What if our young cancer researchers traded their microscopes for briefcases?

Annual Report | 2010

Today, most cancer researchers are not free to follow their own ideas until they are in their 40s.

We are at risk The average age today's scientists gain independent funding is 42.

42 T of losing this N 41 40 01 GRA H R I 39

38 generation’s The average age a Nobel Prize 37 winner in Medicine makes their 36 groundbreaking discovery is 37.8.*

average age of first N 35 top young talent. 34 1980 ’81 ’82 ’83 ’84 ’85 ’86 ’87 ’88 ’89 ’90 ’91 ’92 ’93 ’94 ’95 ’96 ’97 ’98 ’99 ’00 ’01 ’02 ’03 ’04 ’05 ’06 ’07 ’08 2009

year

*Data includes Nobel Prize winners in Physiology or Medicine between 1962 and 2009.

They are actively discouraged from taking risks on bold ideas.

Of the $30 billion the National Institutes of Health spends each year on biomedical research, less than 1% is spent on high-risk ideas.

1. The Damon Runyon Cancer Research Foundation 2. 2010 annual report

For more than 64 years, the Damon Runyon Cancer Research Foundation has been dedicated to keeping But we won’t the best young scientists in cancer research. Today, our role is even more important. Through let that happen. our innovative and highly prestigious award programs, we are: • Accelerating the careers of the most promising scientists • Funding their bold ideas

Because the best young researchers drive breakthroughs.

3. The Damon Runyon Cancer Research Foundation 4. 2010 annual report

Accelerating Igniting young minds to fight cancer.

Because of the Damon independence. Runyon Fellowship, The training of a biomedical researcher can take more I was allowed more free than a decade, and ends with a postdoctoral fellowship reign. It let me build working in the laboratory of a senior scientist. At a time the foundation for when their college friends are becoming managing an interesting course directors, vice presidents and partners, most postdocs of events that led are still working on someone else’s ideas. to where I am today. Not a Damon Runyon Fellow. We identify the most brilliant young scientists and provide them with Gregory J. Hannon, PhD independent funding to pursue their own ideas. PROFESSOR AND HHMI INVESTIGATOR, Cold Spring Harbor Laboratory, NY Damon Runyon Fellow ’92-’94 Pioneer in the field of RNA interference (RNAi) and a key player in the discovery of microRNAs, which are now definitively linked to the development of cancer. Esquire Genius Issue 2005, Science ‘Breakthrough of the Decade’

At age 28, Greg Hannon knew that before him RNAi is now an essential tool for cancer scientists lay a long and difficult career. A young scientist’s worldwide, and Greg is a recognized leader in work life is one of extended hours, low pay, and this important field. His work has led to multiple a protracted training period during which one’s awards and accolades, and continues to inform own ideas take second place to those of senior and shape specific therapies that target cancer scientists. cells but leave healthy cells alone.

“Science is a hard road. The work that we do is an Greg, now a Professor at Cold Spring Harbor exercise in tolerating failure with the occasional Laboratory and a Howard Hughes Medical reinforcement—if you’re lucky—of a spectacular Institute Investigator, stays closely connected to success. For the most part, people are encouraged Damon Runyon as a member of our Innovation to play it safe.” Award Committee. Recently, he returned to speak to the next generation of Damon Runyon Fellows Greg won his Damon Runyon Fellowship in 1992 at one of our annual scientific retreats. when he was in his late twenties. He was still in training, but now had his own funding, which “What the Fellowship offers young scientists is meant that he could set his own agenda and ask encouragement and an ability to renew their his own questions. focus. It gives them the confidence to do the hard experiments. “It was amazing getting the Fellowship. The great thing about it was that it gave me “It’s easy to do an experiment that will work, a lot of freedom. And the work I was doing in it’s easy to do the next logical step, it’s easy to the latter part of my Fellowship put me in the do something where you know there will be a mindset to really notice and see the potential payoff. What’s hard is taking the risk, taking of RNAi.” a path where the science is important but you’re not really sure of the outcome. And anything In 2001, Greg was among the first to describe and we can do to train people as early as possible to utilize a groundbreaking mechanism for studying reach for the big goal, I think we should do. cancer development. RNA interference (RNAi) enables scientists to turn off individual genes, “It’s programs like the Fellowship Award that and Greg began pioneering its use to identify new help give young scientists the confidence targets against cancer. to reach for the stars.”

5. The Damon Runyon Cancer Research Foundation 6. 2010 annual report

Encouraging Ideas that can change the world.

If this project hadn’t bold ideas. been funded by Funding of biomedical science is surprisingly risk- Damon Runyon, I averse. Most money goes to safe bets that lead to slow, think I’d be putting incremental progress. Damon Runyon seeks out bold my energies in other ideas. We encourage our scientists to ask “what if?” directions. And I doubt my work would have had the potential to impact so many lives.

David G. Kirsch, MD, PhD Associate Professor, Duke University, NC Damon Runyon-Rachleff Innovator ’07-’10 Radiation oncologist, physician-scientist and inventor, Dr. David G. Kirsch is building a novel device that could help thousands of patients avoid potentially harmful treatments.

At age 31, David Kirsch, a resident in radiation Seeing the potential in David and his idea, oncology, saw firsthand the suffering of Damon Runyon granted him an Innovation patients going through radiation therapy and Award in 2007. David immediately began testing chemotherapy treatments. When he realized that fluorescent imaging probes that are activated these treatments were unnecessary for many in tumors. He also started work in collaboration patients, he was motivated to help. with engineers at MIT to build an imaging device that surgeons could use to visualize the activated “I saw that we were treating a lot of patients with probes in cancer cells. radiation therapy because we were worried that they would have a few cells left behind after Damon Runyon’s belief in him was well founded. surgery. We didn’t know one way or another. A short three years later, David reports that his We were treating a large population of patients device has already been used extensively to in order to save the handful who did have detect residual cancer cells in mice. He now has microscopic residual cancer.” more than half a million dollars of new grants to help translate this research into the operating David suggested that if surgeons could see room. The collaboration he formed with his whether residual cancer cells remained behind MIT colleagues has attracted venture capital after tumors were removed, they could then investment. He hopes to be conducting Phase I decide if a patient needed additional therapy. clinical trials in humans by fall of 2011.

“When I told radiologists I had a goal to image If successful, David’s project will enable single cancer cells during surgery, they told thousands of patients to avoid the trauma of me it would never happen,” he says. radiation and chemotherapy.

David had scant preliminary research for his David says of his Innovation Award funding: idea and only a short track record of excellent “If this project hadn’t been funded by Damon work in a related field. He knew he had no hope of Runyon, I think I’d be putting my energies in receiving funding from traditional sources, which other directions. And I doubt my work would favor low-risk research by senior scientists. have had the potential to impact so many lives.”

7. The Damon Runyon Cancer Research Foundation 8. 2010 annual report

Damon Runyon Board of Directors

Steven J. Burakoff, MD Ronald Levy, MD Director, The Tisch Cancer Institute Chief, Division of Oncology Mount Sinai Medical Center Professor of Medicine New York, New York Stanford University School of Medicine Stanford, California William L. Carroll, MD Director Mr. David G. Marshall Keeping the NYU Cancer Institute Chairman and CEO New York, New York Amerimar Realty Company Philadelphia, Pennsylvania Mr. Gary E. Erlbaum best President Mr. John H. Myers Greentree Properties Senior Advisor in cancer research. Ardmore, Pennsylvania Angelo, Gordon & Company LP Each year, a select few of our Fellows greatly exceed our New York, New York Thomas J. Fahey, Jr., MD very high expectations. To reward and encourage these young Senior Vice President for Clinical Program Richard J. O’Reilly, MD Alan M. Leventhal, Development Chair, Department of Pediatrics scientists—and to keep them focused on fighting cancer—we have Chairman Director, International Center Chief, Pediatric Bone Marrow Transplant Memorial Sloan-Kettering Cancer Center Service created the new Dale F. Frey Award for Breakthrough Scientists, New York, New York Claire L. Tow Chair in Pediatric Oncology CHAIRMAN Research named in tribute to our outgoing Chairman. Mr. Alan M. Leventhal Mr. Dale F. Frey Memorial Sloan-Kettering Cancer Center Chairman and CEO Retired Chairman of the Board and New York, New York Beacon Capital Partners, LLC President This funding will catapult the careers and research of up to three Boston, Massachusetts General Electric Investment Corporation Mrs. Katharine F. Plum Stamford, Connecticut Hobe Sound, Florida Fellows per year, providing $100,000 toward their research. More VICE CHAIRMAN, DEVELOPMENT AND COMMUNICATIONS Mr. John A. Fry Mr. Andrew S. Rachleff importantly, the award endorses each recipient as a next-generation Mr. David M. Beirne President President and Chief Executive Officer Aspen, Colorado Drexel University Wealthfront leader, helping to ensure that our very best stay in cancer research. Philadelphia, Pennsylvania Palo Alto, CA VICE CHAIRMAN, FINANCE AND TREASURER Elaine V. Fuchs, PhD Ms. Karen D. Seitz The first recipients were chosen in Fall 2010, after this Report went to print. Mr. Leon G. Cooperman Rebecca C. Lancefield Professor Managing Director Chairman and CEO Laboratory Head Fusion Partners Omega Advisors, Inc. The Rockefeller University New York, New York New York, New York New York, New York William R. Sellers, MD VICE CHAIRMAN, Richard B. Gaynor, MD Vice President & Global Head, Oncology BOARD DEVELOPMENT Vice President Novartis Institutes for BioMedical Research Mr. Michael L. Gordon Cancer Research and Clinical Investigation Cambridge, Massachusetts Chief Operating Officer Eli Lilly and Company Angelo, Gordon & Company LP Indianapolis, Indiana Samuel C. Silverstein, MD New York, New York John C. Dalton Professor 16 years of Ms. Margaret A. Gilliam Department of Physiology and VICE CHAIRMAN, President Cellular Biophysics SCIENTIFIC PROGRAMS Gilliam & Company Columbia University outstanding leadership David M. Livingston, MD New York, New York New York, New York Deputy Director Dale F. Frey Dana-Farber/Harvard Cancer Center Todd R. Golub, MD Emil Frei III Professor Director, Cancer Program As Chairman of the Board of Directors from 1993 to 2010, Dale Frey transformed the Harvard Medical School The Broad Institute of MIT and Harvard Damon Runyon Cancer Research Foundation into a world-class philanthropy. Under his Boston, Massachusetts Cambridge, Massachusetts leadership, the Foundation raised more than $160 million, launched three new award VICE CHAIRMAN, AUDIT AND CORPORATE Mr. Scott Greenstein programs, and funded the research of more than 850 exceptional young scientists. GOVERNANCE President Sanford W. Morhouse, Esq. Entertainment and Sports During this time, Damon Runyon scientists: Of Counsel Sirius XM Radio Inc. Dewey & Leboeuf LLP New York, New York New York, New York • Contributed to the development of three • Elucidated the process of programmed Mr. Jay W. Ireland new targeted therapies: Herceptin, Erbitux cell death President and CEO and Bexxar GE Asset Management • Cloned the first mice from adult stem cells Stamford, Connecticut •  Co-discovered the first breast cancer gene • Pioneered the field of RNA interference •  Used gene sequencing technology to • Discovered the link between HPV and predict response to treatment head and neck cancer

Most importantly, thanks to Dale’s leadership, the work of Damon Runyon scientists has transformed cancer medicine and will continue to save lives.

