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DEPARTMENT OF June 16,1958, Vol. X, No. 12 PUBLIC HEALTH SERVICE HEALTH. EDUCATION, AND WELFARE NATIONAL INSTITUTES OF HEALTH DR. BURNEY ELECTED OSCAR" AWARDEDNCI COLLECTS RECORDS PRESIDENT OF W.H.O. OF CANCER PATIENTS Dr. Leroy E. Burney, Surgeon Case histories of thousands of General, PHS, was unanimously cancer patients are being compiled elected president of the World Health by NCI to provide a statistical basis Organization at its 11th annual as­ for evaluating cancer treatments and sembly in Minneapolis May 30. to learn more about rare forms of Dr. Burney, who is 51, began pre­ the disease. siding immediately after his elec­ Reports on 500,000 patients are tion. He is the chief U. S. delegate being submitted to NCI this year by to WHO. approximately 200 hospitals A commissioned officer in PHS throughout the country. The Cancer since 1932, Dr. Burney was Deputy Chemotherapy National Service Chief of the Bureau of State Services Center, NCI, is collecting the re­ before he became Surgeon General ports and will receive information on in August 1956. 50,000 new patients a year. When correlated, the data will provide NCI scientists with a basis Science Teachers Gain for comparing the results of chemo­ Dr. C. J. Van Slyke poses with his surprise Research Experience award, the "Van Oscar." (See story, page 4.) therapy with radiation and surgery in treating cancer. In NIH Laboratories Contracts totaling $223,812 have Seventeen high school science NIAMD COLLABORATES IN been awarded to 10 large medical teachers are gaining practical re­ STUDY OF RARE DISEASE institutions and five central regis­ search experience at NIH this sum­ tries. The registries are collecting mer as part of a work-study insti­ A clinical study of Reiter's dis­ data from 190 hospitals participating tute sponsored by American Uni­ ease, a rare malady often mistaken in the study. versity. for rheumatoid arthritis, has been For the third y-ar, science teach­ undertaken by NIAMD in cooperation Dr. Field Honored ers from all ove»* ti 9U. S. have been with Walter Reed Army Hospital. assigned to NIH laboratories where The study will utilize advanced For Diabetes Work they are assisting in phases of re­ tissue culture techniques in an at­ The 1958 Lilly Award will be pre­ search for an eight-week period. tempt to isolate the cause of the dis­ sented to Dr. James B. Field, Clini­ Lectures and supervised laboratory ease. If this can be done, it may of­ cal Endocrinology Branch, NIAMD, studies at American University are fer important clues about the cause at the 18th meeting of the American also part of the work-study program. of rheumatoid arthritis. Diabetes Association June 21-22 in While at NIH, the teachers have an Reiter's disease is seen most fre­ San Francisco, Calif. The annual opportunity to observe the latest re­ quently in military personnel and award, consisting of $1,000 and a search techniques and to gain ex­ may be infectious. Present evidence medal, is supported by Eli Lilly and perience that will enable them to suggests that either a bacterial or Company to recognize outstanding stimulate student interest in sci­ viral agent may cause the disease. research in the field of diabetes. ence. Intensive bacteriologic and viro- Dr. Field has devoted his energies An orientation program for the logic studies are being conducted on to diabetes research since he joined science teachers will be held here selected patients transferred to the the NIH staff in 1954. He is cur­ June 23. Talks and films will intro­ CC from Walter Reed Army Hos­ rently engaged in postdoctoral stud­ duce them to the organization and pital. ies at King's College Hospital, Lon­ functions of NIH and PHS. The cooperative study is being di­ don, and will return to NIH in August. The teachers institute is sup­ rected by Dr. Joseph Bunim, Clini­ A 1951 graduate of Harvard Medi­ ported by the National Science Foun­ cal Director, NIAMD, and Gen. cal School, Dr. Field has recently dation. It is administered at NIH by Thomas Mattingly, Chief of the De­ been concerned with the problem of the Clinical and Professional Educa­ partment of Medicine, Walter Reed insulin antagonism in diabetic aci­ tion Branch, CC. Army Hospital. dosis. Silver-Staining Zecknique Publication Preview

The following manuscripts were received by No. 207 in a Series the 5RB Editorial Section between March 26 and April 10. histological study of normal and de­ generative changes was generally OD disappointing. Dublin, T. D. Looking ahead in epidemiology. Dr. Rasmussen's method, which was developed with the patient as­ DBS Eddy, B. E.; Stewart, S. E.;and Berkeley, W. sistance of research technician Edna Cytopathogenicity in tissue cultures by a tumor P. McCrane, has certain advantages virus from mice. that make it unique among staining processes. The synaptic substance DRG Hill, R. T. Paradoxical effects of ovarian in the terminal endings can be seen secretions. for the first time. The nonneuro- fibrillar components of the synapse are far more voluminous than for­ Severinghaus, J. W., and Bradley, A. F. Elec­ merly suspected. Almost the entire trodes for blood 0„ and CO„ determination.

