1493 JP XV Infrared Reference Spectra

Total Page:16

File Type:pdf, Size:1020Kb

1493 JP XV Infrared Reference Spectra JP XV Infrared Reference Spectra 1493 Roxatidine Acetate Hydrochloride Preparation of sample: Potassium chloride disk method Roxithromycin Preparation of sample: Potassium bromide disk method Saccharin Preparation of sample: Potassium bromide disk method 1494 Infrared Reference Spectra JP XV Saccharin Sodium Hydrate Preparation of sample: Potassium bromide disk method Salbutamol Sulfate Preparation of sample: Potassium bromide disk method Santonin Preparation of sample: Potassium bromide disk method JP XV Infrared Reference Spectra 1495 Scopolamine Butylbromide Preparation of sample: Potassium bromide disk method Siccanin Preparation of sample: Potassium bromide disk method Sodium Fusidate Preparation of sample: Potassium bromide disk method 1496 Infrared Reference Spectra JP XV Sodium Picosulfate Hydrate Preparation of sample: Potassium bromide disk method Sodium Polystyrene Sulfonate Preparation of sample: Potassium bromide disk method Sodium Prasterone Sulfate Hydrate Preparation of sample: Potassium bromide disk method JP XV Infrared Reference Spectra 1497 Sodium Salicylate Preparation of sample: Potassium bromide disk method Sodium Valproate Preparation of sample: Liquid film method Spiramycin Acetate Preparation of sample: Potassium bromide disk method 1498 Infrared Reference Spectra JP XV Spironolactone Preparation of sample: Potassium bromide disk method Sulbactam Sodium Preparation of sample: Potassium bromide disk method Sulbenicillin Sodium Preparation of sample: Potassium bromide disk method JP XV Infrared Reference Spectra 1499 Sulfadiazine Silver Preparation of sample: Paste method Sulfamethizole Preparation of sample: Potassium bromide disk method Sulfamethoxazole Preparation of sample: Potassium bromide disk method 1500 Infrared Reference Spectra JP XV Sulfamonomethoxine Hydrate Preparation of sample: Potassium bromide disk method Sulfinpyrazone Preparation of sample: Potassium bromide disk method Sulpiride Preparation of sample: Potassium bromide disk method JP XV Infrared Reference Spectra 1501 Sultamicillin Tosilate Hydrate Preparation of sample: Paste method Suxamethonium Chloride Hydrate Preparation of sample: Potassium bromide disk method Talampicillin Hydrochloride Preparation of sample: Potassium bromide disk method 1502 Infrared Reference Spectra JP XV Tamsulosin Hydrochloride Preparation of sample: Potassium chloride disk method Taurine Preparation of sample: Potassium bromide disk method Tegafur Preparation of sample: Potassium bromide disk method JP XV Infrared Reference Spectra 1503 Testosterone Propionate Preparation of sample: Potassium bromide disk method Tetracycline Hydrochloride Preparation of sample: Potassium chloride disk method Theophylline Preparation of sample: Potassium bromide disk method 1504 Infrared Reference Spectra JP XV Thiamine Chloride Hydrochloride Preparation of sample: Potassium bromide disk method Thiamylal Sodium Preparation of sample: Potassium bromide disk method Thioridazine Hydrochloride Preparation of sample: Potassium chloride disk method JP XV Infrared Reference Spectra 1505 L-Threonine Preparation of sample: Potassium bromide disk method Tiaramide Hydrochloride Preparation of sample: Potassium chloride disk method Ticlopidine Hydrochloride Preparation of sample: Potassium bromide disk method 1506 Infrared Reference Spectra JP XV Timepidium Bromide Hydrate Preparation of sample: Potassium bromide disk method Timolol Maleate Preparation of sample: Potassium bromide disk method Tinidazole Preparation of sample: Potassium bromide disk method JP XV Infrared Reference Spectra 1507 Tipepidine Hibenzate Preparation of sample: Potassium bromide disk method Tizanidine Hydrochloride Preparation of sample: Potassium chloride disk method Tocopherol Preparation of sample: Liquid film method 1508 Infrared Reference Spectra JP XV Tocopherol Acetate Preparation of sample: Liquid film method Tocopherol Calcium Succinate Preparation of sample: Liquid film method (measured as a solution of 0.08 g of Tocopherol Calcium Succinate