NIK memmd DEPARTMENT OF June 16,1958, Vol. X, No. 12 PUBLIC HEALTH SERVICE HEALTH. EDUCATION, AND WELFARE NATIONAL INSTITUTES OF HEALTH DR. BURNEY ELECTED OSCAR" AWARDEDNCI COLLECTS RECORDS PRESIDENT OF W.H.O. OF CANCER PATIENTS Dr. Leroy E. Burney, Surgeon Case histories of thousands of General, PHS, was unanimously cancer patients are being compiled elected president of the World Health by NCI to provide a statistical basis Organization at its 11th annual as­ for evaluating cancer treatments and sembly in Minneapolis May 30. to learn more about rare forms of Dr. Burney, who is 51, began pre­ the disease. siding immediately after his elec­ Reports on 500,000 patients are tion. He is the chief U. S. delegate being submitted to NCI this year by to WHO. approximately 200 hospitals A commissioned officer in PHS throughout the country. The Cancer since 1932, Dr. Burney was Deputy Chemotherapy National Service Chief of the Bureau of State Services Center, NCI, is collecting the re­ before he became Surgeon General ports and will receive information on in August 1956. 50,000 new patients a year. When correlated, the data will provide NCI scientists with a basis Science Teachers Gain for comparing the results of chemo­ Dr. C. J. Van Slyke poses with his surprise Research Experience award, the "Van Oscar." (See story, page 4.) therapy with radiation and surgery in treating cancer. In NIH Laboratories Contracts totaling $223,812 have Seventeen high school science NIAMD COLLABORATES IN been awarded to 10 large medical teachers are gaining practical re­ STUDY OF RARE DISEASE institutions and five central regis­ search experience at NIH this sum­ tries. The registries are collecting mer as part of a work-study insti­ A clinical study of Reiter's dis­ data from 190 hospitals participating tute sponsored by American Uni­ ease, a rare malady often mistaken in the study. versity. for rheumatoid arthritis, has been For the third y-ar, science teach­ undertaken by NIAMD in cooperation Dr. Field Honored ers from all ove»* ti 9U. S. have been with Walter Reed Army Hospital. assigned to NIH laboratories where The study will utilize advanced For Diabetes Work they are assisting in phases of re­ tissue culture techniques in an at­ The 1958 Lilly Award will be pre­ search for an eight-week period. tempt to isolate the cause of the dis­ sented to Dr. James B. Field, Clini­ Lectures and supervised laboratory ease. If this can be done, it may of­ cal Endocrinology Branch, NIAMD, studies at American University are fer important clues about the cause at the 18th meeting of the American also part of the work-study program. of rheumatoid arthritis. Diabetes Association June 21-22 in While at NIH, the teachers have an Reiter's disease is seen most fre­ San Francisco, Calif. The annual opportunity to observe the latest re­ quently in military personnel and award, consisting of $1,000 and a search techniques and to gain ex­ may be infectious. Present evidence medal, is supported by Eli Lilly and perience that will enable them to suggests that either a bacterial or Company to recognize outstanding stimulate student interest in sci­ viral agent may cause the disease. research in the field of diabetes. ence. Intensive bacteriologic and viro- Dr. Field has devoted his energies An orientation program for the logic studies are being conducted on to diabetes research since he joined science teachers will be held here selected patients transferred to the the NIH staff in 1954. He is cur­ June 23. Talks and films will intro­ CC from Walter Reed Army Hos­ rently engaged in postdoctoral stud­ duce them to the organization and pital. ies at King's College Hospital, Lon­ functions of NIH and PHS. The cooperative study is being di­ don, and will return to NIH in August. The teachers institute is sup­ rected by Dr. Joseph Bunim, Clini­ A 1951 graduate of Harvard Medi­ ported by the National Science Foun­ cal Director, NIAMD, and Gen. cal School, Dr. Field has recently dation. It is administered at NIH by Thomas Mattingly, Chief of the De­ been concerned with the problem of the Clinical and Professional Educa­ partment of Medicine, Walter Reed insulin antagonism in diabetic aci­ tion Branch, CC. Army Hospital. dosis. Silver-Staining Zecknique Publication Preview The following manuscripts were received by No. 207 in a Series the 5RB Editorial Section between March 26 and April 10. histological study of normal and de­ generative changes was generally OD disappointing. Dublin, T. D. Looking ahead in epidemiology. Dr. Rasmussen's method, which was developed with the patient as­ DBS Eddy, B. E.; Stewart, S. E.;and Berkeley, W. sistance of research technician Edna Cytopathogenicity in tissue cultures by a tumor P. McCrane, has certain advantages virus from mice. that make it unique among staining processes. The synaptic substance DRG Hill, R. T. Paradoxical effects of ovarian in the terminal endings