surface of the nerve cell is thickly NCI encrusted with the tiny buttons. Birnbaum, S. M.; Greenstein, M. E.; Wtnitz, M.; Though the physical chemistry of and Greenstein, J. P. Quantitative nutritional silvering of nervous tissue is still studies with water-soluble, chemically defined diets. VI. Growth studies on mice. poorly understood, it is known that Cook, J. S., and Blum, H. F. Dose relationships the site of silver deposition is and oxygen dependence in ultraviolet and photo- The black particles around this nerve cell greatly influenced by pretreatment dynamic hemolysis. Elkind, M. M., and Sutton, H. Sites of action are the silvered synaptic substance in the of the tissue with a suitable fixative of lethal irradiation overlap in sites for x-ray, terminal endings. and an effective mordant. The mor­ ultraviolet, photoreactivation and ultraviolet dant, in this stain, is the substance protection and reactivation in dividing yeast that makes the fixed tissue receptive cells. At long last, after experimenta­ to silver. Gamble, D. F. Chemical activities and publi­ tion with 40 or 50 modifications, The chief ingredient of Rasmus­ cations of the Public Health Service. Dr. Grant L. Rasmussen, Chief, Heller, J. R. Cancer and the outlook. sen's formula, and the most essen­ Landau, B. R.; Levine, H. J.; and Hertz, R. Section on Functional Neuroanat­ tial, is a solution of potassium di- Prolonged glucagon administration in a case of omy, NINDB, has achieved a satis­ chromate. The other ingredients are hyperinsul ini sm due to disseminated islet cell factory method of demonstrating solutions of chloral hydrate and sil­ carcinoma. synaptic endings in the central nerv­ ver combined with a solution of so­ Milmore, B. K. Influence of calendar years of observation and age distribution upon survival of ous system. dium thiosulfate. The high degree of patients with chronic diseases. A methodolog­ Despite many difficulties, Dr. silver selectivity achieved with the ical note. Rasmussen has arrived at a silver new stain, as depicted above, is ob­ Smith, R. R. Alteration of growth and spread impregnation method that stains the tained by the use of protargol, which of experimental and human cancer. synaptic substance surrounding the is silver combined with protein. Vilar, 0., and Hertz, R. The postnatal histo­ genesis and endocrine function of abnormal neuron without staining the cell's A section of treated tissue is de­ testes associated with urinary tract anomaly in fiberlike components and likewise veloped in a silver gelatin as if it the AXC rat. without coloring the mitochondria were a photographic negative. When Weisburger, J. H.; Wei sburger, E. K.; and known to populate the cell itself as the proper stage of development is Morris, H. P. Differences in the metabolism of N-2-fluorenylacetamide in the guinea pig and the well as its terminals. reached, the areas where the synap­ rat. Dr. Rasmussen's highly selective, ses are found are seen as dark re­ Westfall, B. B.; Evans, V. J.; Peppers, E. V.; and extremely reliable, silver- gions against a yellowish background Hawkins, N. M.; Bryant, J. C; Schilling, E. L.; staining formula avoids the density of fibers and cells. The synaptic and Earie, W. R. Observations on the metabolic endings are darkest of all. If more behavior of a clone of mouse liver cells grown .n of color that in the past has tended agitated fluid suspension. to emphasize cell body and cell fi­ background detail is desired, the tis­ bers and to complicate study of the sue is gold toned and slightly warmed NH1 synapse by obscuring the presence of overnight. For some unknown rea­ Bragdon, J. H. On the composition of chyle the synaptic terminals. son, the heat seems to change the chylomicrons. background hue to rose and the color Chen, P. S., Jr. Liquid scintillation counting Like all silver-staining tech­ of C14and H3 in plasma and serum. niques, the new one must be handled of the terminals to deep blue or Dayton, P. G.; Eisenberg, F., Jr.; and Burns, with care. purple. J. J. Studies on intermediary metabolism of Many neurological difficulties, Already