CONNECTIONS Bringing the Bioscience Community Together with Critical Resources

COLORADO

2015-2016

P. 16 Connection Points MAKING in Colorado CONNECTIONS Bringing the bioscience community together with critical resources

P. 11 Changing the P. 40 Face of Healthcare Colorado Bioscience Industry Directory

P. 6 The Path to Commercialization 2015-2016 BIOSCIENCE COLORADO 1 2 BIOSCIENCE COLORADO 2015-2016 COLORADO

2015 - 2016 » MAKING CONNECTIONS IN THIS ISSUE

06 The Path to Commercialization 11 Merging Technologies and Disciplines: Changing the Face of Healthcare

16 Connection Points in Colorado P. 24 18 Webb-Waring Biomedical Research Program 20 Bridging the Gap from Discovery to Commercial Success: Colorado’s Supportive Ecosystem 24 Incubators Help Bioscience Companies Develop and Commercialize Innovations 28 Interconnected: Colorado’s Clinical Assets 30 Colorado by the Numbers 34 Grant Programs: Innovation Engines 40 Bioscience Industry Directory

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2015-2016 BIOSCIENCE COLORADO 3

elcome to the Colorado BioScience Association’s twelft h anniversary edition of Bioscience Colorado. This publication is a key resource for companies, investors and economic developers, and has become THE go-to source for our industry. With a total audience of over 8,000, including online impressions, this publication is one of the industry’s greatest voices—locally, nationally and internationally. Colorado’s bioscience cluster is thriving, with nearly 600 bioscience companies that are moving from early-stage research and development through clinical trials and into full- fledged commercialization companies. There are nearly 600 commercial products originating from Colorado’s bioscience industry. That is a testament to the level of commitment, resources, networks and expertise within Colorado’s bioscience eco-system to support and facilitate the formation of new companies, continued growth and the ability to get a product to market right here in Colorado. Companies in Colorado have created important life-saving therapies and medical technologies. We are proud to have continually grown the industry and are excited for what the future brings. Bioscience in Colorado truly is driving innovation, creating jobs and improving lives!

April Giles President and CEO Colorado BioScience Association

Published by: Designed by: Colorado BioScience Association The Bawmann Group 600 Grant Street, Suite 306 3511 Ringsby Court, Suite 101 Denver, CO 80203 Denver, CO 80216 www.cobioscience.com www.morethanpr.com 303.592.4073 303.320.7790

4 BIOSCIENCE COLORADO 2015-2016 2015-2016 BIOSCIENCE COLORADO 5 THEPATH TO COMMERCIALIZATION

Common themes help Colorado companies achieve success

WRITTEN BY JEANNE MC ADARA-BERKOWITZ, PH D

6 BIOSCIENCE COLORADO 2015-2016 it down for coff ee with your average Colorado bioscience “They quickly realized they had stumbled upon a very insider, and inevitably the discussion will turn to the valuable platform technology for human systemic drug industry cluster’s progress since 2003. That is the year the delivery,” says TOLMAR’s current CEO Mike Duncan. Around Governor’s off ice released what is now known aff ectionately that time, the company began to build a more diverse as “the Battelle Report.” Most agree that the flurry of activity product portfolio, acquiring a dermatology business and following that report has spurred immensely positive and developing a prostate cancer therapeutic it recognized lasting changes in the state. However, the prevailing view could be a blockbuster. TOLMAR also holds that Colorado’s relatively young industry cluster “We wanted to avoid a big-pharma buyout, because Eligard remains start-up heavy, and that companies still have to › 25 marketed had such huge potential,” says Duncan. “We didn’t want to prescription products leave the state in search of the funding and partnerships be acquired for one product and then have the rest of our they need to get them to the next stage. › 25 additional product business divested and sold off . We knew that we’d need launches by 2020 Despite that view, ample evidence suggests that Colorado to diversify in order to protect ourselves from being too › 450 employees bioscience is approaching a new milestone in its evolution. attractive as an acquisition target.” › 7 facilities in With an increasing number of homegrown product The strategy has paid off . Since that time, through a series of northern Colorado approvals and commercial successes, more companies are acquisitions and partnerships, TOLMAR’s current portfolio demonstrating that it is possible to successfully navigate has grown to more than 25 marketed prescription products, the corporate life cycle from concept to commercialization with 25 additional product launches planned by the year without leaving the state. 2020. Eligard is now the world’s second-leading treatment Balancing diversity and focus for prostate cancer. The company employs more than 450 At first it can be hard to identify a common thread to explain employees in seven facilities around northern Colorado, the success behind this eclectic collection of medical device, and a large additional manufacturing plant is scheduled to pharmaceutical and biotechnology companies. But look open in 2016. deeper, and certain patterns emerge. Development of a Colorado Springs-based Spectranetics has also found suc- platform technology with the potential for wide-ranging cess in generating a diverse product line based on a focused applications is one example—many companies cite a platform. Spectranetics was founded 30 years ago to pursue commitment to focused product diversification as a critical the clinical development of excimer laser technology At Spectranetics, a teammate factor both to their commercial success and, ultimately, to coming out of research at the Air Force Academy. inspects the luer connection their ability to remain independent. Today, the product lines of the company’s two principal on a QuickCross catheter. The business units address needs in peripheral artery disease, company’s products are sold in With an increasing number such as critical limb ischemia and in-stent restenosis, over 65 countries and are used and in the lifetime management of cardiac implantable of homegrown product electronic device leads. But Donna Ford-Serbu, senior vice to treat arterial blockages approvals and commercial president of sales and marketing for Spectranetics’ lead in the heart and legs, and in management business, says the company always keeps successes, more companies the removal of pacemaker and the clinical need foremost. defibrillator leads. are demonstrating that it “We focus on attacking specific clinical needs rather than developing any one specific tool,” says Ford-Serbu. “Going is possible to successfully forward, we will continue our organic, navigate the corporate research-driven growth while also supplementing our portfolio through life cycle from concept to business development as we find commercialization without interesting innovations that fit with our clinical goals.” leaving the state. In support of this product growth strategy, Spectranetics last year A prominent example is TOLMAR, Inc., a fully integrated acquired AngioScore, Inc., a Fremont, pharmaceutical company headquartered in Fort Collins. California, based company that Although TOLMAR took its current form in 2007, its roots go manufactures and sells cardiovascular back to 1990, when its predecessor, Atrix Laboratories, was specialty balloons. The company also founded around a vision of developing and commercial- recently completed the acquisition of izing pharmaceutical products in dentistry. Within a few the Stellarex™ drug-coated balloon years, the company’s leaders began to appreciate that they angioplasty platform from Covidien. had developed something more fundamentally important Silvergate Pharmaceuticals, founded to the company’s long-term survival than any single dental in 2010 and based in Greenwood drug—their polymer-based, extended-release drug delivery Village, has married diversity with system Atrigel. focus by identifying opportunities within a niche market that has

2015-2016 BIOSCIENCE COLORADO 7 generally been overlooked by larger companies. As a “There are so many pediatric diseases that are important trained pharmacist with 30 years of diverse pharmaceutical from a patient point of view,” he says. “The eff ort is not easy, industry experience, President and CEO Frank Segrave had and there is a tremendous amount of work and diff icult noted a recurring unmet need for reformulating approved formulation science that goes into our products, but we see pharmaceuticals for pediatric populations. so many opportunities.” “By and large, big pharma companies have to concentrate Surefire Medical, based in Westminster, is another their eff orts developing molecules for mass markets,” says company whose platform technology holds the promise of diverse clinical application. The There is a strong need for drug formulations that company was formed meet the specific physiologic and developmental in 2009 by current CEO Silvergate Pharmaceuticals’ Jim Chomas, PhD, and needs of children. – FRANK SEGRAVE, PRESIDENT & CEO, co-founder Aravind first product, Epaned®, an SILVERGATE PHARMACEUTICALS enalapril maleate powder Arepally, MD, who together developed for oral solution, is targeted Segrave. “In hypertension, for example, they’re treating 30 the company’s Surefire Infusion System MT/LT. This to pediatric patients. million US adults with a drug like enalapril. The pediatric catheter-based system delivers therapeutic agents directly market is only about 100,000 kids, and that’s just too small to a desired treatment site within the peripheral vascular to be viable for them.” system—for example, the blood supply feeding a secondary breast-cancer metastasis within the liver—while As a result, he says, while pharmaceutical companies the catheter’s expandable tip blocks reverse blood flow evaluate drugs’ eff icacy and safety in children, the com- to improve therapeutic targeting. Again, although the mercialized drugs are oft en formulated as tablets and in company maintains a focus on its drug-delivery platform adult-sized doses. technology, the potential applications are broad and “Every day in children’s hospitals and in community include delivery of drugs, radiation therapy, embolics pharmacies across the country, there are kids who need and imaging agents for a wide range of disease states, a specific approved medication but are too young to just including cancer, obesity and many others. swallow a pill,” says Segrave. “There is a strong need for Founded in 2000, Boulder-based SomaLogic is yet another drug formulations that meet the specific physiologic and company developing a diverse product portfolio within a developmental needs of children.” focused platform. The company’s commercial products are The company’s first product, Epaned® (enalapril maleate based on two interrelated technologies: a novel, proprietary powder for oral solution), was approved in September 2013, class of protein-binding molecules called slow off -rate mod- and several more are in the development pipeline. Segrave ified aptamers, or SOMAmers, and a multiplex proteomic says that Silvergate Pharmaceuticals’ focus will remain on assay called SOMAscan. Together, these innovations enable the underserved pediatric market, but within a very diverse the simultaneous detection and quantification of more A Surefire Medical range of disease states. than a thousand distinct proteins in biological samples of cleanroom interest. Several of the individual SOMAmers are now being evaluated for potential as therapeutic agents. Byron Hewett joined SomaLogic as its CEO in 2013. Taking over for founding CEO, current chairman and Colorado bioscience icon Larry Gold, PhD, Hewett was charged with building out the commercial infrastructure of the company. He says that in principle each SOMAmer has commercial potential on its own and in combination with the others. “When I joined, Larry joked, ‘how oft en do you walk into a new company and have 1,129 products to take to market?’’’ laughs Hewett. “The reality is, that kind of product diversity is extraordinarily unusual, but we see 1,129 as just the beginning. We’re very excited about developing the many opportunities we have with this platform.” Funding strategies influence corporate destiny Although product diversity may prove to be an essential factor in a company’s commercial success, it is not enough to ensure independence. As Hewett explains, the pressures inherent to corporate financing and investment strategies can ultimately determine a company’s destiny. “We’ve seen that one reason bioscience companies start up in Colorado but can’t stay here long-term is that there is a

8 BIOSCIENCE COLORADO 2015-2016 fundamental mismatch between many venture capitalists’ Close community fosters success funding models and the healthcare product development While the long-term outlook for life cycle,” says Hewett. “With a five-year life on their funds, bioscience startups in Colorado VCs need an exit to recoup their investment and fulfill their continues to improve, the question obligations to their limited partners. But companies in this remains: what drives entrepreneurs space need four to 10 years to get a product to market. to put down roots here, when That can be problematic for healthcare companies who running a bioscience company rely on VC funding.” would arguably be so much easier on the West Coast or Eastern Chomas agrees. “As a startup, you have to raise financing, Seaboard? Intangibles like quality of course—since 2009 Surefire has raised $26 million—but it of life may always be a strong factor, has been a very tough environment. The product develop- but executives also cite a business ment cycle is slow for medical devices and other bioscience, culture that has more than made up and that can sometimes surprise investors who are used to for challenges they have faced. the rapid innovation in soft ware and technology fields.” “Of course we at Surefire Medical Hewett says that when Gold founded SomaLogic, his all love living in Colorado, but the previous company NeXstar Pharmaceuticals had recently closeness of the business community merged with Gilead Sciences. Gold was fortunate to here has had significant benefits as be able to draw on this personal experience and the well,” says Chomas. “I spent 15 years associated financial success to maintain close control over in the medical device industry in his vision for SomaLogic. Silicon Valley, and there are just so “Larry wasn’t very happy when they took the [NeXstar] many people there that you don’t feel science out to the West Coast,” says Hewett. “But when he like part of a tight-knit community founded SomaLogic, he was in a better position to fund the the way you do here. Here we meet regularly with the An illustration of a company himself. Of course he brought in strategic partners, universities, with the Colorado BioScience Association, and SOMAmer, or a slow but he specifically structured it so that he could maintain with state and local leaders to talk about our needs and off-rate modified control and independence, and pursue his vision without help them understand how we can all work together to get aptamer, which is a novel undue pressure to cut an exit deal other than what was in things done. I would never have thought to go to the state the best interests of the company and shareholders.” of California for those kinds of discussions, but here it’s proprietary class of possible, and that kind of networking is powerful.” protein-binding molecules TheThe productpr development cycle In fact, the strength of those relationships proved enough developed by SomaLogic. for Surefire Medical to move their manufacturing facilities is slowlow for medical devices and to Colorado from Miami Lakes, Florida. “While we were other bioscience, and that can headquartered here from the beginning, we had a partner in Miami Lakes with a clean room, machine shop, ISO sometimes surprise investors certification and a fully developed QC system to help us get who are used to the rapid our first product to market. And that area has a large concentration of companies in medical device manufacturing, innovation in software and technology fields.

This move turned out to be critical to the longevity of the company because, although the fundamental science patent / trademark / copyright behind the SOMAmer technology was sound, it was also so novel that the company had to spend nearly a decade of proud to protect R&D fine-tuning the technical aspects of the product. SomaLogic’s founder-financed strategy is somewhat bioscience innovations unusual, and indeed the other companies profiled here have grown mostly through internally generated capital or public markets, or cite unusually patient venture investors. Hewett is optimistic, however, that Gold’s serial entrepreneurship model will become more common as the local The Rocky Mountain Region’s oldest intellectual cluster matures. property firm and proud member of the Colorado “When entrepreneurs succeed, they want to see others do Bioscience Association. the same,” says Hewett. “As more entrepreneurs gain experience and have good exits, we may see more reinvestment Denver / Broomfield www.sheridanross.com 303.863.9700 into the local economy as they support and nurture the next generation of startups here in Colorado.”

2015-2016 BIOSCIENCE COLORADO 9 so it was helpful to be able to tap into that experience pool found the FDA here to be easy to work with—we can let initially.” Eventually, however, the State, county and city them know what’s coming up with our construction so they provided Surefire with enough incentives and support that can plan their workload, and just generally have a produc- it made sense to bring the manufacturing facilities and jobs tive running dialogue with them.” here to Colorado. According to Segrave, community support was also funda- Duncan, too, sees underappreciated value in the closeness mental to Silvergate’s success. “In just a few short years, we of the local bioscience community. He points out what he grew from a concept to an extremely small R&D enterprise sees as reduced competition for the services of the FDA’s to building an entire infrastructure including compliance, Denver District Off ice. finance, legal, administration, sales, commercialization and more. We essentially built a company from nothing, and “Once it’s ready, our new plant won’t be able to come online we had to figure out how to do everything from selecting a Inside Surefire Medical’s until we have our FDA inspection,” he says. “With such a building to finding an IT provider. We found a great support manufacturing facility. high density of companies in places like New Jersey, it can structure here in Colorado, with people willing to say be hard to get time and attention from the FDA there. We’ve ‘whatever you need, we’ll help you figure it out.’” Adds Hewett, “Larry came to Boulder 40 years ago as an assistant professor, and his commitment to Colorado is deep; this is home for him. But there’s a good business case for staying here, too. We have Nobel-prize winning scientists at the university, and they are the nucleus of a culture of invention and innovation. There is a lot of talent here, a lot of productivity here, and it makes sense to keep that in place and build up the commercial infrastructure around it. “We can successfully attract high-quality employees from outside Colorado to fill in any gaps in knowledge and experience,” Hewett continues. “But at least for us, it is important they live as well as work here. The opportunities are so vast, we need them to be in it up to their eyeballs with the rest of us.”

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10 BIOSCIENCE COLORADO 2015-2016 MERGING TECHNOLOGIESANDDISCIPLINES: Changing the Face of Healthcare

WRITTEN BY ADAM RUBENSTEIN

ack in 1965, Intel Corporation co-founder Gordon E. Moore put forth an observation that over the history of comput- ing hardware, chip performance would double every two years while costs will continue to come down. What has become known as Moore’s Law is, to this day, some 50 years later, gospel in the semiconductor industry. Moore’s Law has subsequently been adopted, in a generic sense, across a variety of industry sectors, and there is no doubt the Colorado bioscience ecosystem is the beneficiary of this logarithmic acceleration of technological innovation. The rapidly emerging field of HealthIT, leveraging elements such as cloud services and state-of-the-art chips, is the most obvious example of adhering to Moore’s Law. We find many examples of these cutting-edge Colorado companies integrating themselves with more traditional life science enterprises, e.g. in the context of companion diagnostic capabilities of traditional therapeutic development, accelerating the computational analytic power to deliver on the promise of health informatics, and pairing with the medical device field to off er breakthrough advances in the

2015-2016 BIOSCIENCE COLORADO 11 A cross-disciplinary, collaborative workforce Colorado bioscience is not only at the cutting edge when it comes to incorporating a diverse array of emerging technologies to drive new industries such as HealthIT. Our talented workforce is taking a similar cross-disciplinary approach towards uncovering new knowledge at the frontiers of science. This excellent work is transpiring at the BioFrontiers Institute at the University of Colorado, where researchers from the life sciences, physical sciences, computer science and engineering collaborate with each other and, when appropriate, also partner with industry to translate discovery into commercial applications. Credit: Patrick Campbell, University of Colorado

identification, prevention and treatment of disease. Let’s The BioFrontiers Institute maintains four University of Colorado visit with some of these Colorado bioscience pioneers cores of strength and expertise: BioFrontiers Institute and innovators. 1 » working with large data sets and genomics to Mobility has changed the way we live, and Denver-based surface diff icult-to-access information and model Professor Stephanie Bryant biological processes, sets up a bioreactor in her CirrusMD has taken advantage of this megatrend. The company is developing a mobile physician access solution 2 » using bioimaging to visualize, measure and under- lab with the help of graduate for large healthcare organizations by enabling convenient stand biological processes, access and timely medical care from local physicians in student, Stacey Skaalure. 3 » creating new therapeutic paradigms to support a way that is similar to how doctors address concerns for The bioreactor helps Bryant the development of new drugs, vaccines and other their friends and family—through text and video chat. The approaches to improve human health, and with her research on how HIPAA-compliant platform allows providers to off er secure implanted materials react to scheduled video visits, text messaging and image sharing 4 » studying regenerative biology to engineer new biological stressors. for patients over smartphones, tablets and computers. medical solutions. CirrusMD recently announced the launch of MyDigitalMD for members of Rocky Mountain Health Plans to access board certified physicians 365 days a year and, where Colorado’s own Thomas Cech, PhD, who was awarded the appropriate, avoid unnecessary trips to the emergency Nobel Prize for his discovery of the principle of RNA catalysis room, urgent care or doctor’s off ice. and is the recipient of the National Medal of Science and the Albert Lasker Basic Medical Research Award, directs the The New England Healthcare Institute estimates that $290 Institute. Immediately prior to assuming his leadership role billion in avoidable medical spending is generated an- at the BioFrontiers Institute, Cech spent nearly 10 years as nually by people not taking their medicine as prescribed. president of the Howard Hughes Medical Institute. Lack of medication adherence has serious ramifications for patients that results in higher health-related costs Not long ago, Nanoly Bioscience, a startup spinout for insurers and employers. Denver-based HealthIT company incubated within the BioFrontiers Institute, was company RxAssurance is focused on delivering solutions honored by the San Jose, California, based Tech Museum that address what happens when a patient leaves the of Innovation with its prestigious Tech Award. In addition, care of their provider by bringing together behavioral Nanoly cofounder and MD/PhD candidate Balaji Sridhar game theory, the psychology of online user interaction traveled to Silicon Valley to accept the Katherine M. Swan- and global availability to keep patients working towards son Young Innovator award for his work with the company. healthy habits. The RxAssurance Engagement Platform Nanoly was one of 10 teams from around the world selected is designed to eliminate unnecessary utilization through as winners. The company is developing a non-toxic polymer proactive interactions, return cost savings to providers and that can be blended with vaccines to prevent spoilage with- payors, and give patients tools to find long-term success out refrigeration, and then disassembles upon exposure to aft er their treatment. light so that the vaccine is ready for delivery.