9. The Damon Runyon Cancer Research Foundation 10. 2010 annual report

Damon Runyon Fellowship Award Committee

Sankar Ghosh, PhD Lee A. Niswander, PhD Chair Silverstein and Hutt Family Professor of Investigator, Howard Hughes Medical Institute (11/09-11/10) Microbiology and Immunology Professor, Department of Pediatrics Rama Ranganathan, MD, PhD Chair, Department of Microbiology and Section of Developmental Biology Professor, Department of Pharmacology Immunology University of Colorado Denver Cecil H. and Ida Green Chair in Columbia University Aurora, Colorado Biomedical Science New York, New York Director, Green Center for Systems Biology Ramon E. Parsons, MD, PhD University of Texas Southwestern Medical R. Kiplin Guy, PhD Avon Foundation Professor of Pathology Center Chairman, Department of Chemical Biology and Medicine Dallas, Texas and Therapeutics Leader, Breast Cancer Program St. Jude Children’s Research Hospital Institute for Cancer Genetics Memphis, Tennessee Herbert Irving Comprehensive Cancer Center Vice Chair Columbia University (11/09-11/10) Thomas S. Hays, PhD New York, New York Daniel E. Gottschling, PhD Professor, Department of Genetics, Cell Member, Basic Sciences Division Biology and Development Norbert Perrimon, PhD Fred Hutchinson Cancer Research Center University of Minnesota Investigator, Howard Hughes Medical Institute Seattle, Washington Minneapolis, Minnesota Professor of Genetics Harvard Medical School Damon Runyon Victor R. Ambros, PhD Tyler Jacks, PhD Boston, Massachusetts Silverman Professor of Natural Sciences Investigator, Howard Hughes Medical Institute Program in Molecular Medicine Director, David H. Koch Institute for Amita Sehgal, PhD University of Massachusetts Medical School Integrative Cancer Research Investigator, Howard Hughes Medical Institute Worcester, Massachusetts David H. Koch Professor of Biology Professor, Department of Neuroscience Award Programs Ludwig Scholar University of Pennsylvania School of David P. Bartel, PhD Massachusetts Institute of Technology Medicine Investigator, Howard Hughes Medical Institute Cambridge, Massachusetts Philadelphia, Pennsylvania Damon Runyon Damon Runyon Professor of Biology Fellowship Award Clinical Investigator Massachusetts Institute of Technology David J. Julius, PhD Andrey S. Shaw, MD Supports the training of the Award Member Morris Herzstein Chair in Molecular Biology Investigator, Howard Hughes Medical Institute Whitehead Institute for Biomedical Research and Medicine Emil R. Unanue Professor of Pathology and brightest postdoctoral scientists Supports early career physician- Cambridge, Massachusetts Professor and Chair of Physiology Immunobiology as they embark upon their scientists conducting patient- University of California, San Francisco Department of Pathology and Immunology Lynn Cooley, PhD San Francisco, California Washington University research careers. The funding oriented research. The goal Professor of Genetics, Cell Biology and St. Louis, Missouri enables them to be mentored of this program is to increase Molecular, Cellular and Developmental Steven D. Leach, MD Biology Professor of Surgery, Oncology and Cell Brent R. Stockwell, PhD by established investigators in the number of physicians Department of Genetics Biology Associate Professor leading research laboratories capable of moving seamlessly Yale University School of Medicine McKusick-Nathans Institute of Genetic Department of Biological Sciences and across the country. between the laboratory and New Haven, Connecticut Medicine Department of Chemistry The Johns Hopkins University Columbia University Three-Year Award the patient’s bedside in search Benjamin F. Cravatt, III, PhD Baltimore, Maryland New York, New York Professor and Chair (stipend increased 1/10) of breakthrough treatments. Department of Chemical Physiology Guillermina (Gigi) Lozano, PhD Wilfred A. van der Donk, PhD The Skaggs Institute for Chemical Biology Mattie Allen Fair Research Chair Investigator, Howard Hughes Medical Institute Basic Scientists: $156,000 Three-Year Award Helen L. Dorris Institute for the Study of Professor and Section Chief Richard E. Heckert Professor of Chemistry Physician-Scientists: $186,000 $450,000 plus up to $100,000 Neurological and Psychiatric Disorders Department of Molecular Genetics Department of Chemistry for medical school loan The Scripps Research Institute M.D. Anderson Cancer Center University of Illinois, Urbana-Champaign La Jolla, California The University of Texas Urbana, Illinois Damon Runyon- repayment Houston, Texas Rachleff Frederick R. Cross, PhD Terry A. Van Dyke, PhD Professor Innovation Award Liqun Luo, PhD Chief, Mouse Cancer Genetics Program Continuation Grant Laboratory of Yeast Molecular Genetics Investigator, Howard Hughes Medical Institute Center for Cancer Research Supports the next generation Supports Damon Runyon The Rockefeller University Professor, Department of Biological Director, Center for Advanced Preclinical of exceptionally creative New York, New York Sciences Research Clinical Investigators who are Stanford University National Cancer Institute at Frederick thinkers with high-risk, high- approaching the end of their Andrew G. Dillin, PhD Stanford, California Frederick, Maryland reward ideas that have the Investigator, Howard Hughes Medical Institute original three-year awards and Associate Professor and Pioneer Philippa C. Marrack, FRS, PhD Johannes Walter, PhD potential to significantly impact Developmental Chair need extra time and funding to Investigator, Howard Hughes Medical Institute Associate Professor our understanding of and/or Molecular and Cell Biology Lab Member, Department of Immunology Department of Biological Chemistry and complete a promising avenue Salk Institute for Biological Studies approaches to the prevention, National Jewish Medical and Research Molecular Pharmacology of research or initiate/continue La Jolla, California Center Harvard Medical School diagnosis or treatment of cancer. Denver, Colorado Boston, Massachusetts a clinical trial. Robert N. Eisenman, PhD Member, Basic Sciences Division Three-Year Award David J. McConkey, PhD $450,000 Two-Year Award Fred Hutchinson Cancer Research Center Director of Urologic Research $300,000 Seattle, Washington Professor of Urology This program is possible through a Departments of Urology and Cancer Biology founding grant from Andrew and Debra This program is possible through the M.D. Anderson Cancer Center Rachleff, and the support of the Island support of the William K. Bowes, Jr., The University of Texas Outreach Foundation. Foundation, and Connie and Bob Lurie. Houston, Texas