in 0.2 mL of carbon tetrachloride) Tocopherol Nicotinate Preparation of sample: Liquid film method JP XV Infrared Reference Spectra 1509 Todralazine Hydrochloride Hydrate Preparation of sample: Potassium chloride disk method Tofisopam Preparation of sample: Potassium bromide disk method Tolazamide Preparation of sample: Potassium bromide disk method 1510 Infrared Reference Spectra JP XV Tolnaftate Preparation of sample: Potassium bromide disk method Tranexamic Acid Preparation of sample: Potassium bromide disk method Triamcinolone Preparation of sample: Potassium bromide disk method JP XV Infrared Reference Spectra 1511 Triamcinolone Acetonide Preparation of sample: Potassium bromide disk method Trichlormethiazide Preparation of sample: Potassium bromide disk method Triclofos Sodium Preparation of sample: Potassium bromide disk method 1512 Infrared Reference Spectra JP XV Trimebutine Maleate Preparation of sample: Potassium bromide disk method Trimetazidine Hydrochloride Preparation of sample: Potassium chloride disk method Trimethadione Preparation of sample: Solution method (measured as a solution in chloroform) JP XV Infrared Reference Spectra 1513 Trimetoquinol Hydrochloride Hydrate Preparation of sample: Potassium chloride disk method L-Tryptophan Preparation of sample: Potassium bromide disk method Tulobuterol Hydrochloride Preparation of sample: Potassium bromide disk method 1514 Infrared Reference Spectra JP XV Ubidecarenone Preparation of sample: Potassium bromide disk method Urapidil Preparation of sample: Potassium bromide disk method L-Valine Preparation of sample: Potassium bromide disk method JP XV Infrared Reference Spectra 1515 Vancomycin Hydrochloride Preparation of sample: Potassium bromide disk method Verapamil Hydrochloride Preparation of sample: Potassium chloride disk method Vinblastine Sulfate Preparation of sample: Potassium bromide disk method 1516 Infrared Reference Spectra JP XV Vincristine Sulfate Preparation of sample: Solution method (measured as a solution in chloroform) Voglibose Preparation of sample: Potassium bromide disk method Warfarin Potassium Preparation of sample: Potassium bromide disk method JP XV Infrared Reference Spectra 1517 Xylitol Preparation of sample: Potassium bromide disk method Zaltoprofen Preparation of sample: Potassium bromide disk method.
Recommended publications
  • Regasta-Tab-Leaflet-Pakistan
    50mg Tablets DESCRIPTION Investigations : Increased AST (SGOT), increased ALT (SGPT), increased γ-GTP, Regasta (Itopride HCl) is a prokinetic benzamide derivative. It inhibits dopamine and increased alkaline phosphatase and increased bilirubin. have a gastrokinetic effect. Chemically, Itopride HCl is N-[4-[2-(Dimethylamino) ethoxy]benzyl]-3,4- CONTRAINDICATIONS dimethoxybenzamide monohydrochloride. Its molecular formula is C20H26N2O4.HCl and Itopride HCl is contraindicated in: the structural formula is: - Patients with known hypersensitivity to itopride HCl or any of the excipient of the product. 0 - Patient s in whom an increase in gastrointestinal motility could be harmful e.g., gastrointestinal hemorrhage, mechanical obstruction or perforation. N CH3 PRECAUTIONS H3C H N HCI - Itopride HCl should be used with caution since it enhances the action of acetylcholine. 0 0 CH3 Also, caution is advised in treatment of patients suffering from Parkinson's disease and conditions involving dopamine regulation issues. 0 - Itopride HCl should not be used aimlessly for a long term when no improvement of H3C Itopride HCl gastrointestinal symptoms is observed. Pregnancy and Nursing Mothers QUALITATIVE & QUANTITATIVE COMPOSITION Itopride HCl should be used in pregnant women or in women who may possibly be Regasta (Itopride HCl) is available for oral administration as: pregnant only if the expected therapeutic benefits outweigh the possible risks associated with treatment. The safety of itopride HCl in pregnant women has not been established. Regasta Tablets 50mg It is ideal not to use itopride HCl in women during lactation, but if it is necessary, breast Each film-coated tablet contains: feeding should be avoided during the treatment of itopride HCl.
