U . 5. DEPARTMENT OF June 15, 1965 NATIONAL INSTITUTES OF HEALTH HEALTH. EDUCATION. AND WELFARE Vol. XVII, No. 12 PUBLIC HEALTH SERVICE

Scientists Develop PSB Announces New Seminar Explores Progress, T-6,7,9 Bus Service Mouse Leukemia To NIH Reservation Trends in Research on Aging Additional public tmnsporlation to NIH is now being provided by Test Tube Study the D.C. Transit Company. The Mouse leukemia viruses can now Plant Safety Branch announced be studied in a test tub€. Devel­ that arrangements were completed oped by scientists at the National for the new service to begin this Institute of Allergy and Infectious week. Diseases, the new procedure is an Last Sunday, June 13, the local adaptation of the standard com­ T-6 bus was rerouted to include plement fixation antibody test for a stop within the NIH reservation. the study of mouse leukemia vi­ Express buses T-7 and T-9 were ruses gro-..vn in tissue culture. rerouted Monday, June 14, for The new test provides a precise, extra rush hour service. sensitive, reproducible method for Ente rs MIH First detecting laboratory-adapted as well as naturally occurring stt·ains The T-6 bus, which forme1·ly pro­ of mouse leukemia within two to ceeded from the Friendship Heights six weeks. Terminal at Wisconsin and Western Or. Ewald W . Busse, Dire ctor, Ce nter for the Study of Aging, Duke Univer• Avenues, N.W., to the Naval Medi­ sity (for right foreground ) explains o point to writers ottending the PHS lnoculotion Test Slower cal Center, will now enter the NIH Science Writer Seminar on Reseorch Progress ond Tre nds in Aging he ld at Previously, virus growth could reservation before continuing to MIH. To the left of Dr. Busse, two other seminar porticiponts are Or. Reubii, be determined only by inoculating the Naval Medical Center. Andres, Assistont Chief, MHI Gerontology Branch, and Dr. Albert I. Lansing, mice and observing them for the The bus will proceed north on Professor and Chairman, Department of Anotomy, University of Pittsburgh development of leukemia-a pro­ Rockville Pike and enter the NIH School of Medicine.-Photos by Je rry Hecht. cedure which requires three to 12 reservation at South Drive, stop at months. Center Drive east of Building 1, Investigators from seven universities and NIH discussed progress and The test is based on the observa­ and exit on Wilson Drive. It will trends in aging research v.rith 23 writers at an all-day PHS Science tion that mouse leukemia viruses then cross Rockville Pike, proceed Writer Seminar held here re_cently. have at least one major common through the Naval Medical grounds Organized by the National Institute of Child H ealth and Human De­ antigen. Virus growth was demon­ and return south on Rockville Pike velopment Public Information Of­ strated by the formation of viral to the Friendshlp Heights terminal. fice, the seminar was held at the a statistical description of our ag­ request of the President's Council ing population, emphasizing the (See MOUSE. Paoc ,1) (See BUS SERVICE. T'age I ) on Aging as a special activity dur­ increasing portion of our popula­ ing Senior Citizens Month. tion that is 65 years and older. Stars and Stripes Flies Over the Nation The seminar participants consid· Dr. Bernice L. Neugarten, Pro­ ered aging research from the socio­ fessor of Human Development at As Flag Day Marks 188th Anniversary logical and psychological to the the University of Chicago, next cellular and molecular aspects. discussed the sociology of aging. Flag Day was observed yesterday throughout the Nation, and at NIH Many factors were suggested as She said changing age patterns in the large (10 x 19 ft.) Dress Flag of the United States was flown. being important in aging, includ­ American marriages are making It was 16 years ago, on August 3, 1949, that President H arry S. Tru­ ing: Changes in connective tissue grandparenthood a phenomenon of man signed into law a bill officially that make it increasingly less elas­ middle age rather than later years. l'ecognizing June 14 a,s Flag Day. tic; death of ineplaceable cells; Dr. Ewald Busse, Director of Although not a legal holiday, this and increasing errors in cells' abili­ the Center for the Study of Aging day is observed nationally to com­ ties to reproduce new normal gen­ at Duke University Medical Cen­ memorate the adoption of a reso­ erations of cells. lution by the Continental Congress (Scc AGING SEMINAR. Paoe 5) on June 14, 1777, making the Stars Other Factors Cited and Stripes the flag of the United Also clogging of some cells with Clinical Center Blood Bank States. reticular membrane; effects of ra­ Reports Donations for May There are five flag poles on the diation; a nd improper diet in the The Clinical Center Blood NIH reservation. Old Glory is al­ young whlch hastens maturity and, Bank reports that 139 units of ways flown in front of Buildings hence, the process of aging. blood were received from NIH 1, 31 and 38. At the Clinical Cen­ The scientists pointed out that donors during the month of ter, the American flag always flies no one can be certain whether or May. In the same period CC from the right hand pole and one not aging is paced by one or a few patients received 1,370 units of three others flags may be flown processes, is simply a product of of blood. from the other pole. many independent processes, or re­ The bank also reports a new Usually, Monday through Fri­ sults from a central process. gallon donor: J ohn E. Polen day, a white flag with the PHS Dr. Leroy E . Duncan, Head of of the Shop Section, Plant En­ Old Glory and the white PHS Flag Corps Device (a winged caduceus the Section on Comparative and gineering Branch, Division of wave proudly in front of the Clinical crossed with a fouled anchor) in Human Biology in NICH D's Aging Research Services. Center,- Photo by Je rry Hecht. (See FLAG DAY, Pao• 8) Program, opened the seminar with Page 2 June 15, 1965 THE NIH RECORD Dances of 6 Nations Captivate Patients At CC' s 1st International Folk Festival By Lauren Binda ecord CC Normc,l Volunteer Patient "Fou1·teen, please---and hurry!" the spunky 8-yca1·-old in the wheel­ Published bi-weekly at Bethesda, Md., by the Public Information Section, chair exclaimed to the elevator operator in the Clinical Center. Office of Research Information, for the information of employees of the National Instit utes of Health, principal research center of the Public "Where's the fire?" a member of the older generation asked, winking Health Ser vice, U.S. Department of Health, Educa tion, and Welfare, and good-naturedly to his companions. "Don't you know? The Interna­ circulated by request to interested members of the public. The NIH Rec­ Dr. Geisser Participates ord content is reprintable without permission. Pict ures are available. tional Folk Festival in the Assem­ bly H all. We can't be late!" In First lnt'I Symposium NIH Record Office ...... Bldg. 31, Rm. 4B13. Phone: 49-62125 Enthusiasm of this nature typi­ fied the feeling at the "first, and On Multivariate Analysis Editor ...... E. Kenneth Stabler hopefully annual, International F olk Associate Editor ...... George J. Mannina Dr. Seymour Geisser, Chief of Festival for CC patients," accord­ the Biometry Section of the Epi­ Staff Correspondents ing to Arnold Sperling, Chief of demiology and Biometry Branch, Georgiana Brimijoin, NCI ; Tony Anastasi, NHI; J an Etheridge, NIAID; the CC Patient Activities Section, National Institute of Arthritis and Mary Anne Gates, NIAMD; Bob Callahan, NIDR ; Ga il Dearing, NIMH; who was M.C. for the event. Metabolic Diseases, is participating Frances Dearman, NIN DB; Elsie Fahrenthold, CC; Faye Peterson, DBS; Six countries were represented t his week in the first International Linda J acobson, NIGMS; Beverly Warran, DRFR; Dick Turlington, DRG; in the song and dance presentation Symposium on