11. The Damon Runyon Cancer Research Foundation 12. 2010 annual report

Damon Runyon Chuan-Hsiang Huang, MD, PhD Sujun Hua, PhD* Dong Yan, PhD* Harold L. Plotnick Fellow “Genomic analysis of core transcriptional Howard Hughes Medical “Adaptation and gradient amplification regulatory networks in normal and Institute Fellow Fellowship Awards in the chemotaxis signaling pathway” malignant neural stem cells” with Ronald “Building a kinase and phosphatase with Peter N. Devreotes, PhD, The Johns A. DePinho, MD, Dana-Farber Cancer network using phosphorylation signatures” Sabrina L. Spencer, PhD* Dale Muzzey, PhD* Hopkins University, Baltimore Institute, Boston with Norbert Perrimon, PhD, Harvard “Protein expression dynamics and Howard Hughes Medical Medical School, Boston California thresholds in cell cycle commitment” Institute Fellow Robin E. Stanley, PhD* Akinyemi I. Ojesina, MBBS, PhD Daniel H. Kim, PhD * with Tobias Meyer, PhD, Stanford “Resolving general principles of cis “Structural and biochemical characterization Rebecca Ridley Kry Fellow Alexandra Zidovska, PhD “Epigenetic regulation of X-chromosome University, Stanford translational regulation in eukaryotes using of the autophagy specific class 3 “Pathogen discovery and genomic “Cell division under confinement: exploring inactivation by noncoding RNAs” with high-throughput and mechanistic analyses phosphatidylinositol 3-phosphate complex” characterization of infection-associated mechanisms for cell division and volume Barbara J. Wold, PhD, California Institute Xiaomeng Milton Yu, PhD of allelic expression in Candida albicans” with James H. Hurley, PhD, National lymphomas” with Matthew Meyerson, MD, regulation” with Timothy J. Mitchison, PhD, of Technology, Pasadena “Investigating the mechanisms that with Jonathan S. Weissman, PhD, University Institute of Diabetes and Digestive and PhD, Dana-Farber Cancer Institute, Boston Harvard Medical School, Boston * determine localized axon degeneration of California, San Francisco Kidney Diseases, Bethesda Gabriel C. Lander, PhD during Drosophila mushroom body Eric J. Bennett, PhD Niels Bradshaw, PhD* MERCK FELLOW neuron pruning” with Liqun Luo, PhD, “Deubiquitylating enzymes as molecular “Regulation of the SpoIIE phosphatase “Structural roles of enzymes and substrates Avi Priel, PhD Stanford University, Stanford Massachusetts regulators of oncogenesis” with J. and activation of a cell-specific transcription in the construction of a microtubule platform “Looking for novel thermodetectors in the David G. Hendrickson, PhD* Wade Harper, PhD, Harvard Medical factor” with Richard M. Losick, PhD, that catalyzes APC-directed ubiquitination mammalian nervous system” with David “A guiding role for lincRNAs in the School, Boston Harvard University, Cambridge of spindle checkpoint proteins” with Eva Chitra V. Kotwaliwale, PhD J. Julius, PhD, University of California, San Howard Hughes Medical establishment of cancer-like epigenetic Nogales, PhD, Lawrence Berkeley National Francisco Institute Fellow landscapes” with John L. Rinn, PhD, Beth Jason M. Crawford, PhD William J. Greenleaf, PhD Laboratory, Berkeley “Regulation of meiotic chromosome Timothy O. Street, PhD Israel Deaconess Medical Center, Boston “Systematic approaches to discovering “Fluorogenic single-molecule fluorescence behavior in Caenorhabditis elegans” Connie and Bob Lurie Fellow bioactive bacterial metabolites” with enzymology” with X. Sunney Xie, PhD, Sharsti L. Sandall, PhD with Abby F. Dernburg, PhD, University Jon Clardy, PhD, Harvard Medical Harvard University, Cambridge “Mechanisms regulating maintenance of “Investigating the physical basis of of California, Berkeley School, Boston stem cells and the niche in Drosophila” substrate interaction with the HSP90 protein Yoh Isogai, PhD with D. Leanne Jones, PhD, Salk Institute chaperone” with David A. Agard, PhD, “Funding from Damon Dipali G. Sashital, PhD Harrison W. Gabel, PhD* “Molecular mechanisms of innate defensive for Biological Studies, La Jolla University of California, San Francisco Runyon allowed me “Biochemical and structural investigation “Dissecting the mechanism and function behaviors in rodents” with Catherine Dulac, of Piwi-interacting RNA biogenesis” Jesse Zalatan, PhD to stretch out into new of Arc regulation by the Angelman PhD, Harvard University, Cambridge Sarah E. Tully, PhD with Jennifer A. Doudna, PhD, University Syndrome-associated ubiquitin ligase Conrad Hilton Fellow “Elucidating the kinetic mechanism by areas and think about of California, Berkeley Ube3a” with Michael E. Greenberg, PhD, Josselin Milloz, PhD “A functional proteomic strategy to which a scaffold protein regulates MAPK things differently. That Harvard Medical School, Boston “Coordination of quiescence, meiosis and characterize endocannabinoid biosynthetic signaling” with Wendell A. Lim, PhD, * autophagy in the yeast Saccharomyces enzymes” with Benjamin F. Cravatt, III, Lara C. Skwarek, PhD University of California, San Francisco thinking led directly “In vivo identification of novel regulators Simon Jenni, PhD cerevisiae” with Sharad Ramanathan, PhD, PhD, The Scripps Research Institute, of epithelial-mesenchymal transition” to where we are today: Howard Hughes Medical Harvard University, Cambridge La Jolla with David Bilder, PhD, University of Colorado a new discovery in Institute Fellow California, Berkeley Jianfu (Jeff) Chen, PhD “Structural and functional studies of Melanie A. Samuel, PhD Sean C. Bendall, PhD the field of cancer-cell kinetochores” with Stephen C. Harrison, “Molecular basis of age-related synaptic “Improved single-cell phospho-protein Howard Hughes Medical Institute Fellow PhD, Harvard Medical School, Boston disorganization” with Joshua R. Sanes, signaling analysis of oncogenic Orkun Akin, PhD metabolism that has Howard Hughes Medical PhD, Harvard University, Cambridge progression in leukemia” with Garry P. “Epigenetic and cellular control of lung Institute Fellow Kristin A. Krukenberg, PhD* Nolan, PhD, Stanford University, Stanford development” with Lee A. Niswander, PhD, great “Live imaging of neuronal targeting in the University of Colorado Denver, Aurora Fayez Sarofim Fellow Sarah K. Bowman, PhD Drosophila visual system with 2-photon “The molecular mechanism of poly “Characterization of nucleosome Won-Suk Chung, PhD microscopy” with S. Lawrence Zipursky, (ADP-ribose) in the mitotic spindle” positioning in Polycomb-mediated gene “Phagocytic capacity of glial cells and therapeutic PhD, University of California, Los Angeles with Timothy J. Mitchison, PhD, Harvard repression” with Robert E. Kingston, PhD, their role in glioma progression” Connecticut Medical School, Boston Massachusetts General Hospital, Boston with Ben A. Barres, MD, PhD, Stanford Jelena Bezbradica, PhD potential.” Christopher J. Hale, PhD* University, Stanford Howard Hughes Medical Matthew G. Vander Heiden, MD, PhD Howard Hughes Medical Institute Fellow Young Kwon, PhD Ken S. Lau, PhD Institute Fellow Former Damon Runyon Fellow * “Molecular basis for transcription- “Identification and validation of new Robert Black Fellow Tom A. Hartl, PhD “Understanding how a histone Assistant Professor, MIT, Cambridge regulators in Hpo signaling” with Norbert “Elucidation of a novel signaling network “Serotonergic neuronal control of growth independent cytokine regulation of immune methyltransferase links DNA replication, Perrimon, PhD, Harvard Medical School, downstream of KRas in colorectal cancer” in Drosophila” with Matthew P. Scott, PhD, responses” with Ruslan M. Medzhitov, repair and transcription” with Steve E. Boston with Kevin M. Haigis, PhD, and Douglas Stanford University, Stanford PhD, Yale University, New Haven Jacobsen, PhD, University of California, A. Lauffenburger, PhD, Massachusetts Los Angeles † Costas A. Lyssiotis, PhD* John R. Lydeard, PhD* General Hospital, Boston Liana F. Lareau, PhD Oscar R. Colegio, MD, PhD Robert Black Fellow Amgen Fellow “Defining CRL4 substrates and regulators Howard Hughes Medical “Reversing the Warburg effect in through a systematic proteomic and Institute Fellow Christopher S. Campbell, PhD “Defining the role of the innate immune Taiowa A. Montgomery, PhD “Control of the chromosomal passenger basal-like breast cancer: a unique point functional analysis of DCAFs” with J. Wade “Mechanisms of microRNA-directed RNA “Global analysis of the role of 5’ system in tumor progression and complex by post-translational modification” for therapeutic intervention” with Lewis Harper, PhD, Harvard Medical School, silencing” with Gary B. Ruvkun, PhD, untranslated regions in the regulation of metastasis” with Ruslan M. Medzhitov, with Arshad B. Desai, PhD, University of C. Cantley, PhD, Beth Israel Deaconess Boston Massachusetts General Hospital, Boston translation” with Patrick O. Brown, MD, PhD, Yale University, New Haven California, San Diego Medical Center, Boston PhD, Stanford University, Stanford * Kristina M. Herbert, PhD Rebecca S. Mathew, PhD Carolyn M. Phillips, PhD Erhu Cao, PhD Alexandra M. Deaconescu, PhD Howard Hughes Medical Institute Marion Abbe Fellow Benjamin R. Myers, PhD Howard Hughes Medical “Structure and physiology of sensory Institute Fellow Howard Hughes Medical Fellow “Characterization of chromatin-associated “Analyzing the mechanism of Hedgehog TRP channels” with David J. Julius, PhD, Institute Fellow “Understanding the functions of the CLRC factors in small RNA pathways” with Gary signaling regulation by the Patched “Regulation and mechanism of pri-miRNA University of California, San Francisco “Elucidation of the mechanism of ubiquitin ligase/histone methylase complex B. Ruvkun, PhD, Massachusetts General protein” with Philip A. Beachy, PhD, processing by Drosha and DGCR8” transcription-DNA repair coupling” in heterochromatin formation” with Danesh Hospital, Boston Stanford University, Stanford with Joan A. Steitz, PhD, Yale University, Lee Stirling Churchman, PhD New Haven with Nikolaus Grigorieff, PhD, Brandeis Moazed, PhD, Harvard Medical School, * * Merck Fellow University, Waltham Boston Ian Y. Wong, PhD Jason A. Reuter, PhD “Visualizing global transcription in vivo Merck Fellow “Characterizing non-coding RNA at nucleotide resolution” with Jonathan Michael J. Emanuele, PhD Elizabeth S. Sattely, PhD “Suppressing cancer cell invasion and interactions with dominant regulators Illinois S. Weissman, PhD, University of California, Philip O’Bryan Montgomery, “Biosynthesis of covalent bonds between plasticity in 3D microenvironments” of neuronal differentiation” with Brian J. Yeh, PhD San Francisco Jr., MD, Fellow heteroatoms: mechanistic understanding with Mehmet Toner, PhD, and Daniel Irimia, Michael P. Snyder, PhD, Stanford “Determining how a conserved signaling “Identification and characterization for the development of novel therapeutics” MD, PhD, Massachusetts General University, Stanford network establishes cell fate asymmetry” Kimberley Evason, MD, PhD* † with Eric L. Weiss, PhD, Northwestern of proteins with altered stabilities in with Christopher T. Walsh, PhD, Harvard Hospital, Boston * “Hepatic stellate cell development and role University, Chicago response to DNA damage” with Stephen Medical School, Boston Volker Schweikhard, PhD in carcinogenesis” with Didier Y.R. Stainier, J. Elledge, PhD, Brigham and Women’s “A single-molecule study of factors TFIIS PhD, University of California, San Francisco Hospital, Boston Ilan Wapinski, PhD and TFIIF during transcriptional elongation Howard Hughes Medical by RNA polymerase II” with Steven M. Maryland * Xu Tan, PhD Institute Fellow Block, PhD, Stanford University, Stanford Gianna Elena Hammer, PhD Nicholas R. Guydosh, PhD Robert Black Fellow Howard Hughes Medical “Study of the BRCA1 A complex in DNA “Unraveling the costs and benefits of “Coordination of dendritic cell maturation Institute Fellow damage response” with Stephen J. gene expression on cellular growth” and immune responses by the ubiquitin “Genome-wide regulation and dynamics Elledge, PhD, Brigham and Women’s with Roy Kishony, PhD, Harvard Medical modifying enzyme A20” with Averil Ma, MD, of ribosome elongation” with Rachel D. Hospital, Boston School, Boston University of California, San Francisco Green, PhD, The Johns Hopkins University, Baltimore

