnostic use. Also, Provides contract design and manufacturing provides tools for hemostasis monitoring and services for the medical industry. viscoelastic evaluations. COLORADO BIOSCIENCE ASSOCIATION MEMBER

BIOSCIENCE COLORADO 2013/2014 51 Medical Device and Related Companies

Sundance Diagnostics, Inc. TRS, Inc. TeraBAT Boulder Boulder Longmont www.sundancedx.com www.oandp.com/products/trs www.terabat.com Working to develop the world’s first genetic Develops, manufactures, and markets body- Developing a disruptive detection platform safety tests to predict a patient’s risk of powered prosthetic devices. Designs and based on terawaves technologies that will antidepressant-induced suicidal thinking or builds technology for persons missing hands. revolutionize disease diagnosis and patient behavior. care. Tapeless Wound Care Products, LLC Sunrise Medical Inc Englewood Terumo BCT Longmont www.tapelesswoundcare.com Lakewood www.sunrisemedical.com Manufactures and distributes a system of www.terumobct.com Provides home healthcare products including patented secondary wound dressing retention A global leader in blood component and wheelchairs, respiratory, daily living aids, and devices, offering an alternative to traditional cellular technologies, is the only company speech augmentation devices. secondary wound dressings, for both human with the unique combination of apheresis and animals. collections, manual and automated whole Surefire Medical Inc. blood processing, and pathogen reduction Boulder Tartan Orthopedics, Ltd coupled with leading technologies in www.surefiremedical.com Northglenn therapeutic apheresis and cell processing. The company is developing a novel infusion www.tartanortho.com system for the interventional radiology Manufactures sacro lumbar belts, dorsal The Harloff Company market. lumbar belts (corsets and moldable inserts), Colorado Springs Ottenberg style elbow splint, pelvic www.harloff.com SurgiReal Products traction belts, arm slings, cervical collars, Manufactures and sells a line of crash carts, Fort Collins acromioclavicular splints, and ankle supports. medication carts and other specialty carts for www.surgireal.com hospitals, nursing homes, clinics and surgery Creates and introduces innovative products TDA Research, Inc. centers. and methods for surgical training. Wheat Ridge, Golden www.tda.com The Synaptic Corporation Supreme Cable Technologies, Inc. Provides automated catalyst testing equipment Aurora Thornton to large chemical companies and national www.synapticusa.com www.supremecable.com laboratories. Develops Synaptic®, a patented pain control Manufactures quality custom cable assemblies technology that works without drugs. and wire harnesses. Tech-X Corporation Marketed in accordance with FDA regulations Boulder for the treatment of acute and chronic pain. Swan Valley Medical, Inc. www.txcorp.com Aurora Specializes in scientific and engineering TheraTogs, Inc. www.swanvalleymedical.com software, including visualization and Telluride Developed a line of urology instruments that algorithm development. www.theratogs.com allow for safer, faster, and more economical Produces an orthotic undergarment and treatment of common urological disorders. Tensegrity Prosthetics, Inc. strapping system that gives clients with Boulder sensorimotor impairment a new modality for Synergy Health Americas www.tensegrityprosthetics.com improving postural alignment and stability. Denver Develops a prosthetic foot that mimics the www.synergyhealthplc.com functional biomechanics of the human foot in Tissue Genetics, Inc. Offers electron beam sterilization for medical walking. Denver and pharmaceutical devices. www.tissuegenetics.com Telsano Health Molecular diagnostics company with unique Synthes, Inc. Aurora technology for improving the care of patients Monument www.telsano.com with genetic diseases using biomarkers to www.synthes.com Telsano manufactures both the preventive identify patients with hereditary diseases and Develops, produces and markets instruments, health monitoring devices that gathers and to determine the course of care. implants and biomaterials for the surgical analyzes our personalized data but also fixation, correction and regeneration of the provides the innovation to securely display human skeleton and its soft tissues. your data and trend charts anywhere anytime.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

52 2013/2014 BIOSCIENCE COLORADO Medical Device and Related Companies

TMJ Implants, Inc. Ultrathera Technologies, Inc. Wi LLC – Medical Device Product Golden Colorado Springs Development www.tmj.com www.ultrathera.com Englewood Designs and manufactures alloplastic implants Life sciences company dedicated to improving www.wiinc.net for the treatment of temporomandibular joint human performance by applying advanced Designs and engineers medical devices. disorders and injuries. technologies to physiological and neurological Including innovative services such as laser needs. Maker of AeroStim™ and PointScribe™. welding, assay design, and air bubble Toltec International, Inc. management. Lakewood Unisyn Medical Technologies www.toltec.biz Golden Ximedix, Inc. Toltec provides medical device engineering www.unisynmedical.com Colorado Springs services compliant with US FDA and Leading provider of sustainable solutions to www.ximedix.com international regulatory standards. We the diagnostic imaging industry. Manufactures and sells single patient assist medical device companies with use medical products for the anesthesia, the development and maintainence of Value Plastics, Inc. respiratory care, critical care and emergency medical devices in full compliance with the Fort Collins medicine applications. regulations and standards. www.valueplastics.com Designs and manufactures plastic tubing Xntera Touch of Life Technologies, Inc. fittings and connectors. Aurora (ToLTech) Medical Devices will produce initially Aurora ValveXchange, Inc. premium medical syringes for dental www.toltech.net Greenwood Village market with the strategic product benefits of Develops procedural simulators in the areas of www.valvexchange.com automatic safety, ease of use, and comfort orthopaedics, gastroenterology, rheumatology, Develops a bioprosthetic heart valve with for the patient. Later on products will be radiology, ophthalmology, and general a percutaneously-exchangeable leaflet set developed to meet the demands in other surgical procedures. that provides lifetime service without anti- medical fields such as psychiatric, nuclear and coagulation therapy. diabetes. Transtracheal Systems, Inc. Englewood Vista LifeSciences Yamato Corporation www.tto2.com Parker Colorado Springs Develops and manufactures innovative www.vistalifesciences.com www.yamatocorp.com respiratory therapy products that advance Innovative Healthcare Technology Solutions Manufactures and sells weighing equipment medical therapy for persons requiring for Global Healthcare Challenges and systems for medical facilities. continuous supplemental oxygen, including the SCOOP transtracheal oxygen therapy WalkMed Infusion, LLC Zetek, Inc. system. Englewood Aurora www.walkmed.net www.zetek.net Trelleborg Sealing Solutions Mountain Offers solutions for ambulatory infusion Manufactures the OvaCue family of ovulation Broomfield therapy and pain management. prediction products. www.trelleborg.com Supplies high-quality products and solutions WAVi Company Zynex Medical, Inc. for industrial sealing and bearing systems. Boulder Lone Tree Activities are focused in many business The platform is based on the www.zynexmed.com areas including the food and pharmaceutical Electroencephalograph (EEG) that integrates Offers electrotherapy products, utilizing industries, as well as medical engineering. with physician diagnostic tools and a research various methods of non-invasive muscle library. Helps with interpretation and stimulation and electromyography UltraLinq Healthcare Solutions, Inc. treatment of brain ailments and performance technology, Interferential Current (IFC) and New York, NY including TBI, PTSD, Alzheimer’s Age Transcutaneous Electrical Nerve Stimulation www.UltraLinq.com Management and depression. (TENS). Cloud-based medical image management solution providing users with the ability to WestMed, Inc. view, review, collaborate,transport and archive Greenwood Village images and data. www.westmedinc.com Designs, manufacturers and markets medical devices to anesthesia and respiratory professionals.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

BIOSCIENCE COLORADO 2013/2014 53 BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES

American Allied Biochemical, Inc. Aquatic BioSystems Biotechnology, Pharma and Related Companies Aurora Fort Collins www.aablabs.com www.aquaticbiosystems.com Accera, Inc. Specializes in the purification and distribution of Full-service organism culturing facility specializing Broomfield restriction endonucleases enzymes. in the production and distribution of freshwater www.accerapharma.com and marine organisms for aquatic toxicology, Commercial-stage healthcare company focused Amgen, Inc. biomonitoring and other research activities. on the discovery and development of pioneering Boulder/Longmont therapeutics to treat serious diseases. Accera www.amgen.com ARCA biopharma, Inc. has developed Axona, the first proprietary Discovers, develops, manufactures and markets Broomfield, Aurora commercialized Alzheimer’s disease therapy that human therapeutics based on advances in cellular www.arcabiopharma.com address the recognized physiological hallmark and molecular biology. Amgen’s operations in Specializes in developing and commercializing and metabolic defect of hypometabolism, the brain’s Colorado are dedicated to the mission of assuring genetically-targeted therapies for heart failure and inability to optimally metabolize glucose.x patient supply and creating a world-class capability other cardiovascular diseases. for rapid commercialization, launch and transfer ADA Technologies, Inc. of bulk biopharmaceutical products. In addition Ariel Pharmaceuticals Littleton to licensed manufacturing of EPOGEN, NPlate, Broomfield www.adatech.com XGEVA, Prolia and clinical therapeutics, Amgen www.arielpharma.com Development and commercialization of innovative Colorado pursues strategic contract manufacturing Clinical-stage specialty pharmaceutical company technologies. opportunities. focused on acute neurology. Lead product, AP- 1531, is an EP4 receptor antagonist in Phase II Advanced Regenerative Therapies (ART) AmideBio, LLC for acute migraine. Tamiasyn is a proprietary IV Fort Collins Boulder product in Phase I for hemorrhagic shock. Both www.art4dvm.com www.amidebio.com products target major unmet medical needs where Provides a stem cell isolation and expansion service Focused on providing peptide and protein research there is little competition. for veterinary medicine. reagents and clinical products for a diverse array of research and commercial targets using proprietary Array BioPharma Agilent Nucleic Acid Solutions Biopure-Process™ technology. Boulder, Longmont Boulder www.arraybiopharma.com www.agilent.com Ampio Pharmaceuticals, Inc. Discovers, develops and commercializes targeted Agilent Nucleic Acid Solutions develops and Denver small molecule drugs to treat debilitating and life- manufactures therapeutic oligonucleotide in a multi- ampiopharma.com threatening diseases such as cancer. product, 33,500 square foot facility. Develops innovative proprietary drugs for inflammation, eye disease, kidney disease, CNS Atlas Biologicals, Inc. Agripro COKER disease, metabolic disease and male sexual Fort Collins Berthoud dysfunction. www.atlasbio.com www.agriprowheat.com Manufacture, market and distribute animal sera and Develops and delivers superior wheat seed genetics AntriaBio cell culture reagents in North America. Denver antriabio.com Aurogen AKTIV-DRY Lead diabetes product candidate, AB101, is a once- Fort Collins Boulder a-week injectable basal insulin that is currently in www.aurogen.com www.aktiv-dry.com preclinical development. AB101 is administered Produces a pharmaceutical treatment for diabetic Provides dry powder processing solutions for by subcutaneous injection and targets patients with neuropathy, with a second invention showing that the vaccine, pharmaceutical, and biotechnology type 1 and type 2 diabetes who require basal insulin neurotrophic hormones can act across the blood- industries. for the control of hyperglycemia. brain barrier to treat various brain disorders.

Albany Molecular Research, Inc (AMRI) Anabolic Laboratories Aurora Oncology Denver Colorado Springs Aurora www.amriglobal.com www.anaboliclabs.com Researching DT-EGF Toxic Fusion Protein for Performs services including drug discovery, Focused line of nutritional products, with state-of- treatment of bladder cancer. pharmaceutical development, and manufacturing of the-art pharmaceutical manufacturing facilities in active ingredients and pharmaceutical intermediates California and Colorado. Avidity, LLC for many of the world’s leading healthcare Aurora companies. Animal Health Options www.avidity.com Golden Develops and sells molecular affinity tools for Allergan, Inc. www.animalhealthoptions.com connecting molecules. Denver Animal Health Options has been offering high www.allergan.com quality antioxidants and nutritional supplements BaroFold, Inc. Multi-specialty health care company focused on that meet or exceed industry standards and provide Aurora discovering, developing and commercializing a noticeable benefit to dogs, cats and horses. www.barofold.com innovative pharmaceuticals, biologics, medical Pressure Enabled Protein Manufacturing devices and over-the-counter consumer products ApopLogic Pharmaceuticals, LLC (PreEMT™) technology to improve the tolerability, Aurora efficacy and safety of a wide variety of protein www.apoplogic.com therapeutics for bio-pharmaceutical companies, Focused on the development and commercialization research institutions, and government agencies. of Breceptin, a unique oncolytic drug for the COLORADO BIOSCIENCE ASSOCIATION MEMBER treatment of a wide range of solid tumors.

54 2013/2014 BIOSCIENCE COLORADO BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES

BioResponse, LLC Cedarburg Hauser Colorado Biolabs, Inc. Boulder Denver Frederick www.bioresponse.com www.cedarburghauser.com www.proferrin.com Researches, develops and commercializes dietary Full service API manufacturer of GMP materials Colorado Biolabs, Inc., the manufacturer of supplements for better absorption and functional that include small molecule API’s, adjuvants, Proferrin® ES and Proferrin® Forte, was founded foods. conjugates and toll manufacturing substances. in 1997 with a plan to develop and market Proferrin – an oral iron supplement made from heme iron BioServe Space Technologies Cell>Point polypeptide (HIP). Our proprietary process results Boulder Centennial in an oral iron product that provides an optimal www.colorado.edu/engineering/BioServe www.cellpointweb.com amount of HIP in a single tablet. Researches space life science with a wide range Develops novel radiopharmaceutical imaging of biotechnology applications involving animals, agents, radiotherapeutic agents and local regional Colorado Genetics, Inc. plants and microorganisms. Specializing in radio/chemotherapeutic drug delivery systems for Loveland conducting microgravity life science research and the diagnosis, treatment and post therapy asessment www.coloradogenetics.com designing and developing space flight hardware. of cancer, cardiovascular disease, infectious disease Provides livestock embryo-transfer research, artificial and metabolic diseases. insemination, embryo collection, freezing and Biosyntrx Inc. transfer, and international import and export services. Colorado Springs Cetya Therapeutics, Inc. www.biosyntrx.com Fort Collins Colorado Histo-Prep (CH-P) Develops nutraceuticals to address the micronutrient Founded to commercialize analogs of the class Fort Collins needs of the dry eye, cataract, macular degeneration, I isoform selective histone deacetylase inhibitor www.histoprep.com glaucoma and diabetic retinopathy patient. (HDACi) largazole, targeting unmet medical Produces high quality slides, clinical chemistry and needs, especially in oncology, neurodegeneration, hematology data and fully integrated and detailed Bolder BioTechnology, Inc. autoimmunity, and hemoglobinopathies. seamless pathology reports. Boulder www.bolderbio.com Cévan International, Inc. Colorado Micro Tech Uses advanced protein engineering technologies to Longmont Fort Collins create proprietary human protein pharmaceuticals www.cevan.com Focused on improving the workflow of the with enhanced therapeutic properties. Delivers vitamins, minerals and botanical extracts Anatomic Pathology laboratory of today as well as specialty nutriceutical formulations and by applying new and creative microfluidics Boulder Scientific Company antioxidants. technologies developed at Colorado State Mead University. www.bouldersci.com CHATA Biosystems Provides organometallic compounds to the Fort Collins Colorado Serum Company pharmaceutical, polymer, and specialty chemical www.chatasolutions.com Denver industries. Manufactures blended reagents, HPLC mobile www.colorado-serum.com phases, standards, buffers and dissolution media. Supplies veterinary biologic vaccines, instruments, Brotica laboratory reagents and serums for the veterinary Bellvue CHD Bioscience, Inc. industry. www.interval33.com Fort Collins Produces Interval33, a termite attractant which www.chdbioscience.com Corden Pharma works by producing the precise level of CO2 that Devlopeing a biocide which is a derivative of Boulder has been shown to attract termites, all natural and a natural molecule, is environmentally friendly www.cordenpharmacolorado.com animal safe. (“green”) and which has shown to be extremely Corden Pharma Colorado is the small to large-scale efficacious against a broad range of pathogens resource for peptides manufacturing. Cargill Research including the difficult to kill MRSA and c-difficile Fort Collins microbes that are the source of secondary infections Crestone, Inc. www.cargill.com in hospitals and other healthcare facilities. Boulder Develops, processes and markets science-based, www.crestonepharma.com health promoting ingredients for food and dietary ClinImmune Labs Drug discovery and development company focused supplement industries worldwide. Aurora on developing novel treatments for serious bacterial www.clinimmune.com infections. Catalent Pharma Solutions, Inc. Comprises five laboratories to provide services to Boulder kidney, heart, lung, pancreas, and hematopoietic Cytoskeleton, Inc. www.catalent.com stem cell transplant programs around the world. Denver Designs, manufactures and distributes specialized www.cytoskeleton.com medical products for fluid management of pleural Clovis Oncology, Inc. Offers kits for drug screening, signal transduction effusion and ascites. Boulder and cytoskeletal research specializing in the www.clovisoncology.com production of purified proteins and easy-to-use kits CBL (Chemical and Biopharmaceutical Focused on acquiring, developing and to study biochemical and cellular processes. Laboratories) commercializing innovative anti-cancer agents Boulder in the US, Europe and additional international DaVita Clinical Research (DCR) www.cblbiopharma.com markets. Denver Offering peptide starting materials, peptide www.davitaclinicalresearch.com intermediates, and industrial and commercial-scale Offers a complete array of early-phase study manufacturing of proprietary and generic GMP and capabilities through its two state-of-the-art research non-GMP peptides. facilities.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

