April 16, 1968, NIH Record, Vol. XX, No. 8

ecor U . 5. DEPARTMENT OF April 16, 1968 N ATIONAL INSTITUTES OF H EA L TH H EALfH. EDU CATION. AND WELFARE Vol. XX, No. 8 P U B L IC HEALTH SERVICE 2 New NIH Components, Five NIH Employees Honored at April 11 Dr. S. Spiegelman BHM and NLM, to Add Departmental Annual Awards Ceremony Dr. Carl M . Eklund, who recently retired from the National linstitute Is Dyer Lecturer Over 1,000 Employees of Allergy and I nfectious DiS<'ases' Rocky Mountain Laboratory, was 'l'he Bureau of Health Manpow­ awarded the Distinguished Service Medal at the DREW Annual Awards Here April 24 er , one of the two new components Ce1·emony, April 11. assigned to NIH under the April DI'. Eklund was honored fol' Dr. Sol Spiegelman, University 1 reot·ganization of DHEW health "outstanding research in arbivirol­ Dr. Camerino Appointed of Illinois microbiologist who 3 activities by Secretary-designate ogy and pioneer investigations of years ago demonstrated in t he test Wilbur J. Cohen, will add 713 full­ slow viral infections." The award, NIAMD Branch Chief tube how a viral nucleic acid repli­ t ime and 189 other than permanent the highest De­ Dr. G. Donald Whedon, Director cates itself, will deliver the 17th emnloyees to NIH rolls. partmental honor of the National Institute of Arth,-i­ annual Dyer Lectuxe on April 24. The Bureau was established by for Commissioned His lecture, "Test-tube Studies the then Secretary, John W. Gard­ Officers, was pre­ tis and Metabolic Diseases, recently announced the appointment of Dr. of a Self-Duplicating RNA l'llole­ ner, on J.muary 1, 1967. Its mis­ sented by Secre­ cule," will be p resented at 8 :15 sion, as determined by a task force t:ny-designate Wil­ Pat W. Camerino as chief of the set up by Surg. Gen. William H. bur J. Cohen. Analysis and Evaluation Branch, Extramural Programs. Stewa,·t, is to "concentrate the rap­ Receiving the idly growing Federal support of Nation's hiv;hest The Analysis and Evaluation programs designed to provide ad­ civilian honor, the Branch develops data for NIAMD's ditional and better qualified man­ D i s t i nguished extramural program and policy power for health." Service A ward, Dr. Eklund formation, and appraises program The need for such an orgtmiza­ we re Dr. Marshall N irenberg, Na­ needs. Dr. Camerino is also, respon­ tion had been defined by President tional Heart Institute; and Dr. sible for the Institute extramural Johnson in a letter of September Joseph E. Rall, National Institute data storage and retrieval system. 29, 1966, to Mr. Gardner, in which of Arthritis and Metabolic Dis­ Received Ph.D. in '61 eases. he said: "Our examination of the Dr. Camerino received the Ph.D. Nation's health problem makes The annual awards ceremony degree in biochemistry in 1961 at honors employees who ex­ clear that the most critical need is DHEW Cornell University. emplify public service at its best. in the manpower field." He was a PHS postdoctoral ( S ,r COMPONENTS. Page 8) (See 11 WARDS. Page?) trainee in the Department of Bio­ chemistry at Dartmouth College NICHD Establishes Pygmy Goat Colony Medical School where he investi­ gated electron transport. From For Intrauterine and Perinatal Studies 1963 to 1965 he continued his re­ By Lloyd Blevins search and was assistant professor Under a research contract from the National Institute of Child Health in the Department of Chemistry anc.l Human Development, a breeding- colony of pygmy goats has been and the Science Research Institute Dr. Sol Spiege lmo n, noted microbiolo­ established at the University of Oregon Medical Center in Portland by at Oregon State University. gist, will discuss "test-tube studies of a of Dr. In Ul65, he joined the Grants As­ team scientists headed by a self-duplicoting RNA molecule." James Metcalfe. st1·ains of the East African dwarf Rociate Program at NIH, and in 1966 became assistant director of 'T'he breeding colony of pygmy goat which came to this com1try p.m. in the NIH Clinical Center goats is descended from various by way of the German Zoological the NIAMD's Endocrinology Pro- gram. auditorium. Parks at Hanover and Berlin. Dr. Spiegelman will describe his Dr. Metcalfe is in the process of research leading to the discovery standardizing this goat as a lab­ Color Film on NIH Research of how a virus replicates and the successful duplication of a viral oratory animal in or de1· to increase To Be Telecast April 21 its value fol' studies in r,lace ntal, RNA (ribonucleic acid, the genetic fetal, and cardiovascular physiol­ A color film story of NIH material of certain viruses) which ogy. nersonnel and their contribu­ reproduces in the test tube in the As part of the standardizing tions to medical research, en­ same way the virus replicates in process, in depth studies of tihc titled "The Miraculous Pool," a living cell. nutritional, metabolic, and genetic will be telecast for th"' first Dr. Spiegelman has been profes­ chm·acteristics of the pygmy goat Lime in the Washington area sor of microbiology at t he Univer­ will be carried out in cooper ation Sunday, Ap1·i l 21, at 8 a.m. on sity of Illinois since 1949. His re­ with members of the Animal Sci­ Station WTOP-TV (Channel search interests include the gene­ ence Department of Oregon State 9). tics and biochemistry of micro­ University at Corvallis. The 28-minute film f eatures organisms and the mechanism of scenes in laboratories of the Studies in tmnsy,lantaLion of gene action. National Institute of Allergy His work in 1965 marked t he Dr. James Metcalfe crodles one of fcrti li?.ed ova a1-e plannned with and Infectious Diseases and first t ime a gene had been made the pygmy goats who have become a view to developing a means by the wards and operating rooms to replicate in the test tube, an fovorites of the stoff ot the Oregon which the size of the pygmy goat of the Clinical Center. achievement which has enabled bi- Medico) Center. (Se• GO.4.T COLONt , Pa11e G) (Scc DU. SPIEGELMAN, Page 7) Page 2 April 16, 1968 THE NIH RECORD

