Letter from the President, January 2012 ALOHA! Phytochemistry and Related Sub-Dis- Ciplines Forward

PSNA News Phytochemical Society of North America Sociedad Fitoquímica de América del Norte Société Phytochimique de L’Amerique du Nord Volume 50, Number 1 January 2012 Letter from the President, January 2012 ALOHA! phytochemistry and related sub-dis- ciplines forward. It is my pleasure Hello to all continuing members to serve as president of the Society and to the wealth of new members during its 50th anniversary year. that joined at our 50th Anniversa- I first joined the PSNA in 1985 ry meeting this past December in and attended the conference in Pa- Kona, Hawaii. This was a significant cific Grove, CA (Asilomar) which milestone for our group that started was also my first professional con- out as the Plant Phenolics Group of ference. It was a wonderful experi- North America in 1961 and changed ence and I was pleased with the re- its name to the Phytochemical So- ception of my short talk. Including ciety of North America on January 1985, I have attended 20 of the 27 1, 1967. PSNA has a rich history of meetings and am always impressed hosting excellent meetings cover- with the science, the networking op- ing all aspects related to plant con- portunities, and the attention paid to stituents and for moving the field of younger members. ... continues on page 4

In this issue: Getting ready for for the 2012 meeting, review of the 50th!

This is the printed version of the PSNA Newsletter. The web PDF version can be downloaded from the website: www.psna-online.org.

PSNA News Page 1 January 2012 PSNA News The PSNA EXECUTIVES January 2012 Phytochemical President Cecilia A. McIntosh, Ph.D. Society of Dean, School of Graduate Studies Professor, Biological Sciences North America East Tennessee State University Burgin Dossett Hall Room 309K The Phytochemical Society of North PO Box 70720 America (PSNA) is a nonprofit Johnson City, TN 37614-0720 scientific organization whose 423-439-4221 (telephone) membership is open to anyone with CONTENTS [email protected] Presidents Letter … 1 an interest in phytochemistry and the President Elect Toni Kutchan, Ph.D. 2012 PSNA Meeting … 3 role of plant substances in related Member, Oliver M. Langenberg 2011 Business Meeting … 4 fields. Annual membership dues are U.S. $60 for regular members and Distinguished Investigator, 2011 Neish Awards … 6 VP for Research, 50th Anniversary Meeting … 8 $30 for student members. Annual meetings featuring symposium Danforth Center Dr. Eric Conn … 11 975 N. Warson Rd. topics of current interest and St. Louis, MO 63132 contributed papers by conference 314-587-1473 WWW.PSNA-ONLINE.ORG participants are held throughout the [email protected] United States, Canada, and Mexico. Past President PSNA meetings provide participants Charles Cantrell, Ph.D. with exposure to the cutting-edge USDA-ARS, Natural Products research of prominent international Utilization Res. Unit scientists, but are still small P.O. Box 8048 enough to offer informality and University, MS 38677 USA intimacy that are conducive to the 662-915-5898 (phone) [email protected] exchange of ideas. This newsletter is Secretary circulated to members to keep them Eric Johnson, Ph.D. informed of upcoming meetings and Crop Bioprotection Research developments within the society, and USDA-ARS-NCAUR to provide a forum for the exchange 1815 N. Univeristy St. of information and ideas. If you Peoria, IL 61604 USA would like additional information 309-681-6177 (phone) about the PSNA, or if you have [email protected] material that you would like included Treasurer in the newsletter, please contact the Danile Owens, Ph.D. Natural Products Utilization Research PSNA Secretary or visit our website USDA-ARS at www.psna-online.org. Annual P.O. Box 8048 dues and changes of address should University, MS 38677 ADVISORY COUNCIL be sent to the PSNA Treasurer. Also 662-915-1039 (phone) check the PSNA website for regular [email protected] Daniel Owens (2 year term) updates. Editor-in-Chief, RAP [email protected] The PSNA is an all volunteer David R. Gang, Ph.D. organization which depends on its Associate Professor and Fellow Fred Stevens (2 year term) Institute of Biological Chemistry [email protected] membership to run the organization. We appreciate the time and effort Washington State University P.O. Box 646340 Mark Bernards (3 year term) these volunteers are putting in Pullman, WA 99164-6340 [email protected] to keep the organization up and 509-335-0586 (phone) running. As a member, please [email protected] Norman Lewis (3 Year Term) consider volunteering to serve on [email protected] one of these committees. The PSNA can always use more help! PSNA News Page 2 January 2012 Save the dates! PSNA 2012 will be held Aug. 11-15 on the campus of The University of Western Ontario, in London, Ontario, Canada.

Following close on the heels of Getting to London is easy! It is The organizing committee is the very successful 50th anniversary situated less than 200 km West of made up of: Mark A. Bernards, meeting in Hawaii, the 51st PSNA Toronto and 200 km East of Detroit, Committee Chair, (University of meeting program will include a along the trans Canada Highway Western Ontario), John T. Arnason broad range of topics of interest to (Hwy 401), and boasts an interna- (University of Ottawa), Charles all PSNA members. Main sympo- tional airport (YXU), serviced by Cantrell (USDA, ARS), Vincenzo sia topics include Metabolism/Me- two daily United Airlines’ flights DeLuca (Brock University), Mark tabolomics, Botanicals/Medicinals, from Chicago. Air Canada (via Air R. Gijzen (Agriculture & Agri-Food Ecological relevance of Phytochem- Jazz) operates several daily flights Canada), Toni Kutchan (Donald icals, Biosynthesis, and Phytochem- between Toronto and London, while Danforth Centre), and Cecilia ical Applications. The program will WestJet has direct flights from Cal- McIntosh (East Tennessee State be filled in with contributed talks gary. University) selected from submitted abstracts. Excursions to Niagara Falls, and Poster session round out the pro- a winery tour are being planned. See you in London! gram. A call for abstracts will be announced in early February, with a submission deadline of May 30, 2012. Early Bird Registration will open in February, and close May 30, University of Western Ontario (www.uwo.ca) 2012. The final day for registration Department of Biology (www.uwo.ca/biology/) will be July 31, 2012. Registration City of London (http://www.londontourism.ca/ fees are inclusive of most meals (ex- cludes only two dinners), including Tourism Ontario (www.ontariotravel.net) the awards banquet. PSNA News Page 3 January 2012 ... continues from page 1 Dr. Wendy Boss, MCB Program Di- PSNA Business Meeting The 50th anniversary meeting set rector at the U.S. National Science Dec 14, 2011 a record for student and postdoc Foundation for a special session on Cecilia McIntosh travel support and for poster partici- “Funding Opportunities for Interna- pation and awards. Norman Lewis tional Collaborations”. The PSNA members business obtained funding from the U.S. De- This newsletter is filled with meeting was called to order by Pres- partment of Energy which helped wonderful details and photos from ident Charles Cantrell on December with travel support for 10 students the 50th anniversary meeting. Plans 14, 2011 at 5:15 pm. Dr. Cantrell and postdocs and I was able to ob- for the 2012 meeting are well under- reported on attendance at the Ex- tain funding from the U.S. National way. Be sure to save the dates and ecutive Committee meeting held Science Foundation to provide sup- make plans to attend the 2012 meet- on December 10, 2011 (Cantrell, port for 19 undergraduate students, ing in London, Ontario, Canada (see Gang (editor-in-chief of RAP), and graduate student, and pre-tenure notice in the newsletter) and be sure McIntosh were present, Owens was women Ph.D.’s. These grants, added to keep your eye open for upcoming present to report on Young Members to the travel funds that the PSNA email notices. Committee and to represent trea- contributes each year to students One of the things we will be do- surer Dayan, Fred Stevens and Toni through the Loewus Travel Grants ing this next year is working on an Kutchan were present by invitation; and to postdoctoral researchers, electronic membership directory. Secretary Pedras was absent) and on meant that a record number of early You can help us by going online to topics discussed at the meeting: cur- career folks were able to attend the update your contact information by rent meeting issues (awards, judges, conference. These awards, added going to this website: http://psna. banquet agenda, finances/grants), the to the poster presentation awards, uhhconferencecenter.com/?page_ Recent Advances in Phytochemistry Neish Young Investigator Awards, id=878. Series, Treasurers report, treasurer Phytochemistry Pioneer awards, and One of the better features will and secretary elections, website, PSNA Lifetime award resulted in 50 be to include information on your newsletters, and future meetings. awards being presented at the annual research interests. We will include Reports on each topic are included banquet! that information as a way to help in the minutes of the business meet- We heard many excellent talks everyone be able to easily find those ing. and viewed many excellent posters. with similar research interests and Results of the election for vice The Neish Young Investigator sym- to help facilitate contacting poten- president were announced and Toni posia were excellent and we want tial collaborators. Please see the at- Kutchan will serve as vice president to thank all speakers for their con- tached form and return to the trea- starting at the close of the business tributions. We also want to thank surer, Daniel Owens, either by snail meeting. She will assume the presi- the Young Members Committee for mail or by email (his address is on dency at the close of the members’ hosting two professional develop- page 2 of this newsletter) if you have business meeting at the 2012 confer- ment lunches, “Finding a Graduate not already done so. Thank you! ence in London, Ontario. Having Program” and “Grantsmanship”. only one nominee each for treasurer The session on “Grantsmanship” Cecilia McIntosh and secretary, McIntosh made a mo- was especially well-attended and we East Tennessee State University tion to accept the nominees by accla- want to thank all panel members and Johnson City, TN USA mation. The motion was seconded participants. Special thanks also to [email protected]

Past-President Charles Cantrell President Cecilia McIntosh President-Elect Toni Kutchan PSNA News Page 4 January 2012 by Sanja Roje and received unani- postdocs, and pre-tenure women port on the current 50th Anniversary mous support of all members in at- were awarded this year! Charles meeting in Hawaii which set an attendance. New treasurer is Daniel Cantrell reported on a grant he has tendance record for the Society, Owens and new secretary is Eric pending that, if funded, may result with nearly 500 in attendance. He Johnson. in opportunity for additional travel stated thanks to the local hosts and In the absence of Franck Dayan, reimbursements. Due to the large the team from the University of Hilo Daniel Owens gave the treasurer’s number of posters in the best poster Conference Center, led by Judith [email protected] or Ce- competition this year (over 80), the Fox-Goldstein. A full reporting on lia McIntosh at [email protected]. committee established 4 divisions the conference will be ready on the In absence of Mark Berhow, and 6 awards: undergraduate (1 usual calendar of 2-4 months af- Charles Cantrell gave the Website award), master’s students (1 award), ter the end of the conference. The Committee report. The committee is doctoral students (2 awards), and members at the meeting thanked composed of Mark Berhow (chair) postdoctoral researchers (2 awards). Norman for chairing the organizing and Desmond Slade. The commit- The committee experimented with a committee and scientific committee tee is very responsive to updates, job new judging rubric this year and it for this conference. postings, etc. The committee asks was very successful. The committee Celia McIntosh and Toni Kutchan members to contact Mark immedi- stated their thanks to the large num- reported briefly that they were in ately at [email protected] ber of anonymous judges that donat- discussions with Tom Clark from El- if they have something to post, see ed their time to this important pro- sevier, who attended the conference, something that needs updating, or fessional development opportunity. regarding potential mechanisms to find an error. David also asked that the committee strengthen and formalize the inter- Newsletter Committee is chaired be expanded to 4-5 members in or- actions between the PSNA and El- by the Society Secretary. Other der to facilitate the judging process sevier and to increase the visibility members are Mark Berhow, Da- at the meetings. Sanja Roje and Toni of this relationship. They will keep vid Schulz, Daniel Cook, and Jack Kutchan volunteered to serve on the the executive committee updated as Blount. The calendar for newsletter committee. David also reported on these discussions progress. release was discussed at length at the the selection of Neish Young Inves- Future meeting sites and options executive committee meeting and the tigator awardees for this year (Al- were presented. They are: executive committee recommended bena T. Dinkova-Kostova, Adrian that newsletter “publication” dates D. Hegeman, Mi Kwon, and Aruna 2012 – London, Ontario (Organizing for 2012 be January 30, May 1, Sep- Kilaru). The committee will also be Chair, Mark Bernards) tember 15, and December 15. There making a prestigious Life Member was consensus that this was a good Award at the banquet, but the name 2013 – Corvallis, Oregon (Organiz- schedule and accommodated timely was not given so that the recipient ing Co-Chairs, Fred Stevens and reporting from the 50th anniversary could be surprised. Toni Kutchan) conference as well as the 2012 con- The Proceedings and Publica- ference. Celia McIntosh stated her tions Committee is chaired by Edi- 2014 – possible joint meeting, in intention to include update articles tor-in-Chief David Gang and mem- discussion, more details soon on past Neish Young Investigator bers are Mark Bernards, Laurence awardees in future newsletters. Davin, Reinhard Jetter, Susan Mc- 2015 – PSNA/Am. Soc. Pharmacog- David Gang reported for the Cormick, and Fred Stevens. David nosy joint meeting (in discussions Awards and Recognition Commit- reported on delays in publication of with Barbara Timmermann) tee. Celia McIntosh also serves on Volume 42 and stated that this vol- that committee. Thanks to confer- ume would be going to the publisher 2016 – possible North Carolina ence grants obtain by Norman Lewis by the end of January 2012. This from the U.S. Department of Energy committee is having a lunch meeting Mark Bernards made a brief pre- and by Celia McIntosh from the on December 15 to discuss volume sentation of plans for the 2012 con- U.S. National Science Foundation 43 and timeline to reach publisher ference in London, Ontario. Every- added to the PSNA Loewus Stu- for timely publication and distribu- one should save the dates of August dent Travel Awards and the PSNA tion. It will also discuss strategies 11-15, 2012! (Please see elsewhere postdoc travel awards, a record of for future volumes, rotating commit- in this newsletter for more informa- nearly 40 travel awards for under- tee membership, etc. tion). graduate students, graduate students, Norman Lewis gave a brief re-