13. The Damon Runyon Cancer Research Foundation 14. 2010 annual report Damon Runyon Fellowship Awards Damon Runyon-Rachleff (continued) Innovation Award Nadya Dimitrova, PhD Jared T. Nordman, PhD Committee Blount Family Fellow Howard Hughes Medical "The fellows chosen by “Functional characterization of the role of Institute Fellow p53-regulated lincRNAs in tumorigenesis” “Cell cycle control of DNA replication Damon Runyon often with Tyler Jacks, PhD, Massachusetts in metazoans” with Terry L. Orr-Weaver, go on to be world-class Institute of Technology, Cambridge PhD, Whitehead Institute for Biomedical Chair Todd R. Golub, MD Steven M. Larson, MD Research, Cambridge leaders in their fields. Ronald Levy, MD Investigator, Howard Hughes Medical Institute Chief, Nuclear Medicine Service Nikhil S. Joshi, PhD* I feel honored to join Chief, Division of Oncology Director of the Cancer Program of the Donna and Benjamin M. Rosen Chair in “Understanding the development and Alla A. Sigova, PhD their ranks and am Professor of Medicine Broad Institute Radiology function of regulatory T cells in an Robert Black Fellow Stanford University School of Medicine Charles A. Dana Investigator in Human Memorial Sloan-Kettering Cancer Center autochthonous mouse model of human “Genetic and epigenetic mechanisms Stanford, California Cancer Genetics New York, New York non-small cell lung cancer” with Tyler of maintaining the embryonic stem inspired to Dana-Farber Cancer Institute Jacks, PhD, Massachusetts Institute of cell identity” with Richard A. Young, Elizabeth H. Blackburn, PhD Associate Professor of Pediatrics Jacqueline A. Lees, PhD Technology, Cambridge PhD, Whitehead Institute for Biomedical match their Morris Herzstein Professor of Biology and Harvard Medical School Associate Director, David H. Koch Institute Research, Cambridge Physiology Boston, Massachusetts for Integrative Cancer Research Yimon Aye, PhD achievements.” Department of Biochemistry and Biophysics Ludwig Scholar Robert Black Fellow Sabrina L. Spencer, PhD University of California, San Francisco Rachel D. Green, PhD Professor of Biology “Investigations toward mechanistic Missouri Damon Runyon Fellow San Francisco, California Investigator, Howard Hughes Medical Institute Massachusetts Institute of Technology understanding of human ribonucleotide Ken Cadwell, PhD Stanford University School Professor, Department of Molecular Biology Cambridge, Massachusetts reductase -subunit-specific inhibition Lallage Feazel Wall Fellow of Medicine, Stanford David Botstein, PhD and Genetics by triapine” with JoAnne Stubbe, PhD, “Characterization of mice deficient in Director, Lewis-Sigler Institute for The Johns Hopkins University Dan R. Littman, MD, PhD Massachusetts Institute of Technology, autophagy protein ATG16” with Herbert Integrative Genomics Baltimore, Maryland Investigator, Howard Hughes Medical Institute Cambridge W. Virgin, IV, MD, PhD, Washington Anthony B. Evnin Professor of Genomics Helen L. and Martin S. Kimmel Professor University, St. Louis Jung-Min Kee, PhD Princeton University Linda G. Griffith, PhD of Molecular Immunology Robert K. Bradley, PhD Leo W. and Lilyan G. Cole Fund Fellow Princeton, New Jersey Director, Biotechnology Process Skirball Institute of Biomolecular Medicine “Investigating the splicing co-regulatory Tiffany A. Reese, PhD “Investigation of histidine phosphorylation Engineering Center New York University School of Medicine network” with Christopher B. Burge, PhD, “The immune response to latent gamma in histone H4 through synthetic protein Mark M. Davis, PhD S.E.T.T. Professor of Biological and New York, New York Massachusetts Institute of Technology, herpesvirus infection” with Herbert chemistry” with Thomas W. Muir, PhD, Investigator, Howard Hughes Medical Institute Mechanical Engineering Cambridge W. Virgin, IV, MD, PhD, Washington The Rockefeller University, New York Director of the Stanford Institute for Massachusetts Institute of Technology Kevan M. Shokat, PhD University, St. Louis Immunity, Transplantation and Infection Cambridge, Massachusetts Investigator, Howard Hughes Medical Daniel A. Heller, PhD* Stanford University School of Medicine Institute “Molecularly imprinted polymeric antibodies Oregon Stanford, California Greg Hannon, PhD Professor and Chair for tumor-targeted siRNA delivery” with New Jersey Sunny D. Gilbert, PhD Investigator, Howard Hughes Medical Institute Department of Cellular and Molecular Robert S. Langer, ScD, Massachusetts Björn F.C. Kafsack, PhD* “Mechanisms of RNA silencing selectivity” Napoleone Ferrara, MD Professor Pharmacology Institute of Technology, Cambridge Howard Hughes Medical with James C. Carrington, PhD, Oregon Genentech Fellow Cold Spring Harbor Laboratory University of California, San Francisco Institute Fellow State University, Corvallis Tumor Biology and Angiogenesis Cold Spring Harbor, New York San Francisco, California Adam G.W. Matthews, PhD “Density-dependent autocrine control Genentech, Inc. Fraternal Order of Eagles Fellow of gametocytogenesis in the virulent Christopher A. Johnston, PharmD, PhD South San Francisco, California Kenneth W. Kinzler, PhD Elizabeth Yang, MD, PhD “Defining the architecture of human DNA malaria parasite Plasmodium falciparum” Dennis and Marsha Dammerman Professor of Oncology and Director Director, Sickle Cell and replication origins” with Stephen P. Bell, with Manuel Llinás, PhD, Princeton Fellow Sanjiv Sam Gambhir, MD, PhD The Ludwig Center for Cancer Genetics Hemoglobinopathy Program PhD, Massachusetts Institute of Technology, University, Princeton “Implementation of a novel system in Director, Molecular Imaging Program and Therapeutics Associate Professor of Pediatric Cambridge Drosophila S2 cells for investigating Head, Nuclear Medicine Division The Johns Hopkins University Kimmel Hematology-Oncology asymmetric cell division” with Kenneth Professor of Radiology and Bioengineering Cancer Center Vanderbilt University Medical Center William Rodney Hardy, PhD New York E. Prehoda, PhD, and Chris Q. Doe, PhD, Stanford University School of Medicine Baltimore, Maryland Vanderbilt-Ingram Cancer Center “Elucidation of signal transduction Duncan J. Smith, PhD* University of Oregon, Eugene Stanford, California Nashville, Tennessee pathways controlling oncogene-induced Howard Hughes Medical senescence and their protective roles Institute Fellow against melanoma and breast cancer” with “Lagging strand synthesis and chromatin Tennessee Michael R. Green, MD, PhD, University of replication” with Iestyn Whitehouse, Matthew F. Calabrese, PhD Damon Runyon-Rachleff Massachusetts Medical School, Worcester PhD, Memorial Sloan-Kettering Cancer Howard Hughes Medical Institute Center, New York Fellow Innovation Award Elaine M. Youngman, PhD “Ubiquitin interactions with a novel ubiquitin Kenneth G. and Elaine A. Langone Jelena Nedjic, PhD* recognition motif” with Brenda A. Schulman, Fellow “Molecular mechanisms of leukemia PhD, St. Jude Children’s Research Hospital, “Analysis of the biogenesis and functions metastasis and tissue infiltration” with Iannis Memphis California Michigan Joshua C. Munger, PhD* of endogenous small RNAs in Aifantis, PhD, New York University School Sarkis K. Mazmanian, PhD Ivan Maillard, MD, PhD and “Elucidating mechanisms of oncogenic Caenorhabditis elegans” with Craig C. of Medicine, New York “Host-bacterial immunomodulation in the Yi Zhang, MD, PhD metabolic manipulation” at the University Mello, PhD, University of Massachusetts Utah development of cancer” at the California “Modulation of Notch signaling to of Rochester, Rochester * Medical School, Worcester Lu Bai, PhD Elizabeth M. Duncan, PhD Institute of Technology, Pasadena control graft-versus-host-disease and Suzanne and Bob Wright Fellow Howard Hughes Medical Institute preserve the anti-tumor activity of * Fellow * Meelad M. Dawlaty, PhD “Promoter architecture for genes in the Heather R. Christofk, PhD alloreactive T cells” at the University North Carolina “Deciphering the genetics and epigenetics G1/S regulon: rules governing nucleosome “Epigenetic regulation of cellular “Regulation of cancer metabolism” at the of Michigan, Ann Arbor David G. Kirsch, MD, PhD of glioblastomagenesis by direct in vitro positioning, noise, amplitude and regulation memory during planarian regeneration” University of California, Los Angeles “Transforming cancer therapy with reprogramming of glioblastoma multiforme in gene expression” with Frederick R. with Alejandro Sánchez Alvarado, PhD, molecular imaging” at Duke University progenitor cells” with Rudolf Jaenisch, Cross, PhD, and Eric D. Siggia, PhD, The University of Utah, Salt Lake City New York Medical Center, Durham MD, Whitehead Institute for Biomedical Rockefeller University, New York Massachusetts Raffaella Sordella, PhD* Research, Cambridge * Initial Award John L. Rinn, PhD Island Outreach Foundation Laura A. Banaszynski, PhD † Physician-Scientist “The functional roles of large intergenic Innovator Washington Daniel F. Jarosz, PhD Angelo Family Fellow non-coding RNAs in cancer” at the Beth “Characterization of Erlotinib resistant, Muneesh Tewari, MD, PhD Howard Hughes Medical “Investigating the role of histone variants Israel Deaconess Medical Center, Boston Mesenchymal and Metastatic (EMM) “Cancer detection in ‘pre-diagnosis’ Institute Fellow in determining cellular identity” with C. cells present in naïve lung tumors prior blood samples via exosome-associated “The influence of Hsp90 on the relationship David Allis, PhD, The Rockefeller University, Nathanael S. Gray, PhD to treatments” at Cold Spring Harbor small RNAs” at Fred Hutchinson Cancer between genotype and phenotype” New York “Identification of kinase substrates Laboratory, Cold Spring Harbor Research Center, Seattle with Susan L. Lindquist, PhD, Whitehead using selective irreversible crosslinkers” Institute for Biomedical Research, Erik W. Debler, PhD at the Dana-Farber Cancer Institute, Boston Cambridge Dale F. and Betty Ann Frey Fellow “Assembly and structure of the nuclear pore complex scaffold” with Günter Blobel, MD, PhD, The Rockefeller University, New York