12 BIOSCIENCE COLORADO 2015-2016 The collaborative nature of Colorado clinicians and post-operative surgical-site pain infusion market, and the EndoShape has received FDA researchers is further evidenced by some special work company has already successfully demonstrated that its 510(k) clearance for its first at the Children’s Hospital Colorado. There, the hospital’s technology works with the most commonly infused drugs, ® Heart Institute has teamed up with the department of such as saline, opioids, heparin, serum albumin, antibiot- product, Medusa Multicoil. bioengineering at the University of Colorado to study ics, insulin and epinephrine. three-dimensional imaging and heat-sensitive polymers, Boulder-based Biodesix was founded to apply the creating potential new medical devices to help treat principles of complex data analysis and mass congenital heart defects with minimal surgery. This 3D spectrometry to the discovery and develop- imaging creates a computer model and then constructs ment of improved multivariate tests that give a physical prototype allowing cardiologists to practice physicians better information to understand the procedures virtually or on the physical model. The work is patient and their disease. Call it personalized being lead by Robin Shandas, PhD, professor of pediatrics medicine. By better understanding the clinically and department chair. His seminal work on heat-sensitive meaningful information contained within each polymers has lead to the spinout startup company patient’s molecular profile, these tests function EndoShape, whose mission is to commercialize novel to improve diagnosis and therapeutic interven- medical devices based on proprietary polymer technology tion combined with the intention of leading and focusing on the coil embolization and occlusion to better outcomes. The company has com- market. The company has received FDA 510(k) clearance mercialized its first product, VeriStrat®, the first for sale of its first product, Medusa® Multicoil, in the US. serum proteomic test for advanced, non-small Data and its movement have dramatically evolved, thanks cell lung cancer patients that helps physicians in part to the web, Wi-Fi and Bluetooth technologies. determine if a patient should receive treatment Aurora-based Fluonic is a medical device startup pioneer- with Tarceva® (erlotinib). The company is not ing a new generation of infusion devices and information a one-product pony; there is also a platform in systems powered by a breakthrough microelectrome- place to enable a spectrum of tests. chanical systems (MEMS) flow sensor technology. The To enable the reliable use of mass spectrometry for the Fluonic product precisely monitors and controls drug flow analysis of patient samples, Biodesix developed ProTS®, to the patient, instantly detects problems and documents a technology platform that harnesses the power of mass compliance of patients. The flow sensor and regulator spec and provides an unparalleled ability to analyze and measure and control infusion rates with high accuracy compare complex data sets. ProTS enables the rapid and wirelessly communicate this information to HealthIT discovery and validation of diagnostic tests that answer systems. Fluonic’s initial opportunity is the reimbursed

The University of Colorado BioFrontiers Institute connects academia and industry, providing: • Access to expertise and equipment in eight core facilities, including imaging and Illumina sequencing • End-to-end experiment planning and design • Colocated lab space • Education for the next biotech leaders

Supporting Colorado’s

Biotech Entrepreneurs http://biofrontiers.colorado.edu/impact

2015-2016 BIOSCIENCE COLORADO 13 a wide range of clinical questions. The company has of illness or injury. Flashback, utilizing CipherSensor™ designed the tests to be non-invasive and require minimal technology, is building a set of algorithmic solutions to amounts of readily accessible biological fluids such as address these unmet needs. blood or serum. Wearable sensors are all the rage; just ask Tim Cook and Apple, right? Boulder-based Prima-Temp’s new technolo- By betterbett understanding the clinically gy provides precise and accurate core body temperature measurements. A reliable and convenient product allows mmeaningfulanin information contained within for continuous detection of subtle changes in temperature eachh patient’s molecular profile, these that is communicated directly to a smartphone. Their first product, Bloom, is a wearable sensor that benefits any tests function to improve diagnosis andnd woman who wants to eff ortlessly manage her fertility. therapeutic intervention combined withith Bloom is a self-inserted sensor that detects the subtle changes that occur before ovulation, and then sends an the intention of leading to better outcomes.comes. alert to a smartphone indicating when one is most fertile. Bloom pinpoints the window of fertility without having Littleton-based dbMEDx is a wireless medical device com- to actively engage in data collection. The company is pany that has developed the world’s smallest wireless 3D developing additional products for the obesity and weight ultrasound scan engine with an integrated image analysis. loss, sleep disorder and heat exhaustion markets. The BBS Revolution™ device wireless probe performs Gordon Moore must certainly have a smile on his face. images collection and analysis. The real-time, non-invasive Who would have envisioned 50 years ago that the nascent scanning technology combines the power and safety of semiconductor industry would have such a profound The BBS Revolution™ wireless ultrasound with sophisticated image processing electron- impact upon the world of bioscience? But that certainly probe device performs image ics and soft ware to provide simple and fully automated is the case. Whether a company is developing a wearable collection and analysis with diagnostic measurements. The BBS Revolution™ is an device that communicates its data to a variety of sources automated bladder volume measurement device, which to improve outcomes, or developing algorithms to surface real-time, non-invasive is an essential component of a comprehensive catheter scanning technology. potentially life-saving insights out of heaps of big data, associated urinary tract infection prevention program, or leveraging the web to connect cohorts more eff iciently and off ers the advantages of rapid and accurate bladder (which ultimately can save money for payors and providers), volume measurement, a wireless and lightweight probe, it is the convergence of cross-functional and disciplinary minimal user training and no required aiming. Recently, teams comprised of Colorado’s best and brightest minds dbMEDx announced that it received 510(k) clearance from that is enabling the flourishing HealthIT sector. the FDA to market this novel bladder scanner in the US, and sales are expected to begin in 2015. How big is big data? Boulder-based Flashback Technologies Howell might have something to say about that. The company Construction Building Collaboration Since 1935 has developed CipherSensor™, a computational engine that provides predictive decision support solutions to address data analysis needs. Flashback is focusing its eff orts on developing algorithms to transform minimally invasive patient monitoring to provide clinicians with new tools to improve outcomes and reduce healthcare costs. CipherSensor™ integrates techniques that include classification, regression, clustering, semi-supervised learning, reinforcement learning and active-ongoing learning, with feature extraction techniques derived from robotics and computer vision. This integration enables the development of models for estimation, prediction and control derived autonomously from extremely large (many terabyte) data sets. As data increases or changes, the product is able to eff iciently integrate this new knowledge into existing models without the need for relearning the model form scratch. Healthcare providers are typically unable to continuously monitor multiple vital signs from multiple patients 24 hours a day. Decisions regarding ongoing care and the application of life-saving interventions are historically made from qualitative “snap-shot” BioPharma Construction Experts observations, without the benefit of observing trends and the dynamic nature of the evolving pathophysiology 303-696-5800 www.howelldenver.com

14 BIOSCIENCE COLORADO 2015-2016 80% Startups at the University of Colorado OF STARTUPS ARE STILL OPERATING BIOTECH/ BIOSCIENCES 8989 96 HAVE OPERATIONS IN COLORADO SOFTWARE 1919 8 HAVE GONE PUBLIC PHYSICAL SCIENCES/ ENGINEERING 1818 19 HAVE BEEN ACQUIRED BY ENERGY/CLEANTECH PUBLIC COMPANIES 1515 FY2013-14 CU STARTUPS RAISED OVER Bioscience Innovation at the University of Colorado (all CU campuses) [email protected] | www.cu.edu/techtransfer $70M IN FOLLOW-ON FUNDING, CU Anschutz Medical Campus Research Resources – clinical trials, research (federal and state grants, venture financing administration and core lab facilities www.ucdenver.edu/anschutz/research and SBIR/STTR funding) CU-Boulder Office of Industry Collaboration –provides a key point of contact $6.2B for connecting with the services, expertise and capabilities of CU-Boulder. 303-492-0800 | [email protected] TOTAL FOLLOW-ON FUNDING. cu.edu/techtransfer 2015-2016 BIOSCIENCE COLORADO 15 Research, discovery and optimization DEVICE PHARMA Proof of concept Target validation Prototypes Lead optimization Risk analysis Candidate

Development University of Colorado Anschutz Medical Campus The concepts and subsequent multiple patents related to the genetically targeted use of Gencaro™ (bucindolol hydrochloride) were developed at Dr. Bristow’s lab at CU. DEVICE Design controls University of Colorado Hospital The hospital is one of the clinical investigative sites for the GENETIC-AF study (there will be approximately 60 in the US and Canada). Dr. Ryan Aleong is the Colorado site principal investigator.

Pyxant Labs CASE STUDY Pyxant is conducting some of the testing/ analysis for patients screened, and enrolled for the GENETIC-AF trial. ARCA biopharma, Inc. (Westminster) A public biopharma company conducting Phase 2B/3

adaptive design clinical trial (GENETIC-AF) evaluating Medtronic Gencaro™ as a genetically targeted potential treatment for Medtronic and ARCA have entered into a atrial fibrillation (AF). If successful, Gencaro™ would be the collaboration agreement to support the GENETIC-AF trial. first approved genetically targeted cardiovascular therapy.

Arrows point to involved Colorado entities

See the Directory on pages 40-62 for more information on companies and resources throughout Colorado. 16 BIOSCIENCE COLORADO 2015-2016 Connection Points in Colorado Colorado entities collaborate to move products through the development lifecycle.

Quest Research Quest Research provided prototyping. CASE STUDY Syncroness BioFusionary, Corp. (Wheat Ridge) Syncroness engineered certain BioFusionary develops products for tissue regeneration and elements of the product. repair to improve patient health, aesthetics and surgical procedures. Its first product, the Biofusionary Bebe™, is a non-invasive system that uses electromagnetic induction (EMI) to generate focused energy. It is cleared by the FDA and currently available for use by medical professionals.

Arrows point to involved Colorado entities (clinical and non-clinical)

PHARMA CSU School of Veterinary Medicine and Evergreen Research, Inc. Pre-Clinical Research Services, Inc. ERI is a partner for manufacturing These two entities conducted pre-clinical development, quality system CLINICAL: Trials Phase I, II, III animal studies. implementation and manufacture of BioFusionary’s flagship product, NON-CLINICAL: Drug metabolism, Biofusionary Bebe™. Pharmacokinetics, Testing, Drug scale-up

Manufacturing and commercialization DEVICE PHARMA Pre-production Manufacturing Production Compliance Next-generation Corporate

2015-2016 BIOSCIENCE COLORADO 17 Webb-Waring Biomedical Research Program

WRITTEN BY KRISTI ARELLANO

s the Boettcher Foundation enters Webb-Waring Foundation were entrusted to the Boettcher its sixth year of funding biomedical Foundation, whose history of philanthropic giving in research through its Webb-Waring Colorado stretches back to 1937. The Boettcher Foundation Biomedical Research Awards, the and the University of Colorado also committed to matching philanthropic foundation hopes that Webb-Waring monies to create a new and permanent the program can serve as an example funding stream for biomedical research in the state. to other states and funders seeking to “We had almost a blank slate and a creative opportunity to advance the biomedical sciences. address the problem of biomedical research funding,” said The Foundation, established in Denise Brown, founding executive director of the Colorado 1937 by Claude Boettcher and his BioScience Association and a bioscience industry consultant father, Charles, entered into a new who worked with the Boettcher Foundation to help establish arena when it expanded its funding the Webb-Waring awards. “The only string attached was that to include biomedical research. we do something in biomedical research.” Prior to that, the Boettcher Foundation, which Boettcher Foundation leaders approached the situation champions excellence across Colorado by investing in its systematically, conducting extensive research on the The award given to most talented citizens and high-potential organizations, biomedical research funding continuum. They met with Boettcher Investigators focused on scholarships, teacher training and capital and interviewed more than 30 stakeholders and experts grants to nonprofits. in Colorado’s bioscience community. At the conclusion The opportunity to create a new funding area focused on of those interviews, the Boettcher Foundation staff biomedical research came about when the Webb-Waring determined that its investment would be most eff ective if Foundation reached a pivotal crossroads. it focused on the gap faced by early career investigators. Early career investigators represent the future of the RecipientsR cipi of Webb-Waring Biomedical industry, engaging in exploratory research that will ultimately lead to the next generation of biomedical ReResearchsear Awards, who become known breakthroughs advancing human health. But this group of as Boettcher Investigators, are awardedarded scientists – oft en within a few years of their first academic appointments – is facing an increasingly challenging grants of $225,000, covering up to threethree environment for research funding. years of research. “Colorado can only be a leader in scientific innovation if its most dynamic scientific minds are supported at early Founded in 1924 by Dr. Gerald B. Webb and later directed stages in their work,” said Tim Schultz, president and by Dr. James J. Waring, the Webb-Waring Institute has executive director of the Boettcher Foundation. made significant contributions to the advancement of biomedical research, doing so largely by engaging in basic Recipients of Webb-Waring Biomedical Research Awards, and clinical research and training research scientists. A who become known as Boettcher Investigators, are separate but related entity known as the Webb-Waring awarded grants of $225,000, covering up to three years Foundation helped to support the Institute’s work. of research with a goal for them to establish themselves and become competitive for major awards from federal The Webb-Waring Institute became part of the Univer- agencies and other major sources. sity of Colorado in 2008. At that time, the assets of the

18 BIOSCIENCE COLORADO 2015-2016 The Boettcher Foundation has so far funded 35 early-career biomedical researchers in Colorado through its unique approach, which unites philanthropic funding with the state’s Boettcher Investigators academic research institutions. CLASS OF 2014 “Colorado has found a way to fit an important piece into the puzzle thanks to the partnership between philanthropy and academia,” said April Giles, president and CEO of the Colorado Roger Bannister, PhD BioScience Association. “We’re excited about this partnership and believe it can be replicat- University of Colorado, ed by those interested in similarly supporting biomedical research and innovation.” Anschutz Medical Campus A key component of the eff ort became the partnership between the Foundation and the state’s research institutions. While the Boettcher Foundation staff was experienced at managing both scholarships and capital grant programs, the level of expertise necessary to evaluate and select such complex scientific research became a critical issue. “It was important to us that we retain the merit and integrity of the peer-review process,” Subhajyoti De, PhD Schultz said. “By partnering with the institutions and asking them to oversee the selection University of Colorado, Anschutz Medical Campus process, we were able to ensure that the research proposals are evaluated by experts who truly understand the research process.” To ensure that it is funding the most promising researchers and solid science, the Foundation relies on committees of researchers from the state’s three largest research institutions to evaluate the proposals based on merit. The institutions then submit their top proposals Amy Dounay, PhD Colorado College BoettcherB ettc Foundation leaders say they hohopepe thet program can serve as a model for other states and regions seeking too advance biomedical research and supportpport Christopher Gentile, PhD early-career investigators. Colorado State University for funding from the Webb-Waring program. The state’s smaller research institutions follow a similar process, only their review committee is made up of a cross-section of scientists from the state’s larger institutions.

This approach takes advantage of the expertise that exists within Colorado’s research Loren Hough, PhD institutions and employs the time-honored peer review process. It also minimizes University of Colorado, Boulder the administrative resources required by the Foundation to support the Webb-Waring Biomedical Research Awards program. The diversity of the scientific disciplines and the complexity of biomedical research would make a single, centralized review process within the Foundation a diff icult, time-intensive and expensive proposition. With the Webb-Waring Biomedical Research Program now in its sixth year of awarding grants, the Boettcher Foundation has funded Investigators focused on a diverse range of research Kunhua Song, PhD University of Colorado, topics ranging from African Sleeping Sickness to pulmonary disease and Alzheimer’s. Anschutz Medical Campus Perhaps more important, all of the Boettcher Investigators who have completed their funding cycles have been awarded significant grants from the National Institutes of Health or other major research funders. And while the sample is still small, early data indicates that the average age for Boettcher Investigators to get their first major funding awards is lower than the national average. Rachel Zemans, MD Now that the program is proving successful, Boettcher Foundation leaders say they National Jewish Health hope the program can serve as a model for other states and regions seeking to advance biomedical research and support early-career investigators. Private funders, Boettcher leaders note, can have a significant impact on research funding even if they do not have the internal knowledge to select projects for funding. “Partnerships are a valuable tool when it comes to solving the significant challenges facing the scientific community,” Schultz said. “We believe the results of our partnership prove that it is possible for a broad range of interests to come together to create new and exciting ways to address these challenges.”

2015-2016 BIOSCIENCE COLORADO 19 he big idea, the novel finding, the unanticipated breakthrough: these are the hoped-for payoff s of public and private investment in bioscience research. In the next decade, discoveries made in laboratories across Colorado promise to bring us new ways to outsmart cancer, improve Strengthening the ecosystem – education, networks and advocacy the ease and safety of surgical procedures, regenerate An essential first resource for early-stage companies and damaged eye tissue, replace the function of missing limbs, their founders is the Colorado BioScience Association and diagnose and guide treatment decisions for a host of (CBSA). According to President and CEO April Giles, the complex heath conditions. association’s annual, two-day BioBoot Camp gives Scientists and engineers, however, are not typically trained would-be entrepreneurs a comprehensive overview of in entrepreneurship, and once the health implications the path through research and development, raising and potential commercial value of a discovery have been capital, setting up a company, regulatory compliance, appreciated, inventors may find themselves asking, “What clinical trials and commercialization. now?” Fortunately, Colorado boasts a robust network of “We help them evaluate the fundamental question, ‘Do I industry groups, foundations, government-sponsored really want to start a bioscience company?’” says Giles. programs, serial entrepreneurs, investors and service “We walk them through the immediate challenges they will providers that, together, make up a vibrant and supportive have to tackle as well as the longer-term questions they’ll ecosystem to foster the translation of research from the face as they grow.” bench to commercialization. CBSA and its subsidiary, the Colorado BioScience Institute, foster a host of formal and informal networking opportunities, continuing education and industry advocacy to support growing companies.

BRIDGING THE

FROM DISCOVERY TO COMMERCIAL SUCCESS

WRITTEN BY JEANNE MC ADARA-BERKOWITZ, PH D

20 BIOSCIENCE COLORADO 2015-2016 “Our programs and content are aimed at helping companies connect with the resources in our state that they will need as they navigate the path to commercialization,” says Giles. “We show them that they don’t have to be their own expert in those subsets of information. There are knowledgeable and experienced folks here willing to help them with that.” At the same time, CBSA continually engages in advocacy at the local, state and national levels to encourage legislative, tax and regulatory policies that are favorable to bioscience development. “We work with legislators to ensure we have the grant dollars, angel tax credits, business tax incentives, zoning and building codes, and other policies in place to make Colorado an attractive place to grow a company or invest in bioscience innovation,” she says. Closing early-stage funding gaps Obtaining adequate funding is a perennial challenge for bioscience companies in the long years before commercialization. “One problem is that over the last 10 years, we’ve seen a nationwide shift in investment strategies in bioscience,” says Ginny Orndorff , executive director of the Colorado Institute for Drug, Device and Diagnostic Development (CID4). “Venture capitalists and larger pharmaceutical or device companies used to pay for development of early-stage university or company technologies under research contracts or seed investments. Those investments have moved downstream, and university inventors and entrepreneurs Commercialization infrastructure with a good idea are finding they need to demonstrate Another key factor in the success of early-stage bioscience Dr. Dennis Roop, left, is companies is access to resources for engineering design, commercial milestones before they can interest corporate developing a cell-based therapy partners or raise significant venture capital.” process development, clinical-grade manufacturing, regulatory aff airs and quality systems. Providing these capabilities for Adam Klafter, right, who At the earliest stages, grants from Colorado’s Off ice of Eco- in-house can be out of reach for many startups. has a genetic condition called nomic Development and International Trade (OEDIT) have helped supply needed funds to help startups demonstrate “Here in Colorado we are fortunate to have an infrastructure Epidermolytic Ichthyosis. the commercial feasibility of their technology. For carefully rich in design, process and contract manufacturing exper- Dr. Roop has corrected Adam’s selected companies graduating out of these programs, CID4 tise to support commercialization in all bioscience sectors, disease in vitro and will use the including medical device, biotechnology and diagnostics,” has been able to provide investments and mentoring, as Gates Biomanufacturing Facility well as assistance in obtaining additional grant funding, to says Giles. She cites contract pharmaceutical manufactur- help bridge the remaining funding gap until they can attract ing and discovery organizations such as KBI Biopharma, to expand Adam’s healthy cells angel investment, venture capitalists or strategic partners. CordenPharma and Array Biopharma in Boulder, as well for future transplantation. as medical device manufacturing operations such as CEA Medical Manufacturing (Colorado Springs), Mountainside WeW walkwa them through the Medical (Louisville) and Evergreen Research (Golden). imimmediatemed challenges they One of the newest additions to Colorado’s biotechnology commercialization infrastructure is the new, 14,000-square- will have to tackle as well as foot Gates Biomanufacturing Facility, part of the Gates the longer-term questionsons Center for Regenerative Medicine at the University Of Col- orado Anschutz Medical Campus. The Center’s capabilities they’ll face as they grow.w. will be dedicated to helping investigators and early-stage – APRIL GILES, CEO, CBSA ventures develop and manufacture clinical-grade biologic products and cell therapies for use in clinical trials. Orndorff points out that the eff orts of CID4 and similar “We have been fortunate to partner with the University of groups help Colorado recapture the downstream Colorado, Anschutz Medical Campus, the University of benefits from federal research dollars coming into the Colorado Medical School, Children’s Hospital Colorado, the state. “The government spends more than $600 million University of Colorado hospital system, the Gates Frontiers annually to support academic life-sciences research in Fund, and funders from the private sector to help develop Colorado,” says Orndorff . “If the discoveries coming out this academic GMP facility,“ says Dennis Roop, PhD, Director of that research stay in Colorado, that benefits our state’s of the Gates Stem Cell Center. citizens and the economy.”

2015-2016 BIOSCIENCE COLORADO 21 through a gift from the Blackstone Charitable Foundation to the Silicon Flatirons Initiative at the University of Colorado School of Law. “Our goal is to connect serially successful entrepreneurs from various industry silos in Colorado, and to leverage that collaborative network to spur the State’s most promising private companies, or gazelles, to become breakout winners,” says Holston. Holston says that BEN’s gazelles come not only from the health science industry, but also from other promising segments including energy, aerospace, natural products and technology. Regardless of focus, they share characteristics that, given the right resources and guidance, could enable them to rapidly scale up to very large economic profiles and outcomes. Roop says that the Gates Center will operate as a cost-neutral “We provide connections, mentorship, introductions to core facility and, aft er a phased rollout, will provide services capital sources, and other resources necessary to ensure to academic, non-profit and for-profit clients. that these gazelles accelerate in Colorado,” says Holston. “With a facility like this, the University is in a better position to Asked why such a resource is needed here, Holston points recruit outstanding young scientists who are committed to out that Colorado is rich in startup culture, but that there is getting their technologies into the clinic,” says Tim Gardner, currently not enough focus on overcoming the challenges the Center’s Director of Finance. “Our hospitals will be able that come as companies begin to scale up. He says that bio- to off er the latest, most cutting-edge clinical trials to their science companies at this stage are particularly vulnerable patients. And all of that will help keep those breakthroughs to being acquired by out-of-state interests, and taking their here in Colorado as they wind through the clinical develop- technology and jobs with them when they leave. ment stage and into commercialization. We think this Center provides a critical enabling capacity that will help to create an outstanding bioscience manufacturing center in this region.” HolstonHo sto predicts that the Fueling acceleration tigtight-knit,ht-kn even altruistic Even mid-size companies that have survived the gauntlet of early funding and product development challenges face business culture in Coloradora new hurdles as they begin building out and scaling up their will be integral to the nextext commercial enterprises. The Blackstone Entrepreneurs Network (BEN) of Colorado, based in Boulder, was founded decade’s success stories.s. in 2014 to assist promising young companies through this stage of their growth. “If we can help more companies win here and stay here, According to Executive Director J.B. Holston, BEN is a there will be a lot of dividends,” he says. Holston envisions non-profit corporate foundation that was initially funded a virtuous cycle of new growth from corporate spin-off s, reinvestment from local entrepreneurs who have achieved success, and a growing pool of experienced management talent. “Capital investments may increase as investors looking for big returns see that they can invest here in Colorado and not have to exit so soon.” Holston predicts that the tight-knit, even altruistic business culture in Colorado will be integral to the next decade’s success stories. “Colorado is so collaborative,” he says. “It’s not as trans- actional as other areas. People here want to make this EĂƟŽŶĂůZĞƐŽƵƌĐĞĨŽƌůŝŶŝĐĂůZĞƐĞĂƌĐŚ ecosystem work and care about shared work in an agile, ĂŶĚ fleet, ‘pay-it-forward’ kind of way.’” zŽƵƌWĂƌƚŶĞƌŝŶWĞƌƐŽŶĂůŝǌĞĚDĞĚŝĐŝŶĞ Holston says that culture is a big draw. “It’s part of why ĂŶĚ,ĞĂůƚŚĐĂƌĞ/ŶŶŽǀĂƟŽŶ people come here. They want to start something up and get plugged in without having to break down those barriers based on who you are and who you know.” ǁǁǁ͘ĐŚŝƌĞƐĞĂƌĐŚ͘ŽƌŐ

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2015-2016 BIOSCIENCE COLORADO 23 WRITTEN BY KIM JACKSON

24 BIOSCIENCE COLORADO 2015-2016 The Biotechnology Industry Organization reported last June that in 2012: ioscience is big business. U.S. bioscience companies provided: The Biotechnology Industry Organization (BIO) reported last June that in 2012 (the most recent year reported), 1.62 MILLION across 73,000 US bioscience companies provided 1.62 million jobs JOBS BUSINESSES nationwide across 73,000 individual businesses—and supported an additional 6.24 million indirect jobs throughout the rest of the economy. Of that, Colorado bioscience companies provided: Colorado’s bioscience industry that same year provided 28,510 jobs, and in the last five years, venture capital invest- 28,510 and had $1.1 BILLION ments in Colorado bioscience companies totaled $1.1 billion. JOBS IN VC INVESTMENTS (in the last five years) That’s good news for Colorado. Thanks to our strong collaboration between infrastructure—including universities, Originally housed in the original Army hospital on the non-profit organizations and commercial incubators—and campus, the FIC has grown to three buildings of its own, the entrepreneurs and founders who want to commercial- each with its own purpose—all just across the street from ize their innovations, Colorado is popping up more oft en the University of Colorado Anschutz Medical Campus with on the national radar as a hot bioscience cluster. the clinical expertise and hospital systems to partner on From Colorado Springs to Fort Collins, Aurora to Boulder, research and development while also providing access to several resources and incentives in the state help a large patient population for clinical trials. entrepreneurs refine The Bioscience bioscience innovations, Park Center and then develop and grow WeWe wantwa to work together so we Bioscience East boast their businesses. cacann mmake discoveries relevanta 85,000 square feet of Fast-track startups get to society and bring companiespanies incubator space for Silicon Valley guidance both early-stage and in Colorado Springs closer to our community. established bioscience The Colorado Springs companies. They Technology Incubator mentors fast-track startups, and currently house 48 companies and include ample lab and off ers guidance on everything from managing business executive off ice space, and shared services. The Bioscience and product development to finding investors. Park Center also houses 30,000 square feet of build-to-suit accelerator space for growing, more mature companies. CEO Ric Denton has found that what young companies need most is working out their go-to-market strategies. The 112,000-square-foot Bioscience 2 Building opened in A Silicon Valley biotech entrepreneur with university April with the University of Colorado’s innovative bioen- teaching experience, Denton explained that the added gineering program located on the first floor and the top value of the non-profit organization is in its mentors. “We have people with deep backgrounds as entrepreneurs.” The 22,000-square-foot facility houses off ice space for startups that meet the incubator’s criteria: A viable business model for potentially scalable companies with strong management teams (or the potential to build them out) with an opportunity for future high growth. Last year, the incubator partnered with the Air Force Academy to help in technology transfer activities that directly link to the Academy’s $64 million research program. This partnership supports new business in the region and Colorado. Bioscience companies percolate in Fitzsimons’ incubator In Aurora, the 578-acre Fitzsimons Innovation Campus (FIC) has been incubating bioscience startups since 1998.