BIOSCIENCE COLORADO 2013/2014 55 BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES

Efficas, Inc. Gonex Inc. HepQuant, LLC Boulder Fort Collins Aurora www.efficas.com www.cedusinc.com www.hepquant.com Develops bioactive products that offer natural relief Dedicated to the research, development and Designed test parameters using continuous variables from asthma and allergies in both humans and commercialization of hormonal based health care that may be correlated to clinical features or may be animals. strategies for both the human and companion followed over time to measure disease progression. animal markets including technology for sterilizing HepQuant-E is non-invasive, uses stable (not ELISA Tech companion animals with a single injection. radioactive) isotopes, and relies on natural, well- Aurora defined hepatic functions to measure the portal www.elisatech.com GlaxoSmithKline circulation. Provides immunoassays for the measurement of Denver cytokines, growth factors, and lipid inflammatory www.gsk.com Heska Corporation mediators. Produces medicines that treat six major disease Loveland areas – asthma, virus control, infections, mental www.heska.com Evolutionary Genomics (EG) health, diabetes and digestive conditions as well as Develops advanced diagnostics and specialty Lafayette vaccines and new treatments for cancer. products for veterinary practices that focus on www.evolgen.com companion animals. Identifies genes with a high likelihood of Gliacor Therapeutics LLC commercial value for downstream validation Fort Collins Hiberna Corporation through their proprietary Adapted Traits platform. Characterize the efficacy and safety of a novel Boulder series of antiinflammatory compounds to test their Pursuing the potential clinical application of Flagship Biosciences suitability as a new treatment for blocking the hibernation in order to slow metabolism thereby Westminster progression of Parkinson’s. extending survival limits in traumas that reduce www.flagshipbio.com oxygen to certain cells, e.g. in the heart and brain. Oncology drug development and tissue analytics GlobeImmune, Inc. and pathology services. Louisville Hospira, Inc. www.globeimmune.com Boulder FluTrends International Corporation Discovers, develops and manufactures potent, www.hospira.com Denver/Aurora targeted molecular immunotherapies called Supplies injectably generic and specialty www.flutrends.com Tarmogens, targeted antigens that distinguish pharmaceuticals. The Colorado site specializes in Biotechnology company that plans to develop diseased cells from normal cells, for the treatment the supply of active pharmaceutical ingredients for and commercialize products for the prevention of of cancer and infectious diseases. both internal and external markets. influenza. Great Lakes Pharmaceuticals iCanDxRx Gene Check, Inc. Denver Aurora Greeley www.glpharma.com Developing small molecules that stimulate the www.genecheck.com Development leading to commercialization of number and function of white blood cells. Gene Check is a diagnostic laboratory specializing innovative, effective product for prevention of in veterinary genetics. In addition, Gene Check catheter related microbial infections in clinical and ICVrx maintains a dynamic biotech research program, in outpatient settings Aurora including rare DNA sequence and SNP detection. www.icvrx.com Greffex, Inc./Isogenis, Inc. Drug reformulations and delivery systems targeting Genentech Aurora disorders of the central nervous system. Denver www.greffex.com www.gene.com Develops and produces new therapeutics for imuTEK LABORATORIES, INC. Using human genetic information to discover, immune suppression in humans to prevent Fort Collins develop, manufacture and commercialize medicines transplant rejection, improve gene therapy and www.imutek.com to treat patients with serious or life-threatening develop novel approaches to the treatment of Develops and markets bovine colostrums for medical conditions. autoimmune diseases. the nutrition and health products industry. The first manufacturer to receive an indication for Genesis Laboratories, Inc. Hauser Laboratories, Division of Microbac colostrum for the passive transfer of antibodies Wellington Boulder (immunoglobulins) in dry powder form. www.genesislabs.com www.hauserlabs.com Provides services to clients in the agrochemical and Provides research, development, and testing to InViragen, Inc. pharmaceutical industries, rodenticide research and the pharmaceutical, natural products, dietary Fort Collins development, as well as invasive species, zoonotic supplement, and medical device industries. www.inviragen.com disease, and conservation research. Focused on developing life-saving vaccines to HemoGenix protect against emerging infectious diseases GeneThera, Inc. Colorado Springs worldwide. Inviragen’s lead product is a vaccine to Westminster www.hemogenix.com protect against dengue fever. www.genethera.net Private contract research service and assay Develops and markets the latest molecular development laboratory specializing in developing technologies to eradicate “cross over” diseases such predictive in vitro assay platforms for primary as Johne’s Disease, Mad Cow Disease, Chronic human and animal target cells and stem cell Wasting Disease, and E.coli. Develops assay tests and hemotoxicity testing. vaccines to radicate the threat to humans of diseases transmitted up the food chain by cattle, elk and deer. COLORADO BIOSCIENCE ASSOCIATION MEMBER

56 2013/2014 BIOSCIENCE COLORADO BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES

InVitria Legacy BioDesign, LLC Merck & Co., Inc. Fort Collins Johnstown Denver www.invitria.com www.LegacyBioDesign.com www.merck.com InVitria develops, manufactures and markets a Conducts peptide and protein formulation and assay Merck and Co. produces products that cover a broad portfolio of high performance and well defined cell development work for biopharma companies. The range of areas, including heart and respiratory health, culture products and reagents used in bioprocessing, company also specializes in drug delivery and process infectious diseases, sun care and women’s health. And biopharmaceutical formulation, stem cell & development of biotechnology-based products. they focus their research on conditions that affect regenerative medicine, life science research and millions of people around the world – diseases like diagnostics. Life BioScience Inc. Alzheimer’s, diabetes and cancer – while building Longmont/Aurora strengths in new areas like biologics. Johnson & Johnson www.lifebioscience.com Denver Develop and commercialize innovative product miRagen Therapeutics www.jnj.com platforms. Boulder Manufactures a broad selection of health care www.miragentherapeutics.com products, as well as a provider of related services, for LifeTime Pharmaceuticals Improves patients’ lives by developing innovative the consumer, pharmaceutical, and medical devices Aurora microRNA (miRNA) based therapeutics for the and diagnostics markets. Developing several classes of small molecules that treatment of cardiovascular and muscle disease. stimulate production and function of WBCs miRNAs, are a recently discovered class of small JHPIEGO-Denver RNAs encoded in the genome, are short, single- Aurora Lohocla Research Corporation stranded RNA molecules. Designing and implementing effective, low-cost Aurora technologies – first product aimed at improving the www.lohocla.com Molecular BioSciences, Inc. management of postpartum hemorrhage. Research & development company that is at the Boulder forefront of discovery of medications for chronic pain, www.molbio.com Keen Ingredients, Inc. addictive and other mental health and neurological Manufactures products such as water soluble Louisville disorders. biotinylation reagents, vitamin derivatives, www.keeningredients.com crosslinking reagents, lipophilic probes, fluorophores, Develops process to de-bitter and stabilize quinoa MacLeod Pharmaceuticals, Inc. radioiodination reagents, and dendritic cores for naturally. Supplying the natural and gluten free Fort Collins preparing oligomers. industries with high quality Quinoa ingredients. www.macleodpharma.com Develops and manufactures anti-bacterial MonImmune Therapeutics Keeton Industries, Inc. pharmaceuticals for the veterinary industry. Fort Collins Wellington Developing a pipeline of repurposed compounds www.keetonaqua.com Martek Biosciences Corporation focused on monocyte regulation as vaccine adjuvants. Researches and develops biological water treatment, Boulder MonImmune intends to use currently approved aeration, ozone aeration, solids removal, biofiltration www.martek.com drugs with novel routes of administration to augment and other new technologies. Develops, manufactures and sells products from vaccine responses. This will allow an abbreviated microalgae. Products include nutritional supplements approval strategy for MonImmune products with a Kimball Genetics, Inc. and food ingredients which play a role in promoting minimum cash outlay when compared with de novo Denver mental and cardiovascular health. drug development strategies. www.kimballgenetics.com Genetic testing laboratory specializing in DNA MBC Pharma, Inc. Monsanto Company analysis for common genetic disorders that are Aurora Englewood preventable or can be treated. www.mbcpharma.com www.monsanto.com Biopharmaceutical company focused on discovering Leading global provider of technology-based KromaTid, Inc. and developing drugs for bone diseases such as cancer solutions and agricultural products that improve farm Fort Collins and osteoporosis. productivity and food quality. Monsanto remains www.kromatid.com focused on enabling both small-holder and large- Develops a method and kit using chromatid paints to MedImmune, LLC scale farmers to produce more from their land while improve detection of chromosomal inversions. The Denver conserving more of our world’s natural resources such improvement is important to medical applications www.medimmune.com as water and energy. such as cancer and birth defects. Strives to provide better medicines to patients, new medical options for physicians, and rewarding careers Mosaic Biosciences LABS, Inc. to employees. Denver/Aurora Denver mosaicbio.com www.labs-inc.org Mediral International, Inc. Start-up company focused on the development of Provides laboratory testing services focused on donor Denver innovative materials for tissue regeneration and repair. eligibiligy determination and final product safety; www.mediral.com infectious disease, microbiology, histocompatibility Develops, manufactures and sells homeopathic N30 Pharmaceuticals, LLC and environmental monitoring. pharmaceuticals taking into consideration antidotes. Boulder www.n30pharma.com MenoGeniX Drugs target nitric oxide reductase (NOR), the most Aurora important of which is s-nitrosoglutathione reductase www.menogenix.com (GSNOR) an enzyme of central importance in human Clinical stage biotechnology company focused on the health and disease. development of an approved drug, in a new indication, menopause, and the menopause-like symptoms that occur in certain breast and prostate cancer patients. COLORADO BIOSCIENCE ASSOCIATION MEMBER