applied to hearing and L-ascorbic acid in guinea pigs. Dethier, V. G., and Bodenstein, D. Hunger in ranging from malfunction of the sight research in NINDB and to the blowfly. brain to the explosive reactions that widely diversified investigations of Maling, H. M., an6 Highman, B. Exaggerated accompany strychnine poisoning, the synapse in the United States and ventricular arrhythmias an6 myocardial fatty occur when the nervous impulse fails elsewhere in the world, the use of changes after large doses of norepinephrine and to cross the synapse properly. Rasmussen's stain will further epinephrine in unanesthetized dogs. Ross, J., Jr. Transeptal left heart catheteriza­ Traditional staining methods ac­ knowledge of the interneural con­ tion: A new method of left atrial puncture. centuated the fibrillar network nections in the central and periph­ Sanders, R. J., and Morrow, A. G. The local­ stemming from the cell, but unfor­ eral nervous systems. Hopefully, it ization of circulatory shunts with inhaled kryp­ 85 tunately produced only faintly visible may lead to a better understanding of ton . A preliminary clinical report. how the brain functions. Udenfriend, S., and Waalkes, T. P. On the outlines of the synapse. As a result, I role of serotonin in anaphylaxis. NIAID Rurch, T. A.; Rees, C. W.; and Kayhoe, D. B. MM Spotlight NEWS BRIEFS Laboratory and clinical studies on vaginal trichosomiasis. Mrs. Luke I. Wilson was recently Ernmons, C. W. Saprophytic reservoirs of named "Outstanding Senior Citizen histoplasma. of the Year in Montgomery County" NIAMD by the Woman's Club of Bethesda. Altland, P. D., and Thompson, E. C. Some At a ceremony in her honor, Mrs. factors affecting blood formation in turtles. Wilson was presented with a scroll Federman, D.; Robbins, J.; and Rail, J. E. Some observations on cretinism and its treatment. by PHS Surgeon General Leroy E. Kirkman, H. N., and Kalckar, H. M. Enzymo- Burney, in appreciation other dona­ logical studies on congenital galactosemia. tion of land to NIH. Lerner, E. M. II, and Haas, V. H. Histopa= ***** thology of lymphocytic choriomeningitis in mice Dr. Norman Topping, former As­ spared by amethopterin. Sokoioff, L. Designated discussion: The role sociate Director of NIH, was re­ of mycobacteria in allergic manifestations. cently named president of the Uni­ Tobie, E. M., and Highrnan, B. Failure to versity of Southern California. Dr. demonstrate cerebral lesions in rabbits infected Topping, who was commissioned in with Trypanosoma gambiense. PHS inl936, wasakey member of the Yielding, K. L., and Tomkins, G. M. Effects of adrenal steroids on glucose oxidation by rat Alexander Mclnnes NIH staff for 12 years. He received liver homogenates. his A.B. and M.D. degrees from the University of Southern California. NIDR •if. if. if. if. if. Ifaer, P. N.; Goldman, H. M.; and Scigliano, J. "Ask the man who owns one" --or Studies on a bacitracin periodontal dressing. owns two or three, or even six. A military pay bill authorizing a Geever, E. F.; Leone, N. C; Geiser, P.; and Alexander Mclnnes is the man who $576 million pay increase for the Lieberman, J. Pathologic studies in man follow­ believes in the old Packard slogan. uniformed services, including PHS ing prolonged ingestion of fluoride in drinking Ten years ago he owned six antique Commissioned Officers, was signed water. by President Eisenhower last month. Russell, A. L., and White, C. L. Fluorides Packards at one time. Now he and periodontal health. makes do with a mere two, plus a The pay increases became effective pre-war Mercedes Benz and a new June 1 and will be reflected in the NIMH Austin Healey. June 30 pay checks. Mvord, E. C, Jr., and Kies, M. W. Experi­ ***** mental "allergic" encephalomyeliti s. Alex, who is a laboratory general Brinley, F. J., Jr.; Kandel, E. R.; and Marshall, mechanic in the Laboratory of Tech­ Dr. Harry Eagle, Chief of the Sec­ W. H. The effect of intravenous D-tubocurarine nical Development, NHI, was bitten tion on Experimental Therapeutics, on the electrical activity of the cat cerebral by the automobile bug in 1937. He