Multivariate Analy­ Bill Kleven, DRS; Frances Mills, OAM; Dan Rogers, NICHD. for the patients and their guests sis. The NIH Record reser ves the right to make corrections, changes or recently in the CC, sponsored by The symposium, which began deletions in s ubmitted copy in conformity with the policy of the pa per various clubs and organizations in yesterday and will continue through and the Department of Health, Education, and Welfare. the Washington area. June 19, is being held at the Uni­ The Scots led the way with the versity of Dayton in Ohio under U.S. Air Force Pipe Band. The 9- the sponsorship of the U.S. Air NEWS/rom CC Schedules June 24 member unit piped and drummed Force's Aerospace Research Labor­ Marine Band Concert through five selections, entering atories. and exiting through the audience. PERSONNEL The first in this season's series The J apanese daJ1cers, whose Considers Voriobles Multivariate Analysis-statisti­ ORIENTATION CHECKLIST of outdoor band concerts for Clin­ translated names mean "little cher­ New staff members and em­ ical Center patients will be pre­ ry blossoms," included 14 youJ1g cal analysis made on the basis of ployees need on-the-job orientation sented on Thursday, June 24, at girls in red and white kimonos. the simultaneous consideration of to make them feel at home and to 7:30 p.m. by the United States Their three dance numbers por­ many variables-is an important assist them in gaining personal Marine Band, on the patio adjoin­ trayed a legend or facet of J ap­ branch of statistics. satisfaction from effective work. ing the Clinical Center auditorium. anese life. It is instrumental in obtaining greater assurance of the validity During the first week, supervisors In the event of rain, the concert Swiss Dancers Perform will be held in the auditorium. of experimental results, maximum should explain the following: The Swiss took the stage next • activities and organizational N IH employees, their families precision of experimentation, and and friends are invited to attend. and held it for seven selections. efficient experimentation with re­ structure of the office; One of the highlights was a solo However, patients will have prior­ spect to economy of time and cost • duties, responsibilities, and performance of flag "twirling" with performance required; ity in seating. Arrangements were and the availability of equipment made by the OC Patient Activities the red and white Swiss flag. and personnel. • how and where to get supplies, T he Golden Greeks, eight accom­ Section through the courtesy of the Dr. Geisser will present a paper, location of cafeterias and other plished teen-age girls, presented facilities; U.S. M~rine Band. "Predictive Discrimination," which several dance selections. Later, concerns classification schemes for Safety Rules Important June 19-20 Showings they volunteered to teach their rationally assigning individuals or • safety rules, how to report circle dance to those interested. objects to categories based on one accidents and where to obtain Conclude Film Series Fifth we1,e the Spanish with the or more observational chai·acteris­ Fit·st Aid; torrid Flamenco dance. These four tics. • hours of work, leave policies A group of old-time comedies and dancers, who performed sepa­ and practices; historical short subjects will be rately and as a group, were accom­ • developmental opportunities. presented by the NIH Recreation panied by lively guitar music. Supervisors should also introduce and Welfare Association as the The Germans concluded the pro­ new employees to co-workers and final program of its silent film gram with rollicking Bavarian others with whom they wilI have series next Saturday and Sunday, dances. Four couples kept a lively contact, with an explanation of the June 19 and 20. pace, and the men especially de­ supervisory chain. The films to be shown are " P ut­ lighted the spectators with their Additional information pertinent ting t he Pants on Phmp," with nimble clapping dance. to a particular office or laboratory Laurel and Hardy; a chapter from After the door pri?.e had been could be added to help new em­ an eady serial entitled "The Mys­ awarded and the Greeks completed ployees succeed in their assign­ tic Message of the Spotted Collar;" their dance instructions, everyone ments. and "The Opening of the New York felt as the little 8-year-old in the Supervisors may also call on In­ Subway." wheelchair had anticipated-"Boy, stitute and Division Personnel Offi­ Movietime is 8 p.m. in the Clini­ that was fun!" cer·s to assist in orienting new em­ cal Center auditorium. Admission is free to all. ployees. BUS SERVICE PROPOSED SALARY INCREASE lowance rates from 12 1,l! percent Or. Murray A. Diamond, Chief , Offic.e (Continued from f'a(Jo 1) The President has proposed an to five percent of basic compensa­ of Pe rsonnel, PHS, admires the me ri­ across-the-board salary increase of tion. The T-7 and T-9 buses will follow torious service medal presented to Or. three percent fot· all Federal em­ These rates are fixed by the the same route, but will be express Harold M. Janney, Training ond Man­ ployees. This proposal is now un­ Civil Service Commission bv com­ buses from 13th St. and Pennsyl­ power Resources Branch, Notional In­ der consideration by Congress and paring consumer price le~ls in vania Avenue, N.W., with regularly stitute of Mental Heath. Or. Jack a decision may be expected soon. Puerto Rico aJ1d the District of scheduled stops in the District, for Masur, Director of the Clinical Ce nte r, Columbia, and by comparing goods the convenience of employees liv­ presented the oword on June 3 for Dr. COST OF LIVING ALLOWANCE and services available mid the ing in the downtown area. Jonney's " ... development ond ex­ The 60 NIH employees in Puerto manner of living af persons em­ Schedule information may be ob­ pansion of the medico! services in the Rico have recently been affected by ployed in Puerto Rico with that of tained from the D.C. Transit Sys­ Bureau of Prisnns."-Photo by Rolph a 1·eduction in the cost-of-living al- U.S. employees living there. tem, Washington, D.C. Fernandez. THE N IH RECORD June 15, 1965 Page 3 Dr. Gilbert L. Woodside 2 Korean Orphans Find New Home With 2 States Awarded Wins University Honor Family of NIH Employee, Edwin W. Bliss Community Mental Dr. Gilbert L. Woodside, Assist­ By Mart ha Kovacic ant to the Director for Scientific Last month an NIH employee and his wife flew to Korea on an im­ Health Center Aid Program Planning and Develop­ portant mission. Their destination was the Seoul Sanitarium and Hos­ Two States-Minnesota and Mis­ ment, National Institute of Child pital Orphanage where, after two years of correspondence, they were Health and Human Development, able to complete arrangements to souri--are the fu-st to qualify for was awarded an adopt two Korean orphans. Federal grants to aid in financing honorary Doctor of construction of community mental Science d e g r e e Now Myung Kil and Yung Chin health centers under terms of the from t he Univer­ are in their new home in America l!l63 Community Mental Health with their adopted family, and are sity of Massachu­ Centers Act. Approval of the State known as David and Todde Bliss. setts on June 13. Plans for the two States was an­ Their new parents are Edwin W. nounced last week by Secretary of Dr. Woodside, Bliss, a machine operator in the P1:ovost of the Uni­ Health, Education, and Welfare Office &!rvices Branch of the Office Anthony J. Celebrezze. versity before com­ of Administrative Management, ing to NIH in 1963, With approval of the State Plans, OD, and Enoth Bliss, who works in communities in Minnesota a nd Mis­ was honored for his the library of the Technical I nfor­ Dr. Woodside significant contri­ soui-i may now submit applications mation Division of the Naval Re­ for