PSNA News Page 5 January 2012 As there was no further business, of Lecturer and Research Councils National University. Her research Charles Cantrell welcomed Celia UK Academic Fellow at the Medical interests are in tree growth and de- McIntosh as the current PSNA presi- Research Institute, Univ. Dundee, velopment, with special emphasis dent and assumed the role of past- Scotland. Her work on the mecha- on molecular control of secondary president. Per the Society by-laws, nism of induction of cytoprotective cell wall biosynthesis during xylem Celia will preside over the 2011 ban- proteins (through the Keap1/Nrf2/ formation in woody plants. She ser- quet. The meeting was adjourned. ARE pathway) and the chemistry of ved as an Adjunct Research Scientist 2011 PSNA inducers has been published in many in the devision of Forest Biotechno- Neish Award winners journals, including Biochemistry, logy at Korea Forest Research Insti- PNAS, Chem. Biol., J. Biol. Chem., tute from 2009. She is a recipient of J. Med. Chem., Chem. Res. Toxicol., the Future Scientist & Best Article Cancer Prev. Res. and Methods En- Award (2007) from the Botanical zymol.. It has been highlighted in Society of Korea. commentaries and attracted more than 2000 citations; one paper was featured on the American Chemical Society Publications website as being in the top 1% of the most-cited papers during the past 10 years.

Albena Dinkova-Kostova obtained her PhD in Biochemistry in 1996 Aruna Kilaru is Assistant Professor, from Washington State University Department of Biological Sciences under the mentorship of Professor at East Tennessee State University, Norman Lewis. Her doctoral work USA. She completed her B.Sc. in Bi- was directed towards purification ology and Chemistry at Andhra Uni- and characterization of enzymes of versity, India in 1991, and her M.Sc. the phenylpropanoid pathway. Dur- in Biotechnology at Maharaja Saya- ing that time she became intrigued by jirao University, India in 1993. She the fact that plant phenylpropanoids, earned her Ph.D. in Environmental some of which (podophyllotoxin and Evolutionary Biology, from the and the semi-synthetic etoposide/ Mi Kwon, Research Professor, Col- University of Louisiana at Lafayette, tenoposide) are used in cancer che- lege of Life Science and Biotech- USA in 2005, under the guidance of motherapy; others (nordihydroguai- nology at Korea University, South Prof. Karl Hasenstein. Dr. Kilaru aretic acid) are potent antioxidants, Korea. She completed her B.S. in pursued post-doctoral studies with are also inducers of anticarcinogenic Forest Product Technology in 1991, Prof. Kent Chapman at University enzymes, as shown by Professor her M.S in wood anatomy in 1993, of North Texas (2005-09) and Prof. Paul Talalay at Johns Hopkins. She at Seoul National University, and her John Ohlrogge at Michigan State joined his laboratory where she be- Ph.D. (Plant Physiology Program) University (2009-11). Her research came interested in chemoprevention under supervision of Prof. Norman interests are in plant biochemistry by chemical and dietary induction G. Lewis at Washington State Uni- and physiology, with particular em- of cytoprotective proteins. While re- versity in 2000, and post-doctoral phasis on lipid synthesis and signal- maining part-time faculty member of studies with Prof. Nicki Engeseth at ing. Specifically, she continues to the Dept. of Pharmacology and Mo- University of Illinois Urbana-Cham- unravel the metabolic pathway of N- lecular Sciences at Johns Hopkins, paign (2001-2002), and Prof. Sung- acylethanolamines, a class of bioac- since 2007 Albena holds a position hwa Choe (2002-2006) at Seoul tive lipids, in plants. Dr. Kilaru also

PSNA News Page 6 January 2012 has ongoing research to understand ing his postdoc Adrian co-authored the regulation of triacylglycerol bio- a textbook with his graduate advi- synthesis in non-seed tissues. Her sor (Frey) titled: Enzymatic Reac- work was published in high impact tion Mechanisms (Oxford, 2007). journals including PNAS, Plant Cell, He has held his appointment at the JBC, Plant Journal, among others. University of Minnesota since 2007 As a graduate student and postdoc- studying plant metabolomics and toral fellow, Aruna received various the use of stable isotopes and mass honors and travel awards to present spectrometry for methodological in- her research. Dr. Kilaru is an active novations. Other projects include: member of the American Society of exploring the botanical origins of Plant Biologists, Sigma Xi, and As- propolis collected by honey bees, sociation for Women in Science, in examining the mechanistic enzy- addition to the Phytochemical Soci- mology of plant hormone (auxin) ety of North America. biosynthesis, measuring bioactive constituents of kava (‘awa; Piper methysticum), and prospecting for antimicrobial and antioxidant compounds in native and naturalized prairie plants to use as preservatives in cosmetics.

Adrian D. Hegeman is an Assistant Professor in the Microbial and Plant Genomics Institute at the Univer- sity of Minnesota Twin Cities with appointments in the Departments of Horticultural Science and Plant Biology. He received his B.A in Biochemistry from Oberlin College in 1992, and completed his Ph.D. in Biochemistry from the University of Wisconsin-Madison in the laboratory of Perry A. Frey in 2001 studying the structure and function of the enzyme of dTDP-glucose 4,6-de- hydratase. He then continued his post-doctoral studies at the Univer- sity of Wisconsin in the laboratory of Michael R. Sussman using mass spectrometry-based proteomics and metabolomics (2002-2007). Dur-

PSNA News Page 7 January 2012 The 50th Anniversary Meeting Organizing Committee of the Phytochemical Society of North America was held December Norman G. Lewis, Ph.D. 10 – 15, 2011 on the Kohala Coast Committee Chair of Hawai‘i’s Big Island, at the Fair- Director mont Orchid, Hawai‘i. A first-rate Institute of Biological Chemistry scientific program consisted of thir- Washington State University teen general symposia were held on John M. Pezzuto, Ph.D. the following topics Local Host Professor and Dean • 50 years of PSNA College of Pharmacy • Metabolism & Metabolomics University of Hawai’i at Hilo • Natural Products in Agriculture Charles L. Cantrell, Ph.D. • Transcriptome Profiling PSNA President • Chemoprevention National Center for Natural • Phytomedicine Products Research • Phytochemistry USDA-ARS • Biodiversity Cecilia A. Mcintosh, Ph.D. • Biosynthesis PSNA President-Elect • New Characterization Methods Professor, Biological Sciences • Natural Product Drug Discovery Dean, School of Graduate Studies • Biofuels/Bioproducts & Bioengi- East Tennessee State University neering David R. Gang, Ph.D. • Medicinal Plants PSNA Past-President • Botanicals (Dietary Supplements) Associate Professor and Fellow Institute of Biological Chemistry Washington State University

PSNA News Page 8 January 2012 Mark A. Bernards, Ph.D. PSNA Past-President Professor & Chair Department of Biology The University of Western Ontario John Thor Arnason, Ph.D. Professor of Biology Department of Biology University of Ottawa Judith Fox-Goldstein, CFEE Administrative Director University of Hawai’i at Hilo Conference Center

Scientific Committee Ikuro Abe Gynheung An Yoshinori Asakawa K. Hüsnü Can Baser Rudolf Bauer Jörg Bohlmann G. Paul Bolwell Vanderlan Da Silva Bolzani Wanchai De-Eknamkul Daneel Ferreira Mary Garson Jonathan Gershenzon De-an Guo Mahabir P. Gupta Massuo Jorge Kato Ikhlas A. Khan Toni M. Kutchan Norman G. Lewis, Scientific Committee Chair Rachel Mata Susan McCormick Cecilia A. Mcintosh Birger Lindberg Møller W. David Nes Hermann M. Niemeyer M. Soledade C. Pedras John M. Pezzuto Richard Robins Michel Rohmer Rosario Rojas Kazuki Saito Joachim Stöckigt Dieter Strack Hermann Stuppner Toshiaki Umezawa Robert Verpoorte

Photos by Lawrence Davin Norman Lewis, John Pezzuto and William Kenoi, Mayor of Hawaii PSNA News Page 9 January 2012 Dr. Eric Conn, Phytochemical Pioneer Award Honeree

PSNA News Page 10 January 2012 The Attendees of the 50th Anniversary Meeting the Phytochemical Society of North America

HRH Princess Chulabhorn Mahidol

PSNA News Page 11 January 2012 Grantsmanship Workshop

National Science Foundation Travel Award Winners: (not in order of photograph) Julie Adrian, Aruna Kilaru, Amy Keller, Li Shen, Ivette Guzman, Brittany Graf, Debora Esposito, Deborah Hayford, Jessica Citronberg, Kehau Hagi- wara, Rhodesia Celoy, Sarah Brewer, Tonibelle N. Gatbonton-Schwager, Alexander W. Chassy, Patricio Rojas-Silva, Rocky Graziose, Ryne Ramaker, Anye Wamucho

Department of Energy Travel Award Winners (Not in order of photograph) Dong Sik Yang, Vaishali Sharma, Samuel Lopez-Nieves, Trevor H. Yeats, Anna Berim, Claudia Cardenas, Hong Yang, Mahmoud Gargouri, Kim Hixson, Alan Budgeon

PSNA News Page 12 January 2012 Frank and Mary Loewus PSNA Travel Award Winners (not in order of photograph) Student Travel Awards: Chih-Chun Wen, Ryuta Inagaki, Catherine Tunbridge, Carolina Cieniak, Chieu Anh Ta, Chike Azike, Trinh-Don Nguyen, Scott C. Farrow, Teagen Quilichini, João Marcos Batista PSNA Post-doctoral Travel Awards: Dovi Kelman, Daniel Owens

Best Poster Award Winners

PSNA News Page 13 January 2012 To Our Friends in the PSNA; jay Singh, had collected something Impressionists at the San Francisco Eric Conn over $50,000 from former students Museum of Modern Art while still and colleagues to establish the E. in Australia, and we had to be there It’s been an enjoyable and busy E. Conn Young Investigator Award. at a specific time on a specific day, year for all threee of us. For example This is now an annual award that as crowds were expected. Since I we’ve just returned at 1:00 AM yes- is given to a young person for pur- don’t drive into the Bay area any terday from the big island, Hawaii, poses such as travel to the meeting more, we took Amtrak from Da- where I attended the 50th anniver- or even to use in laboratory work. I vis to Richmond, transferred to the sary of the formation of the Phyto- wanted to meet Dr. Hiroshi Maeda, subway system (BART) and got off chemical Society of North America the first recipient of the prize and just three blocks from the museum. (PSNA). I was one of the early presi- was able to do so. He received his We spent several hours there seeing dents and was invited to attend and Ph. D. at Purdue and has now been masterpieces by Cezanne, Bonnard, give a short talk on the formation appointed as an Assistant Profes- Denis, Gris, Laurencin, Picasso, Le of the society. One of my former sor at the University of Wisconsin. Corbusier, Manet, Matisse and oth- post-docs, Dr. Birger Moller, was There was a reception and a couple ers, After a bite to eat at the muse- there from Copenhagen with several of parties that we attended, and then ums café, we headed back to Davis, of his post-docs. There were a few Kevin returned to Davis, as summer getting home about 9:00 PM, people who had taken courses from is always a busy time for him. Mike With our best wishes for 2012,. me years ago when I was teaching. and I stayed through the meeting and Also, a good friend, Nick Amrhine, enjoyed having dinners with former was there from Germany. students and friends, including Steve It was very pleasant to be in Ha- Saupe and his family. waii again as I enjoyed the warm, When the meeting finished, tropical weather. Davis winters are Mike and I flew to Santa Fe for a not my favorite time of year. I really week of opera. We were met there notice the cold now, although our by our good friend Edith Lees who minimum temperatures are seldom has come over from Sydney almost below 30 degrees at night, but also annually for many years. This year don’t go much above the 70s during we saw “The Pearl Fishers”, ”La the days. Boheme”, “Faust”, “Wozzeck” and I also had a professional meeting “Griselda” After the operas finished, in Minneapolis in early August that the three of us flew back to Davis, the three of us attended, the Ameri- and did another very interesting can Society of Plant Biology. Anoth- thing. Edith had arranged for tick- er of my former post-docs, Dr. Bi- ets to a wonderful exhibit of French PSNA News Page 14 January 2012 Arthur Neish Award Winners