BIOSCIENCE COLORADO 2013/2014 57 BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES

Nanoly Bioscience, Inc. OnKure, Inc. Quark Pharmaceuticals, Inc. Denver Longmont Boulder www.nanoly.info Exploring a highly potent and selective HDAC www.quarkpharma.com Developing a safe and proprietary polymer inhibitor as an anti-tumor drug. Discovers and develops siRNA drug candidates encapsulation to stabilize and protect therapeutic for treating Age-related Macular Degeneration and biological molecules, such as vaccines and enzymes, OPX Bioechnologies prevention of Acute Renal Failure. from below freezing to beyond tropical room Boulder temperatures. www.opxbiotechnologies.com Quicksilver Scientific Technology platform enables rapid, rational, and Lafayette NanoTrans Technologies robust optimization of microbes and bioprocesses to www.quicksilverscientific.com Aurora manufacture bioproducts with equivalent performance Clinical and environmental mercury lab and dietary Early-stage company focused on developing a novel and improved sustainability at lower cost compared to supplement manufacturing. ophthalmic drug delivery platform that will topically petroleum-based alternatives. deliver drug therapies to both the front and back of Rapid Scientific Solutions, LLC the eye. Pambec Laboratories, Inc. Golden Loveland www.rapid-scientific.com Nex Step, Inc. Researches drug discoveries in the field of AIDS. Premier pharmaceutical chemistry development Lakewood organization supporting the pharmaceutical and www.nexstepcorp.com Peak Analytical, Inc. biotechnology industries. Pharmacogenomic Decision Support Solutions. Golden www.peaklab.net Regenerative Sciences Inc. Novartis Pharmaceuticals Corporation Specializes in materials and chemical analysis. Broomfield Broomfield Performs a variety of molecular and atomic level www.regenexx.com www.novartis.com spectroscopic techniques to identify failures and Advances stem cell therapies through development Researches and develops products to protect and defects. of Regenexx™, an injection procedure to treat a wide improve health and well-being with core businesses in variety of painful conditions. pharmaceuticals, vaccines, consumer health, generics, PeptiVir eye care and animal health. Aurora Roche Custom Biotech peptivir.com Indianapolis, IN Novus Biologicals, Inc. PeptiVir is an early stage biopharmaceutical company www.roche-applied-science.com Littleton focused on the development and commercialization of Customize and supply reagents, products and www.novusbio.com a conformationally-constrained, synthetic peptide- services, customized to the quality and regulatory Develops, tests and markets antibodies for research based vaccine platform for the prevention of viral needs of the customer. of human diseases such as cancer, cardiovascular and diseases. neurological disorders. Rocky Mountain Biosystems, Inc. Pfizer Pharmaceutical Company Wheat Ridge Oberon FMR Centennial Research and development of transdermal Aurora www.pfizer.com pharmaceuticals and delivery systems, cosmetic www.oberonfmr.com Discovers, develops, manufactures, and markets devices, and tissue adhesives. Early stage company with proprietary technology prescription medicines for humans and animals. capable of producing a cost-effective, sustainably Rocky Mountain Diagnostics, Inc. produced protein meal. Oberon’s product serves as a PhosphoSolutions, LLC Colorado Springs fish meal replacement (FMR) or additive ingredient Aurora www.rmdiagnostics.com for animal feeds, primarily those destined for the www.phosphosolutions.com Provides immunodiagnostic assays and reagents for aquaculture industry. Designs and produces phosphoproteins solutions biogenic amines, research reagents, a CLIA certified using phosphor-specific antibodies. Phosphoproteins reference laboratory and contract manufacturing Omni Bio Pharmaceutical, Inc. are thought to be critical elements in neurological services. Greenwood Village diseases such as Alzheimer’s and in cancer. www.omnibiopharma.com Rocky Mountain Instrumental Laboratories Advancing broad-spectrum therapeutics targeting Pisces Molecular Fort Collins bacterial and viral diseases, biohazards, diabetes and Boulder www.rockylab.com transplant rejection. www.pisces-molecular.com Provides contract chromatographic and mass Focused on applying molecular genetics technology spectrometric analysis of pharmaceuticals (both OncoTherix to problems of fisheries and aquatic conservation traditional drugs and biotechnology products, such Aurora biology. as proteins and peptides and oligonucleotides), www.oncotherix.com veterinary and human endocrinology, and forensic Clinical stage oncology company focused on the Plura Biosciences Inc toxicology. development of InCell-RT (Intracellular radiotherapy) Lafayette for the treatment of locally-advanced cancers (LACs). www.plurabioscience.com Rocky Mountain Reagents, Inc. InCell-RT is a unique, DNA-ligated, nanometer- Specialized catalysts and chemicals that enable highly Golden scale intracellular radiotherapy with the potential to efficient, cost effective and green chemistry solutions www.rmreagents.com selectively kill cancer cells without causing damage in the manufacture of important life science products. Manufactures stains, culture media and chemistry to surrounding healthy tissue and without the solutions for the medical industry, as well as titration development of treatment resistance. Qgenta reagents, indicators, acids, bases, and a variety of Aurora chemicals for industrial uses. Harnessing innovative chemistry and biology in the development of molecular targeted agents for the treatment of cancer. COLORADO BIOSCIENCE ASSOCIATION MEMBER

58 2013/2014 BIOSCIENCE COLORADO BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES

RST Bioscience LLC SuviCa, Inc. Upsher-Smith Laboratoriess, Inc. Aurora Boulder Denver Develop and commercialize assay system to www.suvica.com www.upsher-smith.com monitor astronauts for viral infection during space Discovery and development of small molecules for Develops, manufactures and markets a vast flight. the treatment of cancer. range of prescription and over-the-counter products for cardiology, dermatology, Saigene Biotech Inc. Taiga Biotechnologies, Inc. women’s health and other areas. Denver Aurora Developing testing processes to identify harmful www.taigabiotech.com Venaxis Inc. algae blooms. Develops cellular, biologic and small molecule Castle Rock approaches to treat hematological diseases, www.venaxis.com Sandoz including cancers, immunodeficiencies and Primarily focused on advancing towards Broomfield autoimmune conditions. commercialization, our recently patented www.us.sandoz.com blood-based human diagnostic test, Focuses on pharmaceuticals, consumer health, Thermo Fisher Scientific AppyScore™ to aid in the diagnosis of human generics, eye care and animal health. Therapeutic Lafayette appendicitis and several novel reproduction categories inlcude anti-infectives, anti-arthritics, www.thermofisher.com drugs for use in high value animals. cardiovasculars, gastrointestinal agents & Scientific leadership and innovation in RNAi, Gene psychotherapeutics. Expression, qPCR/PCR Detection, and Molecular Ventria Bioscience Biology technologies come together with the Fort Collins Siva Therapeutics Inc Thermo Scientific Dharmacon, Open Biosystems, www.ventria.com Boulder ABgene, Finnzymes, and Fermentas product lines Develops a protein expression technology www.sivatherapeutics.com to provide world-leading solutions for gene analysis. platform called ExpressTec with a product Commercialize a proprietary therapeutic device pipeline in human nutrition and therapeutics. technology, based on gold nanorods, that can be TOLMAR, Inc. used both independently, and also in conjunction Fort Collins Ventrus Biosciences, Inc. with existing and new cancer drugs. www.tolmar.com Greenwood Village Develops and manufacturers both proprietary and www.ventrusbio.com STA Laboratories, Inc. generic pharmaceutical products with specific focus A specialty pharmaceutical company Longmont in therapeutic areas of dental, dermatology, and focused on the late-stage development and www.stalabs.com oncology. commercialization of gastroenterology Agricultural product testing laboratory that offers products. seed quality, genomics, plant health and diagnostic UBPBio services and products. Aurora Verdant BioSciences Corporation Manufactures and sells bioreagents related to the Denver Summit Plant Laboratories, Inc. ubiquitin-proteasome pathway. www.verdantbio.com Fort Collins Develops plant biochemical regulators www.plantlabs.com UCB, Inc. that provide superior plant performance Applies laboratory plant cloning and greenhouse Brussels, Belgium and unlock the productive power of plants technologies to produce planting stocks for www.ucb.com in markets from floriculture to industrial breeders, greenhouses, and field crop producers. Global biopharma focused on severe diseases with agriculture. operations in about 40 countries . ViroCyt, LLC Denver www.virocyt.com Focused on the commercialization of novel technologies that enable rapid quantification of viruses, such as the Virus Counter 2100