construction pr-0jects to the butions to the development of search. Laboratory. higher education in the Common­ mental health authority in theii· wealth of Massa chusetts, and for Friends Aid Quest State. These applications will be his service to students during h is Mr. and Mrs. Bliss, who are Sev­ assigned a priority by the State agency and forwarded to the Public almost 30 years at the university. enth-day Adventists, had heard Shown an the front steps of their com­ An experienced scientist-adminis­ through. friends in the church of He-alth Service for final review and fortable home are Mr. and Mrs. Bliss approval. trator-educator, he began teaching the many Korean orphans in need and their children (from left) Todde, biology at the University of Massa­ o-f care and adoptive homes. Doris and David. $ 35 Million Appropriated chusetts in 1936. Later he was head They already had one adopted The first $35 million of the $150 of the Zoology Depa1·tinent, Dean child, Doris Raena-Marie, age 10, tion are numerous. They will be million authorized by Congress for of the Graduate School, and became whom they had adopted from a happy to provide information about construction of community mental University Provost in 1961. home in Germany seven years ago. adoption procedures to any inter­ health centers over a 3-year period They had learned of Doris through ested persons. Chairs Co llege Committee was appropriated for Fiscal Year a minister at the church, who help­ The Bliss family resides at 3600 1965 and will continue to be avail­ Dr. Woodside was also chait·man ed with the adoption procedures. 13th St., N. W., Washington, D. C. able throughout F iscal 1966. of the Four-College Committee re­ Doris, who is in the 6th grade at In t he allocmtion of funds to the sponsible for establishing a unique the George Tr uesdell School, 9th States-based on total population, cooperative Ph.D. program involv­ NICHD Aids Publication and Ingraham Streets, N. W ., is financial need and need for mental ing Amherst College, Mount Hol­ now helping her two brothers ad­ Of Anatomical Atlas health facilities-Minnesota is eli­ yoke College, Smith College and just to a new way of life. gible to receive $639,160 of the the University of Massachusetts. The two boys have been enrolled A new anatomical atlas to clar­ in Raymond School, 10th and ify the interpretation of human available $35 million, and Mis­ Di·. Woodside earned his Ph.D. souri's allocation is $760,373. Spring Road, N. W. David Myung ovarian and testicular development from Harvard University in 1936 State Plans for Community where he was an Edward Rector Kil Bliss, age 10, is in the 4th by comparison with those phases grade and Todde Yung Chin Bliss, of differentiation that are most Mental Health Centers include an Fellow and Austin Teaching F el­ inventory of existing resources, a low. age 6, is in the 1st grade. easily seen in the monkey, Macaca During the day, when Mr. and mulatta, was published recently survey of the area needs, and estab­ His research interests include the Mrs. BUss are at work, Mrs. Bliss' with support from the National lishment of priorities to meet those effect of hormones on development; sister, Vel Ellis, helps tak;i care of Institute of Child Health and Hu­ needs. embryonic mortality as influenced the children. man Development. They also take into account other by nutrition; and chemotherapy of There is no comparable accumu­ planning efforts, since mental mouse tumors. Children Adjusting Easily lation in the literature of such health centers will be designed to Mr. and Mrs. Bliss are "delight­ data on either man or mon~y. The mesh with plans for medical facili­ ed with the boys' interest and en­ presentation in the atlas of the ties, mental retardation facilities, Film on Heart Attacks joyment of school, chut·ch, picnics two species together, both male and planning in mass transportation and concerts. and in other special problems such 1 To Be Shown by EHS female, is unique. "Our great amazement is that (See CENTERS. Page 7) Phatomicragraphs Used Heart-attack--and the care nec­ the boys a1·e adjusting smoothly essary for recovery- ts the subject and that language is no barrier. Titled "Embryology of the Ovary Study Sections Complete of this month's Emplbyee Health "Every new experience," they and Testis," the atlas presents Service movie. say, "such as using a hammer, photomicrographs in chl'onological '65 Application Reviews spinning a top, wearing a new gar­ series from the first differentiation In the 22-minute film, "Reprieve," ment, even tasting new foods, fills of the gonads to the early post­ The 62 Study Sections of the Di­ former President Dwight D. Eisen­ our boys with delight." natal years. ,·isic,n of Research Grants reviewed hower and other heart patients dis­ At present David and Todde are The 90 plates of black and white 3,953 research grant applications cuss how sensible living habits and attending the Sligo Seventh-day photomicrographs are preceded by during their April-May meetings, adherence to doctor's orders have Adventist Church at Carroll and a text and accompanied by explan­ t he third and final round of review enabled them to return to active F lower Avenues, Takoma Park, atory legends. Detailed ta.hies com­ pcl'iods dur ing F iscal Year 1965. and useful living. Md., where special services are con­ plement the data in the text. During FY 1965, a total of 12,553 The Health Service movie will be ducted for its Korean membership. The investigations on which the applications were reviewed, com­ :1hown at the Clinical Center audi­ When the boys acquire more un­ book is based were supported by pa1 ed with 11,732 for FY 1964 and torium tomorrow (Wednesday), derstanding of the English lan­ grants from the Division of Re­ 11,704 for FY 1963. June 16, at 11:30 and 1 p.m.; North guage, they will join thefr sister search Grants, National Cancer In­ These figures include new appli­ Bethesda Office Center #2, Confer­ and parents in attending senrices stitute, and the National Institute cations, supplemental applications ence Room 113, Thursday, June 17 at the DuPont Park Seventh-day of General Medical Sciences. and renewal requests, and represent at 1:30 p.m.; No1-th Bethesda Office Adventist Church at 3985 Massa­ The atlas, authored by Dr. Ger­ a seven percent increase within this Center # 1, Conference Room 202, chusetts Ave., S. E. trude van Wagenen, Yale Medical 3-yea1· span. Thursday, June 17 at 2:30 p.m.; Mr. and Mrs. Bliss state that School, and Dr. Miriam Simpson, The first round of meetings for and at the Westwood Building, several denominations maintain or­ University of California at Berke­ FY 1966, which begins July 1, will Conference Room A, Friday, June phanages in Korea and that the ley, was published by Yale Univer­ open August 30 and extend into 18 at 1 and 1:45 p.m. chHdren who are eligible for adop- sity Press. early October. Page 4 June Hi, 1965 THE NIH RECORD leading Health' legislators to Speak at Annual MRA Conference Dr. Hollister Receives Reviews Collection of NLM's John Shaw Billings Centennial U.S. Blindness Data PHS Meritorious Medal Ceremonies marking the 100th anniversary of the National Library of Dr. William G. Hollister, former Medicine as a national medical resource will be held Thursday (June 17) The Fourth Annual Conference Chief of the Community Reseach with addresses by three of the Nation's leading health legislators. of the Model Reporting Area and Services Branch of the Na­ The anniversary has been named (MRA) for Blindness Statistics tional Institute of Mental Health, the John Shaw Billings Centennial was held here recently to review received the PHS Meritorious Serv­ in commemoration of Dr. Billings the year's progress in collecting ice Award June 4 who was the Library's first Direc­ complete, reliable data on