Published bi-weekly at Bethesda, Md., by the Publications and Reports Branch, Office of Information, for the information of employees of the National I nstitutes of Health, principal research center of the Public Jlealth Service, U.S. Department of Hea lth, E ducation, and Welfare, aud circulated by request to all news media and interested members of the medical- and science-related fields. The NIH Reco.rd content is reprint­ able without permission and its pictures are available on request. NIH Record Office...... Bldg. 16, Rm. 212. Phone: 49-62125 Associate Editor ...... Frances W. Davis Stoff Correspondents Tony Anastasi, DRS; Bari Attis, NINDB; Lloyd Blevins, NICHD; George Displaying Sustained Superior Wark Pe rformonce owards, six employees of Bragaw, NHI; Dale Carter, DRMP; Mary Anne Gates, NI~MD; Sue the Clinical Center's Departme nt of Environmental Sanitation Control ore Hannon, NIDR; Bowen Hosford, CC; Walter Jacob, OAM; Sheila Jacobs, shown with Gordon Gamble, Operations Section chief Immunization era l Service," an employee organi­ NEWS from zation that has been granted for­ William M. Cissel, a Government To Begin Next Week mal recognition has the right to be electrician for the past 27 years, turns "lights out" on his Federal The Employee Health Service has consulted on matters of interest announced the following smallpox PERSONNEL to its members. caree'l· April 22. Mr. Cissel will 1-etire from the P lant Engineering vaccination schedule for NIH per­ ANNUITY BOOST Such consultation involves dis­ sonnel, including those working in Under a provision of the Civil cussions between management and Branch, Division of Research Serv­ ices. off-reservation buildings: Service Retirement Act, annuities the organization's representatives Building 10 Health Unit, Room are automatically increased re­ He came to NIH in 1941 when to in formulating and implementing B2A-06, between 1 :30 and 4 :30 flect changes in the cost of living personnel policies and practices, six buildings dotted the 1·eserva­ tion and the electric shop was lo­ p.m., April 22, employees with last as determined by the Civil Service and matters affecting working con­ name initials A through D; April Commission from the Consumer ditions that are of concern to its cated on the ground level of Build­ ing l, where personnel offices are 23, E through H; April 24, I Price Index issued each month. members. thrnugh M; April 25, N through S; Such increases are made when­ 110w found. During his NIH career, COORDINATED WAGE SYSTEM and April 26, T through Z. ever the price index shows a level he has wo11 five employee sugges­ for 3 consecutive months at least Recently all PHS employees in tion awards. Vaccinations for the Building 10 3 percent above the index for the the trades and labor occupations Mr. Cissel and his wife will cele­ night staff will be given daily from month used in determining the last received a memo from the Director, brate their 39th wedding anniver­ 8 to 9 a.m. in accordance with the annuity increase. Office of Personnel, pointing out sary next Tuesday, April 23, the above schedule. the basic features of the new Co­ As a result of such a rise in day after his retirement. Locations Listed ordinated Federal Wage System. A resident of Arlington, Va., the Consumer Price Index during The featU1·es of the new wage sys­ Building 31 Health Unit, Room the 3 consecutive months-Decem­ Mr. Cissel was bo1·n in 1906 in tem outlined in this memo include: B2B-34, between 1:30 and 4 p.111. ber, January, and February- a cost Washingt.on, D. C., where he at­ on April 29 and 30. 1. Specia l emphasis on employee tended school. His first job was as of living annuity boost of 3.9 per­ and union participation in the sys­ Westwood Building Health Unit, cent is scheduled to become effec­ a pressman in 1922. He began his tem; career as an electrician the fol­ Room 28, between 9:30 a.m. and tive on May 1. 12 noon and between 1 and 4 p.m. Other Features Noted lowing year. This annuity increase will apply on May 1. 2. A single system for all Fed­ After retirement Mr. Cissel to all employees retiring on or be­ Building 13 Health Unit, Room eral agencies to insure equitable plans to travel, study philosophy, fore April 30, and will be reflected 2910, between 1:30 and 4 p.m. on wage rates for all employees in and enjoy his two childrnn and in annuity checks received 011 June May 2 and 3. 1. Accordingly, an employee who the trades and labor occupations; nine grandchildren. wishes to take advantage of this 3. The development of w a g e Wiscon Building, basement level increase must be separated by rates throug·h local wage surveys; Film, 'David Copperfield,' near BlA-10, between 1 :30 and 4 April 30. 