VetDC Fort Collins www.vet-dc.com Focused on development of novel devices, diagnostics and therapeutics for emerging veterinary markets.

Vitro Diagnostics, Inc. Golden www.vitrodiag.com Develops and commercializes products derived from human cell line research with a focus predominantly in stem cell R&D related to numerous diseases such as heart disease, stroke, Parkinson’s and Alzheimer’s disease.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

BIOSCIENCE COLORADO 2013/2014 59 BIOTECHNOLOGY, PHARMA, AND RELATED COMPANIES

Vitrolife, Inc. Carbo Analytics, LLC. BioFuels and Related Companies Englewood Fort Collins www.vitrolife.com www.carboanalytics.com Develops, manufactures and sells products and A1 Organics Commercial development of an online sugar systems for the preparation, cultivation and storage Eaton monitor with immediate application for more cost of human cells, tissue and organs. Product areas www.a1organics.com effective biofuels production. include fertility, transplantation and stem cell Composts and recycles organic by-products from Colorado Center for Biorefining and cultivation. various waste: yard trimmings, wood, biocides, agricultural by-products, manure, brewery by- Colorado Center for Biorefining and Biofuels Vitro Biopharma products, construction debris and food residuals. (C2B2) Golden Boulder www.vitrobiopharma.com Aerophase, Inc. www.c2b2web.org Owns US patents for production of FSH, Longmont A cooperative research and educational center immortalization of pituitary cells, and a cell line www.aerophase.com devoted to the conversion of biomass to fuels that produces beta islets for use in treatment of Research and Development of technologies and other products. Works to establish ground- diabetes. Vitro also owns a pending international that reduce environmental impact, and efficient breaking research and educational programs for the patent for generation of pluripotent stem cells. extraction system for biodiesel advancement of renewable energy technologies.

Vivaldi Biosciences BBI International Ciris Energy, Inc. Fort Collins Lakewood Centennial www.vivaldibiosciences.com www.bbibiofuels.com www.cirisenergy.com Developing advanced vaccines for prevention of Offers consulting services, including feasibility Start-up company developing a unique common seasonal influenza (“flu”) and emergent studies, market analyses, site & resource biotechnology for the conversion of fossil sources pandemic flu. assessments, economic impact studies, business of carbon such as low rank coals to natural gas and plans, industry benchmarking and industry surveys valuable chemicals. VRL Laboratories to the biofuels sector. Centennial Community Power Corporation www.vrl.net The Biocer Group of Companies Littleton Laboratory offers full service regulated donor Englewood www.gocpc.com eligibility testing for the human cell and tissue Emerging group of companies in Agriculture, Develops, commercializes and markets modular community. Forestry, and Biotechnology space. The group has biopower systems to meet the needs of distributed developed its own novel mechanism of multibillion energy consumers in both developing and developed Warren Analytical Laboratory dollar financing and is now prepared to launch a countries. Greeley series of emerging bioscience companies. www.warrenlab.com Front Range Energy, LLC Specializes in food microbiology, molecular BioFuel Energy Corporation Windsor biology, food chemistry, residue chemistry and Denver www.frontrangeenergy.com nutritional labeling. www.bfenergy.com Ethanol producer since 2006. Will process approx. Constructs large scale ethanol production facilities 40 million gallons of ethanol and 396,000 tons of Western States Biopharmaceuticals, Inc. in cooperation with Cargill and owns and operates wet distillers’ grain annually. Aurora two of the largest dry mill ethanol facilities in the www.westernstatesbiopharm.com United States. GeoSynFuels, LLC Novel anti-inflammatory therapeutics for Golden autoimmune diseases BioLynceus Biological Solutions www.geosynfuels.com Estes Park Develops a low-cost method to convert cellulosic Wildlife Pharmaceuticals, Inc. www.biolynceusturf.com biomass into fuel. The technology uses biological Fort Collins Working to help local governments, businesses and mechanisms set in a solid-state fermenter (“SSF”) www.wildpharm.com citizens to use environmentally safe alternatives to to convert the biomass into ethanol and/or methane. Providing pharmaceuticals for the safe and humane harsh toxic chemicals. Our Biological Solutions care of non-domestic and exotic wildlife species. renew the natural ecological system with Gevo, Inc. biologically sound products that do not contaminate Englewood YewSavin, Inc. soil or water resources. www.gevo.com Fort Collins Develops advanced biofuels like isobutanol, www.ajorganica.com Biomass Energy Foundation (BEF) butanol that will provide a sustainable path to the Develops chemical and biochemical technologies. Franktown replacement of petrochemicals like gasoline, diesel Successfully finished multi-step syntheses using biomassenergyfndn.org and jet fuel. Bromination, Grignard reaction, Suzuki coupling, Researches alternative fuels such as dried fruit pits, Amidation, and Esterification reactions. vegetable oil, wood, coffee grounds and the methods Intermountain CHP Center to produce biofuels. Boulder ZeoponiX, Inc. www.intermountainCHP.org Boulder BioVantage Resources, Inc. Formed by the U.S. Department of Energy to www.zeoponix.com Golden increase adoption of Combined heat and power Develops NASA originated technology to produce www.biovantageresources.com (CHP) in the states of Arizona, Colorado, New a soil amendment/fertilizer zeoponic material that Delivers algae-based bioremediation solutions Mexico, Utah, and Wyoming. utilizes nutrients more efficiently and reduces for municipal, industrial and agricultural wastewater nutrient leaching into the environment. treatment.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

60 2013/2014 BIOSCIENCE COLORADO

Research and Education Institutions

LUCA Technologies, Inc. PureVision Technology, Inc. Golden Fort Lupton Research and Education Institutions www.lucatechnologies.com www.purevisiontechnology.com Researches the ability of naturally occurring Develops a carbon-neutral biomass Advanced Diagnostic Laboratories (Adx) at microorganisms to convert under-utilized domestic fractionation technology that converts National Jewish Health oil, organic-rich shale and coal resources to clean, cellulosic biomass into sugars, energy and Denver renewable energy. fiber that are bio-based raw materials to make www.njlabs.org many industrial and consumer products. National Jewish Health is known worldwide Novo Energy LLC for treatment of patients with respiratory, Fort Collins Solix Biofuels, Inc. cardiac, immune and related disorders, and for www.novoenergyllc.com Fort Collins groundbreaking medical research. The Advanced Colorado-based renewable energy company that www.solixbiofuels.com Diagnostic Laboratories provide innovative services provides state-of-the-art technology, equipment, and Develops massively scaleable photo- within the extraordinary clinical and research project support services for the renewable energy bioreactors for the production of biodiesel environment of National Jewish Health. Leveraging and solid waste disposal industries. and other valuable bio-commodities from our expertise in both laboratory medicine and algae oil. personalized medicine, we offer an ever-expanding Nuemann Systems Group menu of diagnostic tests, as well as contract Colorado Springs Sterling Ethanol, LLC research services. Our laboratories are CAP and www.neumannsystemsgroup.com Sterling CLIA certified, and have earned the prestigious Research, technology and product development www.sterlingethanol.com CAP 15189℠ accreditation. focused on product prototyping of gas-liquid Produces 42 million gallons of ethanol contactor systems for chemical processing and annually, using the distiller’s grain produced Biofrontiers Institute emissions control. as a co-product of ethanol to the areas cattle Boulder feeders for its high protein levels. biofrontiers.colorado.edu PolyNEW, Inc. State-of-the art research and education facility Golden/Aurora Sundrop Fuels, Inc. that links the basic sciences, engineering, clinical www.polynewinc.com Louisville practice, and industry at the University of Developed a new class of PLA bioplastics which www.sundropfuels.com Colorado’s Boulder campus. it terms “ecobionanocomposites.” These are A solar gasification-based renewable energy nanocomposites from 100% renewable resources company. Biological Sciences Curriculum Study (BSCS) that could be used in a wide variety of applications Colorado Springs including medical device applications. ZeaChem www.bscs.org Lakewood A nonprofit corporation that endeavors to improve Power Ecalene Fuels, Inc. www.zeachem.com all students’ understanding of science and Arvada Developed a cellulose-based biorefinery technology by developing exemplary curricular powerecalene.com platform capable of producing third- materials, supporting their widespread and effective Exclusive licensor of a patented nano-catalyst generation ethanol fuel and intermediate use, providing professional development, and technology that efficiently converts “syngas” or chemicals. Our indirect approach leapfrogs conducting research and evaluation studies. “producer gas” into a pr emium mixed alcohol the yield and carbon dioxide (CO2) problems transportation fuel called Ecalene™. Ecalene™ is associated with traditional and cellulosic Bonfils Blood Center usable as a stand-alone fuel for cars, trucks, buses, based ethanol processes. Denver jet aircraft and boats. www.bonfils.org One of the nation’s leading community blood centers through their commitment to quality service, innovation, research and technology. They offer a full range of blood products and services to healthcare partners including supplying rare blood units or helping to determine the best cross-matched unit to endure the best possible patient outcomes.