    [Show full text]
  • Integrating Complementary Medicine Into Cardiovascular Medicine
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Journal of the American College of Cardiology Vol. 46, No. 1, 2005 © 2005 by the American College of Cardiology Foundation ISSN 0735-1097/05/$30.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2005.05.031 ACCF COMPLEMENTARY MEDICINE EXPERT CONSENSUS DOCUMENT Integrating Complementary Medicine Into Cardiovascular Medicine A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine) WRITING COMMITTEE MEMBERS JOHN H. K. VOGEL, MD, MACC, Chair STEVEN F. BOLLING, MD, FACC BRIAN OLSHANSKY, MD, FACC REBECCA B. COSTELLO, PHD KENNETH R. PELLETIER, MD(HC), PHD ERMINIA M. GUARNERI, MD, FACC CYNTHIA M. TRACY, MD, FACC MITCHELL W. KRUCOFF, MD, FACC, FCCP ROBERT A. VOGEL, MD, FACC JOHN C. LONGHURST, MD, PHD, FACC TASK FORCE MEMBERS ROBERT A. VOGEL, MD, FACC, Chair JONATHAN ABRAMS, MD, FACC SANJIV KAUL, MBBS, FACC JEFFREY L. ANDERSON, MD, FACC ROBERT C. LICHTENBERG, MD, FACC ERIC R. BATES, MD, FACC JONATHAN R. LINDNER, MD, FACC BRUCE R. BRODIE, MD, FACC* ROBERT A. O’ROURKE, MD, FACC† CINDY L. GRINES, MD, FACC GERALD M. POHOST, MD, FACC PETER G. DANIAS, MD, PHD, FACC* RICHARD S. SCHOFIELD, MD, FACC GABRIEL GREGORATOS, MD, FACC* SAMUEL J. SHUBROOKS, MD, FACC MARK A. HLATKY, MD, FACC CYNTHIA M. TRACY, MD, FACC* JUDITH S. HOCHMAN, MD, FACC* WILLIAM L. WINTERS, JR, MD, MACC* *Former members of Task Force; †Former chair of Task Force The recommendations set forth in this report are those of the Writing Committee and do not necessarily reflect the official position of the American College of Cardiology Foundation.