4. The issuance of uniform poli­ p.m. on May 6. Additional information on the cies, procedures, and job classifi­ At CC April 20 and 21 Barlow Building, Room 8C-05, cation standards by the CSC; between 1:30 and 4 p.m. on May 7. cost-of-living increase is available "David Copperfield,'' a film por­ in Institute/Division Personnel Of­ 5. Conversion to the new system NBOC #2, Room 213, between without loss of pay; trayal of the Charles Dickens 1:30 and 4 p.m. on May 8. fices. classic, will be shown on Saturday, 6. Coverage of most wage rate Mental Health Study Section, UNION RECOGNITION April 20, at 8 p.m., and Sunday, employees under common wage April 21, at 7 p.m., in the Clinical Adelphi, Md., at 2 p.m. on May 9. Dr. Ronald E. Myers, chief of Employees in other outlying schedules including laundry and Center auditorium. Laboutory of Perinatal Physiolo­ food service workers as well as areas may receive vaccinations at gy, National Institute of Neuro­ The movie is open to CC patients those in the trades and in super­ and their guests and to NIH em­ any of the locations at the times logical Diseases and Blindness, re­ visory jobs; and specified. ployees and their families. cently accorded formal recognition 7. Continued coverage under spe­ Vaccinations wjll not be adminis­ to Lodge 2641, American Federa­ cial schedules of employees in tered to pregnant women, to indi­ tion of Government Employees printing and lithographic jobs, for­ flee of Personnel, PHS, installation viduals with chronic dermatitis, (AFGE) for the employees at the eign nationals in foreign areas, and of this system will be especially those receiving immunosuppressive Laboratory in Puerto Rico. a few other groups presently cov­ significant in eliminating inequities drug therapy, or those with leu­ Under the provisions of Execu­ ered by special schedules. in job grading nnd pay administra­ kemia, lymplhoma, ot dysgamma­ tive Order 109881 "~rnployee M&n- According- to the Director, Of- tion, globuliMrnia. • THE Nlll RECORD April 16, 1968 Page 3 Dr. Norman P. Salzman Construction Projects Near Completion, NIH Custodial Employees Named NIAID Lab Chief 900,000 Square Feet of Space Added Vote on Representation Dr. No1·man P. Salzman has been named chief of the Laboratory of By Union on April 26 Biology of Viruses, National Insti­ An election to determine exclu­ tute of Allergy and Infectious Dis­ sive representation for the employ­ e:ioos, by D1·. Dorland J. Davis, In­ ees engaged in custodial laboring stitute Direct or. duties has been scheduled for Fri­ Dr. Salzman, at NIH for 15 day, April 26, at the request of the years, has been acting chief of the Washington Area Metal Trades laboratory since the retirement last Council, AFL-CIO. October of Dr. Karl Habel. T h i s election will determine A biochemist, Dr. Salzman joined whether or not the WAMTC shall the National Heart Institute in be recognized as the exclusive rep­ 1953 and NIAID in 195·5. Since resentative of all non-supervisory 1961 he has been chief of the Cell employees who perform custodial Biology Section. duties. He is an editor of Journal of NIMH Child Reseorch Center will occupy southwest corner of reservation. Virology, a publication of the These include employees of the: By Kothleen DuBois American Society of Microbiology (1) Department of Environmental initiated last year, and a member All of the surgery at N IR is not being done in operating rooms. For Sanitation Control, Clinical Center; of the Editorial Board of Journal several years the rese1vation has looked as if it were undergoing major (2) Property and Supply Section, of Bacteriology. He is author or surgery- 01· at least a face-lift. New bL1ildings have sprung up on th1·ee Administrative Branch, Clinical coauthor of 30 articles. of the four comers and at various spots in between, and a netwo1·k of Center; and (3) Housekeeping Sec­ trenches criss-cross the area, tion, Office Services Branch, Office bringing necessary underground occupied. of Administrative Management. utilities to all buildings. In mid-Ju.ne the NCI Virus Iso­ lation Facility, Building 41, is The election will be held by Now, as summer approaches, secret ballot on April 26 between many of the projects are nearing scheduled for completion, to be 2:30 and 6:30 p.m. at two polling completion, and the "patient" may followed in August by Building 34, soon look normal again. a refrigeration plant that will pro­ places: Wilson Hall, Building 1, for vide the necessary chilling capacity OAM employees; and the 14th floor The Division of Research Serv­ auditorium of the Clinical Center ices, responsible for the design and for air-conditioning of many of the new buildings. for Clinical Center employees. Eli­ construction of these new facilities, g ible employees will be allowed to has summarized current and plan­ With the refrigeration plant op­ erating, August and September vote on their own time or on offi­ ned activities. cial time. should also see the completion and Project Complet ions Listed beginning QCcupancy of the largest Voting Encouroged The most recently completed single project now underway: the The ballot will give each eligible project is the library relocation NCI-NIMH/NINDB complex of a voter a choice of 1·epresentation by and cafeteria extension in the cafeteria building and two labora­ either the Metal Trades Council Clinical Center. Although it will tory buildings. They are designated and its affiliated Locals, AFL-CIO, be about 6 more weeks before the Buildings 35, 36, and 37. or "no union." All eligible em­ cafeteria's old seating area is ren­ Less Inconvenience Anticipoted ployees are encouraged to vote in Or. Normon P. Solxmon is o n editor ovated, the new section is now open for business. When completed, By t he middle of September, order for election results