Richard Hemingway, Phytochemical Pioneer Award Honoree

PSNA News Page 15 January 2012 Judith Fox-Goldstein and John Pezzuto

Joaquim Marques, Alan Budgeon, Norman Lewis, Daniel Vassao, Massuo Kato, Mark Bernards, Nidia Yoshida, Laurence Davin, Hong Yang, Kim Hixson, Sarah Brewer, Claudia Cardenas, Lydia Yamaguchi, Kye-won Kim, Steven Halls and David Gang

PSNA News Page 16 January 2012 Kim Hixson, Soheil Mahmoud, Hong Yang, Lydia Yamaguchi, Massuo Kato, Norman Lewis, John Pezzuto, Jane Ward, Kye-won Kim, James McChesney, Toshiaki Umezawa, Alan Budgeon, Michael Beale, Sarah Brewer, Claudia Cardenas, Nidia Yoshida, Daniel Vassao, Norberto Peporine Lopes, Joaquim Marques, and Nicholas Smirnoff

Steven Halls, Sarah Brewer, Albena Dinkova-Kostova, Takeshi Katayama

PSNA News Page 17 January 2012 PSNA STANDING COMMITTEES FOR OPERATION

PSNA Membership and Society PSNA Future Meetings Committee Advancement Committee Norman Lewis (Chair) Chair open: [email protected] Daniel Owens (Treasurer) Thor Arneson [email protected] [email protected] Norman Lewis Mark Bernards [email protected] [email protected] Rachel Mata David Gang (Psst President) [email protected] [email protected] John Pezzuto PSNA Website Committee [email protected] Mark Berhow USDA, ARS, NCAUR PSNA Young Members Committee 1815 N. University St. Peoria, IL 61604 Phone: 309-681-6347 PSNA Guidelines and Proceedures [email protected] Committee Desmond Slade Daneel Fereira (Chair) [email protected] [email protected] Celia McIntosh PSNA Newsletter Committee [email protected] Eric Johnson (Chair, Secretary) USDA, ARS, NCAUR 1815 N. University St. Peoria, IL 61604 [email protected] Mark Berhow (Publisher) Phone: 309-681-6347 [email protected] Jack Blount [email protected] Daniel Cook [email protected] David Schulz [email protected]

PSNA News Page 18 January 2012 Phytochemical Society of North America Sociedad Fitoquímica de América del Norte Société Phytochimique de L’Amerique du Nord Member Annual Renewal Form Please fill in the following form and return to the Treasurer with your dues payment.

Please also enter your contact information for the PSNA membership at: http://psna.uhhconferencecenter.com/?page_id=878

Payments should be made by one of the following: check drawn on a US checking account, US travelers check, or US money order, International Money Order, Credit Card on the PSNA Website or Paypal payment to [email protected] Please make check or money order payable to the Phytochemical Society of North America.

Credit Card Payment: Paying membership dues online via credit card has now been established. Please select the link from the PSNA homepage to pay by credit card. A paypal account is NOT required but will expedite the process. If using a paypal account, send directly to [email protected]

Dues schedule: Emeritus member - no charge (invitation only) Regular member - $60.00 per year Student member - $30.00 per year

Return this statement along with your payment to: Daniel Owens PSNA Treasurer USDA-ARS P.O. Box 8048 University, MS 38677

Multiple Member Renewals: Please use one of the payment methods above.

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Total Enclosed $_____ The PSNA homepage is now available at www.psna-online.org PSNA News Page 19 January 2012 Phytochemical Society of North America Sociedad Fitoquímica de América del Norte Société Phytochimique de L’Amerique du Nord New Member Application Form Please fill in the following application and return to the Treasurer with your dues payment. Once your application has been processed, you will receive newsletters and special mailings. You are also eligible for PSNA member discounts on the Recent Advances in Phytochemistry series (See Website).

Payments should be made by one of the following: check drawn on a US checking account, US travelers check, or US money order, International Money Order, Credit Card on the PSNA Website or Paypal payment to [email protected] . Please make check or money order payable to the Phytochemical Society of North America.

We would appreciate it if you would also enter your contact information for the PSNA membership at: http://psna.uhhconferencecenter.com/?page_id=878

Advance Payment: It is now possible to pay dues in advance. If you wish to take advantage of this feature, please indicate above the years for which you would like to pay in advance.

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The PSNA homepage is now available at www.psna-online.org PSNA News Page 20 January 2012 PSNA News Phytochemical Society of North America Sociedad Fitoquímica de América del Norte Société Phytochimique de L’Amerique du Nord Volume 50, Number 2 June 2012 From the President: June 2012 Grant Award”. We sent an email lish, however. Announcement of blast out to all current members: the inaugural award will be made at the 51st Annual meeting in London, “The Phytochemical Society of Ontario. Funds will be disbursed in North America is pleased to an- 2013. nounce the inaugural “Phytochem- This partnership with “Phytochem- istry/PSNA Young Investigator Re- istry” and Elsevier is most welcome. search Grant Award”, sponsored by PSNA members serve on the edito- We are looking forward to our next Elsevier, to be presented annually rial board of the journal, as ad hoc annual conference on August 11-15, to a dynamic young scientist within reviewers, and as authors submitting 2012 at the University of Western ten years of receiving their doctoral manuscripts for publication in this Ontario, London, ON, Canada. The degree and currently leading an in- high-impact journal. We are excited conference starts with a welcome dependent research program in the for this opportunity and for the con- reception on August 11 and I look broader areas of phytochemistry at tinued tradition of mentoring and forward to seeing everyone there! a university, or at a government- or supporting the scientific and career More detailed information can be not-for-profit research institute. Re- development of new scientists in the found in the newsletter and on the search award amount is $10,000 US. field. conference website http://www.uwo. Applicants must be a current PSNA See you in London! ca/biology/PSNA_2012/. Registra- member to be eligible. Applications Celia tion is still open! should include a cover letter, CV, Cecilia McIntosh, President four-page research plan, budget, We are extremely pleased to an- one-page budget justification, and nounce a new research grant pro- three letters of recommendation. gram open to PSNA members. At Submit electronic applications to th our 50 Anniversary conference, Cecilia McIntosh, President of the Vice President Toni Kutchan and I PSNA ([email protected]) by July had some very fruitful discussions 1, 2012.” with Tom Clarke from Elsevier. We continued those conversations Note that this is open to any PSNA with Joy Ideler from Elsevier and member that meets the criteria; the result is the “Phytochemistry/ country of residence is not a fac- PSNA Young Investigator Research tor. Applications must be in Eng-

In this issue: Dr. Richard Hemmingway, 2012 PSNA Phytochemical Pioneer, PSNA Pioneer Awardee Helen Stafford’s gift to Reed College

The web PDF version can be downloaded from the website: www.psna-online.org.

PSNA News Page 1 June 2012 PSNA News The PSNA EXECUTIVES January 2012 Phytochemical President Cecilia A. McIntosh, Ph.D. Society of Dean, School of Graduate Studies Professor, Biological Sciences North America East Tennessee State University Burgin Dossett Hall Room 309K The Phytochemical Society of North PO Box 70720 America (PSNA) is a nonprofit Johnson City, TN 37614-0720 scientific organization whose 423-439-4221 (telephone) membership is open to anyone with CONTENTS [email protected] Presidents Letter … 1 an interest in phytochemistry and the President Elect Toni Kutchan, Ph.D. 2012 PSNA Meeting … 3 role of plant substances in related fields. Annual membership dues are Member, Oliver M. Langenberg Dr. Richard Hemingway … 5 U.S. $60 for regular members and Distinguished Investigator, Helen Stafford $30 for student members. Annual VP for Research, & Reed College … 8 meetings featuring symposium Danforth Center 975 N. Warson Rd. topics of current interest and St. Louis, MO 63132 contributed papers by conference 314-587-1473 WWW.PSNA-ONLINE.ORG participants are held throughout the [email protected] United States, Canada, and Mexico. Past President PSNA meetings provide participants Charles Cantrell, Ph.D. with exposure to the cutting-edge USDA-ARS, Natural Products research of prominent international Utilization Res. Unit scientists, but are still small P.O. Box 8048 enough to offer informality and University, MS 38677 USA intimacy that are conducive to the 662-915-5898 (phone) [email protected] exchange of ideas. This newsletter is Secretary circulated to members to keep them Eric Johnson, Ph.D. informed of upcoming meetings and Crop Bioprotection Research developments within the society, and USDA-ARS-NCAUR to provide a forum for the exchange 1815 N. Univeristy St. of information and ideas. If you Peoria, IL 61604 USA would like additional information 309-681-6177 (phone) about the PSNA, or if you have [email protected] material that you would like included Treasurer in the newsletter, please contact the Daniel Owens, Ph.D. Natural Products Utilization Research PSNA Secretary or visit our website USDA-ARS at www.psna-online.org. Annual P.O. Box 8048 dues and changes of address should University, MS 38677 ADVISORY COUNCIL be sent to the PSNA Treasurer. Also 662-915-1039 (phone) check the PSNA website for regular [email protected] Daniel Owens (2 year term) updates. Editor-in-Chief, RAP [email protected] The PSNA is an all volunteer David R. Gang, Ph.D. organization which depends on its Associate Professor and Fellow Fred Stevens (2 year term) Institute of Biological Chemistry [email protected] membership to run the organization. We appreciate the time and effort Washington State University P.O. Box 646340 Mark Bernards (3 year term) these volunteers are putting in Pullman, WA 99164-6340 [email protected] to keep the organization up and 509-335-0586 (phone) running. As a member, please [email protected] Norman Lewis (3 Year Term) consider volunteering to serve on [email protected] one of these committees. The PSNA can always use more help! PSNA News Page 2 June 2012 PSNA 2012 is Only Two Months Cook, USDA ARS Poisonous Plant neering, Western University, Lon- Away! Research Laboratory, Logan, UT don, ON, Dr. Emma R. Master, De- Planning for PSNA 2012, (August partment of Chemical Engineering 11-15, 2012, in London Ontario, Symposium I Biosynthesis & Metab- and Applied Chemistry, University Canada) is well under way. We are olism, featuring Dr. Argelia Lorence, of Toronto, Toronto, ON, Dr. Art J. now within two months of the start, Metabolic Engineering, Arkansas Ragauskas, School of Chemistry and but there is still time to register and State University, and Dr. Kevin Biochemistry, Institute of Paper Sci- submit an abstract. The deadline for Walker, Chemistry/Biochemistry & ence and Technology at Georgia In- early bird registration and abstract Molecular Biology, Michigan State stitute of Technology, Atlanta, GA, submission is June 30. Abstracts University. and Tom Rosser, Assistant Deputy received by the end of June will be Minister, Canadian Forest Centre, published in the journal Pharmaceu- Symposium II Genomics & Bioin- Ministry of Natural Resources, Gov- tical Biology. formatics, featuring Dr. Anne Os- ernment of Canada, Ottawa, ON. Please visit www.uwo.ca/biology/ bourn, John Innes Centre, Norwich PSNA_2012 for full conference reg- Research Park, UK and Dr. Daniel Symposium V Phytochemicals in the istration and abstract submission in- Kliebenstein, Department of Plant Interaction Between Plants and their formation. Sciences, University of California Environment, featuring Dr. Doro- In addition to two Arthur C. Niesh Davis thea Tholl, Department of Biologi- Young Investigators, we have ar- cal Sciences, Virginia Polytechnic ranged fourteen invited speakers Symposium III Botanicals & Me- Institute and Dr. Jim Tokuhisa, De- in five separate symposia. There is dicinals, featuring Dr. Ilya Raskin, partment of Horticulture, Virginia space in the program for an addi- Global Institute for BioExploration, Polytechnic Institute. tional 32 oral presentations (to be Rutgers University and Paula selected from submitted abstract), Brown, BC Institute of Technology, We hope to see you in London (On- as well as unlimited space for poster Vancouver, BC. tario) in August! presentations. Symposia will cover five broad areas of interest to phy- Symposium IV Bioproducts From Conference sponsors include Natu- tochemists, and include a great cast Canadian Forests; Production of ral Resources Canada, the American of invited speakers. Symposia and Valued Attributes, featuring Dr. John Chemical Society (Journal of Natu- confirmed speakers include: Thor Arnason, Department of Biol- ral Products), Western University ogy University of Ottawa, Ottawa, and the Faculty of Science (Western Neish Investigators: Dr. Mark Su- ON, Dr. Franco Berruti, Department University). Free advertising has mara, Agriculture and Agri-Food of Chemical and Biochemical Engi- been provided, in part, by Elsevier Canada, London ON, and Dr. Daniel (Phytochemistry). PSNA News Page 3 June 2012 area. My dad did everything pos- erate steam and electricity. Richard W. sible to make up for the years of ab- Hemingway sence during WWII. He included me When I was 71, Helen and I went up in a wide range of hunting (mostly the same road we built 50 years ago An Autobiography for quail, ducks, and pheasants) and when I worked for Brooks Scanlon. Pioneer Scientist Awardee at the fishing trips. We went to the Mink 50th PSNA meeting, 12/2011. Lake Basin on the Cascade Summit for trout and other times to British This biographical note is offered as Columbia for salmon. a summary of my memories of the many people and places that were important in trying to do some science over a span of more than 50 years. I hope this biography will give the vibrant group of young sci- Mt. Washington viewed from Cache entists that attended the 50th Annual Mt. PSNA Meeting in Hawaii a stimu- lus to keep working to advance our A view of the Cascades from High- That reminded me of landing on the way 20 just west of Bend knowledge of plants. Above all, I back of a sleeping black bear while hope that they can make journeys in setting cut and fill stakes to make their life in science similar to those I the road. The summer between have enjoyed in so many interesting my junior and senior years of high places with so many good friends. school, my parents were building a new home in Bend and I made my first business: Hem’s Dirt Co. I also met Helen Dyer, the girl that became my partner and wife for more than Our 50+ yr old cabin used for deer hunting. 50 years. She liked dancing at real western “honky tonks” but also was very serious in making me pay attention to learning something useful. I studied Forestry at Oregon State in A view of Crater Lake National Park Corvallis starting in the fall of 1957. about 2 hours drive south of Bend. A year later Helen went to U. of Or- egon in Eugene to study English. I grew up in Bend, Oregon, the son of Dr. Max and Helen Hemingway. Thank goodness it was only about In my formative years during WW2, 60 miles between Corvallis and Eu- Dr. Max was in France and later in The headwaters of the Metolius River. gene. the South Pacific managing hospi- tals. My mom tried to manage my As a teenager, I was blessed to have a sister Kris and me over those war series of summer jobs, mostly work- years. ing for Hans C. Milius who was in charge of Forestry for Brooks Scan- With beautiful views of the Cascades lon, Inc. He gave me experiences in and a short drive to the High Desert, marking timber to cut from company Bend was a wonderful place to grow lands and cruising marked timber of- up. I love the mountains and desert fered for sale on Forest Service land. equally. Even as a young boy, my I also had a summer or two helping questions about what made different with forest road building, pulling up plants different worked on my mind. rail tracks when they changed to all Goodness knows, we had a vast ar- trucking, and even chipping scale Richard and Helen together at a ray of different plants in the Bend party in Eugene before we married. off the inside of boilers used to gen-

