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Vanderbilt Export Compliance Vanderbilt Export Compliance Export Control: Restricted Biological Agents Both the Export Administration Regulations (EAR) and the International Traffic in Arms Regulations (ITAR) have provisions for the control of biological agents. The control level is different depending on which regulations control the material. If you work with any of the following or similar agents and/or you intend to send samples or data abroad or plan to collaborate with foreign colleagues either within the United States or in foreign countries, please contact Vanderbilt Export Compliance (http://www.vanderbilt.edu/exportcompliance/ or email [email protected]). We will help you determine what restrictions apply to the agents in your lab and how to incorporate the export control requirements into your research program. What biological agents are restricted? Below is a list of agents restricted for export by the U.S. Department of Commerce. Be aware that this list is not exhaustive but is limited to biological agents likely to be used at Vanderbilt and have export control restrictions. These listed items are controlled for export regardless of quantity or attenuation, genetic elements or genetically modified organisms for such agents or “toxins”, including small quantities or attenuated strains of select biological agents or “toxins” that are excluded from the lists of select biological agents or “toxins” by APHIS, CDC, or DHHS. NOTE: Genetic elements from any of the below are also controlled. Specifically, any nucleic acid sequences which code for biological toxins, any nucleic acid sequences that are a hazard to human health when transcribed or translated, or any nucleic acid sequence that would make any restricted microorganism above more pathogenic. This also covers microorganisms that have been genetically altered to express the above genetic elements. 1. Any agent on the Select Agent List found here: http://www.selectagents.gov/SelectAgentsandToxinsList.html 2. Additionally, any item on the following list from the Department of Commerce: Bacteria Clostridium baratii, botulinum Rickettsia prowasecki Bacillus anthracis neurotoxin producting strains (Rickettsia prowazekii) Brucella abortus Clostridium botulinum Salmonella typhi Shiga toxin production Escherichia coli (STEC) of serogroups O26, O45, O103, O104, O111, O121, O145, O157, and other shiga toxin Clostridium butyricum, botulinum producing serogroups Brucella melitensis neurotoxin producting strains NOTE: Shiga toxin producting Escherichia coli (STEC) is also known as enterohaemorrhagic E. coli (EHEC) or verocytotoxin producing E. coli (VTEC) Clostridium perfringens, epsilon toxin Brucella suis Shigella dysenteriae producing types Burkholderia mallei Coxiella burnetii Vibrio cholera (Pseudomonas mallei) Burkholderia pseudomallei Francisella tularensis Xanthomonas albilineans (Pseudomonas pseudomallei) Xanthomonas axonopodis pv. Citri Chlamydophila psittaci Mycoplasma mycoides (Xanthomonas campestris pv. citri A) (formerly Chlamydia psittaci) See Commerce Control List for details (Xanthomonas capestrispv. citri) Page 1 Revised February 2017 Vanderbilt Export Compliance Bacteria Continued Clavibacter michiganensis subspecies sepedonicus Ralstonia solanacearum, race 3, Xanthomonas oryzae pv. oryzae (Corynebacterium michiganensis sub biovar 2 See Commerce Control List for details species sepedonicum or Corynebacterium sepedonicum) Clostridium argentinense botulinum Raythayibactor toxicus (formerly Clostridium botulinum Type Yersinia pestis See Commerce Control List for details G), neurotoxin producing strains Fungi Magnaporthe oryzae Puccinia striiformis Coccidioides immitis (Pyricularia oryzae) (Puccinia glumarum) Microcyclus ulei Coccidioides posadasii Sclerophthora rayssiae var. zeae (Dothidella ulei) Cochliobolus miyabeanus Peronosclerospora philippinensis Synchytrium endobioticum (Helminthosporium oryzae) (Peronosclerospora sacchari) Colletotrichum kahawae Phoma glycinicola (Colletotrichum coffeanum var. (formerly Pyrenochaeta glycines) – Tilletia indica virulans) See Commerce Control List for details Purccinnia graminis ssp. graminis var. graminis/Puccinia graminis ssp. graminis var. stakmanii Thecaphora solani (Puccinia graminis [Puccinia graminis f. sp. tritici]) Toxins Abrin HT-2 toxin T-2 toxin Microcystin Aflatoxins Tetrodotoxin (Cyanginosin) Verotoxin and other Shiga-like Botulinum toxins Modeccin toxin ribosome inactivating proteins Viscum album Lectin 1 Cholera toxin Ricin (Viscumun) Clostridium perfringens toxins Saxitoxin Volkensin toxin Conotoxin Shiga toxin Staphylococcus aureus enterotoxins, hemolysin alpha toxin, and toxic Diacetoxyscirpenol toxin shock syndrome toxin (formerly Staphylococcus enterotoxin F) Page 2 Revised February 2017 Vanderbilt Export Compliance Viruses African horse sickness virus Hantaan virus Peste des petits ruminants virus Hendra virus Porcine enterovirus type 9 African swine fever virus (Equine morbillivirus) (Swine vesicular disease virus) Porcine herpes virus (Aujeszky's Akabane virus Influenza virus disease) Andean potato latent virus Japanese encephalitis virus Potato spindle tuber viroid (Potato Andean latent tymovirus) Andes virus Junin virus Powassan virus Pulmonary and renal syndrome- Avian influenza (Al) viruses identified haemorrhagic fever viruses as having high pathogenicity (HP) Kyasanur Forest virus (Seoul, Dobrava, Puumala, Sin See Commerce Control List for details Nombre) Reconstructed replication competent forms of the 1918 pandemic influenza Avian influenza virus Laguna Negra virus virus containing any portion of the coding regions of all eight gene segments Bluetongue virus Lassa fever virus Rift Valley fever virus Camel pox virus Louping ill virus Rinderpest virus Central European tick-borne encephalitis viruses Lujo virus Rocio virus (Absettarov, Hanzalova, Hypr, Kumlinge) Cercopithecine herpes virus 1 Lumpy skin disease virus Sabia virus (Herpes B virus) SARS-associated coronavirus Chapare virus Lymphocytic choriomeningitis virus (SARS-CoV) Chikungunya virus Lyssa virus (a.k.a. Rabies) Seoul virus Choclo virus Machupo virus Sheep pox virus Congo-Crimean haemorrhagic fever virus Malignant catarrhal fever virus St. Louis encephalitis virus (Crimean-Congo haemorrhagic fever virus) Swine fever virus Coronavirus Marburg virus (Hog cholera virus) Dengue fever virus Menangle virus Teschen disease virus Tick-borne encephalitis virus (Far Eastern subtype, formerly known Dobrava-Belgrade virus Monkey pox virus as Russian Spring-Summer encephalitis virus, Siberian subtype, formerly West Siberian virus) Eastern equine encephalitis virus Morbillivirus Tyomovirus Ebola virus Murray Valley encephalitis virus Variola virus Enterovirus Newcastle disease virus Venezuelan equine encephalitis virus Foot and mouth disease virus Nipah virus Vesicular stomatitis virus Goat pox virus Omsk haemorrhagic fever virus Virusmdashsee Guanarito virus Oropouche virus Western equine encephalitis virus Yellow fever virus Page 3 Revised February 2017 Vanderbilt Export Compliance Page 4 Revised February 2017 .
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