to reflect of the Journol of Virology. accurately the wishes of the ma­ there will be three serving- lines much of the utilities extension jority. A member of the American and 650 seats available. work will be finished, at least that part of the project which has Foi· the election to be valid, Academy of Microbiology, Dr. Salz­ Another project to be completed man's interests include control crossed roads and parking lots and either of the following criteria this month is the addition to Wing has caused some inconvenience to must be met: (a) a representative mechanisms of cell growth, mode D of the Clinical Center. The 6th of replication of animal viruses, drivers. vote by a minimum of 60 percent floor has bee:n extended to the full of those employees present at the and the effect of antimetabolites on length of Wing D, and a 7th floor The last of the projects now un­ virus 1·eplication. He is also a pro­ der construction, the General Office time of the election and eligible to has been built, adding 13,800 gross vote, or (b) more than 50 percent fesso1·ial lecturer in microbiology square feet of space and easing Building Extension, 31C, is due to at the Georgetown University be finished in October. of the employees eligible to vote the urgent need for more space must cast ballots for one choice. School of Medicine. for clinical research. All of the foregoing means that Dr. Salzman received a B.S. de­ In Baltimore, a laboratory huild­ over !)00,000 gross square feet of Further information concerning gree from City College of New new space will become available the election will be posted on offi­ in11: for the NIGRO Gerontology York, an M.S. deg1·ee from the during 1!>68. cial bulletin boards. Election re­ Unive1·sity of Michigan, and the Research Center is being completed One might think that tJhis was sults will be announced early in Ph.D. degree from the University on the grnunds of the Baltimore the end of construction at NlH, but May, after tabulation of the bal­ of lllinois. City Hospitills and is now being (See CONSTRUCTION, Pago 5) lots.

Multilevel structure plonncd fot porking neor Building 31. C wing is ot right. Multilevel porking facility to be lacoted near Buildings 3 5, 36, ond 37. Page 4 April 16, 1968 THE NIH RECORD NIH Historian Records Past for Posterity, Dr. Peter H. Forsham NIDR Investigators Note Named to DRFR Council Immune Response Site Makes Background of Events Come Alive Dr. Peter H. Forsham, Profes­ sor of Medicine and Pediatrics of In Periodontal Disease the University of California School cf Medicine, San Francisco, has Immunological reactions to bac­ been named to the National Ad­ teria living in diseased gum tissues visory Council on Health Research a1--e suspected of playing a signifi­ Facilities for a 4-year term begin­ cant part in periodontal disease ning July 1. which causes loss of teeth in older people. Fresh evidence for this theory house of kJ10wledge about NIH's history. A great many interviews and clues to where more evidence are conducted with NIH staff mem­ may be found h.ave been uncovered bers who have been at NIH for a in studies by the National Institute number of years and are still em­ of Dental Research. ployed, as well as retired em­ In certain bacteria, lipopolysac­ ployees. charides in the cell walls provoke Dr. Miles' gl'eatest problem with allergic and other immune re­ these retirees is that, contrary to sponses. An exh·act of this cell the usual conception of retirement, wall material from Escherichieleton which can be filled out by as when the same small dose is in­ records. a sig-nificant part in rounding out t':e )HH story. Some of t.liese em­ jected into the lining of the mouth, Dr. Miles' main purpose in mak­ ployees we re around in 1930 when antibody-forming cells are found ing tape recordings is to get a ~he Hygienic Laboratory was re­ only in the regional lymph nodes. well-rounded pottrayal of the back­ designated the National Institute The investigalors believe that g round history of NIH and to make of Health. very small amounts of bacterial the stories of the people who have products entering the body through D,·. Mi les has been the NIH His­ sores or breaks in the gums are played a vital role in past events torian since 1962. He received the here come alive. quite capable of stimulating local n.s. degree in chemistry from the antibody production in l'egional To accomplish this, Dr. Mi les Philadelphia College of Pharmacy has the pe1·son who is being inter­ lymph nodes and perhaps at the and Science, the M.S. degl'ee in actual site of inflammation. viewed, tell his story in chrono­ chemistry at Pennsylvania State Jogical order from his youtlh. In Un iversity, and the Ph.D. degree this way he learns why a particu­ in History of Science from Har­ 5;; historical articles and one book. lar career was chosen 01· reasons vard University. He is a member of the Ameri­ for coming to NIH. He has worked as a research can Chemical Society and the By skillfully drawing out a doc­ Dr. Miles is interested in an anecdote chemist, taught chemistry at P{!nn American Historical Association, tor's philosophy of science, his out­ about NIH's past as his secretory, State, written history for the Army a nd is cunently chairman of the side activities, and hobbies, or sug­ Mory B. Abernethy, types a table of Chemical Corps, the Polaris Proj­ Chemical Society of Washington's gesting that he relate appropriate contents for future reference. ect, and NIH. H e is the author of History of