PSNA News Page 4 June 2012 When we married, we had nearly two more years of undergrad school to do. We first rented a tiny house near campus and then moved to a real log cabin out on Soap Creek adjacent to OSU’s McDonald For- est which Dale’s dad gave us rent free. He also gave us a pickup if we My family getting ready to go to would look after his property. That Australia. was an ideal life. I could catch a few trout for dinner most evenings and The research environment at the For- made a 4.0 in the most challenging Claire Allison est Products Division of CSIRO was set of classes I ever had. Helen and I just wonderful in the first few years. were in heaven. Helen pushed me to I got my MSc, and started work on a I stayed on for what ended up as five go to graduate school. We decided to PhD under Dr. Everett Ellis. About years. Sadly, in my fourth year, the go to U of Michigan in the fall. She a year after that, the University an- Forest Products Division was closed was going to have our first daughter nounced that our department would with about half of the people includ- Margaret in the summer. be closed and all the Profs in that ing Dr. Hillis’ people going to Build- Dept. started looking for new jobs. ing Research and the pulp and paper Dr. Ellis went to Oregon State Uni- people in Dr. Higgins’ group to the versity and, after much debate, I de- Chemistry. Division. Looking back cided to stay at Ann Arbor and work at my 50 years of life in research, the under Dr. Allan Mara. This gave me years I enjoyed in Melbourne at the the opportunity to change my the- CSIRO were truly the very best. We sis topic to an analysis of the ther- worked and played hard. I learned so mal instability of fats relative to the much from my colleagues. surface wettability of yellow birch wood, a topic that really excited me. George Davies was a great friend. We enjoyed many a counter lunch Margaret Irene The last three years at Ann Arbor and horse race together, including were not fun but we bulled through the Melbourne Cup and even better We drove from Bend to Ann Arbor, it. I ended up being the last gradu- country races such as Murtoa and Michigan with our one month old ate student in residence in our de- Great Western where George was ei- baby, Maggi. I booked my classes partment. All faculty was racing to ther a handicapper or an announcer. and we got student housing to start a find new jobs. Both Walt and Andy, I think he ended up a handicapper new life. Helen got a job working for my fellow PhD candidates, were de- for the Victoria Racing Commission, the geology department. layed for years before they finally a very high honor. got their PhDs. We also became good friends with While doing my thesis research, I the families of Dr. Louis Shain found a new book “Wood Extrac- (from Pennsylvania) and Dr. Gra- tives” edited by Dr. W.E. (Ted) Hill- ham McKay (from Scotland). A part is at the Forest Products Division of of our friendship came from our CSIRO in Melbourne Australia. A strong interest in fishing for trout fellow in our married student hous- and camping in the bush. To our ing unit encouraged me to write to surprise, there was very good trout Dr. Hillis inquiring about the pos- fishing at Lake Eildon in Victoria sibility of a post-doc with him. Dr. and especially at Lake Eucumbene, School of Natural Resources, U of Hillis suggested I come for two a longer drive to the Snowy Moun- Michigan. years, I passed my final defense, and tains. Surprisingly few Australians we were on our way to Melbourne had interest in trout fishing. At the end of our second year at Ann following Christmas with our family Arbor, Claire was born. Our daugh- in Bend. ters added much to our lives, still do. PSNA News Page 5 June 2012 at the Southern Research Station in retired manager of the Weyerhauser Pineville, Louisiana. Dr. Koch was, Co. chemistry group. We had a won- I think, shocked when I told him that derful relationship after he retired. my main interest was to find a way to build a research initiative that I could call my own. I started with a completely empty lab space with no equipment. I now know how much Peter Koch changed my life. He was Lake Eucumbene was great trout fishing. always in a hurry to find success but he had great patience with me. We loaded up our little Morris 1100 with all our camping gear on My good friend and partner in sci- top and went to Surfers Paradise in ence, Roland Kreibich. Queensland. There we had to sur- vive a bad typhoon – called a hur- Another good partner in my science ricane in Louisiana. was Fred Tobiason at Pacific Luther- an University in Tacoma, WA.

Peter Koch Southern Research Sta- tion. Pineville.

I still remember the surprised look on Jack Rowe’s face when I excit- edly showed him the two Buchi ro- tary evaporators, a fume cupboard, Our camp at Surfers Paradise and benches that I had installed in Fred and I enjoyed work together on my lab space when he visited from many projects and are really good One of our most favorite places was the Forest Products Lab at Madison, friends. an old aboriginal campground called Wisconsin. I will always remember Mootwin- gee out in the desert by the warm welcome that Jack gave to Going to Louisiana let me live in a Broken Hill. The cave paintings and me as I started to build my research rural environment with lots of forest rock engravings were beautiful. program. and lakes. I tried to be a bird (quail) hunter. All the good bird dogs I ever owned, and there were many, came to me through my friend Lary Ro- ton. My favorite dog is still Rusty, a Brittany who was really smart. I was lucky to have several nice English Setters including Graham shown below with Rusty as well as two really outstanding Pointers. I loved the An aboriginal cave painting. discipline involved in quail hunting At Jack Rowe’s home with me, in Louisiana. We did get some science done too. George Barton, Olaf Theander and Even today after nearly 40 years we Herb Hergert. still have good contact with Adrian Wallis and Andrew Rozsa. It was re- I got to develop a program focused ally difficult to find a job back in the on condensed tannins (proanthocy- US. I finally was accepted for two anidins) which was centered on part- interviews back in the USA. I ac- nerships with many scientists around cepted a job with the USDA Forest Rusty found a bird and is teaching the world. A important partner was Graham the setter to hold a bird on Service working for Dr. Peter Koch Dr. Roland E. Kreibich who was the point. PSNA News Page 6 June 2012 I was also blessed to find a good iting scientist from Bourdeaux, for partner Tee Clifford who loved bird all her help. hunting and we shared many years together hunting quail. Tee was mainly true to duck and goose hunting. Poppa Clifford (Tee’s dad) had a wonderful blind at Fenton, Loui- siana. We enjoyed many years of hunting ducks and geese together. I Yeap Foo, a good partner from New had found heaven in my recreation Zealand. as well as at work. I was granted another year to work as a visiting scientist at the Univer- 3rd Tannin Conference Organizers sity of the Free State, Bloemfontien South Africa.to continue work with My plan was to keep going for five Jannie Steynberg for a year as a vis- more years when we would focus on iting scientist. The students and staff what we might do to improve human working under Prof. Daneel Ferriera health. I was intent on work related were extremely patient to converse to the prospect that plant polyphe- in English rather that their usual Af- nols were important to health. That Poppa Clifford with his retriever rikaans. I hope I make a number of did not match well with the Southern Queenie and me. good friends. It was my second time Station’s research objectives. It was in Africa and I came at the time of time for me to retire from the For- I thank Peter Koch for his patience in transition to Nelson Madela and the est Service after 30 years of service. allowing me to spend a year working ANC. at the Chemistry Division of DSIR in Petone, New Zealand with Lau- rence Porter and Yeap Foo. I also spent some time working with Mike Henan an accomplished tramper getting me ready to take Helen on the Milford Track Freedom Walk. Yeap, Laurence, and I also were successful in proving the structure of three tri- Dr. Wayne McGraw and I started our meric procyanidins and solved a big A young Kudu bull surprising out in small business Plant Polyphenols problem in measuring the molecular the open at Kruger Park. LLC. This worked out well because weight profiles of various tannin ex- we could rent lab space from Louisi- tracts. I asked to step down as Project ana College and gain access to the Leader after 15 years of manage- best of their students. After about 10 years on the bench ment of our unit to be in a job as a and the retirement of Peter Koch, senior scientist with only lab work to I was surprised to be awarded the I became the Project Leader of our do. I was able to keep that position 4th Tannin Con- ference Award at group in Pineville. I tried to make a for another 5 years. Tim Rials took the meeting in Philadelphia where difference to the successful manage- over the Project Leader position and Helen broke her foot. ment of Peter Koch. I pushed hard he had us going to a strong position. to get each scientist performing as a project manager and reaching for After a lot of commotion involving the best science. I think I made my formation of a non-profit company, goals. I continued that project man- I finally was able to organize the 3rd agement work for nearly 15 years. Tannin Conference in Bend with Our unit was highly rated and all sci- Georg Gross and Takashi Yoshida. entists in the unit obtained funding This became my most satisfying from the USDA competitive grants. project. I thank Bennie Berke, a vis- PSNA News Page 7 June 2012 Bio Prof Bequeaths Fortune to Reed

By Randall Barton on February 10, 2012 10:39 AM

Receiving the Pioneer Scientist 4th Tannin Conference Award Reed Magazine Sallyportal Award. presented by Georg Gross, Herbert Reprinted with permission Kolodziej Takashi Yoshida, Daneel Feirera, and Rebecca Robbins. I am still working on my recovery When President Colin Diver an- from heart by-pass surgery about nounced last week that Reed’s Cen- Your PSNA Pioneer Scientist Award seven years ago. I ride my station- tennial Campaign had passed the was a great honor for me. I thank ary bike usually 50 miles a week and $185 million mark, he also revealed you for that. I can accept that honor I am slowly getting better. We have that the late Helen Stafford [biology so long as we all recognize the hard a wonderful life in the home we built 1954-87] had bequeathed an aston- work of my many partners, most 16 years ago out on 9 acres of forest ishing $8 million to Reed in her will. importantly Helen Hemingway who land with a lot of waterfront on Kin- The bulk of the gift will provide fi- has been my best partner for more caid Lake. If you are brave, Helen nancial aid to students otherwise un- than 50 years. will take you in her Kayak and you able to attend Reed, and $1 million might find a nice alligator. will support the biology department. Our cypress house that overlooks When news of Prof. Stafford’s gift reached her niece Anne Scarff in Amherst, Massachusetts, she was gobsmacked.