    [Show full text]
  • Isopropamide Iodide
    www.chemicalland21.com ISOPROPAMIDE IODIDE SYNONYMS (3-Carbamoyl-3,3-diphenylpropyl)diisopropylmethylammonium iodide; 2,2-Diphenyl-4- diisopropylaminobutyramide methiodide; 4-(Diisopropylamino)-2,2-diphenylbutyramide methiodide; gamma-(Aminocarbonyl)-N-methyl-N,N-bis(1-methylethyl)-gamma-phenylbenzenepropanaminium iodide; Iodure d'isopropamide; Ioduro de isopropamida; Isopropamide ioduro; Isopropamidi iodidum; Isoproponum iodide; PRODUCT IDENTIFICATION CAS RN 71-81-8 EINECS RN 200-766-8 FORMULA C23H33IN2O MOL WEIGHT 480.43 PHYSICAL AND CHEMICAL PROPERTIES PHYSICAL STATE white to off-white powder MELTING POINT 199 C BOILING POINT DENSITY SOLUBILITY IN WATER pH VAPOR DENSITY REFRACTIVE INDEX FLASH POINT GENERAL DESCRIPTION Isopropamide is a long-acting anticholinergic and antimuscarinic drug of quaternary ammonium structure. It is used in the form of the iodide, (also bromide or chloride) to treat peptic ulcer and to suppress gastric secretion other gastrointestinal disorders. Brands of Isopropamide drugs: Darbid Dipramide Isamide Marygin-M Piaccamide Priamide Priazimide Sanulcin Tyrimide Quaternary ammonium anticholinergics (Synthetic) ATC Code Product CAS RN. A03AB01 Benzilonium bromide 1050-48-2 A03AB02 Glycopyrrolate 596-51-0 A03AB03 Oxyphenonium 14214-84-7 A03AB04 Penthienate 22064-27-3 A03AB05 Propantheline 50-34-0 A03AB06 Otilonium bromide 26095-59-0 A03AB07 Methantheline 5818-17-7 Please mail us if you want to sell your product or need to buy some products) www.chemicalland21.com ISOPROPAMIDE IODIDE A03AB08 Tridihexethyl 60-49-1 A03AB09 Isopropamide 7492-32-2 A03AB10 Hexocyclium 6004-98-4 A03AB11 Poldine 596-50-9 A03AB12 Mepenzolic acid 25990-43-6 A03AB13 Bevonium 33371-53-8 A03AB14 Pipenzolate 13473-38-6 A03AB15 Diphemanil methylsulfate 62-97-5 A03AB16 (2-Benzhydryloxyethyl)diethyl-methylammonium iodide A03AB17 Tiemonium iodide 144-12-7 A03AB18 Prifinium bromide 4630-95-9 A03AB19 Timepidium bromide 35035-05-3 A03AB21 Fenpiverinium bromide 125-60-0 03AB53 Oxyphenonium, combinations STABILITY AND REACTIVITY STABILITY Stable under normal conditions.
    [Show full text]
  • The National Drugs List
    ^ ^ ^ ^ ^[ ^ The National Drugs List Of Syrian Arab Republic Sexth Edition 2006 ! " # "$ % &'() " # * +$, -. / & 0 /+12 3 4" 5 "$ . "$ 67"5,) 0 " /! !2 4? @ % 88 9 3: " # "$ ;+<=2 – G# H H2 I) – 6( – 65 : A B C "5 : , D )* . J!* HK"3 H"$ T ) 4 B K<) +$ LMA N O 3 4P<B &Q / RS ) H< C4VH /430 / 1988 V W* < C A GQ ") 4V / 1000 / C4VH /820 / 2001 V XX K<# C ,V /500 / 1992 V "!X V /946 / 2004 V Z < C V /914 / 2003 V ) < ] +$, [2 / ,) @# @ S%Q2 J"= [ &<\ @ +$ LMA 1 O \ . S X '( ^ & M_ `AB @ &' 3 4" + @ V= 4 )\ " : N " # "$ 6 ) G" 3Q + a C G /<"B d3: C K7 e , fM 4 Q b"$ " < $\ c"7: 5) G . HHH3Q J # Hg ' V"h 6< G* H5 !" # $%" & $' ,* ( )* + 2 ا اوا ادو +% 5 j 2 i1 6 B J' 6<X " 6"[ i2 "$ "< * i3 10 6 i4 11 6! ^ i5 13 6<X "!