Centers for Disease Control and Prevention/ Division of Vector-Borne Infectious Disease Fort Collins www.cdc.gov/ncidod/dvbid The Division of Vector-Borne Infectious Diseases (DVBID) is part of the U.S. Centers for Disease Control and Prevention (CDC). CDC is the lead federal agency for protecting the health and safety of people at home and abroad. DVBID serves as a national and international reference center for vector- borne viral and bacterial diseases, such as West Nile virus, Lyme disease, plague, tularemia, yellow fever and dengue. It coordinates national disease monitoring activities, conducts field and laboratory research, responds to epidemic situations, develops strategies for disease prevention and control, provides diagnostic reference and epidemiologic consultation, and conducts technical assistance and professional training activities.

BIOSCIENCE COLORADO 2013/2014 61 Research and Education Institutions

Children’s Hospital Colorado Colorado State University Colorado Institute for Drug, Device and Aurora Fort Collins, Pueblo Diagnostic Development (CID4) www.childrenscolorado.org www.colostate.edu Aurora Children’s Hospital Colorado has been ranked As one of the nation’s leading research www.cid4.com for more than a decade as one of the best universities, Colorado State University is CID4 provides management expertise to children’s hospitals nationally in U.S. News committed to realizing its vision as a 21st century efficiently transform emerging life science & World Report, and as the consistent choice land-grant university. CSU leads the world technologies into commercial successes. We eight years in a row by area physicians for in such areas as infectious disease research, do this by identifying and funding potential the care of their loved ones. Founded in 1908, atmospheric science and environmental science. opportunities, and by utilizing an advanced Children’s Colorado is a private, not-for-profit Its faculty members are tackling such issues leadership team to ensure speed to market, pediatric health-care network dedicated 100 as the reemergence of tuberculosis, the brown putting new products and services to work percent to caring for kids. With 1,130 pediatric cloud of air pollution in Asian cities, severe where they are needed. specialists and more than 2,300 full-time weather forecasting, nutrition and wellness, and employees, Children’s Colorado is home to bioterrorism. In addition to its excellent programs Denver Botanic Gardens a number of nationally and internationally in those areas, CSU offers among the very best Denver recognized medical programs. professional programs in the United States in www.botanicgardens.org areas like veterinary medicine, occupational One of the top-ranked botanical gardens in the Colorado Center for Drug Discovery therapy, journalism, agriculture and construction US, Denver Botanic Gardens offers spectacular (C2D2) management. Its programs in the arts, humanities plant displays and unlimited opportunities for Fort Collins and social sciences are also outstanding lifelong learning. c2d2.org A non-profit organization funded through the CSU Research Innovation Center Denver Museum of Nature and Science State of Colorado. The organization promotes Fort Collins Denver drug discovery research with Colorado through csuric.org www.dmns.org a combination of funding, medicinal chemistry The Research Innovation Center (RIC) The Denver Museum of Nature & Science is and modeling expertise. serves as a vehicle to perform collaborative the Rocky Mountain region’s leading resource translational-stage research with CSU’s life for informal science education. A variety Colorado School of Mines sciences community of researchers, giving it the of exhibitions, programs, and activities help Golden promise to become the birthplace of medical Museum visitors experience the natural www.mines.edu breakthroughs. wonders of Colorado, Earth, and the universe. A public research university internationally recognized for its leadership in engineering, Community College of Aurora (CCA) applied science and related disciplines, with a Aurora special emphasis on the Earth and its resources. www.ccaurora.edu These programs, with strong interdisciplinary CCA provides lifelong educational opportunities, linkages across the campus, have led to the prepares the current and future workforce, and integration of bioscience and biotechnology promotes excellence in teaching, learning and into educational and scholarly activities. CSM service. CCA offers a unique Biotechnology has created a Bioengineering and Life Science Technician Research and Development Certificate Program that draws upon faculty and students designed to train highly skilled lab personnel for from all of the academic units. the biotech industry.

62 2013/2014 BIOSCIENCE COLORADO Research and Education Institutions

Denver School of Science and Technology National Institute of Standards and Rocky Mountain Innosphere Denver Technology (NIST) Fort Collins www.dsstpublicschools.org Boulder www.rmi2.org DSST Public Schools transforms urban public www.nist.gov At Rocky Mountain Innosphere (RMI), we education by eliminating educational inequity and NIST is a non-regulatory federal agency that operates are helping new clean energy, technology and preparing all students for success in college and eight different science and advanced technology scientific startup companies turn their great the 21st century. By creating a powerful learning research divisions in Colorado. NIST’s list of ideas into great businesses. These businesses, in community centered on core values and a shared research accomplishments includes a NIST senior turn, create high wage job opportunities for the commitment to academic excellence, DSST will scientist winning the Nobel Prize in 2001 for creating community and fuel the growth of the industries double the number of college ready graduates in the world’s first “Bose-Einstein condensate.” In 2003 of the future. the Denver Public School system by 2020. Over another NIST scientist won a MacArthur Fellowship the past decade, DSST has become one of the for discovering a new quantum gas and was named Rose Medical Center leading open enrollment STEM schools (Science, by Science as one of the top ten scientific advances Denver Technology, Engineering and Mathematics) in the of the year. www.rosemed.com U.S. and has become a destination for educators Has earned a reputation as Denver’s “Baby nationwide. National Jewish Health Hospital” while becoming a leader in Denver comprehensive women’s services, internal Denver Research Institute www.njhealth.org medicine, endoscopy, heart and vascular care, Denver National Jewish Health, the nation’s #1 respiratory orthopedics and total joint replacement, bariatric denver-research.org hospital in the US, attracts thousands of adult and surgery, sports medicine and aesthetic surgery. Denver Research Institute (DRI), founded in pediatric patients each year who come to us to team 1997, serves as the non-profit organization up with our expert physicians and researchers and Rocky Vista University College of affiliated with the VA Eastern Colorado Health seek treatment for respiratory, cardiac, immune Osteopathic Medicine (RVUCOM) Care System. It is dedicated to research and its and related conditions. National Jewish Health Parker associated educational and scientific endeavors. is also one of the most influential independent www.rockyvistauniversity.org biomedical research centers in the world. More than Rocky Vista University College of Osteopathic Front Range Community College 100 faculty members conduct basic, translational, Medicine (RVUCOM ) is one of the newest of Brighton, Fort Collins, Longmont and Westminster and clinical research in immunology, respiratory the 28 colleges of osteopathic medicine currently www.frontrange.edu medicine, allergy, cancer, and cell and molecular established or in development in the United Front Range Community College, Colorado’s biology. National Jewish Health ranks among the States. With five departments – biomedical largest community college, provides instruction, top ten percent of all institutions for NIH support sciences, structural medicine, primary care, in both general education and occupational areas, and for the impact of its research papers in the fields Osteopathic Principles and Practices, Specialty which may lead to a certificate, an associate of Molecular Biology, Genetics, and Biology and Medicine and Medical Informatics the faculty degree, or transfer to a four-year institution. Biochemistry. and staff of RVUCOM are committed to The college also provides college preparatory osteopathic philosophy and heritage, and to education, non-credit instruction for personal and National Renewable Energy Laboratory advancing the science and the art of the practice professional development, and workplace skill Golden of osteopathic medicine. development. With campuses located in Fort www.nrel.gov Collins, Longmont and Westminster, the college is The nation’s primary laboratory for renewable energy Scientific Education & Research Institute proud of its many partnerships to provide quality and energy efficiency research and development (SERI) programs that are responsive to the needs of its (R&D). NREL’s mission and strategy are focused Thornton local communities. on advancing the U.S. Department of Energy’s and www.theseri.com our nation’s energy goals. NREL’s R&D areas of SERI is a unique institute, which combines an Keystone Symposia on Molecular and expertise are: renewable electricity (solar, wind, orthopedic clinic, specializing in spine surgery, Cellular Biology biomass, geothermal), renewable fuels (biomass, with a clinical research unit and and education Silverthorne hydrogen), integrated energy system engineering and and training program. Our facility has available www.keystonesymposia.org testing (buildings, electric systems and transportation to rent an amphitheater with full AV setup for A non-profit organization that serves as a catalyst infrastructures), and strategic development and presentations, as well as a bioskills lab with for the advancement of biomedical and life analysis (economic, financial, and market analysis, cadaveric dissection capabilities. We host a sciences by connecting scientists within and planning and portfolio prioritization). variety of educational programs including across disciplines at conferences and workshops summer science camps. Additionally we host a held at venues that create an environment Regis University large number of training programs sponsored by conducive to information exchange, generation of Denver surgical and medical companies. new ideas, and acceleration of applications that www.regis.edu benefit society. The School of Pharmacy aspires to be the foremost Swedish Medical Center school of pharmacy in the United States where Englewood students are nurtured and developed to become www.swedishhospital.com leaders in pharmacy practice, research, education, Level I Trauma Center, serves as the region’s and public service. As a result, students graduate as referral center for neurotrauma and is a professionals who are knowledgeable, skillful, and recognized leader in the treatment of stroke. An principled, and who are able to make a positive impact acute care hospital with 368 licensed beds. on the dramatically changing role of pharmacists in our transforming society. They are educated to be committed to excellence in healthcare, evidenced not only by their knowledge and abilities, but also by their quality of care, integrity, compassion, respect, advocacy, initiative, service and leadership. To achieve these goals, faculty members are dedicated to providing innovative practice models, exploring novel applications of basic and clinical research, and illustrating the value of lifelong learning.