“We received a magnanimously generous gift from your aunt this week,” Mesa Verde is beautiful. we told her. Kincaid Lake. I close this note with my memory of “Oh, no kidding,” she said. “What In our retirement, we have been the many young scientists who at- was that?” making a lot of road trips especially tended the 50th Annual PSNA Meet- to the SouthWest US National Parks ing. Certainly, our science will grow. “Her estate has provided a gift to which we both love. Helen does Just look at the young scientists who Reed in excess of $8 million.” the driving and I usually enjoy the were honored at this meeting as scenery unless we get too high in the highlighted in the last PSNA News- “I’m sorry. I’m confused. Whose es- mountain roads. Ever since Mike letter. Do something fun every day. tate?” Henan took me on a mountain tramp in New Zealand where we had to [email protected] “Helen’s.” crawl over about 200 feet on a very narrow ridge with the snow blow- “Helen Stafford’s??!!! Eight mil- ing up to us from 1,000 feet below, lion? Wow! ... I’m flabbergasted. I have a serious fear of heights. The I knew that Reed would inherit sights one can see in these parks what she had. That was always made me overcome that fear. understood. But I had no idea.”

Born in 1922 to a wealthy Philadel- phia mill owner and his wife, Helen was raised in a big house with ser- vants. But when the stock market

PSNA News Page 8 June 2012 “I learned more from her patient and enlightened teaching that year than I did in class,” he said. “Helen was a quiet but inspiring person and a very fine teacher. She was an incredible woman who opened many doors, both to her students and to her gen- der.”

It was while she was teaching at the University of Chicago that she came to the attention of Reed’s biology faculty, and in particular Lewis Kleinholz [1946-1980] who recognized that the department would benefit from her exemplary teaching and research experience as well as her reputation for clear, thoughtful, innovative work.

In 1954, Helen accepted a position as Reed’s sole biology professor specializing in botany and the only female faculty member in the sciences. She and her colleagues laid the groundwork for became one of the top undergraduate biology pro- grams in the U.S.

“Helen was very active in what we were trying to accomplish, which crashed in 1929, Milton Stafford Dr. Robert McNair Scott ‘61 met was to change the whole department lost his fortune and Helen attended Helen when she was studying with and its approach to teaching,” says Wellesley on scholarship, working David Goddard at the University of Laurens Ruben [biology 1955-92]. her way through college. Pennsylvania. She had overcome “Most of our students were going prejudice to become the first woman on to graduate work and the pro- Her distinguished career began to teach male botany students at the gram we were offering didn’t create when Helen studied botany with ge- university and earned a PhD in 1951 enough depth and or take sufficient neticist Harriett Creighton at Welles- for her discoveries about plant en- advantage of scientific inquiry. We ley. She worked as a research assis- zymes. tried to take the best things of a grad- tant at Cornell, then took a research uate program and meld them with position with Richard Goodwin at “When I was considering Reed,” the best things of an undergraduate Connecticut College for Women. Robert remembers, “my mother said program.” Goodwin persuaded the college to that David considered Helen Staf- create a master’s degree for Helen’s ford one of his finest students. That Anne Wood Squier ‘60 taught labs groundbreaking thesis about the de- was one of the things that drew me for the biology department and velopment of anatomical structures to Reed.” worked for Helen one summer. and the effect of light in timothy grass seedlings. The thesis was pub- During his sophomore year, Robert “Nothing got in the way of the ab- lished in the American Journal of worked for Helen as a teaching lab solute precision of her experimental Botany, the first of her more than 70 assistant. methods and she had a passion for publications. new knowledge,” Anne says. “She found her niche at Reed where she PSNA News Page 9 June 2012 could teach bright students, and get person can make a difference.” Some years after retiring from a lot of satisfaction from pointing teaching, Helen was diagnosed with them down various pathways, and Living frugally, Helen endowed the Alzheimer’s. continue to do her work at a very $1 million Morton O. Stafford Jr. high level.” scholarship at Reed in memory of “The transition to Alzheimer’s was her brother, who was killed in World obviously very difficult, but she Anne and her husband, Professor War II. She savored her work and did it with that typical curiosity that Leslie Squier [psychology 1955-88], continued to advise thesis students she always had,” her niece, Anne, lived at the top of the canyon and of- four years after she retired from remembers. “She wanted to under- ten saw Helen walk past their drive- teaching at Reed in 1987. stand it and do what she could. I way “first with Willie, a beautiful lit- think she maintained that fine sense tle sheltie, and then after he aged out Rae Gitzendanner ‘96 looked for- of curiosity right through this transi- with each dog that succeeded him.” ward to her weekly meetings with tion of immense loss intellectually.” Helen. An automobile hit Willie, remem- Mary Potts, who was employed as bers Bert Brehm [biology 1962-93], “She spoke with such passion. Dis- Helen’s caretaker for six and a half and the dog limped around with his cussing this thesis with someone years, remembers visiting Reed’s leg in a cast. “Years later, whenev- as knowledgeable, enthusiastic and campus with Helen and her faithful er Helen chastised the dog, Willie patient as Helen was definitely an dog, Brownie. would limp in a bid for sympathy. unexpected reward. She provided an Late in his life, Willie would forget open and lively atmosphere where “Reed was her life,” says Mary, which leg had actually been injured we could test out ideas.” “she just loved it and came in five and variously, limped on different days a week with Brownie to walk legs.” Now an environmental engineer in around campus. Helen never left the Gainesville, Florida, Rae had three house without two things, her hat Helen served as a role model both areas in her thesis and while two and Brownie. So many kids on cam- for the women who took her classes were progressing, one floundered. pus knew Brownie by sight. They’d and those that followed her into the Helen felt it was important that Rae say ‘Hi, Brownie,’ and these were department as faculty. enjoy her thesis experience and sug- kids she hadn’t taught because by gested they change the thesis goals. the time I got there she hadn’t been “We all knew she was exceptional,” That which was not moving forward teaching for some time. says Pamela Ronald ‘82. “At that could be left behind and Rae would time there were still very few wom- still learn from the other areas. “We used to go to the college to col- en scientists, at least very few highly lect her biology magazines. Physi- recognized scientists. She was the “She felt the important thing was to cally the disease progresses little only woman in the department. So pursue what most interests and ex- by little. Finally she told the secre- she was definitely a pioneer and we cites you--to pursue one’s strengths tary in the department not to set the were really glad about that. We fig- rather than continue to focus on magazines aside for her anymore, ured if she could do it well then why one’s weaknesses,” Rae says. because she couldn’t comprehend couldn’t we? Having women men- what she was reading. She wanted tors meant a lot to us.” In addition to being awarded a Gug- to make sure that if they ever found genheim Fellowship at Harvard, an something that would slow down the Currently a professor of plant pathol- NSF senior postdoctoral fellowship disease that she would take it. But ogy at the University of California- at UCLA, and work on condensed that didn’t really happen.” Davis, Pamela remembers that Helen tannins at the Oregon Graduate was both very reserved and focused. Center, Helen consistently broke Helen’s legacy of scholarship, “But Helen was inspirational be- new ground with her work on aro- both as a teacher and in provid- cause she loved her work, and was matic compounds, flavonoids, pro- ing opportunities for future stu- interested in what her students were anthocyanidins, and the particular dents to become Reedies, in- thinking about. She was one of those compound plants used for defensive sures she will be remembered. professors who really gripped my purposes and to make structural ma- imagination and made me believe in terials. “Reed was everything to her,” Anne the power of the individual, that one says. “I’m so delighted that she will PSNA News Page 10 June 2012 be a part of Reed’s future; I just Following her wishes, Helen’s ashes couldn’t be happier. I almost wish were scattered on the shore of Reed it was known in her lifetime so she Lake near the blue bridge that she could enjoy some of the celebration. loved. But that wasn’t like her, she wasn’t one to do that.”

PSNA STANDING COMMITTEES FOR OPERATION PSNA Membership and Society Laurence Davin Advancement Committee [email protected] Chair open: Fred Stevens Daniel Owens (Treasurer) [email protected] [email protected] Norman Lewis [email protected] PSNA Future Meetings Committee Rachel Mata Norman Lewis (Chair) [email protected] [email protected] Thor Arneson PSNA Website Committee [email protected] Mark Berhow Mark Bernards USDA, ARS, NCAUR [email protected] 1815 N. University St. David Gang (Psst President) Peoria, IL 61604 [email protected] Phone: 309-681-6347 John Pezzuto [email protected] [email protected] Desmond Slade [email protected] PSNA Young Members Committee

PSNA Newsletter Committee Eric Johnson (Chair, Secretary) PSNA Guidelines and Proceedures USDA, ARS, NCAUR Committee 1815 N. University St. Daneel Fereira (Chair) Peoria, IL 61604 [email protected] [email protected] Celia McIntosh Mark Berhow (Publisher) [email protected] Phone: 309-681-6347 [email protected] Jack Blount [email protected] Daniel Cook [email protected] David Schulz [email protected]

PSNA Awards Committee David Gang (Chair) [email protected] Celia McIntosh [email protected] Sonja Roja [email protected] Toni Kutchan [email protected] PSNA Editorial & Proceedings Committee David Gang (Chair) [email protected] Mark Bernards [email protected] Reinhard Jetter [email protected] Susan McCormick [email protected] PSNA News Page 11 June 2012 Phytochemical Society of North America Sociedad Fitoquímica de América del Norte Société Phytochimique de L’Amerique du Nord New Member Application Form Please fill in the following application and return to the Treasurer with your dues payment. Once your application has been processed, you will receive newsletters and special mailings. You are also eligible for PSNA member discounts on the Recent Advances in Phytochemistry series (See Website).