2015-2016 BIOSCIENCE COLORADO 25 The building itself, where everyone must pass through a main corridor to get from one place to another, is designed to encourage hallway conversations. Hallway whiteboards encourage spontaneous idea sessions and every week, a company or academic lab hosts a “cookie hour” for anyone in the building. “We’re interested in seeing bioscience grow in Colorado,” observed Jana Watson-Capps, associate director of the BioFrontiers Institute, “and we’re coming from an academic position. We want to work together so we can make discoveries relevant to society and bring companies closer to our community.” Research Innovation Center fosters life science R&D in Fort Collins Located in Colorado State University’s Judson Harper two floors built to house growing bioscience companies. Research Complex in Fort Collins, the Research Innova- The Research Innovation “This new building off ers students the chance to rub tion Center (RIC) serves as a vehicle to perform collabo- Center (RIC) on Colorado shoulders with commercial entities,” states Vicki Jenings, rative translational-stage research with the campus’ life State University’s campus. director of business relations for Fitzsimons Redevelop- sciences community. ment Authority. “We constantly look for collaboration The Judson Harper Research Complex also includes the opportunities to bring university people together with Infectious Disease Research Center, Rocky Mountain commercial people.” Regional Biocontainment Lab, Arthropod-borne and In Boulder, academic departments co-locate Infectious Diseases Laboratory, the Centers for Disease for meaningful collaboration Control and the USDA-APHIS Wildlife Research Center. The University of Colorado BioFrontiers Institute in The RIC serves as a life science accelerator by helping Boulder co-locates faculty members from 10 academic startup and established companies. With academic departments with students and companies through faculty on the first floor and the incubator housing 10 technology transfer, industrial partnerships, internships companies on the top floor of the building, companies and mentoring in the Jennie Smoly Caruthers Biotech- are embedded in a strong academic environment, with nology Building on the university’s east campus. access to many subject matter experts. Inside the 300,000-square-foot building, faculty members Additionally, companies on and off campus have access collaborate with industry to fully equipped, flexible BSL-2 labs and BSL-3 facilities, to see their discoveries while incubated companies also have access to CSU’s become relevant. Students state-of-the-art vivarium and laboratory animal services. gain real-world experience Fort Collins-based Innosphere and the chance to work with helps startups raise capital companies as they expand. A partner to the Research Innovation Center in Fort Collins, And young companies use the Innosphere is a nonprofit incubator that was formed flexible lab space, core to accelerate the success of high-impact scientific and facilities, a stimulating technology companies, and to promote the development research environment and of a regional entrepreneurial ecosystem in Colorado. an educated workforce. Headquartered in a 30,000-square-foot innovation center Demand for space in the in Fort Collins, Innosphere also has satellite locations building has outpaced to better serve entrepreneurs. These locations include supply. Yet many small com- Colorado State University, INDUSTRY Denver and the panies use the core facilities’ Colorado Center for Renewable Energy Economic services, equipment and Development in Golden (which is co-located with the expertise on a fee-for-service Pharmaceutical Research & Manufacturers of America National Renewable Energy Laboratory). Disease is our enemy. Working to save lives is our job. basis. Facilities are also available for more interac- Its incubation program currently helps 39 entrepreneur- tive collaboration. ial startups—including 11 bioscience companies—raise

26 BIOSCIENCE COLORADO 2015-2016 capital, assemble solid management teams, develop partners, and connect with academic and governmental institutions and develop a network of advisors. Stride district will help innovators in healthcare industry Based in downtown Denver, Stride expects to be a world-class health technology campus. When complete later this year, the campus will be dedicated to enabling healthcare innovation by focusing on digital health, wearable tech, “smart” device and enterprise platforms. The unique innovation district will be home to corner- stone Fortune 500 tenants, several mid-sized users, emerging businesses, an incubator, venture capital, and an innovation and 3D printing/idea lab. Bioscience is indeed big business. And thanks to the rich resources available in Colorado, entrepreneurs and fast-growing companies are getting the help they need to develop, finance and commercialize their innovations.

Kim Jackson is a consultant for Green Tape LLC (greentapellc.com), which helps organizations win government R&D Innosphere offers companies access to a broad network funding, then administers awards so the small R&D firm can of state-of-the-art facilities, including a 30,000-square-foot innovation stay focused on its innovations. center of office and wet lab space at the Fort Collins headquarters.

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For more information: www.biopharminsight.com [email protected] T +1 781 762-9450

2015-2016 BIOSCIENCE COLORADO 27 Spinal (1) OB-GYN (1) Imaging (1) Vascular (1) Vascular Dental (2) Dental Wound (2) Respiratory (1) Respiratory Microbiology (1) Microbiology Contraception (1) Contraception Drug Discovery (1) Immunology (2) Pain Treatment (2) Treatment Pain Clinical Toxicology (2) Toxicology Clinical

MED TECH investigational and approved

By medical specialty

INTER 190190 TOTALTOTAL CONNECTED DEVICESDEVIC E S Drugs, devices and therapies in Colorado Diagnostics (26) Cardiovascular (23) Cardiovascular Hematology (22) Hematology (22) and Plastic Surgery General General Hospital (18) Hospital General Clinical ChemistryClinical (17) Gastroenterology/Urology (11) Gastroenterology/Urology Orthopedic (8) Drug Delivery (8) Neurology (4) Neurology Ophthalmic (4) Ear, Nose, Throat (3) Nose, Throat Ear, Radiology (3) Radiology Cancer (2) Cancer STUDIES DRUGS MED DEVICE performed by CO HQ companies from CO HQ companies investigational and approved

223 TOTAL INVESTIGATIONAL

Studies Completed (121) Discovery (51) 630 TOTAL Studies In Progress (35) Pre-Clinical (75) APPROVED Studies Recruiting (90) Phase I (37) Phase II (38) Phase III (12) Top five companies ranked in order Approved (10) of the most investigational devices 268 TOTAL* STUDIES Spectranetics Corp. 18 Colorado Springs 223 TOTAL Corgenix Medical Corp. 14 Broomfield DRUGS nSpire Health 13 Longmont By medical specialty: Baxa Corp (Now Baxter) 12 Englewood Cancer ()(73) Allosource 9 Centennial By medical specialty: Cardiovascular ((28) Cancer ()(76) Central Nervous Systemy() (41) Top six companies ranked in order Cardiovascular ((20) Dermatology (1) of the most approved devices Central Nervous System (9) Eyey and Ear (6) Dermatology (1) GGastrointestinal (16) Spectranetics Corp. 138 Colorado Springs Diagnostic/Imagingg Agents/Delivery (8) ValleyLab 104 Boulder Genitourinary (73) Fischer Medical Tech. 73 Broomfield Eye and Ear (1) HIV Infections (73) Unipath, LLC 73 Denver Gastrointestinal (1) Lanx, Inc. 36 Broomfield Hematologyg (73) Terumo BCT 35 Lakewood Genitourinary (0) Hormonal Systemsy() (73) HIV Infections (3) Immune System (73) Hematology (7) Infectious Diseases (73) Hormonal Systems (14) Musculoskeletal ((73) TOTAL FILINGS Immune Systemy( (23) Nephrologyp (73) Infectious Diseases ()(34) Pain ()(73) 510k (3) Musculoskeletal (13) 14 TOTAL Respiratorypy (73) PMA (11) FILINGS Pain (4)

Respiratoryp (9) * Total amounts are not the sum of studies broken down by therapeutic, as some studies may be listed under one or more therapeutic area.

Information provided by BioPharm Insight COLORADO BY THE NUMBERS

2014 FINANCINGS

Company Public Ticker Close Date City $USD M Type of Event/Round Investor/Partner Industry Type 2B Technologies, Inc. 5/16/14 Boulder 0.15 Grant Funding NIH Diagnostics Acess Sensor Technologies, Inc. 6/30/14 Fort Collins 0.15 Grant Funding NIH Diagnostics Advanced RNA Technologies, LLC 8/19/14 Boulder 0.72 Grant Funding NIH Pharmaceutical Advanced RNA Technologies, LLC 9/8/14 Boulder 0.19 Grant Funding NIH Pharmaceutical Ampio Pharmaceuticals, Inc. AMPE 3/5/14 Englewood 68.0 IPOs/Off erings Pharmaceutical Ampio Pharmaceuticals, Inc. AMPE 2/27/14 Englewood 55.0 IPOs/Off erings Pharmaceutical Ampio Pharmaceuticals, Inc. AMPE 2/24/14 Englewood Undisclosed IPOs/Off erings Pharmaceutical Ampio Pharmaceuticals, Inc. AMPE 12/13/13 Englewood Undisclosed Alliances Vyrix Pharmaceuticals Pharmaceutical ARCA Biopharma, Inc. ABIO 2/4/14 Westminster 9.0 IPOs/Off erings Pharmaceutical ARCA Biopharma, Inc. ABIO 2/3/14 Westminster Undisclosed IPOs/Off erings Pharmaceutical Biodesix, Inc. 4/10/14 Broomfield Undisclosed Alliances AVEO Oncology Diagnostics Biodesix, Inc. 1/13/14 Broomfield 6.1 Venture Financing/Series E Diagnostics Biodesix, Inc. 1/10/14 Broomfield 20.0 Financing Agreements Capital Royalty Partners LP Diagnostics Boulder Biotechnology, Inc. 2/27/14 Boulder 1.0 Grant Funding NIH Biotechnology Boulder Biotechnology, Inc. 4/22/14 Boulder 0.73 Grant Funding NIH Biotechnology Clovis Oncology Inc CLVS 9/9/14 Boulder 37.5 IPOs/Off erings Biotechnology Clovis Oncology Inc CLVS 9/3/14 Boulder 250.0 Stock Off ering Biotechnology Clovis Oncology Inc CLVS 9/3/14 Boulder 200.0 Stock Off ering Biotechnology Clovis Oncology Inc CLVS 4/3/14 Boulder Undisclosed Alliances Foundation Medicine Biotechnology Colorado Photopolymer Solutions, LLC 8/11/14 Boulder 0.15 Grant Funding NIH Pharmaceutical Corgenix Medical Corporation CONX 6/5/14 Broomfield 0.99 Grant Funding NIH Medical Device Corgenix Medical Corporation CONX 6/26/14 Broomfield 2.9 Grant Funding NIH Diagnostics Corgenix Medical Corporation CONX 12/24/14 Broomfield 0.82 Grant Funding Bill & Melinda Gates Foundation and Diagnostics Paul G. Allen Family Foundation Crestone, Inc. 7/3/14 Boulder 1.0 Grant Funding NIH Biotechnology Crestone, Inc. 7/25/14 Boulder 0.15 Grant Funding NIH Biotechnology dBMEDx 9/10/14 Littleton 0.0075 Award CBSA Medical Device Fluonic, Inc. 9/18/14 Boulder 0.15 Grant Funding NIH Medical Device GlobeImmune, Inc. GBIM 7/28/14 Louisville 1.0 Grant Funding NIH Biotechnology Globeimmune, Inc. 7/8/14 Louisville 17.25 IPOs/Off erings Biotechnology Globeimmune, Inc. 7/1/14 Louisville 15.0 IPOs/Off erings Biotechnology Globeimmune, Inc. 4/29/14 Louisville Undisclosed IPOs/Off erings Biotechnology InDevR, Inc. 4/30/14 Boulder 0.3 Grant Funding NIH Diagnostics InDevR, Inc. 7/22/14 Boulder 0.96 Grant Funding NIH Diagnostics InDevR, Inc. 9/15/14 Boulder 14.7 Contract HHS/BARDA Diagnostics Invisible Hand Enterprises, Inc. 7/18/14 Westminster 0.47 Grant Funding NIH Medical Device Kestrel Labs, Inc. 4/11/14 Boulder 0.65 Grant Funding NIH Medical Device

30 BIOSCIENCE COLORADO 2015-2016 2014 FINANCINGS continued

Company Public Ticker Close Date City $USD M Type of Event/Round Investor/Partner Industry Type Lohocla Research Corporation 6/25/14 Aurora 0.16 Grant Funding NIH Biotechnology MBC Research, Inc. 9/16/14 Aurora 0.1 Grant Funding NIH Pharmaceutical MBio Diagnostics, Inc. 7/2/14 Boulder 0.7 Grant Funding NIH Diagnostics MBio Diagnostics, Inc. 7/2/14 Boulder 0.99 Grant Funding NIH Diagnostics Meadowlark Optics, Inc. 9/4/14 Frederick 0.27 Grant Funding NIH Photonics MenoGeniX, Inc. 7/30/14 Aurora Undisclosed Private Financing Biotech/Pharma Miragen Therapeutics, Inc. 6/26/14 Boulder 7.0 Financing Agreements Servier Biotechnology MusclePharm Corp. MSLP 9/17/14 Denver 8.0 Financing Agreements ANB Bank Pharmaceutical MusclePharm Corp. MSLP 5/13/14 Denver Undisclosed Financing Agreements Pharmaceutical MusclePharm Corp. MSLP 1/6/14 Denver Undisclosed Mergers and Acquisitions BioZone Pharmaceuticals, Inc Pharmaceutical Nivalis Therapeutics, Inc. 11/19/14 Boulder 30.0 Venture Financing Wellington Management; RA Pharmaceutical Capital Management, LLC; Jennison Associates LLC; Rock Springs Capital Management LP; Sabby Management LLC Nivalis Therapeutics, Inc. 11/12/14 Boulder Undisclosed Corporate Event Pharmaceutical Omni Bio Pharmaceutical, Inc. OMBP 4/29/14 Fort Collins Undisclosed Alliances Gallus BioPharmaceuticals, LLC Pharmaceutical Omni Bio Pharmaceutical, Inc. OMBP 4/24/14 Fort Collins 3.0 Financing Agreements Bohemian Investments LLC Pharmaceutical Op-t-mune, Inc.OP 6/11/14 Denver 0.21 Grant Funding NIH Diagnostics QuSpin, Inc. 1/13/14 Louisville 0.76 Grant Funding NIH Diagnostics QuSpin, Inc. 8/22/14 Louisville 0.5 Grant Funding NIH Diagnostics QuSpin, Inc. 12/19/14 Louisville 0.73 Grant Funding NIH Diagnostics Sapphire Technologies 10/7/14 Denver 0.2 Grant Funding CID4 Dental Sharklet Technologies, Inc. 7/11/14 Aurora 0.68 Grant Funding NIH Medical Device Sharklet Technologies, Inc. 9/5/14 Aurora 0.025 Grant Funding NIH Medical Device Sharklet Technologies, Inc. 9/18/14 Aurora 0.22 Grant Funding NIH Medical Device Siva Therapeutics 3/18/14 Boulder Undisclosed Alliances SomaLogic, Inc. Medical Device Siva Therapeutics 1/23/14 Boulder Undisclosed Alliances Plexxikon Inc. Medical Device SmartMove, Inc. 4/25/14 Fort Collins 0.007 Grant Funding NIH Medical Device SomaLogic, Inc. 10/20/14 Boulder Undisclosed Research Agreement Novartis Diagnostics Taiga Biotechnologies, Inc. 9/5/14 Aurora 0.19 Grant Funding NIH Biotechnology Taiga Biotechnologies, Inc. 9/12/14 Aurora 0.18 Grant Funding NIH Biotechnology TDA Research, Inc. 7/30/14 Wheat Ridge 0.18 Grant Funding NIH Chemical TDA Research, Inc. 9/12/14 Wheat Ridge 0.15 Grant Funding NIH Diagnostics Ventria Bioscience 4/3/14 Fort Collins 0.26 Grant Funding NIH Biotechnology Ventria Bioscience 12/24/14 Fort Collins 0.31 Grant Funding NIH Biotechnology

2015-2016 BIOSCIENCE COLORADO 31 2013 FINANCINGS

Company Public Ticker Close Date City $ USD M Type of Event/Round Investor/Partner Industry Type AktiVax, Inc. 2/25/13 Aurora 0.2 Venture Financing CID4 Medical Device Aktiv-Dry, LLC 6/1/13 Boulder 0.4 Grant Funding NIH Biotech Ampio Pharmaceuticals, Inc. AMPE 9/26/13 Greenwood Village 25.0 Stock Off ering Pharmaceutical Arca Biopharma Inc ABIO 5/30/13 Broomfield 20.0 Stock Off ering Pharmaceutical Array BioPharma Inc. ARRY 7/29/13 Boulder Undisclosed Alliances Global Blood Thera- Biotech peutics BaroFold, Inc 6/1/13 Aurora 0.1 Grant Funding BDEGP Biotech Biodesix, Inc. 4/11/13 Boulder Undisclosed Alliances Bruker Daltonics Diagnostics Biodesix, Inc. 4/12/13 Boulder 8.8 Stock Off ering/ Series D Diagnostics Biodesix, Inc. 12/2/13 Boulder 8.3 Preferred Equity Diagnostics Financing/ Series E BiOptix Diagnostics Inc. 3/14/13 Boulder 5.0 Venture Financing Boulder Ventures Ltd. Diagnostics Bolder Biotechnology, Inc. 3/8/13 Boulder 1.0 Grant Funding NIH Biotech Bolder Biotechnology, Inc. 5/15/13 Boulder 0.5 Grant Funding NIH Biotech Corgenix Medical Corporation CONX 5/22/13 Broomfield Undisclosed Alliances Eli Lilly Diagnostics Corgenix Medical Corporation CONX 7/11/13 Broomfield Undisclosed Alliances EDP Biotech Diagnostics Corgenix Medical Corporation CONX 9/4/13 Broomfield 1.5 Financing Agreements Bank of the West Diagnostics/Therapeutics Corgenix Medical Corporation CONX 10/28/13 Broomfield Undisclosed Alliances Health Diagnostic Diagnostics Laboratory, Inc. ( Corgenix Medical Corporation CONX 11/18/13 Broomfield Undisclosed Alliances Zalgen Labs Diagnostics Crestone, Inc 7/1/13 Aurora 1.0 Grant Funding NIH Biotech dbMEDx 12/20/13 Littleton 0.2 Grant Funding AI Medical Device dBMEDx™, Inc. 4/4/13 Littleton 1.1 Stock Off ering Medical Device Entero Track 6/1/13 Centennial 0.3 Grant Funding BDEGP Diagnostics/Therapeutics FitBionic 8/8/13 Boulder 2.2 Venture Financing High Country Venture Medical Device Flashback 1/30/13 Boulder 0.8 Angel Angel investment group Medical Device Soft ware Flashback 3/26/13 Boulder 0.1 Grant Funding STTR Ph III Medical Device Soft ware Globeimmune, Inc. 9/4/13 Louisville 4.0 Grant Funding NIH Biotech Globeimmune, Inc. 10/31/13 Louisville 60.0 Stock Off ering Biotech InDevr, Inc. 2/1/13 Boulder 1.0 Grant Funding NIH Diagnostics/Therapeutics Lanx, Inc. 5/13/13 Broomfield 15.0 Venture Financing/ Credit Suisse Asset Medical Device Series C Management Lohocla Research Corporation 7/15/13 Aurora 0.2 Grant Funding NIH Biotech MBC Research Inc 6/1/13 Aurora 0.2 Grant Funding NIH Biotech MBC Research Inc 9/26/13 Aurora 0.8 Grant Funding NIH Biotech MBio Diagnostics, Inc. 3/1/13 Boulder 0.8 Grant Funding NIH Diagnostics/Therapeutics MBio Diagnostics, Inc. 4/24/13 Boulder Undisclosed Alliances Foundation for Innovative Diagnostics/Therapeutics New Diagnostics (FIND) MBio Diagnostics, Inc. 7/8/13 Boulder 0.7 Grant Funding NIH Diagnostics/Therapeutics MBio Diagnostics, Inc. 8/2/13 Boulder 0.9 Grant Funding NIH Diagnostics/Therapeutics Membrane Protective Technologies 12/20/13 Fort Collins 0.1 Grant Funding AI Biotech Inc. (MPTI) Microbiome Therapeutics 12/16/13 Broomfield 1.3 Financing Agreements Biotech nSpire Health 3/21/13 Longmont Undisclosed Alliances 4sigma GmbH Diagnostics OptiEnz Sensors, LLC 9/10/13 Fort Collins Undisclosed Grant Funding NSF SBIR Diagnostics Quspin 9/24/13 Westminster 0.6 Grant Funding NIH Medical Device Shape Ophthalmics, LLC 6/17/13 Denver Undisclosed Alliances OASIS Medical Inc. Medical Device Sharklet Technologies, Inc. 7/18/13 Aurora 0.2 Grant Funding NIH Medical Device Sharklet Technologies, Inc. 9/17/13 Aurora 1.1 Grant Funding NIH Medical Device SixOne Solutions 6/1/13 Aurora 0.1 Grant Funding BDEGP Biotech SixOne Solutions 7/17/13 Aurora 0.3 Grant Funding NIH Biotech SmartMove 5/24/13 Fort Collins 0.4 Grant Funding NIH Biotech SmartMove 6/1/13 Fort Collins 0.2 Grant Funding BDEGP Biotech Somalogic Inc 8/12/13 Boulder Undisclosed Alliances Agilent Technologies Inc. Diagnostics Somalogic Inc 8/21/13 Boulder 10.0 Venture Financing Medical Device Surefire Medical 9/23/13 Westminster 16.4 Venture Financing Medical Device Surefire Medical 11/7/13 Westminster 18.2 Venture Financing Partisan Management Medical Device Group SuviCa, Inc. 9/12/13 Boulder 0.2 Grant Funding NIH Biotech Tissue Fusion 6/1/13 Colorado Springs 0.1 Grant Funding BDEGP Medical Device Ventria Bioscience 2/15/13 Fort Collins 0.2 Grant Funding NIH Biotech Ventria Bioscience 6/1/13 Fort Collins 0.8 Grant Funding NIH Biotech Ventria Bioscience 9/20/13 Fort Collins 0.2 Grant Funding NIH Biotech VetDC, Inc 12/20/13 Fort Collins 0.2 Grant Funding AI Biotech VetDC, Inc 5/1/13 Fort Collins 1.3 Venture Financing Angel Investors Biotech VetDC, Inc 11/1/13 Fort Collins 1.1 Venture Financing Angel Investors Biotech ViroCyt, LLC 1/15/13 Denver Undisclosed Venture Financing High Country Venture Diagnostics/Therapeutics Xalud Therapeutics, Inc. 2/8/13 Boulder 0.7 Grant Funding SBIR Biotech Xalud Therapeutics, Inc. 6/1/13 Boulder 0.2 Grant Funding BDEGP Biotech Zynex Medical Holdings ZYNX 7/22/13 Lone Tree Undisclosed Alliances Advanced Brain Medical Device Monitoring