Chemistry Committee. THE NIH RECORD April 16, 1968 Page 5 CC Brochure Describes Dr. Keresztesy Retires; CONSTRUCTION CCll1Teer O pportunities CC Blood Donations Noted, (Continued from Pa-ge 9) 4 Join 'Gallon Donor Club' in Medical Technology Research Contributions it isn't. According to Chris A. The Clinical Center Blood Hansen, DRS Director, there are Cited at Farewell Fete Bank reports that 205 units of many new projects that may be Friends and associates of Dr. blood were received from NIH moving from the design stage into John C. Keresztesy bade rum an donors in March. During the construction t his year and next. oL7cia l farewell at a 11etirement same period, CC patients 1·e­ Two projects that will be espe­ pa,·ty held March 27, but many ceived 1,836 units of blood. cially welcome arc the multilevel hor,e to remain in touch. Four NIH staff members parking structu1·es now being de­ Dr. Keresztesy, who retired have joined the "Gallon Donor s igned. One is for the west side of March 31 after more than 20 years Club." They are: Ralph A. the campus, to park 825 cars, and with t.i:e National Institute of Ar­ Bredland, DRS; Dr. James D. the other, on the cast side nea,· thritis and Metabolic Diseases, will MacLowry, CC; Paul W . Building 31, to park 6ri0 cars. c011tinue to reside at nearby Ross­ O'Briant, SMB; and Howard Some of the other projects now moor, Md., where he and his wife W. Spence, CC. being designed are the NTC HD moved recently. Tie~earch Facility, Building 33, to At t he party, NIAMD Director be located on the northwest corner G. Donald Whedon spoke brieAy P1·ior to joining NIAMD in 1947, of the reservation; the N IMH :cbout Dr. Keresztesy and his work, Dr. Keresztesy was with the Can­ Child Research Center, Building ,md read a sampling of te'.•egn1ms cer Research LabomtoTy at Mt. 55, which will occupy the south­ Diane McDonough (standing) is one tnd letters sent to him by formel' Sinai Hospital in New York City, west corner; an extension to the of five staff medical technologists colleagues and well-wishers around studying the !'Ole of folic acid in Isotope Laboratory, Building 21; featured in a new Clinical Ce nter bro­ tlce country. cancer chemotherapy. and a combined service faciHty. chure . She watches Sylvia Gersch From l!J34 to ) 945 he was head The latter consists of a warehouse, plant a throat culture .-Phato by of the Nutritional Research Lab­ a fire department building, a ve­ Roy Perry. oratory at Merck and Company, hicle repai1· building, a fuel dis­ Inc., Rahway, N. J. He worked pensing area, and extension of the An illustrated brochure for medi­ the1·e on the isolation and chemis­ service tunnel. cal technolog·ists, "The Frontier of try of various B vitamins, thia­ DRS Coordinates Plans Clinical Pathology," was published mine, pyridoxine, pantothenic acid, recently by the Clin ical Center. biotin and rhizopterin , a fo1'm of Not all NIH building activity is In the brochure five technolog·ists folic acid. confined to the reservation, how­ ever. DRS is also coordinating the and a former technician (now a Investigated Thiamine microbiologist) discuss the satis­ design of such far-flung projects factions and opportunities in work­ While graduate students at Co­ as: the N'IXDB/NICHD Research ing at the CC's Cl inical Pathology lnmbia University, he and his wife, Facility at the Puerto Hico Medi• Department. Marion, we1,e associated with D1·. cal Center, San Juan; and a facil­ R. IL \Yilliams in developing the ity at Sabana Seca, Puerto Rico, Those interviewed for the book­ first large-scale isolation of thia­ for housing laboratory primates. let were Strother (Pat) Dixon, mine and in chemical studies lead­ Also, major improvements tc Suzanne Garges, Carol Huber, Di­ ing to the elucidation of its struc­ plant facilities at KIAID's Rocky ane McDonough, Diane Mizelle, and tt11·e. Dr. Keresztesy received the Mountain Laborntory, Hamilton, Dr. Charles Zierdt. Dr. Jchn C. Keresztesy and his wife, Morion, stond before decorated cake Ph.D. degree in 1!)35. ~tont., a nd the Middle Atlantic Re­ Copies of the publication may be expressing the thoughts of coworkers Dr. Kcresztesy had been chief search Unit in Panama; a maste1 obtained from the CC Infor mation at th~ recent retirement party in his plan for the National Environmen­ Office, Bldg. 10, Rm. l N-248, Ext. of the Laboratory of Nutrition honor.-Photo by Ed Hubbard. and F,ndocrinology, NIAMD, since tal Health Sciences Center at Re­ 62563. search T1·ianglc, N . C.; and con­ Dr. Kc1·csztesy's studies at NIH l!)fi:-J. Prior to that he had served as chief of the Laboratory's Sec­ tinued expansion at t he NIH Ani­ on the nature o[ folic acid, Dr. mal Center in Poolesville. Dr. Kurt Salomon, NCI, \ilhedon said, led to the first iso­ tion on Fractionation and Isola­ tion. Accepts Post in Nigeria htion and charactel'ization of a coenzymc form of this vitamin, G­ Retirement, said Dr. Kercsztesy, tage of t he go] f course at Ross­ Dr. Kurt Salomon has resigned formyl tetmhydrofolic acid, from w ill e nable him to pursne his study moor, and practice pool in the hope his position with the National Can­ a natural source. of organ music more intensely. He of eventually beating his son at cer Institute to accept an appoint­ H is extensive investigations on also pla11s lo travel, take advan- this game. ment in Nigeria. the unknown forms of folic acid He will serve as professor and in biological materials culminated head of a new Department of Radi­ in the discovery of 5-mcthyltctra­ ation Biology and Radiotherapeu­ hycfrofol ic acid. tics at the Medical College of the Mechanism Explained University of Lagos, Nigeria. The isolation, chemical charac­ Dr. Salomon, scientific special­ terization, and synthesis of this key ist, Awards Review and Technical cofactor i11 folate metabolism by Administration Branch, joined NCI Dr. Keresztesy and Dr. Kenneth in 1!)64. H e is no strange!' to Af­ Donaldson, formerly of NIAMD, rica, having spent 2 years at the led not only to the explanation of NCI-supported West Africa Re­ t he mechanism of methionine bio­ search Unit in Ghana, studying synthesis hut also to an under­ the relationship between schistoso­ :;tanding of the obscure relation­ maisis and bladder cancer. ship between folic acid and vita­ Dorn in Frankfort-on-Main, min Bi,. Ge ,-many, in 1898, he became a Dr. Kercsztcsy's studies have naturalized citizen in 1943. continued in this area, Dr. Whedon Dr. Salomon will establish the added, and more recently the 1rn­ James B. Davis, chief, Supply Management Branch (right), presents sustained depaJ·tment with the aid of two ture of the most elusive forms of supe rior work performance award to the Administrative Unit, Research Con­ young Nigerian scientists and an folic acid, the polyglutamates, are tracts Section. They are from left (standing) Ted Dowson, Gino Caruso, Dor­ Australian technician, and will being investigated. This work will othy Johnson, Jocn Fazenbake r, Mory Corbett, and Marguerite Dreye r. Seated supervise the design of a facility be actively pursued by his cowork­ are Linda Andrews, Millie Applestein, and Pot Scales. Jack Nance, Mary to house the radiation unit. ers. Newkirk, and Mary McHugh are not shawn.-Photo by Ralph Fernandez. Page 6 April 16, 1968 THE NIH RECORD Dr. Morris; Biochemist Dr. Whitford Appointed To Retire From NCL To NIAID Laboratory The National Instit ute of Al­ Joined Institute in '38 lergy and Infectious Diseases has Dr. Harold P. Morris, a member announced the appointment of Dr. of the research staff of the Na­ Howard W. Whitford to the re­ tional Cancer Institute since its search staff of its Rocky Mountain founding and authority in the field Laboratory in Hamilton, Mont. of cancer biochemistry, will retire Dr. Whitford attended Oklahoma this month from his post in the State University and Texas A & M Laboratory of Biochemistry. University, receiving the B.S. de­ In recent years Dr. Morris has gree in animal science in 1963 and developed in the laboratory a lar ge the D.V.M. degree in 1964. spectrum of transplantable liver Dr. Whitford joins the Labora­ tumors in inbred strains of rats. tory's Comparative Pathology Sec­ These t umors deviate much less tion whe re he will assist D1·. Wil­ from normal liver tissues than li am J . Hadlow inv-estigate the de­ t hose previously produced in any velopment of viral infections mark­ laboratory. ed by extensive time lapses be­ This discovery has established a tween initial infection and clinical biological model in which minimal How's this for size? The part of the picnic table visible in the upper left hand signs of disease. differences between the metabolism corner offers a good comparison for judging the actual height of this pygmy Several "slow virus" diseases of of normal liver and liver tumors goat.- Oregon Medical Ce nter photos. animals are being studied because can be determined. they may bea1· an important rela­ Dr. Morris attended the Univer­ GOAT COLONY Dr. Gallelli to Receive tionship to chronic degenerative sity of Minnesota and Kansas State (Contin.urd fro1n Pane 1) diseases of man, such as multiple College where he received the B.S. APhA Award for Paper sclerosis. and M.S. degrees in ag1·icultural l:c:·d can be increased mol'e rapid­ On Amphotericin B biochemistry and animal genetics. ly. Superovulated female pygmies Counterparts Possible in Man He returned to the University of will be mated wi th selected pygmy Dr. Joseph F. G-allelli, chief of Four of these diseases that may Minnesota as an assistant in bio­ s ires and fertilized ova will be the Clinical Center Pharmacy De­ have biologic counterparts in man chemistry and completed the re­ t'.·a nsferred to receptive female partment's Pharmaceutical Devel­ are scrapie (a disease that natu­ quirements for the Ph.D. in agri­ Hubian (full-size) goats. opment Section, has been named rally affects sheep and, less fre­ cultural biochemistry. if the zygote transfer is suc­ to rece ive the 1967 Military Sec­ quently, goats), encephalopathy of Dr. Morris began his Federal cessful, it could make possible mul­ tion L i t e r a r y mink, Aleutian disease of mink, career in 1931 as a research asso- tiple deliveries of newborn goats A ward from the and chronic interstitial pneumoni­ f·at had undergone prenatal de­ American Phar- tis of sheep. , elopment in available goats of maceutical Asso- In 1967 RML investigators re­ ~ifferent size. T he offspring would ciation at its an­ ported on the pathogenesis of scra­ ntill have t.he same genetic parents nual meeting in pie vi rns in mice. In thest! studies 1,nd approximately the same date Miami May 6. virus was evident in the spleen 4 of birt h. His paper, " As­ weeks after it was injeded into The studies planned seek to eval­ say and Stability the animals; it slowly spread to u:ite the e ffects of such a gesta­ of Amphotericin B other tissues and finally reached tional "foster home" on the off­ in Aqueous Solu- the centl•al nervous system 12 spring in terms of physiological tions," was