blindness from Dr. Stanley tor. in the United States. Yolles, NIMH Di­ Sen. Lister Hill of Alabama, MRA is an association of States rector. Rep. John E. Fogarty of Rhode whose blindness registers have been The medal was Island, and Rep. Leo ',\I. O'Brien revised and adapted to collect com­ awarded in recog­ of New York will be the principal plete and uniform data on blind nition of his " . . . speakers at the centennial program persons. sustained superior to be presented at 2 p.m. on the The Biometrics Branch of the performance front steps of the Library. Rep. National Institute of Neurological throughout his ca­ O'Brien will give the address orig­ Diseases and Blindness provides as­ reer and his accom- inally scheduled to be delivered by sistance in preparing State regis­ Dr. Holliste r plishments in, and Rep. Oren Harris of Arkansas, who ters for MRA membership and as­ contributions to, the Mental Health will be attending a meeting in similates data from the entire area Program at the community level." Paris. The program is open to the for an overall report yearly. In January 1965 Dr. Hollister re­ public. Member States Porticipote tired from the Commissioned Corps Secretary of Health, Education, of the Public Health Service to join and Welfa1,e Anthony J. Cele­ Participants included representa­ the medical faculty of the Univer­ This portroit, pointed by Cecilio Beaux tives of the 12 States (Connecticut, brezze, Under Secretary Wilbur J. in 189S, shows Dr. Billings wcoring sity of North Carolina at Chapel Cohen, and Surgeon General Kansas, Louisiana, Massachusetts, Hill as professor of community the gown of o Doctor of Civil Low of New Hampshire, New Jersey, New Luther L. Terry of the Public Oxford. The pointing now hongs in psychiatry. He has previously H ealth Service, also will partici­ Mexico, North Carolina, Oregon, taught sociology, anthropology, and the reading room of the Nationol Rhode Island, Vermont, and Vir­ pate. Librory of Medicine. psychiatry at nursing schools, uni­ An internationally known sur­ ginia) which make up the member­ versities and medical schools in geon, sanitarian, medical bibliog- ior officials of the Federal Govern­ ship of the Model Reporting Area. Omaha, Dallas, and Atlanta. Also, five non-member States ment, and leaders in the fields of Serves As Consultont mediciQe, medical librarianship, (District of Columbia, Georgia, and medical communications have New York, South Dakota, and Prior to joining NIMH in 1956, been invited to the centennial. Utah) which plan to join; and Dr. Hollister served as Regional voluntary, private, and govern­ Mental Health Consultant for the Following the afternoon pro­ PHS, DH EW Region IV, Atlanta, gram, the public may tour the Li­ mental agencies interested in blind­ ness. Georgia. brary and view an exhibit depict­ A medical graduate of the Uni­ ing Dr. Billings' achievements In addition to progress reports versity of Nebraska in 1941, Dr. during his long and varied ca1·eer. from member and non-member States and from the Biometrics HoJJister completed his psychia tric The Library was named the residency at Bishop Clarkson Me­ Army Medical Library in 1922 and Branch, participants heard discus­ Sen. Hill Rep. Fogorty morial Hospital in Omaha. the Armed Forces Medical Library sions on the definitions of blind­ ness and the use of blindness sta­ He also holds the degree of Mas­ rapher, educator, and authority on in 1952. It became the National tistics in program planning. ter of Public Health from Johns hospital construction, Dr. Billings Library of Medicine in 1956 when The conference, sponsored by Hopkins University and is a Diplo­ was chiefly responsible for devel­ it was made part of the Public mate in Psychiatry as well as in oping the Library into the world's Health Service. NINDB, was conducted by Dr. Hy­ man Goldstein, Chief of the Insti­ Preventive Medicine in Public leading institution for the collec­ Health. tion and dissemination of biomedi­ tute's Biometrics Branch. cal knowledge. He is a Fellow of the American Psychiatric Association and the Dr. Billings was assigned to American Public Health Associa­ Wai,hington in the Office of the MOUSE (Conlnmed / rum Pane 1) tion, and is an authority on mental Surgeon General, U.S. Army, after health in education and group distinguished service dming the antigen in mouse embryo tissue processes in staff development. Civil War as a military surgeon in culture cells infected with mouse the field. He assumed charge of leukemia viruses. the Library of the Surgeon Gen­ With one exception, all the mouse Dr. Heppel Lectures on •eral's Office, forerunner of the Na­ leukemia viruses produced antigens tional Library, in 1865. Under Secretary Secretory Biochemistry at Cornell Cohen Celebre:ue which reacted positively in the Publishe s Bibliogrophic Guides complement fixation test. Dr. Leon A. Heppel of the Na­ Serving as Library Director for A symposium on Dr. Billings' life These findings open new avenues tional Institute of Arthritis and 30 years, Dr. Billings laid the will be held at 8 p.m. in the Li­ in leukemia research. It will now be Metabolic Diseases recently deliv­ foundation for modern medical Jj. brary. Symposium panelists will possible to undertake definitive ered the first annual sumner Lec­ brarianship th rough the publica­ include Dr. Jean A. Curran, P ro­ studies of the natural occurrence tureship in Biochemistry at Cornell tion of key bibliographic guides. fessor Emeritus of the History of and transmission of mouse leu­ University. He also conceived the idea of a Medicine at the State University kemia and, hopefully, other mam­ The newly established Lecture­ punch card tabulation system for of New York; Bess Furman Arm­ malian leukemia as well. ship is named in honor of the late manipulating statistics, the first strong, former Washington news­ In addition, these findings will Cornell Professor, James Batcheller step in developments which have paper-woman and author now at be used to explore possible anti­ Sumner, who shared the Nobel Prize led to the Ljbrary's present com­ work on a popular history of the genic relationships between human in chemistry in 1946 for his discov­ puter-based Medical Literature PHS; and Dr. Frank B. Rogers, and mouse leukemia. ery that enzymes can be crystal­ Analysis and Retrieval System Librarian of the Denison Memorial The new procedure was reported lized. (MEDLARS). Library at the Unjversity of Colo­ recently by Dr. Janet W. Hartley, Dr. Heppel, who is Chief of Dr. Billings was born in Indiana rado Medical Center, and former Dr. Wallace P. Rowe, Worth I. NIAMD's Laboratory of Biochem­ in 1838 and died in 1913. NLM Director. Capps, and Dr. Robert J. Huebner, istry and Metabo1ism, gave four More than 500 special guests, in­ Attendance at the symposium all of the Laboratory of Infectious lectures on his work in enzymology cluding Members of Congress, sen- will be by spe.cial invitation. Diseases, NIAID. and nucleic acid metabolism. THE NIH RECORD June 15, 1965 Page 5 AGING SEMINAR Drs. Mueller and Harvey Intelligent Human Brain Can Trick Itself (Continued f,om Pape 1) ter, in discussing the psychopath­ Named to NCI Board of Into Types of Mental Disorder Behavior ology of aging, said those who suf­ fer a decline in mental ability as Scientific Counselors they grow old tend to be of the The appointment of two new lower social and economic levels, members to the National Cancer but there is no clear explanation Institute's Board of Scientific Coun­ for this relationship. selors was announced last F riday An overall view of the physiol­ by Dr. Kenneth M. Endicott, Insti­ ogy of aging was presented by Dr. tute Director. Reubin Andres, Assistant Chief of the Gerontology Branch, National The new members are Dr. Gerald H eart Institute. C. Mueller, Professor of Oncology at the