NIAID, recently presented the 11th cortex. lived in London then, and spent a annual Jack H. Tritt Memorial Lec­ Calhoun, J. B.; Casby, J. U.; and Brant, D. ture at Jewish Hospital, St. Louis, The calculation of home range and density of year of spare time restoring a well- small mammal s. worn MG. From there he went onto Mo. He spoke on "Amino Acid Me­ Cole, J. 0. The clinical research program of old Rolls Royces and Bentleys. tabolism in Tissue Culture." the Psychopharmacology Service Center. The six-Packard phase came after Deasy, L. C. Some problems in conducting re­ search with families of psychiatric patients. the war, when Alex moved to the Fraser, H. F., and Isbell, H. Human pharma­ United States. By that time he was NIH Families Eligible cology and addiction liability of certain com­ thoroughly infected with the antique pounds related to morphine or codeine. car virus. His present posses­ For Red Cross Blood Goodrich, D. W. The choice of situation for sions -- a 1932 Packard convertible observational studies of children. NIH employees and members of Isbell, H. Clinical research on addiction in roadster, a 1937 Packard victoria, their immediate families who need the United States. and a classic 1936 Mercedes Benz -- blood may arrange for it directly Marshall, W. H. Temporal periodicities in the are housed in two garages in the Dis­ through the Montgomery County primary projection system. trict, where Alex restores them to Chapter of the Red Cross. Szara, S.; Axel rod, J.; and Perl in, S. Is perfect running condition, and lov­ adrenochrome present in the blood? If blood is needed, call JUniper Wikler, A. Opiates and opiate antagoni sts. ingly polishes them to looking-glass 8-2515 and give the name of the luster. proposed recipient and of the hos­ NIMDB Alex is one of a dedicated horde Greenfield, J. G.; Common, T.; and Shy, G. M. pital in which he is a patient. The The prognostic value of the muscle biopsy in the of Americans who have the same Red Cross will then complete the floppy infant. enthusiasm. He's a member of the arrangements, according to the Lab­ Kaufman, H. E. Primary familial amyloidosis. Antique Auto Club of America, for oratory of Blood and Blood Products, Li, C. Effect of sensory nerve stimulation owners of cars over 25yearsold; the on the activity of pyramidal neurons in the motor NIH. cortex. Classic Car Club, whose members own the one-of-a-kind or custom- Alex feels that the work he does on built models; the Mercedes Benz the cars is closely allied and benefi­ NIH RECORD Club; and for a spot of variety, the cial to the work he does at NIH, where Sports Car Club. his technical engineering skill has Published by Over the Memorial Day weekend, contributed to the construction of Scientific Reports Branch Alex traveled through Maryland and such prosthetic devices as the heart- Division of Research Services Pennsylvania attending sports-car lung oxygenator and the heartvalve. National Institutes of Health and antique-car rallies, and brought But don't look on the parking lot for Room 212, Building 8 home two trophies to add to the six cars with the classic styling of the Bethesda 14, Maryland previously awarded for his restora­ 1930's -- Alex comes to work the OLiver 6-4000 Ext. 2125 tions. modern way, in his Austin Healey. "CO-STEP" PROGRAM SURPRISES HIGHLIGHT NIH AWARDS CEREMONY UNDER WAY AT NIH Students from accredited profes­ sional schools all over the U. S. are arriving at NIH to begin a tour of "training duty" as reserve officers in the PHS Commissioned Corps. This year, 57 promising students with advanced medical, dental, or scientific training have been se­ lected to participate in the Commis­ sioned Officer Student Training and Extern Program, known as CO- STEP. While furthering their pro­ fessional knowledge by working with NIH scientists, they will become familiar with research activities and opportunities in Government health agencies. Dr. Van Slyke (right) congratulates award-winni Clarence N',ay, but gives the check to Mrs. May The CO-STEP program, offered Surprises were the keynote of by PHS for about ten years, has