# * i6 15 7 G!, 6 - k 24"$d dl ?K V *4V h 63[46 ' i8 19 Adl 20 "( 2 i9 20 G Q) 6 i10 20 a 6 m[, 6 i11 21 ?K V $n i12 21 "% * i13 23 b+ 6 i14 23 oe C * i15 24 !, 2 6\ i16 25 C V pq * i17 26 ( S 6) 1, ++ &"r i19 3 +% 27 G 6 ""% i19 28 ^ Ks 2 i20 31 % Ks 2 i21 32 s * i22 35 " " * i23 37 "$ * i24 38 6" i25 39 V t h Gu* v!* 2 i26 39 ( 2 i27 40 B w< Ks 2 i28 40 d C &"r i29 42 "' 6 i30 42 " * i31 42 ":< * i32 5 ./ 0" -33 4 : ANAESTHETICS $ 1 2 -1 :GENERAL ANAESTHETICS AND OXYGEN 4 $1 2 2- ATRACURIUM BESYLATE DROPERIDOL ETHER FENTANYL HALOTHANE ISOFLURANE KETAMINE HCL NITROUS OXIDE OXYGEN PROPOFOL REMIFENTANIL SEVOFLURANE SUFENTANIL THIOPENTAL :LOCAL ANAESTHETICS !67$1 2 -5 AMYLEINE HCL=AMYLOCAINE ARTICAINE BENZOCAINE BUPIVACAINE CINCHOCAINE LIDOCAINE MEPIVACAINE OXETHAZAINE PRAMOXINE PRILOCAINE PREOPERATIVE MEDICATION & SEDATION FOR 9*: ;< " 2 -8 : : SHORT -TERM PROCEDURES ATROPINE DIAZEPAM INJ.
    [Show full text]
  • WITHOUTUS010307409B2 (12 ) United States Patent ( 10 ) Patent No
    WITHOUTUS010307409B2 (12 ) United States Patent ( 10 ) Patent No. : US 10 , 307 ,409 B2 Chase et al. (45 ) Date of Patent: Jun . 4 , 2019 ( 54 ) MUSCARINIC COMBINATIONS AND THEIR (52 ) U . S . CI. USE FOR COMBATING CPC . .. .. A61K 31/ 4439 (2013 . 01 ) ; A61K 9 /0056 HYPOCHOLINERGIC DISORDERS OF THE (2013 . 01 ) ; A61K 9 / 7023 ( 2013 . 01 ) ; A61K CENTRAL NERVOUS SYSTEM 31 / 166 ( 2013 . 01 ) ; A61K 31 / 216 ( 2013 . 01 ) ; A61K 31 /4178 ( 2013 .01 ) ; A61K 31/ 439 (71 ) Applicant: Chase Pharmaceuticals Corporation , ( 2013 .01 ) ; A61K 31 /44 (2013 . 01 ) ; A61K Washington , DC (US ) 31/ 454 (2013 .01 ) ; A61K 31/ 4725 ( 2013 .01 ) ; A61K 31 /517 (2013 .01 ) ; A61K 45 / 06 ( 72 ) Inventors : Thomas N . Chase , Washington , DC (2013 . 01 ) (US ) ; Kathleen E . Clarence -Smith , ( 58 ) Field of Classification Search Washington , DC (US ) CPC .. A61K 31/ 167 ; A61K 31/ 216 ; A61K 31/ 439 ; A61K 31 /454 ; A61K 31 /4439 ; A61K (73 ) Assignee : Chase Pharmaceuticals Corporation , 31 /4175 ; A61K 31 /4725 Washington , DC (US ) See application file for complete search history. ( * ) Notice : Subject to any disclaimer, the term of this (56 ) References Cited patent is extended or adjusted under 35 U . S . C . 154 (b ) by 0 days . U . S . PATENT DOCUMENTS 5 ,534 ,520 A 7 / 1996 Fisher et al. ( 21) Appl . No. : 15 /260 , 996 2008 /0306103 Al 12 /2008 Fisher et al. 2011/ 0021503 A1* 1/ 2011 Chase . .. A61K 31/ 27 ( 22 ) Filed : Sep . 9 , 2016 514 / 215 2011/ 0071135 A1 * 3 / 2011 Chase . .. .. .. A61K 31/ 166 (65 ) Prior Publication Data 514 / 215 2011 /0245294 Al 10 / 2011 Paborji et al.