32 BIOSCIENCE COLORADO 2015-2016 2013-2014 ACQUISITIONS

2013 ACQUISITIONS OF COLORADO COMPANIES Company Public Ticker Close Date City $USD M Company Location Industry Type Sound Surgical Technologies LLC. 1/29/13 Louisville 35.5 Solta Medical, Inc. Hayward, CA Medical Device Inviragen, Inc. 5/8/13 Fort Collins 35.0 Takeda America Japan Biotech Holdings, Inc. Lanx, Inc. 8/7/13 Broomfield Biomet, Inc. Warsaw, IN Medical Device

2013 COLORADO COMPANY ACQUISITIONS Company Public Ticker Close Date City $USD M Company Location Industry Type DaVita, Inc. DVA 1/7/13 Denver Fresenius Medical Portugal/Poland Medical Device Care Spectranetics Corporation SPNC 1/7/13 Colorado Springs 5.5 + Upstream Peripheral Israel Medical Device milestone Technologies, Ltd. pymts Terumo BCT 3/20/13 Lakewood Medservice Poland Medical Device DaVita, Inc. DVA 5/21/13 Denver 4.42 B HealthCare Partners Torrance, CA Medical Device LLC Terumo BCT 11/4/13 Lakewood GADA Turkey Medical Device Clovis Oncology Inc CLVS 11/19/13 Boulder 196.0 EOS S.p.A. Biotech

2014 ACQUISITIONS OF COLORADO COMPANIES Company Public Ticker Close Date City $USD M Company Location Industry Type Corgenix Medical Corporation CONX 8/28/14 Broomfield 16.0 Orgentec Diagnostika Germany Diagnostics Covidien COV 1/27/15 Boulder 42.9 Medtronic Minneapolis, MN Medical Device MusclePharm Corp. MSLP 1/6/14 Denver Undisclosed BioZone Pharmaceu- Richmond, CA Pharmaceutical ticals, Inc Novus Biologicals 7/2/14 Littleton 60.0 Bio-Techne Minneapolis, MN Biotechnology Corporation TriZetto 9/15/14 Englewood 2.7 B Cognizant Teaneck, NJ Health IT

2014 COLORADO COMPANY ACQUISITIONS Company Public Ticker Close Date City $USD M Company Location Industry Type Spectranetics Corporation SPNC 6/30/14 Colorado Springs 230.0 AngioScore, Inc. Fremont, CA Medical Device

2013-2014 NEW COMPANIES

Company City Industry Type Access Sensor Technologies Fort Collins Diagnostics EnteroTrack Denver Diagnostics Galaxy Ophthalmics Aurora Medical Device Green Sun Medical Fort Collins Medical Device Growcentia Fort Collins Agricultural Biotech MicroChemica, LLC Fort Collins Agricultural Mile High Ophthalmics Aurora Medical Device Ocugen Aurora Biotechnology Helping Ocugen Aurora Biotechnology OcuTherix Aurora Medical Device Bio Companies Recreo Pharma Aurora Pharmaceutical Sapien LLC Fort Collins Medical Device yuScience LLC Aurora Biotechnology Make Smart,

Company City Industry Type 7YVÄ[HISL Gates Biomanufacturing Facility Aurora Biotech Leo Technologies Boulder Diagnostics Real Estate Membrane Protective Technologies Inc. (MPTI) Fort Collins Biotech MycoTechnology Aurora Biotech Decisions. Ocugen Aurora Biotech Precision Biopsy Aurora Diagnostics RX Assurance Boulder Digital Health Contact Dustin Whistler SixOne Solutions Aurora Biotech 303.800.8223 • fortebiobusiness.com Tissue Fusion Colorado Springs Medical Device Verkko Biomedical Aurora Biomaterials Z Biotech Aurora Biotech

Information provided by BioPharm Insight 2015-2016 BIOSCIENCE COLORADO 33 GRANT PROGRAMS: INNOVATION ENGINES

Over the past eight years, Colorado has developed comprehensive grant programs to build the state’s bioscience ecosystem.

BioFrontiers Institute nitially, the Bioscience Discovery Evaluation Grant Program UNIVERSITY OF COLORADO (BDEGP) was created in statute in 2006, to support the development of novel technologies and advance commercialization. The state saw the success of the BDEGP as a catalyst to create the Advanced Industries (AI) Accelerator Programs through legislation in 2013, to align with seven advanced industries – aerospace, technology, engineering, energy, electronics, manufacturing, and bioscience. The economic impact of these industries account for nearly 30 percent of the state’s wage earnings, nearly 30 percent of the total sales revenues across all industries within the state and nearly 35 percent of the state’s total exports. The AI Accelerator Program off ers three grant types – Proof of Concept, Early-Stage Capital and Retention, as well as Infrastructure. Additionally, the Advanced Industries Export Grant Program supports small and medium-sized business in the advanced industries and off sets international business development and related marketing costs. The programp has created 46 new companies, 426 ddirect jobs and $469.1 million in additional investment, therefore leveraging the State’ste’s investment 12.78 times the initial amount.t.

For Bioscience, the BDEGP and AI Programs have provided 285 grants since 2006, totaling approximately $36.7 million. The complete economic impact of this funding has been significant. The program has created 46 new companies, 426 direct jobs and $469.1 million in additional investment, therefore leveraging the state’s investment 12.78 times the initial amount. These programs exemplify the importance of investment to promote growth and sustainability to drive innovation, accelerate commercialization and encourage public-private partnerships.

34 BIOSCIENCE COLORADO 2015-2016 Proof of Concept Grants Investigator: William Sauer, MD Institution: University of Colorado by Institution Title: A Partially Insulated Catheter for Directed and Tailored Radiofrequency Ablation Investigator: Achim E. Klug, PhD Impact: Catheter ablation of cardiac tissue with Institution: University of Colorado radiofrequency (RF) energy is routinely performed for the treatment of a variety of arrhythmias. All radiofrequency Title: Chip-Guided Neurosurgery ablation catheters are radially symmetric at the catheter Impact: A device and soft ware system that can wirelessly tip cylinder, thus allowing for circumferential RF. However, report, with very high accuracy, angular orientation as there is an unmet need in catheter design that allows for well as acceleration in the three cardinal axes of the object a more tailored approach during RF ablation in which it is attached to. The device can easily be integrated into circumferential ablation is not desired. An insulated existing O.R. technology and can interface with existing catheter, where RF energy is concentrated to a single side, soft ware and hardware to increase the accuracy of such will allow for a more eff ective ablation at lower powers. equipment, and ultimately improve the outcomes of many It will also permit RF delivery deeper into tissues and is neurosurgical procedures. therefore useful for diff icult arrhythmias arising from deep structures, such as the septum, papillary muscle and cavo-tricuspid isthmus. Investigator: Xiao-Jing Wang, PhD Institution: University of Colorado Investigator: Christopher M. Yakacki, PhD Title: Developing Novel Biologics to Treat Oral Mucositis and Diabetic Wounds Institution: University of Colorado Impact: Oral mucositis is one of the worst toxicities of Title: Development and Biological Evaluation of Porous, radio- or chemo-therapy in cancer patients. Currently, Patient-Specific Interbody Fusion Cages there is no eff ective therapy to treat severe oral muco- Impact: Current approaches to lumbar interbody fusions sitis. Chronic skin wounds aff ect 6.5 million patients in (LIFs) involve using devices made from traditional solid the United States; treatment costs exceed $25 billion materials to restore disc height and provide stability for annually. Diabetic patients are particularly susceptible fusion. These designs do not evenly distribute loads across to impaired wound healing. the vertebral endplates and can lead to micro-fractures and subsidence (i.e. loss of disc height). Subsidence combined with the supra-physiological stiff ness values of the devices Investigator: Gregory T. Everson, MD can contribute to adjacent-level disease. PPPs are a new Institution: University of Colorado class of aromatic polymers with strength and stiff ness TItle: HepQuant (HQ)-SHUNT Correlates of Hepatic Venous values higher than polyetheretherketone (PEEK), which is Pressure Gradient (HVPG) Testing a standard in polymeric implantsThe investigators have developed a method to tailor the porosity of the device to Impact: HQ-SHUNT fulfills an unmet need in drug match the mechanical properties across the entire vertebral development and clinical trials of liver disease – as a endplate to better distribute forces and reduce subsidence. noninvasive, accurate, safe, easy-to-administer and cost-eff ective alternative to HVPG testing. Drug companies are investing billions of dollars in developing new anti-fibrotic drugs to treat the ~30 million Americans with liver fibrosis/cirrhosis. These eff orts are hindered EJ BioMed because the best method to quantify liver disease An Eldon James Company progression and eff icacy of new drugs is HVPG, which is invasive, diff icult to perform and very expensive. Colorado manufacturer for tubing and connectors for over 28 years ISO Class 7 cleanroom manufacturing Investigator: Todd J. Grazia, MD Adhesive FREE assemblies Institution: University of Colorado Partnership engineering Title: Clinical Development of Autologous CD117+ Progeni- www.EJBioMed.com tor Cell (PC) Therapy for Solid Organ Transplantation 970.667.2728 Impact: Current clinical outcomes for solid organ and other tissue/cellular transplants remain poor. New novel therapeutics to improve rates of rejection (and survival as a consequence) and decrease reliance on immune suppressants (and their severe morbidities) are a must. INJECTION MOLDINGtEXTRUSIONtASSEMBLIES MADE IN THE USA

2015-2016 BIOSCIENCE COLORADO 35 Investigator: Kimberly E. Newman, PhD Investigator: Yevgeniy Vinogradskiy, PhD Institution: University of Colorado Institution: University of Colorado Title: Ultrasonic System for Activity and Fall Monitoring Title: 4DCT-Ventiliation: A New Lung Function Imaging Impact: The creation of electronics for remote health Modality for Radiation Therapy monitoring. As the average population age increases Impact: Physicians would be able to use 4DCT-ventilation worldwide, automated tools to ensure quality of life to help evaluate whether it is safe to off er radiation become increasingly necessary and valuable. Elderly indi- treatment to patients. 4DCT-ventilation images can be viduals who are living alone have high risk of undetected used to perform functional avoidance; where the radiation injury that reduces the ability to maintain independence beams are designed and placed such that they are not while providing safety. Undetected falls are a leading directed through the functional portion of the lung. cause of hospitalization. 4DCT-ventilation could be used as an imaging biomarker to assess response to therapy and help guide care.

Investigator: Kenneth N. Maclean, PhD Institution: University of Colorado Investigator: Jeff rey L. Olson, MD Title: Cystathionine as Treatment for Vascular Calcification Institution: University of Colorado Impact: Vascular calcification is widely held to be an Title: Wave Mini-Shunt Device for Glaucoma Treatment important contributor to cardiovascular morbidity and Impact: The current standard of care for treating the mortality of patients with advanced atherosclerosis linked blinding complications of glaucoma revolves around to aging, diabetes mellitus and chronic kidney disease topical medicines, laser treatments, and surgery for the (CKD). Vascular calcification is associated with fragmen- most advanced cases. Surgeries have a very high failure tation and reduction of elastic fibers in the arterial wall, rate in these patients who are most at risk (nearly 50 vascular stiff ening and hence increased cardiac overload. percent fail at five years), and cannot be customized to the Cystathionine (R-S-(2-Amino-2-carboxyethyl)-L-homocys- individual patient. The Wave Mini-shunt device obviates teine) is a non-proteinogenic thioether containing amino both of these drawbacks. The device allows surgeons acid. During the past five years, we have shown that the to post-operatively control the rate of flow through the thioether amino acid cystathionine exerts very strong device, allowing better, customized treatment for patients. protective eff ects against ER stress-induced injury in the liver and kidney. Investigator: Matthew Wallenstein, PhD Institution: Colorado State University Investigator: Balaji Sridhar, PhD Title: Commercialization of Advanced Soil-Based Microbial Institution: University of Colorado Solutions for Agriculture Management Title: Evaluation of Photodegradable Polymer Networks Impact: This technology addresses the global agricultural for Encapsulation and Thermal Stabilization of Tempera- industry problem of an ever greater need for phosphate ture Sensitive Biological Components fertilizer to get the crop yields necessary to feed the Impact: Our solution is portable, convenient and reliable. world and, hopefully, lessen the groundwater and aquatic It is designed to eliminate the diff iculties associated with pollution problems cause by phosphorus runoff . vaccine transportation and delivery. We are enabling vaccines to be delivered to places that need them the most. Investigator: Yan Vivian Li, PhD and Meghan E. Suter, PhD Institution: Colorado State University Title: Smart Wound Dressings for the Detection and Colormetric Indication of Bacterial Infection Impact: Bacterial infections in wound dressings are diff icult to monitor even with frequent re-dressing of wounds. This research proposes to create a “smart textile” bandage that displays a change in color when pathogenic bacteria is present. These bandages will be made from a nanofiber matrix that has detection molecules within embedded vesicles.

36 BIOSCIENCE COLORADO 2015-2016 Investigator: Randy Bartels, PhD Investigator: Kevin Brown, MD, Jeff rey Swigris, DO and Institution: Colorado State University Steve Groshong MD, PhD Title: Construction of a Whole Brain Optical Imager Institution: National Jewish Health Product Prototype Title: Right Flow Oxygen Delivery System Impact: The proposed technology could allow – for the first Impact: Hypoxemic patients need supplemental oxygen time – imaging of epi (back-collected) fluorescent and ab- to maintain a normal blood oxygen level. Our project aims sorption imaging from biological specimens at an unprec- to develop an oxygen delivery system that monitors blood edented speed and volume (up to 1 cm3). This technology oxygen saturation and physical activity, and in response will initially be designed for scientific institutions engaged in alters supplemental oxygen flow rates to maintain a normal neural imaging but will have clinical applications as well. blood oxygen saturation at rest, with activity and sleep.

Investigator: Dean A. Hendrickson, DVM Investigator: Kent Voorhees, PhD and Chris Cox, PhD Institution: Colorado State University Institution: Colorado School of Mines Title: Development of a Computer Assisted Physical Title: Rapid Point-of-Care LFCC Detection of Serum Examination/Palpation Model for Medical Training Cancer Biomarkers Impact: This technology will allow medical and vet- Impact: The development of Lateral Flow Capillary erinary personnel to be trained to accurately identify Concentration (LFCC) showed success in phage-based abdominal organs while providing immediate feedback bacterial detection, identification and antibiotic resistance to the user and trainer. determination with a quantifiable surface enhanced spectroscopy across a large number of analyte types. This project will establish LFCC detection of serum cancer Investigator: Matthew Wallenstein, PhD biomarkers for prostate and breast cancers. Institution: Colorado State University

Title: Prototype Formulation and Field Testing of Microbial Investigator: Steve Boyes, PhD Biostimulants for Greener Lawns Institution: Colorado School of Mines Impact: This technology details a method of identifying and selecting populations of soil microbes that are capable Title: Polymer Modified Nanoparticles as Contrast Agents of increasing the availability of phosphorus in soil. These for the Non-invasive Measurement of pH in vivo “consortia” of microbes modify the phosphorus in the soil Impact: The extracellular pH (pHe) in cancer tumors that is unavailable for plant uptake in its unmodified form. is important in producing more aggressive cancer This microbial modification could be used in formulations phenotypes and causing metathesis. A pHe responsive by the Turf industry for greener lawns. agent for MRI and CT that improves the selectivity and sensitivity of pHe measurements has been developed which could lead to better and quicker monitoring, and Investigator: Erwin Gelfand, MD, and Greg Miknis, PhD treatment adjustments. Institution: National Jewish Health

Title: Small Molecule Inhibitors of Pim1 Kinase for the Investigator: Hongjun Liang, PhD Treatment of Allergic Disease Institution: Colorado School of Mines Impact: Our work at National Jewish has shown that PIM kinase plays a crucial role in allergic diseases. In collabora- Title: Virus-Mimicking Polymer Molecular Brushes as a tion with CSU, this project aims to develop and test novel Novel Family of Highly Potent Antimicrobial Agents PIM kinase inhibitors in models of allergic disease. This Impact: This project will optimize antimicrobial activity project could lead to the creation of drug candidates for by tuning the nanoscale architectures of synthetic mimics allergic conditions. of antimicrobial peptides. The goals are: (1) design and synthesize polymer molecular brushes with well-defined characteristics; (2) determine the structure-dependent an- Investigator: Vijaya Knight, MD, PhD and Bruce Lanser, MD timicrobial potency and selectivity of polymer molecular Institution: National Jewish Health brushes against two model bacteria and their interaction with human red blood cells. Title: Basophil Reactivity to Specific Food Allergens as a Superior Predictor of Oral Food Challenge Outcomes than Specific IgE Levels or the Skin Prick Test Impact: Food allergies currently aff ect both children and adults in the United States and are on the increase. Our project focuses on the development of a basophil activation diagnostic assay for food allergens that would be superior to the currently available IgE and skin prick test.

2015-2016 BIOSCIENCE COLORADO 37 Early-Stage Capital and Retention Grants 2014 - 2015 Early-Stage grants provide needed funding to companies commercializing technologies by backing research, testing and business development activities that will prepare them for additional third-party financing.

Bioscience Discovery Evaluation CoramiR Grant Program (BDEGP) CoramiR is developing tests for pediatric heart failure patients. Based on microRNA biomarkers found in KromaTiD circulating blood, these tests will help physicians to www.kromatid.com non-invasively risk-stratify potential transplant candidates. KromaTiD’s patented dGH™ chromosome imaging platform enables detection of all types Biomimetix of chromosomal rearrangements including www.omnibiopharma.com previously undetectable cryptic inversions. Biomimetix is focused on the development of a novel metalloporphyrin antioxidant mimetic for Mighty Oak Medical topical treatment of inflammatory dermatologic www.mightyoakmedical.com diseases (psoriasis and atopic dermatitis) Mighty Oak’s FIREFLY Technology is a series of patient matched pedicle screw trajectory Galaxy Ophthalmics guides that help create pilot and tapped holes www.galaxy-eyes.com specific to a particular patient’s vertebrae. Galaxy Ophthalmics is developing technologies related to new therapies for Glaucoma, Wet and Dry Siva Therapeutics Macular Degeneration and Diabetic Retinopathy. www.sivatherapeutics.com Siva Therapeutics Inc. (Siva) is focused on the Double Helix discovery, development and commercialization www.doublehelixoptics.com of nanotechnology therapies that improve cancer Double Helix develops and commercializes computational treatment options for patients and physicians. optical-digital technologies used in range estimation, super-resolution microscopy and 3D imaging.

Snoasis www.snoasismedical.com Snoasis is focused on the development and commercialization of human placental tissue products for perioplastic surgery.

Advanced Industry Accelerator Grant Program (AI) MBio Diagnostics, Inc. www.mbiodx.com MBio Diagnostics is dedicated to improving patient outcomes by enabling comprehensive diagnostics at the point-of-care (POC) from a single patient sample.

Prima-Temp, Inc. www.prima-temp.com Prima-Temp’s continuous temperature sensors and associated soft ware allow for the measurement of true core body temperature, with the potential to address a multitude of applications, including fertility, early disease detection, sleep disorders, drug therapy, weight control and exercise.

Lifeloc www.lifeloc.com Lifeloc Technologies, Inc. is a provider of precise, reliable and easy-to-use portable breath alcohol testing instruments (breathalyzers).

38 BIOSCIENCE COLORADO 2015-2016 Commercialization Infrastructure Grants Commercialization Infrastructure grants support joint eff orts of industry and academia to create resources that are essential for industry growth. BDEGP Commercialization Infrastructure funds have funded four organizations over a number of years. Grantees identify and manage technologies, and support collaboration to bring necessary expertise together to advance novel Colorado biotechnologies to commercialization.

BIOSCIENCE DISCOVERY EVALUATION GRANT PROGRAM (BDEGP)

The Colorado Center for Drug Discovery The BioFrontiers Institute (C2D2) www.biofrontiers.colorado.edu www.c2d2.org A state-of-the art research and education facility that Based at Colorado State University, C2D2 is a resource to links the basic sciences, engineering, clinical practice and faculty at all Colorado research universities, bringing biolo- industry at the University of Colorado’s Boulder campus gy and chemistry faculty together to use chemical libraries, to support breakthrough developments in areas such as computational resources, bioinformatics, cheminformatics, engineering human tissues, RNA enzyme and aptamer database support, virtual high throughput screening, and based pharmaceutical, biorefining and genetics. Grant Computer Aided Drug Design to pharmacologically validate funds support equipment, resources and personnel costs drug candidates with patent-protected chemical matter to develop the core facilities of the Institute. and innovative therapeutics for unmet medical needs. The University of Colorado, Skaggs The Colorado Institute for Drug, Device School of Pharmacy at Anschutz and Diagnostic Development (CID4) www.ucdenver.edu/pharmacy www.cid4.com Developed an HTS/HCS (high throughput/content CID4’s mission is to eff iciently transform emerging life screening) Core Facility for drug discovery. This resource science technologies into commercial successes. We do has been utilized by more than 100 researchers and this by employing an experienced Technical and Business companies advancing the science and helping to secure Advisory Committee to identify potential opportunities intellectual property. and assist in formulating development strategies combined with an advanced leadership team to ensure speed to market, putting new products and services to work where they are needed.