McArdle Memorial Labora­ He emphasired the difficulties in tory of the University of Wiscon­ diagnosing diabetes in the elderly sin, whose term begins July 1, and because glucose tolerance levels Dr. A. McGehee Harvey, Director vary with age, and a level that of the Johns Hopkins University may indicate diabetes in a 30-year­ Department of Medicine and Phy­ old could be an average value for sician-in-Chief of Johns Hopkins people 65 years old. Hospital, Baltimore, whose term Lifespan Discussed begins October 1. Dr. Harold We iner adjusts his e lectronic machine to trick normal subject Dr. Robert Kohn, Associat.e Pro­ The 6-member Board, established (left) into responses similar to those found in some emotional disturbances. fessor of Pathology at Western in 1957, meets pel"iodically to re­ Findings from his laboratory ore expected eventually to shed light on the basic Reserve University, in discussing view research conducted in NCI nature of mental illness. the pathology of aging, stated that laboratories and clinics, and to ad­ the human lifespan could only be vise on plans for future studies. How rational is the normal human mind? Despite keen intelligence increased by about 11 years if a Each member serves a 4-year term. and accurate information to guide it, the normal brain can trick itself cure were found for the major Dr. Mueller has been on the staff into behavior that is similar in some ways to certail1 types of mental chronic diseases. of the McArdle Memorial Labora­ disorders. This conclusion was re- Dr. Kohn said any substantial tory since 1950. His professional ported by Dr. Harold Weiner, Di­ could. increase in lifespan would be de­ activities have included member­ rector of the Human Operant Con­ In other words, despite punish­ pendent on major advances in our ship on the Drug Evaluation Panel ditioning Laboratoi-y at St. E liza­ ment, the subjects were unable to knowledge of aging which may well of the Cancer Chemotherapy Na­ beths Hospital, Washington; D. C. overcome their first expetience come with a complete understand­ tional Service Center from 1959 to For four years, Dr. Weiner has with the machine to adjust appro­ ing of arteriosclerosis. 1962, part of the time as Chairman. been conducting a ,vide variety of priately to a new situation. conditioning studies of human be­ Dr. Weiner suggested that "such Dr. Monis Rockstein, Professor Research Intere sts Cited havior in a laboratory environ­ responding in the face of punish­ of Physiology at the University of His 1·esea1·ch interests include the ment. He described his methods Miami, pointed out that much can ment maintained by an erroneous biochemistry of cancer, the mech­ and the results of one of hls studies conviction that it is required for be learned from lower animals be­ anism of action of estrogenic hor­ at a National Institute of Mental greater reward" is similar to ob­ cause their short lifespan permits mones, and the biochemistry of Health seminar at the Clinical many generations to be studied. servations that have been made by groy,1;h regulation. Dr. Mueller was Center May 10. some psychoanalysts about mental H e noted that X-irradiation not graduated from the University of Normal subjects were seated be­ disease. only hastens the process of aging Wisconsin with an M.D. degree in fore an electronic machine and in some animals, but it also may 1946 and a Ph.D. degree in bio­ told to get as high a score as pos- Goals Noted eliminate or minimize factors nor­ chemistry in 1950. sible on an add-subtract counter In conclusion Dr. Weiner said, mally responsible for aging in oth­ Dr. Harvey received his M.D. de­ by using a button. "Our goal is to uncover key facts ers, thereby increasing lifespan. about inappropriate human be­ gree from Johns Hopkins Univer­ Subjects Seek Rewords Dr. Albert Lansing, Professor sity Medical School in 1934, and havior in the laboratory which we of Anatomy at the University of first joined the faculty in 1940. His During their fii-st experience can apply to the understandjng of other professional activities have with the machine, the subjects the mentally ill. included membership on the Ad­ were required to press the button "Our loug-range mission is to de­ visory Committee of the Armed a certain number of times in order velop a basic laboratory science for Forces Institute of Pathology from to get 100-point rewards. The sub­ the assessment and treatment of 1956 to 1961. jects pressed fast to better their maladaptive behavior in normal He will complete a 4-year te1·m score. humans and in patients. We be­ on the National Advisory Cancer When the button-pressing per­ lieve that, in time, our laboratory Council in September. Dr. Harvey's formances of the subjects were findings and methods will be ap­ consistent from day to day, Dr. research interests ai-e neurophysiol­ plicable to mental disturbance as Weiner changed the reward situa­ ogy and clinical therapeutics. seen in medical practice." tion so that the subjects could Dr. Weiner recently received a score only every 10 seconds no DHEW superior serivce award in have a finite lifespan. matter how often they pressed the recognition of bis research. Dr. F. Marott Sinex, Professor button. Yet despite normal to high of Biochemistry at Boston Univer­ I.Q.s, the subjects continued to sity, predicted that the secret of press rapidly and stated "they had Dr. Yolles Presents 55 Listening ta questions from writers at to," because "speed mattered." the Scie nce Writer Seminar ore (I. to the physiological process of aging With Service Awards will be tapped eventually, but Dr. Weiner penalized them by r.): Dr. Jomes E. Birren, Aging Pro­ subtracting a point for each un­ Dr. Stanley Yolles, Director of gram Director, NlCHD, and scientific there will always be wear and tear- the human lung, for exam­ necessary press, and even told the the National Inst itute of Mental mode rator of the meeting; Dr. Donald subjects how the machine was set. Ha rting, NICHD Acting Director and ple, cannot breathe polluted air for­ Health, presented length-of-service ever. Most of the subjects, however, con­ awards to 55 staff members of the seminar chairman; a nd Warre n T. tinued to press as fast as they Roudebush, Stoff Director of the Presi­ Dr. Donald Harting, NICHD Institute on June 4. Thirty-five em­ dent's Council on Aging, o guest Acting Director, was chairman of ployees received ce1-t;ificates and speaker ot the seminar. the seminar and Dr. James Bin-en, et·ator for the meeting. Guest pins for 10 years of service and Director of NICHD's Aging Pro­ speakers were Warren T. Roude­ 19 received 20-year awards. Pittsburgh School of Medicine, gram, was scientific moderator. bush, Staff Du-ector, President's Charles Taylor, a budget analyst spoke on the cellular biology of J. Stewart Hunter, Assistant to Council on Aging; Dr. David Price, in the Office of the Director, was aging. He said that tissue culture the Surgeon General for Informa­ PHS Deputy Surgeon General; and cited for completing 30 years of studies indicat.e that fibroblasts tion, served as information mod- Dr. James Shannon, NIH Director. service with the Government. Page 6 J une 15, 1965 THE NIH RECORD Dr. Helen Dyer Retires NIAMD Scientists Elucidate, Confirm Dr. Eyestone Discusses After Noted Career As Structure of Gramicidin by Synthesis Primate Center Concept Cancer Researcher Dr. Willard H. Eyestone, Chief of the Animal Resources Branch of Dr. Helen M. Dyer of the Nutri­ the Division of Research Facilities tion and Carcinogenesis Section, 0 0 0 0 and Resources, gave the principal Laboratory of Biochemistry, Na­ 17 address at the operung of a 2-day tional Cancer Institute, retired OH symposium in London this week on May 31. recent developments in compara­ The author of more than 50 tech­ tive medicine. nical papers, Dr. Dyer