    [Show full text]
  • Investigation of Influence of Diazepam, Valproate, Cyproheptadine and Cortisol on the Rewarding Ventral Tegmental Self-Stimulation Behaviour
    Ind. J. Physio!. Pharmac., Volume 33, Number 3, 1989 INVESTIGATION OF INFLUENCE OF DIAZEPAM, VALPROATE, CYPROHEPTADINE AND CORTISOL ON THE REWARDING VENTRAL TEGMENTAL SELF-STIMULATION BEHAVIOUR SONTI V. RAMANA AND T. DESIRAJU· Department ofNeurophysiology, National Institute of Mental Health arzd Neuro Sciences, Bangalore - 560 029 ( Received on June IS, 1989 ) Abstract: Experiments were carried on in the Wistar rats having self-stimulation (88) electrodes implanted chronically in substantia nigra-ventral tegmental area (SN-VTA) to examine whether modulations of GABAergic, serotonergic, histaminergic, dopaminergic, and glucocorticoid neuronal receptor functions will affect or not the brain reward system and the 88 behaviour. The modulalon are the wellknown drugs: diazepam which is a facilitator ohome of the GABA recepton, and used clinically (or its tranquilising, anxiolytic, sedative-hypnotic and anti-convulsant properties: sodium valproate which is known to enhance the GABA synapse function, and used clinically for its anti­ convulsant property; haloperidol which is a dopaminergic receptor (D2) blocker, and clinically used for its anti-psychotic property; cyproheptadine which is both anti-histaminic and anti-serotonergic (blocka 5-HT2 receptor), used clinically for its antihistaminic and other beneficial properties; and hydrocortisone which is the stress-resisting glucocorticoid having direct effects on both brain and body cells, used clinically for the wide-ranging glucocorticoid therapeutic effects. The results revealed that systemic administration of these drugs, except haloperidol, caused no significant influenee on the 88 behaviour, thereby indicating that these nondopaminergic drugs have no effect on brain-reward system and also these categories of synaptic actions are not likely to be involved in the primary organization of the mechanisms of the brain-reward system.
    [Show full text]
  • Muscarinic Acetylcholine Receptor
    mAChR Muscarinic acetylcholine receptor mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia. www.MedChemExpress.com 1 mAChR Inhibitors & Modulators (+)-Cevimeline hydrochloride hemihydrate (-)-Cevimeline hydrochloride hemihydrate Cat. No.: HY-76772A Cat. No.: HY-76772B Bioactivity: Cevimeline hydrochloride hemihydrate, a novel muscarinic Bioactivity: Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. IC50 value: Target: mAChR xerostomia in Sjogren's syndrome. IC50 value: Target: mAChR The general pharmacol. properties of this drug on the The general pharmacol. properties of this drug on the gastrointestinal, urinary, and reproductive systems and other… gastrointestinal, urinary, and reproductive systems and other… Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 1 mg, 5 mg AC260584 Aclidinium Bromide Cat. No.: HY-100336 (LAS 34273; LAS-W 330) Cat.