15. The Damon Runyon Cancer Research Foundation 16. 2010 annual report Damon Runyon Damon Runyon Clinical Investigator Award Clinical Investigator Awards Committee N. Lynn Henry, MD, PhD* C. Ryan Miller, MD, PhD Connecticut Lilly Clinical Investigator Genentech Clinical Investigator Tobias J.E. Carling, MD, PhD* Chair Patricia A. Ganz, MD Leslie L. Robison, PhD “Pain processing pathway analysis “Genomics-driven drug development for Doris Duke-Damon Runyon Clinical in aromatase inhibitor-associated glioblastoma” with Charles M. Perou, PhD, Richard J. O’Reilly, MD Professor, Schools of Medicine and Member, St. Jude Faculty Investigator Chair, Department of Pediatrics musculoskeletal syndrome” with Daniel and Terry Van Dyke, PhD, University of Public Health Chair, Epidemiology and Cancer Control “Molecular genetics of endocrine tumor Chief, Pediatric Bone Marrow Transplant F. Hayes, MD, University of Michigan, North Carolina, Chapel Hill Director, Division of Cancer Prevention Associate Director for Cancer Prevention disease” with Richard P. Lifton, MD, PhD, Service Ann Arbor and Control Research and Control Cancer Center and Robert Udelsman, MD, MBA, Yale Claire L. Tow Chair in Pediatric Oncology Jonsson Comprehensive Cancer Center St. Jude Children’s Research Hospital University School of Medicine, New Haven Research University of California, Los Angeles Memphis, Tennessee Washington Memorial Sloan-Kettering Cancer Center Los Angeles, California Minnesota Elahe A. Mostaghel, MD, PhD New York, New York Louise C. Strong, MD Andrew L. Feldman, MD Genentech Clinical Investigator Illinois “Investigation of IRF4 as a therapeutic “Defining and exploiting molecular Philip D. Greenberg, MD Professor of Cancer Genetics Vu H. Nguyen, MD Frederick R. Appelbaum, MD Director, Immunology Program Sue and Radcliffe Killam Chair target in T-Cell Lymphomas” with Stephen mechanisms of androgen metabolism August M. Watanabe, MD, Clinical M. Ansell, MD, PhD, and Ahmet Dogan, for prostate cancer therapy” with Peter Director, Clinical Research Division Member, Fred Hutchinson Cancer Chief, Section of Clinical Cancer Genetics Investigator Member, Fred Hutchinson Cancer Research MD, PhD, Mayo Clinic, Rochester S. Nelson, MD, Fred Hutchinson Cancer Research Center M.D. Anderson Cancer Center “Organ-specific regulatory T cells as a Center Research Center, Seattle Professor of Medicine and Immunology The University of Texas targeted therapy for graft-versus-host Head, Division of Medical Oncology University of Washington Houston, Texas disease” with Thomas F. Gajewski, MD, University of Washington School of New Jersey Brian G. Till, MD* Seattle, Washington PhD, The University of Chicago, Chicago Medicine David A. Williams, MD Vassiliki Karantza, MD, PhD Pfizer Clinical Investigator Seattle, Washington Hedvig Hricak, MD, PhD Chief, Division of Hematology/Oncology “Autophagy as a therapeutic target in “Optimization of adoptive immunotherapy breast cancer treatment” with Robert for lymphoma using genetically modified Chair, Department of Radiology Director, Translational Research for Massachusetts Joseph R. Bertino, MD S. DiPaola, MD, UMDNJ/Robert Wood CD20-specific T cells” with Oliver W. Carroll and Milton Petrie Chair Children’s Hospital Boston Rachael A. Clark, MD, PhD Chief Scientific Officer Johnson Medical School, New Brunswick Press, MD, PhD, Fred Hutchinson Cancer Memorial Sloan-Kettering Cancer Center Dana-Farber Cancer Institute “Reversing immune evasion in human The Cancer Institute of New Jersey Research Center, Seattle New York, New York Leland Fikes Chair of Pediatrics squamous cell carcinomas of the skin” Interim Director, The Stem Cell Institute of Harvard Medical School with Thomas S. Kupper, MD, Brigham and New Jersey New York William G. Kaelin, Jr., MD Boston, Massachusetts Women’s Hospital, Boston University Professor of Medicine and Igor Matushansky, MD, PhD* Wisconsin Investigator, Howard Hughes Medical Pharmacology Gordon Family Clinical Kevin R. Kozak, MD, PhD* Institute Andrew T. Chan, MD, MPH UMDNJ-Robert Wood Johnson Medical Investigator Genentech Clinical Investigator Professor of Medicine “Molecular imaging of colorectal neoplasia” School “Implementing and imaging epigenetic “Radiosensitization with antiangiogenic Harvard Medical School with Charles S. Fuchs, MD, MPH, and New Brunswick, New Jersey Dana-Farber Cancer Institute based differentiation therapy for solid therapy” with Paul M. Harari, MD, University Ralph Weissleder, MD, PhD, Massachusetts tumors” with Carlos Cordon-Cardo, MD, of Wisconsin, Madison Boston, Massachusetts General Hospital, Boston David P. Carbone, MD, PhD PhD, Columbia University, New York Harold L. Moses Chair in Cancer Research Drew M. Pardoll, MD, PhD Ingram Professor of Cancer Research This award program is currently supported Director, Cancer Immunology Program Michigan Vanderbilt-Ingram Cancer Center North Carolina by founding sponsor Eli Lilly and Company Sidney Kimmel Comprehensive Cancer Ronald J. Buckanovich, MD, PhD Vanderbilt University William Y. Kim, PhD in addition to Genentech, Merck and Center “Tumor endothelial cells as a therapeutic Nashville, Tennessee Merck Clinical Investigator Company, Novartis Pharmaceuticals Seraph Professor of Oncology and diagnostic target in ovarian cancer” The Johns Hopkins University School of “Molecular determinants of clinical Corporation, Siemens Medical Solutions, with Daniel F. Hayes, MD, and Max response to EGFR inhibition in bladder Inc. and Pfizer, Inc. Dennis A. Carson, MD Medicine S. Wicha, MD, University of Michigan, Professor of Medicine cancer” with Charles M. Perou, PhD, Baltimore, Maryland Ann Arbor Director, Moores Cancer Center University of North Carolina, Chapel Hill * Initial Award University of California, San Diego David R. Piwnica-Worms, MD, PhD La Jolla, California Director, Molecular Imaging Center Professor of Developmental Biology and Bruce A. Chabner, MD Radiology Clinical Director Washington University School of Medicine Damon Runyon Massachusetts General Hospital Cancer St. Louis, Missouri Center Clinical Investigator Award Professor of Medicine Kornelia Polyak, MD, PhD Harvard Medical School Associate Professor of Medicine Continuation Grants Boston, Massachusetts Department of Medical Oncology Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts Andrea L. Cox, MD, PhD Colorado “Analysis and manipulation of cross New York Douglas K. Graham, MD, PhD reactive immune responses to partial Renier J. Brentjens, MD, PhD Michael D. Prados, MD, FACP Novartis Clinical Investigator escape mutation in chronic Hepatitis C Lilly Clinical Investigator Professor in Residence of Neurological “Novel biologically targeted therapy against virus infection” with Drew M. Pardoll, “Adoptive therapy of B cell leukemias with Surgery the Mer receptor tyrosine kinase in the MD, PhD, The Johns Hopkins University genetically modified autologous T cells” Charles B. Wilson, MD, Endowed Chair treatment of pediatric ALL” with James V. School of Medicine, Baltimore with Michel Sadelain, MD, PhD, Memorial Director of Translational Research in DeGregori, PhD, and Sue Gail Eckhardt, Sloan-Kettering Cancer Center, New York Neuro-Oncology MD, University of Colorado Denver, Aurora Department of Neurological Surgery Massachusetts University of California, San Francisco Washington San Francisco, California Catherine J. Wu, MD Maryland “Immune-targeted leukemia antigens Colleen S. Delaney, MD, MSc Patrick A. Brown, MD for eradication of CML stem cells” with Novartis Clinical Investigator Lilly Clinical Investigator Jerome Ritz, MD, Dana-Farber Cancer “Notch-mediated ex vivo expansion of “Translating FLT3 inhibition into improved Institute, Boston cord blood progenitors for hematopoietic outcome for high risk childhood leukemia” cell transplantation” with Irwin D. Bernstein, with Donald Small, MD, PhD, The Johns MD, and Frederick R. Appelbaum, MD, Fred Hopkins University School of Medicine, Hutchinson Cancer Research Center, Seattle Baltimore The Continuation Grant Program is supported by the William K. Bowes, Jr., Foundation, and Connie and Bob Lurie.