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The PSNA homepage is now available at www.psna-online.org PSNA News Page 12 June 2012 PSNA News Phytochemical Society of North America Sociedad Fitoquímica de América del Norte Société Phytochimique de L’Amerique du Nord Volume 50, Number 3 December 2012 From the President: November 2012 Toni Kutchan State University; on Botanicals & Eggler of Villanova University for Medicinals from Dr. Ilya Raskin her work on ‘Evaluating the mecha- from Rutgers University and Dr. nism by which phytochemicals acti- Paula Brown from the BC Insti- vate cytoprotective/disease-preven- tute of Technology; on Genomics tive enzymes via Nrf2’. Dr. Eggler is & Bioinformatics from Dr. Anne Assistant Professor of Biochemistry Osbourn of the John Innes Centre within the Department of Chemistry. and Dr. Daniel Kliebenstein of the As she establishes her independent University of California Davis; for scientific research, we are pleased to Phytochemicals In the Interaction be part of her exciting career path. Between Plants and their Environ- ment, Dr. Dorothea Tholl and Dr. Also in London, we sought to revi- Jim Tokuhisa of Virginia Polytech- talize the Young Members Commit- nic Institute spoke; on the topic of tee. During one of two lunch dis- We enjoyed another successful an- Bioproducts From the Canadian cussions aimed at the many young nual meeting in August 2012 (our Forests, Dr. John Thor Arnason from members of our society who attend- 51st annual meeting as a society). University of Ottawa, Dr. Franco ed the meeting, Diana Roopchand of This year’s gathering took place on Berruti of the Western University, Rutgers University, Meg Haggitt of the lovely campus of the Univer- Dr. Emma R. Master, University of the University of Western Ontario sity of Western Ontario in London, Toronto and Dr. Tom Rosser of the and Allison Heskes of the Univer- hosted by Dr. Mark Bernards. The ADM Canadian Forest Centre made sity of Melbourne volunteered to program included oral presentations presentations. The abstract book be involved in helping with young selected from submitted abstracts, as will be made available in electronic member directed events at the PSNA well as young members invited as format online on the PSNA website 2013 meeting. Arthur C. Neish Young Investigator (www.psna-online.org/). contributors, and a poster session. As we go forward together as a so- We enjoyed invited lectures on the We were particularly pleased to have ciety in the coming year, I would diverse topics of Biosynthesis & made the inaugural presentation of like to emphasize the important role Metabolism from Dr. Argelia Lor- the Phytochemistry/PSNA Young of the young members of our small, ence of Arkansas State University Investigator Research Grant (spon- collegial group. It is of central im- sored by Elsevier) to Dr. Aimee and Dr. Kevin Walker of Michigan Continues on Page 3 ...

In this issue:

The 2012 PSNA Conference in London, Ontario

Phytochemical Pioneer Tom Maby

The web PDF version can be downloaded from the website: www.psna-online.org.

PSNA News Page 1 December 2012 PSNA News The PSNA EXECUTIVES December 2012 Phytochemical President Toni Kutchan, Ph.D. Society of Member, Oliver M. Langenberg Distinguished Investigator, North America VP for Research, Danforth Center The Phytochemical Society of North 975 N. Warson Rd. America (PSNA) is a nonprofit St. Louis, MO 63132 scientific organization whose 314-587-1473 membership is open to anyone with CONTENTS [email protected] Presidents Letter … 1 an interest in phytochemistry and the President Elect Fred Stevens, Ph.D. PSNA Buisness News … 3 role of plant substances in related Linus Pauling Institute and the PSNA 2012 Conference … 4 fields. Annual membership dues are U.S. $60 for regular members and Department of Pharmaceutical PSNA 2012 Neish Awards … 7 Sciences, PSNA Phytochemical Pioneer $30 for student members. Annual meetings featuring symposium Oregon State University, Tom Mabry … 8 307 Linus Pauling Science Center, topics of current interest and PSNA 2013 Meeting … 17 Corvallis OR, 97330 USA contributed papers by conference [email protected] WWW.PSNA-ONLINE.ORG participants are held throughout the Past President United States, Canada, and Mexico. Cecilia A. McIntosh, Ph.D. PSNA meetings provide participants Dean, School of Graduate Studies with exposure to the cutting-edge Professor, Biological Sciences research of prominent international East Tennessee State University scientists, but are still small Burgin Dossett Hall Room 309K enough to offer informality and PO Box 70720 intimacy that are conducive to the Johnson City, TN 37614-0720 423-439-4221 (telephone) exchange of ideas. This newsletter is [email protected] circulated to members to keep them Secretary informed of upcoming meetings and Eric Johnson, Ph.D. developments within the society, and Crop Bioprotection Research to provide a forum for the exchange USDA-ARS-NCAUR of information and ideas. If you 1815 N. Univeristy St. would like additional information Peoria, IL 61604 USA about the PSNA, or if you have 309-681-6177 (phone) material that you would like included [email protected] Treasurer in the newsletter, please contact the Daniel Owens, Ph.D. PSNA Secretary or visit our website Natural Products Utilization Research at www.psna-online.org. Annual USDA-ARS dues and changes of address should P.O. Box 8048 ADVISORY COUNCIL be sent to the PSNA Treasurer. Also University, MS 38677 check the PSNA website for regular 662-915-1039 (phone) Daniel Owens (2 year term) updates. [email protected] [email protected] The PSNA is an all volunteer Editor-in-Chief, RAP organization which depends on its Reinhard Jetter Fred Stevens (2 year term) Departments of Botany and Chemistry, [email protected] membership to run the organization. We appreciate the time and effort University of British Columbia, 6270 University Blvd, Vancouver BC, Mark Bernards (3 year term) these volunteers are putting in V6T 1Z4 Canada [email protected] to keep the organization up and [email protected] running. As a member, please Norman Lewis (3 Year Term) consider volunteering to serve on [email protected] one of these committees. The PSNA can always use more help! PSNA News Page 2 December 2012 President’s Message cussed the following topics. These mailing a physical copy of the news- Continued from page 1 ... were also covered in the Members letter and distribute by email and portance that we continue to provide Meeting on Tuesday. posting on the website. an environment in which young scientists can reside and excel. We are In general, the Hawaii meeting and The website is our primary means asking the Young Members Com- the London meeting have covered of communicating with our mem- mittee to communicate to us the their expenses. It is appreciated that bership and the rest of the scientific types of interactions and events that both of the organizing committees world. As such we need to try to im- they would like to see at the 2013 did an excellent job in raising funds prove its ability to capture the atten- meeting. We look to ways to keep in addition to the conference fees to tion of the major search engines by the society vibrant as we head into cover travel, awards, site fees, and adding a series of key words to the the future, both with respect to de- food for these conferences. top of the index page. Also members fining the types of research that we are encouraged to submit job post- support and to nurturing the young The PSNA got a NSF grant for the ings related to phytochemistry on investigators in the broader areas of Hawaii meeting to help cover travel the site. These will be posted for 6 phytochemistry. As with all fields of expenses for students and post docs. months unless a extension is specifi- science, phytochemistry must also The grant is pretty much a standing cally requested. evolve to meet societal needs and award, there is no deadline and the demands. I would like to include the turn around time is one month from The Executive committee had a long general membership, but in particu- application to decision to award. If discussion on the future of our year- lar the young members, in this time- we do this for next year, we should ly Recent Advances in Phytochemis- ly discussion. get this done about 8 months ahead try reviews. It is clear that the PSNA of time. needs to look at options for gener- In final comments, Dr. Fred Stevens ating an income from a published of Oregon State University in Cor- Committee membership was dis- journal, reviews, or books, as well vallis was voted President-Elect at cussed, and a few were revised, es- as making sure the reviews have a the 51st Meeting. He will assume pecially the awards committee. The significant impact factor in search position as President at the 52nd society relies on volunteer judges databases. The executive committee annual meeting that will take place to help with the conference poster is looking into collaborations with in Corvallis, Oregon from August awards. A new PSNA-Elsevier re- the Phytochemical Society of Eu- 3-7, 2013. Preparations for the 2013 search award was begun this year rope and Elsevier, plus a few other meeting under Fred’s leadership role and will be administered by this options. The goal is to try to inte- are well underway. Check out the committee. The committee will also grate our Annual PSNA meetings progress at www.psna2013.com as oversee the Phytochemical Pioneer with a publication that will generate information becomes available on- Awards and the Life Membership impact as well as income. This will line. Hope to see you in Corvallis Awards. As neither of these were be an ongoing discussion in the year next summer! awarded this year, we will be seek- ahead. ing nominations for next year. The Neish Awards are generally taken The treasurers report and updates PSNA Executive Committee care of by the meeting organizing on dues, membership were present- Meeting & Member committee, though nominations for ed. The big item to note is that the Neish awardees can be sent to the PSNA tax exempt status has lapsed Meeting Notes Awards Committee members. and needs to be reestablished. The Mark Berhow, acting Secretary Ex Comm has authorized the trea- August 11, 2012 The Publications Committee noted surer to hire a CPA to take care of Western Ontario University that physical mail has become more this problem. difficult and expensive. There is The Executive committee usually no “mass mailing” method for for- Future meetings committee will be meets during the annual conference eign mail, each has to be individu- revised on a yearly basis, and meet- to discuss topics relevant to the run- ally stamped. Also a fairly large ings need to be established as far out ning of the society. After getting an percentage is returned due to incor- as possible. the 2013 meeting will be update on this year’s meeting atten- rect addresses or “no longer at this in Corvallis, Oregon at Oregon State dance and finances, the group dis- address.” it has been decided to end University, the 2014, 2015, and

PSNA News Page 3 December 2012 2016 meetings are being discussed. 2012 Annual Meeting of the PSNA Joint meeting with the American So- ciety of Pharmacology and other or- University of Western Ontario ganizations should be carried out on London, Ontario, Canada a regular basis as long as the PSNA has significant presence in the pro- August 11 - 15 gram.

The 2012 meeting of the PSNA was hosted by the Uni- versity of Western Ontario and organized by Dr. Mark Bernards of the University’s Biology Department. Mark and the scientific committee did a great job putting together an interesting and diverse speaker program, while the University’s conference services did a superb job of taking care of the logistics, providing the food, lodging, and meeting facilities.

The campus of the University of Western Ontario is a beautiful location, with a wonderful central core of stone buildings. The talks and poster sessions were held in the The University of Western Ontario There was a great line up of invited speakers assembled for the 51st Annual Meeting of the Phytochemical Society of North America. Five symposia that largely defined the field of Phytochemistry were organized, with each one led by presentations from internation- ally recognized leaders. These included symposia on Biosynthesis & Metabolism, with featured talks on vitamin C by Argelia Lorence, and enzyme specific- ity by Kevin Walker, Genomics & Bioinformatics, with featured talks on quantitative genomics by Daniel Klibenstein and metabolic diversity by Anne Osbourn, Botanicals & Medicinals, with featured talks on phytochemical complexity by Paula Brown and metabolic Niagara Falls syndrome by Ilya Raskin, and Phytochemicals in the interaction between plansts and their environment, with featured talks on below ground terpene metabolism by Dorothea Tholl and steroidal glycoalkaloids by Jim Tokuhisa. A fifth symposium, Bioproducts From Canadian Forests: Production of Valued Attri- butes, featured talks on bioproduct research & development in Canada by Tom Rosser, medicinal plants by John Arnason, bio-oil and bio-char by Franco Berruti, enzyme conversion of forest products into high value polymers by Emma Master and conifer triterpenes by Philipp Zerbe. Each symposium was rounded out by a wide range of presentations chosen from submitted abstracts. And, there was an excellent collection of posters assembled comprehensive poster session during the week.

All Aboard! Photos by Suzanne Kohalmi and Mark Berhow PSNA News Page 4 December 2012 Thanks go out to the Organizing Committee:

Mark A. Bernards, PhD Local Host Department of Biology The University of Western Ontario Is that the United States over there? Charles L. Cantrell Cecilia McIntosh Toni M. Kutchan John T. Arnason Vincenzo De Luca Mark R. Gijzen

Visiting one of the Niagara wineries

Posters & Food! What more can you ask for?

PSNA News Page 5 December 2012 PSNA News Page 6 December 2012 PSNA News Page 7 December 2012 The Awards Banquet President Toni Kutchan and Aimee Eggler

PSNA 2012 Travel Award Winners PSNA 2012 Neish Award Winners

PSNA 2012 Best Poster Award Winners Cheers! from the Bernards Research Group

PSNA News Page 8 December 2012 The Awards Banquet included the ecology of plant toxins focusing in Ottawa, Ontario with Professor recognition of the First Annual two other genera of plants and their J. David Miller. Dr. Sumarah held PSNA-Elsevier Phytochemistry toxins: Delphinium (norditerpene al- a joint post-doctoral position with Award, Dr. Aimee Eggler of Vil- kaloids) and Lupinus (quinolizidine Carleton University and the Merck lanova University, our two Neish and piperidine alkaloids). The influ- Frosst Centre for Therapeutic Re- Award Winners, Dr. Daniel Cook of ence of environment, development, search in Montreal, Quebec. He cur- the USDA, ARS, Logan UT and Dr. and genetics on toxin concentra- rently works as a Research Scien- Mark Sumarah of Agriculture and tions, synthesis, and subsequent risk tist with Agriculture and Agri-Food Agri-Food, Canada. of poisoning are being investigated Canada in London, Ontario at the to mitigate livestock losses. Previ- Southern Crop Protection Food Re- The Best Poster Awards were given ous to his current position, Daniel search Centre. His expertise is in the to: was a post-doctoral associate at the isolation, structural elucidation and Pooja Sharma, Department of Biol- USDA ARS Natural Products Utili- analysis of small organic molecules ogy & the Biotron, The University zation Research Unit in Oxford, MS from complex biological matrices of Western Ontario: “Hairy Roots where he identified and character- using LC-MS and NMR. Dr. Suma- as a Model to Investigate the Role of ized a novel polyketide synthase that rah’s current research is focused on Suberin in the PhytoppthoraSojae- uses a fatty acyl-CoA as a substrate the use of metabolomics to study the soybean Pathosystem, to form an alkylresorcinol. Daniel mechanism of resistance to disease earned a Ph.D. from Michigan State in Canadian crops. He has authored Dimitre Ivanov Department of Biol- University in Plant Biology where or co-authored 15 publications, and ogy and the Biotron, Western Uni- he studied the process of cold accli- owns a patent. versity: Ginsenosides and the Patho- mation in Arabidopsis thaliana in the genicity of Pythium irregulare laboratory of Dr. Mike Thomashow. Daniel earned a B.S. from Utah State Neish Award Winners, 2012 University in Crop Science.