2015-2016 BIOSCIENCE COLORADO 39 DIRECTORY

41-50 Medical Device, Diagnostic and Related Companies

50-56 Biotechnology, Pharmaceutical and Related Companies

56-57 Biofuels and Related Companies

57-59 Research and Education Institutions

60 Member Foundations

60-62 Member Service Providers

Fort Collins Sterling

Greeley

Longmont

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Telluride C = CBSA MEMBER

MED TECH COMPANIES Advanced Research Instruments Corporation Golden 2C Technologies www.aricorp.com Denver Produces preamplifiers for PMTs and www.2ctechcorp.com electron multipliers, high-voltage power Development, validation, and commercialization supplies, counters and timers, precision- of “SeeQ” intraocular implant as a next rate meters, and image analyzers for generation in vivo system for stimulating scanning electron microscopes. degenerated retinal cells and restoring vision. Aesthetic Technologies Abilities Unlimited Golden Colorado Springs, Denver www.parisianpeel.com www.auiop.com Manufactures and sells Parisian Peel® Provides artificial limbs and custom brand microdermabrasion systems and orthopedic appliances. accessories along with skin care products to medical and spa professionals. Able Planet Wheat Ridge Aestis, Inc. www.ableplanet.com Boulder Developing an extensive line of audio and www.altitudetraining.com/aux/about/aestis communications products that are usable by Develops a treatment for obesity through people with all levels of hearing, and provide controlled hypoxia technology. The two a means whereby users can listen at lower principal components are the air separation volumes without compromising full rich sound. unit and proprietary control system.

AbleLink Technologies Agilent Technologies Colorado Springs Colorado Springs www.ablelinktech.com www.agilent.com Addresses the need for well-researched Provides core electronic and bio-analytical cognitive support technologies for indi- measurement tools to advance life viduals with intellectual disabilities. science research.

Access Sensor Technologies AktiVax Fort Collins Boulder, Aurora Paper-based diagnostics for industrial and www.aktivax.com personal environmental monitoring. Developing novel reconstitution, safety syringes for vaccines and biologics. Accu-Tube Corporation Englewood C Allison Medical www.accutube.com Littleton Manufactures standard and custom size www.allisonmedical.com stainless steel hypodermic medical tubing. Develops a variety of disposable products that serve the healthcare needs of retail/pharmacy, C Acertara Acoustic Laboratories, LLC acute, alternate, and home care markets. Longmont www.acertaralabs.com C AlloSource Independent ISO/IEC accredited Centennial medical ultrasound acoustic measure- www.allosource.org ment and testing laboratory. Develops, processes and distributes life-enhancing bone and tissue allograft s Actium Biosystems to the medical community. Boulder www.actiumbio.com AllPro Developing new technology to treat Broomfield cancer through the use of nanoparticles www.allprodental.com to weaken and destroy cancer cells. Produces a large selection of non-latex prophy cups, prophy angles and other dental products. Advanced MicroLabs, LLC Fort Collins Alpha Mold West www.advancedmicrolabs.com Broomfield Researches and develops chemical analytical www.alphamoldwest.com instruments in “Lab-on-a-chip” format. Plastic injection mold-making facility for the medical industry.

2015-2016 BIOSCIENCE COLORADO 41 Angioslide, Inc Auri-Stim Medical BioCare Systems, Inc. Wheat Ridge Denver Parker www.angioslide.com www.net1device.com www.biocaresystems.com Privately held medical device company that Offers an alternative therapy for migraine head- Designs, develops and markets patent-protected, developed a unique Embolic Capture Angioplasty aches, hormonal migraine, chronic headaches, FDA cleared, new health-care devices (LumiWave™) solution, PROTEUS™, which provides a premenstrual syndrome (PMS), nicotine and that use deep-tissue light therapy to decrease pain, combination of PTA balloon and embolic capture. narcotics addictions using the NET-1000 device. accelerate healing and improve quality of life.

Animark, Inc. Avantes C Biodesix, Inc. Aurora Broomfield Aurora, Boulder www.animark.us www.avantes.com www.biodesix.com Manufactures and sells ultrasound pregnancy detec- Produces, develops and sells spectrometers, Molecular diagnostics company advancing the tors and ovulation predictors for livestock breeding. light sources, fiber optic multiplexer, fiber revolution in personalized medicine by providing optic cables, software, fiber optics and physicians timely and clinically useful information. C Apdyne Medical Company accessories to the medical device industry. Denver BioFusionary Corporation www.apdyne.com C Baby Genes Inc. Wheat Ridge Manufactures and distributes the Apdyne Phenol Golden www.biofusionary.com Applicator Kit used to anesthetize the tympanic www.babygenes.net Designs and develops medical devices and membrane during in-office myringotomy procedures. Genomics services company using Next-Gen- biomaterials that shape, tighten and seal tissues. eration Sequencing assays to deliver Aqueous Biomedical more advanced newborn screening. C BiOptix Colorado Springs Boulder www.aqueousbio.com Bal Seal Engineering, Inc. www.bioptixinc.com Develops biocompatible materials and geo- Colorado Springs Offers a new, patented approach to label-free metric designs that can be applied to stents, www.balseal.com analysis, called Surface Plasmon Enhanced shunts, artificial organs and drug-delivery Produces seals and canted-coil springs for sealing, interferometry (SPE). devices. Its first product, the Oculieve™ shunt, holding, latching and electrical contact in a variety is designed to control over-pressurization of applications throughout the medical market. Biotricity Medical Inc. inside the eye caused by glaucoma. Aurora Baxter Healthcare Corporation www.biotricitymedical.com C ArcScan, Inc. Englewood Research and manufacturing company specializing Morrison www.baxter.com in developing long-term power requirements for www.arcscan.com Baxter International, through its subsidiaries, implanted devices based on bioelectric generation. Early stage med device startup developing VHF develops, manufactures and markets products Ultrasound for comprehensive ophthalmic imaging. that save and sustain the lives of people with BioVision Technologies, Inc. hemophilia, immune disorders, infectious Golden Arcturus Star Products LLP diseases, kidney disease, trauma and other www.biovisiontech.com Cortez chronic and acute medical conditions. Develops and manufactures micro-visualization www.lymphstarpro.com solutions that enable endoluminal and minimally Pioneering Vibrational Energy Therapy for the Beckman Coulter invasive medical procedures in both human and wellness and beauty professions. Vibrational Fort Collins veterinary medicine. The imaging technologies energies incorporate subtle low frequencies of www.beckmancoulter.com and customized micro-endoscope solutions are light, sound and electrical waves. Its therapeutic Develops and produces instruments integrated to reduce incision size and speed healing. specialty is in the area of lymphatic health. for the diagnostic industry. Specializes in the fields of immunocytochemistry, C BodySync, Inc. ASI Medical, Inc. flow cytometry and microbiology. Aurora Centennial www.bodysync.com www.asimedical.net Bell Dental Products, LLC Applies evidence-based genetic information Developer of specialized mobile and inte- Englewood to develop personalized products that help grated dental carts as well as unique dental www.belldental.com individuals achieve their health goals. instruments for the modern dental office. Designs, develops and manufactures precision dental equipment based on electric motor technology. Boulder Innovation Group, Inc. C Aspire Biotech, Inc. Boulder Colorado Springs BiO2 Medical, Inc www.boulderinnovators.com www.aspirebiotech.com Golden Develops and manufactures image-guided Provides contract services for all phases of product www.bio2medical.com surgical navigation digitizers and industrial development from concept to launch, and produces Medical device manufacturer founded to design, 3D capture and modeling equipment. its own skin sealant and wound-closure adhesives. develop and subsequently manufacture a range of medical products in response to clinical needs. Broadwest Corporation Boulder www.broadwest.com Develops and manufactures ergonomic mammography viewing equipment.

42 BIOSCIENCE COLORADO 2015-2016 C = CBSA MEMBER

C. R. Bard, Inc./ Medivance Chart Industries, Inc. Corgenix Medical Corporation Louisville Denver Broomfield www.medivance.com www.chartindustries.com www.corgenix.com Leading multinational developer, manufacturer Manufacturing services to companies that want The Colorado facility is engaged in research, and marketer of innovative, life-enhancing medical to out-source some or all of their manufacturing development, manufacture and marketing technologies in the fields of vascular, urology, processes, and to companies that have capacity of in vitro diagnostic products for use in oncology and surgical specialty products. issues with their current manufacturing resources. disease detection and prevention.

Canberra Industries Clean Room Devices, LLC C Crosstrees Medical, Inc. Arvada Westminster Boulder www.canberra.com www.cleanroomdevices.com www.crosstreesmedical.com Manufactures and supplies analytical instru- Manufactures products that are engineered Privately-held company developing advanced de- ments, systems and services for radiation specifically for “clean room” environments. vices and instruments for the treatment of vertebral detection and radiation monitoring. body compression fractures (VCF) in the spine. Cochlear Americas Care Electronics, Inc. Centennial Darkhorse Technologies Broomfield www.cochlearamericas.com Nederland www.medicalshoponline.com Global leader in implantable hearing solutions. Commercializes a patented technology for Offers a range of electronic monitoring Manufacturer of Nucleus cochlear implants and affordable, hand-carried, battery operated and alarm equipment for the home- the Baha programmable bone conduction system. instruments for on-site genetic detection health and long-term care markets. using Polymerase Chain Reaction (PCR). Colibri Heart Valve Car-May LLC Broomfield DataWave Technologies Corporation Berthoud www.colibrihv.com Loveland www.car-may.com Researches and develops novel heart www.dwavetech.com Unlike basic metering pumps, Car-May’s systems valve technologies. Manufactures a wireless and battery-free device for provide pumping capability, fluid measurement acquiring and transmitting data from electrodes and and flow control all in one compact module. Colorado Laser Technologies, Inc. other biosensors to a receiver placed meters away for Colorado Springs electrophysiology, neurophysiology and physiology C Cascade TEK www.coloradolasermarking.com related research on both humans and large animals. Longmont Provides YAG laser engraving technology, as www.cascadetek.com well as CO2 and YAG laser cutting services. C dBMEDx Medical device testing laboratory specializing Littleton in package testing, accelerated aging, Colorado Precision Products, Inc. www.dbmedx.com photostability, UV, temperature/humidity, Boulder Developing breakthrough realtime clinical vibration and shock testing services. www.coloradoprecision.com decision and patient monitoring devices using Provides diamond turned and polished patented, non-invasive scanning technology. C CEA Medical Manufacturing optics/parts. Fabricator of X-ray telescope Colorado Springs optical components. Produces and offers air Denver Optic Company www.ceamedicalmanufacturing.com bearing LVDT contact linear measurement Englewood Provides product development, complete systems, .05 microinch resolution. www.eyeprosthetics.com product assembly, packaging, manufacturing Specializes in the fitting and fabrication and design services to the medical industry. Confi-Dental Products Company of two types of ocular prosthesis. Louisville C CeraPedics, Inc. www.confi-dental.com C DePuy Synthes, Companies of Westminster Manufactures a wide range of dental and Johnson & Johnson www.cerapedics.com healthcare products including composites, Monument Developing and commercializing novel cements, creams, lotions and ointments. www.synthes.com osteobiologic products based on a proprietary Develops, produces and markets instruments, small peptide technology, P-15™ on anorganic CONMED Electrosurgery implants and biomaterials for the surgical bone mineral (ABM). Centennial fixation, correction and regeneration of the www.conmed.com human skeleton and its soft tissues. C CereScan Designs and manufactures RF electrosurgical Littleton generators and accessories of the highest Desert Glass Works www.cerescanimaging.com quality, safety and value for use in surgical Colorado Springs Specializes in state of the art functional brain procedures performed in virtually every hos- www.dgw.com imaging utilizing a proprietary process including the pital, surgery center and physician’s office. Manufactures quartzware for the latest generation high resolution gamma camera, medical and research industries. the industry’s leading brain image reconstruction CoorsTek Medical software, specially trained board-certified Golden Diazamed physicians and research-based knowledge to www.coorstek.com Fort Collins provide unparalleled diagnostic medical reports. Custom engineering, materials expertise, www.diazamed.com operational excellence and rapid execution. Development of advanced materials and CoorsTek Medical works with product utilize leading technologies to create innovators and manufacturers to turn more biocompatible surfaces. great ideas into life changing realities. 2015-2016 BIOSCIENCE COLORADO 43 Die Cut Technologies Empirical Testing Corporation Fischer Medical Technologies, Inc. Northglenn Colorado Springs Broomfield www.diecuttech.com www.empiricaltesting.com www.fischermti.com Offers precision material conversion, skilled Provides medical device testing services that add Designs, manufactures, and markets assembly and manufacturing efficiencies, value throughout the product development cycle, imaging systems for the screening including cleanroom facilities. with a focus on spinal implant device testing. and diagnosis of breast cancer.

Directed Energy Solutions C Empirican Group LLC FitBionic Colorado Springs Denver Boulder www.denergysolutions.com www.empirican.com www.fitbionic.com Develops advanced laser and optical device Empirican is a site management and subject Creating groundbreaking experiences for amputees solutions for medical applications. enrollment system for the digital age. and prosthetics based on organic design. We utilize our network of our affiliate investi- DNTLworks Equipment Corporation gators – primary care physicians, cardiologists C FlashBack Technologies Centennial and neurologists – to complete clinical trials Longmont www.dntlworks.com in a rapid, ethical and high-quality manner. www.flashbacktechnologies.com Manufactures portable, mobile and Fast, non-invasive detection of acute blood self-contained dental systems. Encision, Inc. loss volume and prediction of cardiovascular Boulder collapse in emergency situations. Double Helix www.encision.com Boulder Designs and manufactures innovative surgical C Fluonic www.doublehelixoptics.com devices. Developed AEM® Laparoscopic Instruments Boulder Double Helix LLC develops and commercializes to improve electrosurgery and reduce the chance www.fluonic.com computational optical-digital technologies used for patient injury in minimally invasive surgery. Develops infusion therapy systems with disposable in range estimation, super-resolution microscopy sensors for OEM and proprietary pumping systems. and 3D imaging. Double Helix’s core technologies C EndoShape, Inc. include the patented Double Helix-Point Spread Boulder, Aurora FOOTBEAT Function method for 3D super-resolution imaging. www.endoshape.com Grand Junction Manufactures surgical and medical instruments www.footbeat.com dpiX, Inc. focusing on shape memory polymer Mobile technology to improve quality Colorado Springs devices for endolumenal application. of life and athletic recovery by en- www.dpix.com hancing lower body circulation. Produces high-resolution amorphous silicon es2 technologies, inc. (a-Si) sensor arrays for medical X-ray imaging. Englewood Futura Surgical Inc. www.es2technologies.com Wheat Ridge C E.I. Medical Imaging Developing proprietary devices and contract design. www.futurasurgical.com Loveland Development, manufacture and www.eimedical.com C Evergreen Research, Inc. sales of orthopedic products. Manufacturer of highly portable and ruggedized Golden ultrasound devices for the veterinary industry. www.evergreenresearch.com C Galaxy Ophthalmics Offers a complete range of development services Denver C EJ BioMed – A Division of from product definition and feasibility studies www.galaxy-eyes.com Eldon James Corporation through detailed design to pilot-run and low-vol- Galaxy Ophthalmics is developing technologies re- Denver ume production to the medical device industry. lated to new therapies for Glaucoma, Wet and Dry www.EJBioMed.com Macular Degeneration and Diabetic Retinopathy. Manufactures, assembles and packages PVC Free Extreme Diagnostics tubing and connectors in a single cleanroom Boulder GE Analytical Instruments environment. Custom design and product www.extremediagnostics.com Boulder development available. ISO 13485:2003, ISO Develops noninvasive measurement systems, www.geinstruments.com 9001:2008, and ISO/TS 16949:2009 certified including optical systems such as custom Manufactures instruments used to measure holographic and interferometric instruments. total organic carbon (TOC) in water for pharma- Electronic Materials, Inc. (EMI) Specializes in structural health monitoring, ceutical applications and medical research. Breckenridge nondestructive testing and materials processing. www.emiuv.com Genesee BioMedical, Inc. Offers a complete line of EMCAST UV adhesives, Falcon Rehabilitation Products Denver epoxies, sealants, encapsulants and coatings. Denver www.geneseebiomedical.com EMI also offers room temperature, thermal www.falconrehab.net Manufactures cardiac surgery instruments and visible light cure adhesive systems. Designs and builds high quality, innovative and devices. quadriplegic seating systems and accessories Ellab, Inc. (Falcon Rehabilitation Products, LaBac Gnathodontics, Ltd. Centennial Seating Systems, Gel Ovations). Lakewood www.ellab.com www.gnatho.com Manufactures thermal validation solutions C Firefly Medical, Inc. Specializes in functional dentistry, advanced for food and pharmaceutical industries. Fort Collins implant work, precision partial dentures, combi- www.fireflymedicalinc.com nation cases and metal-free fixed restorations. Designs and develops innovative durable medical 44 BIOSCIENCE COLORADO 2015-2016 equipment for clinical healthcare markets. C = CBSA MEMBER

C Grant Dental Technology Corporation C InDevR, Inc. Lanx, LLC/Biomet, Inc. Colorado Springs Boulder Broomfield www.grantdentaltech.com www.indevr.com www.lanx.com Dental implants and surgical/restorative Develops and manufactures biomedical Specializes in systems and implants for tools. Designs, develops and produces the instruments including molecular diagnostic all segments of spinal surgery. Integrating Proximer dental implant and associated assays, virus measurement systems and leading technology, intellectual property and surgical and restorative instruments. detection technologies for micro-arrays. state-of-the-art engineering, each product is designed to simplify surgery and improve the Green Sun Medical Infinity Photo-Optical Company quality of care for patients worldwide by providing Fort Collins Boulder surgeons with innovative spinal products. Green Sun Medical develops innovative treatments www.infinity-usa.com to address Adolescent Idiopathic Scoliosis Manufactures long-distance and continuously-fo- Lenox MacLaren Surgical Instruments (AIS) through non-fusion scoliosis solutions. cusable microscope technology, macro systems, Louisville internal-focusing devices and other lenses. www.lenoxmaclaren.com C Groesanoak Product Development, Inc. Manufactures precision orthopedic and Frederick Instec, Inc. neurological surgical instruments. www.groesanoak.com Boulder Creates innovative proprietary new medical www.instec.com Leo Technologies devices focusing on areas of injury management, Manufactures precision temperature con- Boulder neonatal care and performance monitoring. trollers and microscope hot stage systems www.leo-technologies.com for temperature cycling, food sciences, Our health requires a new way to monitor C Growcentia materials characterization, forensics, polymers hydration that’s both simple and accurate. Leo Fort Collins and liquid crystals and microbiology. Technologies hydration monitor affords simple, www.growcentia.com yet powerful biometric sensing and analytics Growcentia makes organic soil supplements Intelligent Imaging Innovations (3i) that makes consistent monitoring care-free. that naturally increase nutrient availability Denver to support healthy and vigorous plants. www.intelligent-imaging.com Logisens Corporation Designs and builds systems around the newest Fort Collins Hach Company automated fluorescence microscopes and www.logisens.com Loveland the most advanced peripheral devices. Develops biosensor and software technology, www.hach.com enabling a significant breakthrough in real-time Manufactures and distributes analytical Jorgensen Laboratories, Inc. measurement and reduction of stress. instruments and reagents used to test the Loveland quality of water and other aqueous solutions. www.jorvet.com C Lumed Designs and manufactures instruments Denver HEI Advanced Medical Operations that are used in the animal health field, www.lumedscience.com Boulder including specialty instruments, surgical Lumed Science Inc. is a company specializing www.heii.com suture and veterinary equipment. in creating medical devices that integrate and Develops and manufactures high-performance improve user vision. Our goal is to increase components, medical software, medical devices, and Jortek Surgical, Inc. visibility, simplify procedures, lower costs non-medical products. Produces microcircuits and Boulder and improve patient outcomes. subsystems for hearing and medical applications. www.jortek.com Develops innovative orthopedic de- C Luoxis Hirsh Precision Products, Inc. vices with a focus on joint and tissue Greenwood Village Boulder preservation and augmentation. www.luoxis.com www.hppi.com In-vitro diagnostics company focused on the Manufactures precision-machined and assem- C JustRight Surgical development and global commercialization of bled components for the medical industry. Boulder RedoxSYS™. The first and only research platform www.justrightsurgical.com that accurately, easily and completely provides C iC3D Health, LLC Developing precisely designed surgical a real-time assessment of redox balance. Centennial instruments that allow access to confined www.ic3dhealth.com spaces and often delicate structures. Magnelab, Inc. iC3D Health provides patient education, sales Longmont and marketing software to the elective surgery C Kestrel Labs, Inc. www.magnelab.com market the leads to greater conversion rates. Boulder Manufactures custom magnetic components www.kestrellabs.com (transformers/inductors) for the medical field. Illumasonix LLC Kestrel Labs combines internal research and Aurora development projects with consulting and Mayer Medical Technologies, Inc. www.alliedminds.com/subsidiaries/ilumasonix contract development of innovative, patient-mon- Grand Junction In partnership with Allied Minds, we will develop itoring concepts and other medical technologies. www.mayermedical.com and commercialize a new non-invasive vascular Mayer Medical Technologies, Inc. improves disease detection procedure, which will provide Kindara health and saves lives by innovating new near real-time assessment of detailed blood flow Boulder products, providing seed capital to medical patterns within the cardiovascular system. www.kindara.com start-ups, and assisting medical professionals Devoted to giving women the tools, in developing their product ideas. knowledge, and support to understand how their fertility works. 2015-2016 BIOSCIENCE COLORADO 45 C MBio Diagnostics C Mighty Oak Medical nSpire Health, Inc. Boulder Englewood Longmont www.mbiodx.com www.mightyoakmedical.com www.nspirehealth.com Develops rapid, on-the-spot clinical diagnostics Develops cutting-edge spinal technologies Develops, manufactures and markets respiratory and sample testing. Portable MBio multiplex for use in spine surgery. Develops the care products and services focused on cardio- analyzer and disposable cartridge enable FIREFLY technology, an affordable patient pulmonary diagnostics, respiratory core lab low-cost, rapid answers in 1-20 minutes. specific guide for spinal navigation. services and disease management solutions.