deter- Dr. Gollelli weeks after inoculation. and behavioral development. mined to be the best original con­ Fatal progressive disease ap­ With t he growth of the colony, tribution to pharmaceutical litera­ peared following long continued an imals will be made available to tuPe s ubmitted by a member of presence of large amounts of virus ccicntists interested in the use of APhA's Military Section during in the central nervous system. The this species in intrauterine and Lhe past year. Tt was published in first sick mouse was observed 23 perinatal studies. the March 1967 issue of Drng In­ weeks after inoculation, the last The pygmy goat has several dis­ telligence. two became affected at 57 weeks. tinct advantages as an experi­ Dr. Ga!lelli joined the CC staff in 1962. His research interests are mental animal: it is herbivorous, Daylight Saving Time Begins can be easily t1·ained, thrives in a drug stability and chemical kinetics temperate climate, and is easily of drugs. At 2 a.m. Sunday, April 28 Dr. Harold P. Morris won Washington handled by female laboratm·y tech- Dr. Gallclli ,·eccive,1 the Rache­ On April 28 at 2 a .m., the Star award in 1950 for outstanding 1,icians. lor of Science Degree in Pl1armacy Washington Metropolitan Area civic work in Montgomery County. In addition, the fetus of the goat from Long Island Unive1·sity's will go on Daylight Saving He is still active in such work. is large enough to undergo fetal Brooklyn College of Pharmacy, Time. Employees are remind­ surgery and other manipulations and the M.S. and Ph.D. degrees ciate in the U.S. Bureau of Fish­ ed to set their clocks ahead impossible on smaller laboratory from 'l'emple University. eries investigating the nutritive one hour to compensate for the animals. He is past president of the Dis­ time change. properties of kelp meal. He worked Project Officer for the program trict of Columbia Sodety of Hos­ for the Department of Agriculture NIH employees working is Dr. Eileen G. Hasselmeyer, Di­ pital Pharmacists and is a mem­ from 12 midnight to 8 a.m. from 1934 to 1938 studying the rector, Perinatal Riol.ogy and In­ ber of the Academy of Pharma­ will work one hour less that chemical and physical properties of fant Mortality Branch, N ICHD. ceutical Sciences, APhA, and day as a result of the change eggs as related to cake making. American Society of Hospital and wi11 be charged one hour's He was one of the first investi­ Pharmacists. annual leave. With the change intei-national recognition. gators selected in 1938 to conduct back to Eastern Standard Time l·esearch in biochemistry at the Dr. Morris and his colleagues in the fall , employees working was awarded t he Superior Sel'Vice newly created National Cancer In­ were the first to succeed in pro­ this tour will be compensated ducing experimental cancers of the Award .from the DHEW for "a su­ stitute. For a number of years he for one hour's overtime. investigated the role of vitamins thyroid gland in animals-cancers perior series of scientific investiga­ and amino acids in the growth of which are also transplantable to tions of the mechanism of cancer mammary tumors in mice. Exten­ normal animals. causation." to the Howard University School of sive research also was conducted Dr. Morris is the author or co­ Upon retirement, Dr. Morris Medicine. He will also lecture to on the nutritive requirements of author of more than 230 scientific plans to continue his hepatoma re­ medical students in the field of normal mice. This work gained him papers. Besides other honors, he search on an NCI grant awarded cancer biochemistry. THE NIH RECORD April 16, 1968 Page 7 AWARDS NIAMD Basement Laboratory Ferments DR. SPIEGELMAN ( Continued from P1Joe l ) (Contin«ed !rem, Pagel) Howard F. Brubach, a biologist 1,000th Batch of Bacteria for Research ologists to study the evolution of with NIAMD's Laboratory of molecules. Physical Biology, and Guerry R. It may also make possible new Smith, chief of the Grants Man­ weapons fo~· control of viral dis­ agement Branch, Division of Re­ ea[es through knowledge of the search Grants, received 40-year differences b ~tween the replication Length of Service Awards at the of viruses and that of body cells. ceremony. Lettu re Established in '50 Dr. Nirenberg, chief, Laboratory The Dyer Lectureship was estab­ of Biochemical Genetics, NH!, was lished in 1950 to honor Dr. Rolla E. cited for his work in "clarifying Dyer on his retirement as Director the genetic code by showing the of the National Institutes of way information is coded into nu­ Health. The lectureship is admin­ cleic acids and used to rurect the istered by NIH and awarded an­ incorporation of specific amino nually to a scientist who has made acids into proteins." an outstanding contribution to Code Essentially Unchanged medical and biomedical research. A graduate in mathematics and The results of his and other in­ vestigations have suggested that physics of the City College of New most forms of life on this planet York, Dr. Spiegelman did graduate use essentially the same genetic study in cellular physiology at Co­ language and that few changes in lumbia University and received the this language have occurred dur­ Ph.D. degree in biology from ing the last 500 million years. David L. Rogerson (left) gives the 1,000th batch of bacte ria g rown in his Washington University. unit to Or. Reed Wickner of the Laboratory of Biochemical Pharmacology, He was a faculty member there Dr. Rall, Director of Intramural NIAMD. Behind the m is the 100-gallon fermentor in which the bacteria were until 1948, when he received a Pub­ Research, NIAMD, was honored g rown.