    [Show full text]
  • Effect of Picrotoxin and Cyproheptadine Pretreatment On
    Int J Biol Med Res. 2012; 3(2): 1606-1608 Int J Biol Med Res www.biomedscidirect.com Volume 2, Issue 4, Jan 2012 Contents lists available at BioMedSciDirect Publications International Journal of Biological & Medical Research BioMedSciDirect Journal homepage: www.biomedscidirect.com International Journal of Publications BIOLOGICAL AND MEDICAL RESEARCH Original article Effect of picrotoxin and cyproheptadine pretreatment on sodium valproate induced wet dog shake behavior in rats B M Sattigeri*, J J Balsara, J H Jadhav Department of pharmacology, Sumandeep Vidyapeeth’s SBKS & MIRC, Piparia, Vadodra Gujaart Department of pharmacology, Krishna Institute of Medical Sciences, Malkapur, Karad (Dist.Satara) 415110, Maharashtra, India A R T I C L E I N F O A B S T R A C T Keywords: Sodium valproate, a broad spectrum antiepileptic elevates the brain GABA levels by various Cyproheptadine mechanisms. Histological, electrophysiological and the biochemical studies suggest a Picrotoxin Sodium valproate regulatory role of GABA on dopaminergic neurons. Behavioral studies in animals provide an Wet Dog Shake Behavior additional evidence for interaction between GABAergic and DAergic systems. Valproate at 200- 500mg/kg induces Wet Dog Shake (WDS) behavior in rats. The WDS behavior in rats and head twitch responses in mice is evoked by 5- hydroxy-tryptophan (5-HT), the 5-HT precursor, the directly acting non-selective 5-HT receptor agonists and 5-HT releasers. In order to determine the involvement of GABAergic and 5-HTergic mechanism in the induction of WDS behavior by valproate in rats, the study was taken upto investigate the effect picrotoxin and cyproheptadine pretreatment on valproate induced WDS in rats.
    [Show full text]
  • Contraception and Misconceptions
    CONTRACEPTION AND MISCONCEPTIONS CONTRACEPTION IN WOMEN WITH MENTAL ILLNESS OVERVIEW Hormones and mood How mental illness impacts on contraceptive choice Ideal contraception Pro and cons of contraceptive methods in women with mental illness Hormonal contraception and mood ESTROGENS anti-inflammatory neuroprotective effects of estradiol modulation of the limbic processing memory of emotionally-relevant information. estradiol “beneficially” modulates pathways implicated in the pathophysiology of depression, including serotonin and norepinephrine pathways PROGESTROGENS Previously thought to be anxiogenic, depressogenic Breakdown products Depression – alpha hydroxy progestrogen breakdown products pro – inflammatory, anxiogenic HORMONES AND MOODS – COMPLEX INTERPLAY MENTAL ILLNESS AND CONTRACEPTIVE CHOICE Effect of mental illness on contraceptive choice Effect of contraceptive choice on mental illness Drug interactions EFFECT MENTAL ILLNESS ON CONTRACEPTIVE CHOICE Impulsive Poor planning Cognitive and problem judgement Poor adherence IMPULSIVITY COGNITION POOR JUDGEMENT LETS NOT FORGET SUBSTANCES…… TYPES OF CONTRACEPTION No method Non hormonal Condom/Femidom Diaphragm Non hormone containing IUCD (Copper T) Hormonal COC POP Mirena Evra Patch Nuva Ring Implant ORAL CONTRACEPTIVES POP – avoid Same time every day COC Pros Effective Reduction PMS – monophasic estrogen dominant pill eg Femodene, Yaz, Nordette Cons Drug interactions Pill burden Daily dose EVRA PATCH Weekly patch Transdermal system: 150 mcg/day
    [Show full text]
  • 209627Orig1s000
    CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 209627Orig1s000 MULTI-DISCIPLINE REVIEW Summary Review Office Director Cross Discipline Team Leader Review Clinical Review Non-Clinical Review Statistical Review Clinical Pharmacology Review Reviewers of Multi-Disciplinary Review and Evaluation SECTIONS OFFICE/ AUTHORED/ ACKNOWLEDGED/ DISCIPLINE REVIEWER DIVISION APPROVED Mark Seggel, Ph.D. OPQ/ONDP/DNDP2 Authored: Section 4.2 Digitally signed by Mark R. Seggel -S CMC Lead DN: c=US, o=U.S. Government, ou=HHS, ou=FDA, ou=People, cn=Mark R. Signature: Mark R. Seggel -S Seggel -S, 0.9.2342.19200300.100.1.1=1300071539 Date: 2018.08.08 16:29:15 -04'00' Frederic Moulin, DVM, PhD OND/ODE3/DBRUP Authored: Section 5 Pharmacology/ Digitally signed by Frederic Moulin -S Toxicology DN: c=US, o=U.S. Government, ou=HHS, ou=FDA, ou=People, Reviewer Signature: Frederic Moulin -S 0.9.2342.19200300.100.1.1=2001708658, cn=Frederic Moulin -S Date: 2018.08.08 15:26:57 -04'00' Kimberly Hatfield, PhD OND/ODE3/DBRUP Approved: Section 5 Pharmacology/ Toxicology Digitally signed by Kimberly P. Hatfield -S DN: c=US, o=U.S. Government, ou=HHS, ou=FDA, ou=People, Team Leader Signature: Kimberly P. Hatfield -S 0.9.2342.19200300.100.1.1=1300387215, cn=Kimberly P. Hatfield -S Date: 2018.08.08 14:56:10 -04'00' Li Li, Ph.D. OCP/DCP3 Authored: Sections 6 and 17.3 Clinical Pharmacology Dig ta ly signed by Li Li S DN c=US o=U S Government ou=HHS ou=FDA ou=People Reviewer cn=Li Li S Signature: Li Li -S 0 9 2342 19200300 100 1 1=20005 08577 Date 2018 08 08 15 39 23 04'00' Doanh Tran, Ph.D.
    [Show full text]
  • Wo 2010/075090 A2
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 1 July 2010 (01.07.2010) WO 2010/075090 A2 (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 409/14 (2006.01) A61K 31/7028 (2006.01) kind of national protection available): AE, AG, AL, AM, C07D 409/12 (2006.01) A61P 11/06 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2009/068073 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 15 December 2009 (15.12.2009) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (25) Filing Language: English SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, (26) Publication Language: English TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 61/122,478 15 December 2008 (15.12.2008) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, (71) Applicant (for all designated States except US): AUS- ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, PEX PHARMACEUTICALS, INC.
    [Show full text]
  • Valproate-Olanzapine-Nifedipine Interaction Related Pedal Edema
    Letter-to-the Editor Taiwanese Journal of Psychiatry (Taipei) Vol. 28 No. 3 2014 • 181 • Valproate-olanzapine-nifedipine Interaction Related Pedal Edema Patient’s bilateral pedal pitting edema did not Case Report resolve spontaneously after discontinuing olan- zapine until he received diuretics with furosemide A 45-year-old single male patient with bipo- 40 mg/day and spironolactone 75 mg/day on the lar I disorder was admitted to acute ward of our 21st day of pitting edema. He required further hospital due to depressive mood with irritability treatment, and had normal fi ndings in physical ex- for more than one month. The fi nding of physical amination and repeated laboratory tests. examination at admission revealed no bilateral pedal edema under long-term usage of valproate Comment 700 mg/day as mood stabilizer, nifedipine 30 mg/ day for essential hypertension, and allopurinol There have been some clinical reports to as- 100 mg/day for gouty arthritis before hospitaliza- sociate olanzapine treatment with bilateral lower tion. The results of laboratory tests for electro- extremity edema since 2000 [1]. Pre-clinical trials lytes, renal function, liver function, chest X-ray, of oral olanzapine (doses being equal or greater and electrocardiography were also within normal than 2.5 mg/day) have also reported peripheral limits. edema as a rare adverse event. The pathophysio- During this hospitalization, we added olan- logical mechanism of low extremity edema re- zapine 5 mg/day to control manic symptoms. Five mains unknown, although some mechanisms days later, he reported bilateral swelling over low- could be proposed, such as olanzapine’s blockage er legs and ankles, a bilateral 2+ pitting edema in of α1, M1, M3 and 5-HT2 receptors [2, 3].
    [Show full text]