BIOSCIENCE COLORADO 2013/2014 63 Research and Education Institutions

United States Geological Survey (USGS) - University of Denver Member Foundations Center for Biological Informatics Denver Denver www.du.edu Boettcher Foundation biology.usgs.gov/cbi Strives to provide the most modern educational Webb-Waring Biomedical Research Program The Center for Biological Informatics, at the and research facilities in the life sciences. Their Denver Denver Federal Center, operates the national history spans the Denver Research Institute’s www.boettcherfoundation.org Biological Information Infrastructure (NBII). development of the first NASA life monitoring “Founded by the Boettcher Family in 1937 to This is the first comprehensive electronic gateway sensors, the establishment of a state-of-the-art effectively assist, encourage and promote quality dedicated exclusively to biological science data forensics laboratory, to the 2003 acquisition of of life for the citizens of Colorado, the Boettcher and information from sources throughout the the Eleanor Roosevelt Institute with pioneering Foundation invests in education, community world. efforts in genomics and bioinformatics. In services, health, and arts & culture through merit 2004, the School of Engineering and Computer University of Colorado Science unveiled Colorado’s first undergraduate awards, scholarships and capital grants. In 2008, Boulder, Denver, Aurora, Colorado Springs program in Bioinformatics and a master’s the Webb-Waring Institute became a part of the www.cu.edu degree in Bioengineering. The interdisciplinary University of Colorado and is now known as the The University of Colorado System’s 52,000 mission of the University enabled the Webb-Waring Center. The Boettcher Foundation students and 28,000 faculty and staff contribute Department of Biology to launch new emphases was entrusted with the stewardship of the Webb- to every facet of life in Colorado. The state’s in Bioengineering, Biophysics and Cognitive Waring Foundation’s assets. Through an innovative economic vitality, educated workforce, Neuroscience designed for molecular biology agreement between the Boettcher Foundation, the entrepreneurial climate, cultural capital, health majors. In addition to strong and quality Webb-Waring Foundation and the University of care delivery, and scientific explorations all curricula, bioengineering and life sciences at Colorado, a new funding area was established at rely on the driving force of a vigorous state DU carry multimillion-dollar-a-year research the Boettcher Foundation that supports the work of university. By working with other CU academic studies in the creation of new knowledge and early-career investigators in the biomedical sciences and research units, as well as local, state, and leading edge biotechnologies to improve quality in Colorado.” federal funding agencies, commercial business, of life for a worldwide community. and nonprofit organizations, CU is creating a Childrens Hospital Colorado Foundation collaborative synergy in important areas that will University of Northern Colorado Aurora better the wellness of society. The CU Institute of Greeley Bioenergetics, the Colorado Initiative in Molecular www.childrenscoloradofoundation.org www.unco.edu In 1978, Children’s Hospital Colorado Foundation Biotechnology, the Center for Computational University of Northern Colorado (UNC) is a was formally established as a separate charitable Biology, and the Center for Pharmaceutical multipurpose institution with a wide range of 501(c)(3) organization dedicated solely to Biotechnology attract intellectual strength to graduate and undergraduate programs. The Colorado, provide new educational opportunities, university’s mission is to prepare individuals advancing the mission of Children’s Hospital and inspire innovative health care advances. for advanced study, professional careers, and Colorado. Research and teaching hospitals affiliated with the positions of leadership. University of Colorado include: The University CSU Ventures, Inc. of Colorado Hospital, The Children’s Hospital, Work, Education and Lifelong Learning Fort Collins National Jewish Medical and Research Center, Simulation (WELLS) Center www.csuventures.org Denver Health and the VA Medical Center. Aurora “CSU Ventures, Inc. (CSUV) is a 501(c)(3) www.wellssimulationcenter.org non-profit corporation that actively supports University of Colorado Cancer Center Fund For the first time in Colorado, one facility and promotes the transfer of Colorado State Denver offers a complete array of state-of-the-art University (CSU) research and innovations into www.amc.org patient simulation tools for building clinical the marketplace for the benefit of society. CSU AMC Cancer Research Center, is dedicated to knowledge. Even more exciting, high-speed Ventures serves CSU faculty and researchers who raising awareness and funds for the University of datacasting technology makes this unique wish to protect and license intellectual property; Colorado Cancer Center to support its outstanding resource available remotely. Students, faculty builds relationships with industries and investors programs in cancer prevention, care, education, and practicing nurses and physicians from seeking to engage with CSU; and leverages CSU research and service to the nation. The University throughout Colorado can enhance their innovation to foster business formation and enhance of Colorado Cancer Center is the only National diagnostic and clinical skills at the WELLS regional economic vitality. Cancer Institute-designated Comprehensive Can- Center either on-site or on-line.Housed in the cer Center in the Rocky Mountain Region, one of new Bioscience East building at Fitzsimons, University of Colorado Foundation only 40 in the country. the WELLS Center represents a unique collaboration among educators, providers and Boulder University of Colorado Health policymakers. www.cufund.org Loveland, Fort Collins The University of Colorado Foundation is a www.pvhs.org privately governed nonprofit corporation whose Poudre Valley Health System (PVHS) and the mission is to support the University of Colorado. University of Colorado Hospital (UCH) finalized As a valued and trusted partner, the University of a joint operating agreement in early 2012 that Colorado Foundation generates the private support creates a health system its leaders say will widen needed in perpetuity for CU to achieve international health care services and provide unparalleled preeminence as a public research university. Our patient care in the Rocky Mountain region. Called donors enable CU to reach its full potential to University of Colorado Health, the new system transform lives world-wide through education, combines one of the top-performing community research, clinical care and community service. health systems in the nation with the highest- ranked academic medical center in quality in the country. With annual net revenue of $1.5 billion, it will be one of the region’s largest locally-owned health systems and, with nearly 10,000 employees, one of Colorado’s largest employers.