been NIH's Annual Awards Ceremony, at TWO EMPLOYEES RETIRE an effective means of recruiting pro­ which 21 employees were honored. fessional personnel for careers in For the first time in NIH's history, AFTER LONG SERVICE the PHS Commissioned Corps. In bagpipe music echoed through the CC Homer E. Greenfield and Eugene past years, many of the accepted Auditorium, as the "Kilties" of the Dernay, both long-time Government students have been employed at 2nd Army Pipe and Drum Corps employees, retire from service this NIH. Positions are carefully filled piped Scottish tunes. month. to benefit both students and sci­ Dr. C. J. Van Slyke, NIH Associate Mr. Greenfield has been with the entists. Director, who was back at his post as Government almost continuously for Scientists interested in employing Master of Ceremonies, was the 44 years, and served with the Army CO-STEP students may contact the author of one surprise and the recip­ during World War I. A management Clinical and Professional Education ient of another. analyst in the Office Services Branch, Bg. 10, Rm. 13N-228, ext. When Dr. Van Slyke presented a Branch, DBO, he has held adminis­ 3381. deserved superior performance trative positions at NIH since 1953. award to Clarence W. May, Special Previously he was employed at the Consultant, DRS, he called Mrs. May War Manpower Commission, the So­ DR. HELEN DYER RECEIVES to the podium and presented the cial Security Board, and the Federal check to her. Security Agency. ACHIEVEMENT AWARD Later in the ceremony the tables Mr. Dernay, a native of Hungary, Dr. Helen M. Dyer, Laboratory were turned when Dr. VanSlykewas has been a translator in the Scien­ of Biochemistry, NCI, was one presented with a surprise "Van tific Reports Branch, DRS, since of two persons to receive an Oscar" award for "sustained valor 1948. Prior to that time he served alumni achievement award from and superior performances" as as a translator for the Post Office George Washington University on master of ceremonies at NIH awards Department. In addition to his native June 4. Dr. Dyer was honored programs. Hungarian, Mr. Dernay translates for her "notable achievement in Another well-kept secret was re­ German and French, and is familiar biochemical research in the field vealed when Dr. Van Slyke presented with most other European languages. of cancer." a superior performance award to Representative Brooks Hays, of Daniel G. Rice, Information Special­ Arkansas, was also honored. ist, DRS, who was unaware he was to Mr. Kieley To Attend Dr. Dyer has been concerned receive it. with the mechanism of action of Brussels Congress chemical carcinogens since she Dr. Enomoto Dies James F. Kieley, Information Of­ came to NIH in 1942. At present Dr. Takayuki Francis Enomoto, an ficer, NCI, has accepted an invita­ she is investigating the compound NIH Visiting Scientist, lost his life tion to attend the First World Con­ N-2-fluorenylacetamide and its de­ in a boating accident on the Potomac gress of Public Relations in Brus­ rivatives. When administered orally River on May 30. He had conducted sels, Belgium, this month. Mr. to a rat, this compound induces clinical studies in neurophysiology Kieley, who is chairman of the NIH cancers in body tissues. These in the Surgical Neurology Branch, Information Training Committee, is studies may indicate the biochemi­ NINDB, for the past year. contributing a paper entitled "In- cal changes that play a role A native of Japan, Dr. Enomoto service Training for Information in the conversion of normal to came to the U. S. in 1953 and com­ Specialists in Medical Science and malignant cells. pleted four years of resident training Health." Dr. Dyer taught biochemistry at in neurosurgery at the Georgetown After the Brussels meeting, Mr. George Washington University, University Medical Center. He is Kieley will attend the Seventh Inter­ where she received her M.S. and survived by his parents, brothers, national Cancer Congress, tobe held Ph.D. degrees. and sisters, who live in Japan. in London July 6 through' 12.

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