17. The Damon Runyon Cancer Research Foundation 18. 2010 annual report Thank you to our donors. The year in review Ways to give July 1st, 2009 – June 30th, 2010 We raised a record $7 million at an event HELP FUND BREAKTHROUGHS honoring our past Chairman, Dale Frey, IN YOUR WILL OR TRUST When you give to Damon Runyon, your donations directly fund When you remember the Damon Runyon to establish The Dale F. Frey Award for Cancer Research Foundation in your will top cancer scientists. Every new discovery they make is directly Breakthrough Scientists, which will or estate plan, you ensure that future linked to your support, and they, and we, are immensely grateful provide additional funding to the “best generations continue to see new advances for the generosity and dedication of all of our donors. This year, of the best” Damon Runyon Fellows. against cancer. There are planned giving The dinner, held at New York City's strategies that can provide tax benefits. through your donations, we were able to continue funding the Please contact us for details. most promising research and launch a new award to support Metropolitan Club, included a video tribute to Mr. Frey featuring NBC Nightly News SPONSOR A SCIENTIST and encourage the next generation of scientific leaders. anchor Brian Williams, Mayor Michael Sponsor an individual Damon Runyon Bloomberg and Donald Trump. scientist and play an active role in Dale F. Frey Tribute Event making breakthroughs happen. We will The Runyon 5K, a unique run/walk that name the award for you, your family, or in honor of someone you choose. All takes place inside Yankee Stadium, made sponsors are offered the opportunity to its debut in the same year the Yankees meet with their scientist. We also provide won the World Series. The event raised regular updates on their research. $300,000 and introduced thousands of new donors to the Foundation. Over ANNUAL AND MONTHLY GIVING We welcome all levels of donation, 2,000 people took part, including cancer whether it's a one-time gift or a monthly survivors, Damon Runyon scientists donation. You can donate by mail, by and exuberant Yankees fans. Thanks to phone, or by using our secure website, Walgreens, 24 Hour Fitness, WNBC 4 New www.damonrunyon.org. We also welcome securities. All donations are York, SIRIUS XM Radio and the New York tax-deductible and fund our research Post for sponsoring this successful event. programs.

Eli Lilly and Co., founding partner of TRIBUTES our Clinical Investigator Award, Make a donation in memory of someone, generously pledged an additional $2.25 or to commemorate a holiday, birthday, wedding, or special occasion. A tribute Clockwise from left: Betty Ann and Dale Frey and family; Dr. Sam Silverstein as a million to fund our prestigious Clinical Runyonesque character; Larry Bossidy and John Myers. Investigator Award, bringing its total letter will be sent on your behalf to the person you designate. commitment to this program to an unprecedented $30 million. This continued DAMON RUNYON Damon Runyon 5K at Yankee Stadium endorsement reflects the caliber of the BROADWAY TICKETS research being carried out by these Enjoy access to top ‘house’ seats at Broadway shows and support talented investigators. Thanks also to cancer research. Gift certificates Genentech, Merck and Co., Novartis are also available, and allow the Pharmaceuticals, Siemens Medical recipient to choose a show and date. Solutions and Pfizer Inc., for their support Call 212.455.0550, or visit of this vitally important program. www.damonrunyon.org/broadway.

Damon Runyon Broadway Tickets To learn more about ways to support the Damon Runyon Cancer Research continues to help support our overhead Foundation, contact us at 212.455.0500, or expenses, enabling us to give 100% of visit us at www.damonrunyon.org/donate all direct donations to cancer research. Thanks once again to the Shubert

Organization, Nederlander Productions, of donations Jujamcyn Theaters and Disney Theatrical 1fund0 cancer0 research.% Productions whose valued partnerships All administrative and fundraising make this program possible. expenses are paid through Damon Runyon Clockwise from left: The Runyon 5K Kids’ Fun Run; a runner on the warning track; Broadway Tickets and our endowment. participants in the Great Hall.

19. The Damon Runyon Cancer Research Foundation 20. 2010 annual report Fayez Sarofim Fellow *

Named Awards Kristin A. Krukenberg, PhD Clinical Investigators Innovators Harvard Medical School Gordon Family Clinical Island Outreach Foundation Boston, Massachusetts Investigator Innovator Igor Matushansky, MD, PhD Raffaella Sordella, PhD The following awards are funded by dedicated supporters Columbia University Lallage Feazel Wall Fellow * Cold Spring Harbor Laboratory of the Damon Runyon Cancer Research Foundation who have Ken Cadwell, PhD New York, New York Cold Spring Harbor, New York Washington University generously endowed an award in perpetuity or sponsored an St. Louis, Missouri August M. Watanabe, MD, * In perpetuity individual Damon Runyon scientist: Clinical Investigator Suzanne and Bob Wright Vu H. Nguyen, PhD The University of Chicago Fellow * Lu Bai, PhD Chicago, Illinois The Rockefeller University Fellows Conrad Hilton Fellow Rebecca S. Mathew, PhD New York, New York Amgen Fellow Sarah E. Tully, PhD Harvard Medical School Costas A. Lyssiotis, PhD The Scripps Research Institute Boston, Massachusetts Beth Israel Deaconess Medical Center La Jolla, California Boston, Massachusetts Dale Muzzey, PhD Howard Hughes Medical University of California, San Francisco Angelo Family Fellow Institute Fellows San Francisco, California Damon Runyon Advisors Laura A. Banaszynski, PhD Orkun Akin, PhD The Rockefeller University University of California, Los Angeles Jared T. Nordman, PhD The Damon Runyon Advisors act as special advisors to the Foundation in their areas of New York, New York Los Angeles, California Whitehead Institute for Biomedical expertise and are committed to expanding awareness about our important work to the Research next generation of supporters. Marion Abbe Fellow * Jelena Bezbradica, PhD Cambridge, Massachusetts Carolyn M. Phillips, PhD Yale University

Massachusetts General Hospital New Haven, Connecticut Jill E. Bargonetti-Chavarria, PhD Jeremy Lack, PhD John M. Olivieri Duncan J. Smith, PhD Associate Professor Vice-President Partner Boston, Massachusetts Memorial Sloan-Kettering Cancer Center Hunter College New Leaf Venture Partners White & Case LLP Matthew F. Calabrese, PhD New York, New York Robert Black Fellows St. Jude Children’s Research Hospital Michael J. Bossidy Henry Mannix III Annemarie Schoepfer Yimon Aye, PhD Memphis, Tennessee Ilan Wapinski, PhD Managing Director Vice President Senior Partner, Planning Massachusetts Institute of Technology Harvard Medical School JPMorgan Securities, Inc. Kelso & Company Ogilvy & Mather Worldwide Cambridge, Massachusetts Jianfu (Jeff) Chen, PhD Boston, Massachusetts University of Colorado Denver Deborah Clayman Gerald M. Marshall Marcel R. M. van den Brink, MD, PhD Oscar R. Colegio, MD, PhD Aurora, Colorado Dong Yan, PhD Clayman Family Foundation President and CEO Head, Division of Hematologic Oncology Amerimar Enterprises, Inc. Memorial Sloan-Kettering Cancer Center Yale University Harvard Medical School Erica K. Evans New Haven, Connecticut Alexandra M. Deaconescu, PhD Boston, Massachusetts Senior Vice President Gary Wolf Brandeis University Christine L. O’Donnell ING Investment Management Vice President and Senior Managing Director Gianna Elena Hammer, PhD Worcester, Massachusetts Rebecca Ridley Kry Fellow * Angelo, Gordon & Company, LP University of California, San Francisco Akinyemi I. Ojesina, MBBS, PhD Karen Fang Program Officer San Francisco, California Elizabeth M. Duncan, PhD Dana-Farber Cancer Institute Head of Cross Asset Foundation Advisory Services University of Utah Boston, Massachusetts Strategies & Solutions for Bank of America Merrill Lynch Ken S. Lau, PhD Salt Lake City, Utah Global Markets in the Americas Massachusetts General Hospital Kenneth G. and Elaine A. Langone Bank of America Boston, Massachusetts Nicholas R. Guydosh, PhD Fellow * The Johns Hopkins University Elaine M. Youngman, PhD Alla A. Sigova, PhD Baltimore, Maryland University of Massachusetts Medical School Whitehead Institute for Biomedical Worcester, Massachusetts Research Christopher J. Hale, PhD Cambridge, Massachusetts University of California, Los Angeles Connie and Bob Lurie Fellow * Premier Circle 2010 Los Angeles, California Timothy O. Street, PhD Blount Family Fellow University of California, San Francisco The Broadway Premier Circle is a group of committed Damon Runyon Broadway Tickets Nadya Dimitrova, PhD Kristina M. Herbert, PhD San Francisco, California Massachusetts Institute of Technology Yale University customers who have made a special donation in support of cancer research. The Premier Cambridge, Massachusetts New Haven, Connecticut Merck Fellows Circle offers members priority access to tickets and other benefits. Lee Stirling Churchman, PhD Ms. Sandye Berger Mr. and Mrs. James H. Kimenker Mr. and Mrs. Henry J. Singer Leo and Lilyan Cole Fund Fellow Daniel F. Jarosz, PhD University of California, San Francisco Bonni Curran, MD Mr. and Mrs. Gerald M. Marshall Mr. and Mrs. Kenneth M. Stabler Jung-Min Kee, PhD Whitehead Institute for Biomedical San Francisco, California The Rockefeller University Research Ms. Dorothy D'Amato Ms. Lisa McInerney Ms. Dina Treanor New York, New York Cambridge, Massachusetts Mr. and Mr. and Mrs. James Emanuele Mr. Charles H. Murphy III Mr. Scott Urdang Gabriel C. Lander, PhD Ms. Mary Ann Frenzel Mr. James K. Murray, Jr. Mr. and Mrs. Peter J. Wasserman Lawrence Berkeley National Laboratory Ms. Penelope P. Harris Mr. and Mrs. Ernest Scheller, Jr. Dennis and Marsha Dammerman Simon Jenni, PhD Berkeley, California Fellow * Harvard Medical School Christopher A. Johnston, PharmD, PhD Boston, Massachusetts Ian Y. Wong, PhD University of Oregon Massachusetts General Hospital Eugene, Oregon Björn F.C. Kafsack, PhD Boston, Massachusetts Discovery Society 2010 Princeton University Fraternal Order of Eagles Fellow * Princeton, New Jersey Philip O’Bryan Montgomery, Discovery Society members are valued supporters who have provided for the Damon Adam G.W. Matthews, PhD Jr., MD, Fellow * Runyon Cancer Research Foundation through planned gifts. These donations provide a Massachusetts Institute of Technology Chitra V. Kotwaliwale, PhD Michael J. Emanuele, PhD vital source of support and fuel future breakthroughs against cancer. Cambridge, Massachusetts University of California, Berkeley Brigham and Women’s Hospital Berkeley, California Boston, Massachusetts Ms. Elaine M. Addis Ms. Martha R. Nortner Mr. and Mrs. Arthur Walker Dale F. and Betty Ann Frey Fellow * Liana F. Lareau, PhD Ms. Ann K. Cote Mr. and Mrs. Ronald E. Parr Mr. and Mrs. William C. Hines Harold L. Plotnick Fellow Mrs. Phyllis Farleigh Mr. Seymour Rosenheck Mr. D.G. Mitchell Erik W. Debler, PhD Stanford University Chuan-Hsiang Huang, MD, PhD Mr. Rick J. Govern Ms. Phoebe H. Showers Ms. Mary Ann Frenzel The Rockefeller University Stanford, California The Johns Hopkins University Mrs. Rebecca R. Kry Mrs. Carol H. Stix Robert F. Fisher, PhD New York, New York Baltimore, Maryland Mr. and Mrs. Charles B. Marqusee Ms. Rose Vaccariello Mr. and Mrs. Leo LoFrisco