-Photo by Ralph Fernandez. lic Health Service Fellowship at "for distinguished leadership in the University of Minnesota Medi­ administration of an extensive pro­ Since 1959, the Laboratory of Nutrition and Endoc,·inology, National cal School. gram of clinical and laboratory Institute of Arthritis and Metabolic Diseases, has been growing bacteria medical research and for personal at the rate of up to four batches a week for use in research projects at Wins Pasteur Award achievements in the field of thy­ NIH and other local institutions. Dr. Spiegelman won the Pasteur roid physiology." The lot that emerged from one Award of the lllinois Society for trients such as mineral salts, nitro­ Microbiology in 1963, was elected Mr. Brubach has been with NIH of the big fermenting tanks in the gen, carbon sources, vitamins, and since 1942 and wi th NIAMD s ince basement of Building 3 on March to the National Academy of Sci­ other things on which bacteda ences in 1966, and this year re­ 21 was basically no different from flourish were put in to the tank, ceived th e Bertner Foundation all the others, except that it was along with distilled water. the l,000t.h batch. Award from the University of This solution was then sterilized Texas M. D. Anderson Hospital and Service Organized in '59 at about 125 degrees centigrade Tumor Institute. This fact prompted David L. for 30 minutes, after which the Rogerson, who heads the Large Previous Dyer Lecturers have tank was cooled to 37 deg,·ees C., been Dr. George W. Beadle, Sir F. Scale Unit of the Section on Vita­ the optimum growth temperature MacFarlane Burnet, Dr. Rene J. min Metabolism, to record the for this particular bacterium, and event pictorially and stop for a Dubos, Dr. John Franklin Enders, additional ingredients that had Dr. Louis Pillemer, Dr. Karl F. bit of reminiscing. The service was been autoclaved separately were organized in 1959 by Dr. John C. Meyer, Dr. Richard E. Shope, Dr. added aseptically to complete the Walsh McDermott, Dr. Albert H. Or. Nirenberg Dr. Rall Keresztesy, former chief of the medium. Laboratory of Nutrition and E n­ Coons, Dr. George MacDonald, Dr. docrinology. Medium Inoculated Rollin D. Hotchkiss, Dr. Salvador The medium was then inoculated E. Luria, Dr. Harry Rubin, Dr. Batch number one, Mr. Roger­ with a pure culture of E. coli (two Alexander D. Langmuir, Dr. Karl son said, was made for Drs. Her­ liters) that had been supplied by Habel, and Dr. Robert A. Good. bert Tabor and Celia Tabor of Dr. Wickner. While the microor­ NIAMD's Laboratory of Biochem­ ganisms multiplied that night, au­ were spun out in the centrifuge ical Pharmacology on February 9, tomatic devices on the fermentor 1959. rotor, the liquid in which they controlled foaming and assured grew was collected, disinfected, and Significantly, the organism pro­ that the culture would be main­ duced then was E. coli, the same discarded. The bacteria were then tained at the proper growth tem­ removed from the rotor, weighed, species of bacteria as batch 1,000- perature. Mr. Brubach Mr. Smith ordered by Dr. Reed Wickner of and frozen. the same laboratory. Since the pa1ticular bacterium Since Dr. Widmer needed a par­ its inception in 1948 when it was being grown is aerobic, that is, it ( icula1· enzyme found inside the E. known as the Experimental Biol­ Many Strains Grown re<1ui res air to thrive, sterilized coli cell, the frozen cells were ogy and Medicine Institute. Dr. Wickner is using the bac­ air was injected into the tank thawed, suspended in buffer solu- teria to purify an enzyme needed through another device called the Mr. Smith was appointed to the 1i on in large Waring blenders, and for his studies of enzyme stn1c­ Sparger at the rate of eight cubic t he n passed th1·ough a Gaulin lab­ DRG staff in 1963. He joined DRG ture and spennidine biosynthesis. feet pe r minute. after serving as deputy assistant oratory homogenizer to crack the administrator fo1· management of Many rufferent strains of non­ Final Steps Described cell walls and release the enzyme. the Foreign Agriculture Service of pathogenic bacteria and mutants On the following morning, the Once again the substance was the Department of Agriculture for have prolife,·ated in the original culture's growth was checked pho­ centrifuged to remove cell debris. 11 years. 100-gallon fermentor and a similar tometrically for optimum growth The end product, five liters (about He has also held administrative one added in 1962. A third tank is and then the culture was cooled to five quarts) of a solution contain­ posts with the Departments of now being installed which has a prevent lysis (to keep the cell walls i'1g the desired enzyme, was re­ State and Commerce, the War As­ capacity of 300 gall ons. from breaking down). turned to Dr. Wickner. sets Administration, and the Office Mr. Roge1·son explained that the In the next step, the bacteria of Inter-American Affairs (now the making of batch No. 1,000 began were recovered from the tank in a A major goal of tuberculosis con­ Agency for International Develop­ about one o'clock on the afternoon large Sharpless refrigerated cen­ trol is to break the infection chain ment). of March 20, when chemical nu- trifuge. After the bacterial cells from older to younger generations. Page 8 April 16, 1968 THE NIH RECORD Dr. Makio Murayama' s Hemoglobin Model COMPONENTS New Brothure Describes (C,mti·mied /r