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CAS No. Product Regulatory document

Active Pharmaceutical Ingredients

532-11-6 ANETHOLE TRITHIONE EU GMP, ASMF in progress

4858-60-0 METHYL SULFATE ASMF

62952-06-1 DL – LYSINE ACETYLSALICYLATE Technical Package

7712-50-7 NOPOXAMINE (Myrtecaine) ASMF

76157-55-6 NOPOXAMINE LAURYL SULFATE EU GMP, Technical Package

53251-94-8 ASMF

108-46-3 RESORCINOL ASMF in progress

91-16-7 VERATROLE ASMF

Custom Development & Manufacturing

M2i Life Sciences | 122 Bureaux de la Colline F-92213 Saint-Cloud Cedex Plant : Route d’Arles F-13129 Salin-de-Giraud - France Tel +33 184 760 050 | Fax +33 184 760 051 [email protected] | www.m2i-lifesciences.com CAS No. Intermediates & Building blocks End API

BETAXOLOL (management of hypertension, 63659-17-6 BETAXOLOL ETHYL-GLYCOL management of glaucoma)

BUPRENORPHINE (to treat opioid use disorder, acute pain and chronic pain) NALTREXONE ( or opioid dependence BROMOMETHYL CYCLOPROPANE management) 7051-34-5 (BMCP / CPMB) ROFLUMILAST (treatment of inflammatory conditions of the lungs such as COPD) BETAXOLOL (management of hypertension, management of glaucoma)

CYCLOBUTANE BUTORPHANOL 2987-17-9 CARBOXALDEHYDE NALBUPHINE

CYCLOBUTYL BUTORPHANOL 5006-22-4 CARBONYLCHLORIDE NALBUPHINE

LAVANDULOL (2-isopropenyl-5- 58461-27-1 Used as an aroma in perfumery and cosmetics methyl-4-hexen-1-ol)

31849-78-2 Z-1-BROMO-1-BUTENE Different flavor and fragrance agents

13154-12-6 Z -1-BROMO-1-HEXENE Different flavor and fragrance agents

TIPEPIDINE (non-opioid antitussive and expectorant) ACLIDINIUM TIOTROPIUM (anticholerginique to treat COPD and 1003-09-4 2-BROMOTHIOPHENE asthma) TIQUIZIUM BROMIDE (Spasmolytic agent) (antimuscarinic) ()

Alkylates mercaptans and other sulfur containing 590-92-1 3-BROMOPROPIONIC ACID compounds

MEBEVERINE (Antispasmodic musculotropic acting 69788-75-6 4-CHLOROBUTYL VERATRATE in the digestive and biliary tract)

Custom Development & Manufacturing

M2i Life Sciences | 122 Bureaux de la Colline F-92213 Saint-Cloud Cedex Plant : Route d’Arles F-13129 Salin-de-Giraud - France Tel +33 184 760 050 | Fax +33 184 760 051 [email protected] | www.m2i-lifesciences.com