21. The Damon Runyon Cancer Research Foundation 22. 2010 annual report Donors to the Dale F. Frey Award for Our Contributors Breakthrough Scientists The Damon Runyon Cancer Research Foundation acknowledges the generosity and support of the many individual, corporate and foundation donors who The following donors have honored retiring Chairman Dale F. Frey and shown their ongoing supported our brilliant researchers through gifts to the Foundation from July 01, commitment to the Damon Runyon Cancer Research Foundation by generously donating .* a combined total of $7 million to fund the Dale F. Frey Award for Breakthrough Scientists. 2009 to June 30, 2010

LEADERSHIP CIRCLE PATRONS Thomas J. Fahey, Jr., MD $1,000,000 or more Richard B. Loynd/Interco Charitable Trust $1,000-4,999 $1,000,000 $15,000-$24,999 Ms. Sue Firestone David L. Lieb Foundation Elaine V. Fuchs, PhD Eli Lilly and Company Mr. and Mrs. Eugene Mandel Mrs. Margaret N. Allport Richard B. Gaynor, MD Terry and David Beirne Chilton Investment Company, Inc. Howard Hughes Medical Institute Mr. and Mrs. Henry Mannix III Ms. Velma M. Anderson Todd R. Golub, MD Leon & Toby Cooperman Foundation Mr. and Mrs. Michael DeDomenico Rachleff Innovation Fund Mr. and Mrs. David G. Marshall Apple Lane Foundation Mr. and Mrs. James Gould General Electric Company Dewey & LeBoeuf LLP Gordon H. & Karen M. Millner Family Mrs. Harriet Ballon Mr. Scott Greenstein Sally and Michael Gordon Sanford W. Morhouse, Esq. Foundation Ms. Barbara Balser Mr. William B. Harrison, Jr. Sherry and Alan Leventhal Ueberroth Family Foundation $100,000-999,999 Eugene & Mary Murphy Charitable Gift Mr. James Barton Mr. Thomas L. Holton Mr. and Mrs. Michael W. Wickham Fund Mr. and Mrs. Roger Bauman Mr. and Mrs. Christopher W. Kleinert INNOVATORS Robert Black Charitable Foundation Louis and Rachel Rudin Foundation, Inc. Mrs. Barbara Lieb Baumstein Mrs. Rebecca R. Kry William K. Bowes, Jr. Foundation SEFA of Maryland Terry and David Beirne $100,000-$999,999 SPONSORS Dr. and Mrs. Arthur B. Laffer, Sr. Estate of Mr. Barry M. Clayton Ms. Karen D. Seitz Sol & Margaret Berger Foundation $10,000-$14,999 Mr. and Mrs. Ralph R. Layman Genentech, Inc. Henry J. & Kathleen Singer Family Ms. Sandye Berger Angelo, Gordon & Co. Levy Family Philanthropic Fund Sally and Michael Gordon Foundation Mr. and Mrs. John R. Berkley John M. and Judy Hart Angelo Mr. Arthur S. Bahr Mr. and Mrs. Alan M. Lewis Independent Charities of America Charles Spear Charitable Trust Donald P. Biek, PhD Aurora Capital Group Mr. and Mrs. Michael J. Cosgrove The Lichtenberger Foundation Island Outreach Foundation Staley Family Foundation Mr. and Mrs. Bruce J. Bier Bossidy Foundation Mrs. Elizabeth Dater David M. Livingston, MD Sherry and Alan Leventhal Barbara & Peter Strauss Philanthropic BLL Foundation The Erlbaum Family Foundation Mr. and Mrs. Frank Doyle Anthony F. LoFrisco, Esq. Connie and Bob Lurie Fund Mr. and Mrs. James Brady Mr. and Mrs. Kenneth G. Langone Lorraine and Bill Egan Mr. James Michael Mara Merck & Company, Inc. The T.F. Trust Mr. William S. Brady Lilly USA, LLC Mr. and Mrs. Richard J. Ferris Mr. and Mrs. Gerald M. Marshall Novartis Pharmaceuticals Corporation Estate of George Trommer Mr. Max J. Budwick Mr. and Mrs. David G. Marshall Mr. and Mrs. John A. Fry Mr. Marc Meiches Pfizer, Inc. Tzedakah Foundation Judy Buechner Advised Fund Debra and Andrew S. Rachleff Mr. Dennis Kass Ms. Gerturde G. Michelson Siemens Corporation White Rose Mr. and Mrs. Frank M. Bumstead Levin Capital Strategies, LP Richard J. O'Reilly, MD Mr. and Mrs. Kwok S. Wong Mr. and Mrs. James Burrows DISCOVERERS Mr. and Mrs. Robert Lieber Palisade Capital Management, LLC Mr. and Mrs. Arthur B. Calcagnini $50,000-$99,999 Hon. and Mrs. Eugene Ludwig The Pauls Corporation $50,000-99,999 Mr. and Mrs. Patrick J. Callan Gary P. Naftalis, Esq./Kramer Levin Mr. and Mrs. Jack O. Peiffer $5,000-9,999 Mr. and Mrs. Fred L. Carroll Naftalis & Frankel LLP Mr. and Mrs. William L. Perocchi 24 Hour Fitness Worldwide, Inc. Angelo, Gordon & Co. Mr. Edward Cassel Mr. Denis J. Nayden Mr. and Mrs. Roy Plum John M. and Judy Hart Angelo Ms. Margaret A. Gilliam Mrs. Joellen Fisher Blount Mr. and Mrs. Alexander Chapro Mr. and Mrs. John D. Opie Mr. Ronald Pressman Howard Bayne Fund Mr. and Mrs. Jay Ireland Estate of Adrienne & Harry Chamberlain Ms. Sharon Charlton Mr. and Mrs. Robert P. Quinn Mr. and Mrs. Arthur V. Puccini Biogen Idec Pyramid Hotel Group Estate of Mrs. Frances V. Lesch Ms. Jill B. Ciporin Mr. Michael D. Robbins Mr. Peter E. Ricker The Channing Family Donald J. Trump Foundation, Inc. Select Equity Group Estate of Laurelia M. Clifford Ms. Karen D. Seitz Mr. Philip Alan Riordan Estate of Barbara Trace The Cooper Family Foundation, Inc. Mr. and Mrs. Jay L. Cohan Shamrock Holdings, Inc. Ms. Chris A. Davis and Mr. Lee Rosenberg Mr. and Mrs. James J. Costello Milton L. Cohen & Norma M. Cohen BENEFACTORS Ms. Sandra J. Horbach and Mr. David B. Rusate Ms. Dorothy D’Amato Family Foundation, Inc. $25,000-$49,999 Mr. Steven Skoler Mr. Robert D. Scinto $25,000-49,999 Estate of Edward & Bozena Etnyre Mr. and Mrs. Martin J. Cohen Mr. and Mrs. Thomas W. Strauss William R. Sellers, MD The Fine & Greenwald Foundation, Inc. Ms. Jessica M. Cohn Ms. Phoebe H. Showers The Channing Family Wachtell, Lipton, Rosen & Katz Barney Family Foundation Laura Hartenbaum Breast Cancer Mr. and Mrs. Patrick J. Conway Samuel C. Silverstein, MD Mr. and Mrs. James J. Costello Mr. Peter J. Worth Leon & Toby Cooperman Foundation Foundation, Inc. Mr. Fred Cooper Mr. Wayne T. Smith/Community Mr. and Mrs. Dennis D. Dammerman Estate of Rita Eisenberg Mr. and Mrs. Robert L. Harteveldt Mr. and Mrs. Michael J. Cosgrove Health Systems Betty Ann and Dale Frey Erlbaum Family Foundation Estate of Walter Tom Holmes Mr. and Mrs. Vincent Costa FRIENDS Mr. and Mrs. John R. Stafford General Electric Asset Management, Inc. Grand Aerie Fraternal Order of Eagles J.I. Foundation, Inc. Mr. and Mrs. Michael J. Crames up to $10,000 Mr. James D. Staley Mr. W. James McNerney/ Hettinger Foundation Wm Maidman Family, LP David Crystal, DDS Mr. and Mrs. James E. Studer Mr. and Mrs. Gerald M. Marshall The Boeing Company Sidney Altman, PhD Mrs. Julia R. Plotnick Ms. Mary L. Cunningham Craig B. Thompson, MD Mr. and Mrs. Warren K. Myer Mr. and Mrs. John H. Myers Mr. and Mrs. Robert J. Bass Estate of Marion E. Kempf Smith Ms. Bonni Curran, MD Mr. and Mrs. John H. Timmis Mr. and Mrs. Roy Plum The Nielsen Company, Inc. Mr. and Mrs. Eugene K. Bolton Walgreens Mr. Lawrence H. David Mr. and Mrs. Donald W. Torey Estate of Ms. Jean Rosenheck Pfizer, Inc. Mr. Thomas J. Bracken Dr. Davis and Dr. Chien Fund Tully Foundation Roberta & Ernest Scheller, Jr. Family Mr. and Mrs. Arthur Samberg Steven J. Burakoff, MD Mr. Herb Deuschel Mr. and Mrs. Robert C. Wright Foundation Mr. and Mrs. John F. Welch, Jr. William L. Carroll, MD $10,000-24,999 Estate of Mrs. Mignon A. Dorsey Stewart Senter, Inc. Copeland Consulting International, Inc. Dr. Craig A. Drill Ms. Suzy Sang Shechtman Dr. and Mrs. Stanley J. Dudrick Estate of Dale D. Barr Mr. Ronald Dubin Mrs. Mikell M. Smith Electric Insurance Company Mr. and Mrs. Steven H. Berg Mrs. Willis H. DuPont Bloomberg L.P. Mr. and Mrs. Kenneth M. Stabler Mr. and Mrs. Daniel Ebenstein Mr. and Mrs. Kevin T. Conway Mr. and Mrs. James D. Staley Mr. and Mrs. Paul Elliot Creative Dimensions Mr. John L. Tishman Mr. and Mr. and Mrs. James Emanuele Mr. and Mrs. Michael DeDomenico Daniel & Grace Tully Charitable Trust Alex Engardt Roofing & Siding Echlin Foundation The Turk Family Foundation Epsilon Rho Chapter of Delta Theta Tau Michael and Elisabeth Erlbaum Family Estate of Winifred Wiederkerr Sorority Those whose total lifetime giving to Damon Runyon is $100,000 or Foundation Mr. Peter C. Erichsen General Electric Foundation Mr. and Mrs. Steven H. Erlbaum more are highlighted. We are especially grateful to these extraordinarily Estate of Elsinore Machris Gilliland Mr. and Mrs. Robert B. Eveleigh generous and committed donors. Irma T. Hirschl Charitable Trust Mr. Michael D. Fascitelli ING Foundation Stanley H. & Theodora L. Feldberg Fund

* Our donor lists are checked carefully. However, if you have any corrections or questions, please call 877.722.6237. The full pledge amount is listed in the year the pledge is made. In subsequent years, actual pledge payments are listed.