Medical Modeling, Inc. Mikron Corporation OcuTherix Golden Aurora Aurora www.medicalmodeling.com www.mikron.com www.ocutherix.com Produces highly accurate 3-D physical Supplies transfer machining systems for complex Non-invasive glaucoma treatment device. models of human bone structure parts, cutting tools with high-performance from imaging such as CT or MRI. standards, self medication and diagnostic devices. C Optibrand Ltd., LLC Fort Collins MedKeeper Mile High Ophthalmics www.optibrand.com Denver Aurora Developed optical imaging system for www.medkeeper.com www.milehighophthalmics.com veterinary diagnostics. Applications for hospital pharmacies. Secure, Ophthalmic device for enhanced hosted applications to promote pharmacy precision in cataract surgery. OptiEnz Sensors communications, compliance and productivity. Fort Collins Mind Studios www.optienzsensors.com C Medtronic Navigation, Inc. Colorado Springs Revolutionizing measurement capabilities for Louisville www.mind-studios.com organic chemical concentration; now providing www.medtronic.com A full-service product design and research studio continuous, real-time, in-place sensor solutions. At the forefront of surgical navigation solutions, housed within the University of Colorado at Colorado guiding the industry to a higher standard of care for Springs. Offers concept generation, advanced C Osypka Medtec Inc. several clinical specialties, including cranial neuro- prototyping, engineering and consumer research, Longmont surgery, functional neurosurgery, spinal, ENT, joint human factors design and manufacturing solutions. www.osypka-medtec.com replacement and orthopaedic trauma surgeries. Manufactures non-invasive hemodynamic Montview Biomedical Design Inc (MBD Inc.) and cardiac output monitors. Mesa Laboratories, Inc. Aurora Lakewood www.montviewbiomed.com Otologics, LLC www.mesalabs.com Designs, develops and creates engineering Boulder Provides dialysis meters and related solutions for the biomedical industry. Develops and commercializes surgically supplies to dialysis clinics world wide. implantable alternatives to conven- MuscleSound, LLC tional “in the ear” hearing aids. Metamatrix, LLC Denver Boulder www.musclesound.com OvaCue www.zorbent.com Developed a process to measure mus- Aurora Manufacturers of ZORBENT, an absorbant, cle glycogen content real time using www.ovacue.com is designed to leave no residue, reducing non-invasive ultrasound technology. Manufactures the OvaCue family of the risk associated with slippery ovulation prediction products. surfaces, and is completely safe to use NEBA Health LLC and represents no health hazard. Boulder Oval Window Audio www.nebahealth.com Nederland Micro Imaging Solutions, LLC (MIS) Develops neuropsychiatric medical www.ovalwindowaudio.com Denver devices, such as Neba™ an experimental, Produces induction loop assistive listening www.micro-imaging.us small format EEG-based device. systems and visual and vibrotactile technologies Developed an innovative-patented technol- that help deaf and hard-of-hearing individuals. ogy that can be utilized in the manufacture C Neuro Assessment Systems of micro-digital CMOS cameras. Littleton Paré Surgical, Inc. www.neuroassessments.com Centennial Microlife Medical Home Solutions, Inc. Provides an objective brain-based measure www.paresurgical.com Golden of neurocognitive symptoms associated with Develops surgical instruments such as the www.mimhs.com a wide range of brain health issues including Quik-Stitch endoscopic suturing system. Hand-held medical devices and systemic solutions concussion and Alzheimer’s disease. offer healthcare providers evidence-based methods Parker Medical for accurate assessment, diagnosis and treatment C Neuromonics, Inc. Highlands Ranch of cardiovascular and metabolic diseases. Westminster www.parkermedical.com www.neuromonics.com Provides airway management products Manufacturers and distributes clinically proven that make intubation safer for the patient devices to treat tinnitus. Products include the and easier for the medical professional. Oasis, Haven and Sanctuary helping tinnitus sufferers improve their quality of life.

46 BIOSCIENCE COLORADO 2015-2016 C = CBSA MEMBER

PCC/Advanced Forming Technology Precision Glassblowing Radiological Imaging Technology, Inc Longmont Centennial Colorado Springs www.aftmim.com www.precisionglassblowing.com www.radimage.com Medical device component product Provides custom and OEM scientific glass for Provides clinical and research physicists development and manufacturing with custom synthesis, pharmaceutical, environ- with a high-precision automated QA tool metal injection molding expertise. mental, petrochemical, research, commercial, for advanced radiation therapies. government and medical laboratories. Peak Robotics, Inc. Rand-Scot, Inc. Colorado Springs Preferred Medical Products, Inc. Fort Collins www.peakrobotics.com Englewood www.randscot.com Manufactures robots, special equipment, www.preferredmedicalproducts.com Designs and manufactures products for persons and turnkey automated systems. Manufactures stainless steel medical components with disabilities, including BBD Cushions for hypodermic needles and lancet type products. and Mattress Overlays, EasyPivot Patient Peddle Master, Inc. Lifts, and Saratoga Exercise Products. Johnstown C Prima-Temp, Inc www.peddlemaster.com Boulder Rapid Prototying Corporation Designs and manufactures handicapped driving www.prima-temp.com Longmont aids. The Peddel Master is totally portable and can Innovative biometric approaches to early disease www.rapidpro.com be installed and removed in a matter of seconds. detection and reproductive medicine through Offers engineering, design and other manufac- the application of 21st Century thermometry. turing services for the medical device industry. Pernicka Corporation Fort Collins Products Group International, Inc. Research Electro-Optics www.pernicka.com Lyons Boulder Offers analytical testing that meets or exceeds the www.productsgroup.com www.reoinc.com requirements of MIL-STD 750/883 method 1018 and Researches, develops and engineers ultra- Volume manufacturer of high-precision thin film 45662A for companies in the aerospace, basic & ap- sound medical and veterinary equipment. coatings, optics and optomechanical assemblies plied research, surface analysis, thin film deposition, for the ultraviolet through the long-wave infrared. laser technology and medical products industries. Propel Labs, Inc. Fort Collins Rocky Mountain Instrument Company (RMI) C PharmaJet, Inc. www.propel-labs.com Lafayette Golden Designing the next generation of bio-instru- www.rmico.com www.pharmajet.com mentation tools. Focused on research tools, Designs and manufactures optics and coatings Develops a needle-free technology that has a such as single cell analyzers and cell sorters. (ultraviolet through far infrared) for the low-cost, single-use, disposable polypropylene vial or medical industry. cartridge, suitable for the delivery of common vaccines ProTechSure Scientific, Inc and standard dose injectable liquid medicines. Aurora Rocky Mountain Orthodontics, Inc. (RMO) ProTechSure Scientific, Inc. is a company dedicated Denver C Phase Three Product Development to providing scientifically validated skin protection. www.rmortho.com Fort Collins Serves all areas of orthodontics, including pediat- www.phasethreedev.com Protomed, Inc. ric orthodontic prevention, interceptive pediatric Technology and product development of Denver orthodontics, mixed dentition orthodontics, adult microfluidics-based devices and systems. www.protomed.net orthodontics, reconstructive dentistry orthodon- Creates accurate anatomical models tics, TMJ orthodontics, surgical orthodontics and PolyNEW, Inc. from CT scans by using the latest imaging breathing/sleep problem-related orthodontics. Aurora software and laser driven technology. Developed a new class of PLA bioplastics, or RxAssurance “ecobionanocomposites,” that are nanocomposites Prototype Casting, Inc. Boulder from 100 percent renewable resources. They Denver www.rxassurance.com exhibit high heat resistance and clarity at a low cost. www.protcast.com User-friendly, patient feedback system to PolyNEW is commercializing a series of bioplastic Manufactures non-ferrous prototype parts collect, analyze and report data related to formulations in the form of industry standard for the medical industry, specializing in medication adherence, effectiveness, safety, pellets that could be used in a wide variety of RPM (Rubber Plaster Mold) casting, sand satisfaction and patient continuity of care. applications, including medical device applications. casting and rapid-investment casting. RxAssurance blends today’s technology and effective behavioral motivators to engage Porta-Lung, Inc. PTA Corporation patients after they have received care, been Lakewood Longmont prescribed medication, or been discharged from www.portalung.com www.ptacorp.com their provider, to report their experiences. Provides non-invasive ventilator support for Manufactures aluminum and steel molds long-term patients who need more portability. for projects with lifetime runs of 5,000 to C Samson Design Associates, Inc. 250,000 pieces for medical applications. Boulder Precision Biopsy www.samsondesign.com Aurora C Purewater Medical Inc. Provides full-service product development ranging www.alliedminds.com/subsidiaries/precision-biopsy Longmont from concept to production specifications, In partnership with Allied Minds, developing www.purewater-medical.com with many products for the medical field. technology for the accurate diagnosis of prostate Develops products and technologies that cancer which uses advanced spectroscopy imaging simplify the delivery of medical fluids. techniques in combination with tissue biopsy. 2015-2016 BIOSCIENCE COLORADO 47 Sandhill Scientific C Shippert Medical Technologies Sontec Instruments, Inc Highlands Ranch Centennial Centennial www.sandhillsci.com www.shippertmedical.com www.sontecinstruments.com Designs, manufactures and distributes diagnostic Manufactures and distributes medical Provides a broad line of instruments as products focused on gastroenterology. disposable products and instruments. well as custom instrument manufacturing and in-house repair service. Sapien LLC Sinopsys Surgical Fort Collins Boulder C Sophono, Inc. www.sapienllc.com www.sinopsyssurgical.com Boulder Aims to enhance the human experience by Proprietary Lacrimal Sinus Diversion offers www.sophono.com providing innovative solutions to human problems functional therapy for sufferers of chronic Developed the world’s first non-percutaneous, using sensory substitution, human-machine sinusitis with minimal response to current implantable bone anchored hearing device. interfaces, and human-machine integration. pharmaceutical and surgical options. C Sorin Group Sartorius TCC (formerly Denver SI-Technology, LLC Arvada Instrument Company) Fort Collins www.sorin.com Arvada www.si-technology.co Global medical device company and a leader www.sartorius.us Orthopedic medical device company currently in the treatment of cardiovascular diseases. Designs and manufacturers analytical developing new techniques and implants as part balances, electrochemistry instruments, of the patent pending SI-DESIS™ Sacroiliac Joint Sound Surgical Technologies, moisture analyzers, and titration controllers. Implant System to help assist physicians address LLC/Solta Medical, Inc. the need for treatment, fixation and proper fusion Louisville Science Care of painful and dysfunctional sacroiliac joints (SIJ). www.vaser.com Denver Offers ultrasonic technologies and related www.sciencecare.com Siva Therapeutics Inc techniques for aesthetic surgery. Provide human tissue for medical research and Boulder education. We serve as a link between individual www.sivatherapeutics.com Sparton donors and medical researchers and educators. Commercializing a proprietary therapeutic Frederick device technology, based on gold nanorods, www.sparton.com Scientech, Inc. that can be used both independently and in Leading contract manufacturer of low to medium Boulder conjunction with existing and new cancer drugs. volume, complex products for the medical device, www.scientech-inc.com biotech and industrial instrumentation markets. Manufactures analytical instruments: semi-micro bal- C Snoasis Medical ances, analytical balances, semi-analytical balances, Denver C Spectranetics Corporation and toploading balances for the medical industry. www.snoasismedical.com Colorado Springs Focused on the development and commer- www.spectranetics.com Sealcon cialization of regenerative tissue and medical Develops, manufactures, markets and distributes Centennial device products for use in dental surgery. single-use medical devices used in minimally inva- www.sealconusa.com sive procedures within the cardiovascular system. Manufactures cable-management components, C Soma Access Systems including liquid tight strain relief fittings, Englewood ST Cardio Technologies, LLC flexible conduit, M23 circular connectors and www.somaaccesssystems.com Broomfield related products for the health care industry. Focused on designing, developing, and commer- www.stcardio.com cializing unique, cost-effective solutions for prob- Designs, develops, and manufactures C Securisyn Medical lems arising during specific medical procedures. electronic medical devices for use in Highlands Ranch electrophysiology cardiac cath labs. www.securisyn.com C SomaLogic, Inc. Dedicated to a continuous process of increasing Boulder C St. Renatus, LLC the safety and effectiveness of our unique www.somalogic.com Fort Collins life-saving product, which is utilized by skilled Uses aptamer array technology and bioinfor- www.st-renatus.com medical practitioners to deliver the highest quality matics capabilities to discover disease-specific First needle-free, dental anesthetic suitable emergency and intensive care to their patients. biomarkers and protein signatures. Develops for use in procedures involving most of the medical diagnostics based on these signatures. upper teeth. Uses an accurate and sophisti- Shape Ophthalmics LLC cated method to anesthetize the upper teeth Aurora Sonaura without the risk and pain of a needle. Develops state-of-the-art devices and novel Fort Collins treatments for ophthalmic conditions through www.mysonaura.com StnDrd Infusion the application of advanced smart materials. Sonaura is an electronic two-way com- Parker munication system between patient and www.stndrdinfusion.com C Sharklet Technologies, Inc. doctor, and represents a major advance in Early-stage medical device company in the Aurora IVF treatment allowing women undergoing drug-infusion market with a standardized www.sharklet.com IVF treatment to perform their sonograms at pump capable of performing the product Engineers surface technologies (Sharklet™) that home during the follicle stimulation cycle. requirements currently met by syringe, cassette, control the growth of dangerous bacteria. and ambulatory pump configurations.

48 BIOSCIENCE COLORADO 2015-2016 C = CBSA MEMBER

C Strand Genomics Inc. Tapeless Wound Care Products, LLC Transtracheal Systems, Inc. Aurora Englewood Englewood www.strandls.com www.tapelesswoundcare.com www.tto2.com Strand Genomics is a global clinical genomics and Manufactures and distributes a system of patented Develops and manufactures innovative bioinformatics company with three business verti- secondary wound dressing retention devices, respiratory therapy products that advance cals, including Research Software products, Biophar- offering an alternative to traditional secondary medical therapy for persons requiring continuous ma services and Personalized Medicine. Strand Ge- wound dressings, for both humans and animals. supplemental oxygen, including the SCOOP nomics is the U.S subsidiary of Strand Life Sciences. transtracheal oxygen therapy system. Tartan Orthopedics, Ltd C Subwave Sensing Northglenn C Transverse Medical Inc. Aurora www.tartanortho.com Evergreen www.subwavesensing.com Manufactures sacro lumbar belts, dorsal www.transversemedical.com The future of fracture care giving the orthopaedic lumbar belts (corsets and moldable inserts), Developing the POINT-GUARD ™ Embolic hardware market an infusion of intelligence. Ottenberg style elbow splints, pelvic traction Protection System for cerebral and distal embolic belts, arm slings, cervical collars, acromio- protection during cardiovascular percutaneous Sundance Diagnostics, Inc. clavicular splints and ankle supports. interventions and surgical procedures. Boulder www.sundancedx.com TDA Research, Inc. TRS, Inc. Working to develop the world’s first genetic Wheat Ridge, Golden Boulder safety tests to predict a patient’s risk of www.tda.com www.trsprosthetics.com antidepressant-induced suicidal thinking Provides automated catalyst testing equipment to Develops, manufactures, and markets or behavior. large chemical companies and national laboratories. body-powered prosthetic devices. Designs and builds technology for persons missing hands. Sunrise Medical Inc. Tech-X Corporation Longmont Boulder Ultrathera Technologies, Inc. www.sunrisemedical.com www.txcorp.com Colorado Springs Provides home healthcare products, including Specializes in scientific and engineering software, www.ultrathera.com wheelchairs, respiratory, daily living aids including visualization and algorithm development. Applying advanced technologies to and speech augmentation devices. physiological and neurological needs. TeraBAT Maker of AeroStim™ and PointScribe™. Supreme Cable Technologies, Inc. Longmont Denver www.terabat.com C Value Plastics, Inc. www.supremecable.com Developing a disruptive detection platform Fort Collins Manufactures quality custom cable based on terawaves technologies that will www.valueplastics.com assemblies and wire harnesses. revolutionize disease diagnosis and patient care. Designs and manufactures plastic tubing fittings and connectors. C Surefire Medical Inc. C Terumo BCT Westminster Lakewood C ValveXchange, Inc. www.surefiremedical.com www.terumobct.com Greenwood Village Developing a novel infusion system for A global leader in blood component and cellular www.valvexchange.com the interventional radiology market. technologies, is the only company with the unique Develops a bioprosthetic heart valve with a percu- combination of apheresis collections, manual and taneously-exchangeable leaflet set that provides SurgiReal Products automated whole blood processing, and pathogen lifetime service without anti-coagulation therapy. Fort Collins reduction coupled with leading technologies www.surgireal.com in therapeutic apheresis and cell processing. C Veramarx Inc. Creates and introduces innovative products Aurora and methods for use in surgical training. TheraTogs, Inc. www.veramarx.com Telluride Focus to become the leading provider of C Swan Valley Medical, Inc. www.theratogs.com credible clinical and scientific information, Aurora Produces an orthotic undergarment and reliable and accurate diagnostic tools and www.swanvalleymedical.com strapping system that gives clients with effective treatment options for Lyme disease. Developed a line of urology instruments that sensorimotor impairment a new modality for allow for safer, faster and more economical improving postural alignment and stability. Vista LifeSciences treatment of common urological disorders. Parker C Tissue Fusion, LLC www.vistalifesciences.com Synergy Health Americas Colorado Springs Innovative healthcare technology solutions Denver www.tissuefusion.com for global healthcare challenges. www.synergyhealthplc.com Laser-based medical devices to fuse biological tissue Offers electron beam sterilization for together as an alternative to sutures or staples. WalkMed Infusion, LLC medical and pharmaceutical devices. Englewood Touch of Life Technologies, Inc. (ToLTech) www.walkmed.net Aurora Offers solutions for ambulatory infusion www.toltech.net therapy and pain management. Develops procedural simulators in the areas of ortho- paedics, gastroenterology, rheumatology, radiology, ophthalmology and general surgical procedures. 2015-2016 BIOSCIENCE COLORADO 49 Wi LLC Agripro COKER C AnImmune LLC Englewood Berthoud Golden www.wiinc.net www.agriprowheat.com Infectious disease-centric company focused Designs and engineers medical devices. Including Develops and delivers superior wheat on enhancing efficacy of animal vaccines innovative services such as laser welding, seed genetics in North America. using knowledge accumulated through de- assay design and air bubble management. cades of human vaccine technology. AKTIV-DRY Ximedix, Inc. Boulder C AntriaBio Colorado Springs www.aktiv-dry.com Denver www.ximedix.com Provides dry powder processing solutions for the vac- www.antriabio.com Manufactures and sells single patient use medical cine, pharmaceutical and biotechnology industries. Lead diabetes product candidate, AB101, is a once- products for the anesthesia, respiratory care, a-week injectable basal insulin that is currently in critical care and emergency medicine applications. Allergan, Inc. preclinical development. AB101 is administered Highlands Ranch by subcutaneous injection and targets patients Yamato Corporation www.allergan.com with type 1 and type 2 diabetes who require Colorado Springs Multi-specialty health care company focused on basal insulin for the control of hyperglycemia. www.yamatocorp.com discovering, developing and commercializing Manufactures and sells weighing equipment innovative pharmaceuticals, biologics, medical C ApopLogic Pharmaceuticals, LLC and systems for medical facilities. devices and over-the-counter consumer products. Aurora www.apoplogic.com Zynex Medical, Inc. American Allied Biochemical, Inc. Focused on the development and commercial- Lone Tree Aurora ization of Breceptin, a unique oncolytic drug for www.zynexmed.com www.aablabs.com the treatment of a wide range of solid tumors. Offers electrotherapy products, utilizing Specializes in the purification and distribution various methods of non-invasive muscle of restriction endonucleases enzymes. Aquatic BioSystems stimulation and electromyography technology, Fort Collins Interferential Current (IFC) and Transcutaneous C Amgen, Inc. www.aquaticbiosystems.com Electrical Nerve Stimulation (TENS). Boulder, Longmont Full-service organism culturing facility specializing www.amgen.com in the production and distribution of freshwater Discovers, develops, manufactures and and marine organisms for aquatic toxicology, markets human therapeutics based on biomonitoring and other research activities. BIOTECHNOLOGY, PHARMA advances in cellular and molecular biology. ARCA biopharma, Inc. AND RELATED COMPANIES C AmideBio, LLC Broomfield, Aurora Boulder www.arcabiopharma.com Accera, Inc. www.amidebio.com Specializes in developing and commercial- Broomfield Focused on providing peptide and protein izing genetically-targeted therapies for heart www.accerapharma.com research reagents and clinical products for a failure and other cardiovascular diseases. Developed Axona, the first proprietary commer- diverse array of research and commercial targets cialized Alzheimer’s disease therapy that addresses using proprietary Biopure-Process™ technology. C Array BioPharma the well recognized physiological hallmark and Boulder, Longmont metabolic defect of hypometabolism, the brain’s C Ampio Pharmaceuticals, Inc. www.arraybiopharma.com inability to optimally metabolize glucose. Greenwood Village Discovers, develops and commercializes targeted www.ampiopharma.com small molecule drugs to treat debilitating and ADA Technologies, Inc. Development stage biopharmaceutical life-threatening diseases such as cancer. Littleton company focused on the discovery and www.adatech.com development of novel therapies aimed at C Atlas Biologicals, Inc. Development and commercialization treating common inflammatory conditions. Fort Collins of innovative technologies. www.atlasbio.com Anabolic Laboratories Manufactures, markets and distributes Advanced Regenerative Therapies (ART) Colorado Springs animal sera and cell culture reagents. Fort Collins www.anaboliclabs.com www.art4dvm.com Focused line of nutritional products, with Aurogen Provides a stem cell isolation and expan- state-of-the-art pharmaceutical manufacturing Fort Collins sion service for veterinary medicine. facilities in California and Colorado. www.aurogen.com Produces a pharmaceutical treatment for diabetic Agilent Nucleic Acid Solutions Animal Health Options neuropathy, with a second invention showing Boulder Golden that neurotrophic hormones can act across the www.agilent.com www.animalhealthoptions.com blood-brain barrier to treat various brain disorders. Develops and manufactures ther- Animal Health Options has been offering high-qual- apeutic oligonucleotide. ity antioxidants and nutritional supplements that meet or exceed industry standards and provide a noticeable benefit to dogs, cats and horses.