can be seen secretions. for the first time. The nonneuro- fibrillar components of the synapse are far more voluminous than for­ Severinghaus, J. W., and Bradley, A. F. Elec­ merly suspected. Almost the entire trodes for blood 0„ and CO„ determination. surface of the nerve cell is thickly NCI encrusted with the tiny buttons. Birnbaum, S. M.; Greenstein, M. E.; Wtnitz, M.; Though the physical chemistry of and Greenstein, J. P. Quantitative nutritional silvering of nervous tissue is still studies with water-soluble, chemically defined diets. VI. Growth studies on mice. poorly understood, it is known that Cook, J. S., and Blum, H. F. Dose relationships the site of silver deposition is and oxygen dependence in ultraviolet and photo- The black particles around this nerve cell greatly influenced by pretreatment dynamic hemolysis. Elkind, M. M., and Sutton, H. Sites of action are the silvered synaptic substance in the of the tissue with a suitable fixative of lethal irradiation overlap in sites for x-ray, terminal endings. and an effective mordant. The mor­ ultraviolet, photoreactivation and ultraviolet dant, in this stain, is the substance protection and reactivation in dividing yeast that makes the fixed tissue receptive cells. At long last, after experimenta­ to silver. Gamble, D. F. Chemical activities and publi­ tion with 40 or 50 modifications, The chief ingredient of Rasmus­ cations of the Public Health Service. Dr. Grant L. Rasmussen, Chief, Heller, J. R. Cancer and the outlook. sen's formula, and the most essen­ Landau, B. R.; Levine, H. J.; and Hertz, R. Section on Functional Neuroanat­ tial, is a solution of potassium di- Prolonged glucagon administration in a case of omy, NINDB, has achieved a satis­ chromate. The other ingredients are hyperinsul ini sm due to disseminated islet cell factory method of demonstrating solutions of chloral hydrate and sil­ carcinoma. synaptic endings in the central nerv­ ver combined with a solution of so­ Milmore, B. K. Influence of calendar years of observation and age distribution upon survival of ous system. dium thiosulfate. The high degree of patients with chronic diseases. A methodolog­ Despite many difficulties, Dr. silver selectivity achieved with the ical note. Rasmussen has arrived at a silver new stain, as depicted above, is ob­ Smith, R. R. Alteration of growth and spread impregnation method that stains the tained by the use of protargol, which of experimental and human cancer. synaptic substance surrounding the is silver combined with protein. Vilar, 0., and Hertz, R. The postnatal histo­ genesis and endocrine function of abnormal neuron without staining the cell's A section of treated tissue is de­ testes associated with urinary tract anomaly in fiberlike components and likewise veloped in a silver gelatin as if it the AXC rat. without coloring the mitochondria were a photographic negative. When Weisburger, J. H.; Wei sburger, E. K.; and known to populate the cell itself as the proper stage of development is Morris, H. P. Differences in the metabolism of N-2-fluorenylacetamide in the guinea pig and the well as its terminals. reached, the areas where the synap­ rat. Dr. Rasmussen's highly selective, ses are found are seen as dark re­ Westfall, B. B.; Evans, V. J.; Peppers, E. V.; and extremely reliable, silver- gions against a yellowish background Hawkins, N. M.; Bryant, J. C; Schilling, E. L.; staining formula avoids the density of fibers and cells. The synaptic and Earie, W. R. Observations on the metabolic endings are darkest of all. If more behavior of a clone of mouse liver cells grown .n of color that in the past has tended agitated fluid suspension. to emphasize cell body and cell fi­ background detail is desired, the tis­ bers and to complicate study of the sue is gold toned and slightly warmed NH1 synapse by obscuring the presence of overnight. For some unknown rea­ Bragdon, J. H. On the composition of chyle the synaptic terminals. son, the heat seems to change the chylomicrons. background hue to rose and the color Chen, P. S., Jr. Liquid scintillation counting Like all silver-staining tech­ of C14and H3 in plasma and serum. niques, the new one must be handled of the terminals to deep blue or Dayton, P. G.; Eisenberg, F., Jr.; and Burns, with care. purple. J. J. Studies on intermediary metabolism of Many neurological difficulties, Already applied to hearing and L-ascorbic acid in guinea pigs. Dethier, V. G., and Bodenstein, D. Hunger in ranging from malfunction of the sight research in NINDB and to the blowfly. brain to the explosive reactions that widely diversified investigations of Maling, H. M., an6 Highman, B. Exaggerated accompany strychnine poisoning, the synapse in the United States and ventricular arrhythmias an6 myocardial fatty occur when the nervous impulse fails elsewhere in the world, the use of changes after large doses of norepinephrine and to cross the synapse properly.