23. The Damon Runyon Cancer Research Foundation 24. 2010 annual report Our Donors (continued)

Mr. and Mrs. Samuel M. Feder Joe & Pasena Maroun Family Mr. Marvin C. Schwartz Mrs. Roberta Fine Foundation Trust Mr. Robert Schwartz Financial Summary, Fiscal Year 2010 Mr. Harold Foonberg Mr. and Mrs. Charles B. Marqusee Marvin & Donna Schwartz Foundation Mr. Ronald Forster Mrs. William Matheson Robert J. Seifer Cancer Research As in previous years, the financial activities of the Damon Runyon Cancer Mr. Harris Freedman The August Mattheyses Fund of the Foundation Freeport-McMoRan Foundation Community Foundation of New Jersey William R. Sellers, MD Research Foundation were audited by McGladrey and Pullen, LLP. For our complete Betty Ann and Dale Frey Ms. Lisa McInerney Mr. and Mrs. Theodore M. Serure audited financial statements, please visit our website atwww.damonrunyon.org . Mr. and Mrs. Robert W. Garthwait, Sr. Michael and Valerie McKeever Charitable ShareASale Mr. and Mrs. John J. Gasparovic Fund The Sidewater Family Foundation, Inc. Ms. Janet Gelbart Mr. John McStay Mr. and Mrs. Glen Siegel Ms. Margaret A. Gilliam Medical Research Charities Mr. and Mrs. Jerome A. Siegel Gleason-Leary Foundation MEFA of Baltimore Samuel C. Silverstein, MD Ms. Lois Goldring Mrs. Janet Menn Edwards Estate of Lidie Anne Smith Overall Financial Health–Summary of Balance Sheets Goldstone Fund, Inc. Mr. and Mrs. Martin E. Messinger Estate of Mildred A. Smith The Damon Runyon Cancer Research Foundation remained fiscally strong in Ms. Elizabeth A. Gray The Messinger Foundation, Inc. The Richard C. and Theresa P. Smith Patrick William Gray, PhD Dr. and Mrs. Milton A. Meyers Memorial Fund FY 2010. Thanks to our donors, our revenues grew, enabling us to expand our The Great Urban Race Mr. and Mrs. Fred A. Middleton Ms. Marsha M. Sterling scientific program funding. Mr. and Mrs. Vernon Grizzard Dunlevy Milbank Foundation, Inc. Mrs. Linda B. Stern Mrs. Joyce Groussman Mr. and Mrs. Jack D. Miller Bruce W. Stillman, PhD, FRS Mr. and Mrs. H. Patrick Hackett Jr. Mr. Joel Miller Martha Washington Straus - Harry Straus Mr. and Mrs. David Lee Hamilton Ms. Laura Miller Foundation, Inc. 2009 2010 Mr. I.H. Hammerman, II Morgan Stanley Employee Contributions Philip & Lynn Straus Foundation, Inc. Harold K. Raisler Foundation Estate of Helene G. Mourlanne Ms. Joanne Tate Total Assets 82,223,404 92,257,373 Mrs. Margaret Brennan Hassett Mr. Charles H. Murphy III Mr. and Mrs. Sanford V. Teplitzky Mr. and Mrs. James Hasso Ms. Kimberly Terk Murphy Carol Colman Timmis Foundation, Ltd. Total Liabilities 15,249,307 15,513,605 Lenore Hecht Foundation, Inc. Mr. and Mrs. W. Stephen Murray Mr. Andrew E. Tomback and Richard B. Herstine Mr. James K. Murray, Jr. Ms. Sally Strauss Total Net Assets 66,974,098 76,743,768 Mr. and Mrs. Robert M. Hess Mr. and Mrs. John H. Myers Mr. Joseph G. Tompkins Mr. and Mrs. R. Lee Hite Ms. Robin Nagle Mr. and Mrs. John M. Trani Mr. and Mrs. Lawrence C. Hoff Dr. and Mrs. Herbert E. Natof Ms. Dina Treanor Mr. and Mrs. Edward E. Hood Jr. Mr. and Mrs. Thomas J. Neff Mr. Porter Trimble Mr. and Mrs. Daniel Huber Mr. Roy R. Neuberger Truist Mr. Patrick M. Hurless and Ms. Megan New England Rugby Referees Society Mr. Scott Urdang K. Curran-Hurless Mr. Kevin E. Noonan and Ms. Cheryl Visa GivingStation Mr. and Mrs. Jay Ireland Steiger Jean H. & John T. Walter, Jr. Fund Mr. Thomas C. Israel The Octagon Fund Wasserman Foundation Where Our Money Where Our Support Johnson & Johnson Dr. Steven Olszewski Norman & Vivian Weiden Johnson-Miller Foundation Mrs. William J. Oppenheim Foundation, Inc. Goes—Summary of Comes From Mr. and Mrs. Stephen Joseph Mr. and Mrs. Gregory Z. Parker Mr. Stephen Winston Operating Expenses JS Philanthropic Fund Mr. and Mrs. Ronald E. Parr Mr. and Mrs. Rod C. Wood Mr. and Mrs. James H. Kimenker Mr. Gerald L. Parsky XTO Energy, Inc. General Mr. and Mrs. Douglas M. Kinney Mr. Stephen Patterson H.R. Young & Betty G. Young Fund Administration Klingenstein Fund Pauls Operations, Inc. Robert C. Young, MD Draw from Investments Ms. Cindy Kramer Mr. Steven S. Payson 5.4% Mr. and Ms. Jeremy R. Kramer Ms. Roberta Pearlberg Misc. Income Estate of Marie Kronman Ms. Agnes Peelle 12.4% Fundraising Mr. and Mrs. William L. Kronthal Pells Mayton Foundation, Inc. Donated Services Mr. and Mrs. Stig A. Kry Mr. Earl Potter Mr. and Mrs. John Lancaster Mr. Gerald Rauch Damon Runyon Ms. Janice R. Lane Remy Cointreau USA, Inc. Broadway Tickets Mr. and Mrs. Kenneth G. Langone Mr. and Mrs. Herman L. Rij Bequests and Trusts Mrs. Tova Leidesdorf Mr. and Mrs. D. Paul Rittmaster 82.2% Award Programs Mrs. Ann R. Lermer Mr. Leandro P. Rizzuto Levy Family Philanthropic Fund Rockefeller Financial Services Contributions Estate of Franklin S. Lewis Mr. and Mrs. Gary R. Rockhold The Lichtenberger Foundation Mr. George Rohr David M. Livingston, MD Ronson Family Philanthropic Fund Ms. Robie E. Livingstone Ms. Joan Rosenbaum LKC Foundation William & Jane Rosenau Foundation Mr. and Mrs. Christopher J. Lockwood Fund Mr. Carl M. Loeb III Mrs. Miriam K. Rothenberg Mr. and Mrs. J. Donald Longenecker Dr. and Mrs. John W. Rowe Mr. Richard H. Maidman Ms. Judith M. Rudderow total Operating Expenses Total Operating Revenue Mr. James H. Manges The Harry & Sally Sacks Foundation Mr. and Mrs. Joseph Mannello Mr. Ronald Sanders $11.8 million $17.52 million Mr. Frank L. Mansell Sanderson Family Charitable Fund Estate of Marion Manuel Dr. Lief Sannen and Mr. Larry Wieman Mr. Norman R. Schlanger Mr. Robert J. Schmier Mendon F. Schutt Family Fund

25. The Damon Runyon Cancer Research Foundation 26. 2010 annual report

“The generous support provided by the Damon Runyon Fellowship was instrumental in keeping me in cancer research at a time in my career when it was a personal and financial struggle for me to stay in science. I will always be grateful.” Matthew L. Meyerson, MD, PhD Professor of Pathology Dana-Farber Cancer Institute Harvard Medical School

“The Damon Runyon Clinical Investigator Award is THE reason that I stayed and pursued an academic career in cancer research. Indeed, the award was a turning point in my career. It gave me the protected time to develop my research, and the funding to start a new population-based case-control colon genetic epidemiology study. Without the support from Damon Runyon, it would be impossible for a junior investigator to launch an ambitious project like this. ” Li Li, MD, PhD Associate Professor Case Comprehensive Cancer Center Case Western Reserve University

“The Damon Runyon Fellowship really propelled my career forward and I am enormously grateful—it was the best thing that happened to me as a young, up-and-coming scientist. When I was funded by Damon Runyon in the early 1990’s to study basic aspects of mitochondria as a postdoc, it was not clear how my research was connected directly to cancer. Now, in my own lab, we have an NIH-funded project to study this exact connection. In other words, I was not a cancer researcher then, but through the support of Damon Runyon at that critical juncture, I am one now.” Gerald S. Shadel, PhD Professor Departments of Pathology & Genetics Yale University School of Medicine

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