devoted Dr. Eyestone, who spoke on the much of her research career to t he scientific and admfoistrative con­ biochemical examination and com­ cepts of the Regional Primate Re­ parison of normal and malignant L·Valine residue search Center Program which he tissue, seeking an observable, quali­ helped organize and now adminis­ tative difference between the two. ters, was introduced by Professor In recognition of Dr. Dyer's con­ Sir Solly Zuckerman, Secretary of tributions to research and teaching, the Zoological Society of London. Goucher College, her Alma Mater, The symposium, sponsored by the awarded her an honorary Doctor of Zoological Society of London and Science degree at its commence­ t he World Health Organization, ment exercises June 13. centered on two main topics: the Dr. Dyer came to NCI in 1942 as use of primates in medical research a Research Fellow, recruited by Dr. with special reference to cardiovas­ Carl Voegtlin, the first NCI Direc­ cular disease and oncology; and the tor. For some years she has investi­ role of viruses in the etiology of This diogrom shows the structure of gromicid in A, a commercially-used a nti­ gated the metabolism of the carci­ leukemia in man and other animals. nogen fluorenylacetamjde and many biotic against gram- negative bacte ria which has been known since 1940, but chemicaJly related compounds in whose structure hos only recently been e lucidated by NIAMD scientists. The Chairmen Named animals. unprecedented features of this structure are (1) the a lte rnating sequence of Session chairmen included Sir natura l L- and unnatural D-amino acids; (2 ) the occurre nce of o formyl Julian Huxley and Dr. William Studies Enzyme Systems group which blocks th e first om ino ocid valine; (3) the omino-ethanol group Montagna, Director of the Regional Recently she has studied a num­ which is linked to t he lost amino acid tryptophan, and (4 ) the accumulat ion Primate Research Center at the ber of enzyme systems, comparing of water-repe lle nt groups, which is probably the reason for the association of University of Oregon. their activities in liver, in minimal gramicidin A into a dime ric form shown in the diagram. Dr. Montagna's session dealt with deviation-and in multiple devia­ the subject of primates in medical tion experimental-liver cancers. In Gramicidin, a polypeptide antibiotic used topically in treatment of local infections, was first isolated in 1940. Determination of its molecu­ research: phylogeny, availability, addition to her laboratory studies, husbandry, breeding, nutrition, dis­ Dr. Dyer prepared the first com­ lar structure has since defied solution. Complete knowledge of this structure is of fundamental importance for ease hazards of different primate prehensive Index of Tumor Chemo­ species, and the suitability of each therapy, published in 1949. establishment of conelations be­ tween the sequence of the com­ species for various research proce­ Looking back, Dr. Dyer grate­ discouraging, Dr. Voegtlin advised dures. fully recalls the influence and guid­ against publioation, since lead ponent amino acids and gramicid­ in's antibiotic activity. Besides the United States and ance of Dr. Voegtlin, "a most in­ treatment of human breast oancer Great BriUtin, other countries rep­ spiring teacher for a beginner in was being used in England then. Scientists of the National Insti­ resented at the symposium were Dr. Dyer spent the years from scientific research ... a sound, ex­ tute of Arthritis and Metabolic Belgium, France, the Netherlands, acting scientist." 1928 to 1942 at George Washington Diseases now have elucidated the Russia, and S\vitzerland. Dr. Dyer began hel· research in Universit y, where she earned the structure of gramicidin A, the ma­ 1020 under his direction in the Lab­ M.S. and Ph.D. degrees in bio­ jor component, and its congeners, oratory of Chemotherapy at the chemistry. She was appointed to gramicidin B and C, and have con­ In gramicidin B, phenylalanine Hygienic Laboratory, U.S. Public the staff and attained the rank of firmed the structure of the major substitutes for tryptophan as the Health Se1·vice, studying the mech­ Assistant Professor of Biochemis­ component by total synthesis. 11th amino acid while in grami­ anism of action of arsenicals used try. Commercially available grami­ cidin C, tyrosine substitutes for in chemother-npy in spirochete in­ Early Reseorch Noted cidin was fractionated into grami­ tryptophan in the same position. fections and the potential value of cidin A, B, and C by countercur­ The chemical structu1·e of grnmi­ A highlight of this period was lead and other metals in the treat­ rent techniques and the fractions cidfo A is particularly unique. I t her synthesis in 1938 of ethionine, ment of cancer. were analyzed for their amino acid features an a lternating sequence the ethyl analog of methionine, now Because the results with metals composition. of eight L-amino acids (natural in transplanted tumors in rats were recognized as the first amino acid amino acids of which proteins are antimetabolite and used extensively Mixture of 2 Compounds built) and six unnat ural D-amino in protein studies and in its role as Gram.icidin A was found to be a acids. a liver carcinogen in rats. mixtm-e of two compounds which The latter have been encountered Among her honors are the differed from each other only in so far only i11 peptide antibiotics Goucher College Achievement and the initial formylamino acid of the and have never before been found Ser,,;ce Award for Teaching and peptide chain. They have been des­ in such an unprecedented ratio and Research, and the George Washing­ ignated as valine and isoleucine arrangement. ton University Alumni Achieve­ gramicidins from their initial am­ This unprecedented alternating ment Award for Biochemical Re­ ino acid. pattern of L- and D-amino acids, search in the Field of Cancer. T he structur,e of each of these an unusual accumulation of hydro­ I n 1962 the American Chemical two components was confirmed by phobic groups, and the complete Society presented Dr. Dyer its gold synthesis. The molecular weight of insolubility in water of gramicidin Garvan Medal and $1,000, awarded valine gramicidin A was deter­ A readily explains its resistance to annually for distinguished services mined to be 1882 by ultracentri­ attack by the conventional proteo­ to chemistry by a woman chemist. fuge studies. lytic enzymes such as pronase, Dr. Dyer is a member of Sigma Similar degradation methods chymotrypsin, and pepsin. Xi, Iota Sigma Pi and Sigma Delta were subsequently applied to the Results of these studies by Drs. Epsilon, a F ellow in the American minor components, gramicidins B R. Sarges, E . Gross, and B. Witkop Dr. Helen Dyer seated at desk in her Association for the Advancement of and C, to locate the sites of differ­ of N IAMD's Laboratory of Chem­ NCI loborotory.