50 BIOSCIENCE COLORADO 2015-2016 C = CBSA MEMBER

Aurora Oncology C CariCord C Clovis Oncology, Inc. Aurora Aurora Boulder Researching DT-EGF Toxic Fusion Protein www.caricord.com www.clovisoncology.com for treatment of bladder cancer. Our mission is to provide parents with the Focused on acquiring, developing and commer- confidence that they have taken the right cializing innovative anti-cancer agents in the US, C Avidity, LLC steps to protect their children’s future by Europe and additional international markets. Aurora securing the finest processing and storage www.avidity.com of umbilical cord blood and stem cell Colorado Biolabs, Inc. Develops and sells molecular affinity products available anywhere in the world. Frederick tools for connecting molecules. www.proferrin.com C CBL (Chemical and Biopharma- Colorado Biolabs, Inc., the manufacturer of C Biologistics Medical ceutical Laboratories) Proferrin® ES and Proferrin® Forte, an oral iron sup- Class 2a/2b and 3 medical device development. Boulder plement made from heme iron polypeptide (HIP). www.cblbiopharma.com BioResponse, LLC Offering peptide starting-materials, peptide Colorado Genetics, Inc. Boulder intermediates, and industrial- and commer- Loveland www.bioresponse.com cial-scale manufacturing of proprietary and www.coloradogenetics.com Researches, develops and commercializes generic GMP and non-GMP peptides. Provides livestock embryo-transfer dietary supplements for better absorption and research, artificial insemination, embryo functional foods. Cell>Point collection, freezing and transfer, and Centennial international import and export services. BioServe Space Technologies www.cellpointweb.com Boulder Develops novel radiopharmaceutical imaging C Colorado Histo-Prep (CH-P) www.colorado.edu/engineering/BioServe agents, radiotherapeutic agents and local regional Fort Collins Researches space life science with a wide range radio/chemotherapeutic drug delivery systems www.histoprep.com of biotechnology applications involving animals, for the diagnosis, treatment and post-therapy Produces high-quality slides, clinical chemistry plants and microorganisms. Specializes in asessment of cancer, cardiovascular disease, and hematology data and fully integrated conducting microgravity life science research and infectious disease and metabolic diseases. and detailed seamless pathology reports. designing and developing space flight hardware. Cetya Therapeutics, Inc. Colorado Serum Company Biosyntrx Inc. Fort Collins Denver Colorado Springs www.cetyatherapeutics.com www.colorado-serum.com www.biosyntrx.com Founded to commercialize analogs of the class Supplies veterinary biologic vaccines, Develops nutraceuticals to address the I isoform selective histone deacetylase inhibitor instruments, laboratory reagents and micronutrient needs of the dry eye, cat- (HDACi) largazole, targeting unmet medical needs, serums for the veterinary industry. aract, macular degeneration, glaucoma especially in oncology, neurodegeneration, and diabetic retinopathy patient. autoimmunity and hemoglobinopathies. Corden Pharma Boulder Bolder BioTechnology, Inc. Cévan International, Inc. www.cordenpharmacolorado.com Boulder Longmont Corden Pharma Colorado is the small- to www.bolderbio.com www.cevan.com large-scale resource for peptides manufacturing. Uses advanced protein engineering technologies Delivers vitamins, minerals and botanical to create proprietary human protein pharmaceu- extracts as well as specialty nutriceutical C Crestone, Inc. ticals with enhanced therapeutic properties. formulations and antioxidants. Boulder www.crestonepharma.com Boulder Scientific Company C CHATA Biosystems Drug discovery and development company Mead Fort Collins focused on developing novel treatments www.bouldersci.com www.chatasolutions.com for serious bacterial infections. Provides organometallic compounds Manufactures blended reagents, HPLC mobile to the pharmaceutical, polymer, and phases, standards, buffers and dissolution media. C Cytoskeleton, Inc. specialty chemical industries. Denver C CHD Bioscience, Inc. www.cytoskeleton.com Cargill Research Fort Collins Offers kits for drug screening, signal transduction Fort Collins www.chdbioscience.com and cytoskeletal research specializing in the www.cargill.com Advancing patient care through the creation production of purified proteins and easy-to-use Develops, processes and markets science-based, of novel antimicrobials for the prevention kits to study biochemical and cellular processes. health-promoting ingredients for food and and treatment of infectious disease. dietary supplement industries worldwide. DaVita Clinical Research (DCR) C ClinImmune Labs Denver Aurora www.davitaclinicalresearch.com www.clinimmune.com Offers a complete array of early-phase Comprises five laboratories to provide services to study capabilities through its two kidney, heart, lung, pancreas and hematopoietic state-of-the-art research facilities. stem cell transplant programs around the world.

2015-2016 BIOSCIENCE COLORADO 51 C ELISA Tech Genesis Laboratories, Inc. C HemoGenix Aurora Wellington Colorado Springs www.elisatech.com www.genesislabs.com www.hemogenix.com Provides immunoassays for the measurement Provides services to clients in the agrochemical and Private contract research service and assay of cytokines, growth factors, and lipid pharmaceutical industries, rodenticide research development laboratory specializing in inflammatory mediators. and development, as well as invasive species, developing predictive in vitro assay platforms zoonotic disease, and conservation research. for primary human and animal target cells Entero Track and stem cell hemotoxicity testing. Centennial GeneThera, Inc. Next-generation monitoring of gastrointestinal Westminster C HepQuant, LLC allergic diseases. www.genethera.net Aurora Develops and markets the latest molecular www.hepquant.com C Evolutionary Genomics (EG) technologies to eradicate “cross over” diseases, Designed test parameters using continuous Lafayette such as Johne’s Disease, Mad Cow Disease, variables that may be correlated to clinical features www.evolgen.com Chronic Wasting Disease, and E.coli. Develops or may be followed over time to measure disease Identifies genes with a high likelihood of assay tests and vaccines to eradicate the progression. HepQuant-E is non-invasive, uses commercial value for downstream validation threat to humans of diseases transmitted stable (not radioactive) isotopes, and relies on through its proprietary Adapted Traits platform. up the food chain by cattle, elk and deer. natural, well-defined hepatic functions to measure the portal circulation. C Flagship Biosciences C GlaxoSmithKline Boulder Denver Heska Corporation www.flagshipbio.com www.gsk.com Loveland Oncology drug development and tissue Produces medicines that treat six major disease www.heska.com analytics and pathology services. areas – asthma, virus control, infections, mental Develops advanced diagnostics and health, diabetes and digestive conditions as well specialty products for veterinary practices C FluoroFinder LLC as vaccines and new treatments for cancer. that focus on companion animals. Broomfield www.fluorofinder.com C GlobeImmune, Inc. Hiberna Corporation Software as a Service (SaaS) experiment Louisville Boulder design tool for flow cytometry that dramatically www.globeimmune.com Pursuing the potential clinical application of improves a medical researcher’s productivity Discovers, develops and manufactures potent, hibernation in order to slow metabolism, thereby and quality while reducing costs. targeted molecular immunotherapies called extending survival limits in traumas that reduce Tarmogens, targeted antigens that distinguish oxygen to certain cells, e.g. in the heart and brain. C FluTrends International/ STS Health diseased cells from normal cells, for the Denver, Aurora treatment of cancer and infectious diseases. C Hospira, Inc. www.stshealth.com Boulder Biotechnology company that plans to Great Lakes Pharmaceuticals www.hospira.com develop and commercialize products Denver Supplies injectable generic and specialty for the prevention of influenza. www.glpharma.com pharmaceuticals. The Colorado site specializes in Development leading to commercialization the supply of active pharmaceutical ingredients C Gates Biomanufacturing Facility of innovative, effective product for prevention for both internal and external markets. Aurora of catheter-related microbial infections www.ucdenver.edu/academics/colleges/medical- in clinical and in outpatient settings C i2 Pharmaceuticals, Inc. school/centers/StemCell/Pages/StemCell.aspx Boulder Good Manufacturing Practices Facility FDA Greffex, Inc./ Isogenis, Inc. i2 Pharm produces drug discovery services to approved for production of biologicals from Aurora pharmaceutical companies. Using a variety of Cell Culture and microbial fermentation www.greffex.com technologies, i2 creates tools for pharmaceutical suitable for early clinical trials in humans. Develops and produces new therapeutics drug discovery and development; in addition to for immune suppression in humans to proprietary medicinal chemistry services for the Gene Check, Inc. prevent transplant rejection, improve gene expansion of intellectual property protection of Greeley therapy and develop novel approaches to early- and late-stage pharmaceutical assets. www.genecheck.com the treatment of autoimmune diseases. Gene Check is a diagnostic laboratory specializing imuTek Laboratories, Inc. in veterinary genetics. In addition, Gene Check Hauser Laboratories, Division of Microbac Fort Collins maintains a dynamic biotech research program, Boulder www.imutek.com including rare DNA sequence and SNP detection. www.hauserlabs.com Develops and markets bovine colostrums for Provides research, development, and testing to the nutrition and health products industry. The C Genentech the pharmaceutical, natural products, dietary first manufacturer to receive an indication for Denver supplement and medical device industries. colostrum for the passive transfer of antibodies www.gene.com (immunoglobulins) in dry powder form. Using human genetic information to discover, develop, manufacture and commercialize C Invenux LLC medicines to treat patients with serious or Windsor life-threatening medical conditions. Pharmaceutical research and development for orphan diseases.

52 BIOSCIENCE COLORADO 2015-2016 C = CBSA MEMBER

InVitria Legacy BioDesign, LLC C Merck & Co., Inc. Fort Collins Johnstown Denver www.invitria.com www.LegacyBioDesign.com www.merck.com InVitria develops, manufactures and markets Conducts peptide and protein formulation Merck and Co. produces products that cover a portfolio of high-performance and well and assay development work for biopharma a broad range of areas, including heart and defined cell culture products and reagents companies. The company also specializes respiratory health, infectious diseases, sun used in bioprocessing, biopharmaceutical in drug delivery and process development care and women’s health. It focuses its formulation, stem cell and regenerative med- of biotechnology-based products. research on conditions that affect millions icine, life science research and diagnostics. of people around the world – diseases like C Lohocla Research Corporation Alzheimer’s, diabetes and cancer – while JHPIEGO-Denver Aurora building strengths in new areas like biologics. Aurora www.lohocla.com Designing and implementing effective, low-cost Research and development company that is C MicroBiome Therapeutics, LLC technologies – first product aimed at improving at the forefront of discovery of medications Broomfield the management of postpartum hemorrhage. for chronic pain, addictive and other mental www.mbiome.com health and neurological disorders. Clinical stage biotechnology company developing C Johnson & Johnson pharmaceutical and medical food products Denver LUCA Lifesciences that aim to improve health status by interacting www.jnj.com Boulder with and altering the human microbiome. Manufactures a broad selection of health www.lucalifesciences.com care products, as well as a provider of related Utilizes in-plant technology to increase the value MicroChemica, LLC services, for the consumer, pharmaceutical and of the hemp plant. Applications for industrial Fort Collins medical devices and diagnostics markets. grade plastics, textiles and medical devices. Company is focused on environmental remediation using on-line systems C KBI Biopharma C MBC Pharma, Inc. and portable units for analysis. Boulder Aurora www.kbibiopharma.com www.mbcpharma.com C miRagen Therapeutics World class biopharmaceutical CMO/CDMO Biopharmaceutical company focused on Boulder services organization. discovering and developing drugs for bone www.miragentherapeutics.com diseases, such as cancer and osteoporosis. Improves patients’ lives by developing innovative Keeton Industries, Inc. microRNA- (miRNA) based therapeutics for the Wellington C MedImmune, LLC, subsidiary of AstraZeneca treatment of cardiovascular and muscle disease. www.keetonaqua.com Denver Researches and develops biological water www.medimmune.com Molecular BioSciences, Inc. treatment, aeration, ozone aeration, solids removal, Develops medicines for unmet medi- Boulder biofiltration and other new technologies. cal needs worldwide. Industry leader www.molbio.com in personalized medicines. Manufactures products such as water soluble Kimball Genetics, Inc. biotinylation reagents, vitamin derivatives, Denver Mediral International, Inc. crosslinking reagents, lipophilic probes, www.kimballgenetics.com Denver fluorophores, radioiodination reagents and Genetic testing laboratory specializing in www.mediral.com dendritic cores for preparing oligomers. DNA analysis for common genetic disorders Develops, manufactures and sells homeopathic that are preventable or can be treated. pharmaceuticals, taking into consideration antidotes. MonImmune Therapeutics Fort Collins C KromaTid, Inc. Membrane Protective Technologies Inc. Developing a pipeline of repurposed compounds fo- Fort Collins Fort Collins cused on monocyte regulation as vaccine adjuvants. www.kromatid.com www.membrane-protect.com Develops a method and kit using chromatid paints Blend of organic plant extracts that improves C Monsanto Company to improve detection of chromosomal inversions. artificial insemination pregnancy rates in cows. Englewood The improvement is important to medical www.monsanto.com applications such as cancer and birth defects. C MenoGeniX Leading global provider of technology-based Aurora solutions and agricultural products that C LABS, Inc. www.menogenix.com improve farm productivity and food quality. Denver Clinical stage biotech company developing www.labs-inc.org MNGX-100, a therapeutic biologic, as a novel, C Montana Molecular Provides laboratory testing services focused on non-hormonal, non-SSRI/SNRI, alternative to treat Bozeman, MT donor eligibility determination and final product hot flashes and related vasomotor symptoms in www.montanamolecular.com safety; infectious disease, microbiology, histo- women with natural or surgically-induced meno- Fluorescent technologies for drug compatibility and environmental monitoring. pause. In 2014, MenoGeniX completed a Phase discovery in living cells. lb/lla clinical trial and is using the data to design additional phase ll/lll trials leading to registration.

2015-2016 BIOSCIENCE COLORADO 53 C Mosaic Biosciences C Omni Bio Pharmaceutical, Inc. C Pfizer Pharmaceutical Company Denver, Aurora Greenwood Village Centennial www.mosaicbio.com www.omnibiopharma.com www.pfizer.com Start-up company focused on the In preclinical development of a recombinant Discovers, develops, manufactures, and markets development of innovative materials form of alpha-1 antitrypsin (“AAT”). prescription medicines for humans and animals. for tissue regeneration and repair. C OncoInnovations PhosphoSolutions, LLC C Nanoly Bioscience, Inc. Boulder Aurora Denver www.phosphosolutions.com www.nanoly.info OncoTherix Designs and produces phosphoproteins solutions Developing a safe and proprietary polymer Aurora using phosphor-specific antibodies. Phosphoproteins encapsulation to stabilize and protect www.oncotherix.com are thought to be critical elements in neurological therapeutic biological molecules, such as Clinical-stage oncology company focused on the diseases, such as Alzheimer’s, and in cancer. vaccines and enzymes, from below freezing development of InCell-RT (Intracellular radio- to beyond tropical room temperatures. therapy) for the treatment of locally advanced Pisces Molecular cancers (LACs). InCell-RT is a unique, DNA-ligated, Boulder C NanoSphere Health Sciences nanometer-scale intracellular radiotherapy with www.pisces-molecular.com Greenwood Village the potential to selectively kill cancer cells without Focused on applying molecular genetics www.nanospherehealth.com causing damage to surrounding healthy tissue and technology to problems of fisheries Emerging biotech company that has created without the development of treatment resistance. and aquatic conservation biology. an advanced delivery system platform of new products. We are changing the way C OPX Biotechnologies Plura Biosciences Inc. people take and benefit from nutraceu- Boulder Lafayette tical supplements and medications. www.opxbiotechnologies.com www.plurabioscience.com Technology platform enables rapid, rational, and Specialized catalysts and chemicals that C Nivalis Therapeutics, Inc. robust optimization of microbes and bioprocesses enable highly efficient, cost-effective and Boulder to manufacture bioproducts with equivalent green-chemistry solutions in the manufac- www.n30pharma.com performance and improved sustainability at lower ture of important life science products. Drugs that target nitric oxide reductase (NOR), cost compared to petroleum-based alternatives. the most important of which is s-nitrosogluta- C Pyxant Labs Inc. thione reductase (GSNOR) an enzyme of central Pambec Laboratories, Inc. Colorado Springs importance in human health and disease. Loveland www.pyxant.com Researches drug discoveries in the field of AIDS. Provides GLP regulatory bioanalytical support C Novartis Pharmaceuticals Corporation for non-clinical through clinical development Broomfield Pathways Bioscience, Inc. programs. Specialties include rare tissues, www.novartis.com Aurora RNA and oligonucleotide therapeutics, Researches and develops products to Early-stage bioscience company focused nucleoside antivirals, and agricultural and protect and improve health and well-being on discovering and developing new industrial biotech applications. with core businesses in pharmaceuticals, agents for modifying gene expression and vaccines, consumer health, generics, regulating stressresponse pathways that Quark Pharmaceuticals, Inc. eye care and animal health. contribute to cell-defense mechanisms. Boulder www.quarkpharma.com C Novus Biologicals, Inc. Peak Analytical, Inc. Discovers and develops siRNA drug candidates Littleton Golden for treating age-related macular degeneration www.novusbio.com www.peaklab.net and prevention of acute renal failure. Develops, tests and markets antibodies for Specializes in materials and chemical analysis. research of human diseases such as cancer, Performs a variety of molecular- and atomic- Quicksilver Scientific cardiovascular and neurological disorders. level spectroscopic techniques to Lafayette identify failures and defects. www.quicksilverscientific.com C Nutrinsic Inc. Clinical and environmental mercury lab Aurora Peak Pharmaceuticals, Inc. and dietary supplement manufacturing. www.nutrinsic.com Aurora Early-stage company with proprietary tech- www.peakpharma.com Recreo Pharma nology capable of producing a cost-effective, Peak Pharmaceuticals, Inc. specializes in Aurora sustainably produced protein meal. Product the development, manufacturing, sales and Resistance-modifying agents to combat serves as a fish meal replacement (FMR) or marketing of pharmaceutical-grade, hemp- antibiotic resistance. additive ingredient for animal feeds, primarily based nutraceutical and supplement products those destined for the aquaculture industry. for the human and animal health markets. Regenerative Sciences Inc. Broomfield Ocugen PeptiVir www.regenexx.com Aurora Aurora Advances stem cell therapies through devel- www.ocugen.com www.site.peptivir.com opment of Regenexx™, an injection procedure Novel biotherapeutics to treat eye diseases. PeptiVir is an early-stage biopharmaceutical to treat a wide variety of painful conditions. company focused on the development and commercialization of a conformationally constrained, synthetic peptide-based vaccine 54 BIOSCIENCE COLORADO 2015-2016 platform for the prevention of viral diseases. C = CBSA MEMBER

C Rocky Mountain Biosystems, Inc. C Sudhin Biopharma Company UBPBio Wheat Ridge Superior Aurora Research and development of transdermal www.sudhinbio.com www.ubpbio.com pharmaceuticals and delivery systems, Developing compact cell settlers to remove dead Manufactures and sells bioreagents related cosmetic devices, and tissue adhesives. cells and cell debris selectively from high cell to the ubiquitin-proteasome pathway. density perfusion bioreactors. Demonstrating Rocky Mountain Diagnostics, Inc. the effectiveness of selective dead cell removal C UCB, Inc. Colorado Springs with the smaller microbial yeast secretory Brussels, Belgium www.rmdiagnostics.com expression systems, as it has proven successful www.ucb.com Provides immunodiagnostic assays and with mammalian cells at the commercial scale. Global biopharma focused on severe diseases reagents for biogenic amines, research with operations in approximately 40 countries . reagents, a CLIA-certified reference laboratory Summit Plant Laboratories, Inc. and contract manufacturing services. Fort Collins Upsher-Smith Laboratories, Inc. www.plantlabs.com Denver Rocky Mountain Instrumental Laboratories Applies laboratory plant cloning and greenhouse www.upsher-smith.com Fort Collins technologies to produce planting stocks for Develops, manufactures and markets a vast www.rockylab.com breeders, greenhouses and field crop producers. range of prescription and over-the-counter Provides contract chromatographic and mass products for cardiology, dermatology, spectrometric analysis of pharmaceuticals C SuviCa, Inc. women’s health and other areas. (both traditional drugs and biotechnology Boulder products, such as proteins and peptides and www.suvica.com C Venaxis Inc. oligonucleotides), veterinary and human Discovery and development of small Castle Rock endocrinology and forensic toxicology. molecules for the treatment of cancer. www.venaxis.com Primarily focused on advancing towards commer- Rocky Mountain Reagents, Inc. Taiga Biotechnologies, Inc. cialization, our recently patented blood-based Golden Aurora human diagnostic test, AppyScore™, to aid in the www.rmreagents.com www.taigabiotech.com diagnosis of human appendicitis and several novel Manufactures stains, culture media and chemistry Develops cellular, biologic and small mol- reproduction drugs for use in high-value animals. solutions for the medical industry, as well as ecule approaches to treat hematological titration reagents, indicators, acids, bases and diseases, including cancers, immunodefi- C Ventria Bioscience a variety of chemicals for industrial uses. ciencies and autoimmune conditions. Fort Collins www.ventria.com Saigene Biotech Inc. C Takeda America Holdings, Inc Develops a protein expression technology Denver Fort Collins platform called ExpressTec with a product www.saigene.com www.takeda.us pipeline in human nutrition and therapeutics. Developing testing processes to identify harmful Focused on developing life-saving vaccines algae blooms. to protect against emerging infectious dis- Verdant BioSciences Corporation eases worldwide. Inviragen’s lead product is Denver Sandoz a vaccine to protect against dengue fever. www.verdantbio.com Broomfield Develops plant biochemical regulators that www.us.sandoz.com C Thermo Fisher Scientific provide superior plant performance and unlock Focuses on pharmaceuticals, consumer Lafayette the productive power of plants in markets health, generics, eye care and animal health. www.thermofisher.com from floriculture to industrial agriculture. Therapeutic categories include anti-infectives, Scientific leadership and innovation in RNAi, anti-arthritics, cardiovasculars, gastrointes- Gene Expression, qPCR/PCR Detection, Verkko Biomedical, LLC tinal agents and psychotherapeutics. and Molecular Biology technologies come Aurora together with the Thermo Scientific Dharma- Verkko Biomedical was formed to commer- C Silvergate Pharmaceuticals Inc. con, Open Biosystems, ABgene, Finnzymes cialize the combustion synthesis technology Greenwood Village and Fermentas product lines to provide and manufacture medical grade customized www.silvergatepharma.com world-leading solutions for gene analysis. alpha-, beta-phase tricalcium phosphates Developer and manufacturer of pharmaceutical (Į-TCP, ȕ-TCP) as precursor components for products focused on the pediatric market. C TOLMAR, Inc. customers who operate in the biomedical/ Fort Collins medical industry. Verkko will be operating in the SixOne Solutions LLC www.tolmar.com ceramic segment of the biomaterials market. Aurora Develops and manufacturers both propri- www.sixonesolutions.com etary and generic pharmaceutical products C VetDC Developing novel products for the treat- with specific focus in therapeutic areas of Fort Collins ment and diagnosis of breast cancer. dental, dermatology and oncology. www.vet-dc.com Cancer-focused veterinary biopharma- STA Laboratories, Inc. C TopGear Automation ceutical company developing innovative Longmont Hartsel under-utilized human technologies www.stalabs.com www.topgearautomation.com for use in companion animals. Agricultural product testing laboratory that Development and validation of biomarkers offers seed quality, genomics, plant health for environmental exposure, oncology and and diagnostic services and products. related diseases.