COLORADO BIOSCIENCE ASSOCIATION MEMBER

64 2013/2014 BIOSCIENCE COLORADO SERVICE PROVIDERS

CARE Research LLC/Colorado Histo-Prep Member Service Providers www.histoprep.com Economic Development

Architecture CPC Clinical Research Adams County Economic Development, www.cpcmed.org Inc. (ACED) BURKETTDESIGN, Inc. www.adamscountyed.com www.burkettdesign.com DaVita Clinical Research (DCR) www.davitaclinicalresearch.com Aurora Economic Development Council Construction and Facilities www.auroraedc.com High Quality Research, LLC (HQR) CH2M Hill www.hqrllc.com Boulder Economic Council www.ch2m.com www.bouldereconomiccouncil.org Microbial Research, Inc. CRB Engineers and Builders www.microbialresearch.com Broomfield Economic Development www.crbusa.com Corporation (BEDC) MPI Research www.broomfieldedc.com Facility Planning Arts www.mpiresearch.com www.planningartsinc.com Canadian Consulate NextGen Pharma Technologies, Inc. www.international.gc.ca Howell Construction www.nextgenpharma.com www.howellconst.com City & County of Broomfield Novella Clinical www.broomfield.org The Whiting-Turner Contracting Co. www.novellaclinical.com www.whiting-turner.com City of Westminster PCM TRIALS www.ci.westminster.co.us Consulting - General Business www.pcmtrials.com City of Westminster Economic CBIZ MHM, LLC Plato BioPharma, Inc. Development Office www.cbiz.com platobiopharma.com www.ci.westminster.co.us

Colorado Small Business Development Premier Laboratory, LLC Colorado Small Business Development Center www.premierlab.com Center www.coloradosbdc.org www.coloradosbdc.org Pre-Clinical Research Services, Inc. Neil Burris & Associates www.preclinicalresearch.com Colorado Springs Regional Business [email protected] Alliance www.coloradospringsbusinessalliance.com Consulting - Regulatory, Commercialization and Development Colorado Office of Economic Development and International Trade BioNimbus, Inc. (OEDIT) www.bionimbus.com GLP/non-GLP Services Medical imaging Fluoroscopy www.advancecolorado.com Experimental Surgery Angiography Medical devices Decus Biomedical Ultrasound/Echo Denver South Economic Development www.decusbiomedical.com Proof of Concept Device V&V Labs Toxicology Partnership www.denversouthedp.org Emerson Consultants, Inc. Cardiovascular Devices Pilot/Acute/MTD GI/Ortho/Thoracic 14 and 28 Day www.emersonconsultants.com Osteoarthritis Jefferson County EDC Pharmacokinetics www.jeffco.org Evolve Biosciences LLC (PK/PD/TK) www.evolvebiosciences.com www.PreClinicalResearch.com Metro Denver Economic Development Corporation Health Perls www.metrodenver.org (303) 755-2900 Pyxant Labs, Inc. www.pyxant.com South Metro Denver Chamber of Latin American Sale Alliance Commerce www.lasa-alliance.com Contract Manufacturing/ www.bestchamber.com Design Organizations Reglera, LLC Town of Parker www.reglera.com Evergreen Research, Inc. www.parkeronline.org www.evergreenresearch.com Clinipace Worldwide/Regulus Finance, Investment and Financial Services Pharmaceutical Consulting, Inc. Mountainside Medical www.reguluspharma.com www.mountainsidemed.com Commerce Bank www.commercebank.com Technical Safety Services Vention Medical www.techsafety.com www.ventionmedical.com The Conafay Group www.conafaygroup.com Contract Research Organizations Distribution, Packaging and Sales Force Eide Bailly LLP Absolute Science, Inc CGL - Concert Group Logistics www.eidebailly.com www.absolutescience.com www.cglship.com EKS&H (Ehrhardt Keefe Steiner & Hottman) CBR International Corporation Pozzetta Scientific www.eksh.com www.cbrintl.com www.pozzettascientific.com

BIOSCIENCE COLORADO 2013/2014 65 SERVICE PROVIDERS

Ernst & Young Marketing, Communications, Events and www.ey.com Public Relations Real Estate

Headwaters MB Absolutely Public Relations Fitzsimons Life Science District www.headwatersmb.com www.absolutelypr.com www.colobio.com

High Country Venture LLC Aegis Creative Forest City Stapleton www.coloradofund1.com www.aegiscreative.com www.forestcity.net

Independent Investment Research The Bawmann Group Forte Commercial Real Estate www.independentresearch.com.au www.morethanpr.com www.fortecre.com

Morgenthaler Ventures Biolexica Jones Lang LaSalle www.morgenthaler.com www.biolexica.com www.joneslanglasalle.com

OnBioVC Recruiting, Placement, and Workforce www.OnBioVC.com Aerotek Inc. Silicon Valley Bank (SVB Financial Group) www.aerotek.com www.svb.com Arapahoe/Douglas Works! Workforce Incubator Center www.adworks.org Colorado Springs Technology Incubator (CSTI) www.cstionline.org Jefferson County Workforce Center Fitzsimons Life Science District www.jeffcoworkforce.org www.FitzScience.com Kelly Scientific Resources Innovation Center of the Rockies www.kellyscientific.com www.innovationcenteroftherockies.com Lab Support Rocky Mountain Innosphere www.labsupport.com www.rmi2.org Burns Marketing Communications www.burnsmarketing.com Mountain States Employment Council Insurance www.msec.org Business Wire The Travelers Companies, Inc. www.businesswire.com www.travelers.com Global Prairie The Wright Group, Inc. www.global-prairie.com Need compensation data? www.twgservices.com Contact MSEC regarding our Griff/SMC Medical Marketing annual Biosciences Survey. Legal Services Communications www.griffsmc.com MSEC has been a leader in surveys for Cooley LLP over four decades. Are you a member? www.cooley.com Growl Healthcare Agency www.GrowlAgency.com Collective IP www.collectiveip.com Planning Partners International, LLC www.ppimeetings.com Dorsey & Whitney LLP 800.884.1328 • MSEC.org www.dorsey.com RobinBond Media www.robinbondmedia.com Faegre Baker Daniels LLP Prime-Core, Inc. www.faegrebd.com Sprint Press www.prime-core.com www.sprintdenver.com Fennemore Craig PC Supplier/Equipment/Disposal-Lab www.FennemoreCraig.com The Text Doctor LLC www.textdoctor.com Agilent Technologies Gross Hartman LLC www.agilent.com grosshartmanlaw.com Ubiquity Group www.ubiquity-design.com Colorado Medical Waste, Inc. Hogan Lovells US LLP www.coloradomedicalwaste.com www.hoganlovells.com Unbridled Solutions www.unbridledsolutions.com Fisher Scientific Morrison & Foerster LLP www.fishersci.com www.mofo.com Public Policy Haldeman Homme Inc Polsinelli Shughart PC PhRMA www.haldemanhomme.com www.polsinelli.com www.phrma.org Sheridan Ross PC Thermo Fisher Scientific, Inc. www.sheridanross.com We Work for Health www.dharmacon.com www.weworkforhealth.org Snell & Wilmer www.swlaw.com

66 2013/2014 BIOSCIENCE COLORADO Where bioscience means business Aurora is home to the Anschutz Medical Campus and Fitzsimons Life Science District, one of the largest bioscience redevelopment projects in the United States. The 578-acre site is undergoing a $5.2 billion transformation that will result in more than 18.5 million square-feet of space dedicated to excellence in health care, education and research.

Visit www.auroraedc.com for more information on Colorado incentives, our highly skilled workforce, and other resources that make Aurora the location for your next bioscience venture.

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Michael Ehrman • 303.371.0566 • [email protected] Where business and science come together to develop innovative Where business and science come together to develop innovative technologies that will change the future of healthcare! technologies that will change the future of healthcare!

Whether you start in the BioBusiness Incubator, move into the new Accelerator orWhether into a youstate-of-the start in theart labBioBusiness facility, everything Incubator, you move need into is the located new withinAccelerator our or184-acre into a state-of-theLife Science artDistrict lab facility, in Aurora, everything Colorado: you need is located within our 184-acre Life Science District in Aurora, Colorado:

BioBusiness Incubator with pre-built labs, furnished of�ices, shared BioBusiness conference Incubatorrooms and with equipment pre-built labs, furnished of�ices, shared • conference• Accelerator rooms for build-to-suit and equipment opportunities • • Accelerator • Adjacent forto University build-to-suit of Colorado’s opportunities Anschutz Medical Campus • Adjacent • Access toto UniversityUniversity ofcore Colorado’s laboratories Anschutz Medical Campus • Access • Enhanced to University life style core opportunities laboratories with close proximity • Enhanced to parks, lifeshops, style and opportunities residential communitieswith close proximity to parks, shops, and residential communities

Join the conversation at For more information, www.FitzScience.comJoin the conversation at contactFor more [email protected] information, www.FitzScience.com orcontact call 720-859-4108 [email protected] or call 720-859-4108