-Photo by Rolph Science, and a member of numer­ ence of these gramicidins from istry appeared in the Journal of Fernandez. ous other professional societies. gramicidin A. the American Chem.ical Society. THE NIH RECORD June 15, 1965 Page 7 Study Seeks Firmer Basis for Diagnosis Virginia Porter Retires Of Neurological Abnormalities in Infants From Heart Institute Results of an extensive investigation into postural reflexes promise Virginia B. Porter, Personnel Of­ important aid to the pediatric neurologist in differential diagnosis of ficer in the National Heart Insti­ motor dysfunction or deficits in infants. tute, will retire June 18 after more F indings in the National Institute of Neurological Diseases and Blind­ than 33 years of Government serv­ ness Collaborative Study showed ice. the normal sequence of evolution fants were followed periodically At a farewell party in her honor, of postural responses to be both for a 3-year period; postural re­ employees of the Heart Institute delayed and distorted in the ma­ flexes were compared with guide­ and Mrs. Porter's many other jority of infants suffering from lines established from a serial friends throughout NIH and the cerebral palsies, degenerative dis­ study made with 66 carefully se­ Public Health Se1:vice presented her ease of the central nervous system, lected normal infants. with a pair of d1amond earrings or general psychomotor retarda­ The normals, examined at 4- to and a Steuben glass figurine. tion. 6-week intervals during their first She also received a scrapbook of Also, responses to stimuli and year of life, had been thoroughly photographs of the people and other reflex activities of normal in­ docu.mented by the NINDB Collab­ events during her years at NIH orative Study as to obstetrical and Dr. J ames E. Drorbaugh, Project Di­ fants appear to occur in a wider and a book of farewell letters writ­ range than generally has been rec- neonatal normalcy. ten by her colleagues and friends, rector of the Collaborative Perinatal The range of variation in evolu­ Research Study ot Childre n's Medico! 01,,rnized. Particular attention was including Dr. James A. Shannon, glven reflexes characteristic of ear­ tion of their postural reflexes was Director of NIH, and Dr. Ralph E. Center in Boston, is shown being ex­ used as a basis for comparison with amined by one of his young patients, ly infancy, including traction re­ Knutti, NHI Director. sponse, head control, tonic neck re­ the development of the abnormal who is participating in the NIN DB infants over a 3-year period. Joins NIH in 1946 Study. The infant's mother lends o flexes, and palmar and plantar gras11. The present study reporting nu­ Mrs. Porter first joined the staff hand during the eye examinotion.­ merous and detailed observations of NIH in 1946 as a Personnel As­ Boston Advertiser Photo. It was demonstrated in addjtion that suspension in space accentu­ in both normal and abnormal in­ sistant, and later became a Person­ ates subtle alterations of tone and fants helps establish an average nel Management Specialist. She postural attitudes which may fur­ "timetable" of the responses under joined the National Heart Institute CENTERS nish early diagnostic clues. consideration and the range of as Personnel Operations Officer in (Conti,wed froJJt Pago t:) In the study, 129 abnormal in- variations, that is, the earliest or March 1961, and became Personnel as juvenile delinquency control and latest age at which a particular Officer of NHI in November 1962. alcoholism. Studies of Dream, Sleep response can be stated to be "ab­ Prior to coming to NIH, Mrs. normal." Porter was Employee Relations Of­ Dr. Stanley F. Yolles,.Director of Patterns Shedding New the National Institute of Mental Normol Responses Tobuloted ficer in the Office of the Chief of Finance of the War Department. Health, said "Both Minnesota and Light on Schizophrenia For example, while 84 percent Missouri found that they had spe­ She had served in various other po­ Investigations into sleep latency, of the normal infants acquired sitions at the War Department cific problems and needs, and their thumb-to-forefinger pincer grasp plans include specific methods by dream latency, and eye-movement since first joining the Federal serv: density during dreaming are shed­ before the age of 10 months, 16 ice in September 1930. which they can begin to meet the percent of normal infants acquired needs and solve the problems. ding new light on t he hypothesis Mrs. Porter resides at 6817 Fair­ that there occurs in schizophrenia this grasp somewhat late1·, but all fax Road, Bethesda, Md. Center at Columbia a derangement of the neurophysio­ by age 1 year. "The Missou.ri plan includes the logical mechanisms associated with Thus, failure to thu.mb-to-fore­ proposed construction of a mental dreaming. finger pincer grasp would be in the health facility in Columbia, Mo. The In a study of 18 actively schizo­ abnormal range after age 1 year. center will be linked to the Univer­ phrenic patients, National Institute Authors of the 13-page report in sity of l\'lissouri School of Medicine. of Mental Health investigators Neurology are Dr. Richmond S. In addition to offering mental found that these subjects took a Paine, Dr. T. Berry Brazelton, Des­ mond E . Donovan, Dr. James E. health services to residents of the significantly longer time to fall Drorbaugh, Dr. John P. Hubbell area, the new center will provide asleep than non-schizophrenic con­ training for mental health person­ trols. Once asleep, the onset of Jr., and Dr. E. Manning Sears. nel from adjacent communities and dreaming was at either a very The publication credits HarvarJ Medical School; Boston Lying-in will aid these commu.nities in plan­ short or a very Jong interval. Hospital; Children's Hospital Med­ ning their own centers and learn­ Two Types Occur ing how to operate them," Dr. ical Center, Boston; George Wash­ ington University School of Medi­ Yolles explained. This evidence would suggest that cine, Washington, D.C.; and Chil­ "In Minnesota, a highly organ­ two types of sleep disorders-one ized State system of mental heal th tending to accelerate and the other dren's Hospital of the District of Colu.mbia. The work was supported clinics already exists," Dr. Yolles to retard the onset of dreaming­ in part by NINDB's Collaborative continued. "Through the Federal occur in schizophrenia. Dr. Rolph E. Knutti, NH! Director, Perinatal Research Project. construction grant program, Min­ Duration of illness did not affect hos words of praise for Virginio 8 . Porter, retiring NHI Personnel Officer, nesota will be able to expand its sleep latency, and the total sleep mental health services program and time did not differ significantly for Human Rights Committee ot o farewell porty given in he r honor. the two sub-groups. - Photo by Jerry Hecht. provide new services." To Provide Medical Aid The mental health planning proc­ This finding is contrary to the ess is a oomplex one, Dr. Yolles prevalent clinical impression that The Metropolitan Washington ignorance or racial discrimination. said, because planning of such sleep disorder is restricted to the chapter of the Medical Committee The Metropolitan Washington comprehensive scope has never be­ early phase of schizophrenia. for Human Rights will conduct a chapter has been asked to help con­ fore been initiated by the States. Studies such as this use sleep health education program and di­ duct a health project in two ru.ral and dreaming characteristics of agnostic clinic in rural Virginia Virginia counties southwest of schizophrenic patients as an instru­ this summer. Richmond since this area has an Manufacturers shipments of bio­ ment toward understanding the The Medical Committee for Ru­ insufficient number of medical per­ logical products were valued at pathology of this illness. man Rights is a national organiza­ sonnel. $155 million in 1963, 29 percent These findings were presented by tion created in 1964 to provide Doctors, nurses, dentists, psy­ higher than 1958, according to a Dr. Irwin F einberg, Richard Kores­ medical care for civil rights work­ chologists, social workers and other preliminary report of the 1963 ko and Dr. Fred Gottlieb, of the ers in the south. It also seeks to health workers who w ish to volun­ Census of Manufactures just issued Clinical Neurophannacology Re­ help people in all sections of the teer their set-vices may contact Dr. by the U.S. Department of Com­ search Center, NIMH, in Compre­ country who are deprived of prop­ David Savitz, Building 4, Rm. 122, merce's Bureau of the Census. hensive Psychiatry. er medical care through poverty, Ext. 64193. Page 8 June 15, 1965 THE NIB RECORD FLAG DAY DBS Researchers Study (Continued f rom Page J) blue is flown for the highest flag Rubella Virus