2015-2016 BIOSCIENCE COLORADO 55 C ViroCyt, LLC yuScience LLC GeoSynFuels, LLC Denver Aurora Golden www.virocyt.com Focusing on the development of early-disease www.geosynfuels.com Focused on the commercialization of novel biomarkers in patients with multiple sclerosis (MS). Develops a low-cost method to convert technologies that enable rapid quantification cellulosic biomass into fuel. The technol- of viruses, such as the Virus Counter 2100. Z Biotech, LLC ogy uses biological mechanisms set in a Aurora solid-state fermenter (“SSF”) to convert the C VitroBiopharma www.zbiotech.com biomass into ethanol and/or methane. Golden Cost-effective biochemical analysis solutions, our www.vitrobiopharma.com focus is to develop innovative microarray and Gevo, Inc. Develops and commercializes adult stem carbohydrate products and related services. Englewood cell technology for applications in stem cell www.gevo.com research, drug discovery and development, ZeoponiX, Inc. Develops advanced biofuels like isobutanol, and therapeutic products for treatment of Boulder butanol that will provide a sustainable disease, injury and tissue regeneration. www.zeoponix.com path to the replacement of petrochemicals Investigating the immune-pathogenesis of MS, and like gasoline, diesel and jet fuel. Vitrolife, Inc. identifying key players in disease progression. Englewood Novo Energy LLC www.vitrolife.com Fort Collins Develops, manufactures and sells products www.novoenergyllc.com and systems for the preparation, cultivation Colorado-based renewable energy company that and storage of human cells, tissue and BIOFUELS AND RELATED provides state-of-the-art technology, equipment, organs. Product areas include fertility, COMPANIES and project support services for the renewable transplantation and stem cell cultivation. energy and solid waste disposal industries. BioVantage Resources, Inc. C Vivaldi Biosciences Golden PureVision Technology, Inc. Fort Collins www.bvialgae.us Fort Lupton www.vivaldibiosciences.com Delivers algae-based bioremediation www.purevisiontechnology.com Developing advanced vaccines for solutions for municipal, industrial and Develops a carbon-neutral biomass fraction- prevention of common seasonal influ- agricultural wastewater treatment. ation technology that converts cellulosic enza and emergent pandemic flu. biomass into sugars, energy and fiber that Carbo Analytics, LLC are bio-based raw materials to make many VRL Laboratories Fort Collins industrial and consumer products. Centennial www.carboanalytics.com www.vrl.net Commercial development of an online Solix BioSystems, Inc. Laboratory offers full-service regulated donor eligibil- sugar monitor with immediate application for Fort Collins ity testing for the human cell and tissue community. more cost-effective biofuels production. www.solixbiosystems.com Developed and successfully deployed a Warren Analytical Laboratory Colorado Center for Biorefining robust algal growth system (AGS®) that is Greeley and Biofuels (C2B2) based on its proprietary extended-surface www.warrenlab.com Boulder area closed photobioreactor panels. Specializes in food microbiology, mo- www.c2b2web.org lecular biology, food chemistry, residue A cooperative research and educational center Sterling Ethanol, LLC chemistry and nutritional labeling. devoted to the conversion of biomass to fuels and Sterling other products. Works to establish ground-break- www.sterlingethanol.com Wildlife Pharmaceuticals, Inc. ing research and educational programs for the Produces 42 million gallons of ethanol Fort Collins advancement of renewable energy technologies. annually, using the distiller’s grain produced www.wildpharm.com as a co-product of ethanol to the area’s Providing pharmaceuticals for the safe C Ciris Energy, Inc. cattle feeders for its high protein levels. and humane care of non-domestic Centennial and exotic wildlife species. www.cirisenergy.com Sundrop Fuels, Inc. Start-up company developing a unique Louisville Xalud Therapeutics biotechnology for the conversion of fossil www.sundropfuels.com Boulder sources of carbon, such as low-rank coals A solar gasification-based renewable www.xaludthera.com to natural gas and valuable chemicals. energy company. Novel therapies for the treatment of neuro-inflammatory diseases and inflammatory joint disorders Front Range Energy, LLC ZeaChem Windsor Lakewood YewSavin, Inc. www.frontrangeenergy.com www.zeachem.com Fort Collins Ethanol producer since 2006. Will process Developed a cellulose-based biorefinery platform www.ajorganica.com approximately 40 million gallons of ethanol and capable of producing third-generation ethanol Develops chemical and biochemical technologies. 396,000 tons of wet distillers’ grain annually. fuel and intermediate chemicals. Our indirect Successfully finished multi-step syntheses using approach leapfrogs the yield and carbon dioxide Bromination, Grignard reaction, Suzuki coupling, (CO2) problems associated with traditional Amidation, and Esterification reactions. and cellulosic-based ethanol processes.

56 BIOSCIENCE COLORADO 2015-2016 C = CBSA MEMBER

RESEARCH AND 2. Center for Health Care Innovation (CHCI): CHCI and assist in formulating development strategies pioneers new ways to deliver health care. This combined with an advanced leadership team to EDUCATION INSTITUTIONS center is focused on creating and testing new ensure speed to market, putting new products models that will enhance care and better manage and services to work where they are needed. populations. 3. Center for Translational Research C Advanced Diagnostic Laboratories (CTR): The emerging and revolutionary field of (Adx) at National Jewish Health C Colorado School of Mines biomedicine and genomics is the focus of CTR. Denver Golden www.njlabs.org www.mines.edu Centers for Disease Control and Prevention/ The Advanced Diagnostic Laboratories provide A public research university internationally Division of Vector-Borne Infectious Disease innovative services within the extraordinary recognized for its leadership in engineering, Fort Collins clinical and research environment of National applied science and related disciplines, with a www.cdc.gov/ncezid/dvbd Jewish Health. Leveraging our expertise in both special emphasis on the Earth and its resources. The Division of Vector-Borne Infectious Diseases laboratory medicine and personalized medicine, These programs, with strong interdisciplinary (DVBID) is part of the U.S. Centers for Disease we offer an ever-expanding menu of diagnostic linkages across the campus, have led to the Control and Prevention (CDC). CDC is the lead tests as well as contract research services. Our integration of bioscience and biotechnology federal agency for protecting the health and laboratories are CAP- and CLIA-certified, and have into educational and scholarly activities. safety of people at home and abroad. DVBID earned the prestigious CAP 15189℠ accreditation. CSM has created a Bioengineering and Life serves as a national and international reference Science Program that draws upon faculty and center for vector-borne viral and bacterial C BioFrontiers Institute students from all of the academic units. diseases, such as West Nile virus, Lyme disease, Boulder plague, tularemia, yellow fever and dengue. www.biofrontiers.colorado.edu C Colorado State University It coordinates national disease monitoring State-of-the art research and education facility Fort Collins, Pueblo, Denver activities, conducts field and laboratory research, that links the basic sciences, engineering, www.colostate.edu responds to epidemic situations, develops clinical practice, and industry at the As one of the nation’s leading research universities, strategies for disease prevention and control, University of Colorado’s Boulder campus. Colorado State University is committed to realizing provides diagnostic reference and epidemiologic its vision as a 21st century land-grant university. CSU consultation, and conducts technical assistance Biological Sciences Curriculum Study (BSCS) leads the world in such areas as infectious disease and professional training activities. Colorado Springs research, atmospheric science and environmental www.bscs.org science. Its faculty members are tackling such Children’s Hospital Colorado A nonprofit corporation that endeavors to improve issues as the reemergence of tuberculosis, the Aurora all students’ understanding of science and brown cloud of air pollution in Asian cities, severe www.childrenscolorado.org technology by developing exemplary curricular weather forecasting, nutrition and wellness, and Children’s Hospital Colorado has been ranked materials, supporting their widespread and effective bioterrorism. In addition to its excellent programs for more than a decade as one of the best use, providing professional development, and in those areas, CSU offers among the very best children’s hospitals nationally in U.S. News & conducting research and evaluation studies. professional programs in the United States in World Report, and as the consistent choice eight areas like veterinary medicine, occupational years in a row by area physicians for the care of Bonfils Blood Center therapy, journalism, agriculture and construction their loved ones. Founded in 1908, Children’s Denver management. Its programs in the arts, humanities Colorado is a private, not-for-profit pediatric www.bonfils.org and social sciences are also outstanding. health-care network dedicated 100 percent to One of the nation’s leading community blood caring for kids. With 1,130 pediatric specialists and centers through its commitment to quality service, Craig Hospital more than 2,300 full-time employees, Children’s innovation, research and technology. It offers a full Englewood Colorado is home to a number of nationally and range of blood products and services to healthcare www.CraigHospital.org internationally recognized medical programs. partners, including supplying rare blood units or Craig Hospital is a world-renowned, premier center helping to determine the best cross-matched unit for specialty rehabilitation and research for people C Colorado Center for Drug Discovery (C2D2) to endure the best possible patient outcomes. with spinal cord and traumatic brain injury. Fort Collins www.c2d2.org C Catholic Health Initiatives Institute C CSU Research Innovation Center A non-profit organization funded through the for Research and Innovation Fort Collins State of Colorado. The organization promotes Englewood www.csuric.org drug discovery research with Colorado www.chiresearch.org The Research Innovation Center (RIC) serves as a through a combination of funding, medicinal Founded by Catholic Health Initiatives (CHI) in vehicle to perform collaborative translational-stage chemistry and modeling expertise. 2007, the CHI Institute for Research and Innovation research with CSU’s life sciences community of partners with CHI hospitals and physicians to researchers, giving it the promise to become C Colorado Institute for Drug, Device and further the advancement of healthcare. From the birthplace of medical breakthroughs. Diagnostic Development (CID4) pioneering new models of care delivery to creating Aurora partnerships within and outside of CHI, CIRI provides Denver Botanic Gardens www.cid4.com a research community fostering innovation in three Denver CID4’s mission is to efficiently transform distinct areas: 1. Center for Clinical Research (CCR): www.botanicgardens.org Sustaining clinical research and trials is costly emerging life science technologies into One of the top-ranked botanical gardens and challenging. By creating a national model commercial successes. We do this by employing in the US, Denver Botanic Gardens offers that uses standardized procedures, policies and an experienced Technical and Business Advisory spectacular plant displays and unlimited IT infrastructures, CCR efficiently and effectively Committee to identify potential opportunities opportunities for lifelong learning. manages clinical trials across CHI’s hospital network.

2015-2016 BIOSCIENCE COLORADO 57 Denver Museum of Nature and Science National Institute of Standards Regis University Denver and Technology (NIST) Denver www.dmns.org Boulder www.regis.edu The Denver Museum of Nature and Science is www.nist.gov The School of Pharmacy aspires to be the foremost the Rocky Mountain region’s leading resource NIST is a non-regulatory federal agency that school of pharmacy in the United States where for informal science education. A variety of operates eight different science and advanced students are nurtured and developed to become exhibitions, programs, and activities help technology research divisions in Colorado. NIST’s leaders in pharmacy practice, research, education, Museum visitors experience the natural wonders list of research accomplishments includes a and public service. As a result, students graduate of Colorado, Earth and the universe. NIST senior scientist winning the Nobel Prize in as professionals who are knowledgeable, skillful, 2001 for creating the world’s first “Bose-Einstein and principled, and who are able to make a Denver School of Science and Technology condensate.” In 2003 another NIST scientist won positive impact on the dramatically changing Denver a MacArthur Fellowship for discovering a new role of pharmacists in our transforming society. www.dsstpublicschools.org quantum gas and was named by Science as one They are educated to be committed to excellence DSST Public Schools transforms urban public of the top ten scientific advances of the year. in healthcare, evidenced not only by their education by eliminating educational inequity and knowledge and abilities, but also by their quality preparing all students for success in college and C National Jewish Health of care, integrity, compassion, respect, advocacy, the 21st Century. By creating a powerful learning Denver initiative, service and leadership. To achieve community centered on core values and a shared www.njhealth.org these goals, faculty members are dedicated to commitment to academic excellence, DSST will National Jewish Health, the nation’s No. 1 providing innovative practice models, exploring double the number of college-ready graduates in the respiratory hospital in the US, attracts thousands of novel applications of basic and clinical research, Denver Public School system by 2020. Over the past adult and pediatric patients each year who come and illustrating the value of lifelong learning. decade, DSST has become one of the leading open- to us to team up with our expert physicians and enrollment STEM schools (Science, Technology, researchers and seek treatment for respiratory, Rocky Vista University College of Engineering and Mathematics) in the U.S. and has cardiac, immune and related conditions. National Osteopathic Medicine (RVUCOM ) become a destination for educators nationwide. Jewish Health is also one of the most influential Parker independent biomedical research centers in the www.rvu.edu Denver Research Institute world. More than 100 faculty members conduct Rocky Vista University College of Osteopathic Denver basic, translational, and clinical research in Medicine (RVUCOM ) is one of the newest of the www.denver-research.org immunology, respiratory medicine, allergy, cancer, 28 colleges of osteopathic medicine currently Denver Research Institute (DRI), founded in and cell and molecular biology. National Jewish established or in development in the United 1997, serves as the non-profit organization Health ranks among the top ten percent of all States. With five departments – biomedical affiliated with the VA Eastern Colorado Health institutions for NIH support and for the impact sciences, structural medicine, primary care, Care System. It is dedicated to research and its of its research papers in the fields of Molecular Osteopathic Principles and Practices, Specialty associated educational and scientific endeavors. Biology, Genetics, and Biology and Biochemistry. Medicine and Medical Informatics, the faculty and staff of RVUCOM are committed Front Range Community College National Renewable Energy Laboratory to osteopathic philosophy and heritage, Brighton, Fort Collins, Longmont and Westminster Golden and to advancing the science and the art of www.frontrange.edu www.nrel.gov the practice of osteopathic medicine. Front Range Community College, Colorado’s largest The nation’s primary laboratory for renewable community college, provides instruction, in both energy and energy efficiency research and Scientific Education & Research Institute (SERI) general education and occupational areas, which development (R&D). NREL’s mission and strategy Thornton may lead to a certificate, an associate degree, are focused on advancing the U.S. Department www.theseri.com or transfer to a four-year institution. The college of Energy’s and our nation’s energy goals. SERI is a unique institute that combines also provides college preparatory education, NREL’s R&D areas of expertise are: renewable an orthopedic clinic, specializing in spine non-credit instruction for personal and professional electricity (solar, wind, biomass, geothermal); surgery, with a clinical research unit, and development, and workplace skill development. renewable fuels (biomass, hydrogen); integrated an education and training program. With campuses located in Fort Collins, Longmont energy system engineering and testing and Westminster, the college is proud of its many (buildings, electric systems and transportation Swedish Medical Center partnerships to provide quality programs that are infrastructures); and strategic development Englewood responsive to the needs of its local communities. and analysis (economic, financial, and market www.swedishhospital.com/ analysis, planning and portfolio prioritization). Level I Trauma Center, serves as the region’s C Keystone Symposia on Molecular referral center for neurotrauma and is a and Cellular Biology Power Mountain Engineering Inc. recognized leader in the treatment of stroke. An Silverthorne Fort Collins acute care hospital with 368 licensed beds. www.keystonesymposia.org www.powermountainengineering.org A non-profit organization that serves as a catalyst Nonprofit afterschool program for gifted and United States Geological Survey (USGS) for the advancement of biomedical and life talented students in grades 8-12 who are interested - Center for Biological Informatics sciences by connecting scientists within and across in a STEM career. Students meet with community Denver disciplines at conferences and workshops held at volunteers for an entire semester to design and www.biology.usgs.gov/cbi/ venues that create an environment conducive to build an advanced project from raw materials. The Center for Biological Informatics, at the information exchange, generation of new ideas, and The program encourages our best students to Denver Federal Center, operates the national acceleration of applications that benefit society. take up college studies in STEM by immersing Biological Information Infrastructure (NBII). This them in an authentic, hands-on R&D experience. is the first comprehensive electronic gateway dedicated exclusively to biological science data and information from sources throughout the world.

58 BIOSCIENCE COLORADO 2015-2016 C = CBSA MEMBER

C University of Colorado C University of Denver FOUNDATIONS Boulder, Denver, Aurora, Colorado Springs Denver www.cu.edu www.du.edu C Boettcher Foundation Webb-Waring The University of Colorado System’s 52,000 students Strives to provide the most modern educational Biomedical Research Program and 28,000 faculty and staff contribute to every facet and research facilities in the life sciences. Its Denver of life in Colorado. The state’s economic vitality, history spans the Denver Research Institute’s www.boettcherfoundation.org educated workforce, entrepreneurial climate, development of the first NASA life monitoring Founded by the Boettcher Family in 1937 to cultural capital, health care delivery, and scientific sensors, the establishment of a state-of-the-art effectively assist, encourage and promote quality explorations all rely on the driving force of a vigorous forensics laboratory, and the 2003 acquisition of of life for the citizens of Colorado, the Boettcher state university. By working with other CU academic the Eleanor Roosevelt Institute with pioneering Foundation invests in education, community and research units, as well as local, state, and efforts in genomics and bioinformatics. In 2004 services, health, and arts & culture through merit federal funding agencies, commercial business, and the School of Engineering and Computer Science awards, scholarships and capital grants. In 2008, nonprofit organizations, CU is creating a collaborative unveiled Colorado’s first undergraduate program the Webb-Waring Institute became a part of the synergy in important areas that will better the in Bioinformatics and a master’s degree in University of Colorado and is now known as the wellness of society. The CU Institute of Bioenergetics, Bioengineering. The interdisciplinary mission of Webb-Waring Center. The Boettcher Foundation the Colorado Initiative in Molecular Biotechnology, the University enabled the Department of Biology was entrusted with the stewardship of the the Center for Computational Biology, and the Center to launch new emphases in Bioengineering, Webb-Waring Foundation’s assets. Through an for Pharmaceutical Biotechnology attract intellectual Biophysics and Cognitive Neuroscience designed innovative agreement between the Boettcher strength to Colorado, provide new educational for molecular biology majors. In addition to strong Foundation, the Webb-Waring Foundation and opportunities, and inspire innovative health and quality curricula, bioengineering and life the University of Colorado, a new funding area care advances. Research and teaching hospitals sciences at DU carry multimillion-dollar-a-year was established at the Boettcher Foundation that affiliated with the University of Colorado include: research studies in the creation of new knowledge supports the work of early-career investigators The University of Colorado Health, The Children’s and leading-edge biotechnologies to improve in the biomedical sciences in Colorado. Hospital, National Jewish Medical and Research quality of life for a worldwide community. Center, Denver Health and the VA Medical Center. C CSU Ventures, Inc. C University of Northern Colorado Fort Collins C University of Colorado Cancer Center Greeley www.csuventures.org Aurora www.unco.edu CSU Ventures, Inc. (CSUV) is a 501(c)(3) non-profit www.uch.edu/colorado-cancer-center University of Northern Colorado (UNC) is a corporation that actively supports and promotes The University of Colorado Cancer Center is multipurpose institution with a wide range the transfer of Colorado State University (CSU) Colorado’s only National Cancer Institute-designated of graduate and undergraduate programs. research and innovations into the marketplace consortium comprehensive cancer center. The The university’s mission is to prepare for the benefit of society. CSU Ventures serves center is a consortium of three state universities, individuals for advanced study, professional CSU faculty and researchers who wish to including the University of Colorado-Boulder, careers and positions of leadership. protect and license intellectual property; builds University of Colorado Denver and Colorado relationships with industries and investors State University, and six institutions (University C Work, Education and Lifelong Learning seeking to engage with CSU; and leverages of Colorado Health, a network comprised of Simulation (WELLS) Center CSU innovation to foster business formation University of Colorado Hospital, Poudre Valley Aurora and enhance regional economic vitality. Hospital, Medical Center of the Rockies and www.wellssimulationcenter.org Memorial Hospital; Children’s Hospital Colorado; For the first time in Colorado, one facility offers C University of Colorado Office of Advancement Denver Health, Denver VA Medical Center, Kaiser a complete array of state-of-the-art patient Aurora, Boulder, Colorado Springs Permanente Colorado and National Jewish Health). simulation tools for building clinical knowledge. www.cu.edu/advancement Even more exciting, high-speed datacasting The University of Colorado Office of C University of Colorado Health technology makes this unique resource available Advancement collaborates with faculty, staff, Loveland, Fort Collins, Colorado Springs remotely. Students, faculty and practicing nurses benefactors, alumni and friends to raise www.pvhs.org and physicians from throughout Colorado can private support for the university by matching Poudre Valley Health System (PVHS) and the enhance their diagnostic and clinical skills at the the passions of benefactors with the needs, University of Colorado Hospital (UCH) finalized a WELLS Center either on site or online. Housed in priorities and goals of each campus. joint operating agreement in early 2012 that creates the new Bioscience East building at Fitzsimons, the a health system its leaders say will widen health care WELLS Center represents a unique collaboration services and provide unparalleled patient care in the among educators, providers and policymakers. Rocky Mountain region. Called University of Colorado Health, the new system combines one of the top- performing community health systems in the nation with the highest-ranked academic medical center in quality in the country. With annual net revenue of $1.5 billion, it will be one of the region’s largest locally-owned health systems and, with nearly 10,000 employees, one of Colorado’s largest employers.

2015-2016 BIOSCIENCE COLORADO 59 SERVICE PROVIDERS Consulting - Regulatory, Premier Laboratory, LLC Commercialization and www.premierlab.com Clean Room Services Development Pre-Clinical Research Services, Inc. www.preclinicalresearch.com CO2Nexus, Inc. CBR International Corporation www.co2nexus.com www.cbrintl.com

Western States Sales Inc Clinipace Worldwide www.CleanRoomWorld.com www.clinipace.com GLP/non-GLP Services Medical imaging Fluoroscopy Dohmen Life Science Services Experimental Surgery Angiography www.dohmen.com Medical devices Ultrasound/Echo Construction and Facilities Proof of Concept Emerson Consultants, Inc. Device V&V Labs Toxicology Cardiovascular Devices Pilot/Acute/MTD CH2M Hill www.emersonconsultants.com GI/Ortho/Thoracic 14 and 28 Day KƐƚĞŽĂƌƚŚƌŝƟƐ www.ch2m.com WŚĂƌŵĂĐŽŬŝŶĞƟĐƐ Hellman & Associates (PK/PD/TK) CRB Engineers and Builders www.ehscompliance.com www.PreClinicalResearch.com www.crbusa.com The Mead Consulting Group, Inc. Facility Planning Arts www.meadconsultinggroup.com Pyxant Labs, Inc. www.planningartsinc.com www.pyxant.com NAMSA Howell Construction www.namsa.com www.howellconst.com Shopp Nonclinical Consulting LLC www.shoppnonclin.com Contract Manufacturing/ Design Organizations

CEA Medical Manufacturing Contract Research Organizations www.ceamedicalmanufacturing.com Design Solutions Inc. CARE Research LLC/ Colorado Histo-Prep www.design-solutions.com www.histoprep.com E2i CPC Clinical Research www.e2i.net www.cpcmed.org Evergreen Research, Inc. HemoGenix www.evergreenresearch.com www.hemogenix.com KBI Biopharma, Inc. High Quality Research, LLC (HQR) www.kbibiopharma.com Consulting - General Business www.hqrllc.com Mountainside Medical LABS, Inc. Collective IP www.mountainsidemed.com www.collectiveip.com www.labs-inc.org Vention Medical Microbial Research, Inc. Neil Burris & Associates www.ventionmedical.com [email protected] www.microbialresearch.com

MPI Research www.mpiresearch.com Distribution, Packaging and MyCROSite LLC Sales Force www.mcsps.com XPO Global Logistics NextGen Pharma Technologies, Inc. www.xpologistics.com www.nextgenpharma.com Pozzetta Scientific Plato BioPharma, Inc. www.pozzettascientific.com www.platobiopharma.com

60 BIOSCIENCE COLORADO 2015-2016 C = CBSA MEMBER

Electronic Submissions Finance, Investment, and Export Customized Insurance Products and International Services and Risk Management Solutions TruSubmit Products Liability | Global Clinical Trials www.trusubmit.com Capital Rx Consulting www.capitalrxconsulting.com Medical Devices

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62 BIOSCIENCE COLORADO 2015-2016 Electronic Publishing, Implementation and Lifecycle Management www.TruSubmit.com

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