Daniel Cook, PhD Mark Sumarah, PhD USDA-ARS-NPA Poisonous Plant Southern Crop Protection Food Research, Logan UT, USA Research Centre, Agriculture and Agri-Food Canada, London, ON, Canada

Daniel Cook is a research scientist at the USDA ARS Poisonous Plant Re- search Laboratory in Logan, UT. His Mark Sumarah was born and raised primary research interest is describ- in Halifax, Nova Scotia. He received ing the relationship between swain- his undergraduate degree at Saint sonine containing plants and fungal Mary’s University in Halifax, and endophytes. Additionally he pursues then completed his MSc and PhD research describing the chemical in Chemistry at Carleton University

PSNA News Page 9 December 2012 PHYTOCHEMICAL PIONEER Tom Mabry From the cotton fields of Texas to the wonderous world of plant chemistry

Born and raised on a farm a few Just after I was notified there would acid. For these studies, I synthesized miles from Commerce, Texas, some be a one-year delay before I could many analogs of ascorbic acid and 60 miles northeast of Dallas, my enter the pilot training program, compared their vitamin C activity childhood was filled with many I visited with one of my college with their structural and enzymatic good times even when working in friends Mark Norwood who was properties. These studies suggested our cotton fields with my three sib- completing his two years in the Air an enzymatic cofactor role for ascor- lings and my parents, farmer/County Force. Mark mentioned that he had bate’s vitamin activity. For charac- Commissioner Thomas Lee Mabry been accepted for graduate study in terization of these carbohydrate-type and housewife/ grade school teacher physics at Rice University in Hous- analogs of ascorbic acid, I often con- Grace Creamer Mabry. It was on the ton. My disappointment with the verted them to derivatives that were farm where I developed a curiosity delay for pilot training turned to joy soluble in organic solvents. Thus, about the natural world, which led when I took steps necessary to leave derivatization (under very mild con- me to study biology and chemistry the Air Force and study chemistry at ditions) of various classes of water- in high school. Luckily, Commerce Rice in a Ph.D. program. Although soluble natural products for NMR had a small college, East Texas in college I had been an honor stu- and GC analyses became a power- State (now Texas A&M University- dent in chemistry, I had no knowl- ful analytical procedure I utilized Commerce), which my mother, my edge of reaction mechanisms and for many of my later phytochemical siblings and I all attended at very struggled during my first semester in investigations: for example, stud- little cost. One of my proudest mo- graduate school. Nevertheless, with ies of the beet pigment betanidin ments occurred in June, 1952 when the guidance of my outstanding su- (methylation using diazomethane), I walked across the graduation stage pervisor Prof. Martin Ettlinger, flavonoid glycosides (forming tri- to receive B.S. and M.S. degrees in methylsilyl ethers using hexameth- Chemistry and a 2nd Lt. commission I completed a dissertation on the yldisilazane/ trimethylchlorosilane), in the Air Force via an ROTC pro- mode of vitamin action of ascorbic and non-protein amino acids (to gram.

Following college and six months before reporting for active duty in the Air Force, I worked as a chemist for Chance Vought Aircraft, located near Dallas. My induction into the Air Force began in San Antonio at Lackland Air Force Base, but within two months I was assigned as a Re- search Scientist to Wright- Patterson Air Development Center, Dayton, Ohio. During my two years in the Air Force, I evaluated new equipment for aerial photography, married my high school sweetheart Myra Butler, and enjoyed private flying lessons; the latter led me to sign up for pilot training for what I envisioned would Fig. 1 Tom’s genius mentor for his Ph.D. in Organic Chemistry was Rice University Professor Martin Ettlinger, shown here with his lovely Danish be a long, exciting military career. wife Lise Bolt JI)rgensen, Professor of Botany, University of Copenhagen, where Martin spent his last years before passing away in 2007. Martin was buried in Austin next to his parents. PSNA News Page 10 December 2012 N-ethoxycarbonyl ethyl esters using ethylchloroformate/ ethanol). My friend Gene Mitch finished his Ph.D. in chemistry at Rice in 1959 and then accepted a post-doctoral position with Professor Andre Dreiding in the Organic Chemistry Institute, The University of Zürich, Switzerland. Gene encouraged me to also join Dreiding’s group. With my Ph.D. degree in Organic Chemistry freshly in hand, it was in great an- ticipation in June 1960 when Myra and I boarded the Queen Mary for our voyage from New York to Eng- land, and then by train from London to Paris to pick up a new Renault. Enroute to Zürich from Paris we Fig. 3 Tom with Professor Andre Dreiding, his post-doctorate mentor at the University of Zurich, Switzerland in 1960-61. Dreiding was not only a detoured to Strasbourg, France and visiting Professor at UT - Austin in the Spring of 1966, but was also a major there crossed the Rhein River into lecturer for the first PSNA meeting held April 1966 at UT Austin; the meet- Germany in order to visit the parents ing was organized by Tom. of Rice post-doctorate Dr. Heinz I became a “natural products chem- the big cumbersome HR-60, as well Gänshirt in the small Black For- ist.” Dreiding, a brilliant, modern or- as a pretty good interpreter of spec- est city of Lahr. When we crossed ganic chemist, suggested that I tack- tra. When I initiated my lab work the Rhein, we were less than 20 le his only natural products problem, in Zürich, there was no NMR spec- miles from the German village of namely, the elusive pigments in the trometer but within a few months Lichtenau, the home of my second red beet, compounds whose struc- Varian opened a European office in wife Helga and her mother Elisa- tures had puzzled his group and oth- Zürich with an HR-60. Soon there- beth (Omi) Humm, both of whom I ers for many, many years. In my last after, I inquired of the American would meet only a few years later. years at Rice I had learned a new (at manager Les Procter if I could use that time) technique, NMR spectros- their HR-60 in the evenings and on Thus, in the summer of 1960, Myra copy, and had become an operator weekends, and to my delight he re- and I began our year and a half so- of a Varian Associates instrument, plied “okay” and handed me keys journ in Zürich, and it was here where to the offices. Within a few months I had stacks of NMR spectra of my newly prepared methylated and acetylated derivatives of neobetani- din, compounds that were not only soluble in organic solvents but that also contained all the carbon atoms of the water- soluble betanidin, the aglycone of the main red beet pigment betanin. When my data were combined with those of Dr. Hugo Wyler, Dreiding’s outstanding assistant who had elucidated key frag- ments of the pigment, the structures of the beet pigments were readily resolved. During the next few years, we determined the biosynthesis and remarkable distribution of these un- Fig. 2 Tom and Helga, a German- trained lab assistant, a few years after their marriage April 3, 1971. usual pigments, which Dreiding and I named “betalains” in 1966. PSNA News Page 11 December 2012 Chairmanship of the Department of Pharmacognosy, University of Mis- sissippi. Of course, when Klaus and his wife Helga first arrived from Germany in 1965, little did I expect Helga to become my second wife. Helga had been trained as a Chemi- cal Technician at the Science Acad- emy in Isny (in southeastern Germa- ny) and then worked as a chemistry laboratory assistant at the University of Tübingen, as well as in German industry. With such a rigorous laboratory background, including many invaluable analytical skills, Helga easily became one of my best lab Fig. 4 Dr. Walter Renold shown here with his lovely wife Verena. Walter assistants and coedited with me and was a lab assistant in Zurich for Dreiding in 1960, when Tom recognized Jeffrey Harborne the 1975 volume Walter’s talents and sponsored him to attend a small college in Texas for a “The Flavonoids.” Since our mar- B.S. degree; then he supervised him for a Ph.D. degree in plant chemistry riage in 1971, Helga has been a ter- at UT -Austin in 1970. Walter later became a top scientist and member of rific partner not only for our home the Board of Directors for Firmenich et Cie, a firm in Geneva, Switzerland specializing in perfumes and fragrances. life but also in most of my scientific adventures in almost all countries In 1962, I joined the Department of A quote from a footnote in my 2001 in the expanded European Union, Botany at The University of Texas at career review paper in the Journal of from the Canary Islands to War- Austin to develop a program in phy- Natural Products sums up the sen- saw, from London to Athens. In tochemistry determining structures, timents I quickly felt upon starting addition, we spent almost a year in distribution, and biological roles for my new position in Austin. Once at Freiberg, Germany during my ten- flavonoids, terpenoids, and alkaloids UTAustin, I soon recognized that I ure as a Guggenheim Fellow in the as well as other smaller classes of was indeed fortunate to be one of the labs of Prof. Wolfgang Barz; here I plant secondary compounds, all for first chemists in a group of biologists learned techniques for manipulating biochemical systematics studies be- who were excited to study, under- and analyzing plant cell cultures. We ing pursued by plant physiologist stand and enjoy the world of plants also had a half-dozen enormously Ralph Alston and plant systematist around us and at the same time were stimulating stays in Heidelberg in Billie Turner. The first key analysis deeply concerned with preserving the period 1983-2001 when Prof. instrument I purchased was an NMR and protecting this green earth for Dietmar Behnke hosted me during instrument; however, initially I used future generations. Within six years my Alexander von Humboldt Se- the spectrometer in the Chemistry I was a full professor envying no nior Scientist visits. Moreover, the Department at Rice University, and one as I cherished my continually village home of Helga’s mother has recorded there many of the spectra challenging extraordinary position, served every summer since 1971 as of trimethylsilyl ethers of flavonoids which was supported by several our quiet Rhein valley retreat. Since included in my 1970 volume “The large fully equipped phytochemistry his birth in 1974, our son Patrick Systematic Identification of Flavo- laboratories (GC, UV, NMR, MS, has also spent all his vacations in noids” (with post-doctorates Ken and GC-MS instruments), all staffed Germany. Still today, a special sum- Markham and Michael Thomas). with excellent botany Ph.D. students mer pleasure for me is to bicycle By 1968 I was a full Professor and and remarkable international post- from Lichtenau to the Rhein River in the 1980s served for several years doctorates who were organic chem- where I take a ferry across to France as Chairman of Botany, and since ists and biochemists. to experience another culture, really 1999, following reorganization of another world, in the Alsatian coun- Biology at UT-Austin, I have been a I recognize Dr. Klaus Fischer as tryside. However, our greatest joy is member of the Section of Molecular one the excellent post-doctorates in to have Helga’s mother with us in Cell and Developmental Biology in my lab in the 1960s; Klaus recently Austin every year from December to the School of Biological Sciences. retired to the Dallas area from the April.