Infection rank officer on duty that day. The Deputy Surgeon General's outdoor In Rhesus Monkeys flag is the same design. Preliminary experiments with A solid blue flag with the PHS pregnant rhesus monkeys indicate Corps Device in white is the Sur­ that, analogous to the human dis­ geon General's. It is flown when­ ease, rubella virus infection occur­ ever Dr. Luther L. Terry is on the ring early in pregnancy may 1-esult NIH reservation on official busi­ in placental infection. ness. In this e\'ent, it replaces the The rhesus monkey has been Assistant Surgeon General's flag. shown to be a sensitive laboratory On Saturdays, Sundays, and hol­ host for the study of rubella virus idays, the yellow PHS flag with t he As o result of on NIH Record feature (April 6 , 1965) an the emergency com­ infection. This study indicates that blue seal flies alongside the Stars munications system maintaine d he re, the Medical Tribune asked the Office of this animal has great potential as and Stripes. The plain solid yeUow Research Information to set up o "mack emergency" picture story showing a model for exploring methods of flag denotes quarantine anywhere the cooperotive efforts of the Employee Heolth Service, the Guard Force ond controlling the disease in humans, in the world. Fire Deportment in handling an e mergency situation. They sent contract pho­ particularly the rubella-induced Upon due notice of the death of tographe r Fred Ward to capture the story on film, for publication sometime congenital defects in children. a high ranking official or former next month. This sequence of pictures, taken by Donald Nusbaum of the Plant Inoculation of rhesus monkeys official of the Federal Government, ·with rubella virus by a variety of­ the flag of the United States and routes produced an infection viro­ the Public Health Service (yellow) logically resembling human rubella. flag are flow11 at half mast for a Similarities Noted period of one to 30 days depending on tJ,e official mourning period. Similarities included the pres­ ence of virus in the blood, nose, Other Rules Explained thxoat, and intestinal tract during The flags of the Surgeon Gen­ the first two weeks of infection, e1·al, Deputy Surgeon General, or and the subsequent development of an Assistant Surgeon General a1·e immunity. at half mast only in the event of Experimental infection w as death, while on active duty, of that found to be moderately communi­ officer. cable to susceptible monkeys. While Also, the Director of NIH can rash and other symptoms did not order the America11 flag to be low­ appear in the infected monkeys, ered to half mast at N IH on any many human infections are simi­ occasion which he considers an ap­ Safety Branch, a s photographer Word snapped the action, shows the procedure larly inapparent and both the ap­ propriate one. followed in one type of emergency. In upper left picture, me mbe rs of the Fire parent and inapparent infections PHS flag rank officers (pay Deportment rescue squad prepare to answer the alarm. Upper right, eme rge ncy can be readily studied by current grades 07 and above) may display treatment is being given the "casualty." lower left and right, the patient virologic techniques. their appropriate flag in their of­ following on-the-scene emergency treatment phoned in by EHS via "wo lkie­ This experimental animal model fices. In addition, they are author­ tolkie," is carried to the stretcher and brought by ambulance to the EHS has been used to examin1i two areas ized to fly their small distinguish­ emergency room in Building 10 for definitive treatment by physic ions. of special importance: the effect of ing automobile flag on occasions of rubella virus on the central ner­ ceremony, when participating in NIMH Publishes Reports of '63 Research Findings vous system, and the effect of in­ parades, or when performing offi­ fect.ion during pregnancy. cial visits to stations and activities Research results reported to the The pamphlet's discussion of bio­ Inoculation of rubella virus into under thei1· jurisdiction. National Institute of Mental Health logical factors includes the genetics the central nervous system did not On ceremonial occasions, the flag during 1963 are summarized in a of behavior, psychosomatic ill­ produce clinical symptoms or path­ of the senior rank official present new publication, "Mental Health nesses, the biochemistry of mental ologic evidence of inflammation of is displayed ,vith the United States Research Findings 1963,'' issued by illness, psychopharmacology, and the brain ( enoephalitis). and Public Health Service flags. the Public Health Service. progress in understanding and Virus Persists All indoor flags have a fringe It incorporates information ob­ treating alcoholism and drug addic­ trim on the three sides not attached tained from gran~supported stud­ tion. A large section is devoted to Despite this, the virus persisted to the flagstaff. The trim, cord, and ies in the four principal areas of new knowledge of the structure and in the spinal fluid for at least 32 tassel always match the color of mental health research-biological functions of the brain. days after inoculation, long after the flag's seal or corps device. The factors, developmental disorders, Studies of child development-­ it had disappeared from the throat only exception is an interwoven diagnosis and treatment, and socio­ from t he mother's influence on her and blood, and the animals had de­ blue and white cord fo1· the Deputy cultural problems. infant to the origin of occupational veloped antibodies. This persistence Sw·geon General. Prepared by the Program Analy­ interests- are presented, together in the central nervous system was sis Section of the NIMH Research with reports on sources of aggres­ considered to be a remarkable phe­ Grants Branch, this publication is sion in delinquents and effective nomenon. Dr. Minton Wins PHS one of a series designed to dissemi­ ways of treating adolescent delin­ In preliminary expel'iments two Clinical Society Award nate the findings of the Institute's quents. monkeys inoculated early in preg­ nearly 2,000 investigators in its nancy expe1;enced rubella infection Dr. John P. Minton, Clinical As­ The effects of aging on intellec­ which spread to involve the prod­ sociate in the Surgery Branch of tual and emotional functioning ucts of conception. the National Cancer Institute, re­ work reported in the paper, "Pulsed a re also covered. These filldings suggest the po­ ceived an award for his presenta­ Laser Energy-An Adjunct to Can­ Single copies of "Mental Health tential value of the primate host t ion at the recent ,annual meeting cer Surgery." Research Findings 1963,'' PHS Pub­ for studies concerning the patho­ of the United States Public Health Dr. C. H. Dahl from the PHS lication No. 1136, can be obtained genesis and prevention of matern­ Service Clinical Society, held at the Hospital in San Francisco was co­ without charge from the Public al-fetal rubella. Staten Island Public Health Hos­ winner for his paper, "Experimen­ Health Service, Washington, D.C. The work was done by Drs. Paul pital. tal Ascites." 20201. E. Phillips, Paul D. Parkmen, Ruth Dr. Minton is the first NCI affili­ Along with the surgery award, Multiple copies may be purchased L. Kirschstein, and Harry M. ate to win an award from the Clin­ the society gave first prizes in den­ from the U.S. Government Printing Meyer Jr., all of the Division of ical Society for research done at tistry, pharmacy and medicine, se­ Office, Washington, D.C. 20402, for Biologics Standards. Dr. Phillips NIH. He was selected to share the lected from more than 240 papers 25 cents each, with 1·ates available presented the findings at the recent first prize for surgery research for presented at the meeting. for orders exceeding 100 copies. annual meeting of F ASEB.