PSNA News Page 12 December 2012 In my 2001 review paper, I com- mented on only four of dozens of “Biochemical and Biosystematic “Betalamic Acid and Other Products research projects: 1) establishing Studies of Baptisia Alkaloids” of the Biotransformations of L-Dopa the structures, biosynthesis, and (Morris Cranmer, 1965) in Betalain Biogenesis” (Linda Kim- distribution of the unique betalain ler , 1972) pigments; 2) the development of a “The Ultraviolet Spectral Analy- chemicalstructural basis for a bio- sis of Coumarins” (Genie Bracken- “Biochemical Systematic Investiga- chemical systematic program; 3) ridge , tions of Western Hemisphere Spe- unraveling the mechanism of action 1968) cies of the Genus Vernonia (Com- of the antiviral proteins in Phytolac- positae) Emphasizing Flavonoid ca; and 4) showing how a non-pro- “Origin of the Texas Gulf Coast Is- Chemistry” (Zeinab Abdel-Baset , tein amino acid from Guam cycad land Populations of Ambrosia psi- 1973) seeds may be involved in causing lostachya DC.: a Biochemical and the Guam neurodisease ALS-PDC Numerical Systematic Investiga- “The Chemistry and Distribution of (amyotropic lateral sclerosis-Parkin- tion” (Janet Potter, 1970) New Germacranolide-type Sesqui- son’s dementia complex), findings terpene Lactones in the North Amer- which support the hypothesis that “The Chemistry and Infraspecific ican Taxa of the Genus Vernonia substances in our diets and in the air Variation of Sesquiterpene Lac- (Compositae)” (William Padolina , we breathe may cause major neu- tones in Ambrosia confertiflora DC. 1973) rodiseases including Parkinson’s, (Compositae): Chemosystematic Alzheimer’s, and ALS. To illustrate Study at the Populational Level” “The Distribution of Azoxyglyco- additional diversity of our program, (Walter Renold , 1970) sides, Amino Acids and Biflavo- which has resulted in >600 publica- noids in the Order Cycadales: Their tions, titles of 27 of more than 60 “Nucleic Acid Studies among Cen- Taxonomic, Phylogenetic, and Toxi- dissertations and theses supervised trospermae Species” (Christina cological Significance” (Saifu Dos- from 1965 to 2002 are presented: Chang , 1971) saji , 1974)

Fig. 5 Dr. Barbara Timmermann, one of Tom’s Fig. 6 Dr. Jonathan Gershenzon, also one of Tom’s outstanding Ph.D. students, finished her disserta- excellent Ph.D. students, finished his dissertation on tion on flavonoid chemistry in 1980. Today she is a terpenoid chemistry in 1984. Today he is one of the Distinguished Professor and Chair, Dept. of Medicinal Directors of the Max Plank Institute for Chemical Ecol- Chemistry, School of Pharmacy, University of Kansas. ogy in Jena, Germany.

PSNA News Page 13 December 2012 “The Chemistry and Distribution of “Pokeweed Antiviral Protein Inac- plus graduate students and well over Sesquiterpene Lactones and Flavo- tivitates Pokeweed Ribosomes; Im- a hundred post-doctorates, I close noids in Parthenium (Compositae): plications for the Antiviral Mecha- with one more quote from a footnote Systematic and Ecological Im Impli- nism” (Maureen Bonness ,, 1992) in my 2001 Journal of Natural Prod- cations” (Eloy Rodriguez , 1975) ucts review paper that testifies to the “Isolation and Biological Proper- enormous joy I have experienced in “Sulfated and Nonsulfated Flavo- ties of Citrus Limonoids” (George my career through them. I proudly noids from Flaveria, Sartwellia, and Mitchell-Tapping, 1992) report that my role in complex bio- Haploesthes” (Munira Al- Khubaizi logical chemistry investigations and , 1977) “Protoplasts from Phytolacca do- my stimulating interactions with decandra ” (Patricia Koch , 1993) a large number of fascinating col- “Phytochemical Investigations of leagues and special friends contin- the Genus Brickellia (Compositae) “Chemical and Enzymological In- ues still today to be a great, exhila- Emphasizing Flavonoids” (Barbara vestigations of the Phenylpropanoid rating forty-year ride! Timmermann , 1977) Pathway in Elicited Cultures of Cephalocereus senilus (“old man” Finally, although I still keep my lab “Qualitative and Quantitative Natu- cactus)” David Liu , 1994) doors open for a few dedicated and ral Products Chemistry of a Desert highly talented co-workers, I do Plant Community, Andalgala Valley, “A Study of Known Excitotoxic begin to feel increasing excitement Argentina: A Chemical-Ecological Compounds and Isolated Nonpro- as I expand my personal goals and Study” (Daniel DiFeo , 1977) tein Amino Acids from Cycads” cultivate my dreams for yet anoth- (Delia Brownson,1996) er phase of what has already been “Phytochemical Investigations of over forty “Golden Years.” I like the Genus Larrea (Zygophyllaceae) “Pigment Dichotomy and Molecular the prospect of Helga and spending Emphasizing Volatile Constituents Evolution in the Caryophyllales” ( long-postponed time with numerous and Sapogenins” (Charles Bohnst- John Clement, 1997) kindred spirits and with many fam- edt , ily members including Myra and 1977) “The Role of Root Exudates in Ar- Klaus, our first spouses, with whom buscular Mycorrhizal Initiation” ( we share many special bonds. We “Biochemical Investigations of Ma- Carol Mandelbaum, 1997) especially relish the idea of finally rine Algae of the Texas Gulf Coast impersonating grandparents for the Emphasizing Amino Acids” (Paula “Estrogenic Activity of Flavonoids adorable twins William Sumner Neuman, 1978) from Cyperus alopecuroides Rottb. Cooley (left) and Thomas Mabry (Cyperaceae)” ( Amy Bystrom, Cooley (born 05- 27-00) of Michele “The Terpenoid Chemistry of He- 2002) (daughter, far left) and Webb, and lianthus series corona-solis and its the charming Cassandra Caroline Ecological and Systematic Applica- “Chitin-Induced Biosynthesis of Mabry (born 03- 02-03) of Patrick tions” (Jonathan Gershenzon , 1984) Phytoalexin 4β-Deoxyaurone in (son) and Birgit. Lastly, I warmly Cell Suspension Cultures of “Old acknowledge the generous support “ A Systematic Study of the Genus Man” Cactus, Cephalocereus seni- of the NSF, NIH, and several private Krigia (Asteraceae Lactuceae), Em- lis” ( Isagani Padolina, 2002) foundations including especially the phasizing Chloroplast DNA and Nu- Robert A. Welch Foundation, which clear Ribosomal DNA Variations” I acknowledge two very bright stu- has funded our program for over (Ki-Joong Kim , 1989) dents, Gani Padolina (listed just 40 years. Also, I express my heart- above) and his father William Pa- felt thanks to D.J. Sibley Jr., Theo “Phytoalexin Aurone Induction in dolina (eighth from the top of the Weisser, Jimmy Gill, and Feng Gao. Cephalocereus senilis (old-man list), as they are my only parent- cactus) Liquid Suspension Culture” child graduate student combina- (Paul Paré , 1991) tion. While I cannot individually express my heartfelt gratitude to all my hardworking, technically excellent, and very productive colleagues and co-workers, including the sixty-

PSNA News Page 14 December 2012 The Plant Sciences and Life Activities of Tom J. Mabry from 2003-2012

Tom J. Mabry Professor Emeritus Molecular Cell and Developmental Biology The University of Texas at Austin

At the suggestion of Eric Johnson, PSNA Secretary, I write this short paper to update my career since 2003, when my previous article on lithe wondrous world of plant chemistry” appeared in the December Fig 1. Mabry’s last PhD student Lalita Calabria (Pinchot) with her husband, 2003 PSNA News. Gifford (Marco) Pinchot IV, a fishing industry businessman, and their two First I mention something that has children, baby Isla Reed and Rowan Marie. been significant in shaping my view of life. When I was about 12 years old my parents were given a set of encyclopedia volumes, one of which contained a chapter that excited me, and ultimately changed my inter- pretation of life, namely {(The Ori- gin of Species” by Charles Darwin. Thus, during my 40 plus years as a Professor for Biological Chemistry at The University of Texas at Austin, I taught the chemical reactions that might have led to life; in addition, I always had long discussions on how evolution has given us the diversity of life on this earth as we know it today. The next comments concern my Fig 2. Tom in his new home office with wife Helga; the top three shelves plant chemistry program in the are filled with his students dissertations and theses; the two smaller mid- 2003-2012 period. My research dle shelves house Tom’s 15 books, including If The Flavonoids”, coedited grants continued to be well funded by Tom, Jeffrey Harborne and Helga. for several postdoctorates from the more. My last Ph.D. student, Lalita first occurred in the spring of 2004 Middle East, Asian and elsewhere, Calabria (Fig 1) finished her stud- during one of my regular long walks. as well as for many undergraduate ies in the fall of 2008 and was rec- I suddenly had enormous back pain; students and the last of my graduate ognized by The University of Texas several local back surgeons identi- students. These coworkers published for her {(Outstanding Dissertation”: fied the problem as severe deterio- over 50 papers describing many new {(The Isolation and Characterization ration of my spine (scoliosis) and natural products, some with such of Triterpene Saponins from Silphi- suggested inserting a long rod next properties as being anti-tumor and um and the Chemosystematic and to the spine. My German wife Helga anti-viral; included were lipids, sa- Biological Significance of Saponins and I had already booked our an- ponins, flavonoids, terpenes, -hor in the Asteraceae”. nual trip to visit her mom, who lives mones, phenyflavanes, hydroxylac- Next I describe two very different near Baden-Baden. Once in Ger- tones, phenolics, benzoquinones and unexpected non-science events. The many one of my friends suggested I PSNA News Page 15 December 2012 see Dr. Franz Copf, a top European meals, transportation and clothing; botany books, and at least one copy back surgeon in Stuttgart and have moreover, one couple leaving for a of each of the 750 papers published him evaluate my problems. This ul- cruise vacation even handed us the in my career. timately led to my retiring from UT keys to their home, where we stayed My last comments are to express my in 2006 so I could plan for three sur- for about 10 days. We rebuilt on the thanks to our only daughter Michele, geries requiring about 3 months in same foundation with several design her husband Webb and their twin Copf’s clinic in 2008; since these changes, including a big new of- boys, William and Thomas (Fig. 3) surgeries I have not yet had back or fice for me (Fig 2). I am just now, for moving from Dallas to Austin bending problems! Spring 2012, closing my University at Helga’s suggestion. Michele, a The other unexpected event occurred office and moving important materi- high school science teacher in Dal- January 17/18, 2009; our home al into my home office where I just las, had no difficulty finding a simi- burned down as the result of an at- placed 70 plus dissertations and the- lar position in the Austin area and tic electrical short. Our neighbors ses of students I supervised, as well Webb an architect, was even luckier provided remarkable help, including as copies of my 15 plant chemistry/ as his Dallas architectural firm had an office in Austin that was in need of an architect. Their move to the Austin area was just a few months before our January 2009 house fire, and they have pitched in to help us as needed. Their living close to us makes for many wonderful regular family gatherings; this is especially important as our only son Patrick is the General Counsel for an invest- ment firm in Luxembourg and his 9 year old daughter Cassie (Fig.4) lives in Munich with her mom, Pat- rick’s ex-wife. Tom and Helga’s trip to Germany this year is booked for May 9-August 2, 2012 I now end my comments on my very Fig 3. Daughter Michele Cooley with husband Webb and their twin boys Wil- satisfying career with best wishes to liam and Thomas (they will be 12 years old April 27, 2012). all my wonderful and productive former students, colleagues and co- workers! Auf Wiedersehen! (Tom celebrated his 80th Birthday in Germany, June 6, 2012.)

Fig 4. Our son Patrick, photographed with his daughter Cassie celebrating her 9th Birthday on March 2, 2012 in Munich.

PSNA News Page 16 December 2012 PSNA STANDING COMMITTEES FOR OPERATION 52nd Annual PSNA Membership and Society PSNA Future Meetings Committee Advancement Committee Mark Bernards Meeting of the PSNA Chair open: [email protected] Daniel Owens (Treasurer) David Gang [email protected] [email protected] www.PSNA2013.com Norman Lewis Fred Stevens [email protected] [email protected] Rachel Mata Deyu Xie Join us August 2013 for the 52nd [email protected] [email protected] Annual Meeting of the Phytochemi- cal Society of North America, Au- PSNA Website Committee PSNA Young Members Committee gust 3 – 7, 2013, which will be held Mark Berhow in Corvallis, Oregon on the campus USDA, ARS, NCAUR 1815 N. University St. PSNA Guidelines and Proceedures of Oregon State University. We look Peoria, IL 61604 Committee forward to hosting you. More infor- Phone: 309-681-6347 Daneel Fereira (Chair) mation will be available on this web- [email protected] [email protected] site as it becomes available. Desmond Slade Celia McIntosh [email protected] [email protected] 2013 PSNA MEETING PSNA Newsletter Committee LaSells Stewart Center Eric Johnson (Chair, Secretary) Oregon State University USDA, ARS, NCAUR 875 SW 26th Street 1815 N. University St. Peoria, IL 61604 Corvallis, Oregon [email protected] August 3 - 7, 2013 Mark Berhow (Publisher) Phone: 309-681-6347 Registration Open Early 2013 [email protected] Jack Blount [email protected] Daniel Cook [email protected] David Schulz [email protected]

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